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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ZNF148-ZFP36 (FusionGDB2 ID:101536) |
Fusion Gene Summary for ZNF148-ZFP36 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNF148-ZFP36 | Fusion gene ID: 101536 | Hgene | Tgene | Gene symbol | ZNF148 | ZFP36 | Gene ID | 7707 | 7538 |
| Gene name | zinc finger protein 148 | ZFP36 ring finger protein | |
| Synonyms | BERF-1|BFCOL1|GDACCF|HT-BETA|ZBP-89|ZFP148|pHZ-52 | G0S24|GOS24|NUP475|RNF162A|TIS11|TTP|zfp-36 | |
| Cytomap | 3q21.2 | 19q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein 148CACCC box-binding proteinCLL-associated antigen KW-10transcription factor ZBP-89zinc finger DNA-binding protein 89 | mRNA decay activator protein ZFP36G0/G1 switch regulatory protein 24growth factor-inducible nuclear protein NUP475tristetraprolintristetraprolinezinc finger protein 36 homologzinc finger protein 36, C3H type, homologzinc finger protein, C3H type, 3 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | Q07352 | |
| Ensembl transtripts involved in fusion gene | ENST00000360647, ENST00000468369, ENST00000484491, ENST00000485866, ENST00000492394, ENST00000497929, ENST00000544464, | ENST00000248673, ENST00000597629, ENST00000594045, | |
| Fusion gene scores | * DoF score | 21 X 13 X 12=3276 | 7 X 7 X 1=49 |
| # samples | 24 | 7 | |
| ** MAII score | log2(24/3276*10)=-3.77082904603249 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/49*10)=0.514573172829758 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ZNF148 [Title/Abstract] AND ZFP36 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ZNF148(124991033)-ZFP36(39899709), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ZNF148 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 12771217 |
| Hgene | ZNF148 | GO:0010629 | negative regulation of gene expression | 12771217 |
| Hgene | ZNF148 | GO:0045892 | negative regulation of transcription, DNA-templated | 12771217 |
| Tgene | ZFP36 | GO:0000288 | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | 23644599 |
| Tgene | ZFP36 | GO:0006402 | mRNA catabolic process | 10330172|10751406|11782475|20221403 |
| Tgene | ZFP36 | GO:0009611 | response to wounding | 27182009 |
| Tgene | ZFP36 | GO:0031086 | nuclear-transcribed mRNA catabolic process, deadenylation-independent decay | 11279239 |
| Tgene | ZFP36 | GO:0032680 | regulation of tumor necrosis factor production | 15014438 |
| Tgene | ZFP36 | GO:0042594 | response to starvation | 15014438 |
| Tgene | ZFP36 | GO:0043488 | regulation of mRNA stability | 9703499|11719186|15687258|20702587 |
| Tgene | ZFP36 | GO:0044344 | cellular response to fibroblast growth factor stimulus | 20166898 |
| Tgene | ZFP36 | GO:0045647 | negative regulation of erythrocyte differentiation | 20702587 |
| Tgene | ZFP36 | GO:0060213 | positive regulation of nuclear-transcribed mRNA poly(A) tail shortening | 10330172 |
| Tgene | ZFP36 | GO:0061158 | 3'-UTR-mediated mRNA destabilization | 9703499|11719186|15687258|20221403|27193233 |
| Tgene | ZFP36 | GO:0070935 | 3'-UTR-mediated mRNA stabilization | 15014438 |
| Tgene | ZFP36 | GO:0071222 | cellular response to lipopolysaccharide | 14766228 |
| Tgene | ZFP36 | GO:0071356 | cellular response to tumor necrosis factor | 20166898 |
| Tgene | ZFP36 | GO:0071364 | cellular response to epidermal growth factor stimulus | 20166898 |
| Tgene | ZFP36 | GO:0071385 | cellular response to glucocorticoid stimulus | 20166898 |
| Tgene | ZFP36 | GO:0097011 | cellular response to granulocyte macrophage colony-stimulating factor stimulus | 20166898 |
| Tgene | ZFP36 | GO:1900153 | positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | 12748283 |
| Tgene | ZFP36 | GO:1901835 | positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA | 16364915 |
| Fusion gene breakpoints across ZNF148 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across ZFP36 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS5.0 | N/A | BF094229 | ZNF148 | chr3 | 124991033 | + | ZFP36 | chr19 | 39899709 | - |
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Fusion Gene ORF analysis for ZNF148-ZFP36 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000360647 | ENST00000248673 | ZNF148 | chr3 | 124991033 | + | ZFP36 | chr19 | 39899709 | - |
| intron-3UTR | ENST00000360647 | ENST00000597629 | ZNF148 | chr3 | 124991033 | + | ZFP36 | chr19 | 39899709 | - |
| intron-3UTR | ENST00000468369 | ENST00000248673 | ZNF148 | chr3 | 124991033 | + | ZFP36 | chr19 | 39899709 | - |
| intron-3UTR | ENST00000468369 | ENST00000597629 | ZNF148 | chr3 | 124991033 | + | ZFP36 | chr19 | 39899709 | - |
| intron-3UTR | ENST00000484491 | ENST00000248673 | ZNF148 | chr3 | 124991033 | + | ZFP36 | chr19 | 39899709 | - |
| intron-3UTR | ENST00000484491 | ENST00000597629 | ZNF148 | chr3 | 124991033 | + | ZFP36 | chr19 | 39899709 | - |
| intron-3UTR | ENST00000485866 | ENST00000248673 | ZNF148 | chr3 | 124991033 | + | ZFP36 | chr19 | 39899709 | - |
| intron-3UTR | ENST00000485866 | ENST00000597629 | ZNF148 | chr3 | 124991033 | + | ZFP36 | chr19 | 39899709 | - |
| intron-3UTR | ENST00000492394 | ENST00000248673 | ZNF148 | chr3 | 124991033 | + | ZFP36 | chr19 | 39899709 | - |
| intron-3UTR | ENST00000492394 | ENST00000597629 | ZNF148 | chr3 | 124991033 | + | ZFP36 | chr19 | 39899709 | - |
| intron-3UTR | ENST00000497929 | ENST00000248673 | ZNF148 | chr3 | 124991033 | + | ZFP36 | chr19 | 39899709 | - |
| intron-3UTR | ENST00000497929 | ENST00000597629 | ZNF148 | chr3 | 124991033 | + | ZFP36 | chr19 | 39899709 | - |
| intron-3UTR | ENST00000544464 | ENST00000248673 | ZNF148 | chr3 | 124991033 | + | ZFP36 | chr19 | 39899709 | - |
| intron-3UTR | ENST00000544464 | ENST00000597629 | ZNF148 | chr3 | 124991033 | + | ZFP36 | chr19 | 39899709 | - |
| intron-intron | ENST00000360647 | ENST00000594045 | ZNF148 | chr3 | 124991033 | + | ZFP36 | chr19 | 39899709 | - |
| intron-intron | ENST00000468369 | ENST00000594045 | ZNF148 | chr3 | 124991033 | + | ZFP36 | chr19 | 39899709 | - |
| intron-intron | ENST00000484491 | ENST00000594045 | ZNF148 | chr3 | 124991033 | + | ZFP36 | chr19 | 39899709 | - |
| intron-intron | ENST00000485866 | ENST00000594045 | ZNF148 | chr3 | 124991033 | + | ZFP36 | chr19 | 39899709 | - |
| intron-intron | ENST00000492394 | ENST00000594045 | ZNF148 | chr3 | 124991033 | + | ZFP36 | chr19 | 39899709 | - |
| intron-intron | ENST00000497929 | ENST00000594045 | ZNF148 | chr3 | 124991033 | + | ZFP36 | chr19 | 39899709 | - |
| intron-intron | ENST00000544464 | ENST00000594045 | ZNF148 | chr3 | 124991033 | + | ZFP36 | chr19 | 39899709 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for ZNF148-ZFP36 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for ZNF148-ZFP36 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:124991033/:39899709) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | ZFP36 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258). Functions by recruiting the CCR4-NOT deadenylase complex and components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:15687258, PubMed:18326031, PubMed:25106868). Induces also the degradation of ARE-containing mRNAs even in absence of poly(A) tail (By similarity). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Promotes ARE-mediated mRNA decay of mineralocorticoid receptor NR3C2 mRNA in response to hypertonic stress (PubMed:24700863). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Positively regulates monocyte/macrophage cell differentiation by promoting ARE-mediated mRNA decay of the cyclin-dependent kinase CDK6 mRNA (PubMed:26542173). Promotes degradation of ARE-containing pluripotency-associated mRNAs in embryonic stem cells (ESCs), such as NANOG, through a fibroblast growth factor (FGF)-induced MAPK-dependent signaling pathway, and hence attenuates ESC self-renewal and positively regulates mesendoderm differentiation (By similarity). May play a role in mediating pro-apoptotic effects in malignant B-cells by promoting ARE-mediated mRNA decay of BCL2 mRNA (PubMed:25014217). In association with ZFP36L2 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination and functional immune cell formation (By similarity). Together with ZFP36L2 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA (By similarity). Participates in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, plays a role in the regulation of nuclear mRNA 3'-end processing; modulates mRNA 3'-end maturation efficiency of the DLL4 mRNA through binding with an ARE embedded in a weak noncanonical polyadenylation (poly(A)) signal in endothelial cells (PubMed:21832157). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (PubMed:15967811). Plays a role in vasculogenesis and endocardial development (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role in myoblast cell differentiation (By similarity). {ECO:0000250|UniProtKB:P17431, ECO:0000250|UniProtKB:P23950, ECO:0000269|PubMed:12198173, ECO:0000269|PubMed:15467755, ECO:0000269|PubMed:15538381, ECO:0000269|PubMed:15687258, ECO:0000269|PubMed:15967811, ECO:0000269|PubMed:17030608, ECO:0000269|PubMed:17369404, ECO:0000269|PubMed:18326031, ECO:0000269|PubMed:19179481, ECO:0000269|PubMed:20702587, ECO:0000269|PubMed:21832157, ECO:0000269|PubMed:24700863, ECO:0000269|PubMed:25014217, ECO:0000269|PubMed:25106868, ECO:0000269|PubMed:26542173, ECO:0000269|PubMed:27182009}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for ZNF148-ZFP36 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for ZNF148-ZFP36 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ZNF148-ZFP36 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ZNF148-ZFP36 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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