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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF160-EXOSC5 (FusionGDB2 ID:101552)

Fusion Gene Summary for ZNF160-EXOSC5

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF160-EXOSC5
Fusion gene ID: 101552
HgeneTgene
Gene symbol

ZNF160

EXOSC5

Gene ID

90338

56915

Gene namezinc finger protein 160exosome component 5
SynonymsF11|HKr18|HZF5|KR18RRP41B|RRP46|Rrp46p|hRrp46p|p12B
Cytomap

19q13.41-q13.42

19q13.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 160KRAB zinc finger protein KR18zinc finger protein 5zinc finger protein HZF5zinc finger protein Kr18exosome complex component RRP46chronic myelogenous leukemia tumor antigen 28exosome complex exonuclease RRP46exosome component Rrp46ribosomal RNA-processing protein 46
Modification date2020031320200313
UniProtAcc.

Q9NQT4

Ensembl transtripts involved in fusion geneENST00000355147, ENST00000418871, 
ENST00000429604, ENST00000601421, 
ENST00000599056, ENST00000599729, 
ENST00000221233, ENST00000596905, 
Fusion gene scores* DoF score7 X 8 X 4=2243 X 3 X 3=27
# samples 73
** MAII scorelog2(7/224*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZNF160 [Title/Abstract] AND EXOSC5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF160(53577392)-EXOSC5(41893508), # samples:1
Anticipated loss of major functional domain due to fusion event.ZNF160-EXOSC5 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ZNF160-EXOSC5 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ZNF160-EXOSC5 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ZNF160-EXOSC5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneEXOSC5

GO:0045006

DNA deamination

21255825


check buttonFusion gene breakpoints across ZNF160 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EXOSC5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-VR-A8EOZNF160chr19

53577392

-EXOSC5chr19

41893508

-


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Fusion Gene ORF analysis for ZNF160-EXOSC5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000355147ENST00000221233ZNF160chr19

53577392

-EXOSC5chr19

41893508

-
Frame-shiftENST00000355147ENST00000596905ZNF160chr19

53577392

-EXOSC5chr19

41893508

-
Frame-shiftENST00000418871ENST00000221233ZNF160chr19

53577392

-EXOSC5chr19

41893508

-
Frame-shiftENST00000418871ENST00000596905ZNF160chr19

53577392

-EXOSC5chr19

41893508

-
Frame-shiftENST00000429604ENST00000221233ZNF160chr19

53577392

-EXOSC5chr19

41893508

-
Frame-shiftENST00000429604ENST00000596905ZNF160chr19

53577392

-EXOSC5chr19

41893508

-
Frame-shiftENST00000601421ENST00000221233ZNF160chr19

53577392

-EXOSC5chr19

41893508

-
Frame-shiftENST00000601421ENST00000596905ZNF160chr19

53577392

-EXOSC5chr19

41893508

-
In-frameENST00000599056ENST00000221233ZNF160chr19

53577392

-EXOSC5chr19

41893508

-
In-frameENST00000599056ENST00000596905ZNF160chr19

53577392

-EXOSC5chr19

41893508

-
intron-3CDSENST00000599729ENST00000221233ZNF160chr19

53577392

-EXOSC5chr19

41893508

-
intron-3CDSENST00000599729ENST00000596905ZNF160chr19

53577392

-EXOSC5chr19

41893508

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000599056ZNF160chr1953577392-ENST00000221233EXOSC5chr1941893508-1014572301660119
ENST00000599056ZNF160chr1953577392-ENST00000596905EXOSC5chr1941893508-973572301660119

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000599056ENST00000221233ZNF160chr1953577392-EXOSC5chr1941893508-0.248787210.7512128
ENST00000599056ENST00000596905ZNF160chr1953577392-EXOSC5chr1941893508-0.257734240.74226576

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Fusion Genomic Features for ZNF160-EXOSC5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF160-EXOSC5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:53577392/chr19:41893508)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.EXOSC5

Q9NQT4

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. {ECO:0000269|PubMed:11782436, ECO:0000269|PubMed:21255825}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF160chr19:53577392chr19:41893508ENST00000418871-568_7990819.0DomainKRAB
HgeneZNF160chr19:53577392chr19:41893508ENST00000429604-678_7990819.0DomainKRAB
HgeneZNF160chr19:53577392chr19:41893508ENST00000599056-678_7990819.0DomainKRAB

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF160chr19:53577392chr19:41893508ENST00000418871-56257_27990819.0Zinc fingerC2H2-type 1
HgeneZNF160chr19:53577392chr19:41893508ENST00000418871-56285_30790819.0Zinc fingerC2H2-type 2
HgeneZNF160chr19:53577392chr19:41893508ENST00000418871-56313_33590819.0Zinc fingerC2H2-type 3
HgeneZNF160chr19:53577392chr19:41893508ENST00000418871-56341_36390819.0Zinc fingerC2H2-type 4
HgeneZNF160chr19:53577392chr19:41893508ENST00000418871-56369_39190819.0Zinc fingerC2H2-type 5
HgeneZNF160chr19:53577392chr19:41893508ENST00000418871-56397_41990819.0Zinc fingerC2H2-type 6
HgeneZNF160chr19:53577392chr19:41893508ENST00000418871-56425_44790819.0Zinc fingerC2H2-type 7
HgeneZNF160chr19:53577392chr19:41893508ENST00000418871-56453_47590819.0Zinc fingerC2H2-type 8
HgeneZNF160chr19:53577392chr19:41893508ENST00000418871-56481_50390819.0Zinc fingerC2H2-type 9
HgeneZNF160chr19:53577392chr19:41893508ENST00000418871-56509_53190819.0Zinc fingerC2H2-type 10
HgeneZNF160chr19:53577392chr19:41893508ENST00000418871-56537_55990819.0Zinc fingerC2H2-type 11
HgeneZNF160chr19:53577392chr19:41893508ENST00000418871-56565_58790819.0Zinc fingerC2H2-type 12
HgeneZNF160chr19:53577392chr19:41893508ENST00000418871-56593_61590819.0Zinc fingerC2H2-type 13
HgeneZNF160chr19:53577392chr19:41893508ENST00000418871-56621_64390819.0Zinc fingerC2H2-type 14
HgeneZNF160chr19:53577392chr19:41893508ENST00000418871-56649_67190819.0Zinc fingerC2H2-type 15
HgeneZNF160chr19:53577392chr19:41893508ENST00000418871-56677_69990819.0Zinc fingerC2H2-type 16
HgeneZNF160chr19:53577392chr19:41893508ENST00000418871-56705_72790819.0Zinc fingerC2H2-type 17
HgeneZNF160chr19:53577392chr19:41893508ENST00000418871-56733_75590819.0Zinc fingerC2H2-type 18
HgeneZNF160chr19:53577392chr19:41893508ENST00000418871-56761_78390819.0Zinc fingerC2H2-type 19
HgeneZNF160chr19:53577392chr19:41893508ENST00000418871-56789_81190819.0Zinc fingerC2H2-type 20
HgeneZNF160chr19:53577392chr19:41893508ENST00000429604-67257_27990819.0Zinc fingerC2H2-type 1
HgeneZNF160chr19:53577392chr19:41893508ENST00000429604-67285_30790819.0Zinc fingerC2H2-type 2
HgeneZNF160chr19:53577392chr19:41893508ENST00000429604-67313_33590819.0Zinc fingerC2H2-type 3
HgeneZNF160chr19:53577392chr19:41893508ENST00000429604-67341_36390819.0Zinc fingerC2H2-type 4
HgeneZNF160chr19:53577392chr19:41893508ENST00000429604-67369_39190819.0Zinc fingerC2H2-type 5
HgeneZNF160chr19:53577392chr19:41893508ENST00000429604-67397_41990819.0Zinc fingerC2H2-type 6
HgeneZNF160chr19:53577392chr19:41893508ENST00000429604-67425_44790819.0Zinc fingerC2H2-type 7
HgeneZNF160chr19:53577392chr19:41893508ENST00000429604-67453_47590819.0Zinc fingerC2H2-type 8
HgeneZNF160chr19:53577392chr19:41893508ENST00000429604-67481_50390819.0Zinc fingerC2H2-type 9
HgeneZNF160chr19:53577392chr19:41893508ENST00000429604-67509_53190819.0Zinc fingerC2H2-type 10
HgeneZNF160chr19:53577392chr19:41893508ENST00000429604-67537_55990819.0Zinc fingerC2H2-type 11
HgeneZNF160chr19:53577392chr19:41893508ENST00000429604-67565_58790819.0Zinc fingerC2H2-type 12
HgeneZNF160chr19:53577392chr19:41893508ENST00000429604-67593_61590819.0Zinc fingerC2H2-type 13
HgeneZNF160chr19:53577392chr19:41893508ENST00000429604-67621_64390819.0Zinc fingerC2H2-type 14
HgeneZNF160chr19:53577392chr19:41893508ENST00000429604-67649_67190819.0Zinc fingerC2H2-type 15
HgeneZNF160chr19:53577392chr19:41893508ENST00000429604-67677_69990819.0Zinc fingerC2H2-type 16
HgeneZNF160chr19:53577392chr19:41893508ENST00000429604-67705_72790819.0Zinc fingerC2H2-type 17
HgeneZNF160chr19:53577392chr19:41893508ENST00000429604-67733_75590819.0Zinc fingerC2H2-type 18
HgeneZNF160chr19:53577392chr19:41893508ENST00000429604-67761_78390819.0Zinc fingerC2H2-type 19
HgeneZNF160chr19:53577392chr19:41893508ENST00000429604-67789_81190819.0Zinc fingerC2H2-type 20
HgeneZNF160chr19:53577392chr19:41893508ENST00000599056-67257_27990819.0Zinc fingerC2H2-type 1
HgeneZNF160chr19:53577392chr19:41893508ENST00000599056-67285_30790819.0Zinc fingerC2H2-type 2
HgeneZNF160chr19:53577392chr19:41893508ENST00000599056-67313_33590819.0Zinc fingerC2H2-type 3
HgeneZNF160chr19:53577392chr19:41893508ENST00000599056-67341_36390819.0Zinc fingerC2H2-type 4
HgeneZNF160chr19:53577392chr19:41893508ENST00000599056-67369_39190819.0Zinc fingerC2H2-type 5
HgeneZNF160chr19:53577392chr19:41893508ENST00000599056-67397_41990819.0Zinc fingerC2H2-type 6
HgeneZNF160chr19:53577392chr19:41893508ENST00000599056-67425_44790819.0Zinc fingerC2H2-type 7
HgeneZNF160chr19:53577392chr19:41893508ENST00000599056-67453_47590819.0Zinc fingerC2H2-type 8
HgeneZNF160chr19:53577392chr19:41893508ENST00000599056-67481_50390819.0Zinc fingerC2H2-type 9
HgeneZNF160chr19:53577392chr19:41893508ENST00000599056-67509_53190819.0Zinc fingerC2H2-type 10
HgeneZNF160chr19:53577392chr19:41893508ENST00000599056-67537_55990819.0Zinc fingerC2H2-type 11
HgeneZNF160chr19:53577392chr19:41893508ENST00000599056-67565_58790819.0Zinc fingerC2H2-type 12
HgeneZNF160chr19:53577392chr19:41893508ENST00000599056-67593_61590819.0Zinc fingerC2H2-type 13
HgeneZNF160chr19:53577392chr19:41893508ENST00000599056-67621_64390819.0Zinc fingerC2H2-type 14
HgeneZNF160chr19:53577392chr19:41893508ENST00000599056-67649_67190819.0Zinc fingerC2H2-type 15
HgeneZNF160chr19:53577392chr19:41893508ENST00000599056-67677_69990819.0Zinc fingerC2H2-type 16
HgeneZNF160chr19:53577392chr19:41893508ENST00000599056-67705_72790819.0Zinc fingerC2H2-type 17
HgeneZNF160chr19:53577392chr19:41893508ENST00000599056-67733_75590819.0Zinc fingerC2H2-type 18
HgeneZNF160chr19:53577392chr19:41893508ENST00000599056-67761_78390819.0Zinc fingerC2H2-type 19
HgeneZNF160chr19:53577392chr19:41893508ENST00000599056-67789_81190819.0Zinc fingerC2H2-type 20


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Fusion Gene Sequence for ZNF160-EXOSC5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>101552_101552_1_ZNF160-EXOSC5_ZNF160_chr19_53577392_ENST00000599056_EXOSC5_chr19_41893508_ENST00000221233_length(transcript)=1014nt_BP=572nt
CCTGCGCCTCGCCGTCCCCCATTCGCACACCCGATGCCCGGGGGTCGCTACGGACTTAAAATCTCCGCACCGCACCCTCCACCTCAGAAA
CGTTCCTGGATCCGAACACTGCCCCCTGACGACCTAGAGAGATCCCGGCTCCCAGCCCACTGAGTGGCTTCAGCCTCGCTGGCGCCTGCC
CCGGGCCCCGCCTACAGGGGACCCAGCTCTTCTTGCAGCCACTGGAAGCTGATCACCTGGAGTGAAGACCTCACACGAAGAAGTCTGGAA
GAAGAGGAAGAGGAAAGAAAAGGAGTCAGGGATGGCCCTTACTCAGGTACGGTTGACATTTAGGGATGTGGCCATAGAATTCTCTCAGGA
GGAGTGGAAATGCCTGGACCCTGCTCAGAGGATCTTATACAGGGACGTGATGTTGGAGAACTACTGGAACCTTGTTTCTCTGGGACTGTG
TCATTTTGATATGAATATTATCTCCATGTTGGAGGAAGGGAAAGAGCCCTGGACTGTGAAGAGCTGTGTGAAAATAGCAAGAAAACCAAG
AACGCCGGAATGTGTCAAAGGCGTGGTCACAGGAGGCCCGGGCAGTCCTGACCTTTGCCCTGGACAGCGTGGAACGGAAGCTGCTGATGT
CCAGCACCAAGGGGCTCTACTCAGACACTGAGCTCCAGCAGTGCCTGGCTGCGGCCCAGGCCGCTTCGCAACACGTCTTCCGTTTCTACC
GGGAATCGCTGCAGAGGCGTTACTCCAAGAGCTGAGGCAAGCTGGGGCAAGGGGCCGCTCCCATTGCCTCCACCCACTCACCCCCTACAG
CCTGAAGCAAACCAGCAGCCCAGCCTTGCCTCTCTGACCCATGGGCTCCTTGAGCCTGCAGCTCTGTAACCACAGGGCTCCTGTGGGGAG
GCCTTGGCCTGTGACAGCCCCCAGGCCTGGGGGCACAGATCCCCCCAGCAAGGATAACATTCAAAGGAGCTCACATTTATGGAATGGATG

>101552_101552_1_ZNF160-EXOSC5_ZNF160_chr19_53577392_ENST00000599056_EXOSC5_chr19_41893508_ENST00000221233_length(amino acids)=119AA_BP=
MALTQVRLTFRDVAIEFSQEEWKCLDPAQRILYRDVMLENYWNLVSLGLCHFDMNIISMLEEGKEPWTVKSCVKIARKPRTPECVKGVVT

--------------------------------------------------------------
>101552_101552_2_ZNF160-EXOSC5_ZNF160_chr19_53577392_ENST00000599056_EXOSC5_chr19_41893508_ENST00000596905_length(transcript)=973nt_BP=572nt
CCTGCGCCTCGCCGTCCCCCATTCGCACACCCGATGCCCGGGGGTCGCTACGGACTTAAAATCTCCGCACCGCACCCTCCACCTCAGAAA
CGTTCCTGGATCCGAACACTGCCCCCTGACGACCTAGAGAGATCCCGGCTCCCAGCCCACTGAGTGGCTTCAGCCTCGCTGGCGCCTGCC
CCGGGCCCCGCCTACAGGGGACCCAGCTCTTCTTGCAGCCACTGGAAGCTGATCACCTGGAGTGAAGACCTCACACGAAGAAGTCTGGAA
GAAGAGGAAGAGGAAAGAAAAGGAGTCAGGGATGGCCCTTACTCAGGTACGGTTGACATTTAGGGATGTGGCCATAGAATTCTCTCAGGA
GGAGTGGAAATGCCTGGACCCTGCTCAGAGGATCTTATACAGGGACGTGATGTTGGAGAACTACTGGAACCTTGTTTCTCTGGGACTGTG
TCATTTTGATATGAATATTATCTCCATGTTGGAGGAAGGGAAAGAGCCCTGGACTGTGAAGAGCTGTGTGAAAATAGCAAGAAAACCAAG
AACGCCGGAATGTGTCAAAGGCGTGGTCACAGGAGGCCCGGGCAGTCCTGACCTTTGCCCTGGACAGCGTGGAACGGAAGCTGCTGATGT
CCAGCACCAAGGGGCTCTACTCAGACACTGAGCTCCAGCAGTGCCTGGCTGCGGCCCAGGCCGCTTCGCAACACGTCTTCCGTTTCTACC
GGGAATCGCTGCAGAGGCGTTACTCCAAGAGCTGAGGCAAGCTGGGGCAAGGGGCCGCTCCCATTGCCTCCACCCACTCACCCCCTACAG
CCTGAAGCAAACCAGCAGCCCAGCCTTGCCTCTCTGACCCATGGGCTCCTTGAGCCTGCAGCTCTGTAACCACAGGGCTCCTGTGGGGAG

>101552_101552_2_ZNF160-EXOSC5_ZNF160_chr19_53577392_ENST00000599056_EXOSC5_chr19_41893508_ENST00000596905_length(amino acids)=119AA_BP=
MALTQVRLTFRDVAIEFSQEEWKCLDPAQRILYRDVMLENYWNLVSLGLCHFDMNIISMLEEGKEPWTVKSCVKIARKPRTPECVKGVVT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZNF160-EXOSC5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF160-EXOSC5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF160-EXOSC5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource