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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF180-YWHAE (FusionGDB2 ID:101574)

Fusion Gene Summary for ZNF180-YWHAE

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF180-YWHAE
Fusion gene ID: 101574
HgeneTgene
Gene symbol

ZNF180

YWHAE

Gene ID

7733

7531

Gene namezinc finger protein 180tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
SynonymsHHZ16814-3-3E|HEL2|KCIP-1|MDCR|MDS
Cytomap

19q13.31

17p13.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 18014-3-3 protein epsilon14-3-3 epsilonepididymis luminal protein 2mitochondrial import stimulation factor L subunitprotein kinase C inhibitor protein-1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptidetyrosine
Modification date2020031320200327
UniProtAcc.

P62258

Ensembl transtripts involved in fusion geneENST00000221327, ENST00000391956, 
ENST00000586637, ENST00000592529, 
ENST00000585514, ENST00000587047, 
ENST00000498643, ENST00000571732, 
ENST00000573026, ENST00000575977, 
ENST00000264335, 
Fusion gene scores* DoF score4 X 3 X 4=4825 X 13 X 12=3900
# samples 432
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(32/3900*10)=-3.60733031374961
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF180 [Title/Abstract] AND YWHAE [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF180(44983500)-YWHAE(1248793), # samples:1
Anticipated loss of major functional domain due to fusion event.ZNF180-YWHAE seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ZNF180-YWHAE seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
ZNF180-YWHAE seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneYWHAE

GO:0000165

MAPK cascade

12917326

TgeneYWHAE

GO:0034605

cellular response to heat

12917326

TgeneYWHAE

GO:0046827

positive regulation of protein export from nucleus

12917326

TgeneYWHAE

GO:0051480

regulation of cytosolic calcium ion concentration

18029012

TgeneYWHAE

GO:0060306

regulation of membrane repolarization

11953308

TgeneYWHAE

GO:1901016

regulation of potassium ion transmembrane transporter activity

11953308

TgeneYWHAE

GO:1901020

negative regulation of calcium ion transmembrane transporter activity

18029012

TgeneYWHAE

GO:1902309

negative regulation of peptidyl-serine dephosphorylation

11953308

TgeneYWHAE

GO:1905913

negative regulation of calcium ion export across plasma membrane

18029012


check buttonFusion gene breakpoints across ZNF180 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across YWHAE (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-NK-A5D1-01AZNF180chr19

44983500

-YWHAEchr17

1248793

-


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Fusion Gene ORF analysis for ZNF180-YWHAE

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000221327ENST00000498643ZNF180chr19

44983500

-YWHAEchr17

1248793

-
5CDS-intronENST00000391956ENST00000498643ZNF180chr19

44983500

-YWHAEchr17

1248793

-
5CDS-intronENST00000586637ENST00000498643ZNF180chr19

44983500

-YWHAEchr17

1248793

-
5CDS-intronENST00000592529ENST00000498643ZNF180chr19

44983500

-YWHAEchr17

1248793

-
Frame-shiftENST00000221327ENST00000571732ZNF180chr19

44983500

-YWHAEchr17

1248793

-
Frame-shiftENST00000221327ENST00000573026ZNF180chr19

44983500

-YWHAEchr17

1248793

-
Frame-shiftENST00000221327ENST00000575977ZNF180chr19

44983500

-YWHAEchr17

1248793

-
Frame-shiftENST00000391956ENST00000571732ZNF180chr19

44983500

-YWHAEchr17

1248793

-
Frame-shiftENST00000391956ENST00000573026ZNF180chr19

44983500

-YWHAEchr17

1248793

-
Frame-shiftENST00000391956ENST00000575977ZNF180chr19

44983500

-YWHAEchr17

1248793

-
Frame-shiftENST00000586637ENST00000264335ZNF180chr19

44983500

-YWHAEchr17

1248793

-
Frame-shiftENST00000586637ENST00000575977ZNF180chr19

44983500

-YWHAEchr17

1248793

-
Frame-shiftENST00000592529ENST00000264335ZNF180chr19

44983500

-YWHAEchr17

1248793

-
Frame-shiftENST00000592529ENST00000571732ZNF180chr19

44983500

-YWHAEchr17

1248793

-
Frame-shiftENST00000592529ENST00000573026ZNF180chr19

44983500

-YWHAEchr17

1248793

-
In-frameENST00000221327ENST00000264335ZNF180chr19

44983500

-YWHAEchr17

1248793

-
In-frameENST00000391956ENST00000264335ZNF180chr19

44983500

-YWHAEchr17

1248793

-
In-frameENST00000586637ENST00000571732ZNF180chr19

44983500

-YWHAEchr17

1248793

-
In-frameENST00000586637ENST00000573026ZNF180chr19

44983500

-YWHAEchr17

1248793

-
In-frameENST00000592529ENST00000575977ZNF180chr19

44983500

-YWHAEchr17

1248793

-
intron-3CDSENST00000585514ENST00000264335ZNF180chr19

44983500

-YWHAEchr17

1248793

-
intron-3CDSENST00000585514ENST00000571732ZNF180chr19

44983500

-YWHAEchr17

1248793

-
intron-3CDSENST00000585514ENST00000573026ZNF180chr19

44983500

-YWHAEchr17

1248793

-
intron-3CDSENST00000585514ENST00000575977ZNF180chr19

44983500

-YWHAEchr17

1248793

-
intron-3CDSENST00000587047ENST00000264335ZNF180chr19

44983500

-YWHAEchr17

1248793

-
intron-3CDSENST00000587047ENST00000571732ZNF180chr19

44983500

-YWHAEchr17

1248793

-
intron-3CDSENST00000587047ENST00000573026ZNF180chr19

44983500

-YWHAEchr17

1248793

-
intron-3CDSENST00000587047ENST00000575977ZNF180chr19

44983500

-YWHAEchr17

1248793

-
intron-intronENST00000585514ENST00000498643ZNF180chr19

44983500

-YWHAEchr17

1248793

-
intron-intronENST00000587047ENST00000498643ZNF180chr19

44983500

-YWHAEchr17

1248793

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000391956ZNF180chr1944983500-ENST00000264335YWHAEchr171248793-1767539133591152
ENST00000221327ZNF180chr1944983500-ENST00000264335YWHAEchr171248793-1844616135668177
ENST00000592529ZNF180chr1944983500-ENST00000575977YWHAEchr171248793-717545136597153
ENST00000586637ZNF180chr1944983500-ENST00000571732YWHAEchr171248793-1626666226669147
ENST00000586637ZNF180chr1944983500-ENST00000573026YWHAEchr171248793-1311666226669147

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000391956ENST00000264335ZNF180chr1944983500-YWHAEchr171248793-0.0267261710.9732738
ENST00000221327ENST00000264335ZNF180chr1944983500-YWHAEchr171248793-0.007833220.99216676
ENST00000592529ENST00000575977ZNF180chr1944983500-YWHAEchr171248793-0.0159503330.9840497
ENST00000586637ENST00000571732ZNF180chr1944983500-YWHAEchr171248793-0.658409950.34159002
ENST00000586637ENST00000573026ZNF180chr1944983500-YWHAEchr171248793-0.631415250.36858475

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Fusion Genomic Features for ZNF180-YWHAE


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF180-YWHAE


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:44983500/chr17:1248793)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.YWHAE

P62258

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). {ECO:0000250|UniProtKB:P62261, ECO:0000269|PubMed:12917326}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF180chr19:44983500chr17:1248793ENST00000221327-4572_145111693.0DomainKRAB
HgeneZNF180chr19:44983500chr17:1248793ENST00000221327-45353_375111693.0Zinc fingerC2H2-type 1
HgeneZNF180chr19:44983500chr17:1248793ENST00000221327-45381_403111693.0Zinc fingerC2H2-type 2
HgeneZNF180chr19:44983500chr17:1248793ENST00000221327-45409_431111693.0Zinc fingerC2H2-type 3
HgeneZNF180chr19:44983500chr17:1248793ENST00000221327-45437_459111693.0Zinc fingerC2H2-type 4
HgeneZNF180chr19:44983500chr17:1248793ENST00000221327-45465_487111693.0Zinc fingerC2H2-type 5
HgeneZNF180chr19:44983500chr17:1248793ENST00000221327-45493_515111693.0Zinc fingerC2H2-type 6
HgeneZNF180chr19:44983500chr17:1248793ENST00000221327-45521_543111693.0Zinc fingerC2H2-type 7
HgeneZNF180chr19:44983500chr17:1248793ENST00000221327-45549_571111693.0Zinc fingerC2H2-type 8
HgeneZNF180chr19:44983500chr17:1248793ENST00000221327-45577_599111693.0Zinc fingerC2H2-type 9
HgeneZNF180chr19:44983500chr17:1248793ENST00000221327-45605_627111693.0Zinc fingerC2H2-type 10
HgeneZNF180chr19:44983500chr17:1248793ENST00000221327-45633_655111693.0Zinc fingerC2H2-type 11
HgeneZNF180chr19:44983500chr17:1248793ENST00000221327-45661_683111693.0Zinc fingerC2H2-type 12


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Fusion Gene Sequence for ZNF180-YWHAE


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>101574_101574_1_ZNF180-YWHAE_ZNF180_chr19_44983500_ENST00000221327_YWHAE_chr17_1248793_ENST00000264335_length(transcript)=1844nt_BP=616nt
ACAAGAGCAGCCATTGTCCCGCGCGCGGACGCTTGCTGTCGCCGAGCAGCTCGGCCCTTCAGACTTAACCCCCAGCGGCCTTGCGGATGC
TGACTAGGAGAGGGGACCGAACTAGCTTAACCCGAGTCGGCCGTGTTGCAGAATCGGGGCAGGGGGTTGCCTAACCCGAGTTCGTCCTGC
CGCAGAGCCGTGCTAGGCACTGAGGCGGTGACAGGCCCAGCCTGGGCTGCGGGCCAGCGGACGCCCAGGTTGGTAGGGGCGTGGGGCAGC
GCTTGGTGTCCGATGCGCGCATGCGCAGGGTCTACGCGGGAAGCTGGAAGCGGTGCTCAGGACCTCAGCACCCTGCTGTGCCTGGAGGAG
AGCATGGAAGAGCAGGATGAGAAGCCCCCAGAGCCCCCGAAGGCCTGTGCACAGGATTCTTTCCTTCCTCAAGAGATTATCATCAAAGTC
GAGGGAGAAGACACTGGGTCTCTGACCATCCCATCTCAGGAAGGAGTGAACTTCAAAATTGTGACTGTGGACTTCACACGGGAGGAACAG
GGTACTTGGAACCCTGCTCAGAGGACCCTGGACAGAGATGTGATCCTGGAGAACCACAGGGACCTAGTCTCTTGGGGTGAAGAGCAGAAT
AAAGAAGCGCTGCAGGACGTGGAAGACGAAAATCAGTGAGACATAAGCCAACAAGAGAAACCATCTCTGACCACCCCCTCCTCCCCATCC
CACCCTTTGGAAACTCCCCATTGTCACTGAGAACCACCAAATCTGACTTTTACATTTGGTCTCAGAATTTAGGTTCCTGCCCTGTTGGTT
TTTTTTTTTTTTTTTTAAACAGTTTTCAAAAGTTCTTAAAGGCAAGAGTGAATTTCTGTGGATTTTACTGGTCCCAGCTTTTAGGTTCTT
TAAGACACTAACAGGACTACATAGAGGCTTTTTCAGCATTACTGTGTCGTCTCCGTGCCAGATGTGGCAAGATCACCATTAGCAAATGGA
AATTACATTTGAAAGCCATTAGACTTATAGGTGATGCAAGCATCTAAGAGAGAGGTTAATCACACTATAGAGGCATAAGTGGTATCAGTT
TTCATTTTTCTAATTGTTTAAACTGTGTTTTATACCAGTGTTTGCAAGTAATTGGGTGTTAGCTTGAGATGGTTAAAGGTGGTTTGGGGA
GGGACTTCGTTGTAATGGTTTTGCTGTAAAAAATGTTTCCAACTCCGCTGAAATGTTGCTGAAAAGCATGGTGCTGGTAACAGTTCAACA
ATCCGTGGCTGCTCATTCTTGCCTACTTTACTCTCCCACTGAAGCAGGTTAGCGTTGAAGGTGGTATGGAAAAGCCTGCATGCCTGTTCA
ATTCTTTTGTTTCTTCTCCTTCCCCCTCCCCCTACCTCCTTCCCCTCACTCCTCCCCTCCTTCGCTCGCTCAACCTCTTTTGTTCAGTAT
GTGTAACTTGAAGCTAATTTGTACTACTGGATATCTGACTGGAGCCACAGATACAGAATCTGTATTGTTCTTACTGAAACACAGCATGGA
ATTAACATTAAACTTAAATAAAACAAACCTAAATTAAAAATGCCAAATATCGCGCCTCCATCCTTTATACTTCTAAAATAAAATCTCTAG
TCCAAACACACTGACAGTATTATGTTTGCCTGAATGTGAAACATTCCTCCTTTTTTCTTCCATAAATAATTTGTTTGCTTCCCAAAGATG
TATGTTTTGGAAAAAAATTGCCTGTAGTCTGGTTGTGAAGAACACTGAGTCAGTTGATGGTGTGTCTTGTCCTCCAGACCAGGCAGCAAC

>101574_101574_1_ZNF180-YWHAE_ZNF180_chr19_44983500_ENST00000221327_YWHAE_chr17_1248793_ENST00000264335_length(amino acids)=177AA_BP=160
MQNRGRGLPNPSSSCRRAVLGTEAVTGPAWAAGQRTPRLVGAWGSAWCPMRACAGSTREAGSGAQDLSTLLCLEESMEEQDEKPPEPPKA

--------------------------------------------------------------
>101574_101574_2_ZNF180-YWHAE_ZNF180_chr19_44983500_ENST00000391956_YWHAE_chr17_1248793_ENST00000264335_length(transcript)=1767nt_BP=539nt
AAGAGCAGCCATTGTCCCGCGCGCGGACGCTTGCTGTCGCCGAGCAGCTCGGCCCTTCAGACTTAACCCCCAGCGGCCTTGCGGATGCTG
ACTAGGAGAGGGGACCGAACTAGCTTAACCCGAGTCGGCCGTGTTGCAGAATCGGGGCAGGGGGTTGCCTAACCCGAGTTCGTCCTGCCG
CAGAGCCGTGCTAGGCACTGAGGCGGTGACAGGCCCAGCCTGGGCTGCGGGCCAGCGGACGCCCAGGTTGGTAGGGGCGTGGGGCAGCGC
TTGGTGTCCGATGCGCGCATGCGCAGGGTCTACGCGGGAAGCTGGAAGCGGTGCTCAGGACCTCAGCACCCTGCTGTGCCTGGAGGAGAG
CATGGAAGAGCAGGATGAGAAGCCCCCAGAGCCCCCGAAGGCCTGTGCACAGGAAGGAGTGAACTTCAAAATTGTGACTGTGGACTTCAC
ACGGGAGGAACAGGGTACTTGGAACCCTGCTCAGAGGACCCTGGACAGAGATGTGATCCTGGAGAACCACAGGGACCTAGTCTCTTGGGG
TGAAGAGCAGAATAAAGAAGCGCTGCAGGACGTGGAAGACGAAAATCAGTGAGACATAAGCCAACAAGAGAAACCATCTCTGACCACCCC
CTCCTCCCCATCCCACCCTTTGGAAACTCCCCATTGTCACTGAGAACCACCAAATCTGACTTTTACATTTGGTCTCAGAATTTAGGTTCC
TGCCCTGTTGGTTTTTTTTTTTTTTTTTTAAACAGTTTTCAAAAGTTCTTAAAGGCAAGAGTGAATTTCTGTGGATTTTACTGGTCCCAG
CTTTTAGGTTCTTTAAGACACTAACAGGACTACATAGAGGCTTTTTCAGCATTACTGTGTCGTCTCCGTGCCAGATGTGGCAAGATCACC
ATTAGCAAATGGAAATTACATTTGAAAGCCATTAGACTTATAGGTGATGCAAGCATCTAAGAGAGAGGTTAATCACACTATAGAGGCATA
AGTGGTATCAGTTTTCATTTTTCTAATTGTTTAAACTGTGTTTTATACCAGTGTTTGCAAGTAATTGGGTGTTAGCTTGAGATGGTTAAA
GGTGGTTTGGGGAGGGACTTCGTTGTAATGGTTTTGCTGTAAAAAATGTTTCCAACTCCGCTGAAATGTTGCTGAAAAGCATGGTGCTGG
TAACAGTTCAACAATCCGTGGCTGCTCATTCTTGCCTACTTTACTCTCCCACTGAAGCAGGTTAGCGTTGAAGGTGGTATGGAAAAGCCT
GCATGCCTGTTCAATTCTTTTGTTTCTTCTCCTTCCCCCTCCCCCTACCTCCTTCCCCTCACTCCTCCCCTCCTTCGCTCGCTCAACCTC
TTTTGTTCAGTATGTGTAACTTGAAGCTAATTTGTACTACTGGATATCTGACTGGAGCCACAGATACAGAATCTGTATTGTTCTTACTGA
AACACAGCATGGAATTAACATTAAACTTAAATAAAACAAACCTAAATTAAAAATGCCAAATATCGCGCCTCCATCCTTTATACTTCTAAA
ATAAAATCTCTAGTCCAAACACACTGACAGTATTATGTTTGCCTGAATGTGAAACATTCCTCCTTTTTTCTTCCATAAATAATTTGTTTG
CTTCCCAAAGATGTATGTTTTGGAAAAAAATTGCCTGTAGTCTGGTTGTGAAGAACACTGAGTCAGTTGATGGTGTGTCTTGTCCTCCAG

>101574_101574_2_ZNF180-YWHAE_ZNF180_chr19_44983500_ENST00000391956_YWHAE_chr17_1248793_ENST00000264335_length(amino acids)=152AA_BP=135
MQNRGRGLPNPSSSCRRAVLGTEAVTGPAWAAGQRTPRLVGAWGSAWCPMRACAGSTREAGSGAQDLSTLLCLEESMEEQDEKPPEPPKA

--------------------------------------------------------------
>101574_101574_3_ZNF180-YWHAE_ZNF180_chr19_44983500_ENST00000586637_YWHAE_chr17_1248793_ENST00000571732_length(transcript)=1626nt_BP=666nt
ACAAGAGCAGCCATTGTCCCGCGCGCGGACGCTTGCTGTCGCCGAGCAGCTCGGCCCTTCAGACTTAACCCCCAGCGGCCTTGCGGATGC
TGACTAGGAGAGGGGACCGAACTAGCTTAACCCGAGTCGGCCGTGTTGCAGAATCGGGGCAGGGGGTTGCCTAACCCGAGTTCGTCCTGC
CGCAGAGCCGTGCTAGGCACTGAGGCGGTGACAGGCCCAGCCTGGGCTGCGGGCCAGCGGACGCCCAGTGCAGCTCAGGACCTCAGCACC
CTGCTGTGCCTGGAGGAGAGCATGGAAGAGCAGGATGAGAAGCCCCCAGAGCCCCCGAAGGCCTGTGCACAGATGGAGTCTTGCTCTGTT
GCCTAGGCTGGAGTACAGTGGCATGATCTTGGATCACTGCAACCTCCACCTCCTGTGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGT
AGCTGGGACTACAGGATTCTTTCCTTCCTCAAGAGATTATCATCAAAGTCGAGGGAGAAGACACTGGGTCTCTGACCATCCCATCTCAGG
AAGGAGTGAACTTCAAAATTGTGACTGTGGACTTCACACGGGAGGAACAGGGTACTTGGAACCCTGCTCAGAGGACCCTGGACAGAGATG
TGATCCTGGAGAACCACAGGGACCTAGTCTCTTGGGGTGAAGAGCAGAATAAAGAAGCGCTGCAGGACGTGGAAGACGAAAATCAGTGAG
ACATAAGCCAACAAGAGAAACCATCTCTGACCACCCCCTCCTCCCCATCCCACCCTTTGGAAACTCCCCATTGTCACTGAGAACCACCAA
ATCTGACTTTTACATTTGGTCTCAGAATTTAGGTTCCTGCCCTGTTGGTTTTTTTTTTTTTTTTTTAAACAGTTTTCAAAAGTTCTTAAA
GGCAAGAGTGAATTTCTGTGGATTTTACTGGTCCCAGCTTTTAGGTTCTTTAAGACACTAACAGGACTACATAGAGGCTTTTTCAGCATT
ACTGTGTCGTCTCCGTGCCAGATGTGGCAAGATCACCATTAGCAAATGGAAATTACATTTGAAAGCCATTAGACTTATAGGTGATGCAAG
CATCTAAGAGAGAGGTTAATCACACTATAGAGGCATAAGTGGTATCAGTTTTCATTTTTCTAATTGTTTAAACTGTGTTTTATACCAGTG
TTTGCAAGTAATTGGGTGTTAGCTTGAGATGGTTAAAGGTGGTTTGGGGAGGGACTTCGTTGTAATGGTTTTGCTGTAAAAAATGTTTCC
AACTCCGCTGAAATGTTGCTGAAAAGCATGGTGCTGGTAACAGTTCAACAATCCGTGGCTGCTCATTCTTGCCTACTTTACTCTCCCACT
GAAGCAGGTTAGCGTTGAAGGTGGTATGGAAAAGCCTGCATGCCTGTTCAATTCTTTTGTTTCTTCTCCTTCCCCCTCCCCCTACCTCCT
TCCCCTCACTCCTCCCCTCCTTCGCTCGCTCAACCTCTTTTGTTCAGTATGTGTAACTTGAAGCTAATTTGTACTACTGGATATCTGACT
GGAGCCACAGATACAGAATCTGTATTGTTCTTACTGAAACACAGCATGGAATTAACATTAAACTTAAATAAAACAAACCTAAATTAAAAA

>101574_101574_3_ZNF180-YWHAE_ZNF180_chr19_44983500_ENST00000586637_YWHAE_chr17_1248793_ENST00000571732_length(amino acids)=147AA_BP=
MRASGRPVQLRTSAPCCAWRRAWKSRMRSPQSPRRPVHRWSLALLPRLEYSGMILDHCNLHLLCSSDSPASASQVAGTTGFFPSSRDYHQ

--------------------------------------------------------------
>101574_101574_4_ZNF180-YWHAE_ZNF180_chr19_44983500_ENST00000586637_YWHAE_chr17_1248793_ENST00000573026_length(transcript)=1311nt_BP=666nt
ACAAGAGCAGCCATTGTCCCGCGCGCGGACGCTTGCTGTCGCCGAGCAGCTCGGCCCTTCAGACTTAACCCCCAGCGGCCTTGCGGATGC
TGACTAGGAGAGGGGACCGAACTAGCTTAACCCGAGTCGGCCGTGTTGCAGAATCGGGGCAGGGGGTTGCCTAACCCGAGTTCGTCCTGC
CGCAGAGCCGTGCTAGGCACTGAGGCGGTGACAGGCCCAGCCTGGGCTGCGGGCCAGCGGACGCCCAGTGCAGCTCAGGACCTCAGCACC
CTGCTGTGCCTGGAGGAGAGCATGGAAGAGCAGGATGAGAAGCCCCCAGAGCCCCCGAAGGCCTGTGCACAGATGGAGTCTTGCTCTGTT
GCCTAGGCTGGAGTACAGTGGCATGATCTTGGATCACTGCAACCTCCACCTCCTGTGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGT
AGCTGGGACTACAGGATTCTTTCCTTCCTCAAGAGATTATCATCAAAGTCGAGGGAGAAGACACTGGGTCTCTGACCATCCCATCTCAGG
AAGGAGTGAACTTCAAAATTGTGACTGTGGACTTCACACGGGAGGAACAGGGTACTTGGAACCCTGCTCAGAGGACCCTGGACAGAGATG
TGATCCTGGAGAACCACAGGGACCTAGTCTCTTGGGGTGAAGAGCAGAATAAAGAAGCGCTGCAGGACGTGGAAGACGAAAATCAGTGAG
ACATAAGCCAACAAGAGAAACCATCTCTGACCACCCCCTCCTCCCCATCCCACCCTTTGGAAACTCCCCATTGTCACTGAGAACCACCAA
ATCTGACTTTTACATTTGGTCTCAGAATTTAGGTTCCTGCCCTGTTGGTTTTTTTTTTTTTTTTTTAAACAGTTTTCAAAAGTTCTTAAA
GGCAAGAGTGAATTTCTGTGGATTTTACTGGTCCCAGCTTTTAGGTTCTTTAAGACACTAACAGGACTACATAGAGGCTTTTTCAGCATT
ACTGTGTCGTCTCCGTGCCAGATGTGGCAAGATCACCATTAGCAAATGGAAATTACATTTGAAAGCCATTAGACTTATAGGTGATGCAAG
CATCTAAGAGAGAGGTTAATCACACTATAGAGGCATAAGTGGTATCAGTTTTCATTTTTCTAATTGTTTAAACTGTGTTTTATACCAGTG
TTTGCAAGTAATTGGGTGTTAGCTTGAGATGGTTAAAGGTGGTTTGGGGAGGGACTTCGTTGTAATGGTTTTGCTGTAAAAAATGTTTCC

>101574_101574_4_ZNF180-YWHAE_ZNF180_chr19_44983500_ENST00000586637_YWHAE_chr17_1248793_ENST00000573026_length(amino acids)=147AA_BP=
MRASGRPVQLRTSAPCCAWRRAWKSRMRSPQSPRRPVHRWSLALLPRLEYSGMILDHCNLHLLCSSDSPASASQVAGTTGFFPSSRDYHQ

--------------------------------------------------------------
>101574_101574_5_ZNF180-YWHAE_ZNF180_chr19_44983500_ENST00000592529_YWHAE_chr17_1248793_ENST00000575977_length(transcript)=717nt_BP=545nt
CACAAGAGCAGCCATTGTCCCGCGCGCGGACGCTTGCTGTCGCCGAGCAGCTCGGCCCTTCAGACTTAACCCCCAGCGGCCTTGCGGATG
CTGACTAGGAGAGGGGACCGAACTAGCTTAACCCGAGTCGGCCGTGTTGCAGAATCGGGGCAGGGGGTTGCCTAACCCGAGTTCGTCCTG
CCGCAGAGCCGTGCTAGGCACTGAGGCGGTGACAGGCCCAGCCTGGGCTGCGGGCCAGCGGACGCCCAGTGCAGCTCAGGACCTCAGCAC
CCTGCTGTGCCTGGAGGAGAGCATGGAAGAGCAGGATGAGAAGCCCCCAGAGCCCCCGAAGGCCTGTGCACAGGATTCTTTCCTTCCTCA
AGAGATTATCATCAAAGTCGAGGGAGAAGACACTGGGTCTCTGACCATCCCATCTCAGGAAGGAGTGAACTTCAAAATTGTGACTGTGGA
CTTCACACGGGAGGAACAGGGTACTTGGAACCCTGCTCAGAGGACCCTGGACAGAGATGTGATCCTGGAGAACCACAGGGACCTAGTCTC
TTGGGGTGAAGAGCAGAATAAAGAAGCGCTGCAGGACGTGGAAGACGAAAATCAGTGAGACATAAGCCAACAAGAGAAACCATCTCTGAC

>101574_101574_5_ZNF180-YWHAE_ZNF180_chr19_44983500_ENST00000592529_YWHAE_chr17_1248793_ENST00000575977_length(amino acids)=153AA_BP=136
MQNRGRGLPNPSSSCRRAVLGTEAVTGPAWAAGQRTPSAAQDLSTLLCLEESMEEQDEKPPEPPKACAQDSFLPQEIIIKVEGEDTGSLT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZNF180-YWHAE


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF180-YWHAE


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF180-YWHAE


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource