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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF200-COLEC12 (FusionGDB2 ID:101600)

Fusion Gene Summary for ZNF200-COLEC12

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF200-COLEC12
Fusion gene ID: 101600
HgeneTgene
Gene symbol

ZNF200

COLEC12

Gene ID

7752

81035

Gene namezinc finger protein 200collectin subfamily member 12
Synonyms-CLP1|NSR2|SCARA4|SRCL
Cytomap

16p13.3

18p11.32

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 200collectin-12collectin placenta protein 1collectin sub-family member 12hCL-P1nurse cell scavenger receptor 2scavenger receptor class A, member 4scavenger receptor with C-type lectin
Modification date2020031320200313
UniProtAcc.

Q5KU26

Ensembl transtripts involved in fusion geneENST00000396870, ENST00000414144, 
ENST00000431561, ENST00000575948, 
ENST00000396868, ENST00000396871, 
ENST00000400256, 
Fusion gene scores* DoF score1 X 1 X 1=16 X 8 X 2=96
# samples 18
** MAII scorelog2(1/1*10)=3.32192809488736log2(8/96*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF200 [Title/Abstract] AND COLEC12 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF200(3282421)-COLEC12(480757), # samples:2
Anticipated loss of major functional domain due to fusion event.ZNF200-COLEC12 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ZNF200-COLEC12 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCOLEC12

GO:0006910

phagocytosis, recognition

11564734

TgeneCOLEC12

GO:0042742

defense response to bacterium

11564734


check buttonFusion gene breakpoints across ZNF200 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across COLEC12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-60-2712-01AZNF200chr16

3282421

-COLEC12chr18

480757

-


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Fusion Gene ORF analysis for ZNF200-COLEC12

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000396870ENST00000400256ZNF200chr16

3282421

-COLEC12chr18

480757

-
Frame-shiftENST00000414144ENST00000400256ZNF200chr16

3282421

-COLEC12chr18

480757

-
Frame-shiftENST00000431561ENST00000400256ZNF200chr16

3282421

-COLEC12chr18

480757

-
Frame-shiftENST00000575948ENST00000400256ZNF200chr16

3282421

-COLEC12chr18

480757

-
In-frameENST00000396868ENST00000400256ZNF200chr16

3282421

-COLEC12chr18

480757

-
In-frameENST00000396871ENST00000400256ZNF200chr16

3282421

-COLEC12chr18

480757

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000396868ZNF200chr163282421-ENST00000400256COLEC12chr18480757-36997932883014908
ENST00000396871ZNF200chr163282421-ENST00000400256COLEC12chr18480757-37998933853114909

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000396868ENST00000400256ZNF200chr163282421-COLEC12chr18480757-0.0018459920.998154
ENST00000396871ENST00000400256ZNF200chr163282421-COLEC12chr18480757-0.00237570.99762434

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Fusion Genomic Features for ZNF200-COLEC12


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF200-COLEC12


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:3282421/chr18:480757)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.COLEC12

Q5KU26

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid-beta in Alzheimer disease. {ECO:0000269|PubMed:11162630, ECO:0000269|PubMed:11564734, ECO:0000269|PubMed:12761161, ECO:0000269|PubMed:15845541, ECO:0000269|PubMed:16868960}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCOLEC12chr16:3282421chr18:480757ENST00000400256010215_3282743.0Coiled coilOntology_term=ECO:0000255
TgeneCOLEC12chr16:3282421chr18:480757ENST0000040025601073_1412743.0Coiled coilOntology_term=ECO:0000255
TgeneCOLEC12chr16:3282421chr18:480757ENST00000400256010443_4722743.0DomainNote=Collagen-like 1
TgeneCOLEC12chr16:3282421chr18:480757ENST00000400256010473_5292743.0DomainNote=Collagen-like 2
TgeneCOLEC12chr16:3282421chr18:480757ENST00000400256010530_5892743.0DomainNote=Collagen-like 3
TgeneCOLEC12chr16:3282421chr18:480757ENST00000400256010614_7312743.0DomainC-type lectin
TgeneCOLEC12chr16:3282421chr18:480757ENST000004002560101_372743.0Topological domainCytoplasmic
TgeneCOLEC12chr16:3282421chr18:480757ENST0000040025601059_7422743.0Topological domainExtracellular
TgeneCOLEC12chr16:3282421chr18:480757ENST0000040025601038_582743.0TransmembraneHelical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF200chr16:3282421chr18:480757ENST00000396868-45252_274154395.0Zinc fingerC2H2-type 1
HgeneZNF200chr16:3282421chr18:480757ENST00000396868-45280_302154395.0Zinc fingerC2H2-type 2
HgeneZNF200chr16:3282421chr18:480757ENST00000396868-45308_330154395.0Zinc fingerC2H2-type 3
HgeneZNF200chr16:3282421chr18:480757ENST00000396868-45336_358154395.0Zinc fingerC2H2-type 4
HgeneZNF200chr16:3282421chr18:480757ENST00000396868-45364_386154395.0Zinc fingerC2H2-type 5
HgeneZNF200chr16:3282421chr18:480757ENST00000396870-45252_274155395.0Zinc fingerC2H2-type 1
HgeneZNF200chr16:3282421chr18:480757ENST00000396870-45280_302155395.0Zinc fingerC2H2-type 2
HgeneZNF200chr16:3282421chr18:480757ENST00000396870-45308_330155395.0Zinc fingerC2H2-type 3
HgeneZNF200chr16:3282421chr18:480757ENST00000396870-45336_358155395.0Zinc fingerC2H2-type 4
HgeneZNF200chr16:3282421chr18:480757ENST00000396870-45364_386155395.0Zinc fingerC2H2-type 5
HgeneZNF200chr16:3282421chr18:480757ENST00000396871-45252_274155395.0Zinc fingerC2H2-type 1
HgeneZNF200chr16:3282421chr18:480757ENST00000396871-45280_302155395.0Zinc fingerC2H2-type 2
HgeneZNF200chr16:3282421chr18:480757ENST00000396871-45308_330155395.0Zinc fingerC2H2-type 3
HgeneZNF200chr16:3282421chr18:480757ENST00000396871-45336_358155395.0Zinc fingerC2H2-type 4
HgeneZNF200chr16:3282421chr18:480757ENST00000396871-45364_386155395.0Zinc fingerC2H2-type 5
HgeneZNF200chr16:3282421chr18:480757ENST00000414144-45252_274155396.0Zinc fingerC2H2-type 1
HgeneZNF200chr16:3282421chr18:480757ENST00000414144-45280_302155396.0Zinc fingerC2H2-type 2
HgeneZNF200chr16:3282421chr18:480757ENST00000414144-45308_330155396.0Zinc fingerC2H2-type 3
HgeneZNF200chr16:3282421chr18:480757ENST00000414144-45336_358155396.0Zinc fingerC2H2-type 4
HgeneZNF200chr16:3282421chr18:480757ENST00000414144-45364_386155396.0Zinc fingerC2H2-type 5
HgeneZNF200chr16:3282421chr18:480757ENST00000431561-45252_274155396.0Zinc fingerC2H2-type 1
HgeneZNF200chr16:3282421chr18:480757ENST00000431561-45280_302155396.0Zinc fingerC2H2-type 2
HgeneZNF200chr16:3282421chr18:480757ENST00000431561-45308_330155396.0Zinc fingerC2H2-type 3
HgeneZNF200chr16:3282421chr18:480757ENST00000431561-45336_358155396.0Zinc fingerC2H2-type 4
HgeneZNF200chr16:3282421chr18:480757ENST00000431561-45364_386155396.0Zinc fingerC2H2-type 5
HgeneZNF200chr16:3282421chr18:480757ENST00000575948-45252_274155395.0Zinc fingerC2H2-type 1
HgeneZNF200chr16:3282421chr18:480757ENST00000575948-45280_302155395.0Zinc fingerC2H2-type 2
HgeneZNF200chr16:3282421chr18:480757ENST00000575948-45308_330155395.0Zinc fingerC2H2-type 3
HgeneZNF200chr16:3282421chr18:480757ENST00000575948-45336_358155395.0Zinc fingerC2H2-type 4
HgeneZNF200chr16:3282421chr18:480757ENST00000575948-45364_386155395.0Zinc fingerC2H2-type 5


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Fusion Gene Sequence for ZNF200-COLEC12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>101600_101600_1_ZNF200-COLEC12_ZNF200_chr16_3282421_ENST00000396868_COLEC12_chr18_480757_ENST00000400256_length(transcript)=3699nt_BP=793nt
GCAGAACCACAGAGAGGCTACAGCCGTCCTGGCCTCCCTCCGGCCCTGAGAGCTCCTCTGGCCTGTCTCAAGTCTTAACGTCTCAAGCGC
AGACTGCCGGCTCCGAACGGGGAGACCAGGCTTCTGCACCGGAAACAAGGCACCGGTTGTGACGTCACAGCCGCAGAGCGCCCGACTTCC
CAGAAGGCACCGAGTCCCTGCCGTTCTCCTCAACTGGCGGCGGCGCGAACGAATAGTCGCCGGCGACCTCTTGGCTCTCTGGCAGATTTC
CTCTAGTAAGAGGTGGCTCTGGAGGCCCCGCGAAACGAGTGTGGTGTGTGGTTGCAAGGCATGATGGCTGCAAAAGTGGTTCCTATGCCC
CCAAAGCCAAAGCAGTCCTTTATACTGAGAGTTCCGCCAGACTCCAAGCTGGGCCAAGACCTACTTCGAGATGCCACTAACGGGCCCAAG
ACCATCCACCAGCTAGTGCTGGAGCACTTCCTCACCTTCTTGCCCAAGCCAAGCCTGGTCCAGCCCAGTCAGAAAGTCAAGGAGACCTTG
GTTATTATGAAAGATGTGAGCTCAAGCCTTCAGAACAGAGTGCATCCTCGTCCCTTGGTGAAGCTTCTGCCCAAAGGAGTCCAAAAGGAA
CAAGAGACAGTGTCTCTGTATTTGAAAGCTAACCCTGAGCTGGTGGTCTTTGAGGATTTGAATGTATTTCACTGCCAGGAAGAATGTGTG
AGCTTGGATCCTACTCAACAACTCACGTCAGAGAAGGAAGATGACAGCAGTGTCGGGGAAATGATGTTACTGGACGACTTCGCAGAGGAG
GAGGAGGTGCAATCCTTCGGTTACAAGCGGTTTGGTATTCAGGAAGGAACACAATGTACCAAATGTAAAAATAACTGGGCACTGAAGTTT
TCTATCATATTATTATACATTTTGTGTGCCTTGCTAACAATCACAGTAGCCATTTTGGGATATAAAGTTGTAGAGAAAATGGACAATGTC
ACAGGTGGCATGGAAACATCTCGCCAAACCTATGATGACAAGCTCACAGCAGTGGAAAGTGACCTGAAAAAATTAGGTGACCAAACTGGG
AAGAAAGCTATCAGCACCAACTCAGAACTCTCCACCTTCAGATCAGACATTCTAGATCTCCGTCAGCAACTTCGTGAGATTACAGAAAAA
ACCAGCAAGAACAAGGATACGCTGGAGAAGTTACAGGCGAGCGGGGATGCTCTGGTGGACAGGCAGAGTCAATTGAAAGAAACTTTGGAG
AATAACTCTTTCCTCATCACCACTGTAAACAAAACCCTCCAGGCGTATAATGGCTATGTCACGAATCTGCAGCAAGATACCAGCGTGCTC
CAGGGCAATCTGCAGAACCAAATGTATTCTCATAATGTGGTCATCATGAACCTCAACAACCTGAACCTGACCCAGGTGCAGCAGAGGAAC
CTCATCACGAATCTGCAGCGGTCTGTGGATGACACAAGCCAGGCTATCCAGCGAATCAAGAACGACTTTCAAAATCTGCAGCAGGTTTTT
CTTCAAGCCAAGAAGGACACGGATTGGCTGAAGGAGAAAGTGCAGAGCTTGCAGACGCTGGCTGCCAACAACTCTGCGTTGGCCAAAGCC
AACAACGACACCCTGGAGGATATGAACAGCCAGCTCAACTCATTCACAGGTCAGATGGAGAACATCACCACTATCTCTCAAGCCAACGAG
CAGAACCTGAAAGACCTGCAGGACTTACACAAAGATGCAGAGAATAGAACAGCCATCAAGTTCAACCAACTGGAGGAACGCTTCCAGCTC
TTTGAGACGGATATTGTGAACATCATTAGCAATATCAGTTACACAGCCCACCACCTGCGGACGCTGACCAGCAATCTAAATGAAGTCAGG
ACCACTTGCACAGATACCCTTACCAAACACACAGATGATCTGACCTCCTTGAATAATACCCTGGCCAACATCCGTTTGGATTCTGTTTCT
CTCAGGATGCAACAAGATTTGATGAGGTCGAGGTTAGACACTGAAGTAGCCAACTTATCAGTGATTATGGAAGAAATGAAGCTAGTAGAC
TCCAAGCATGGTCAGCTCATCAAGAATTTTACAATACTACAAGGTCCACCGGGCCCCAGGGGTCCAAGAGGTGACAGAGGATCCCAGGGA
CCCCCTGGCCCAACTGGCAACAAGGGACAGAAAGGAGAGAAGGGGGAGCCTGGACCACCTGGCCCTGCGGGTGAGAGAGGCCCAATTGGA
CCAGCTGGTCCCCCCGGAGAGCGTGGCGGCAAAGGATCTAAAGGCTCCCAGGGCCCCAAAGGCTCCCGTGGTTCCCCTGGGAAGCCCGGC
CCTCAGGGCTCCAGTGGGGACCCAGGCCCCCCGGGCCCACCAGGCAAAGAGGGACTCCCCGGCCCTCAGGGCCCTCCTGGCTTCCAGGGA
CTTCAGGGCACCGTTGGGGAGCCTGGGGTGCCTGGACCTCGGGGACTGCCAGGCTTGCCTGGGGTACCAGGCATGCCAGGCCCCAAGGGC
CCCCCCGGCCCTCCTGGCCCATCAGGAGCGGTGGTGCCCCTGGCCCTGCAGAATGAGCCAACCCCAGCACCGGAGGACAATGGCTGCCCG
CCTCACTGGAAGAACTTCACAGACAAATGCTACTATTTTTCAGTTGAGAAAGAAATTTTTGAGGATGCAAAGCTTTTCTGTGAAGACAAG
TCTTCACATCTTGTTTTCATAAACACTAGAGAGGAACAGCAATGGATAAAAAAACAGATGGTAGGGAGAGAGAGCCACTGGATCGGCCTC
ACAGACTCAGAGCGTGAAAATGAATGGAAGTGGCTGGATGGGACATCTCCAGACTACAAAAATTGGAAAGCTGGACAGCCGGATAACTGG
GGTCATGGCCATGGGCCAGGAGAAGACTGTGCTGGGTTGATTTATGCTGGGCAGTGGAACGATTTCCAATGTGAAGACGTCAATAACTTC
ATTTGCGAAAAAGACAGGGAGACAGTACTGTCATCTGCATTATAACGGACTGTGATGGGATCACATGAGCAAATTTTCAGCTCTCAAAGG
CAAAGGACACTCCTTTCTAATTGCATCACCTTCTCATCAGATTGAAAAAAAAAAAGCACTGAAAACCAATTACTGAAAAAAAATTGACAG
CTAGTGTTTTTTACCATCCGTCATTACCCAAAGACTTGGGAACTAAAATGTTCCCCAGGGTGATATGCTGATTTTCATTGTGCACATGGA
CTGAATCACATAGATTCTCCTCCGTCAGTAACCGTGCGATTATACAAATTATGTCTTCCAAAGTATGGAACACTCCAATCAGAAAAAGGT
TATCATTGGTCGTTGAGTTATGGGAAGAACTTAAGCATATACTGTGTAAACAGTGCCATACATTTCTAAAATCCCAAGTGTAGGAAAAAT
ATGCAGACATACAGATATATAGGCCAACTATTAGTAATAATATGAAATATACTTAAAGAGCTTTTAAAACTTTGTATTTTTGTACAAAAT
ATTTGTCTTTTACAATTTTTTTCCTTTTTTTTTTTTTGTCATTTTACCGACATAATACATGGAGCCAAAGAAAACAATAATGGTACTAAT
AAAAACTCCTAGGGTTTCCTGTCAGATTTAATTCTACCCAGTGGCAAAGAATTTTTTCAATTGTGGCTTTAAAAAAATAATTAAATATAC

>101600_101600_1_ZNF200-COLEC12_ZNF200_chr16_3282421_ENST00000396868_COLEC12_chr18_480757_ENST00000400256_length(amino acids)=908AA_BP=166
MEAPRNECGVWLQGMMAAKVVPMPPKPKQSFILRVPPDSKLGQDLLRDATNGPKTIHQLVLEHFLTFLPKPSLVQPSQKVKETLVIMKDV
SSSLQNRVHPRPLVKLLPKGVQKEQETVSLYLKANPELVVFEDLNVFHCQEECVSLDPTQQLTSEKEDDSSVGEMMLLDDFAEEEEVQSF
GYKRFGIQEGTQCTKCKNNWALKFSIILLYILCALLTITVAILGYKVVEKMDNVTGGMETSRQTYDDKLTAVESDLKKLGDQTGKKAIST
NSELSTFRSDILDLRQQLREITEKTSKNKDTLEKLQASGDALVDRQSQLKETLENNSFLITTVNKTLQAYNGYVTNLQQDTSVLQGNLQN
QMYSHNVVIMNLNNLNLTQVQQRNLITNLQRSVDDTSQAIQRIKNDFQNLQQVFLQAKKDTDWLKEKVQSLQTLAANNSALAKANNDTLE
DMNSQLNSFTGQMENITTISQANEQNLKDLQDLHKDAENRTAIKFNQLEERFQLFETDIVNIISNISYTAHHLRTLTSNLNEVRTTCTDT
LTKHTDDLTSLNNTLANIRLDSVSLRMQQDLMRSRLDTEVANLSVIMEEMKLVDSKHGQLIKNFTILQGPPGPRGPRGDRGSQGPPGPTG
NKGQKGEKGEPGPPGPAGERGPIGPAGPPGERGGKGSKGSQGPKGSRGSPGKPGPQGSSGDPGPPGPPGKEGLPGPQGPPGFQGLQGTVG
EPGVPGPRGLPGLPGVPGMPGPKGPPGPPGPSGAVVPLALQNEPTPAPEDNGCPPHWKNFTDKCYYFSVEKEIFEDAKLFCEDKSSHLVF
INTREEQQWIKKQMVGRESHWIGLTDSERENEWKWLDGTSPDYKNWKAGQPDNWGHGHGPGEDCAGLIYAGQWNDFQCEDVNNFICEKDR

--------------------------------------------------------------
>101600_101600_2_ZNF200-COLEC12_ZNF200_chr16_3282421_ENST00000396871_COLEC12_chr18_480757_ENST00000400256_length(transcript)=3799nt_BP=893nt
ATTTCCCAGCAGGCCCTGGGGTTAGACTGGCCGCAGCTGGAGAGGTGCCAGCCCGTCGTGGATGACTAGAGCCAACCACCTGCCTTCCGT
CTTCCAGGCAGAACCACAGAGAGGCTACAGCCGTCCTGGCCTCCCTCCGGCCCTGAGAGCTCCTCTGGCCTGTCTCAAGTCTTAACGTCT
CAAGCGCAGACTGCCGGCTCCGAACGGGGAGACCAGGCTTCTGCACCGGAAACAAGGCACCGGTTGTGACGTCACAGCCGCAGAGCGCCC
GACTTCCCAGAAGGCACCGAGTCCCTGCCGTTCTCCTCAACTGGCGGCGGCGCGAACGAATAGTCGCCGGCGACCTCTTGGCTCTCTGGC
AGATTTCCTCTAGTAAGAGGTGGCTCTGGAGGCCCCGCGAAACGAGTGTGGTGTGTGGTTGCAAGGCATGATGGCTGCAAAAGTGGTTCC
TATGCCCCCAAAGCCAAAGCAGTCCTTTATACTGAGAGTTCCGCCAGACTCCAAGCTGGGCCAAGACCTACTTCGAGATGCCACTAACGG
GCCCAAGACCATCCACCAGCTAGTGCTGGAGCACTTCCTCACCTTCTTGCCCAAGCCAAGCCTGGTCCAGCCCAGTCAGAAAGTCAAGGA
GACCTTGGTTATTATGAAAGATGTGAGCTCAAGCCTTCAGAACAGAGTGCATCCTCGTCCCTTGGTGAAGCTTCTGCCCAAAGGAGTCCA
AAAGGAACAAGAGACAGTGTCTCTGTATTTGAAAGCTAACCCTGAGGAGCTGGTGGTCTTTGAGGATTTGAATGTATTTCACTGCCAGGA
AGAATGTGTGAGCTTGGATCCTACTCAACAACTCACGTCAGAGAAGGAAGATGACAGCAGTGTCGGGGAAATGATGTTACTGGACGACTT
CGCAGAGGAGGAGGAGGTGCAATCCTTCGGTTACAAGCGGTTTGGTATTCAGGAAGGAACACAATGTACCAAATGTAAAAATAACTGGGC
ACTGAAGTTTTCTATCATATTATTATACATTTTGTGTGCCTTGCTAACAATCACAGTAGCCATTTTGGGATATAAAGTTGTAGAGAAAAT
GGACAATGTCACAGGTGGCATGGAAACATCTCGCCAAACCTATGATGACAAGCTCACAGCAGTGGAAAGTGACCTGAAAAAATTAGGTGA
CCAAACTGGGAAGAAAGCTATCAGCACCAACTCAGAACTCTCCACCTTCAGATCAGACATTCTAGATCTCCGTCAGCAACTTCGTGAGAT
TACAGAAAAAACCAGCAAGAACAAGGATACGCTGGAGAAGTTACAGGCGAGCGGGGATGCTCTGGTGGACAGGCAGAGTCAATTGAAAGA
AACTTTGGAGAATAACTCTTTCCTCATCACCACTGTAAACAAAACCCTCCAGGCGTATAATGGCTATGTCACGAATCTGCAGCAAGATAC
CAGCGTGCTCCAGGGCAATCTGCAGAACCAAATGTATTCTCATAATGTGGTCATCATGAACCTCAACAACCTGAACCTGACCCAGGTGCA
GCAGAGGAACCTCATCACGAATCTGCAGCGGTCTGTGGATGACACAAGCCAGGCTATCCAGCGAATCAAGAACGACTTTCAAAATCTGCA
GCAGGTTTTTCTTCAAGCCAAGAAGGACACGGATTGGCTGAAGGAGAAAGTGCAGAGCTTGCAGACGCTGGCTGCCAACAACTCTGCGTT
GGCCAAAGCCAACAACGACACCCTGGAGGATATGAACAGCCAGCTCAACTCATTCACAGGTCAGATGGAGAACATCACCACTATCTCTCA
AGCCAACGAGCAGAACCTGAAAGACCTGCAGGACTTACACAAAGATGCAGAGAATAGAACAGCCATCAAGTTCAACCAACTGGAGGAACG
CTTCCAGCTCTTTGAGACGGATATTGTGAACATCATTAGCAATATCAGTTACACAGCCCACCACCTGCGGACGCTGACCAGCAATCTAAA
TGAAGTCAGGACCACTTGCACAGATACCCTTACCAAACACACAGATGATCTGACCTCCTTGAATAATACCCTGGCCAACATCCGTTTGGA
TTCTGTTTCTCTCAGGATGCAACAAGATTTGATGAGGTCGAGGTTAGACACTGAAGTAGCCAACTTATCAGTGATTATGGAAGAAATGAA
GCTAGTAGACTCCAAGCATGGTCAGCTCATCAAGAATTTTACAATACTACAAGGTCCACCGGGCCCCAGGGGTCCAAGAGGTGACAGAGG
ATCCCAGGGACCCCCTGGCCCAACTGGCAACAAGGGACAGAAAGGAGAGAAGGGGGAGCCTGGACCACCTGGCCCTGCGGGTGAGAGAGG
CCCAATTGGACCAGCTGGTCCCCCCGGAGAGCGTGGCGGCAAAGGATCTAAAGGCTCCCAGGGCCCCAAAGGCTCCCGTGGTTCCCCTGG
GAAGCCCGGCCCTCAGGGCTCCAGTGGGGACCCAGGCCCCCCGGGCCCACCAGGCAAAGAGGGACTCCCCGGCCCTCAGGGCCCTCCTGG
CTTCCAGGGACTTCAGGGCACCGTTGGGGAGCCTGGGGTGCCTGGACCTCGGGGACTGCCAGGCTTGCCTGGGGTACCAGGCATGCCAGG
CCCCAAGGGCCCCCCCGGCCCTCCTGGCCCATCAGGAGCGGTGGTGCCCCTGGCCCTGCAGAATGAGCCAACCCCAGCACCGGAGGACAA
TGGCTGCCCGCCTCACTGGAAGAACTTCACAGACAAATGCTACTATTTTTCAGTTGAGAAAGAAATTTTTGAGGATGCAAAGCTTTTCTG
TGAAGACAAGTCTTCACATCTTGTTTTCATAAACACTAGAGAGGAACAGCAATGGATAAAAAAACAGATGGTAGGGAGAGAGAGCCACTG
GATCGGCCTCACAGACTCAGAGCGTGAAAATGAATGGAAGTGGCTGGATGGGACATCTCCAGACTACAAAAATTGGAAAGCTGGACAGCC
GGATAACTGGGGTCATGGCCATGGGCCAGGAGAAGACTGTGCTGGGTTGATTTATGCTGGGCAGTGGAACGATTTCCAATGTGAAGACGT
CAATAACTTCATTTGCGAAAAAGACAGGGAGACAGTACTGTCATCTGCATTATAACGGACTGTGATGGGATCACATGAGCAAATTTTCAG
CTCTCAAAGGCAAAGGACACTCCTTTCTAATTGCATCACCTTCTCATCAGATTGAAAAAAAAAAAGCACTGAAAACCAATTACTGAAAAA
AAATTGACAGCTAGTGTTTTTTACCATCCGTCATTACCCAAAGACTTGGGAACTAAAATGTTCCCCAGGGTGATATGCTGATTTTCATTG
TGCACATGGACTGAATCACATAGATTCTCCTCCGTCAGTAACCGTGCGATTATACAAATTATGTCTTCCAAAGTATGGAACACTCCAATC
AGAAAAAGGTTATCATTGGTCGTTGAGTTATGGGAAGAACTTAAGCATATACTGTGTAAACAGTGCCATACATTTCTAAAATCCCAAGTG
TAGGAAAAATATGCAGACATACAGATATATAGGCCAACTATTAGTAATAATATGAAATATACTTAAAGAGCTTTTAAAACTTTGTATTTT
TGTACAAAATATTTGTCTTTTACAATTTTTTTCCTTTTTTTTTTTTTGTCATTTTACCGACATAATACATGGAGCCAAAGAAAACAATAA
TGGTACTAATAAAAACTCCTAGGGTTTCCTGTCAGATTTAATTCTACCCAGTGGCAAAGAATTTTTTCAATTGTGGCTTTAAAAAAATAA

>101600_101600_2_ZNF200-COLEC12_ZNF200_chr16_3282421_ENST00000396871_COLEC12_chr18_480757_ENST00000400256_length(amino acids)=909AA_BP=167
MEAPRNECGVWLQGMMAAKVVPMPPKPKQSFILRVPPDSKLGQDLLRDATNGPKTIHQLVLEHFLTFLPKPSLVQPSQKVKETLVIMKDV
SSSLQNRVHPRPLVKLLPKGVQKEQETVSLYLKANPEELVVFEDLNVFHCQEECVSLDPTQQLTSEKEDDSSVGEMMLLDDFAEEEEVQS
FGYKRFGIQEGTQCTKCKNNWALKFSIILLYILCALLTITVAILGYKVVEKMDNVTGGMETSRQTYDDKLTAVESDLKKLGDQTGKKAIS
TNSELSTFRSDILDLRQQLREITEKTSKNKDTLEKLQASGDALVDRQSQLKETLENNSFLITTVNKTLQAYNGYVTNLQQDTSVLQGNLQ
NQMYSHNVVIMNLNNLNLTQVQQRNLITNLQRSVDDTSQAIQRIKNDFQNLQQVFLQAKKDTDWLKEKVQSLQTLAANNSALAKANNDTL
EDMNSQLNSFTGQMENITTISQANEQNLKDLQDLHKDAENRTAIKFNQLEERFQLFETDIVNIISNISYTAHHLRTLTSNLNEVRTTCTD
TLTKHTDDLTSLNNTLANIRLDSVSLRMQQDLMRSRLDTEVANLSVIMEEMKLVDSKHGQLIKNFTILQGPPGPRGPRGDRGSQGPPGPT
GNKGQKGEKGEPGPPGPAGERGPIGPAGPPGERGGKGSKGSQGPKGSRGSPGKPGPQGSSGDPGPPGPPGKEGLPGPQGPPGFQGLQGTV
GEPGVPGPRGLPGLPGVPGMPGPKGPPGPPGPSGAVVPLALQNEPTPAPEDNGCPPHWKNFTDKCYYFSVEKEIFEDAKLFCEDKSSHLV
FINTREEQQWIKKQMVGRESHWIGLTDSERENEWKWLDGTSPDYKNWKAGQPDNWGHGHGPGEDCAGLIYAGQWNDFQCEDVNNFICEKD

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Fusion Gene PPI Analysis for ZNF200-COLEC12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF200-COLEC12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF200-COLEC12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource