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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BRCC3-CLIC2 (FusionGDB2 ID:10161)

Fusion Gene Summary for BRCC3-CLIC2

check button Fusion gene summary
Fusion gene informationFusion gene name: BRCC3-CLIC2
Fusion gene ID: 10161
HgeneTgene
Gene symbol

BRCC3

CLIC2

Gene ID

79184

1193

Gene nameBRCA1/BRCA2-containing complex subunit 3chloride intracellular channel 2
SynonymsBRCC36|C6.1A|CXorf53CLCNL2|CLIC2b|MRXS32|XAP121
Cytomap

Xq28

Xq28

Type of geneprotein-codingprotein-coding
Descriptionlys-63-specific deubiquitinase BRCC36BRCA1-A complex subunit BRCC36BRCA1/BRCA2-containing complex subunit 36BRISC complex subunit BRCC36chloride intracellular channel protein 2
Modification date2020031320200313
UniProtAcc

P46736

O15247

Ensembl transtripts involved in fusion geneENST00000330045, ENST00000340647, 
ENST00000369459, ENST00000369462, 
ENST00000399042, 		ENST00000465553, 
ENST00000369449, 
Fusion gene scores* DoF score5 X 4 X 4=809 X 5 X 6=270
# samples 69
** MAII scorelog2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/270*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BRCC3 [Title/Abstract] AND CLIC2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBRCC3(154319114)-CLIC2(154509357), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBRCC3

GO:0010165

response to X-ray

14636569

HgeneBRCC3

GO:0070536

protein K63-linked deubiquitination

17525341|19214193

HgeneBRCC3

GO:0070537

histone H2A K63-linked deubiquitination

19202061

TgeneCLIC2

GO:0010880

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

15147738|15916532

TgeneCLIC2

GO:0051099

positive regulation of binding

15916532

TgeneCLIC2

GO:0060315

negative regulation of ryanodine-sensitive calcium-release channel activity

15147738|15916532


check buttonFusion gene breakpoints across BRCC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CLIC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-13-1487-01ABRCC3chrX

154319114

+CLIC2chrX

154509357

-


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Fusion Gene ORF analysis for BRCC3-CLIC2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000330045ENST00000465553BRCC3chrX

154319114

+CLIC2chrX

154509357

-
5CDS-5UTRENST00000340647ENST00000465553BRCC3chrX

154319114

+CLIC2chrX

154509357

-
5CDS-5UTRENST00000369459ENST00000465553BRCC3chrX

154319114

+CLIC2chrX

154509357

-
5CDS-5UTRENST00000369462ENST00000465553BRCC3chrX

154319114

+CLIC2chrX

154509357

-
5CDS-5UTRENST00000399042ENST00000465553BRCC3chrX

154319114

+CLIC2chrX

154509357

-
In-frameENST00000330045ENST00000369449BRCC3chrX

154319114

+CLIC2chrX

154509357

-
In-frameENST00000340647ENST00000369449BRCC3chrX

154319114

+CLIC2chrX

154509357

-
In-frameENST00000369459ENST00000369449BRCC3chrX

154319114

+CLIC2chrX

154509357

-
In-frameENST00000369462ENST00000369449BRCC3chrX

154319114

+CLIC2chrX

154509357

-
In-frameENST00000399042ENST00000369449BRCC3chrX

154319114

+CLIC2chrX

154509357

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000340647BRCC3chrX154319114+ENST00000369449CLIC2chrX154509357-2802659301109359
ENST00000330045BRCC3chrX154319114+ENST00000369449CLIC2chrX154509357-2788645191095358
ENST00000369459BRCC3chrX154319114+ENST00000369449CLIC2chrX154509357-2720577291027332
ENST00000369462BRCC3chrX154319114+ENST00000369449CLIC2chrX154509357-2716573251023332
ENST00000399042BRCC3chrX154319114+ENST00000369449CLIC2chrX154509357-26915480998332

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000340647ENST00000369449BRCC3chrX154319114+CLIC2chrX154509357-0.0002648020.9997352
ENST00000330045ENST00000369449BRCC3chrX154319114+CLIC2chrX154509357-0.0001822760.9998178
ENST00000369459ENST00000369449BRCC3chrX154319114+CLIC2chrX154509357-0.0001714870.99982846
ENST00000369462ENST00000369449BRCC3chrX154319114+CLIC2chrX154509357-0.0001780440.99982196
ENST00000399042ENST00000369449BRCC3chrX154319114+CLIC2chrX154509357-0.0001927420.9998073

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Fusion Genomic Features for BRCC3-CLIC2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for BRCC3-CLIC2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:154319114/chrX:154509357)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BRCC3

P46736

CLIC2

O15247

FUNCTION: Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:19214193, PubMed:20656690, PubMed:24075985, PubMed:26344097). Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs) (PubMed:20656690). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:20656690, PubMed:24075985, PubMed:26344097, PubMed:26195665). Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex (PubMed:19214193). The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). {ECO:0000269|PubMed:14636569, ECO:0000269|PubMed:16707425, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19214193, ECO:0000269|PubMed:19261746, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749, ECO:0000269|PubMed:20656690, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26344097}.FUNCTION: Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx. {ECO:0000269|PubMed:15147738, ECO:0000269|PubMed:15916532, ECO:0000269|PubMed:17945253}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBRCC3chrX:154319114chrX:154509357ENST00000330045+71112_179182720.3333333333334DomainMPN
HgeneBRCC3chrX:154319114chrX:154509357ENST00000340647+71112_179183248.0DomainMPN
HgeneBRCC3chrX:154319114chrX:154509357ENST00000369459+71012_179182814.0DomainMPN
HgeneBRCC3chrX:154319114chrX:154509357ENST00000369462+71212_179182885.0DomainMPN
HgeneBRCC3chrX:154319114chrX:154509357ENST00000330045+711122_135182720.3333333333334MotifJAMM motif
HgeneBRCC3chrX:154319114chrX:154509357ENST00000340647+711122_135183248.0MotifJAMM motif
HgeneBRCC3chrX:154319114chrX:154509357ENST00000369459+710122_135182814.0MotifJAMM motif
HgeneBRCC3chrX:154319114chrX:154509357ENST00000369462+712122_135182885.0MotifJAMM motif
TgeneCLIC2chrX:154319114chrX:154509357ENST000003694492699_23997248.0DomainNote=GST C-terminal
TgeneCLIC2chrX:154319114chrX:154509357ENST0000036944926107_24797248.0RegionNote=C-terminal
TgeneCLIC2chrX:154319114chrX:154509357ENST0000036944926151_17197248.0RegionNote=Foot loop
TgeneCLIC2chrX:154319114chrX:154509357ENST000003694492695_10697248.0RegionNote=Joint loop

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCLIC2chrX:154319114chrX:154509357ENST00000369449261_9497248.0RegionNote=N-terminal
TgeneCLIC2chrX:154319114chrX:154509357ENST00000369449261_9697248.0RegionRequired for insertion into the membrane
TgeneCLIC2chrX:154319114chrX:154509357ENST000003694492632_5297248.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane


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Fusion Gene Sequence for BRCC3-CLIC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>10161_10161_1_BRCC3-CLIC2_BRCC3_chrX_154319114_ENST00000330045_CLIC2_chrX_154509357_ENST00000369449_length(transcript)=2788nt_BP=645nt
GAGCGCACAGCGCTGGGCGCTGGGGAGGCTGCGCCGCAGCACCCGGTTGGTCAGGACCAAGTGGGCCCGAGGCGGACGTGAGAAGGGTCG
GGCCAAGATGGCGGTGCAGGTGGTGCAGGCGGTGCAGGCGGTTCATCTCGAGTCTGACGCTTTCCTCGTTTGTCTCAACCACGCTCTGAG
CACAGAGAAGGAGGAAGTAATGGGGCTGTGCATAGGGGAGTTGAACGATGATACAAGGAGTGACTCCAAATTTGCATATACTGGAACTGA
AATGCGCACAGTTGCTGAAAAGGTTGATGCCGTCAGAATTGTTCACATTCATTCTGTCATCATCTTACGACGTTCTGATAAGAGGAAGGA
CCGAGTAGAAATTTCTCCAGAGCAGCTGTCTGCAGCTTCAACAGAGGCAGAGAGGTTGGCTGAACTGACAGGCCGCCCCATGAGAGTTGT
GGGCTGGTATCATTCCCATCCTCATATAACTGTTTGGCCTTCACATGTTGATGTTCGCACACAAGCCATGTACCAGATGATGGATCAAGG
CTTTGTAGGACTTATTTTTTCCTGTTTCATAGAAGATAAGAACACAAAGACTGGCCGGGTACTCTACACTTGCTTCCAATCCATACAGGC
CCAAAAGAGTTCAGAGTACCCTCACCTGAGTCCCAAGTACAAGGAGTCTTTTGATGTGGGCTGTAACCTCTTTGCCAAGTTTTCTGCATA
CATTAAGAATACACAAAAGGAGGCAAATAAGAATTTTGAAAAATCTCTGCTCAAAGAATTCAAGCGTCTGGATGACTACTTAAACACCCC
ACTTCTGGATGAAATTGATCCAGACAGTGCTGAGGAACCCCCAGTTTCCAGAAGACTATTCTTGGATGGGGACCAGCTAACACTGGCTGA
TTGTAGCTTGTTACCCAAGCTGAACATTATTAAAGTTGCTGCCAAGAAATATCGTGACTTTGACATTCCAGCAGAATTCTCAGGAGTCTG
GCGTTATCTCCACAATGCCTATGCCCGTGAAGAATTTACCCACACGTGTCCTGAAGACAAAGAAATTGAAAATACTTACGCAAATGTGGC
TAAACAGAAGAGTTAGGAGAGCTCTTACAGGAGAAAAGGCTATATTTGTGATCAGATTTTACTTATTGACATATTAGAAAGGTTTTTGCA
AATAAGAATATGAAAAATACTGTTTCTTCTATCCAACTCTCTTATGAAAAGGAACTCTGTATTTTCTATTAGCCATAAATAATCTGTCCA
CTGTATTTTACAGGTCTTCATACTTTTACTTAATTTTCTTTATCTGTATGGCAAACCACTGCAATCCTGAATGACATGGAAAGCATCACA
ATCTTTTGCCCTTTGCTTGAATTCCTGGAATGCATACATATAAGCTAAACAGATGTCTGCAGTTATAAATGTCATAAGTAGAGGTACAAT
CTCACCCTGCTCCTTAGAAACATTTCCATATAAATCGCTAAAATAATTTCACATTTTTGTTAGTTTAATATATACATGAGTTTATTTCTG
ATATAAATAATAAATACAGAGAGTGAGCATATCAGAGAGGCAAATTCTTAAAGAATGATTTTTAAAATCAGCTCTAGGAAGAGCTCAAGA
TCAATTGGTCATAGAACAGCATTTGACGCCTAGAACTATGACCACCTCATGGTCAGAGATGAGAATGTAGCCTTTGTGACCAGATTATAT
TATTTTTAAATGAAGAAGCACTCATTAAATAAAACATAATTTTAAAAAACAATATAAGAAACAAAGTCAACTGAATCTTTTATTCATAGA
AATGAAAAGGAAAATAAAAACTGTGGCTGACCAAAAGGTCTTCTTGTTGTCCATAAAAGGATAAGGTAAACAGTCCTTAGATAATTACAA
AACTTTCTACAAAAGTTAAAATGTTACATTACTATACGTATTCAGATTCACTTGTTAAAGTACTCTTAAATCATTCAAATCTGGAAACAA
AAGCTGAACTTAACTCTTGCTCCCTCAAAAGAGAAACACAAGCATAAGTGCAGCTTCAAAAAAGGAAAATATTTTAGGCTTTGGTGGAAG
GGTGGAGTTTAGATAAAATTTAAATGAAGTAGCGTTTTAATAGGTTCAAAGAAAAGTAAGGCAATGAGCAAACTCAAAGTACTGTCCTTG
AAAACCATAGAGTCAAGATAAATGTATAGTGTATGGTTAGGTGGCAGAGAAATGCAATCATGTTGATAATCTTTGAGATACATCCTGTCA
TCAGTATATTTCAGAATACATGCAATGCACTAGCAAGTTACAATTGATAGAATACATTTGAAATGTTAAATGAAATAAGCCAGGCACAGA
AAGACAAACACCACATGATCTCACTCATATGTGGAATTTTAAAAAGTTGATCTCACTCATATGTGGAATTTTAAAAAGTTGATCTCACAC
AAGTAGAGGGTAGAATCGTGGTTACCAGGGGCTAGGGAGAGAAAGAAGGCAGAGGCACTGAAAGATGTTGGTCAATGGGTATAAAGTTAC
ACCTAGGAAGAATAAATTTTGGTATTCACCACAGTAGGGTGACTATAGCAAATAATAATGTAGCATGTATTTCAAGATAGCTAGAAAAGC
AGGTTTTTAAATGTCACCACAAAGAAATAACAAATGTTTATAGTGGTGGATATGGTAATTACGCCTATTTGATCATTATACTGTGTGTAC

>10161_10161_1_BRCC3-CLIC2_BRCC3_chrX_154319114_ENST00000330045_CLIC2_chrX_154509357_ENST00000369449_length(amino acids)=358AA_BP=209
MGRLRRSTRLVRTKWARGGREKGRAKMAVQVVQAVQAVHLESDAFLVCLNHALSTEKEEVMGLCIGELNDDTRSDSKFAYTGTEMRTVAE
KVDAVRIVHIHSVIILRRSDKRKDRVEISPEQLSAASTEAERLAELTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIF
SCFIEDKNTKTGRVLYTCFQSIQAQKSSEYPHLSPKYKESFDVGCNLFAKFSAYIKNTQKEANKNFEKSLLKEFKRLDDYLNTPLLDEID

--------------------------------------------------------------
>10161_10161_2_BRCC3-CLIC2_BRCC3_chrX_154319114_ENST00000340647_CLIC2_chrX_154509357_ENST00000369449_length(transcript)=2802nt_BP=659nt
AGGCCTGGGCGGAGCGCACAGCGCTGGGCGCTGGGGAGGCTGCGCCGCAGCACCCGGTTGGTCAGGACCAAGTGGGCCCGAGGCGGACGT
GAGAAGGGTCGGGCCAAGATGGCGGTGCAGGTGGTGCAGGCGGTGCAGGCGGTTCATCTCGAGTCTGACGCTTTCCTCGTTTGTCTCAAC
CACGCTCTGAGCACAGAGAAGGAGGAAGTAATGGGGCTGTGCATAGGGGAGTTGAACGATGATACAAGTAGGAGTGACTCCAAATTTGCA
TATACTGGAACTGAAATGCGCACAGTTGCTGAAAAGGTTGATGCCGTCAGAATTGTTCACATTCATTCTGTCATCATCTTACGACGTTCT
GATAAGAGGAAGGACCGAGTAGAAATTTCTCCAGAGCAGCTGTCTGCAGCTTCAACAGAGGCAGAGAGGTTGGCTGAACTGACAGGCCGC
CCCATGAGAGTTGTGGGCTGGTATCATTCCCATCCTCATATAACTGTTTGGCCTTCACATGTTGATGTTCGCACACAAGCCATGTACCAG
ATGATGGATCAAGGCTTTGTAGGACTTATTTTTTCCTGTTTCATAGAAGATAAGAACACAAAGACTGGCCGGGTACTCTACACTTGCTTC
CAATCCATACAGGCCCAAAAGAGTTCAGAGTACCCTCACCTGAGTCCCAAGTACAAGGAGTCTTTTGATGTGGGCTGTAACCTCTTTGCC
AAGTTTTCTGCATACATTAAGAATACACAAAAGGAGGCAAATAAGAATTTTGAAAAATCTCTGCTCAAAGAATTCAAGCGTCTGGATGAC
TACTTAAACACCCCACTTCTGGATGAAATTGATCCAGACAGTGCTGAGGAACCCCCAGTTTCCAGAAGACTATTCTTGGATGGGGACCAG
CTAACACTGGCTGATTGTAGCTTGTTACCCAAGCTGAACATTATTAAAGTTGCTGCCAAGAAATATCGTGACTTTGACATTCCAGCAGAA
TTCTCAGGAGTCTGGCGTTATCTCCACAATGCCTATGCCCGTGAAGAATTTACCCACACGTGTCCTGAAGACAAAGAAATTGAAAATACT
TACGCAAATGTGGCTAAACAGAAGAGTTAGGAGAGCTCTTACAGGAGAAAAGGCTATATTTGTGATCAGATTTTACTTATTGACATATTA
GAAAGGTTTTTGCAAATAAGAATATGAAAAATACTGTTTCTTCTATCCAACTCTCTTATGAAAAGGAACTCTGTATTTTCTATTAGCCAT
AAATAATCTGTCCACTGTATTTTACAGGTCTTCATACTTTTACTTAATTTTCTTTATCTGTATGGCAAACCACTGCAATCCTGAATGACA
TGGAAAGCATCACAATCTTTTGCCCTTTGCTTGAATTCCTGGAATGCATACATATAAGCTAAACAGATGTCTGCAGTTATAAATGTCATA
AGTAGAGGTACAATCTCACCCTGCTCCTTAGAAACATTTCCATATAAATCGCTAAAATAATTTCACATTTTTGTTAGTTTAATATATACA
TGAGTTTATTTCTGATATAAATAATAAATACAGAGAGTGAGCATATCAGAGAGGCAAATTCTTAAAGAATGATTTTTAAAATCAGCTCTA
GGAAGAGCTCAAGATCAATTGGTCATAGAACAGCATTTGACGCCTAGAACTATGACCACCTCATGGTCAGAGATGAGAATGTAGCCTTTG
TGACCAGATTATATTATTTTTAAATGAAGAAGCACTCATTAAATAAAACATAATTTTAAAAAACAATATAAGAAACAAAGTCAACTGAAT
CTTTTATTCATAGAAATGAAAAGGAAAATAAAAACTGTGGCTGACCAAAAGGTCTTCTTGTTGTCCATAAAAGGATAAGGTAAACAGTCC
TTAGATAATTACAAAACTTTCTACAAAAGTTAAAATGTTACATTACTATACGTATTCAGATTCACTTGTTAAAGTACTCTTAAATCATTC
AAATCTGGAAACAAAAGCTGAACTTAACTCTTGCTCCCTCAAAAGAGAAACACAAGCATAAGTGCAGCTTCAAAAAAGGAAAATATTTTA
GGCTTTGGTGGAAGGGTGGAGTTTAGATAAAATTTAAATGAAGTAGCGTTTTAATAGGTTCAAAGAAAAGTAAGGCAATGAGCAAACTCA
AAGTACTGTCCTTGAAAACCATAGAGTCAAGATAAATGTATAGTGTATGGTTAGGTGGCAGAGAAATGCAATCATGTTGATAATCTTTGA
GATACATCCTGTCATCAGTATATTTCAGAATACATGCAATGCACTAGCAAGTTACAATTGATAGAATACATTTGAAATGTTAAATGAAAT
AAGCCAGGCACAGAAAGACAAACACCACATGATCTCACTCATATGTGGAATTTTAAAAAGTTGATCTCACTCATATGTGGAATTTTAAAA
AGTTGATCTCACACAAGTAGAGGGTAGAATCGTGGTTACCAGGGGCTAGGGAGAGAAAGAAGGCAGAGGCACTGAAAGATGTTGGTCAAT
GGGTATAAAGTTACACCTAGGAAGAATAAATTTTGGTATTCACCACAGTAGGGTGACTATAGCAAATAATAATGTAGCATGTATTTCAAG
ATAGCTAGAAAAGCAGGTTTTTAAATGTCACCACAAAGAAATAACAAATGTTTATAGTGGTGGATATGGTAATTACGCCTATTTGATCAT
TATACTGTGTGTACATGCATTGAAACACCACATTGTATCCCATATATATGTACAATTATGTGCCCATTATACATTTAAAAAATAAATTTT

>10161_10161_2_BRCC3-CLIC2_BRCC3_chrX_154319114_ENST00000340647_CLIC2_chrX_154509357_ENST00000369449_length(amino acids)=359AA_BP=210
MGRLRRSTRLVRTKWARGGREKGRAKMAVQVVQAVQAVHLESDAFLVCLNHALSTEKEEVMGLCIGELNDDTSRSDSKFAYTGTEMRTVA
EKVDAVRIVHIHSVIILRRSDKRKDRVEISPEQLSAASTEAERLAELTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLI
FSCFIEDKNTKTGRVLYTCFQSIQAQKSSEYPHLSPKYKESFDVGCNLFAKFSAYIKNTQKEANKNFEKSLLKEFKRLDDYLNTPLLDEI

--------------------------------------------------------------
>10161_10161_3_BRCC3-CLIC2_BRCC3_chrX_154319114_ENST00000369459_CLIC2_chrX_154509357_ENST00000369449_length(transcript)=2720nt_BP=577nt
GAGGCGGACGTGAGAAGGGTCGGGCCAAGATGGCGGTGCAGGTGGTGCAGGCGGTGCAGGCGGTTCATCTCGAGTCTGACGCTTTCCTCG
TTTGTCTCAACCACGCTCTGAGCACAGAGAAGGAGGAAGTAATGGGGCTGTGCATAGGGGAGTTGAACGATGATACAAGGAGTGACTCCA
AATTTGCATATACTGGAACTGAAATGCGCACAGTTGCTGAAAAGGTTGATGCCGTCAGAATTGTTCACATTCATTCTGTCATCATCTTAC
GACGTTCTGATAAGAGGAAGGACCGAGTAGAAATTTCTCCAGAGCAGCTGTCTGCAGCTTCAACAGAGGCAGAGAGGTTGGCTGAACTGA
CAGGCCGCCCCATGAGAGTTGTGGGCTGGTATCATTCCCATCCTCATATAACTGTTTGGCCTTCACATGTTGATGTTCGCACACAAGCCA
TGTACCAGATGATGGATCAAGGCTTTGTAGGACTTATTTTTTCCTGTTTCATAGAAGATAAGAACACAAAGACTGGCCGGGTACTCTACA
CTTGCTTCCAATCCATACAGGCCCAAAAGAGTTCAGAGTACCCTCACCTGAGTCCCAAGTACAAGGAGTCTTTTGATGTGGGCTGTAACC
TCTTTGCCAAGTTTTCTGCATACATTAAGAATACACAAAAGGAGGCAAATAAGAATTTTGAAAAATCTCTGCTCAAAGAATTCAAGCGTC
TGGATGACTACTTAAACACCCCACTTCTGGATGAAATTGATCCAGACAGTGCTGAGGAACCCCCAGTTTCCAGAAGACTATTCTTGGATG
GGGACCAGCTAACACTGGCTGATTGTAGCTTGTTACCCAAGCTGAACATTATTAAAGTTGCTGCCAAGAAATATCGTGACTTTGACATTC
CAGCAGAATTCTCAGGAGTCTGGCGTTATCTCCACAATGCCTATGCCCGTGAAGAATTTACCCACACGTGTCCTGAAGACAAAGAAATTG
AAAATACTTACGCAAATGTGGCTAAACAGAAGAGTTAGGAGAGCTCTTACAGGAGAAAAGGCTATATTTGTGATCAGATTTTACTTATTG
ACATATTAGAAAGGTTTTTGCAAATAAGAATATGAAAAATACTGTTTCTTCTATCCAACTCTCTTATGAAAAGGAACTCTGTATTTTCTA
TTAGCCATAAATAATCTGTCCACTGTATTTTACAGGTCTTCATACTTTTACTTAATTTTCTTTATCTGTATGGCAAACCACTGCAATCCT
GAATGACATGGAAAGCATCACAATCTTTTGCCCTTTGCTTGAATTCCTGGAATGCATACATATAAGCTAAACAGATGTCTGCAGTTATAA
ATGTCATAAGTAGAGGTACAATCTCACCCTGCTCCTTAGAAACATTTCCATATAAATCGCTAAAATAATTTCACATTTTTGTTAGTTTAA
TATATACATGAGTTTATTTCTGATATAAATAATAAATACAGAGAGTGAGCATATCAGAGAGGCAAATTCTTAAAGAATGATTTTTAAAAT
CAGCTCTAGGAAGAGCTCAAGATCAATTGGTCATAGAACAGCATTTGACGCCTAGAACTATGACCACCTCATGGTCAGAGATGAGAATGT
AGCCTTTGTGACCAGATTATATTATTTTTAAATGAAGAAGCACTCATTAAATAAAACATAATTTTAAAAAACAATATAAGAAACAAAGTC
AACTGAATCTTTTATTCATAGAAATGAAAAGGAAAATAAAAACTGTGGCTGACCAAAAGGTCTTCTTGTTGTCCATAAAAGGATAAGGTA
AACAGTCCTTAGATAATTACAAAACTTTCTACAAAAGTTAAAATGTTACATTACTATACGTATTCAGATTCACTTGTTAAAGTACTCTTA
AATCATTCAAATCTGGAAACAAAAGCTGAACTTAACTCTTGCTCCCTCAAAAGAGAAACACAAGCATAAGTGCAGCTTCAAAAAAGGAAA
ATATTTTAGGCTTTGGTGGAAGGGTGGAGTTTAGATAAAATTTAAATGAAGTAGCGTTTTAATAGGTTCAAAGAAAAGTAAGGCAATGAG
CAAACTCAAAGTACTGTCCTTGAAAACCATAGAGTCAAGATAAATGTATAGTGTATGGTTAGGTGGCAGAGAAATGCAATCATGTTGATA
ATCTTTGAGATACATCCTGTCATCAGTATATTTCAGAATACATGCAATGCACTAGCAAGTTACAATTGATAGAATACATTTGAAATGTTA
AATGAAATAAGCCAGGCACAGAAAGACAAACACCACATGATCTCACTCATATGTGGAATTTTAAAAAGTTGATCTCACTCATATGTGGAA
TTTTAAAAAGTTGATCTCACACAAGTAGAGGGTAGAATCGTGGTTACCAGGGGCTAGGGAGAGAAAGAAGGCAGAGGCACTGAAAGATGT
TGGTCAATGGGTATAAAGTTACACCTAGGAAGAATAAATTTTGGTATTCACCACAGTAGGGTGACTATAGCAAATAATAATGTAGCATGT
ATTTCAAGATAGCTAGAAAAGCAGGTTTTTAAATGTCACCACAAAGAAATAACAAATGTTTATAGTGGTGGATATGGTAATTACGCCTAT
TTGATCATTATACTGTGTGTACATGCATTGAAACACCACATTGTATCCCATATATATGTACAATTATGTGCCCATTATACATTTAAAAAA

>10161_10161_3_BRCC3-CLIC2_BRCC3_chrX_154319114_ENST00000369459_CLIC2_chrX_154509357_ENST00000369449_length(amino acids)=332AA_BP=183
MAVQVVQAVQAVHLESDAFLVCLNHALSTEKEEVMGLCIGELNDDTRSDSKFAYTGTEMRTVAEKVDAVRIVHIHSVIILRRSDKRKDRV
EISPEQLSAASTEAERLAELTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIFSCFIEDKNTKTGRVLYTCFQSIQAQK
SSEYPHLSPKYKESFDVGCNLFAKFSAYIKNTQKEANKNFEKSLLKEFKRLDDYLNTPLLDEIDPDSAEEPPVSRRLFLDGDQLTLADCS

--------------------------------------------------------------
>10161_10161_4_BRCC3-CLIC2_BRCC3_chrX_154319114_ENST00000369462_CLIC2_chrX_154509357_ENST00000369449_length(transcript)=2716nt_BP=573nt
CGGACGTGAGAAGGGTCGGGCCAAGATGGCGGTGCAGGTGGTGCAGGCGGTGCAGGCGGTTCATCTCGAGTCTGACGCTTTCCTCGTTTG
TCTCAACCACGCTCTGAGCACAGAGAAGGAGGAAGTAATGGGGCTGTGCATAGGGGAGTTGAACGATGATACAAGGAGTGACTCCAAATT
TGCATATACTGGAACTGAAATGCGCACAGTTGCTGAAAAGGTTGATGCCGTCAGAATTGTTCACATTCATTCTGTCATCATCTTACGACG
TTCTGATAAGAGGAAGGACCGAGTAGAAATTTCTCCAGAGCAGCTGTCTGCAGCTTCAACAGAGGCAGAGAGGTTGGCTGAACTGACAGG
CCGCCCCATGAGAGTTGTGGGCTGGTATCATTCCCATCCTCATATAACTGTTTGGCCTTCACATGTTGATGTTCGCACACAAGCCATGTA
CCAGATGATGGATCAAGGCTTTGTAGGACTTATTTTTTCCTGTTTCATAGAAGATAAGAACACAAAGACTGGCCGGGTACTCTACACTTG
CTTCCAATCCATACAGGCCCAAAAGAGTTCAGAGTACCCTCACCTGAGTCCCAAGTACAAGGAGTCTTTTGATGTGGGCTGTAACCTCTT
TGCCAAGTTTTCTGCATACATTAAGAATACACAAAAGGAGGCAAATAAGAATTTTGAAAAATCTCTGCTCAAAGAATTCAAGCGTCTGGA
TGACTACTTAAACACCCCACTTCTGGATGAAATTGATCCAGACAGTGCTGAGGAACCCCCAGTTTCCAGAAGACTATTCTTGGATGGGGA
CCAGCTAACACTGGCTGATTGTAGCTTGTTACCCAAGCTGAACATTATTAAAGTTGCTGCCAAGAAATATCGTGACTTTGACATTCCAGC
AGAATTCTCAGGAGTCTGGCGTTATCTCCACAATGCCTATGCCCGTGAAGAATTTACCCACACGTGTCCTGAAGACAAAGAAATTGAAAA
TACTTACGCAAATGTGGCTAAACAGAAGAGTTAGGAGAGCTCTTACAGGAGAAAAGGCTATATTTGTGATCAGATTTTACTTATTGACAT
ATTAGAAAGGTTTTTGCAAATAAGAATATGAAAAATACTGTTTCTTCTATCCAACTCTCTTATGAAAAGGAACTCTGTATTTTCTATTAG
CCATAAATAATCTGTCCACTGTATTTTACAGGTCTTCATACTTTTACTTAATTTTCTTTATCTGTATGGCAAACCACTGCAATCCTGAAT
GACATGGAAAGCATCACAATCTTTTGCCCTTTGCTTGAATTCCTGGAATGCATACATATAAGCTAAACAGATGTCTGCAGTTATAAATGT
CATAAGTAGAGGTACAATCTCACCCTGCTCCTTAGAAACATTTCCATATAAATCGCTAAAATAATTTCACATTTTTGTTAGTTTAATATA
TACATGAGTTTATTTCTGATATAAATAATAAATACAGAGAGTGAGCATATCAGAGAGGCAAATTCTTAAAGAATGATTTTTAAAATCAGC
TCTAGGAAGAGCTCAAGATCAATTGGTCATAGAACAGCATTTGACGCCTAGAACTATGACCACCTCATGGTCAGAGATGAGAATGTAGCC
TTTGTGACCAGATTATATTATTTTTAAATGAAGAAGCACTCATTAAATAAAACATAATTTTAAAAAACAATATAAGAAACAAAGTCAACT
GAATCTTTTATTCATAGAAATGAAAAGGAAAATAAAAACTGTGGCTGACCAAAAGGTCTTCTTGTTGTCCATAAAAGGATAAGGTAAACA
GTCCTTAGATAATTACAAAACTTTCTACAAAAGTTAAAATGTTACATTACTATACGTATTCAGATTCACTTGTTAAAGTACTCTTAAATC
ATTCAAATCTGGAAACAAAAGCTGAACTTAACTCTTGCTCCCTCAAAAGAGAAACACAAGCATAAGTGCAGCTTCAAAAAAGGAAAATAT
TTTAGGCTTTGGTGGAAGGGTGGAGTTTAGATAAAATTTAAATGAAGTAGCGTTTTAATAGGTTCAAAGAAAAGTAAGGCAATGAGCAAA
CTCAAAGTACTGTCCTTGAAAACCATAGAGTCAAGATAAATGTATAGTGTATGGTTAGGTGGCAGAGAAATGCAATCATGTTGATAATCT
TTGAGATACATCCTGTCATCAGTATATTTCAGAATACATGCAATGCACTAGCAAGTTACAATTGATAGAATACATTTGAAATGTTAAATG
AAATAAGCCAGGCACAGAAAGACAAACACCACATGATCTCACTCATATGTGGAATTTTAAAAAGTTGATCTCACTCATATGTGGAATTTT
AAAAAGTTGATCTCACACAAGTAGAGGGTAGAATCGTGGTTACCAGGGGCTAGGGAGAGAAAGAAGGCAGAGGCACTGAAAGATGTTGGT
CAATGGGTATAAAGTTACACCTAGGAAGAATAAATTTTGGTATTCACCACAGTAGGGTGACTATAGCAAATAATAATGTAGCATGTATTT
CAAGATAGCTAGAAAAGCAGGTTTTTAAATGTCACCACAAAGAAATAACAAATGTTTATAGTGGTGGATATGGTAATTACGCCTATTTGA
TCATTATACTGTGTGTACATGCATTGAAACACCACATTGTATCCCATATATATGTACAATTATGTGCCCATTATACATTTAAAAAATAAA

>10161_10161_4_BRCC3-CLIC2_BRCC3_chrX_154319114_ENST00000369462_CLIC2_chrX_154509357_ENST00000369449_length(amino acids)=332AA_BP=183
MAVQVVQAVQAVHLESDAFLVCLNHALSTEKEEVMGLCIGELNDDTRSDSKFAYTGTEMRTVAEKVDAVRIVHIHSVIILRRSDKRKDRV
EISPEQLSAASTEAERLAELTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIFSCFIEDKNTKTGRVLYTCFQSIQAQK
SSEYPHLSPKYKESFDVGCNLFAKFSAYIKNTQKEANKNFEKSLLKEFKRLDDYLNTPLLDEIDPDSAEEPPVSRRLFLDGDQLTLADCS

--------------------------------------------------------------
>10161_10161_5_BRCC3-CLIC2_BRCC3_chrX_154319114_ENST00000399042_CLIC2_chrX_154509357_ENST00000369449_length(transcript)=2691nt_BP=548nt
ATGGCGGTGCAGGTGGTGCAGGCGGTGCAGGCGGTTCATCTCGAGTCTGACGCTTTCCTCGTTTGTCTCAACCACGCTCTGAGCACAGAG
AAGGAGGAAGTAATGGGGCTGTGCATAGGGGAGGTGAGTAGTCCCAGTAGGAGTGACTCCAAATTTGCATATACTGGAACTGAAATGCGC
ACAGTTGCTGAAAAGGTTGATGCCGTCAGAATTGTTCACATTCATTCTGTCATCATCTTACGACGTTCTGATAAGAGGAAGGACCGAGTA
GAAATTTCTCCAGAGCAGCTGTCTGCAGCTTCAACAGAGACACACAGGTTGGCTGAACTGACAGGCCGCCCCATGAGAGTTGTGGGCTGG
TATCATTCCCATCCTCATATAACTGTTTGGCCTTCACATGTTGATGTTCGCACACAAGCCATGTACCAGATGATGGATCAAGGCTTTGTA
GGACTTATTTTTTCCTGTTTCATAGAAGATAAGAACACAAAGACTGGCCGGGTACTCTACACTTGCTTCCAATCCATACAGGCCCAAAAG
AGTTCAGAGTACCCTCACCTGAGTCCCAAGTACAAGGAGTCTTTTGATGTGGGCTGTAACCTCTTTGCCAAGTTTTCTGCATACATTAAG
AATACACAAAAGGAGGCAAATAAGAATTTTGAAAAATCTCTGCTCAAAGAATTCAAGCGTCTGGATGACTACTTAAACACCCCACTTCTG
GATGAAATTGATCCAGACAGTGCTGAGGAACCCCCAGTTTCCAGAAGACTATTCTTGGATGGGGACCAGCTAACACTGGCTGATTGTAGC
TTGTTACCCAAGCTGAACATTATTAAAGTTGCTGCCAAGAAATATCGTGACTTTGACATTCCAGCAGAATTCTCAGGAGTCTGGCGTTAT
CTCCACAATGCCTATGCCCGTGAAGAATTTACCCACACGTGTCCTGAAGACAAAGAAATTGAAAATACTTACGCAAATGTGGCTAAACAG
AAGAGTTAGGAGAGCTCTTACAGGAGAAAAGGCTATATTTGTGATCAGATTTTACTTATTGACATATTAGAAAGGTTTTTGCAAATAAGA
ATATGAAAAATACTGTTTCTTCTATCCAACTCTCTTATGAAAAGGAACTCTGTATTTTCTATTAGCCATAAATAATCTGTCCACTGTATT
TTACAGGTCTTCATACTTTTACTTAATTTTCTTTATCTGTATGGCAAACCACTGCAATCCTGAATGACATGGAAAGCATCACAATCTTTT
GCCCTTTGCTTGAATTCCTGGAATGCATACATATAAGCTAAACAGATGTCTGCAGTTATAAATGTCATAAGTAGAGGTACAATCTCACCC
TGCTCCTTAGAAACATTTCCATATAAATCGCTAAAATAATTTCACATTTTTGTTAGTTTAATATATACATGAGTTTATTTCTGATATAAA
TAATAAATACAGAGAGTGAGCATATCAGAGAGGCAAATTCTTAAAGAATGATTTTTAAAATCAGCTCTAGGAAGAGCTCAAGATCAATTG
GTCATAGAACAGCATTTGACGCCTAGAACTATGACCACCTCATGGTCAGAGATGAGAATGTAGCCTTTGTGACCAGATTATATTATTTTT
AAATGAAGAAGCACTCATTAAATAAAACATAATTTTAAAAAACAATATAAGAAACAAAGTCAACTGAATCTTTTATTCATAGAAATGAAA
AGGAAAATAAAAACTGTGGCTGACCAAAAGGTCTTCTTGTTGTCCATAAAAGGATAAGGTAAACAGTCCTTAGATAATTACAAAACTTTC
TACAAAAGTTAAAATGTTACATTACTATACGTATTCAGATTCACTTGTTAAAGTACTCTTAAATCATTCAAATCTGGAAACAAAAGCTGA
ACTTAACTCTTGCTCCCTCAAAAGAGAAACACAAGCATAAGTGCAGCTTCAAAAAAGGAAAATATTTTAGGCTTTGGTGGAAGGGTGGAG
TTTAGATAAAATTTAAATGAAGTAGCGTTTTAATAGGTTCAAAGAAAAGTAAGGCAATGAGCAAACTCAAAGTACTGTCCTTGAAAACCA
TAGAGTCAAGATAAATGTATAGTGTATGGTTAGGTGGCAGAGAAATGCAATCATGTTGATAATCTTTGAGATACATCCTGTCATCAGTAT
ATTTCAGAATACATGCAATGCACTAGCAAGTTACAATTGATAGAATACATTTGAAATGTTAAATGAAATAAGCCAGGCACAGAAAGACAA
ACACCACATGATCTCACTCATATGTGGAATTTTAAAAAGTTGATCTCACTCATATGTGGAATTTTAAAAAGTTGATCTCACACAAGTAGA
GGGTAGAATCGTGGTTACCAGGGGCTAGGGAGAGAAAGAAGGCAGAGGCACTGAAAGATGTTGGTCAATGGGTATAAAGTTACACCTAGG
AAGAATAAATTTTGGTATTCACCACAGTAGGGTGACTATAGCAAATAATAATGTAGCATGTATTTCAAGATAGCTAGAAAAGCAGGTTTT
TAAATGTCACCACAAAGAAATAACAAATGTTTATAGTGGTGGATATGGTAATTACGCCTATTTGATCATTATACTGTGTGTACATGCATT

>10161_10161_5_BRCC3-CLIC2_BRCC3_chrX_154319114_ENST00000399042_CLIC2_chrX_154509357_ENST00000369449_length(amino acids)=332AA_BP=183
MAVQVVQAVQAVHLESDAFLVCLNHALSTEKEEVMGLCIGEVSSPSRSDSKFAYTGTEMRTVAEKVDAVRIVHIHSVIILRRSDKRKDRV
EISPEQLSAASTETHRLAELTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIFSCFIEDKNTKTGRVLYTCFQSIQAQK
SSEYPHLSPKYKESFDVGCNLFAKFSAYIKNTQKEANKNFEKSLLKEFKRLDDYLNTPLLDEIDPDSAEEPPVSRRLFLDGDQLTLADCS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for BRCC3-CLIC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BRCC3-CLIC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BRCC3-CLIC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource