Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ZNF207-SSU72 (FusionGDB2 ID:101617)

Fusion Gene Summary for ZNF207-SSU72

Fusion gene summary

Fusion gene information	Fusion gene name: ZNF207-SSU72
	Fusion gene ID: 101617
		Hgene	Tgene
	Gene symbol	ZNF207	SSU72
	Gene ID	7756	29101
	Gene name	zinc finger protein 207	SSU72 homolog, RNA polymerase II CTD phosphatase
	Synonyms	BuGZ\|hBuGZ	HSPC182\|PNAS-120
	Cytomap	17q11.2	1p36.33
	Type of gene	protein-coding	protein-coding
	Description	BUB3-interacting and GLEBS motif-containing protein ZNF207	RNA polymerase II subunit A C-terminal domain phosphatase SSU72CTD phosphatase SSU72
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000321233, ENST00000341711, ENST00000394670, ENST00000394673, ENST00000577908, ENST00000342555, ENST00000584416,	ENST00000359060, ENST00000291386,
Fusion gene scores	* DoF score	14 X 15 X 10=2100	14 X 7 X 10=980
	# samples	17	17
	** MAII score	log2(17/2100*10)=-3.62678267641578 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(17/980*10)=-2.52724700286487 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ZNF207 [Title/Abstract] AND SSU72 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ZNF207(30677345)-SSU72(1480382), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ZNF207	GO:0090307	mitotic spindle assembly	26388440
Tgene	SSU72	GO:0070940	dephosphorylation of RNA polymerase II C-terminal domain	20861839

Fusion gene breakpoints across ZNF207 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SSU72 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UVM	TCGA-YZ-A984	ZNF207	chr17	30677345	+	SSU72	chr1	1480382	-

Top

Fusion Gene ORF analysis for ZNF207-SSU72

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000321233	ENST00000359060	ZNF207	chr17	30677345	+	SSU72	chr1	1480382	-
5CDS-intron	ENST00000341711	ENST00000359060	ZNF207	chr17	30677345	+	SSU72	chr1	1480382	-
5CDS-intron	ENST00000394670	ENST00000359060	ZNF207	chr17	30677345	+	SSU72	chr1	1480382	-
5CDS-intron	ENST00000394673	ENST00000359060	ZNF207	chr17	30677345	+	SSU72	chr1	1480382	-
5CDS-intron	ENST00000577908	ENST00000359060	ZNF207	chr17	30677345	+	SSU72	chr1	1480382	-
5UTR-3CDS	ENST00000342555	ENST00000291386	ZNF207	chr17	30677345	+	SSU72	chr1	1480382	-
5UTR-intron	ENST00000342555	ENST00000359060	ZNF207	chr17	30677345	+	SSU72	chr1	1480382	-
In-frame	ENST00000321233	ENST00000291386	ZNF207	chr17	30677345	+	SSU72	chr1	1480382	-
In-frame	ENST00000341711	ENST00000291386	ZNF207	chr17	30677345	+	SSU72	chr1	1480382	-
In-frame	ENST00000394670	ENST00000291386	ZNF207	chr17	30677345	+	SSU72	chr1	1480382	-
In-frame	ENST00000394673	ENST00000291386	ZNF207	chr17	30677345	+	SSU72	chr1	1480382	-
In-frame	ENST00000577908	ENST00000291386	ZNF207	chr17	30677345	+	SSU72	chr1	1480382	-
intron-3CDS	ENST00000584416	ENST00000291386	ZNF207	chr17	30677345	+	SSU72	chr1	1480382	-
intron-intron	ENST00000584416	ENST00000359060	ZNF207	chr17	30677345	+	SSU72	chr1	1480382	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000394670	ZNF207	chr17	30677345	+	ENST00000291386	SSU72	chr1	1480382	-	964	210	169	570	133
ENST00000321233	ZNF207	chr17	30677345	+	ENST00000291386	SSU72	chr1	1480382	-	949	195	154	555	133
ENST00000394673	ZNF207	chr17	30677345	+	ENST00000291386	SSU72	chr1	1480382	-	943	189	148	549	133
ENST00000341711	ZNF207	chr17	30677345	+	ENST00000291386	SSU72	chr1	1480382	-	943	189	148	549	133
ENST00000577908	ZNF207	chr17	30677345	+	ENST00000291386	SSU72	chr1	1480382	-	901	147	106	507	133

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000394670	ENST00000291386	ZNF207	chr17	30677345	+	SSU72	chr1	1480382	-	0.012220399	0.9877796
ENST00000321233	ENST00000291386	ZNF207	chr17	30677345	+	SSU72	chr1	1480382	-	0.011338295	0.98866177
ENST00000394673	ENST00000291386	ZNF207	chr17	30677345	+	SSU72	chr1	1480382	-	0.01526186	0.9847381
ENST00000341711	ENST00000291386	ZNF207	chr17	30677345	+	SSU72	chr1	1480382	-	0.01526186	0.9847381
ENST00000577908	ENST00000291386	ZNF207	chr17	30677345	+	SSU72	chr1	1480382	-	0.013414283	0.98658574

Top

Fusion Genomic Features for ZNF207-SSU72

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for ZNF207-SSU72

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:30677345/chr1:1480382)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SSU72

chr17:30677345

chr1:1480382

ENST00000291386

160_186

195.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SSU72

chr17:30677345

chr1:1480382

ENST00000359060

160_186

154.0

Coiled coil

Ontology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ZNF207

chr17:30677345

chr1:1480382

ENST00000321233

1_92

479.0

Region

Microtubule-binding region

Hgene

ZNF207

chr17:30677345

chr1:1480382

ENST00000321233

359_391

479.0

Region

GLEBS

Hgene

ZNF207

chr17:30677345

chr1:1480382

ENST00000341711

1_92

396.0

Region

Microtubule-binding region

Hgene

ZNF207

chr17:30677345

chr1:1480382

ENST00000341711

359_391

396.0

Region

GLEBS

Hgene

ZNF207

chr17:30677345

chr1:1480382

ENST00000394670

1_92

495.0

Region

Microtubule-binding region

Hgene

ZNF207

chr17:30677345

chr1:1480382

ENST00000394670

359_391

495.0

Region

GLEBS

Hgene

ZNF207

chr17:30677345

chr1:1480382

ENST00000394673

1_92

464.0

Region

Microtubule-binding region

Hgene

ZNF207

chr17:30677345

chr1:1480382

ENST00000394673

359_391

464.0

Region

GLEBS

Hgene

ZNF207

chr17:30677345

chr1:1480382

ENST00000321233

11_34

479.0

Zinc finger

Note=C2H2-type 1

Hgene

ZNF207

chr17:30677345

chr1:1480382

ENST00000321233

35_58

479.0

Zinc finger

Note=C2H2-type 2

Hgene

ZNF207

chr17:30677345

chr1:1480382

ENST00000341711

11_34

396.0

Zinc finger

Note=C2H2-type 1

Hgene

ZNF207

chr17:30677345

chr1:1480382

ENST00000341711

35_58

396.0

Zinc finger

Note=C2H2-type 2

Hgene

ZNF207

chr17:30677345

chr1:1480382

ENST00000394670

11_34

495.0

Zinc finger

Note=C2H2-type 1

Hgene

ZNF207

chr17:30677345

chr1:1480382

ENST00000394670

35_58

495.0

Zinc finger

Note=C2H2-type 2

Hgene

ZNF207

chr17:30677345

chr1:1480382

ENST00000394673

11_34

464.0

Zinc finger

Note=C2H2-type 1

Hgene

ZNF207

chr17:30677345

chr1:1480382

ENST00000394673

35_58

464.0

Zinc finger

Note=C2H2-type 2

Top

Fusion Gene Sequence for ZNF207-SSU72

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>101617_101617_1_ZNF207-SSU72_ZNF207_chr17_30677345_ENST00000321233_SSU72_chr1_1480382_ENST00000291386_length(transcript)=949nt_BP=195nt
GGGAGGCGGAGCGGGGAACGAGGCCGTCGGCCATTTTGTGTCTGCTTCCTGTGGGACGTGGTGGTAGCCGTTGGGTTGGGAAAGTGAGGG
ATTTTTGGCCTCGTTTCTCCTGCTTCTTTTCTCCTCCCTTTTACTTTGCCGGTAGAACACAGTTATGGGTCGCAAGAAGAAGAAGCAGCT
GAAGCCGTGGTGCTGCTATACACAGAATGGGATTTTACATATGCTGGACAGAAATAAGAGAATCAAGCCCCGGCCAGAAAGATTCCAGAA
CTGCAAAGACCTGTTTGATCTGATCCTCACTTGCGAAGAGAGAGTGTATGACCAGGTGGTGGAAGATCTGAATTCCAGAGAACAGGAGAC
CTGCCAGCCTGTGCACGTGGTCAATGTGGACATCCAGGACAACCACGAGGAGGCCACCCTGGGGGCGTTTCTCATCTGTGAGCTCTGCCA
GTGTATCCAGCACACGGAAGACATGGAGAACGAGATCGACGAGCTGCTGCAGGAGTTCGAGGAGAAGAGTGGCCGCACCTTTCTGCACAC
CGTCTGCTTCTACTGAGCCCAGCGCCCGCATGGAGCCGCCTCTGGAGCTTCCTGTTGTTCATACTTTTTCCTTCCTGACATTTGTTTTTA
CTTACAGGTGTTCTGCTGGTGACGGTAGCATTACCCAAATAAACTGTGCATATGAAATGGGAGAGGAGATGCCAAAACGCCAGATGAAAG
CAATCAAGTTTCTTCTTTTCCACTTTTACTTATGAGCAGGATATTGATTACAAAGTTTTTCTTCTTTAACCAAAAAGGAAAGACAACGGT
TTGTGTGCACTTCCCGACATACCTGTGTCTTCGTGTGCCTGCCTTCCCTCCCTCCTCCCCACCGGGCCGGACTGTACAGAGCCCTGCTGC

>101617_101617_1_ZNF207-SSU72_ZNF207_chr17_30677345_ENST00000321233_SSU72_chr1_1480382_ENST00000291386_length(amino acids)=133AA_BP=8
MGRKKKKQLKPWCCYTQNGILHMLDRNKRIKPRPERFQNCKDLFDLILTCEERVYDQVVEDLNSREQETCQPVHVVNVDIQDNHEEATLG

--------------------------------------------------------------
>101617_101617_2_ZNF207-SSU72_ZNF207_chr17_30677345_ENST00000341711_SSU72_chr1_1480382_ENST00000291386_length(transcript)=943nt_BP=189nt
CGGAGCGGGGAACGAGGCCGTCGGCCATTTTGTGTCTGCTTCCTGTGGGACGTGGTGGTAGCCGTTGGGTTGGGAAAGTGAGGGATTTTT
GGCCTCGTTTCTCCTGCTTCTTTTCTCCTCCCTTTTACTTTGCCGGTAGAACACAGTTATGGGTCGCAAGAAGAAGAAGCAGCTGAAGCC
GTGGTGCTGCTATACACAGAATGGGATTTTACATATGCTGGACAGAAATAAGAGAATCAAGCCCCGGCCAGAAAGATTCCAGAACTGCAA
AGACCTGTTTGATCTGATCCTCACTTGCGAAGAGAGAGTGTATGACCAGGTGGTGGAAGATCTGAATTCCAGAGAACAGGAGACCTGCCA
GCCTGTGCACGTGGTCAATGTGGACATCCAGGACAACCACGAGGAGGCCACCCTGGGGGCGTTTCTCATCTGTGAGCTCTGCCAGTGTAT
CCAGCACACGGAAGACATGGAGAACGAGATCGACGAGCTGCTGCAGGAGTTCGAGGAGAAGAGTGGCCGCACCTTTCTGCACACCGTCTG
CTTCTACTGAGCCCAGCGCCCGCATGGAGCCGCCTCTGGAGCTTCCTGTTGTTCATACTTTTTCCTTCCTGACATTTGTTTTTACTTACA
GGTGTTCTGCTGGTGACGGTAGCATTACCCAAATAAACTGTGCATATGAAATGGGAGAGGAGATGCCAAAACGCCAGATGAAAGCAATCA
AGTTTCTTCTTTTCCACTTTTACTTATGAGCAGGATATTGATTACAAAGTTTTTCTTCTTTAACCAAAAAGGAAAGACAACGGTTTGTGT
GCACTTCCCGACATACCTGTGTCTTCGTGTGCCTGCCTTCCCTCCCTCCTCCCCACCGGGCCGGACTGTACAGAGCCCTGCTGCGGCGTG

>101617_101617_2_ZNF207-SSU72_ZNF207_chr17_30677345_ENST00000341711_SSU72_chr1_1480382_ENST00000291386_length(amino acids)=133AA_BP=8
MGRKKKKQLKPWCCYTQNGILHMLDRNKRIKPRPERFQNCKDLFDLILTCEERVYDQVVEDLNSREQETCQPVHVVNVDIQDNHEEATLG

--------------------------------------------------------------
>101617_101617_3_ZNF207-SSU72_ZNF207_chr17_30677345_ENST00000394670_SSU72_chr1_1480382_ENST00000291386_length(transcript)=964nt_BP=210nt
ACCGCAGTGCTTGACGGGAGGCGGAGCGGGGAACGAGGCCGTCGGCCATTTTGTGTCTGCTTCCTGTGGGACGTGGTGGTAGCCGTTGGG
TTGGGAAAGTGAGGGATTTTTGGCCTCGTTTCTCCTGCTTCTTTTCTCCTCCCTTTTACTTTGCCGGTAGAACACAGTTATGGGTCGCAA
GAAGAAGAAGCAGCTGAAGCCGTGGTGCTGCTATACACAGAATGGGATTTTACATATGCTGGACAGAAATAAGAGAATCAAGCCCCGGCC
AGAAAGATTCCAGAACTGCAAAGACCTGTTTGATCTGATCCTCACTTGCGAAGAGAGAGTGTATGACCAGGTGGTGGAAGATCTGAATTC
CAGAGAACAGGAGACCTGCCAGCCTGTGCACGTGGTCAATGTGGACATCCAGGACAACCACGAGGAGGCCACCCTGGGGGCGTTTCTCAT
CTGTGAGCTCTGCCAGTGTATCCAGCACACGGAAGACATGGAGAACGAGATCGACGAGCTGCTGCAGGAGTTCGAGGAGAAGAGTGGCCG
CACCTTTCTGCACACCGTCTGCTTCTACTGAGCCCAGCGCCCGCATGGAGCCGCCTCTGGAGCTTCCTGTTGTTCATACTTTTTCCTTCC
TGACATTTGTTTTTACTTACAGGTGTTCTGCTGGTGACGGTAGCATTACCCAAATAAACTGTGCATATGAAATGGGAGAGGAGATGCCAA
AACGCCAGATGAAAGCAATCAAGTTTCTTCTTTTCCACTTTTACTTATGAGCAGGATATTGATTACAAAGTTTTTCTTCTTTAACCAAAA
AGGAAAGACAACGGTTTGTGTGCACTTCCCGACATACCTGTGTCTTCGTGTGCCTGCCTTCCCTCCCTCCTCCCCACCGGGCCGGACTGT

>101617_101617_3_ZNF207-SSU72_ZNF207_chr17_30677345_ENST00000394670_SSU72_chr1_1480382_ENST00000291386_length(amino acids)=133AA_BP=8
MGRKKKKQLKPWCCYTQNGILHMLDRNKRIKPRPERFQNCKDLFDLILTCEERVYDQVVEDLNSREQETCQPVHVVNVDIQDNHEEATLG

--------------------------------------------------------------
>101617_101617_4_ZNF207-SSU72_ZNF207_chr17_30677345_ENST00000394673_SSU72_chr1_1480382_ENST00000291386_length(transcript)=943nt_BP=189nt
CGGAGCGGGGAACGAGGCCGTCGGCCATTTTGTGTCTGCTTCCTGTGGGACGTGGTGGTAGCCGTTGGGTTGGGAAAGTGAGGGATTTTT
GGCCTCGTTTCTCCTGCTTCTTTTCTCCTCCCTTTTACTTTGCCGGTAGAACACAGTTATGGGTCGCAAGAAGAAGAAGCAGCTGAAGCC
GTGGTGCTGCTATACACAGAATGGGATTTTACATATGCTGGACAGAAATAAGAGAATCAAGCCCCGGCCAGAAAGATTCCAGAACTGCAA
AGACCTGTTTGATCTGATCCTCACTTGCGAAGAGAGAGTGTATGACCAGGTGGTGGAAGATCTGAATTCCAGAGAACAGGAGACCTGCCA
GCCTGTGCACGTGGTCAATGTGGACATCCAGGACAACCACGAGGAGGCCACCCTGGGGGCGTTTCTCATCTGTGAGCTCTGCCAGTGTAT
CCAGCACACGGAAGACATGGAGAACGAGATCGACGAGCTGCTGCAGGAGTTCGAGGAGAAGAGTGGCCGCACCTTTCTGCACACCGTCTG
CTTCTACTGAGCCCAGCGCCCGCATGGAGCCGCCTCTGGAGCTTCCTGTTGTTCATACTTTTTCCTTCCTGACATTTGTTTTTACTTACA
GGTGTTCTGCTGGTGACGGTAGCATTACCCAAATAAACTGTGCATATGAAATGGGAGAGGAGATGCCAAAACGCCAGATGAAAGCAATCA
AGTTTCTTCTTTTCCACTTTTACTTATGAGCAGGATATTGATTACAAAGTTTTTCTTCTTTAACCAAAAAGGAAAGACAACGGTTTGTGT
GCACTTCCCGACATACCTGTGTCTTCGTGTGCCTGCCTTCCCTCCCTCCTCCCCACCGGGCCGGACTGTACAGAGCCCTGCTGCGGCGTG

>101617_101617_4_ZNF207-SSU72_ZNF207_chr17_30677345_ENST00000394673_SSU72_chr1_1480382_ENST00000291386_length(amino acids)=133AA_BP=8
MGRKKKKQLKPWCCYTQNGILHMLDRNKRIKPRPERFQNCKDLFDLILTCEERVYDQVVEDLNSREQETCQPVHVVNVDIQDNHEEATLG

--------------------------------------------------------------
>101617_101617_5_ZNF207-SSU72_ZNF207_chr17_30677345_ENST00000577908_SSU72_chr1_1480382_ENST00000291386_length(transcript)=901nt_BP=147nt
CTGTGGGACGTGGTGGTAGCCGTTGGGTTGGGAAAGTGAGGGATTTTTGGCCTCGTTTCTCCTGCTTCTTTTCTCCTCCCTTTTACTTTG
CCGGTAGAACACAGTTATGGGTCGCAAGAAGAAGAAGCAGCTGAAGCCGTGGTGCTGCTATACACAGAATGGGATTTTACATATGCTGGA
CAGAAATAAGAGAATCAAGCCCCGGCCAGAAAGATTCCAGAACTGCAAAGACCTGTTTGATCTGATCCTCACTTGCGAAGAGAGAGTGTA
TGACCAGGTGGTGGAAGATCTGAATTCCAGAGAACAGGAGACCTGCCAGCCTGTGCACGTGGTCAATGTGGACATCCAGGACAACCACGA
GGAGGCCACCCTGGGGGCGTTTCTCATCTGTGAGCTCTGCCAGTGTATCCAGCACACGGAAGACATGGAGAACGAGATCGACGAGCTGCT
GCAGGAGTTCGAGGAGAAGAGTGGCCGCACCTTTCTGCACACCGTCTGCTTCTACTGAGCCCAGCGCCCGCATGGAGCCGCCTCTGGAGC
TTCCTGTTGTTCATACTTTTTCCTTCCTGACATTTGTTTTTACTTACAGGTGTTCTGCTGGTGACGGTAGCATTACCCAAATAAACTGTG
CATATGAAATGGGAGAGGAGATGCCAAAACGCCAGATGAAAGCAATCAAGTTTCTTCTTTTCCACTTTTACTTATGAGCAGGATATTGAT
TACAAAGTTTTTCTTCTTTAACCAAAAAGGAAAGACAACGGTTTGTGTGCACTTCCCGACATACCTGTGTCTTCGTGTGCCTGCCTTCCC
TCCCTCCTCCCCACCGGGCCGGACTGTACAGAGCCCTGCTGCGGCGTGTTAGGAATGACCTGGAATTGTCAATAAACAGATGCTGCTGTC

>101617_101617_5_ZNF207-SSU72_ZNF207_chr17_30677345_ENST00000577908_SSU72_chr1_1480382_ENST00000291386_length(amino acids)=133AA_BP=8
MGRKKKKQLKPWCCYTQNGILHMLDRNKRIKPRPERFQNCKDLFDLILTCEERVYDQVVEDLNSREQETCQPVHVVNVDIQDNHEEATLG

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ZNF207-SSU72

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ZNF207-SSU72

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ZNF207-SSU72

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source