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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF222-PSG5 (FusionGDB2 ID:101642)

Fusion Gene Summary for ZNF222-PSG5

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF222-PSG5
Fusion gene ID: 101642
HgeneTgene
Gene symbol

ZNF222

PSG5

Gene ID

7673

5673

Gene namezinc finger protein 222pregnancy specific beta-1-glycoprotein 5
Synonyms-FL-NCA-3|PSG
Cytomap

19q13.31

19q13.31

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 222pregnancy-specific beta-1-glycoprotein 5PS-beta-G-5PSBG-5Pregnancy-specific beta-1-glycoprotein-5fetal liver non-specific cross-reactive antigen 3pregnancy-specific beta 1 glycoproteinpregnancy-specific glycoprotein 5
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000590160, ENST00000391960, 
ENST00000587846, ENST00000187879, 
ENST00000342951, ENST00000366175, 
ENST00000404580, ENST00000407356, 
ENST00000407568, ENST00000599812, 
ENST00000401992, 
Fusion gene scores* DoF score3 X 1 X 1=31 X 1 X 1=1
# samples 21
** MAII scorelog2(2/3*10)=2.73696559416621log2(1/1*10)=3.32192809488736
Context

PubMed: ZNF222 [Title/Abstract] AND PSG5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF222(44531642)-PSG5(43689299), # samples:3
Anticipated loss of major functional domain due to fusion event.ZNF222-PSG5 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ZNF222 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PSG5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-AJ-A3TW-01AZNF222chr19

44531642

-PSG5chr19

43689299

-
ChimerDB4UCECTCGA-AJ-A3TW-01AZNF222chr19

44531642

+PSG5chr19

43689299

-


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Fusion Gene ORF analysis for ZNF222-PSG5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000590160ENST00000342951ZNF222chr19

44531642

+PSG5chr19

43689299

-
3UTR-3CDSENST00000590160ENST00000366175ZNF222chr19

44531642

+PSG5chr19

43689299

-
3UTR-3CDSENST00000590160ENST00000404580ZNF222chr19

44531642

+PSG5chr19

43689299

-
3UTR-3CDSENST00000590160ENST00000407356ZNF222chr19

44531642

+PSG5chr19

43689299

-
3UTR-3CDSENST00000590160ENST00000407568ZNF222chr19

44531642

+PSG5chr19

43689299

-
3UTR-3CDSENST00000590160ENST00000599812ZNF222chr19

44531642

+PSG5chr19

43689299

-
3UTR-5UTRENST00000590160ENST00000401992ZNF222chr19

44531642

+PSG5chr19

43689299

-
5CDS-5UTRENST00000391960ENST00000401992ZNF222chr19

44531642

+PSG5chr19

43689299

-
5CDS-5UTRENST00000587846ENST00000401992ZNF222chr19

44531642

+PSG5chr19

43689299

-
Frame-shiftENST00000391960ENST00000342951ZNF222chr19

44531642

+PSG5chr19

43689299

-
Frame-shiftENST00000391960ENST00000366175ZNF222chr19

44531642

+PSG5chr19

43689299

-
Frame-shiftENST00000391960ENST00000407356ZNF222chr19

44531642

+PSG5chr19

43689299

-
Frame-shiftENST00000391960ENST00000407568ZNF222chr19

44531642

+PSG5chr19

43689299

-
Frame-shiftENST00000391960ENST00000599812ZNF222chr19

44531642

+PSG5chr19

43689299

-
Frame-shiftENST00000587846ENST00000342951ZNF222chr19

44531642

+PSG5chr19

43689299

-
Frame-shiftENST00000587846ENST00000366175ZNF222chr19

44531642

+PSG5chr19

43689299

-
Frame-shiftENST00000587846ENST00000407356ZNF222chr19

44531642

+PSG5chr19

43689299

-
Frame-shiftENST00000587846ENST00000407568ZNF222chr19

44531642

+PSG5chr19

43689299

-
Frame-shiftENST00000587846ENST00000599812ZNF222chr19

44531642

+PSG5chr19

43689299

-
In-frameENST00000391960ENST00000404580ZNF222chr19

44531642

+PSG5chr19

43689299

-
In-frameENST00000587846ENST00000404580ZNF222chr19

44531642

+PSG5chr19

43689299

-
intron-3CDSENST00000187879ENST00000342951ZNF222chr19

44531642

+PSG5chr19

43689299

-
intron-3CDSENST00000187879ENST00000366175ZNF222chr19

44531642

+PSG5chr19

43689299

-
intron-3CDSENST00000187879ENST00000404580ZNF222chr19

44531642

+PSG5chr19

43689299

-
intron-3CDSENST00000187879ENST00000407356ZNF222chr19

44531642

+PSG5chr19

43689299

-
intron-3CDSENST00000187879ENST00000407568ZNF222chr19

44531642

+PSG5chr19

43689299

-
intron-3CDSENST00000187879ENST00000599812ZNF222chr19

44531642

+PSG5chr19

43689299

-
intron-5UTRENST00000187879ENST00000401992ZNF222chr19

44531642

+PSG5chr19

43689299

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000587846ZNF222chr1944531642+ENST00000404580PSG5chr1943689299-2349357261294422
ENST00000391960ZNF222chr1944531642+ENST00000404580PSG5chr1943689299-2291299371236399

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000587846ENST00000404580ZNF222chr1944531642+PSG5chr1943689299-0.0017418590.9982582
ENST00000391960ENST00000404580ZNF222chr1944531642+PSG5chr1943689299-0.0020401830.99795985

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Fusion Genomic Features for ZNF222-PSG5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF222-PSG5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:44531642/chr19:43689299)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF222chr19:44531642chr19:43689299ENST00000391960+348_8587492.0DomainKRAB
TgenePSG5chr19:44531642chr19:43689299ENST0000034295106147_23421335.3333333333333DomainNote=Ig-like C2-type 1
TgenePSG5chr19:44531642chr19:43689299ENST0000034295106239_31721335.3333333333333DomainNote=Ig-like C2-type 2
TgenePSG5chr19:44531642chr19:43689299ENST000003429510635_14421335.3333333333333DomainNote=Ig-like V-type
TgenePSG5chr19:44531642chr19:43689299ENST0000036617506147_23421372.6666666666667DomainNote=Ig-like C2-type 1
TgenePSG5chr19:44531642chr19:43689299ENST0000036617506239_31721372.6666666666667DomainNote=Ig-like C2-type 2
TgenePSG5chr19:44531642chr19:43689299ENST000003661750635_14421372.6666666666667DomainNote=Ig-like V-type
TgenePSG5chr19:44531642chr19:43689299ENST0000040735606147_23421323.3333333333333DomainNote=Ig-like C2-type 1
TgenePSG5chr19:44531642chr19:43689299ENST0000040735606239_31721323.3333333333333DomainNote=Ig-like C2-type 2
TgenePSG5chr19:44531642chr19:43689299ENST000004073560635_14421323.3333333333333DomainNote=Ig-like V-type
TgenePSG5chr19:44531642chr19:43689299ENST0000034295106127_12921335.3333333333333MotifCell attachment site
TgenePSG5chr19:44531642chr19:43689299ENST0000036617506127_12921372.6666666666667MotifCell attachment site
TgenePSG5chr19:44531642chr19:43689299ENST0000040735606127_12921323.3333333333333MotifCell attachment site

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF222chr19:44531642chr19:43689299ENST00000187879+148_850452.0DomainKRAB
HgeneZNF222chr19:44531642chr19:43689299ENST00000187879+14145_1670452.0Zinc fingerC2H2-type 1
HgeneZNF222chr19:44531642chr19:43689299ENST00000187879+14173_1950452.0Zinc fingerC2H2-type 2
HgeneZNF222chr19:44531642chr19:43689299ENST00000187879+14201_2230452.0Zinc fingerC2H2-type 3
HgeneZNF222chr19:44531642chr19:43689299ENST00000187879+14229_2510452.0Zinc fingerC2H2-type 4
HgeneZNF222chr19:44531642chr19:43689299ENST00000187879+14257_2790452.0Zinc fingerC2H2-type 5
HgeneZNF222chr19:44531642chr19:43689299ENST00000187879+14285_3070452.0Zinc fingerC2H2-type 6%3B degenerate
HgeneZNF222chr19:44531642chr19:43689299ENST00000187879+14313_3350452.0Zinc fingerC2H2-type 7
HgeneZNF222chr19:44531642chr19:43689299ENST00000187879+14341_3630452.0Zinc fingerC2H2-type 8
HgeneZNF222chr19:44531642chr19:43689299ENST00000187879+14369_3910452.0Zinc fingerC2H2-type 9
HgeneZNF222chr19:44531642chr19:43689299ENST00000187879+14397_4190452.0Zinc fingerC2H2-type 10%3B degenerate
HgeneZNF222chr19:44531642chr19:43689299ENST00000391960+34145_16787492.0Zinc fingerC2H2-type 1
HgeneZNF222chr19:44531642chr19:43689299ENST00000391960+34173_19587492.0Zinc fingerC2H2-type 2
HgeneZNF222chr19:44531642chr19:43689299ENST00000391960+34201_22387492.0Zinc fingerC2H2-type 3
HgeneZNF222chr19:44531642chr19:43689299ENST00000391960+34229_25187492.0Zinc fingerC2H2-type 4
HgeneZNF222chr19:44531642chr19:43689299ENST00000391960+34257_27987492.0Zinc fingerC2H2-type 5
HgeneZNF222chr19:44531642chr19:43689299ENST00000391960+34285_30787492.0Zinc fingerC2H2-type 6%3B degenerate
HgeneZNF222chr19:44531642chr19:43689299ENST00000391960+34313_33587492.0Zinc fingerC2H2-type 7
HgeneZNF222chr19:44531642chr19:43689299ENST00000391960+34341_36387492.0Zinc fingerC2H2-type 8
HgeneZNF222chr19:44531642chr19:43689299ENST00000391960+34369_39187492.0Zinc fingerC2H2-type 9
HgeneZNF222chr19:44531642chr19:43689299ENST00000391960+34397_41987492.0Zinc fingerC2H2-type 10%3B degenerate


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Fusion Gene Sequence for ZNF222-PSG5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>101642_101642_1_ZNF222-PSG5_ZNF222_chr19_44531642_ENST00000391960_PSG5_chr19_43689299_ENST00000404580_length(transcript)=2291nt_BP=299nt
GAACGAGTCTCCTTTCCTTGGGGCTCGCAACCACCCAATGATCGATTCAGGAGAAAAGAAGCCTGGGCGGAGAGCAGAGGAGGCAGTGAC
CTTCAAGGATGTGGCTGTGATCTTCACTGAGGAGGAGCTGGGGCTGCTGGACCCTGCCCAGAGGAAGCTGTACCGAGATGTGATGCTTGA
GAACTTCAGGAACCTGCTCTCAGTGGGGCATCAACCATTCCATGGAGATACTTTCCACTTCCTAAGGGAAGAAAAGTTTTGGGTGATGGG
GACAACAAGCCAAAGAGAAGGGAATTTGGCATCACTTTTAAACTTCTGGAACCTGCCTATCACTGCTCAAGTCACGATTGAAGCCCTGCC
ACCCAAAGTTTCCGAGGGGAAGGATGTTCTTCTACTTGTCCACAATTTGCCTCAGAATCTTGCTGGCTACATCTGGTACAAAGGACAACT
GATGGACCTCTACCATTACATTACATCATATGTAGTAGACGGTCAAATAAATATATATGGGCCTGCATACACTGGACGAGAAACAGTATA
TTCCAATGCATCCCTGCTGATCCAGAATGTCACCCGGGAAGACGCAGGATCCTACACCTTACACATCATAAAGCGAGGTGATAGGACTAG
AGGAGTAACTGGATATTTCACCTTCAACTTATACCTGAAGCTGCCCAAGCCCTACATCACCATCAACAACTCAAAACCCAGGGAGAATAA
GGATGTCTTAGCCTTCACCTGTGAACCTAAGAGTGAGAACTACACCTACATTTGGTGGCTAAATGGTCAGAGCCTCCCGGTCAGTCCCAG
GGTAAAGCGACCCATTGAAAACAGGATCCTCATTCTACCCAGTGTCACGAGAAATGAAACAGGACCCTATGAATGTGAAATACGGGACCG
AGATGGTGGCATGCGCAGTGACCCAGTCACCCTGAATGTCCTCTATGGTCCAGACCTCCCCAGCATTTACCCTTCATTCACCTATTACCG
TTCAGGAGAAAACCTCTACTTGTCCTGCTTCGCGGAATCTAACCCACCGGCAGAGTATTTTTGGACAATTAATGGGAAGTTTCAGCAATC
AGGACAAAAGCTCTCTATCCCCCAAATTACTACAAAGCATAGAGGGCTCTATACTTGCTCTGTTCGTAACTCAGCTACTGGCAAGGAAAG
CTCCAAATCCATGACAGTCGAAGTCTCTGGTAAGTGGATCCCAGCATCCTTGGCAATAGGGTTTTAGGTGGAGTCTACCTGGCTTTCAGA
GAAGAGTTAGGAAAACATTTTTATTCCCAGCCTGTGTCCCATGGGCACAAGCAAATCCCAAATTCTCCTCCTGAACCCTTCCAATTTGTC
TCTACAAACTCTCTTCTCCTTGTTTTTCTGTTTTCTCATGGCTGACCTTGTGTCTGGCCTAAGAAAGTTAGGGAGGGGGCTTTATCAGCC
CTGAGCCCTATGTGGTAGAGGAGGCTTCACAGAGGGATGAGAAGGAGAGTCCTCAAGATCAAGTTGCTTCTCGATGTCACCAACACATCC
CCTTCTGCCATGTCTTTGTTTCCTTGTACCTATTCCATGAGCTACAAGGAACATCTGAGGCTCTGAAACAAGCTCACACTTTTCCCCCAA
ATGAGACGAGGAAGCCCCTTGGGTGAGGGAGGAGCAGCTCAGACTCTGCTTCCTGCTCTGCTCCATGCTTCTCTGGTGACTGGGCCTGCC
TCACTCAACCTGGGGTGGGACCAGCATGTGTGGAGAAAGAGTCCTGGTGGCCTGTCCTGAATTTGGCTAAATCGAGCTGCCAGTTGAAGC
CAAGCCTCCCCCGGGCCAGGCTGCAGGGAAATAAGAAGAGAGGGAGCCTCAGGGAAGACTCCTGCGTTGCGTCCTGGCTCTGAAGTCACC
GGTTGTATGAGGTTGTGGGCACAGCATGTGGGACACAGCACGGAGGATAGTGACTGATGCAGAGCTGGAGAAATAGAGAGATTCACCCCT
GGGGCTCTGCATGGCAGGAAAGGGGCAGTGCCAAAAAGTGTGTAATTATAGAGAGGGTAAGACTACCAGACACTTTATATATATCTAATA
TAAGACTTACCATTAACTATTTCTATGTGTGCAATTTAGTGTTGTGTAACCATCACACTATCCATTTCCAGAACTTTTTCCTCTTACCAT
ATTAAACCTCTGTACCCAATAAACAGTAACTCACTCCTTCTCCCCATAACCCTTAGCACACACCATTCTACATTCTGTCTCTATGTAACT

>101642_101642_1_ZNF222-PSG5_ZNF222_chr19_44531642_ENST00000391960_PSG5_chr19_43689299_ENST00000404580_length(amino acids)=399AA_BP=14
MIDSGEKKPGRRAEEAVTFKDVAVIFTEEELGLLDPAQRKLYRDVMLENFRNLLSVGHQPFHGDTFHFLREEKFWVMGTTSQREGNLASL
LNFWNLPITAQVTIEALPPKVSEGKDVLLLVHNLPQNLAGYIWYKGQLMDLYHYITSYVVDGQINIYGPAYTGRETVYSNASLLIQNVTR
EDAGSYTLHIIKRGDRTRGVTGYFTFNLYLKLPKPYITINNSKPRENKDVLAFTCEPKSENYTYIWWLNGQSLPVSPRVKRPIENRILIL
PSVTRNETGPYECEIRDRDGGMRSDPVTLNVLYGPDLPSIYPSFTYYRSGENLYLSCFAESNPPAEYFWTINGKFQQSGQKLSIPQITTK

--------------------------------------------------------------
>101642_101642_2_ZNF222-PSG5_ZNF222_chr19_44531642_ENST00000587846_PSG5_chr19_43689299_ENST00000404580_length(transcript)=2349nt_BP=357nt
GTTGCTATTTCATTTACCACAGTAGTTTGAGTCATTTCCACATCTTGCGAGTCCTTCCGAACGAGTCTCCTTTCCTTGGGGCTCGCAACC
ACCCAATGATCGATTCAGGAGAAAAGAAGCCTGGGCGGAGAGCAGAGGAGGCAGTGACCTTCAAGGATGTGGCTGTGATCTTCACTGAGG
AGGAGCTGGGGCTGCTGGACCCTGCCCAGAGGAAGCTGTACCGAGATGTGATGCTTGAGAACTTCAGGAACCTGCTCTCAGTGGGGCATC
AACCATTCCATGGAGATACTTTCCACTTCCTAAGGGAAGAAAAGTTTTGGGTGATGGGGACAACAAGCCAAAGAGAAGGGAATTTGGCAT
CACTTTTAAACTTCTGGAACCTGCCTATCACTGCTCAAGTCACGATTGAAGCCCTGCCACCCAAAGTTTCCGAGGGGAAGGATGTTCTTC
TACTTGTCCACAATTTGCCTCAGAATCTTGCTGGCTACATCTGGTACAAAGGACAACTGATGGACCTCTACCATTACATTACATCATATG
TAGTAGACGGTCAAATAAATATATATGGGCCTGCATACACTGGACGAGAAACAGTATATTCCAATGCATCCCTGCTGATCCAGAATGTCA
CCCGGGAAGACGCAGGATCCTACACCTTACACATCATAAAGCGAGGTGATAGGACTAGAGGAGTAACTGGATATTTCACCTTCAACTTAT
ACCTGAAGCTGCCCAAGCCCTACATCACCATCAACAACTCAAAACCCAGGGAGAATAAGGATGTCTTAGCCTTCACCTGTGAACCTAAGA
GTGAGAACTACACCTACATTTGGTGGCTAAATGGTCAGAGCCTCCCGGTCAGTCCCAGGGTAAAGCGACCCATTGAAAACAGGATCCTCA
TTCTACCCAGTGTCACGAGAAATGAAACAGGACCCTATGAATGTGAAATACGGGACCGAGATGGTGGCATGCGCAGTGACCCAGTCACCC
TGAATGTCCTCTATGGTCCAGACCTCCCCAGCATTTACCCTTCATTCACCTATTACCGTTCAGGAGAAAACCTCTACTTGTCCTGCTTCG
CGGAATCTAACCCACCGGCAGAGTATTTTTGGACAATTAATGGGAAGTTTCAGCAATCAGGACAAAAGCTCTCTATCCCCCAAATTACTA
CAAAGCATAGAGGGCTCTATACTTGCTCTGTTCGTAACTCAGCTACTGGCAAGGAAAGCTCCAAATCCATGACAGTCGAAGTCTCTGGTA
AGTGGATCCCAGCATCCTTGGCAATAGGGTTTTAGGTGGAGTCTACCTGGCTTTCAGAGAAGAGTTAGGAAAACATTTTTATTCCCAGCC
TGTGTCCCATGGGCACAAGCAAATCCCAAATTCTCCTCCTGAACCCTTCCAATTTGTCTCTACAAACTCTCTTCTCCTTGTTTTTCTGTT
TTCTCATGGCTGACCTTGTGTCTGGCCTAAGAAAGTTAGGGAGGGGGCTTTATCAGCCCTGAGCCCTATGTGGTAGAGGAGGCTTCACAG
AGGGATGAGAAGGAGAGTCCTCAAGATCAAGTTGCTTCTCGATGTCACCAACACATCCCCTTCTGCCATGTCTTTGTTTCCTTGTACCTA
TTCCATGAGCTACAAGGAACATCTGAGGCTCTGAAACAAGCTCACACTTTTCCCCCAAATGAGACGAGGAAGCCCCTTGGGTGAGGGAGG
AGCAGCTCAGACTCTGCTTCCTGCTCTGCTCCATGCTTCTCTGGTGACTGGGCCTGCCTCACTCAACCTGGGGTGGGACCAGCATGTGTG
GAGAAAGAGTCCTGGTGGCCTGTCCTGAATTTGGCTAAATCGAGCTGCCAGTTGAAGCCAAGCCTCCCCCGGGCCAGGCTGCAGGGAAAT
AAGAAGAGAGGGAGCCTCAGGGAAGACTCCTGCGTTGCGTCCTGGCTCTGAAGTCACCGGTTGTATGAGGTTGTGGGCACAGCATGTGGG
ACACAGCACGGAGGATAGTGACTGATGCAGAGCTGGAGAAATAGAGAGATTCACCCCTGGGGCTCTGCATGGCAGGAAAGGGGCAGTGCC
AAAAAGTGTGTAATTATAGAGAGGGTAAGACTACCAGACACTTTATATATATCTAATATAAGACTTACCATTAACTATTTCTATGTGTGC
AATTTAGTGTTGTGTAACCATCACACTATCCATTTCCAGAACTTTTTCCTCTTACCATATTAAACCTCTGTACCCAATAAACAGTAACTC
ACTCCTTCTCCCCATAACCCTTAGCACACACCATTCTACATTCTGTCTCTATGTAACTGGCTATTCTAACTATCTTTTATAAATGGAATT

>101642_101642_2_ZNF222-PSG5_ZNF222_chr19_44531642_ENST00000587846_PSG5_chr19_43689299_ENST00000404580_length(amino acids)=422AA_BP=37
MSHFHILRVLPNESPFLGARNHPMIDSGEKKPGRRAEEAVTFKDVAVIFTEEELGLLDPAQRKLYRDVMLENFRNLLSVGHQPFHGDTFH
FLREEKFWVMGTTSQREGNLASLLNFWNLPITAQVTIEALPPKVSEGKDVLLLVHNLPQNLAGYIWYKGQLMDLYHYITSYVVDGQINIY
GPAYTGRETVYSNASLLIQNVTREDAGSYTLHIIKRGDRTRGVTGYFTFNLYLKLPKPYITINNSKPRENKDVLAFTCEPKSENYTYIWW
LNGQSLPVSPRVKRPIENRILILPSVTRNETGPYECEIRDRDGGMRSDPVTLNVLYGPDLPSIYPSFTYYRSGENLYLSCFAESNPPAEY

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Fusion Gene PPI Analysis for ZNF222-PSG5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF222-PSG5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF222-PSG5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource