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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF223-AP2A1 (FusionGDB2 ID:101644)

Fusion Gene Summary for ZNF223-AP2A1

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF223-AP2A1
Fusion gene ID: 101644
HgeneTgene
Gene symbol

ZNF223

AP2A1

Gene ID

7766

160

Gene namezinc finger protein 223adaptor related protein complex 2 subunit alpha 1
Synonyms-ADTAA|AP2-ALPHA|CLAPA1
Cytomap

19q13.31

19q13.33

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 223Homo sapiens zinc finger protein 223KRAB A domainAP-2 complex subunit alpha-1100 kDa coated vesicle protein Aadapter-related protein complex 2 alpha-1 subunitadapter-related protein complex 2 subunit alpha-1adaptin, alpha Aadaptor protein complex AP-2 subunit alpha-1adaptor related protein complex
Modification date2020031320200313
UniProtAcc.

O95782

Ensembl transtripts involved in fusion geneENST00000588518, ENST00000434772, 
ENST00000585552, ENST00000591793, 
ENST00000354293, ENST00000359032, 
ENST00000600199, 
Fusion gene scores* DoF score2 X 2 X 2=813 X 12 X 6=936
# samples 215
** MAII scorelog2(2/8*10)=1.32192809488736log2(15/936*10)=-2.64154602908752
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF223 [Title/Abstract] AND AP2A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF223(44559344)-AP2A1(50298887), # samples:4
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneAP2A1

GO:0072583

clathrin-dependent endocytosis

23676497

TgeneAP2A1

GO:1900126

negative regulation of hyaluronan biosynthetic process

24251095


check buttonFusion gene breakpoints across ZNF223 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AP2A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-AB2Q-01AZNF223chr19

44559344

+AP2A1chr19

50298887

+
ChimerDB4SARCTCGA-QQ-A8VF-01AZNF223chr19

44559344

-AP2A1chr19

50298887

+
ChimerDB4SARCTCGA-QQ-A8VF-01AZNF223chr19

44559344

+AP2A1chr19

50298887

+


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Fusion Gene ORF analysis for ZNF223-AP2A1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000588518ENST00000354293ZNF223chr19

44559344

+AP2A1chr19

50298887

+
3UTR-3UTRENST00000588518ENST00000359032ZNF223chr19

44559344

+AP2A1chr19

50298887

+
3UTR-3UTRENST00000588518ENST00000600199ZNF223chr19

44559344

+AP2A1chr19

50298887

+
5CDS-3UTRENST00000434772ENST00000359032ZNF223chr19

44559344

+AP2A1chr19

50298887

+
5CDS-3UTRENST00000434772ENST00000600199ZNF223chr19

44559344

+AP2A1chr19

50298887

+
5CDS-3UTRENST00000585552ENST00000359032ZNF223chr19

44559344

+AP2A1chr19

50298887

+
5CDS-3UTRENST00000585552ENST00000600199ZNF223chr19

44559344

+AP2A1chr19

50298887

+
5CDS-3UTRENST00000591793ENST00000359032ZNF223chr19

44559344

+AP2A1chr19

50298887

+
5CDS-3UTRENST00000591793ENST00000600199ZNF223chr19

44559344

+AP2A1chr19

50298887

+
In-frameENST00000434772ENST00000354293ZNF223chr19

44559344

+AP2A1chr19

50298887

+
In-frameENST00000585552ENST00000354293ZNF223chr19

44559344

+AP2A1chr19

50298887

+
In-frameENST00000591793ENST00000354293ZNF223chr19

44559344

+AP2A1chr19

50298887

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000591793ZNF223chr1944559344+ENST00000354293AP2A1chr1950298887+2945428142590858
ENST00000434772ZNF223chr1944559344+ENST00000354293AP2A1chr1950298887+27872701952432745
ENST00000585552ZNF223chr1944559344+ENST00000354293AP2A1chr1950298887+27552381632400745

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000591793ENST00000354293ZNF223chr1944559344+AP2A1chr1950298887+0.0058327580.9941672
ENST00000434772ENST00000354293ZNF223chr1944559344+AP2A1chr1950298887+0.0122268360.9877731
ENST00000585552ENST00000354293ZNF223chr1944559344+AP2A1chr1950298887+0.0127615130.9872385

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Fusion Genomic Features for ZNF223-AP2A1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ZNF223chr1944559344+AP2A1chr1950298886+5.16E-091
ZNF223chr1944559344+AP2A1chr1950298886+5.16E-091
ZNF223chr1944559344+AP2A1chr1950298886+5.16E-091
ZNF223chr1944559344+AP2A1chr1950298886+5.16E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ZNF223-AP2A1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:44559344/chr19:50298887)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.AP2A1

O95782

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). {ECO:0000250, ECO:0000269|PubMed:14745134, ECO:0000269|PubMed:15473838, ECO:0000269|PubMed:19033387, ECO:0000269|PubMed:23676497}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF223chr19:44559344chr19:50298887ENST00000434772+258_785483.0DomainKRAB
HgeneZNF223chr19:44559344chr19:50298887ENST00000434772+25176_1985483.0Zinc fingerC2H2-type 1
HgeneZNF223chr19:44559344chr19:50298887ENST00000434772+25204_2265483.0Zinc fingerC2H2-type 2
HgeneZNF223chr19:44559344chr19:50298887ENST00000434772+25232_2545483.0Zinc fingerC2H2-type 3
HgeneZNF223chr19:44559344chr19:50298887ENST00000434772+25260_2825483.0Zinc fingerC2H2-type 4
HgeneZNF223chr19:44559344chr19:50298887ENST00000434772+25288_3105483.0Zinc fingerC2H2-type 5
HgeneZNF223chr19:44559344chr19:50298887ENST00000434772+25316_3385483.0Zinc fingerC2H2-type 6%3B degenerate
HgeneZNF223chr19:44559344chr19:50298887ENST00000434772+25344_3665483.0Zinc fingerC2H2-type 7
HgeneZNF223chr19:44559344chr19:50298887ENST00000434772+25372_3945483.0Zinc fingerC2H2-type 8
HgeneZNF223chr19:44559344chr19:50298887ENST00000434772+25400_4225483.0Zinc fingerC2H2-type 9
HgeneZNF223chr19:44559344chr19:50298887ENST00000434772+25428_4505483.0Zinc fingerC2H2-type 10%3B degenerate


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Fusion Gene Sequence for ZNF223-AP2A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>101644_101644_1_ZNF223-AP2A1_ZNF223_chr19_44559344_ENST00000434772_AP2A1_chr19_50298887_ENST00000354293_length(transcript)=2787nt_BP=270nt
GCGCAGAGAGGACACTTCCGGTCTCCTAGTCTGAGGTTCCTGCTTTAATGACCGGGGTAGTTTGAGCCATTTCTGCGTCTTGCAGGACAT
TTTGAACGAACCCCCTTTGCTTGAGGCTCGCAACCACCCGATGATCGATGATCGTCTCAGGGGAAAAGAAGCCTTGGCGAAGAGCAGAGG
TTTAGAGGCACAATTCTGCTTTCCCTGGAACTGTGTCATTCAGGACTCTGCAAATTCCCTAAAGTAGGAGGAAAAATGACCATGTCCAAG
ATCGTCTCCTCTGCCTCCACCGACCTCCAGGACTACACCTACTACTTCGTCCCAGCACCCTGGCTCTCGGTGAAGCTCCTGCGGCTGCTG
CAGTGCTACCCGCCTCCAGAGGATGCGGCTGTGAAGGGGCGGCTGGTGGAATGTCTGGAGACTGTGCTCAACAAGGCCCAGGAGCCCCCC
AAATCCAAGAAGGTGCAGCATTCCAACGCCAAGAACGCCATCCTCTTCGAGACCATCAGCCTCATCATCCACTATGACAGTGAGCCCAAC
CTCCTGGTTCGGGCCTGCAACCAGCTGGGCCAGTTCCTGCAGCACCGGGAGACCAACCTGCGCTACCTGGCCCTGGAGAGCATGTGCACG
CTGGCCAGCTCCGAGTTCTCCCATGAAGCCGTCAAGACGCACATTGACACCGTCATCAATGCCCTCAAGACGGAGCGGGACGTCAGCGTG
CGGCAGCGGGCGGCTGACCTCCTCTACGCCATGTGTGACCGGAGCAATGCCAAGCAGATCGTGTCGGAGATGCTGCGGTACCTGGAGACG
GCAGACTACGCCATCCGCGAGGAGATCGTCCTGAAGGTGGCCATCCTGGCCGAGAAGTACGCCGTGGACTACAGCTGGTACGTGGACACC
ATCCTCAACCTCATCCGCATTGCGGGCGACTACGTGAGTGAGGAGGTGTGGTACCGTGTGCTACAGATCGTCACCAACCGTGATGACGTC
CAGGGCTATGCCGCCAAGACCGTCTTTGAGGCGCTCCAGGCCCCTGCCTGTCACGAGAACATGGTGAAGGTTGGCGGCTACATCCTTGGG
GAGTTTGGGAACCTGATTGCTGGGGACCCCCGCTCCAGCCCCCCAGTGCAGTTCTCCCTGCTCCACTCCAAGTTCCATCTGTGCAGCGTG
GCCACGCGGGCGCTGCTGCTGTCCACCTACATCAAGTTCATCAACCTCTTCCCCGAGACCAAGGCCACCATCCAGGGCGTCCTGCGGGCC
GGCTCCCAGCTGCGCAATGCTGACGTGGAGCTGCAGCAGCGAGCCGTGGAGTACCTCACCCTCAGCTCAGTGGCCAGCACCGACGTCCTG
GCCACGGTGCTGGAGGAGATGCCGCCCTTCCCCGAGCGCGAGTCGTCCATCCTGGCCAAGCTGAAACGCAAGAAGGGGCCAGGGGCCGGC
AGCGCCCTGGACGATGGCCGGAGGGACCCCAGCAGCAACGACATCAACGGGGGCATGGAGCCCACCCCCAGCACTGTGTCGACGCCCTCG
CCCTCCGCCGACCTCCTGGGGCTGCGGGCAGCCCCTCCCCCGGCAGCACCCCCGGCTTCTGCAGGAGCAGGGAACCTTCTGGTGGACGTC
TTCGATGGCCCGGCCGCCCAGCCCAGCCTGGGGCCCACCCCCGAGGAGGCCTTCCTCAGCCCAGGTCCTGAGGACATCGGCCCTCCCATT
CCGGAAGCCGATGAGTTGCTGAATAAGTTTGTGTGTAAGAACAACGGGGTCCTGTTCGAGAACCAGCTGCTGCAGATCGGAGTCAAGTCA
GAGTTCCGACAGAACCTGGGCCGCATGTATCTCTTCTATGGCAACAAGACCTCGGTGCAGTTCCAGAATTTCTCACCCACTGTGGTTCAC
CCGGGAGACCTCCAGACTCAGCTGGCTGTGCAGACCAAGCGCGTGGCGGCGCAGGTGGACGGCGGCGCGCAGGTGCAGCAGGTGCTCAAT
ATCGAGTGCCTGCGGGACTTCCTGACGCCCCCGCTGCTGTCCGTGCGCTTCCGGTACGGTGGCGCCCCCCAGGCCCTCACCCTGAAGCTC
CCAGTGACCATCAACAAGTTCTTCCAGCCCACCGAGATGGCGGCCCAGGATTTCTTCCAGCGCTGGAAGCAGCTGAGCCTCCCTCAACAG
GAGGCGCAGAAAATCTTCAAAGCCAACCACCCCATGGACGCAGAAGTTACTAAGGCCAAGCTTCTGGGGTTTGGCTCTGCTCTCCTGGAC
AATGTGGACCCCAACCCTGAGAACTTCGTGGGGGCGGGGATCATCCAGACTAAAGCCCTGCAGGTGGGCTGTCTGCTTCGGCTGGAGCCC
AATGCCCAGGCCCAGATGTACCGGCTGACCCTGCGCACCAGCAAGGAGCCCGTCTCCCGTCACCTGTGTGAGCTGCTGGCACAGCAGTTC
TGAGCCCTGGACTCTGCCCCGGGGGATGTGGCCGGCACTGGGCAGCCCCTTGGACTGAGGCAGTTTTGGTGGATGGGGGACCTCCACTGG
TGACAGAGAAGACACCAGGGTTTGGGGGATGCCTGGGACTTTCCTCCGGCCTTTTGTATTTTTATTTTTGTTCATCTGCTGCTGTTTACA
TTCTGGGGGGTTAGGGGGAGTCCCCCTCCCTCCCTTTCCCCCCCAAGCACAGAGGGGAGAGGGGCCAGGGAAGTGGATGTCTCCTCCCCT

>101644_101644_1_ZNF223-AP2A1_ZNF223_chr19_44559344_ENST00000434772_AP2A1_chr19_50298887_ENST00000354293_length(amino acids)=745AA_BP=25
MLSLELCHSGLCKFPKVGGKMTMSKIVSSASTDLQDYTYYFVPAPWLSVKLLRLLQCYPPPEDAAVKGRLVECLETVLNKAQEPPKSKKV
QHSNAKNAILFETISLIIHYDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIDTVINALKTERDVSVRQRAA
DLLYAMCDRSNAKQIVSEMLRYLETADYAIREEIVLKVAILAEKYAVDYSWYVDTILNLIRIAGDYVSEEVWYRVLQIVTNRDDVQGYAA
KTVFEALQAPACHENMVKVGGYILGEFGNLIAGDPRSSPPVQFSLLHSKFHLCSVATRALLLSTYIKFINLFPETKATIQGVLRAGSQLR
NADVELQQRAVEYLTLSSVASTDVLATVLEEMPPFPERESSILAKLKRKKGPGAGSALDDGRRDPSSNDINGGMEPTPSTVSTPSPSADL
LGLRAAPPPAAPPASAGAGNLLVDVFDGPAAQPSLGPTPEEAFLSPGPEDIGPPIPEADELLNKFVCKNNGVLFENQLLQIGVKSEFRQN
LGRMYLFYGNKTSVQFQNFSPTVVHPGDLQTQLAVQTKRVAAQVDGGAQVQQVLNIECLRDFLTPPLLSVRFRYGGAPQALTLKLPVTIN
KFFQPTEMAAQDFFQRWKQLSLPQQEAQKIFKANHPMDAEVTKAKLLGFGSALLDNVDPNPENFVGAGIIQTKALQVGCLLRLEPNAQAQ

--------------------------------------------------------------
>101644_101644_2_ZNF223-AP2A1_ZNF223_chr19_44559344_ENST00000585552_AP2A1_chr19_50298887_ENST00000354293_length(transcript)=2755nt_BP=238nt
GAGGTTCCTGCTTTAATGACCGGGGTAGTTTGAGCCATTTCTGCGTCTTGCAGGACATTTTGAACGAACCCCCTTTGCTTGAGGCTCGCA
ACCACCCGATGATCGATGATCGTCTCAGGGGAAAAGAAGCCTTGGCGAAGAGCAGAGGTTTAGAGGCACAATTCTGCTTTCCCTGGAACT
GTGTCATTCAGGACTCTGCAAATTCCCTAAAGTAGGAGGAAAAATGACCATGTCCAAGATCGTCTCCTCTGCCTCCACCGACCTCCAGGA
CTACACCTACTACTTCGTCCCAGCACCCTGGCTCTCGGTGAAGCTCCTGCGGCTGCTGCAGTGCTACCCGCCTCCAGAGGATGCGGCTGT
GAAGGGGCGGCTGGTGGAATGTCTGGAGACTGTGCTCAACAAGGCCCAGGAGCCCCCCAAATCCAAGAAGGTGCAGCATTCCAACGCCAA
GAACGCCATCCTCTTCGAGACCATCAGCCTCATCATCCACTATGACAGTGAGCCCAACCTCCTGGTTCGGGCCTGCAACCAGCTGGGCCA
GTTCCTGCAGCACCGGGAGACCAACCTGCGCTACCTGGCCCTGGAGAGCATGTGCACGCTGGCCAGCTCCGAGTTCTCCCATGAAGCCGT
CAAGACGCACATTGACACCGTCATCAATGCCCTCAAGACGGAGCGGGACGTCAGCGTGCGGCAGCGGGCGGCTGACCTCCTCTACGCCAT
GTGTGACCGGAGCAATGCCAAGCAGATCGTGTCGGAGATGCTGCGGTACCTGGAGACGGCAGACTACGCCATCCGCGAGGAGATCGTCCT
GAAGGTGGCCATCCTGGCCGAGAAGTACGCCGTGGACTACAGCTGGTACGTGGACACCATCCTCAACCTCATCCGCATTGCGGGCGACTA
CGTGAGTGAGGAGGTGTGGTACCGTGTGCTACAGATCGTCACCAACCGTGATGACGTCCAGGGCTATGCCGCCAAGACCGTCTTTGAGGC
GCTCCAGGCCCCTGCCTGTCACGAGAACATGGTGAAGGTTGGCGGCTACATCCTTGGGGAGTTTGGGAACCTGATTGCTGGGGACCCCCG
CTCCAGCCCCCCAGTGCAGTTCTCCCTGCTCCACTCCAAGTTCCATCTGTGCAGCGTGGCCACGCGGGCGCTGCTGCTGTCCACCTACAT
CAAGTTCATCAACCTCTTCCCCGAGACCAAGGCCACCATCCAGGGCGTCCTGCGGGCCGGCTCCCAGCTGCGCAATGCTGACGTGGAGCT
GCAGCAGCGAGCCGTGGAGTACCTCACCCTCAGCTCAGTGGCCAGCACCGACGTCCTGGCCACGGTGCTGGAGGAGATGCCGCCCTTCCC
CGAGCGCGAGTCGTCCATCCTGGCCAAGCTGAAACGCAAGAAGGGGCCAGGGGCCGGCAGCGCCCTGGACGATGGCCGGAGGGACCCCAG
CAGCAACGACATCAACGGGGGCATGGAGCCCACCCCCAGCACTGTGTCGACGCCCTCGCCCTCCGCCGACCTCCTGGGGCTGCGGGCAGC
CCCTCCCCCGGCAGCACCCCCGGCTTCTGCAGGAGCAGGGAACCTTCTGGTGGACGTCTTCGATGGCCCGGCCGCCCAGCCCAGCCTGGG
GCCCACCCCCGAGGAGGCCTTCCTCAGCCCAGGTCCTGAGGACATCGGCCCTCCCATTCCGGAAGCCGATGAGTTGCTGAATAAGTTTGT
GTGTAAGAACAACGGGGTCCTGTTCGAGAACCAGCTGCTGCAGATCGGAGTCAAGTCAGAGTTCCGACAGAACCTGGGCCGCATGTATCT
CTTCTATGGCAACAAGACCTCGGTGCAGTTCCAGAATTTCTCACCCACTGTGGTTCACCCGGGAGACCTCCAGACTCAGCTGGCTGTGCA
GACCAAGCGCGTGGCGGCGCAGGTGGACGGCGGCGCGCAGGTGCAGCAGGTGCTCAATATCGAGTGCCTGCGGGACTTCCTGACGCCCCC
GCTGCTGTCCGTGCGCTTCCGGTACGGTGGCGCCCCCCAGGCCCTCACCCTGAAGCTCCCAGTGACCATCAACAAGTTCTTCCAGCCCAC
CGAGATGGCGGCCCAGGATTTCTTCCAGCGCTGGAAGCAGCTGAGCCTCCCTCAACAGGAGGCGCAGAAAATCTTCAAAGCCAACCACCC
CATGGACGCAGAAGTTACTAAGGCCAAGCTTCTGGGGTTTGGCTCTGCTCTCCTGGACAATGTGGACCCCAACCCTGAGAACTTCGTGGG
GGCGGGGATCATCCAGACTAAAGCCCTGCAGGTGGGCTGTCTGCTTCGGCTGGAGCCCAATGCCCAGGCCCAGATGTACCGGCTGACCCT
GCGCACCAGCAAGGAGCCCGTCTCCCGTCACCTGTGTGAGCTGCTGGCACAGCAGTTCTGAGCCCTGGACTCTGCCCCGGGGGATGTGGC
CGGCACTGGGCAGCCCCTTGGACTGAGGCAGTTTTGGTGGATGGGGGACCTCCACTGGTGACAGAGAAGACACCAGGGTTTGGGGGATGC
CTGGGACTTTCCTCCGGCCTTTTGTATTTTTATTTTTGTTCATCTGCTGCTGTTTACATTCTGGGGGGTTAGGGGGAGTCCCCCTCCCTC
CCTTTCCCCCCCAAGCACAGAGGGGAGAGGGGCCAGGGAAGTGGATGTCTCCTCCCCTCCCACCCCACCCTGTTGTAGCCCCTCCTACCC

>101644_101644_2_ZNF223-AP2A1_ZNF223_chr19_44559344_ENST00000585552_AP2A1_chr19_50298887_ENST00000354293_length(amino acids)=745AA_BP=25
MLSLELCHSGLCKFPKVGGKMTMSKIVSSASTDLQDYTYYFVPAPWLSVKLLRLLQCYPPPEDAAVKGRLVECLETVLNKAQEPPKSKKV
QHSNAKNAILFETISLIIHYDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIDTVINALKTERDVSVRQRAA
DLLYAMCDRSNAKQIVSEMLRYLETADYAIREEIVLKVAILAEKYAVDYSWYVDTILNLIRIAGDYVSEEVWYRVLQIVTNRDDVQGYAA
KTVFEALQAPACHENMVKVGGYILGEFGNLIAGDPRSSPPVQFSLLHSKFHLCSVATRALLLSTYIKFINLFPETKATIQGVLRAGSQLR
NADVELQQRAVEYLTLSSVASTDVLATVLEEMPPFPERESSILAKLKRKKGPGAGSALDDGRRDPSSNDINGGMEPTPSTVSTPSPSADL
LGLRAAPPPAAPPASAGAGNLLVDVFDGPAAQPSLGPTPEEAFLSPGPEDIGPPIPEADELLNKFVCKNNGVLFENQLLQIGVKSEFRQN
LGRMYLFYGNKTSVQFQNFSPTVVHPGDLQTQLAVQTKRVAAQVDGGAQVQQVLNIECLRDFLTPPLLSVRFRYGGAPQALTLKLPVTIN
KFFQPTEMAAQDFFQRWKQLSLPQQEAQKIFKANHPMDAEVTKAKLLGFGSALLDNVDPNPENFVGAGIIQTKALQVGCLLRLEPNAQAQ

--------------------------------------------------------------
>101644_101644_3_ZNF223-AP2A1_ZNF223_chr19_44559344_ENST00000591793_AP2A1_chr19_50298887_ENST00000354293_length(transcript)=2945nt_BP=428nt
TTTACCACAGTAGTTTGAGTCATTTCCACATCTTGCGAGTCCTTCCGAACGAGTCTCCTTTCCTTGGGGCTCGCAACCACCCAATGATCG
ATTCAGGAGAAAAGAAGCCTGGGCGGAGAGCAGAGGAGGCAGTGACCTTCAAGGATGTGGCTGTGATCTTCACTGAGGAGGAGCTGGGGC
TGCTGGACCCTGCCCAGAGGAAGCTGTACCGAGATGTGATGCTTGAGAACTTCAGGAACCTGCTCTCAGTGGGGCATCAACCATTCCATG
GAGATACTTTCCACTTCCTAAGGGAAGAAAAGTTTTGGGTGATGGGGACAACAAGCCAAAGAGAAGGGAATTTGGGCACAATTCTGCTTT
CCCTGGAACTGTGTCATTCAGGACTCTGCAAATTCCCTAAAGTAGGAGGAAAAATGACCATGTCCAAGATCGTCTCCTCTGCCTCCACCG
ACCTCCAGGACTACACCTACTACTTCGTCCCAGCACCCTGGCTCTCGGTGAAGCTCCTGCGGCTGCTGCAGTGCTACCCGCCTCCAGAGG
ATGCGGCTGTGAAGGGGCGGCTGGTGGAATGTCTGGAGACTGTGCTCAACAAGGCCCAGGAGCCCCCCAAATCCAAGAAGGTGCAGCATT
CCAACGCCAAGAACGCCATCCTCTTCGAGACCATCAGCCTCATCATCCACTATGACAGTGAGCCCAACCTCCTGGTTCGGGCCTGCAACC
AGCTGGGCCAGTTCCTGCAGCACCGGGAGACCAACCTGCGCTACCTGGCCCTGGAGAGCATGTGCACGCTGGCCAGCTCCGAGTTCTCCC
ATGAAGCCGTCAAGACGCACATTGACACCGTCATCAATGCCCTCAAGACGGAGCGGGACGTCAGCGTGCGGCAGCGGGCGGCTGACCTCC
TCTACGCCATGTGTGACCGGAGCAATGCCAAGCAGATCGTGTCGGAGATGCTGCGGTACCTGGAGACGGCAGACTACGCCATCCGCGAGG
AGATCGTCCTGAAGGTGGCCATCCTGGCCGAGAAGTACGCCGTGGACTACAGCTGGTACGTGGACACCATCCTCAACCTCATCCGCATTG
CGGGCGACTACGTGAGTGAGGAGGTGTGGTACCGTGTGCTACAGATCGTCACCAACCGTGATGACGTCCAGGGCTATGCCGCCAAGACCG
TCTTTGAGGCGCTCCAGGCCCCTGCCTGTCACGAGAACATGGTGAAGGTTGGCGGCTACATCCTTGGGGAGTTTGGGAACCTGATTGCTG
GGGACCCCCGCTCCAGCCCCCCAGTGCAGTTCTCCCTGCTCCACTCCAAGTTCCATCTGTGCAGCGTGGCCACGCGGGCGCTGCTGCTGT
CCACCTACATCAAGTTCATCAACCTCTTCCCCGAGACCAAGGCCACCATCCAGGGCGTCCTGCGGGCCGGCTCCCAGCTGCGCAATGCTG
ACGTGGAGCTGCAGCAGCGAGCCGTGGAGTACCTCACCCTCAGCTCAGTGGCCAGCACCGACGTCCTGGCCACGGTGCTGGAGGAGATGC
CGCCCTTCCCCGAGCGCGAGTCGTCCATCCTGGCCAAGCTGAAACGCAAGAAGGGGCCAGGGGCCGGCAGCGCCCTGGACGATGGCCGGA
GGGACCCCAGCAGCAACGACATCAACGGGGGCATGGAGCCCACCCCCAGCACTGTGTCGACGCCCTCGCCCTCCGCCGACCTCCTGGGGC
TGCGGGCAGCCCCTCCCCCGGCAGCACCCCCGGCTTCTGCAGGAGCAGGGAACCTTCTGGTGGACGTCTTCGATGGCCCGGCCGCCCAGC
CCAGCCTGGGGCCCACCCCCGAGGAGGCCTTCCTCAGCCCAGGTCCTGAGGACATCGGCCCTCCCATTCCGGAAGCCGATGAGTTGCTGA
ATAAGTTTGTGTGTAAGAACAACGGGGTCCTGTTCGAGAACCAGCTGCTGCAGATCGGAGTCAAGTCAGAGTTCCGACAGAACCTGGGCC
GCATGTATCTCTTCTATGGCAACAAGACCTCGGTGCAGTTCCAGAATTTCTCACCCACTGTGGTTCACCCGGGAGACCTCCAGACTCAGC
TGGCTGTGCAGACCAAGCGCGTGGCGGCGCAGGTGGACGGCGGCGCGCAGGTGCAGCAGGTGCTCAATATCGAGTGCCTGCGGGACTTCC
TGACGCCCCCGCTGCTGTCCGTGCGCTTCCGGTACGGTGGCGCCCCCCAGGCCCTCACCCTGAAGCTCCCAGTGACCATCAACAAGTTCT
TCCAGCCCACCGAGATGGCGGCCCAGGATTTCTTCCAGCGCTGGAAGCAGCTGAGCCTCCCTCAACAGGAGGCGCAGAAAATCTTCAAAG
CCAACCACCCCATGGACGCAGAAGTTACTAAGGCCAAGCTTCTGGGGTTTGGCTCTGCTCTCCTGGACAATGTGGACCCCAACCCTGAGA
ACTTCGTGGGGGCGGGGATCATCCAGACTAAAGCCCTGCAGGTGGGCTGTCTGCTTCGGCTGGAGCCCAATGCCCAGGCCCAGATGTACC
GGCTGACCCTGCGCACCAGCAAGGAGCCCGTCTCCCGTCACCTGTGTGAGCTGCTGGCACAGCAGTTCTGAGCCCTGGACTCTGCCCCGG
GGGATGTGGCCGGCACTGGGCAGCCCCTTGGACTGAGGCAGTTTTGGTGGATGGGGGACCTCCACTGGTGACAGAGAAGACACCAGGGTT
TGGGGGATGCCTGGGACTTTCCTCCGGCCTTTTGTATTTTTATTTTTGTTCATCTGCTGCTGTTTACATTCTGGGGGGTTAGGGGGAGTC
CCCCTCCCTCCCTTTCCCCCCCAAGCACAGAGGGGAGAGGGGCCAGGGAAGTGGATGTCTCCTCCCCTCCCACCCCACCCTGTTGTAGCC

>101644_101644_3_ZNF223-AP2A1_ZNF223_chr19_44559344_ENST00000591793_AP2A1_chr19_50298887_ENST00000354293_length(amino acids)=858AA_BP=138
MSHFHILRVLPNESPFLGARNHPMIDSGEKKPGRRAEEAVTFKDVAVIFTEEELGLLDPAQRKLYRDVMLENFRNLLSVGHQPFHGDTFH
FLREEKFWVMGTTSQREGNLGTILLSLELCHSGLCKFPKVGGKMTMSKIVSSASTDLQDYTYYFVPAPWLSVKLLRLLQCYPPPEDAAVK
GRLVECLETVLNKAQEPPKSKKVQHSNAKNAILFETISLIIHYDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEFSHEAVK
THIDTVINALKTERDVSVRQRAADLLYAMCDRSNAKQIVSEMLRYLETADYAIREEIVLKVAILAEKYAVDYSWYVDTILNLIRIAGDYV
SEEVWYRVLQIVTNRDDVQGYAAKTVFEALQAPACHENMVKVGGYILGEFGNLIAGDPRSSPPVQFSLLHSKFHLCSVATRALLLSTYIK
FINLFPETKATIQGVLRAGSQLRNADVELQQRAVEYLTLSSVASTDVLATVLEEMPPFPERESSILAKLKRKKGPGAGSALDDGRRDPSS
NDINGGMEPTPSTVSTPSPSADLLGLRAAPPPAAPPASAGAGNLLVDVFDGPAAQPSLGPTPEEAFLSPGPEDIGPPIPEADELLNKFVC
KNNGVLFENQLLQIGVKSEFRQNLGRMYLFYGNKTSVQFQNFSPTVVHPGDLQTQLAVQTKRVAAQVDGGAQVQQVLNIECLRDFLTPPL
LSVRFRYGGAPQALTLKLPVTINKFFQPTEMAAQDFFQRWKQLSLPQQEAQKIFKANHPMDAEVTKAKLLGFGSALLDNVDPNPENFVGA

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Fusion Gene PPI Analysis for ZNF223-AP2A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF223-AP2A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF223-AP2A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource