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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ZNF226-EIF3K (FusionGDB2 ID:101649)

Fusion Gene Summary for ZNF226-EIF3K

Fusion gene summary

Fusion gene information	Fusion gene name: ZNF226-EIF3K
	Fusion gene ID: 101649
		Hgene	Tgene
	Gene symbol	ZNF226	EIF3K
	Gene ID	7769	27335
	Gene name	zinc finger protein 226	eukaryotic translation initiation factor 3 subunit K
	Synonyms	-	ARG134\|EIF3-p28\|EIF3S12\|HSPC029\|M9\|MSTP001\|PLAC-24\|PLAC24\|PRO1474\|PTD001
	Cytomap	19q13.31	19q13.2
	Type of gene	protein-coding	protein-coding
	Description	zinc finger protein 226Kruppel-associated box protein	eukaryotic translation initiation factor 3 subunit KeIF-3 p28eukaryotic translation initiation factor 3, subunit 12muscle specificmuscle-specific gene M9 protein
	Modification date	20200313	20200322
	UniProtAcc	.	Q9UBQ5
	Ensembl transtripts involved in fusion gene	ENST00000300823, ENST00000337433, ENST00000413984, ENST00000454662, ENST00000588742, ENST00000588795, ENST00000588883, ENST00000589160, ENST00000590089,	ENST00000593062, ENST00000248342, ENST00000593149, ENST00000538434, ENST00000545173, ENST00000588934, ENST00000592558,
Fusion gene scores	* DoF score	4 X 2 X 4=32	9 X 11 X 9=891
	# samples	4	14
	** MAII score	log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(14/891*10)=-2.66999860457696 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ZNF226 [Title/Abstract] AND EIF3K [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ZNF226(44669960)-EIF3K(39110977), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	EIF3K	GO:0006413	translational initiation	17581632

Fusion gene breakpoints across ZNF226 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across EIF3K (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-DX-A8BL-01A	ZNF226	chr19	44669960	-	EIF3K	chr19	39110977	+
ChimerDB4	SARC	TCGA-DX-A8BL-01A	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+

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Fusion Gene ORF analysis for ZNF226-EIF3K

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3UTR	ENST00000300823	ENST00000593062	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-3UTR	ENST00000337433	ENST00000593062	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-3UTR	ENST00000413984	ENST00000593062	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-3UTR	ENST00000454662	ENST00000593062	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-3UTR	ENST00000588742	ENST00000593062	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-3UTR	ENST00000588795	ENST00000593062	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-3UTR	ENST00000588883	ENST00000593062	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-3UTR	ENST00000589160	ENST00000593062	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-3UTR	ENST00000590089	ENST00000593062	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-5UTR	ENST00000300823	ENST00000248342	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-5UTR	ENST00000300823	ENST00000593149	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-5UTR	ENST00000337433	ENST00000248342	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-5UTR	ENST00000337433	ENST00000593149	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-5UTR	ENST00000413984	ENST00000248342	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-5UTR	ENST00000413984	ENST00000593149	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-5UTR	ENST00000454662	ENST00000248342	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-5UTR	ENST00000454662	ENST00000593149	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-5UTR	ENST00000588742	ENST00000248342	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-5UTR	ENST00000588742	ENST00000593149	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-5UTR	ENST00000588795	ENST00000248342	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-5UTR	ENST00000588795	ENST00000593149	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-5UTR	ENST00000588883	ENST00000248342	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-5UTR	ENST00000588883	ENST00000593149	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-5UTR	ENST00000589160	ENST00000248342	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-5UTR	ENST00000589160	ENST00000593149	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-5UTR	ENST00000590089	ENST00000248342	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-5UTR	ENST00000590089	ENST00000593149	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-intron	ENST00000300823	ENST00000538434	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-intron	ENST00000300823	ENST00000545173	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-intron	ENST00000300823	ENST00000588934	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-intron	ENST00000300823	ENST00000592558	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-intron	ENST00000337433	ENST00000538434	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-intron	ENST00000337433	ENST00000545173	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-intron	ENST00000337433	ENST00000588934	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-intron	ENST00000337433	ENST00000592558	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-intron	ENST00000413984	ENST00000538434	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-intron	ENST00000413984	ENST00000545173	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-intron	ENST00000413984	ENST00000588934	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-intron	ENST00000413984	ENST00000592558	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-intron	ENST00000454662	ENST00000538434	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-intron	ENST00000454662	ENST00000545173	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-intron	ENST00000454662	ENST00000588934	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-intron	ENST00000454662	ENST00000592558	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-intron	ENST00000588742	ENST00000538434	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-intron	ENST00000588742	ENST00000545173	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-intron	ENST00000588742	ENST00000588934	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-intron	ENST00000588742	ENST00000592558	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-intron	ENST00000588795	ENST00000538434	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-intron	ENST00000588795	ENST00000545173	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-intron	ENST00000588795	ENST00000588934	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-intron	ENST00000588795	ENST00000592558	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-intron	ENST00000588883	ENST00000538434	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-intron	ENST00000588883	ENST00000545173	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-intron	ENST00000588883	ENST00000588934	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-intron	ENST00000588883	ENST00000592558	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-intron	ENST00000589160	ENST00000538434	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-intron	ENST00000589160	ENST00000545173	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-intron	ENST00000589160	ENST00000588934	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-intron	ENST00000589160	ENST00000592558	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-intron	ENST00000590089	ENST00000538434	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-intron	ENST00000590089	ENST00000545173	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-intron	ENST00000590089	ENST00000588934	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+
5UTR-intron	ENST00000590089	ENST00000592558	ZNF226	chr19	44669960	+	EIF3K	chr19	39110977	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for ZNF226-EIF3K

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ZNF226	chr19	44669960	+	EIF3K	chr19	39110976	+	2.11E-06	0.99999785
ZNF226	chr19	44669960	+	EIF3K	chr19	39110976	+	2.11E-06	0.99999785

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF226-EIF3K

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:44669960/:39110977)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	EIF3K Q9UBQ5
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255\|HAMAP-Rule:MF_03010, ECO:0000269\|PubMed:17581632, ECO:0000269\|PubMed:25849773, ECO:0000269\|PubMed:27462815}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for ZNF226-EIF3K

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ZNF226-EIF3K

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ZNF226-EIF3K

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ZNF226-EIF3K

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source