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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:BRCC3-TRAC (FusionGDB2 ID:10165)

Fusion Gene Summary for BRCC3-TRAC

Fusion gene summary

Fusion gene information	Fusion gene name: BRCC3-TRAC
	Fusion gene ID: 10165
		Hgene	Tgene
	Gene symbol	BRCC3	TRAC
	Gene ID	79184	9612
	Gene name	BRCA1/BRCA2-containing complex subunit 3	nuclear receptor corepressor 2
	Synonyms	BRCC36\|C6.1A\|CXorf53	CTG26\|N-CoR2\|SMAP270\|SMRT\|SMRTE\|SMRTE-tau\|TNRC14\|TRAC\|TRAC-1\|TRAC1
	Cytomap	Xq28	12q24.31
	Type of gene	protein-coding	protein-coding
	Description	lys-63-specific deubiquitinase BRCC36BRCA1-A complex subunit BRCC36BRCA1/BRCA2-containing complex subunit 36BRISC complex subunit BRCC36	nuclear receptor corepressor 2CTG repeat protein 26T3 receptor-associating factorsilencing mediator for retinoid and thyroid hormone receptorsthyroid-, retinoic-acid-receptor-associated corepressor
	Modification date	20200313	20200313
	UniProtAcc	P46736	TAAR6
	Ensembl transtripts involved in fusion gene	ENST00000330045, ENST00000340647, ENST00000369459, ENST00000369462, ENST00000399042,	ENST00000478163,
Fusion gene scores	* DoF score	5 X 4 X 4=80	8 X 3 X 3=72
	# samples	6	8
	** MAII score	log2(6/80*10)=-0.415037499278844 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/72*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: BRCC3 [Title/Abstract] AND TRAC [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	BRCC3(154345029)-TRAC(23016444), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	BRCC3	GO:0010165	response to X-ray	14636569
Hgene	BRCC3	GO:0070536	protein K63-linked deubiquitination	17525341\|19214193
Hgene	BRCC3	GO:0070537	histone H2A K63-linked deubiquitination	19202061

Fusion gene breakpoints across BRCC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TRAC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	S72931	BRCC3	chrX	154345029	+	TRAC	chr14	23016444	+
ChiTaRS5.0	N/A	S72942	BRCC3	chrX	154345029	+	TRAC	chr14	23016444	+

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Fusion Gene ORF analysis for BRCC3-TRAC

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000330045	ENST00000478163	BRCC3	chrX	154345029	+	TRAC	chr14	23016444	+
In-frame	ENST00000340647	ENST00000478163	BRCC3	chrX	154345029	+	TRAC	chr14	23016444	+
In-frame	ENST00000369459	ENST00000478163	BRCC3	chrX	154345029	+	TRAC	chr14	23016444	+
In-frame	ENST00000369462	ENST00000478163	BRCC3	chrX	154345029	+	TRAC	chr14	23016444	+
In-frame	ENST00000399042	ENST00000478163	BRCC3	chrX	154345029	+	TRAC	chr14	23016444	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000340647

BRCC3

chrX

154345029

ENST00000478163

TRAC

chr14

23016444

1809

835

1259

409

ENST00000330045

BRCC3

chrX

154345029

ENST00000478163

TRAC

chr14

23016444

1795

821

1245

408

ENST00000369459

BRCC3

chrX

154345029

ENST00000478163

TRAC

chr14

23016444

1595

621

1045

338

ENST00000369462

BRCC3

chrX

154345029

ENST00000478163

TRAC

chr14

23016444

1798

824

1248

407

ENST00000399042

BRCC3

chrX

154345029

ENST00000478163

TRAC

chr14

23016444

1773

799

1223

407

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000340647	ENST00000478163	BRCC3	chrX	154345029	+	TRAC	chr14	23016444	+	0.001699267	0.99830073
ENST00000330045	ENST00000478163	BRCC3	chrX	154345029	+	TRAC	chr14	23016444	+	0.001919313	0.99808073
ENST00000369459	ENST00000478163	BRCC3	chrX	154345029	+	TRAC	chr14	23016444	+	0.000714721	0.9992853
ENST00000369462	ENST00000478163	BRCC3	chrX	154345029	+	TRAC	chr14	23016444	+	0.000932921	0.9990671
ENST00000399042	ENST00000478163	BRCC3	chrX	154345029	+	TRAC	chr14	23016444	+	0.001043097	0.9989569

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Fusion Genomic Features for BRCC3-TRAC

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
BRCC3	chrX	154345029	+	TRAC	chr14	23016446	+	0.7978811	0.2021189
BRCC3	chrX	154345029	+	TRAC	chr14	23016446	+	0.7978811	0.2021189

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for BRCC3-TRAC

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:154345029/chr14:23016444)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
BRCC3 P46736	TRAC TAAR6
FUNCTION: Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:19214193, PubMed:20656690, PubMed:24075985, PubMed:26344097). Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs) (PubMed:20656690). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:20656690, PubMed:24075985, PubMed:26344097, PubMed:26195665). Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex (PubMed:19214193). The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). {ECO:0000269\|PubMed:14636569, ECO:0000269\|PubMed:16707425, ECO:0000269\|PubMed:17525341, ECO:0000269\|PubMed:19202061, ECO:0000269\|PubMed:19214193, ECO:0000269\|PubMed:19261746, ECO:0000269\|PubMed:19261748, ECO:0000269\|PubMed:19261749, ECO:0000269\|PubMed:20656690, ECO:0000269\|PubMed:24075985, ECO:0000269\|PubMed:26195665, ECO:0000269\|PubMed:26344097}.	345

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

BRCC3

chrX:154345029

chr14:23016444

ENST00000330045

12_179

241

720.3333333333334

Domain

MPN

Hgene

BRCC3

chrX:154345029

chr14:23016444

ENST00000340647

12_179

242

248.0

Domain

MPN

Hgene

BRCC3

chrX:154345029

chr14:23016444

ENST00000369459

12_179

197

814.0

Domain

MPN

Hgene

BRCC3

chrX:154345029

chr14:23016444

ENST00000369462

12_179

266

885.0

Domain

MPN

Hgene

BRCC3

chrX:154345029

chr14:23016444

ENST00000330045

122_135

241

720.3333333333334

Motif

JAMM motif

Hgene

BRCC3

chrX:154345029

chr14:23016444

ENST00000340647

122_135

242

248.0

Motif

JAMM motif

Hgene

BRCC3

chrX:154345029

chr14:23016444

ENST00000369459

122_135

197

814.0

Motif

JAMM motif

Hgene

BRCC3

chrX:154345029

chr14:23016444

ENST00000369462

122_135

266

885.0

Motif

JAMM motif

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for BRCC3-TRAC

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>10165_10165_1_BRCC3-TRAC_BRCC3_chrX_154345029_ENST00000330045_TRAC_chr14_23016444_ENST00000478163_length(transcript)=1795nt_BP=821nt
GAGCGCACAGCGCTGGGCGCTGGGGAGGCTGCGCCGCAGCACCCGGTTGGTCAGGACCAAGTGGGCCCGAGGCGGACGTGAGAAGGGTCG
GGCCAAGATGGCGGTGCAGGTGGTGCAGGCGGTGCAGGCGGTTCATCTCGAGTCTGACGCTTTCCTCGTTTGTCTCAACCACGCTCTGAG
CACAGAGAAGGAGGAAGTAATGGGGCTGTGCATAGGGGAGTTGAACGATGATACAAGGAGTGACTCCAAATTTGCATATACTGGAACTGA
AATGCGCACAGTTGCTGAAAAGGTTGATGCCGTCAGAATTGTTCACATTCATTCTGTCATCATCTTACGACGTTCTGATAAGAGGAAGGA
CCGAGTAGAAATTTCTCCAGAGCAGCTGTCTGCAGCTTCAACAGAGGCAGAGAGGTTGGCTGAACTGACAGGCCGCCCCATGAGAGTTGT
GGGCTGGTATCATTCCCATCCTCATATAACTGTTTGGCCTTCACATGTTGATGTTCGCACACAAGCCATGTACCAGATGATGGATCAAGG
CTTTGTAGGACTTATTTTTTCCTGTTTCATAGAAGATAAGAACACAAAGACTGGCCGGGTACTCTACACTTGCTTCCAATCCATACAGGC
CCAAAAGAGTTCAGAGTATGAGAGAATCGAAATCCCAATCCATATTGTACCTCATGTCACTATCGGGAAAGTGTGCCTTGAATCAGCAGT
AGAGCTGCCCAAGATCCTGTGCCAGGAGGAGCAGGATGCGTATAGGAGGATCCACAGCCTTACACATCTGGACTCAGTAACCAAGATCCA
TAATGGCTCAGATATCCAGAACCCTGACCCTGCCGTGTACCAGCTGAGAGACTCTAAATCCAGTGACAAGTCTGTCTGCCTATTCACCGA
TTTTGATTCTCAAACAAATGTGTCACAAAGTAAGGATTCTGATGTGTATATCACAGACAAAACTGTGCTAGACATGAGGTCTATGGACTT
CAAGAGCAACAGTGCTGTGGCCTGGAGCAACAAATCTGACTTTGCATGTGCAAACGCCTTCAACAACAGCATTATTCCAGAAGACACCTT
CTTCCCCAGCCCAGAAAGTTCCTGTGATGTCAAGCTGGTCGAGAAAAGCTTTGAAACAGATACGAACCTAAACTTTCAAAACCTGTCAGT
GATTGGGTTCCGAATCCTCCTCCTGAAAGTGGCCGGGTTTAATCTGCTCATGACGCTGCGGCTGTGGTCCAGCTGAGATCTGCAAGATTG
TAAGACAGCCTGTGCTCCCTCGCTCCTTCCTCTGCATTGCCCCTCTTCTCCCTCTCCAAACAGAGGGAACTCTCCTACCCCCAAGGAGGT
GAAAGCTGCTACCACCTCTGTGCCCCCCCGGCAATGCACCAACTGGATCCTACCCGAATTTATGATTAAGATTGCTGAAGAGCTGCCAAA
CACTGCTGCCACCCCCTCTGTTCCCTTATTGCTGCTTGTCACTGCCTGACATTCACGGCAGAGGCAAGGCTGCTGCAGCTCCGCTGGCTG
TGCACATTCCCTCCTGCTCCCCAGAGACTGCCTCCGCCATCCCACAGATGATGGATCTTCAGTGGGTTCTCTTGGGCTCTAGGTCCCGGA
GAATGTTGTGAGGGGTTTATTTTTTTTTAATAGTGTTCATAAAGAAAGACATAGTATTCTTCTTCTCAAGACGTGGGGGGAAATTATCTC

>10165_10165_1_BRCC3-TRAC_BRCC3_chrX_154345029_ENST00000330045_TRAC_chr14_23016444_ENST00000478163_length(amino acids)=408AA_BP=267
MGRLRRSTRLVRTKWARGGREKGRAKMAVQVVQAVQAVHLESDAFLVCLNHALSTEKEEVMGLCIGELNDDTRSDSKFAYTGTEMRTVAE
KVDAVRIVHIHSVIILRRSDKRKDRVEISPEQLSAASTEAERLAELTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIF
SCFIEDKNTKTGRVLYTCFQSIQAQKSSEYERIEIPIHIVPHVTIGKVCLESAVELPKILCQEEQDAYRRIHSLTHLDSVTKIHNGSDIQ
NPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFPSPES

--------------------------------------------------------------
>10165_10165_2_BRCC3-TRAC_BRCC3_chrX_154345029_ENST00000340647_TRAC_chr14_23016444_ENST00000478163_length(transcript)=1809nt_BP=835nt
AGGCCTGGGCGGAGCGCACAGCGCTGGGCGCTGGGGAGGCTGCGCCGCAGCACCCGGTTGGTCAGGACCAAGTGGGCCCGAGGCGGACGT
GAGAAGGGTCGGGCCAAGATGGCGGTGCAGGTGGTGCAGGCGGTGCAGGCGGTTCATCTCGAGTCTGACGCTTTCCTCGTTTGTCTCAAC
CACGCTCTGAGCACAGAGAAGGAGGAAGTAATGGGGCTGTGCATAGGGGAGTTGAACGATGATACAAGTAGGAGTGACTCCAAATTTGCA
TATACTGGAACTGAAATGCGCACAGTTGCTGAAAAGGTTGATGCCGTCAGAATTGTTCACATTCATTCTGTCATCATCTTACGACGTTCT
GATAAGAGGAAGGACCGAGTAGAAATTTCTCCAGAGCAGCTGTCTGCAGCTTCAACAGAGGCAGAGAGGTTGGCTGAACTGACAGGCCGC
CCCATGAGAGTTGTGGGCTGGTATCATTCCCATCCTCATATAACTGTTTGGCCTTCACATGTTGATGTTCGCACACAAGCCATGTACCAG
ATGATGGATCAAGGCTTTGTAGGACTTATTTTTTCCTGTTTCATAGAAGATAAGAACACAAAGACTGGCCGGGTACTCTACACTTGCTTC
CAATCCATACAGGCCCAAAAGAGTTCAGAGTATGAGAGAATCGAAATCCCAATCCATATTGTACCTCATGTCACTATCGGGAAAGTGTGC
CTTGAATCAGCAGTAGAGCTGCCCAAGATCCTGTGCCAGGAGGAGCAGGATGCGTATAGGAGGATCCACAGCCTTACACATCTGGACTCA
GTAACCAAGATCCATAATGGCTCAGATATCCAGAACCCTGACCCTGCCGTGTACCAGCTGAGAGACTCTAAATCCAGTGACAAGTCTGTC
TGCCTATTCACCGATTTTGATTCTCAAACAAATGTGTCACAAAGTAAGGATTCTGATGTGTATATCACAGACAAAACTGTGCTAGACATG
AGGTCTATGGACTTCAAGAGCAACAGTGCTGTGGCCTGGAGCAACAAATCTGACTTTGCATGTGCAAACGCCTTCAACAACAGCATTATT
CCAGAAGACACCTTCTTCCCCAGCCCAGAAAGTTCCTGTGATGTCAAGCTGGTCGAGAAAAGCTTTGAAACAGATACGAACCTAAACTTT
CAAAACCTGTCAGTGATTGGGTTCCGAATCCTCCTCCTGAAAGTGGCCGGGTTTAATCTGCTCATGACGCTGCGGCTGTGGTCCAGCTGA
GATCTGCAAGATTGTAAGACAGCCTGTGCTCCCTCGCTCCTTCCTCTGCATTGCCCCTCTTCTCCCTCTCCAAACAGAGGGAACTCTCCT
ACCCCCAAGGAGGTGAAAGCTGCTACCACCTCTGTGCCCCCCCGGCAATGCACCAACTGGATCCTACCCGAATTTATGATTAAGATTGCT
GAAGAGCTGCCAAACACTGCTGCCACCCCCTCTGTTCCCTTATTGCTGCTTGTCACTGCCTGACATTCACGGCAGAGGCAAGGCTGCTGC
AGCTCCGCTGGCTGTGCACATTCCCTCCTGCTCCCCAGAGACTGCCTCCGCCATCCCACAGATGATGGATCTTCAGTGGGTTCTCTTGGG
CTCTAGGTCCCGGAGAATGTTGTGAGGGGTTTATTTTTTTTTAATAGTGTTCATAAAGAAAGACATAGTATTCTTCTTCTCAAGACGTGG
GGGGAAATTATCTCATTATCGAGGCCCTGCTATGCTGTGTGTCTGGGCGTGTTGTATGTCCTGCTGCCGATGCCTTCATTAAAATGATTT

>10165_10165_2_BRCC3-TRAC_BRCC3_chrX_154345029_ENST00000340647_TRAC_chr14_23016444_ENST00000478163_length(amino acids)=409AA_BP=268
MGRLRRSTRLVRTKWARGGREKGRAKMAVQVVQAVQAVHLESDAFLVCLNHALSTEKEEVMGLCIGELNDDTSRSDSKFAYTGTEMRTVA
EKVDAVRIVHIHSVIILRRSDKRKDRVEISPEQLSAASTEAERLAELTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLI
FSCFIEDKNTKTGRVLYTCFQSIQAQKSSEYERIEIPIHIVPHVTIGKVCLESAVELPKILCQEEQDAYRRIHSLTHLDSVTKIHNGSDI
QNPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFPSPE

--------------------------------------------------------------
>10165_10165_3_BRCC3-TRAC_BRCC3_chrX_154345029_ENST00000369459_TRAC_chr14_23016444_ENST00000478163_length(transcript)=1595nt_BP=621nt
GAGGCGGACGTGAGAAGGGTCGGGCCAAGATGGCGGTGCAGGTGGTGCAGGCGGTGCAGGCGGTTCATCTCGAGTCTGACGCTTTCCTCG
TTTGTCTCAACCACGCTCTGAGCACAGAGAAGGAGGAAGTAATGGGGCTGTGCATAGGGGAGTTGAACGATGATACAAGGAGTGACTCCA
AATTTGCATATACTGGAACTGAAATGCGCACAGTTGCTGAAAAGGTTGATGCCGTCAGAATTGTTCACATTCATTCTGTCATCATCTTAC
GACGTTCTGATAAGAGGAAGGACCGAGTAGAAATTTCTCCAGAGCAGCTGTCTGCAGCTTCAACAGAGGCAGAGAGGTTGGCTGAACTGA
CAGGCCGCCCCATGAGAGTTGTGGGCTGGTATCATTCCCATCCTCATATAACTGTTTGGCCTTCACATGTTGATGTTCGCACACAAGCCA
TGTACCAGATGATGGATCAAGGCTTTGTAGGACTTATTTTTTCCTGTTTCATAGAAGATAAGAACACAAAGACTGGCCGGGTACTCTACA
CTTGCTTCCAATCCATACAGGCCCAAAAGAGTTCAGACCTTACACATCTGGACTCAGTAACCAAGATCCATAATGGCTCAGATATCCAGA
ACCCTGACCCTGCCGTGTACCAGCTGAGAGACTCTAAATCCAGTGACAAGTCTGTCTGCCTATTCACCGATTTTGATTCTCAAACAAATG
TGTCACAAAGTAAGGATTCTGATGTGTATATCACAGACAAAACTGTGCTAGACATGAGGTCTATGGACTTCAAGAGCAACAGTGCTGTGG
CCTGGAGCAACAAATCTGACTTTGCATGTGCAAACGCCTTCAACAACAGCATTATTCCAGAAGACACCTTCTTCCCCAGCCCAGAAAGTT
CCTGTGATGTCAAGCTGGTCGAGAAAAGCTTTGAAACAGATACGAACCTAAACTTTCAAAACCTGTCAGTGATTGGGTTCCGAATCCTCC
TCCTGAAAGTGGCCGGGTTTAATCTGCTCATGACGCTGCGGCTGTGGTCCAGCTGAGATCTGCAAGATTGTAAGACAGCCTGTGCTCCCT
CGCTCCTTCCTCTGCATTGCCCCTCTTCTCCCTCTCCAAACAGAGGGAACTCTCCTACCCCCAAGGAGGTGAAAGCTGCTACCACCTCTG
TGCCCCCCCGGCAATGCACCAACTGGATCCTACCCGAATTTATGATTAAGATTGCTGAAGAGCTGCCAAACACTGCTGCCACCCCCTCTG
TTCCCTTATTGCTGCTTGTCACTGCCTGACATTCACGGCAGAGGCAAGGCTGCTGCAGCTCCGCTGGCTGTGCACATTCCCTCCTGCTCC
CCAGAGACTGCCTCCGCCATCCCACAGATGATGGATCTTCAGTGGGTTCTCTTGGGCTCTAGGTCCCGGAGAATGTTGTGAGGGGTTTAT
TTTTTTTTAATAGTGTTCATAAAGAAAGACATAGTATTCTTCTTCTCAAGACGTGGGGGGAAATTATCTCATTATCGAGGCCCTGCTATG

>10165_10165_3_BRCC3-TRAC_BRCC3_chrX_154345029_ENST00000369459_TRAC_chr14_23016444_ENST00000478163_length(amino acids)=338AA_BP=197
MAVQVVQAVQAVHLESDAFLVCLNHALSTEKEEVMGLCIGELNDDTRSDSKFAYTGTEMRTVAEKVDAVRIVHIHSVIILRRSDKRKDRV
EISPEQLSAASTEAERLAELTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIFSCFIEDKNTKTGRVLYTCFQSIQAQK
SSDLTHLDSVTKIHNGSDIQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSMDFKSNSAVAWSNKSDFAC

--------------------------------------------------------------
>10165_10165_4_BRCC3-TRAC_BRCC3_chrX_154345029_ENST00000369462_TRAC_chr14_23016444_ENST00000478163_length(transcript)=1798nt_BP=824nt
CGGACGTGAGAAGGGTCGGGCCAAGATGGCGGTGCAGGTGGTGCAGGCGGTGCAGGCGGTTCATCTCGAGTCTGACGCTTTCCTCGTTTG
TCTCAACCACGCTCTGAGCACAGAGAAGGAGGAAGTAATGGGGCTGTGCATAGGGGAGTTGAACGATGATACAAGGAGTGACTCCAAATT
TGCATATACTGGAACTGAAATGCGCACAGTTGCTGAAAAGGTTGATGCCGTCAGAATTGTTCACATTCATTCTGTCATCATCTTACGACG
TTCTGATAAGAGGAAGGACCGAGTAGAAATTTCTCCAGAGCAGCTGTCTGCAGCTTCAACAGAGGCAGAGAGGTTGGCTGAACTGACAGG
CCGCCCCATGAGAGTTGTGGGCTGGTATCATTCCCATCCTCATATAACTGTTTGGCCTTCACATGTTGATGTTCGCACACAAGCCATGTA
CCAGATGATGGATCAAGGCTTTGTAGGACTTATTTTTTCCTGTTTCATAGAAGATAAGAACACAAAGACTGGCCGGGTACTCTACACTTG
CTTCCAATCCATACAGGCCCAAAAGAGTTCAGAGTCCCTTCATGGTCCACGAGACTTCTGGAGCTCCAGCCAGCACATCTCCATTGAGGG
CCAGAAGGAAGAGGAAAGGTATGAGAGAATCGAAATCCCAATCCATATTGTACCTCATGTCACTATCGGGAAAGTGTGCCTTGAATCAGC
AGTAGAGCTGCCCAAGATCCTGTGCCAGGAGGAGCAGGATGCGTATAGGAGGATCCACAGCCTTACACATCTGGACTCAGTAACCAAGAT
CCATAATGGCTCAGATATCCAGAACCCTGACCCTGCCGTGTACCAGCTGAGAGACTCTAAATCCAGTGACAAGTCTGTCTGCCTATTCAC
CGATTTTGATTCTCAAACAAATGTGTCACAAAGTAAGGATTCTGATGTGTATATCACAGACAAAACTGTGCTAGACATGAGGTCTATGGA
CTTCAAGAGCAACAGTGCTGTGGCCTGGAGCAACAAATCTGACTTTGCATGTGCAAACGCCTTCAACAACAGCATTATTCCAGAAGACAC
CTTCTTCCCCAGCCCAGAAAGTTCCTGTGATGTCAAGCTGGTCGAGAAAAGCTTTGAAACAGATACGAACCTAAACTTTCAAAACCTGTC
AGTGATTGGGTTCCGAATCCTCCTCCTGAAAGTGGCCGGGTTTAATCTGCTCATGACGCTGCGGCTGTGGTCCAGCTGAGATCTGCAAGA
TTGTAAGACAGCCTGTGCTCCCTCGCTCCTTCCTCTGCATTGCCCCTCTTCTCCCTCTCCAAACAGAGGGAACTCTCCTACCCCCAAGGA
GGTGAAAGCTGCTACCACCTCTGTGCCCCCCCGGCAATGCACCAACTGGATCCTACCCGAATTTATGATTAAGATTGCTGAAGAGCTGCC
AAACACTGCTGCCACCCCCTCTGTTCCCTTATTGCTGCTTGTCACTGCCTGACATTCACGGCAGAGGCAAGGCTGCTGCAGCTCCGCTGG
CTGTGCACATTCCCTCCTGCTCCCCAGAGACTGCCTCCGCCATCCCACAGATGATGGATCTTCAGTGGGTTCTCTTGGGCTCTAGGTCCC
GGAGAATGTTGTGAGGGGTTTATTTTTTTTTAATAGTGTTCATAAAGAAAGACATAGTATTCTTCTTCTCAAGACGTGGGGGGAAATTAT

>10165_10165_4_BRCC3-TRAC_BRCC3_chrX_154345029_ENST00000369462_TRAC_chr14_23016444_ENST00000478163_length(amino acids)=407AA_BP=266
MAVQVVQAVQAVHLESDAFLVCLNHALSTEKEEVMGLCIGELNDDTRSDSKFAYTGTEMRTVAEKVDAVRIVHIHSVIILRRSDKRKDRV
EISPEQLSAASTEAERLAELTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIFSCFIEDKNTKTGRVLYTCFQSIQAQK
SSESLHGPRDFWSSSQHISIEGQKEEERYERIEIPIHIVPHVTIGKVCLESAVELPKILCQEEQDAYRRIHSLTHLDSVTKIHNGSDIQN
PDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFPSPESS

--------------------------------------------------------------
>10165_10165_5_BRCC3-TRAC_BRCC3_chrX_154345029_ENST00000399042_TRAC_chr14_23016444_ENST00000478163_length(transcript)=1773nt_BP=799nt
ATGGCGGTGCAGGTGGTGCAGGCGGTGCAGGCGGTTCATCTCGAGTCTGACGCTTTCCTCGTTTGTCTCAACCACGCTCTGAGCACAGAG
AAGGAGGAAGTAATGGGGCTGTGCATAGGGGAGGTGAGTAGTCCCAGTAGGAGTGACTCCAAATTTGCATATACTGGAACTGAAATGCGC
ACAGTTGCTGAAAAGGTTGATGCCGTCAGAATTGTTCACATTCATTCTGTCATCATCTTACGACGTTCTGATAAGAGGAAGGACCGAGTA
GAAATTTCTCCAGAGCAGCTGTCTGCAGCTTCAACAGAGACACACAGGTTGGCTGAACTGACAGGCCGCCCCATGAGAGTTGTGGGCTGG
TATCATTCCCATCCTCATATAACTGTTTGGCCTTCACATGTTGATGTTCGCACACAAGCCATGTACCAGATGATGGATCAAGGCTTTGTA
GGACTTATTTTTTCCTGTTTCATAGAAGATAAGAACACAAAGACTGGCCGGGTACTCTACACTTGCTTCCAATCCATACAGGCCCAAAAG
AGTTCAGAGTCCCTTCATGGTCCACGAGACTTCTGGAGCTCCAGCCAGCACATCTCCATTGAGGGCCAGAAGGAAGAGGAAAGGTATGAG
AGAATCGAAATCCCAATCCATATTGTACCTCATGTCACTATCGGGAAAGTGTGCCTTGAATCAGCAGTAGAGCTGCCCAAGATCCTGTGC
CAGGAGGAGCAGGATGCGTATAGGAGGATCCACAGCCTTACACATCTGGACTCAGTAACCAAGATCCATAATGGCTCAGATATCCAGAAC
CCTGACCCTGCCGTGTACCAGCTGAGAGACTCTAAATCCAGTGACAAGTCTGTCTGCCTATTCACCGATTTTGATTCTCAAACAAATGTG
TCACAAAGTAAGGATTCTGATGTGTATATCACAGACAAAACTGTGCTAGACATGAGGTCTATGGACTTCAAGAGCAACAGTGCTGTGGCC
TGGAGCAACAAATCTGACTTTGCATGTGCAAACGCCTTCAACAACAGCATTATTCCAGAAGACACCTTCTTCCCCAGCCCAGAAAGTTCC
TGTGATGTCAAGCTGGTCGAGAAAAGCTTTGAAACAGATACGAACCTAAACTTTCAAAACCTGTCAGTGATTGGGTTCCGAATCCTCCTC
CTGAAAGTGGCCGGGTTTAATCTGCTCATGACGCTGCGGCTGTGGTCCAGCTGAGATCTGCAAGATTGTAAGACAGCCTGTGCTCCCTCG
CTCCTTCCTCTGCATTGCCCCTCTTCTCCCTCTCCAAACAGAGGGAACTCTCCTACCCCCAAGGAGGTGAAAGCTGCTACCACCTCTGTG
CCCCCCCGGCAATGCACCAACTGGATCCTACCCGAATTTATGATTAAGATTGCTGAAGAGCTGCCAAACACTGCTGCCACCCCCTCTGTT
CCCTTATTGCTGCTTGTCACTGCCTGACATTCACGGCAGAGGCAAGGCTGCTGCAGCTCCGCTGGCTGTGCACATTCCCTCCTGCTCCCC
AGAGACTGCCTCCGCCATCCCACAGATGATGGATCTTCAGTGGGTTCTCTTGGGCTCTAGGTCCCGGAGAATGTTGTGAGGGGTTTATTT
TTTTTTAATAGTGTTCATAAAGAAAGACATAGTATTCTTCTTCTCAAGACGTGGGGGGAAATTATCTCATTATCGAGGCCCTGCTATGCT

>10165_10165_5_BRCC3-TRAC_BRCC3_chrX_154345029_ENST00000399042_TRAC_chr14_23016444_ENST00000478163_length(amino acids)=407AA_BP=266
MAVQVVQAVQAVHLESDAFLVCLNHALSTEKEEVMGLCIGEVSSPSRSDSKFAYTGTEMRTVAEKVDAVRIVHIHSVIILRRSDKRKDRV
EISPEQLSAASTETHRLAELTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIFSCFIEDKNTKTGRVLYTCFQSIQAQK
SSESLHGPRDFWSSSQHISIEGQKEEERYERIEIPIHIVPHVTIGKVCLESAVELPKILCQEEQDAYRRIHSLTHLDSVTKIHNGSDIQN
PDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFPSPESS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for BRCC3-TRAC

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for BRCC3-TRAC

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for BRCC3-TRAC

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source