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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF236-QRSL1 (FusionGDB2 ID:101678)

Fusion Gene Summary for ZNF236-QRSL1

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF236-QRSL1
Fusion gene ID: 101678
HgeneTgene
Gene symbol

ZNF236

QRSL1

Gene ID

7776

55278

Gene namezinc finger protein 236glutaminyl-tRNA amidotransferase subunit QRSL1
SynonymsZNF236A|ZNF236BGatA
Cytomap

18q23

6q21

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 236regulated by glucoseglutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrialQRSL1, glutaminyl-tRNA amidotransferase subunit Aglu-AdT subunit Aglutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1glutaminyl-tRNA synthase-like protein 1glutamyl-tRNA(Gln) amidotransf
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000583095, ENST00000253159, 
ENST00000320610, 		ENST00000369046, 
ENST00000369044, ENST00000467262, 
Fusion gene scores* DoF score6 X 6 X 4=1449 X 9 X 5=405
# samples 613
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/405*10)=-1.63941028474353
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF236 [Title/Abstract] AND QRSL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF236(74563895)-QRSL1(107088224), # samples:5
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneQRSL1

GO:0070681

glutaminyl-tRNAGln biosynthesis via transamidation

19805282


check buttonFusion gene breakpoints across ZNF236 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across QRSL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-K1-A42X-01AZNF236chr18

74563895

-QRSL1chr6

107088224

+
ChimerDB4SARCTCGA-K1-A42X-01AZNF236chr18

74563895

+QRSL1chr6

107088224

+
ChimerDB4SARCTCGA-K1-A42X-02AZNF236chr18

74563895

-QRSL1chr6

107088224

+
ChimerDB4SARCTCGA-K1-A42X-02AZNF236chr18

74563895

+QRSL1chr6

107088224

+


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Fusion Gene ORF analysis for ZNF236-QRSL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000583095ENST00000369046ZNF236chr18

74563895

+QRSL1chr6

107088224

+
3UTR-3UTRENST00000583095ENST00000369044ZNF236chr18

74563895

+QRSL1chr6

107088224

+
3UTR-3UTRENST00000583095ENST00000467262ZNF236chr18

74563895

+QRSL1chr6

107088224

+
5CDS-3UTRENST00000253159ENST00000369044ZNF236chr18

74563895

+QRSL1chr6

107088224

+
5CDS-3UTRENST00000253159ENST00000467262ZNF236chr18

74563895

+QRSL1chr6

107088224

+
5CDS-3UTRENST00000320610ENST00000369044ZNF236chr18

74563895

+QRSL1chr6

107088224

+
5CDS-3UTRENST00000320610ENST00000467262ZNF236chr18

74563895

+QRSL1chr6

107088224

+
In-frameENST00000253159ENST00000369046ZNF236chr18

74563895

+QRSL1chr6

107088224

+
In-frameENST00000320610ENST00000369046ZNF236chr18

74563895

+QRSL1chr6

107088224

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000320610ZNF236chr1874563895+ENST00000369046QRSL1chr6107088224+434236411926641
ENST00000253159ZNF236chr1874563895+ENST00000369046QRSL1chr6107088224+45335551982117639

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000320610ENST00000369046ZNF236chr1874563895+QRSL1chr6107088224+0.0004007280.9995993
ENST00000253159ENST00000369046ZNF236chr1874563895+QRSL1chr6107088224+0.0002282860.9997718

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Fusion Genomic Features for ZNF236-QRSL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ZNF236chr1874563895+QRSL1chr6107088223+2.98E-070.99999976
ZNF236chr1874563895+QRSL1chr6107088223+2.98E-070.99999976
ZNF236chr1874563895+QRSL1chr6107088223+2.98E-070.99999976
ZNF236chr1874563895+QRSL1chr6107088223+2.98E-070.99999976

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ZNF236-QRSL1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:74563895/chr6:107088224)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF236chr18:74563895chr6:107088224ENST00000253159+33137_591191846.0Zinc fingerC2H2-type 1
HgeneZNF236chr18:74563895chr6:107088224ENST00000253159+33166_881191846.0Zinc fingerC2H2-type 2
HgeneZNF236chr18:74563895chr6:107088224ENST00000253159+33193_1151191846.0Zinc fingerC2H2-type 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF236chr18:74563895chr6:107088224ENST00000253159+3311023_10451191846.0Zinc fingerC2H2-type 20
HgeneZNF236chr18:74563895chr6:107088224ENST00000253159+3311051_10731191846.0Zinc fingerC2H2-type 21
HgeneZNF236chr18:74563895chr6:107088224ENST00000253159+3311167_11891191846.0Zinc fingerC2H2-type 22
HgeneZNF236chr18:74563895chr6:107088224ENST00000253159+3311195_12171191846.0Zinc fingerC2H2-type 23
HgeneZNF236chr18:74563895chr6:107088224ENST00000253159+331121_1431191846.0Zinc fingerC2H2-type 4
HgeneZNF236chr18:74563895chr6:107088224ENST00000253159+3311223_12451191846.0Zinc fingerC2H2-type 24
HgeneZNF236chr18:74563895chr6:107088224ENST00000253159+3311251_12731191846.0Zinc fingerC2H2-type 25
HgeneZNF236chr18:74563895chr6:107088224ENST00000253159+331153_1751191846.0Zinc fingerC2H2-type 5
HgeneZNF236chr18:74563895chr6:107088224ENST00000253159+3311657_16801191846.0Zinc fingerC2H2-type 26
HgeneZNF236chr18:74563895chr6:107088224ENST00000253159+3311686_17081191846.0Zinc fingerC2H2-type 27
HgeneZNF236chr18:74563895chr6:107088224ENST00000253159+3311722_17441191846.0Zinc fingerC2H2-type 28
HgeneZNF236chr18:74563895chr6:107088224ENST00000253159+3311750_17721191846.0Zinc fingerC2H2-type 29
HgeneZNF236chr18:74563895chr6:107088224ENST00000253159+3311778_18011191846.0Zinc fingerC2H2-type 30
HgeneZNF236chr18:74563895chr6:107088224ENST00000253159+331197_2191191846.0Zinc fingerC2H2-type 6
HgeneZNF236chr18:74563895chr6:107088224ENST00000253159+331225_2471191846.0Zinc fingerC2H2-type 7
HgeneZNF236chr18:74563895chr6:107088224ENST00000253159+331253_2761191846.0Zinc fingerC2H2-type 8
HgeneZNF236chr18:74563895chr6:107088224ENST00000253159+331285_3081191846.0Zinc fingerC2H2-type 9
HgeneZNF236chr18:74563895chr6:107088224ENST00000253159+331482_5041191846.0Zinc fingerC2H2-type 10
HgeneZNF236chr18:74563895chr6:107088224ENST00000253159+331510_5321191846.0Zinc fingerC2H2-type 11
HgeneZNF236chr18:74563895chr6:107088224ENST00000253159+331538_5601191846.0Zinc fingerC2H2-type 12
HgeneZNF236chr18:74563895chr6:107088224ENST00000253159+331566_5881191846.0Zinc fingerC2H2-type 13
HgeneZNF236chr18:74563895chr6:107088224ENST00000253159+331657_6791191846.0Zinc fingerC2H2-type 14
HgeneZNF236chr18:74563895chr6:107088224ENST00000253159+331685_7071191846.0Zinc fingerC2H2-type 15
HgeneZNF236chr18:74563895chr6:107088224ENST00000253159+331713_7351191846.0Zinc fingerC2H2-type 16
HgeneZNF236chr18:74563895chr6:107088224ENST00000253159+331741_7631191846.0Zinc fingerC2H2-type 17
HgeneZNF236chr18:74563895chr6:107088224ENST00000253159+331967_9891191846.0Zinc fingerC2H2-type 18
HgeneZNF236chr18:74563895chr6:107088224ENST00000253159+331995_10171191846.0Zinc fingerC2H2-type 19


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Fusion Gene Sequence for ZNF236-QRSL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>101678_101678_1_ZNF236-QRSL1_ZNF236_chr18_74563895_ENST00000253159_QRSL1_chr6_107088224_ENST00000369046_length(transcript)=4533nt_BP=555nt
GCCTGGAAACTACAAAGGATTGTGTTAATTTTGTGTTTAGGAAGAAAGAGGTAATGGGTAGGAATCAATGTAAACTTATTCATAGGCCAC
ACCAAACCAGGAATTCTTGTCGTGATTGCACTTGGTAGAGTTAACACACGTGCACATTACGGAAACGTTGGTGACCAACAGGCGTTTCAG
CGAGCTTTCGCACACCTCATGGGCCTTTGTGGGCTGCTGGAGAGATGTTGGCTGCACCATGACCCAGATGGAGTTTTAACATTGAATGCG
GAGAACACTAATTATGCCTATCAAGTTCCAAACTTCCATAAATGTGAAATCTGTCTACTATCTTTTCCAAAAGAATCCCAGTTTCAACGC
CACATGAGGGATCACGAGCGAAATGACAAGCCACATCGATGTGACCAGTGCCCCCAAACATTTAATGTTGAATTCAACCTGACACTTCAT
AAATGCACCCACAGCGGGGAAGATCCTACCTGCCCTGTGTGTAACAAGAAATTCTCCAGAGTGGCTAGTCTCAAAGCGCATATTATGCTA
CATGAAAAGGAAGAGGTTTCTGCGGCACTGAAACAAGGCCAAATTACACCAACAGAGCTCTGTCAAAAATGTCTCTCTCTTATCAAGAAG
ACCAAGTTTCTAAATGCCTACATTACTGTGTCAGAAGAGGTGGCCTTAAAACAAGCTGAAGAATCAGAAAAGAGATATAAGAATGGACAG
TCACTTGGGGATTTAGATGGAATTCCTATTGCAGTAAAAGACAATTTCAGCACTTCTGGCATTGAGACAACATGTGCATCAAATATGCTG
AAAGGTTATATACCACCTTATAATGCTACAGTAGTTCAGAAGTTGTTGGATCAGGGAGCTCTACTAATGGGAAAAACAAATTTAGATGAG
TTTGCTATGGGATCTGGGAGCACAGATGGTGTATTTGGACCAGTTAAAAACCCCTGGAGTTATTCAAAACAATATAGAGAAAAGAGGAAG
CAGAATCCCCACAGCGAGAATGAAGATTCAGACTGGCTGATAACTGGAGGAAGCTCAGGTGGGAGTGCAGCTGCTGTATCGGCGTTCACA
TGCTACGCGGCTTTAGGATCAGATACAGGAGGATCGACCAGAAATCCTGCTGCCCACTGTGGGCTTGTTGGTTTCAAACCAAGCTATGGC
TTAGTTTCCCGTCATGGTCTCATTCCCCTGGTGAATTCGATGGATGTGCCAGGAATCTTAACCAGATGTGTGGATGATGCAGCAATTGTG
TTGGGTGCACTGGCCGGACCTGACCCCAGGGACTCTACCACAGTACATGAACCTATTAATAAACCATTCATGCTTCCCAGTTTGGCAGAT
GTGAGCAAACTATGTATAGGAATTCCAAAGGAATATCTTGTACCGGAATTATCAAGTGAAGTACAGTCTCTTTGGTCCAAAGCTGCTGAC
CTCTTTGAGTCTGAGGGGGCCAAAGTAATTGAAGTATCCCTTCCTCACACCAGTTATTCAATTGTCTGCTACCATGTATTGTGCACATCA
GAAGTGGCATCGAATATGGCAAGATTTGATGGGCTACAATATGGTCACAGATGTGACATTGATGTGTCCACTGAAGCCATGTATGCTGCA
ACCAGACGAGAAGGGTTTAATGATGTGGTGAGAGGAAGAATTCTCTCAGGAAACTTTTTCTTATTAAAAGAAAACTATGAAAATTATTTT
GTCAAAGCACAGAAAGTGAGACGCCTCATTGCTAATGACTTTGTAAATGCTTTTAACTCTGGAGTAGATGTCTTGCTAACTCCCACCACC
TTGAGTGAGGCAGTACCATACTTGGAGTTCATCAAAGAGGACAACAGAACCCGAAGTGCCCAGGATGATATTTTTACACAAGCTGTAAAT
ATGGCAGGATTGCCAGCAGTGAGTATCCCTGTTGCACTCTCAAACCAAGGGTTGCCAATAGGACTGCAGTTTATTGGACGTGCGTTTTGT
GACCAGCAGCTTCTTACAGTAGCCAAATGGTTTGAAAAACAAGTACAGTTTCCTGTTATTCAACTTCAAGAACTCATGGATGATTGTTCA
GCAGTCCTTGAAAATGAAAAGTTAGCCTCTGTCTCTCTAAAACAGTAAACATATCTTACAAATTAAAATGACTTTTAGGCTGGGTGCAGT
GGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGAGCGGATCATGAGGTCAGAAGATCTAGAACAGCCTGGTCAACATGGTGA
AACCCCGTCTCTACTAAAAATACAAAAATTAGCCAGGCTTAGTGGCGGGCATCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAA
TCACTTGAACCCTGGAGGTGGAGGTTGCAGTGAGCCGAGATCATGCCACTGCACTGCACTCCAGCCTGGGTGACAAAGCAAGACTGTGTC
TCAAAATAAATAAATAAAATAAAATAAAATGACGTACAGAGATTCTATATTCTAGAGAGTCAAATGGTCTTGCTCAATTCTTGTAATTAG
GTTCTTGTTAATACAGTCATTCCATGGAATTACTTTTTAAAATTCCTGTGACAATTAATAATAAATAACGTGTCAGCATTTAGTAAGCAT
CCACTAAGTGTACAATACTTCTACAATAACACAAGATACCTGTTCCTCAAAGACAATGCATTCTGCCATAATGTTCATTAAAGAGTTTAC
AGTAAAAATAAGATTAGGGATAAACTTCTCAAAAATTGTACATCTGTGTAACTAAAGCACTAACAAAAACATGAATAGTCCTTCTAGAGG
TAACTTGGATAGCCTAGGCAGGCAACTTATCATGTGGTGAAGGCCGCCTCAGGGGTTGTTAAAAATGCACAGAAACAATTGAGTGCGATT
ATTGGCTTCTGAGCGCTGAGCAGAGCAGGTGGAAGAGGAACTTTGAGCACAGGAGGAAATGCAACCAGTCAGGGCCCAGAATCATGCAAA
TCTCAGGGGTATGCCTCTCTGGGGAGGAGCTCCACTTGCAGGGACTCCTTTTATTTCCCTAAGAAAGAGCTGAAATGACTGAGAACTTTC
CTTTCCTCCTTAGAGTTACAATTTTACTTCTGCTATTCCGGAGCCCATGCCTAGAAGCCAGAACAACTCCATGTTACACTGAGTTCATGC
TCCTATTTACTGATCACAAATGAGCTCATTAATGTCATCGAAACATTTATTGTAACCTAACAGACCATCACAGATTGGAAACTTGGTAGA
TAGCAGAGCATGGTATTAGTGAAAAAGGTTCAAAATACACAAGTAACATACACTCTGAAAAACATGCAGATAATTTGCTGATGAAGCAGA
AGAGGGGATGCGCATGGCAAGAACTTGCCTTACCCCAGATTCTCTATATCTCATGGTTTCCTTTTCCTCTTGACTGTCTTTACGAGTGTT
TTTTATTTGGGACCCTCGAGCCCAGAGATATTAATGGATATCTGTATTCAATATTTGACAAAATCTAATGGAAACCATCCATTTACTCAT
GATAAGGCTTCATCACTGGATTTCTGTGTCTTCACTAGAACACCATTGTCATCTCATATTGATCAGGTATTTTAATCTAGCACTTACATA
TTGTTGATAAATGAAAGCTGAATTGTTACTTAATAAATTCACTTTGTTTAGTAAAAAAAAATTGTTTTCTAAATATGACGTTCATGAAGA
GAAAATAATGAGTCAGAATCATCTGCAGAACCACTGGAATGTTTCATCGTCACCTGTTAGTTTTCATAAACAGTTTTCTGTCCTCTCTGA
GATCCTCCCGCTCCCAAATACTCAACCTGATTAACTTCACATAAAAGTCTTATGTGCCAGGCTTAGTAATATTCCTATAGATTTTGACTC
TGAATCCCTGAAAGAGGAAGAAATCCATGAGAGAAAATTGCATTACTTTATAGCAAGAGGAAACCGTTTTAAGTTTTTTAATTGCTCAGA
CACCACAACATCCTAGATGGAGGAAACCATTTTAGTTGAAGGAGCAAATATGATGTCAAAAGCAAGTAAATAAACAAACCGTTGCCCCAA
TCTGTTTTTATGTAATGAATTTAAAAAAAAAGAGAGAGAGAGAGAGATGGGCTCTCCCTGTGTTGCCCAGGCTAGTCTCAAACTCCTGGG
CTCAAGTGATCTGCCTCCCTCAGCCTCCCAAAGTGCTGAGATTAAAGACGTGAGCCACCACACCTGGCCGAAATAATAATATTCAATATT
ATATATTCAATGATATTATTCAGTATTCAATATTATTTCAAATAATATTAAATCTCTTGTTCCTGTATCTCTACATGAGCTGCACTAATA
ATTTGAATCTGGAAATTAAAAAGTGAAACATTTACCGTTCTCATATACTGATACCCAACTACCATGAAATGATACCTAATTTGTTTTTCT
TTTCTCTTCATTTTTACTCTTAATCTAGTAGGTCTCATTTTGCCAAGTCACTGTCTGGGAATTTAAGTGGCAAATACTTTCTTTGTCTCA

>101678_101678_1_ZNF236-QRSL1_ZNF236_chr18_74563895_ENST00000253159_QRSL1_chr6_107088224_ENST00000369046_length(amino acids)=639AA_BP=119
MGLCGLLERCWLHHDPDGVLTLNAENTNYAYQVPNFHKCEICLLSFPKESQFQRHMRDHERNDKPHRCDQCPQTFNVEFNLTLHKCTHSG
EDPTCPVCNKKFSRVASLKAHIMLHEKEEVSAALKQGQITPTELCQKCLSLIKKTKFLNAYITVSEEVALKQAEESEKRYKNGQSLGDLD
GIPIAVKDNFSTSGIETTCASNMLKGYIPPYNATVVQKLLDQGALLMGKTNLDEFAMGSGSTDGVFGPVKNPWSYSKQYREKRKQNPHSE
NEDSDWLITGGSSGGSAAAVSAFTCYAALGSDTGGSTRNPAAHCGLVGFKPSYGLVSRHGLIPLVNSMDVPGILTRCVDDAAIVLGALAG
PDPRDSTTVHEPINKPFMLPSLADVSKLCIGIPKEYLVPELSSEVQSLWSKAADLFESEGAKVIEVSLPHTSYSIVCYHVLCTSEVASNM
ARFDGLQYGHRCDIDVSTEAMYAATRREGFNDVVRGRILSGNFFLLKENYENYFVKAQKVRRLIANDFVNAFNSGVDVLLTPTTLSEAVP
YLEFIKEDNRTRSAQDDIFTQAVNMAGLPAVSIPVALSNQGLPIGLQFIGRAFCDQQLLTVAKWFEKQVQFPVIQLQELMDDCSAVLENE

--------------------------------------------------------------
>101678_101678_2_ZNF236-QRSL1_ZNF236_chr18_74563895_ENST00000320610_QRSL1_chr6_107088224_ENST00000369046_length(transcript)=4342nt_BP=364nt
GATGCCGCGGGGCCGCCCCCCGAAGCCCAGGGAGAGCAAGGCGCGCGGCGACTCCGATGGAGTTTTAACATTGAATGCGGAGAACACTAA
TTATGCCTATCAAGTTCCAAACTTCCATAAATGTGAAATCTGTCTACTATCTTTTCCAAAAGAATCCCAGTTTCAACGCCACATGAGGGA
TCACGAGCGAAATGACAAGCCACATCGATGTGACCAGTGCCCCCAAACATTTAATGTTGAATTCAACCTGACACTTCATAAATGCACCCA
CAGCGGGGAAGATCCTACCTGCCCTGTGTGTAACAAGAAATTCTCCAGAGTGGCTAGTCTCAAAGCGCATATTATGCTACATGAAAAGGA
AGAGGTTTCTGCGGCACTGAAACAAGGCCAAATTACACCAACAGAGCTCTGTCAAAAATGTCTCTCTCTTATCAAGAAGACCAAGTTTCT
AAATGCCTACATTACTGTGTCAGAAGAGGTGGCCTTAAAACAAGCTGAAGAATCAGAAAAGAGATATAAGAATGGACAGTCACTTGGGGA
TTTAGATGGAATTCCTATTGCAGTAAAAGACAATTTCAGCACTTCTGGCATTGAGACAACATGTGCATCAAATATGCTGAAAGGTTATAT
ACCACCTTATAATGCTACAGTAGTTCAGAAGTTGTTGGATCAGGGAGCTCTACTAATGGGAAAAACAAATTTAGATGAGTTTGCTATGGG
ATCTGGGAGCACAGATGGTGTATTTGGACCAGTTAAAAACCCCTGGAGTTATTCAAAACAATATAGAGAAAAGAGGAAGCAGAATCCCCA
CAGCGAGAATGAAGATTCAGACTGGCTGATAACTGGAGGAAGCTCAGGTGGGAGTGCAGCTGCTGTATCGGCGTTCACATGCTACGCGGC
TTTAGGATCAGATACAGGAGGATCGACCAGAAATCCTGCTGCCCACTGTGGGCTTGTTGGTTTCAAACCAAGCTATGGCTTAGTTTCCCG
TCATGGTCTCATTCCCCTGGTGAATTCGATGGATGTGCCAGGAATCTTAACCAGATGTGTGGATGATGCAGCAATTGTGTTGGGTGCACT
GGCCGGACCTGACCCCAGGGACTCTACCACAGTACATGAACCTATTAATAAACCATTCATGCTTCCCAGTTTGGCAGATGTGAGCAAACT
ATGTATAGGAATTCCAAAGGAATATCTTGTACCGGAATTATCAAGTGAAGTACAGTCTCTTTGGTCCAAAGCTGCTGACCTCTTTGAGTC
TGAGGGGGCCAAAGTAATTGAAGTATCCCTTCCTCACACCAGTTATTCAATTGTCTGCTACCATGTATTGTGCACATCAGAAGTGGCATC
GAATATGGCAAGATTTGATGGGCTACAATATGGTCACAGATGTGACATTGATGTGTCCACTGAAGCCATGTATGCTGCAACCAGACGAGA
AGGGTTTAATGATGTGGTGAGAGGAAGAATTCTCTCAGGAAACTTTTTCTTATTAAAAGAAAACTATGAAAATTATTTTGTCAAAGCACA
GAAAGTGAGACGCCTCATTGCTAATGACTTTGTAAATGCTTTTAACTCTGGAGTAGATGTCTTGCTAACTCCCACCACCTTGAGTGAGGC
AGTACCATACTTGGAGTTCATCAAAGAGGACAACAGAACCCGAAGTGCCCAGGATGATATTTTTACACAAGCTGTAAATATGGCAGGATT
GCCAGCAGTGAGTATCCCTGTTGCACTCTCAAACCAAGGGTTGCCAATAGGACTGCAGTTTATTGGACGTGCGTTTTGTGACCAGCAGCT
TCTTACAGTAGCCAAATGGTTTGAAAAACAAGTACAGTTTCCTGTTATTCAACTTCAAGAACTCATGGATGATTGTTCAGCAGTCCTTGA
AAATGAAAAGTTAGCCTCTGTCTCTCTAAAACAGTAAACATATCTTACAAATTAAAATGACTTTTAGGCTGGGTGCAGTGGCTCACACCT
GTAATCCCAGCACTTTGGGAGGCCAAGGCGAGCGGATCATGAGGTCAGAAGATCTAGAACAGCCTGGTCAACATGGTGAAACCCCGTCTC
TACTAAAAATACAAAAATTAGCCAGGCTTAGTGGCGGGCATCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACC
CTGGAGGTGGAGGTTGCAGTGAGCCGAGATCATGCCACTGCACTGCACTCCAGCCTGGGTGACAAAGCAAGACTGTGTCTCAAAATAAAT
AAATAAAATAAAATAAAATGACGTACAGAGATTCTATATTCTAGAGAGTCAAATGGTCTTGCTCAATTCTTGTAATTAGGTTCTTGTTAA
TACAGTCATTCCATGGAATTACTTTTTAAAATTCCTGTGACAATTAATAATAAATAACGTGTCAGCATTTAGTAAGCATCCACTAAGTGT
ACAATACTTCTACAATAACACAAGATACCTGTTCCTCAAAGACAATGCATTCTGCCATAATGTTCATTAAAGAGTTTACAGTAAAAATAA
GATTAGGGATAAACTTCTCAAAAATTGTACATCTGTGTAACTAAAGCACTAACAAAAACATGAATAGTCCTTCTAGAGGTAACTTGGATA
GCCTAGGCAGGCAACTTATCATGTGGTGAAGGCCGCCTCAGGGGTTGTTAAAAATGCACAGAAACAATTGAGTGCGATTATTGGCTTCTG
AGCGCTGAGCAGAGCAGGTGGAAGAGGAACTTTGAGCACAGGAGGAAATGCAACCAGTCAGGGCCCAGAATCATGCAAATCTCAGGGGTA
TGCCTCTCTGGGGAGGAGCTCCACTTGCAGGGACTCCTTTTATTTCCCTAAGAAAGAGCTGAAATGACTGAGAACTTTCCTTTCCTCCTT
AGAGTTACAATTTTACTTCTGCTATTCCGGAGCCCATGCCTAGAAGCCAGAACAACTCCATGTTACACTGAGTTCATGCTCCTATTTACT
GATCACAAATGAGCTCATTAATGTCATCGAAACATTTATTGTAACCTAACAGACCATCACAGATTGGAAACTTGGTAGATAGCAGAGCAT
GGTATTAGTGAAAAAGGTTCAAAATACACAAGTAACATACACTCTGAAAAACATGCAGATAATTTGCTGATGAAGCAGAAGAGGGGATGC
GCATGGCAAGAACTTGCCTTACCCCAGATTCTCTATATCTCATGGTTTCCTTTTCCTCTTGACTGTCTTTACGAGTGTTTTTTATTTGGG
ACCCTCGAGCCCAGAGATATTAATGGATATCTGTATTCAATATTTGACAAAATCTAATGGAAACCATCCATTTACTCATGATAAGGCTTC
ATCACTGGATTTCTGTGTCTTCACTAGAACACCATTGTCATCTCATATTGATCAGGTATTTTAATCTAGCACTTACATATTGTTGATAAA
TGAAAGCTGAATTGTTACTTAATAAATTCACTTTGTTTAGTAAAAAAAAATTGTTTTCTAAATATGACGTTCATGAAGAGAAAATAATGA
GTCAGAATCATCTGCAGAACCACTGGAATGTTTCATCGTCACCTGTTAGTTTTCATAAACAGTTTTCTGTCCTCTCTGAGATCCTCCCGC
TCCCAAATACTCAACCTGATTAACTTCACATAAAAGTCTTATGTGCCAGGCTTAGTAATATTCCTATAGATTTTGACTCTGAATCCCTGA
AAGAGGAAGAAATCCATGAGAGAAAATTGCATTACTTTATAGCAAGAGGAAACCGTTTTAAGTTTTTTAATTGCTCAGACACCACAACAT
CCTAGATGGAGGAAACCATTTTAGTTGAAGGAGCAAATATGATGTCAAAAGCAAGTAAATAAACAAACCGTTGCCCCAATCTGTTTTTAT
GTAATGAATTTAAAAAAAAAGAGAGAGAGAGAGAGATGGGCTCTCCCTGTGTTGCCCAGGCTAGTCTCAAACTCCTGGGCTCAAGTGATC
TGCCTCCCTCAGCCTCCCAAAGTGCTGAGATTAAAGACGTGAGCCACCACACCTGGCCGAAATAATAATATTCAATATTATATATTCAAT
GATATTATTCAGTATTCAATATTATTTCAAATAATATTAAATCTCTTGTTCCTGTATCTCTACATGAGCTGCACTAATAATTTGAATCTG
GAAATTAAAAAGTGAAACATTTACCGTTCTCATATACTGATACCCAACTACCATGAAATGATACCTAATTTGTTTTTCTTTTCTCTTCAT
TTTTACTCTTAATCTAGTAGGTCTCATTTTGCCAAGTCACTGTCTGGGAATTTAAGTGGCAAATACTTTCTTTGTCTCAGCTAATTAAAC

>101678_101678_2_ZNF236-QRSL1_ZNF236_chr18_74563895_ENST00000320610_QRSL1_chr6_107088224_ENST00000369046_length(amino acids)=641AA_BP=121
MPRGRPPKPRESKARGDSDGVLTLNAENTNYAYQVPNFHKCEICLLSFPKESQFQRHMRDHERNDKPHRCDQCPQTFNVEFNLTLHKCTH
SGEDPTCPVCNKKFSRVASLKAHIMLHEKEEVSAALKQGQITPTELCQKCLSLIKKTKFLNAYITVSEEVALKQAEESEKRYKNGQSLGD
LDGIPIAVKDNFSTSGIETTCASNMLKGYIPPYNATVVQKLLDQGALLMGKTNLDEFAMGSGSTDGVFGPVKNPWSYSKQYREKRKQNPH
SENEDSDWLITGGSSGGSAAAVSAFTCYAALGSDTGGSTRNPAAHCGLVGFKPSYGLVSRHGLIPLVNSMDVPGILTRCVDDAAIVLGAL
AGPDPRDSTTVHEPINKPFMLPSLADVSKLCIGIPKEYLVPELSSEVQSLWSKAADLFESEGAKVIEVSLPHTSYSIVCYHVLCTSEVAS
NMARFDGLQYGHRCDIDVSTEAMYAATRREGFNDVVRGRILSGNFFLLKENYENYFVKAQKVRRLIANDFVNAFNSGVDVLLTPTTLSEA
VPYLEFIKEDNRTRSAQDDIFTQAVNMAGLPAVSIPVALSNQGLPIGLQFIGRAFCDQQLLTVAKWFEKQVQFPVIQLQELMDDCSAVLE

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Fusion Gene PPI Analysis for ZNF236-QRSL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF236-QRSL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF236-QRSL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource