FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ZNF251-SRCAP (FusionGDB2 ID:101700)

Fusion Gene Summary for ZNF251-SRCAP

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF251-SRCAP
Fusion gene ID: 101700
HgeneTgene
Gene symbol

ZNF251

SRCAP

Gene ID

90987

10847

Gene namezinc finger protein 251Snf2 related CREBBP activator protein
Synonyms-DOMO1|EAF1|FLHS|SWR1
Cytomap

8q24.3

16p11.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 251helicase SRCAPSnf2-related CBP activator proteinSwi2/Snf2-related ATPase homolog, domino homolog 1domino homolog 2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000292562, ENST00000524394, 
ENST00000262518, ENST00000344771, 
ENST00000395059, 
Fusion gene scores* DoF score10 X 3 X 8=2406 X 7 X 4=168
# samples 108
** MAII scorelog2(10/240*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF251 [Title/Abstract] AND SRCAP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF251(145979068)-SRCAP(30740287), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ZNF251 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SRCAP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-C8-A132-01AZNF251chr8

145979068

-SRCAPchr16

30740287

+


Top

Fusion Gene ORF analysis for ZNF251-SRCAP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000292562ENST00000262518ZNF251chr8

145979068

-SRCAPchr16

30740287

+
In-frameENST00000292562ENST00000344771ZNF251chr8

145979068

-SRCAPchr16

30740287

+
In-frameENST00000292562ENST00000395059ZNF251chr8

145979068

-SRCAPchr16

30740287

+
intron-3CDSENST00000524394ENST00000262518ZNF251chr8

145979068

-SRCAPchr16

30740287

+
intron-3CDSENST00000524394ENST00000344771ZNF251chr8

145979068

-SRCAPchr16

30740287

+
intron-3CDSENST00000524394ENST00000395059ZNF251chr8

145979068

-SRCAPchr16

30740287

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000292562ZNF251chr8145979068-ENST00000344771SRCAPchr1630740287+498355355945871342
ENST00000292562ZNF251chr8145979068-ENST00000395059SRCAPchr1630740287+498355355945871342
ENST00000292562ZNF251chr8145979068-ENST00000262518SRCAPchr1630740287+498455355945871342

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000292562ENST00000344771ZNF251chr8145979068-SRCAPchr1630740287+0.0039515430.9960485
ENST00000292562ENST00000395059ZNF251chr8145979068-SRCAPchr1630740287+0.0039515430.9960485
ENST00000292562ENST00000262518ZNF251chr8145979068-SRCAPchr1630740287+0.0039993410.9960006

Top

Fusion Genomic Features for ZNF251-SRCAP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ZNF251chr8145979067-SRCAPchr1630740286+3.34E-121
ZNF251chr8145979067-SRCAPchr1630740286+3.34E-121

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for ZNF251-SRCAP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:145979068/chr16:30740287)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF251chr8:145979068chr16:30740287ENST00000292562-4515_8692672.0DomainKRAB
TgeneSRCAPchr8:145979068chr16:30740287ENST0000026251824342227_236218863231.0Compositional biasNote=Glu-rich
TgeneSRCAPchr8:145979068chr16:30740287ENST0000026251824342426_302318863231.0Compositional biasNote=Pro-rich
TgeneSRCAPchr8:145979068chr16:30740287ENST0000026251824343179_318218863231.0Compositional biasNote=Poly-Glu
TgeneSRCAPchr8:145979068chr16:30740287ENST0000034477122322227_236217283073.0Compositional biasNote=Glu-rich
TgeneSRCAPchr8:145979068chr16:30740287ENST0000034477122322426_302317283073.0Compositional biasNote=Pro-rich
TgeneSRCAPchr8:145979068chr16:30740287ENST0000034477122323179_318217283073.0Compositional biasNote=Poly-Glu
TgeneSRCAPchr8:145979068chr16:30740287ENST0000039505923332227_236218243169.0Compositional biasNote=Glu-rich
TgeneSRCAPchr8:145979068chr16:30740287ENST0000039505923332426_302318243169.0Compositional biasNote=Pro-rich
TgeneSRCAPchr8:145979068chr16:30740287ENST0000039505923333179_318218243169.0Compositional biasNote=Poly-Glu
TgeneSRCAPchr8:145979068chr16:30740287ENST0000026251824342857_286918863231.0DNA bindingNote=A.T hook 1
TgeneSRCAPchr8:145979068chr16:30740287ENST0000026251824342936_294818863231.0DNA bindingNote=A.T hook 2
TgeneSRCAPchr8:145979068chr16:30740287ENST0000026251824343004_301618863231.0DNA bindingNote=A.T hook 3
TgeneSRCAPchr8:145979068chr16:30740287ENST0000034477122322857_286917283073.0DNA bindingNote=A.T hook 1
TgeneSRCAPchr8:145979068chr16:30740287ENST0000034477122322936_294817283073.0DNA bindingNote=A.T hook 2
TgeneSRCAPchr8:145979068chr16:30740287ENST0000034477122323004_301617283073.0DNA bindingNote=A.T hook 3
TgeneSRCAPchr8:145979068chr16:30740287ENST0000039505923332857_286918243169.0DNA bindingNote=A.T hook 1
TgeneSRCAPchr8:145979068chr16:30740287ENST0000039505923332936_294818243169.0DNA bindingNote=A.T hook 2
TgeneSRCAPchr8:145979068chr16:30740287ENST0000039505923333004_301618243169.0DNA bindingNote=A.T hook 3
TgeneSRCAPchr8:145979068chr16:30740287ENST0000026251824342044_219718863231.0DomainHelicase C-terminal
TgeneSRCAPchr8:145979068chr16:30740287ENST0000034477122322044_219717283073.0DomainHelicase C-terminal
TgeneSRCAPchr8:145979068chr16:30740287ENST0000039505923332044_219718243169.0DomainHelicase C-terminal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF251chr8:145979068chr16:30740287ENST00000292562-45209_23192672.0Zinc fingerC2H2-type 1
HgeneZNF251chr8:145979068chr16:30740287ENST00000292562-45237_25992672.0Zinc fingerC2H2-type 2
HgeneZNF251chr8:145979068chr16:30740287ENST00000292562-45265_28792672.0Zinc fingerC2H2-type 3
HgeneZNF251chr8:145979068chr16:30740287ENST00000292562-45293_31592672.0Zinc fingerC2H2-type 4
HgeneZNF251chr8:145979068chr16:30740287ENST00000292562-45321_34392672.0Zinc fingerC2H2-type 5
HgeneZNF251chr8:145979068chr16:30740287ENST00000292562-45349_37192672.0Zinc fingerC2H2-type 6
HgeneZNF251chr8:145979068chr16:30740287ENST00000292562-45377_39992672.0Zinc fingerC2H2-type 7
HgeneZNF251chr8:145979068chr16:30740287ENST00000292562-45405_42792672.0Zinc fingerC2H2-type 8
HgeneZNF251chr8:145979068chr16:30740287ENST00000292562-45433_45592672.0Zinc fingerC2H2-type 9
HgeneZNF251chr8:145979068chr16:30740287ENST00000292562-45461_48392672.0Zinc fingerC2H2-type 10
HgeneZNF251chr8:145979068chr16:30740287ENST00000292562-45489_51192672.0Zinc fingerC2H2-type 11
HgeneZNF251chr8:145979068chr16:30740287ENST00000292562-45566_58892672.0Zinc fingerC2H2-type 12%3B degenerate
HgeneZNF251chr8:145979068chr16:30740287ENST00000292562-45594_61692672.0Zinc fingerC2H2-type 13
HgeneZNF251chr8:145979068chr16:30740287ENST00000292562-45622_64492672.0Zinc fingerC2H2-type 14%3B degenerate
TgeneSRCAPchr8:145979068chr16:30740287ENST000002625182434275_27818863231.0Compositional biasNote=Poly-Pro
TgeneSRCAPchr8:145979068chr16:30740287ENST000002625182434293_56318863231.0Compositional biasNote=Glu-rich
TgeneSRCAPchr8:145979068chr16:30740287ENST000002625182434981_188318863231.0Compositional biasNote=Pro-rich
TgeneSRCAPchr8:145979068chr16:30740287ENST000003447712232275_27817283073.0Compositional biasNote=Poly-Pro
TgeneSRCAPchr8:145979068chr16:30740287ENST000003447712232293_56317283073.0Compositional biasNote=Glu-rich
TgeneSRCAPchr8:145979068chr16:30740287ENST000003447712232981_188317283073.0Compositional biasNote=Pro-rich
TgeneSRCAPchr8:145979068chr16:30740287ENST000003950592333275_27818243169.0Compositional biasNote=Poly-Pro
TgeneSRCAPchr8:145979068chr16:30740287ENST000003950592333293_56318243169.0Compositional biasNote=Glu-rich
TgeneSRCAPchr8:145979068chr16:30740287ENST000003950592333981_188318243169.0Compositional biasNote=Pro-rich
TgeneSRCAPchr8:145979068chr16:30740287ENST000002625182434124_19618863231.0DomainHSA
TgeneSRCAPchr8:145979068chr16:30740287ENST000002625182434630_79518863231.0DomainHelicase ATP-binding
TgeneSRCAPchr8:145979068chr16:30740287ENST000003447712232124_19617283073.0DomainHSA
TgeneSRCAPchr8:145979068chr16:30740287ENST000003447712232630_79517283073.0DomainHelicase ATP-binding
TgeneSRCAPchr8:145979068chr16:30740287ENST000003950592333124_19618243169.0DomainHSA
TgeneSRCAPchr8:145979068chr16:30740287ENST000003950592333630_79518243169.0DomainHelicase ATP-binding
TgeneSRCAPchr8:145979068chr16:30740287ENST000002625182434643_65018863231.0Nucleotide bindingATP
TgeneSRCAPchr8:145979068chr16:30740287ENST000003447712232643_65017283073.0Nucleotide bindingATP
TgeneSRCAPchr8:145979068chr16:30740287ENST000003950592333643_65018243169.0Nucleotide bindingATP


Top

Fusion Gene Sequence for ZNF251-SRCAP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>101700_101700_1_ZNF251-SRCAP_ZNF251_chr8_145979068_ENST00000292562_SRCAP_chr16_30740287_ENST00000262518_length(transcript)=4984nt_BP=553nt
GCGTTCTCGGAGGCGTACTGAGGCCCCGCAGGGGGCGGGGAAGCCTGCGTGTGCGCAGCTCGGCCCGGCCCGCCCTCTTCATCCTAGCCC
GCCCCCTCCCCGGCTCTGGACCCGGTTCTGTGGGAGGGTCCGTTCCGGGCTCGGTGCGACTGCGCAGCTCCTCGGCGCTTCCTCGGTGGC
TTCCCCGGGTCGAGCAAACAGGTAAGTTCGGGGAGACTTCAGGCCAGGGCAGTCTCCTGTCTTCTCTTGGAAACCACAGCAGCCCATGCA
CACAGAATGGCAGCCACATTCCAGCTTCCAGGGCACCAGGAGATGCCGCTGACCTTCCAGGATGTGGCCGTGTACTTCTCTCAGGCGGAG
GGGCGGCAGCTGGGCCCCCAGCAGCGGGCGCTCTACCGGGATGTGATGCTGGAGAACTATGGGAACGTGGCCTCTCTGGGATTCCCTGTC
CCTAAGCCGGAGTTGATCTCCCAGCTGGAGCAGGGGAAGGAACTTTGGGTCCTGAATCTTCTGGGAGCTGAGGAACCAGATATCTTGAAA
AGCTGCCAGAAAGGACTCCCTGGAGGAAAAGCGGAAGCGGCAGCGGTCTGAACGCCTGGAACGGATTTTCCAACTTAGTGAGGCTCATGG
GGCCCTGGCACCTGTGTATGGGACTGAAGTCCTGGATTTCTGTACCCTGCCCCAACCTGTTGCCAGCCCCATCGGCCCTCGTTCTCCTGG
CCCCAGCCACCCCACCTTTTGGACTTATACCGAGGCTGCCCACCGGGCTGTACTGTTTCCCCAGCAGCGACTAGACCAGCTGTCAGAAAT
CATTGAGAGGTTCATCTTTGTCATGCCTCCTGTGGAGGCACCTCCCCCTTCCCTGCATGCCTGCCACCCACCTCCTTGGCTGGCCCCACG
TCAGGCAGCCTTCCAGGAGCAATTGGCCTCTGAGCTCTGGCCCCGGGCTCGTCCTTTGCACCGTATTGTGTGTAACATGCGCACCCAGTT
CCCTGACTTAAGACTCATCCAGTATGATTGCGGAAAGTTGCAGACGTTGGCAGTGCTGTTGCGGCAGCTCAAGGCAGAGGGCCACCGAGT
GCTCATCTTCACCCAGATGACCCGAATGCTGGATGTATTGGAGCAGTTTCTCACCTACCATGGCCATCTCTACCTGCGCCTGGATGGATC
TACTAGAGTTGAACAGAGACAGGCCTTGATGGAACGGTTCAATGCAGACAAACGCATATTCTGCTTCATCCTTTCAACTCGGAGTGGGGG
TGTGGGCGTGAACCTGACAGGAGCAGACACTGTTGTTTTTTATGACAGCGACTGGAATCCCACCATGGATGCTCAGGCCCAGGACCGCTG
TCACCGAATTGGCCAGACCCGGGATGTCCACATATATAGGCTTATCAGTGAACGGACAGTGGAGGAGAACATCCTAAAAAAGGCAAATCA
GAAGAGAATGTTGGGGGACATGGCCATTGAGGGAGGCAACTTCACCACAGCCTATTTCAAACAGCAGACCATCCGAGAGCTGTTTGATAT
GCCCCTGGAGGAACCTTCTAGCTCATCCGTGCCCTCTGCCCCTGAAGAGGAGGAAGAGACTGTGGCCAGCAAGCAGACTCATATTCTGGA
GCAGGCATTGTGTCGGGCAGAAGATGAAGAGGATATCCGTGCAGCCACCCAGGCCAAGGCTGAACAGGTGGCTGAGCTTGCAGAATTTAA
TGAGAACGATGGGTTTCCTGCTGGTGAGGGAGAGGAAGCTGGCCGGCCTGGGGCTGAGGATGAGGAGATGTCCCGGGCTGAGCAGGAAAT
TGCTGCCCTCGTAGAACAGCTGACCCCCATTGAGCGCTATGCCATGAAATTCCTGGAGGCCTCACTGGAGGAGGTGAGCCGAGAGGAGCT
CAAACAGGCAGAAGAGCAAGTGGAAGCTGCCCGCAAAGACCTGGACCAAGCCAAGGAGGAGGTGTTCCGCCTACCCCAAGAGGAGGAGGA
GGGGCCGGGGGCTGGGGATGAGAGTTCCTGTGGGACTGGTGGAGGCACCCACCGGCGCAGTAAAAAGGCCAAAGCCCCTGAGAGGCCGGG
GACTCGTGTCAGTGAGCGTCTTCGTGGAGCCCGGGCTGAGACTCAAGGGGCAAACCACACTCCTGTCATATCCGCCCATCAAACTCGCAG
CACCACCACACCACCCCGCTGCAGTCCTGCCAGGGAGCGAGTTCCCAGGCCAGCACCTAGGCCTCGACCCACTCCAGCTTCAGCTCCGGC
TGCAATTCCTGCCCTTGTTCCTGTCCCAGTTTCTGCCCCAGTACCCATTTCAGCCCCAAATCCAATAACCATTCTCCCTGTCCATATCTT
GCCTTCTCCTCCCCCTCCTTCACAGATTCCTCCTTGTTCTTCTCCTGCCTGCACCCCTCCTCCTGCCTGTACCCCTCCACCAGCTCATAC
ACCGCCTCCAGCCCAAACCTGTCTTGTAACTCCTTCCTCTCCTCTCTTGCTTGGTCCACCTTCTGTGCCCATCTCTGCCTCAGTCACTAA
TCTCCCCTTGGGCTTGAGGCCTGAGGCAGAGCTGTGTGCCCAGGCATTGGCATCTCCAGAGTCCCTGGAGCTGGCTTCTGTGGCCAGTTC
AGAAACCTCCTCACTTTCTCTTGTGCCCCCTAAAGATCTGTTGCCAGTTGCTGTGGAGATCCTGCCTGTGTCAGAGAAGAACCTTTCTCT
CACCCCTTCTGCACCCAGCCTGACCTTGGAGGCTGGCAGCATCCCCAATGGTCAAGAGCAGGAGGCACCAGATTCTGCTGAGGGGACCAC
CCTTACAGTGCTGCCTGAAGGTGAGGAGTTGCCCCTGTGTGTGAGTGAGAGCAATGGCCTGGAGCTCCCACCCTCAGCAGCATCTGATGA
GCCACTTCAGGAGCCACTGGAGGCTGACAGGACCTCGGAAGAGCTGACAGAGGCCAAGACCCCAACCTCCAGCCCAGAGAAGCCACAGGA
ACTCGTTACAGCTGAGGTTGCAGCTCCATCCACCTCATCTTCAGCCACTTCCTCGCCTGAGGGTCCTTCACCTGCCCGACCTCCTCGGCG
TCGCACCAGTGCTGATGTGGAAATTAGGGGTCAAGGGACTGGTCGGCCAGGACAACCACCAGGCCCCAAAGTGCTTCGAAAGCTGCCAGG
ACGGCTGGTAACTGTGGTAGAGGAAAAGGAACTGGTGCGGCGGCGGCGGCAGCAGCGGGGAGCTGCCAGCACCCTAGTGCCTGGGGTCTC
TGAGACTAGTGCCAGCCCGGGAAGCCCGTCTGTCCGCAGCATGTCAGGGCCAGAATCCTCCCCTCCCATTGGTGGGCCCTGTGAAGCTGC
TCCTTCATCCTCACTGCCCACTCCACCCCAGCAGCCCTTCATTGCTCGCCGTCACATTGAGCTGGGGGTGACTGGTGGTGGCAGCCCCGA
GAATGGAGACGGAGCACTGCTCGCCATCACCCCACCTGCTGTGAAACGTCGGAGGGGGAGGCCCCCCAAGAAGAACAGGTCTCCAGCAGA
TGCTGGGAGAGGTGTGGATGAGGCACCCTCATCCACCTTGAAGGGAAAAACCAATGGGGCTGACCCAGTCCCTGGGCCTGAGACCCTAAT
TGTTGCAGATCCTGTCCTGGAACCACAGCTTATTCCTGGGCCCCAGCCTCTTGGACCCCAGCCAGTTCACAGACCCAATCCCCTCCTGTC
ACCTGTGGAGAAAAGAAGGCGAGGACGACCCCCTAAAGCACGAGATTTGCCCATCCCTGGGACCATTTCCTCTGCAGGGGATGGCAACTC
CGAAAGTCGGACACAGCCACCCCCACACCCATCACCCCTAACCCCACTCCCACCACTGCTAGTTTGTCCCACTGCTACTGTTGCCAACAC
TGTCACCACTGTCACCATTTCAACGTCCCCACCCAAACGGAAGAGGGGCCGACCTCCCAAGAATCCTCCATCACCTCGGCCCAGCCAGCT
CCCCGTCTTGGACCGTGACAGCACTTCTGTTCTCGAGAGCTGTGGATTGGGGAGGCGACGGCAACCCCAGGGCCAAGGGGAGAGTGAGGG
TAGTTCCTCTGATGAGGATGGAAGCCGCCCCCTCACCCGCCTGGCCCGCCTTCGGCTTGAAGCAGAAGGAATGCGAGGACGGAAGAGTGG
AGGGTCCATGGTGGTGGCTGTAATTCAGGATGACCTGGACTTAGCAGATAGCGGGCCAGGCGGGTTGGAATTGACACCACCTGTGGTCTC
ACTAACCCCAAAACTGCGCTCGACCCGGCTGCGTCCAGGGTCTCTAGTCCCCCCACTAGAGACTGAGAAGTTGCCTCGCAAACGAGCAGG
GGCCCCAGTTGGTGGGAGTCCTGGGCTGGCAAAGCGGGGCCGCCTACAGCCCCCAAGTCCCCTGGGGCCTGAGGGTTCAGTAGAGGAGTC
TGAGGCTGAAGCCTCAGGTGAGGAGGAGGAAGGGGATGGGACCCCACGCCGACGTCCTGGCCCCCGCCGGCTTGTTGGGACCACCAACCA
AGGGGACCAGCGCATCCTGCGCAGCAGCGCCCCTCCCTCCCTGGCTGGCCCTGCTGTTAGTCACAGAGGCCGCAAGGCCAAGACGTGAGT
GGGCTGCCCCTCCACCTAGGCTTTCCACCGTGGCCACTCCCTCCATGACCAGGCCTGACTCTGTTAACCACTACTTGAAGTCTTGAGGGG
GAAAGCCTCCAGGGAGACATAGGGGCCTTCTCCCTTCTTCCCACCAAAGTAGGGGGTAGGCAACTGGTTGTCATGGAAATGGGGATCATC
ACAGTCCCCTTCCCCTTCACCCCACGTGGCTGGGCAGTGTTAAGGGTGGCAAGATAGTCTCTGTCCCCACCCCCTTGTACTTGATTCCCC
AGCTGTCTTTCACACAGCCCCCCACCCTTAGGGGAAGGGGGAGGGGCTTCTCTACAATGAGGTTTTTTTCTTTTTTTTTTTTTTTTAAGA

>101700_101700_1_ZNF251-SRCAP_ZNF251_chr8_145979068_ENST00000292562_SRCAP_chr16_30740287_ENST00000262518_length(amino acids)=1342AA_BP=548
MEEKRKRQRSERLERIFQLSEAHGALAPVYGTEVLDFCTLPQPVASPIGPRSPGPSHPTFWTYTEAAHRAVLFPQQRLDQLSEIIERFIF
VMPPVEAPPPSLHACHPPPWLAPRQAAFQEQLASELWPRARPLHRIVCNMRTQFPDLRLIQYDCGKLQTLAVLLRQLKAEGHRVLIFTQM
TRMLDVLEQFLTYHGHLYLRLDGSTRVEQRQALMERFNADKRIFCFILSTRSGGVGVNLTGADTVVFYDSDWNPTMDAQAQDRCHRIGQT
RDVHIYRLISERTVEENILKKANQKRMLGDMAIEGGNFTTAYFKQQTIRELFDMPLEEPSSSSVPSAPEEEEETVASKQTHILEQALCRA
EDEEDIRAATQAKAEQVAELAEFNENDGFPAGEGEEAGRPGAEDEEMSRAEQEIAALVEQLTPIERYAMKFLEASLEEVSREELKQAEEQ
VEAARKDLDQAKEEVFRLPQEEEEGPGAGDESSCGTGGGTHRRSKKAKAPERPGTRVSERLRGARAETQGANHTPVISAHQTRSTTTPPR
CSPARERVPRPAPRPRPTPASAPAAIPALVPVPVSAPVPISAPNPITILPVHILPSPPPPSQIPPCSSPACTPPPACTPPPAHTPPPAQT
CLVTPSSPLLLGPPSVPISASVTNLPLGLRPEAELCAQALASPESLELASVASSETSSLSLVPPKDLLPVAVEILPVSEKNLSLTPSAPS
LTLEAGSIPNGQEQEAPDSAEGTTLTVLPEGEELPLCVSESNGLELPPSAASDEPLQEPLEADRTSEELTEAKTPTSSPEKPQELVTAEV
AAPSTSSSATSSPEGPSPARPPRRRTSADVEIRGQGTGRPGQPPGPKVLRKLPGRLVTVVEEKELVRRRRQQRGAASTLVPGVSETSASP
GSPSVRSMSGPESSPPIGGPCEAAPSSSLPTPPQQPFIARRHIELGVTGGGSPENGDGALLAITPPAVKRRRGRPPKKNRSPADAGRGVD
EAPSSTLKGKTNGADPVPGPETLIVADPVLEPQLIPGPQPLGPQPVHRPNPLLSPVEKRRRGRPPKARDLPIPGTISSAGDGNSESRTQP
PPHPSPLTPLPPLLVCPTATVANTVTTVTISTSPPKRKRGRPPKNPPSPRPSQLPVLDRDSTSVLESCGLGRRRQPQGQGESEGSSSDED
GSRPLTRLARLRLEAEGMRGRKSGGSMVVAVIQDDLDLADSGPGGLELTPPVVSLTPKLRSTRLRPGSLVPPLETEKLPRKRAGAPVGGS

--------------------------------------------------------------
>101700_101700_2_ZNF251-SRCAP_ZNF251_chr8_145979068_ENST00000292562_SRCAP_chr16_30740287_ENST00000344771_length(transcript)=4983nt_BP=553nt
GCGTTCTCGGAGGCGTACTGAGGCCCCGCAGGGGGCGGGGAAGCCTGCGTGTGCGCAGCTCGGCCCGGCCCGCCCTCTTCATCCTAGCCC
GCCCCCTCCCCGGCTCTGGACCCGGTTCTGTGGGAGGGTCCGTTCCGGGCTCGGTGCGACTGCGCAGCTCCTCGGCGCTTCCTCGGTGGC
TTCCCCGGGTCGAGCAAACAGGTAAGTTCGGGGAGACTTCAGGCCAGGGCAGTCTCCTGTCTTCTCTTGGAAACCACAGCAGCCCATGCA
CACAGAATGGCAGCCACATTCCAGCTTCCAGGGCACCAGGAGATGCCGCTGACCTTCCAGGATGTGGCCGTGTACTTCTCTCAGGCGGAG
GGGCGGCAGCTGGGCCCCCAGCAGCGGGCGCTCTACCGGGATGTGATGCTGGAGAACTATGGGAACGTGGCCTCTCTGGGATTCCCTGTC
CCTAAGCCGGAGTTGATCTCCCAGCTGGAGCAGGGGAAGGAACTTTGGGTCCTGAATCTTCTGGGAGCTGAGGAACCAGATATCTTGAAA
AGCTGCCAGAAAGGACTCCCTGGAGGAAAAGCGGAAGCGGCAGCGGTCTGAACGCCTGGAACGGATTTTCCAACTTAGTGAGGCTCATGG
GGCCCTGGCACCTGTGTATGGGACTGAAGTCCTGGATTTCTGTACCCTGCCCCAACCTGTTGCCAGCCCCATCGGCCCTCGTTCTCCTGG
CCCCAGCCACCCCACCTTTTGGACTTATACCGAGGCTGCCCACCGGGCTGTACTGTTTCCCCAGCAGCGACTAGACCAGCTGTCAGAAAT
CATTGAGAGGTTCATCTTTGTCATGCCTCCTGTGGAGGCACCTCCCCCTTCCCTGCATGCCTGCCACCCACCTCCTTGGCTGGCCCCACG
TCAGGCAGCCTTCCAGGAGCAATTGGCCTCTGAGCTCTGGCCCCGGGCTCGTCCTTTGCACCGTATTGTGTGTAACATGCGCACCCAGTT
CCCTGACTTAAGACTCATCCAGTATGATTGCGGAAAGTTGCAGACGTTGGCAGTGCTGTTGCGGCAGCTCAAGGCAGAGGGCCACCGAGT
GCTCATCTTCACCCAGATGACCCGAATGCTGGATGTATTGGAGCAGTTTCTCACCTACCATGGCCATCTCTACCTGCGCCTGGATGGATC
TACTAGAGTTGAACAGAGACAGGCCTTGATGGAACGGTTCAATGCAGACAAACGCATATTCTGCTTCATCCTTTCAACTCGGAGTGGGGG
TGTGGGCGTGAACCTGACAGGAGCAGACACTGTTGTTTTTTATGACAGCGACTGGAATCCCACCATGGATGCTCAGGCCCAGGACCGCTG
TCACCGAATTGGCCAGACCCGGGATGTCCACATATATAGGCTTATCAGTGAACGGACAGTGGAGGAGAACATCCTAAAAAAGGCAAATCA
GAAGAGAATGTTGGGGGACATGGCCATTGAGGGAGGCAACTTCACCACAGCCTATTTCAAACAGCAGACCATCCGAGAGCTGTTTGATAT
GCCCCTGGAGGAACCTTCTAGCTCATCCGTGCCCTCTGCCCCTGAAGAGGAGGAAGAGACTGTGGCCAGCAAGCAGACTCATATTCTGGA
GCAGGCATTGTGTCGGGCAGAAGATGAAGAGGATATCCGTGCAGCCACCCAGGCCAAGGCTGAACAGGTGGCTGAGCTTGCAGAATTTAA
TGAGAACGATGGGTTTCCTGCTGGTGAGGGAGAGGAAGCTGGCCGGCCTGGGGCTGAGGATGAGGAGATGTCCCGGGCTGAGCAGGAAAT
TGCTGCCCTCGTAGAACAGCTGACCCCCATTGAGCGCTATGCCATGAAATTCCTGGAGGCCTCACTGGAGGAGGTGAGCCGAGAGGAGCT
CAAACAGGCAGAAGAGCAAGTGGAAGCTGCCCGCAAAGACCTGGACCAAGCCAAGGAGGAGGTGTTCCGCCTACCCCAAGAGGAGGAGGA
GGGGCCGGGGGCTGGGGATGAGAGTTCCTGTGGGACTGGTGGAGGCACCCACCGGCGCAGTAAAAAGGCCAAAGCCCCTGAGAGGCCGGG
GACTCGTGTCAGTGAGCGTCTTCGTGGAGCCCGGGCTGAGACTCAAGGGGCAAACCACACTCCTGTCATATCCGCCCATCAAACTCGCAG
CACCACCACACCACCCCGCTGCAGTCCTGCCAGGGAGCGAGTTCCCAGGCCAGCACCTAGGCCTCGACCCACTCCAGCTTCAGCTCCGGC
TGCAATTCCTGCCCTTGTTCCTGTCCCAGTTTCTGCCCCAGTACCCATTTCAGCCCCAAATCCAATAACCATTCTCCCTGTCCATATCTT
GCCTTCTCCTCCCCCTCCTTCACAGATTCCTCCTTGTTCTTCTCCTGCCTGCACCCCTCCTCCTGCCTGTACCCCTCCACCAGCTCATAC
ACCGCCTCCAGCCCAAACCTGTCTTGTAACTCCTTCCTCTCCTCTCTTGCTTGGTCCACCTTCTGTGCCCATCTCTGCCTCAGTCACTAA
TCTCCCCTTGGGCTTGAGGCCTGAGGCAGAGCTGTGTGCCCAGGCATTGGCATCTCCAGAGTCCCTGGAGCTGGCTTCTGTGGCCAGTTC
AGAAACCTCCTCACTTTCTCTTGTGCCCCCTAAAGATCTGTTGCCAGTTGCTGTGGAGATCCTGCCTGTGTCAGAGAAGAACCTTTCTCT
CACCCCTTCTGCACCCAGCCTGACCTTGGAGGCTGGCAGCATCCCCAATGGTCAAGAGCAGGAGGCACCAGATTCTGCTGAGGGGACCAC
CCTTACAGTGCTGCCTGAAGGTGAGGAGTTGCCCCTGTGTGTGAGTGAGAGCAATGGCCTGGAGCTCCCACCCTCAGCAGCATCTGATGA
GCCACTTCAGGAGCCACTGGAGGCTGACAGGACCTCGGAAGAGCTGACAGAGGCCAAGACCCCAACCTCCAGCCCAGAGAAGCCACAGGA
ACTCGTTACAGCTGAGGTTGCAGCTCCATCCACCTCATCTTCAGCCACTTCCTCGCCTGAGGGTCCTTCACCTGCCCGACCTCCTCGGCG
TCGCACCAGTGCTGATGTGGAAATTAGGGGTCAAGGGACTGGTCGGCCAGGACAACCACCAGGCCCCAAAGTGCTTCGAAAGCTGCCAGG
ACGGCTGGTAACTGTGGTAGAGGAAAAGGAACTGGTGCGGCGGCGGCGGCAGCAGCGGGGAGCTGCCAGCACCCTAGTGCCTGGGGTCTC
TGAGACTAGTGCCAGCCCGGGAAGCCCGTCTGTCCGCAGCATGTCAGGGCCAGAATCCTCCCCTCCCATTGGTGGGCCCTGTGAAGCTGC
TCCTTCATCCTCACTGCCCACTCCACCCCAGCAGCCCTTCATTGCTCGCCGTCACATTGAGCTGGGGGTGACTGGTGGTGGCAGCCCCGA
GAATGGAGACGGAGCACTGCTCGCCATCACCCCACCTGCTGTGAAACGTCGGAGGGGGAGGCCCCCCAAGAAGAACAGGTCTCCAGCAGA
TGCTGGGAGAGGTGTGGATGAGGCACCCTCATCCACCTTGAAGGGAAAAACCAATGGGGCTGACCCAGTCCCTGGGCCTGAGACCCTAAT
TGTTGCAGATCCTGTCCTGGAACCACAGCTTATTCCTGGGCCCCAGCCTCTTGGACCCCAGCCAGTTCACAGACCCAATCCCCTCCTGTC
ACCTGTGGAGAAAAGAAGGCGAGGACGACCCCCTAAAGCACGAGATTTGCCCATCCCTGGGACCATTTCCTCTGCAGGGGATGGCAACTC
CGAAAGTCGGACACAGCCACCCCCACACCCATCACCCCTAACCCCACTCCCACCACTGCTAGTTTGTCCCACTGCTACTGTTGCCAACAC
TGTCACCACTGTCACCATTTCAACGTCCCCACCCAAACGGAAGAGGGGCCGACCTCCCAAGAATCCTCCATCACCTCGGCCCAGCCAGCT
CCCCGTCTTGGACCGTGACAGCACTTCTGTTCTCGAGAGCTGTGGATTGGGGAGGCGACGGCAACCCCAGGGCCAAGGGGAGAGTGAGGG
TAGTTCCTCTGATGAGGATGGAAGCCGCCCCCTCACCCGCCTGGCCCGCCTTCGGCTTGAAGCAGAAGGAATGCGAGGACGGAAGAGTGG
AGGGTCCATGGTGGTGGCTGTAATTCAGGATGACCTGGACTTAGCAGATAGCGGGCCAGGCGGGTTGGAATTGACACCACCTGTGGTCTC
ACTAACCCCAAAACTGCGCTCGACCCGGCTGCGTCCAGGGTCTCTAGTCCCCCCACTAGAGACTGAGAAGTTGCCTCGCAAACGAGCAGG
GGCCCCAGTTGGTGGGAGTCCTGGGCTGGCAAAGCGGGGCCGCCTACAGCCCCCAAGTCCCCTGGGGCCTGAGGGTTCAGTAGAGGAGTC
TGAGGCTGAAGCCTCAGGTGAGGAGGAGGAAGGGGATGGGACCCCACGCCGACGTCCTGGCCCCCGCCGGCTTGTTGGGACCACCAACCA
AGGGGACCAGCGCATCCTGCGCAGCAGCGCCCCTCCCTCCCTGGCTGGCCCTGCTGTTAGTCACAGAGGCCGCAAGGCCAAGACGTGAGT
GGGCTGCCCCTCCACCTAGGCTTTCCACCGTGGCCACTCCCTCCATGACCAGGCCTGACTCTGTTAACCACTACTTGAAGTCTTGAGGGG
GAAAGCCTCCAGGGAGACATAGGGGCCTTCTCCCTTCTTCCCACCAAAGTAGGGGGTAGGCAACTGGTTGTCATGGAAATGGGGATCATC
ACAGTCCCCTTCCCCTTCACCCCACGTGGCTGGGCAGTGTTAAGGGTGGCAAGATAGTCTCTGTCCCCACCCCCTTGTACTTGATTCCCC
AGCTGTCTTTCACACAGCCCCCCACCCTTAGGGGAAGGGGGAGGGGCTTCTCTACAATGAGGTTTTTTTCTTTTTTTTTTTTTTTTAAGA

>101700_101700_2_ZNF251-SRCAP_ZNF251_chr8_145979068_ENST00000292562_SRCAP_chr16_30740287_ENST00000344771_length(amino acids)=1342AA_BP=548
MEEKRKRQRSERLERIFQLSEAHGALAPVYGTEVLDFCTLPQPVASPIGPRSPGPSHPTFWTYTEAAHRAVLFPQQRLDQLSEIIERFIF
VMPPVEAPPPSLHACHPPPWLAPRQAAFQEQLASELWPRARPLHRIVCNMRTQFPDLRLIQYDCGKLQTLAVLLRQLKAEGHRVLIFTQM
TRMLDVLEQFLTYHGHLYLRLDGSTRVEQRQALMERFNADKRIFCFILSTRSGGVGVNLTGADTVVFYDSDWNPTMDAQAQDRCHRIGQT
RDVHIYRLISERTVEENILKKANQKRMLGDMAIEGGNFTTAYFKQQTIRELFDMPLEEPSSSSVPSAPEEEEETVASKQTHILEQALCRA
EDEEDIRAATQAKAEQVAELAEFNENDGFPAGEGEEAGRPGAEDEEMSRAEQEIAALVEQLTPIERYAMKFLEASLEEVSREELKQAEEQ
VEAARKDLDQAKEEVFRLPQEEEEGPGAGDESSCGTGGGTHRRSKKAKAPERPGTRVSERLRGARAETQGANHTPVISAHQTRSTTTPPR
CSPARERVPRPAPRPRPTPASAPAAIPALVPVPVSAPVPISAPNPITILPVHILPSPPPPSQIPPCSSPACTPPPACTPPPAHTPPPAQT
CLVTPSSPLLLGPPSVPISASVTNLPLGLRPEAELCAQALASPESLELASVASSETSSLSLVPPKDLLPVAVEILPVSEKNLSLTPSAPS
LTLEAGSIPNGQEQEAPDSAEGTTLTVLPEGEELPLCVSESNGLELPPSAASDEPLQEPLEADRTSEELTEAKTPTSSPEKPQELVTAEV
AAPSTSSSATSSPEGPSPARPPRRRTSADVEIRGQGTGRPGQPPGPKVLRKLPGRLVTVVEEKELVRRRRQQRGAASTLVPGVSETSASP
GSPSVRSMSGPESSPPIGGPCEAAPSSSLPTPPQQPFIARRHIELGVTGGGSPENGDGALLAITPPAVKRRRGRPPKKNRSPADAGRGVD
EAPSSTLKGKTNGADPVPGPETLIVADPVLEPQLIPGPQPLGPQPVHRPNPLLSPVEKRRRGRPPKARDLPIPGTISSAGDGNSESRTQP
PPHPSPLTPLPPLLVCPTATVANTVTTVTISTSPPKRKRGRPPKNPPSPRPSQLPVLDRDSTSVLESCGLGRRRQPQGQGESEGSSSDED
GSRPLTRLARLRLEAEGMRGRKSGGSMVVAVIQDDLDLADSGPGGLELTPPVVSLTPKLRSTRLRPGSLVPPLETEKLPRKRAGAPVGGS

--------------------------------------------------------------
>101700_101700_3_ZNF251-SRCAP_ZNF251_chr8_145979068_ENST00000292562_SRCAP_chr16_30740287_ENST00000395059_length(transcript)=4983nt_BP=553nt
GCGTTCTCGGAGGCGTACTGAGGCCCCGCAGGGGGCGGGGAAGCCTGCGTGTGCGCAGCTCGGCCCGGCCCGCCCTCTTCATCCTAGCCC
GCCCCCTCCCCGGCTCTGGACCCGGTTCTGTGGGAGGGTCCGTTCCGGGCTCGGTGCGACTGCGCAGCTCCTCGGCGCTTCCTCGGTGGC
TTCCCCGGGTCGAGCAAACAGGTAAGTTCGGGGAGACTTCAGGCCAGGGCAGTCTCCTGTCTTCTCTTGGAAACCACAGCAGCCCATGCA
CACAGAATGGCAGCCACATTCCAGCTTCCAGGGCACCAGGAGATGCCGCTGACCTTCCAGGATGTGGCCGTGTACTTCTCTCAGGCGGAG
GGGCGGCAGCTGGGCCCCCAGCAGCGGGCGCTCTACCGGGATGTGATGCTGGAGAACTATGGGAACGTGGCCTCTCTGGGATTCCCTGTC
CCTAAGCCGGAGTTGATCTCCCAGCTGGAGCAGGGGAAGGAACTTTGGGTCCTGAATCTTCTGGGAGCTGAGGAACCAGATATCTTGAAA
AGCTGCCAGAAAGGACTCCCTGGAGGAAAAGCGGAAGCGGCAGCGGTCTGAACGCCTGGAACGGATTTTCCAACTTAGTGAGGCTCATGG
GGCCCTGGCACCTGTGTATGGGACTGAAGTCCTGGATTTCTGTACCCTGCCCCAACCTGTTGCCAGCCCCATCGGCCCTCGTTCTCCTGG
CCCCAGCCACCCCACCTTTTGGACTTATACCGAGGCTGCCCACCGGGCTGTACTGTTTCCCCAGCAGCGACTAGACCAGCTGTCAGAAAT
CATTGAGAGGTTCATCTTTGTCATGCCTCCTGTGGAGGCACCTCCCCCTTCCCTGCATGCCTGCCACCCACCTCCTTGGCTGGCCCCACG
TCAGGCAGCCTTCCAGGAGCAATTGGCCTCTGAGCTCTGGCCCCGGGCTCGTCCTTTGCACCGTATTGTGTGTAACATGCGCACCCAGTT
CCCTGACTTAAGACTCATCCAGTATGATTGCGGAAAGTTGCAGACGTTGGCAGTGCTGTTGCGGCAGCTCAAGGCAGAGGGCCACCGAGT
GCTCATCTTCACCCAGATGACCCGAATGCTGGATGTATTGGAGCAGTTTCTCACCTACCATGGCCATCTCTACCTGCGCCTGGATGGATC
TACTAGAGTTGAACAGAGACAGGCCTTGATGGAACGGTTCAATGCAGACAAACGCATATTCTGCTTCATCCTTTCAACTCGGAGTGGGGG
TGTGGGCGTGAACCTGACAGGAGCAGACACTGTTGTTTTTTATGACAGCGACTGGAATCCCACCATGGATGCTCAGGCCCAGGACCGCTG
TCACCGAATTGGCCAGACCCGGGATGTCCACATATATAGGCTTATCAGTGAACGGACAGTGGAGGAGAACATCCTAAAAAAGGCAAATCA
GAAGAGAATGTTGGGGGACATGGCCATTGAGGGAGGCAACTTCACCACAGCCTATTTCAAACAGCAGACCATCCGAGAGCTGTTTGATAT
GCCCCTGGAGGAACCTTCTAGCTCATCCGTGCCCTCTGCCCCTGAAGAGGAGGAAGAGACTGTGGCCAGCAAGCAGACTCATATTCTGGA
GCAGGCATTGTGTCGGGCAGAAGATGAAGAGGATATCCGTGCAGCCACCCAGGCCAAGGCTGAACAGGTGGCTGAGCTTGCAGAATTTAA
TGAGAACGATGGGTTTCCTGCTGGTGAGGGAGAGGAAGCTGGCCGGCCTGGGGCTGAGGATGAGGAGATGTCCCGGGCTGAGCAGGAAAT
TGCTGCCCTCGTAGAACAGCTGACCCCCATTGAGCGCTATGCCATGAAATTCCTGGAGGCCTCACTGGAGGAGGTGAGCCGAGAGGAGCT
CAAACAGGCAGAAGAGCAAGTGGAAGCTGCCCGCAAAGACCTGGACCAAGCCAAGGAGGAGGTGTTCCGCCTACCCCAAGAGGAGGAGGA
GGGGCCGGGGGCTGGGGATGAGAGTTCCTGTGGGACTGGTGGAGGCACCCACCGGCGCAGTAAAAAGGCCAAAGCCCCTGAGAGGCCGGG
GACTCGTGTCAGTGAGCGTCTTCGTGGAGCCCGGGCTGAGACTCAAGGGGCAAACCACACTCCTGTCATATCCGCCCATCAAACTCGCAG
CACCACCACACCACCCCGCTGCAGTCCTGCCAGGGAGCGAGTTCCCAGGCCAGCACCTAGGCCTCGACCCACTCCAGCTTCAGCTCCGGC
TGCAATTCCTGCCCTTGTTCCTGTCCCAGTTTCTGCCCCAGTACCCATTTCAGCCCCAAATCCAATAACCATTCTCCCTGTCCATATCTT
GCCTTCTCCTCCCCCTCCTTCACAGATTCCTCCTTGTTCTTCTCCTGCCTGCACCCCTCCTCCTGCCTGTACCCCTCCACCAGCTCATAC
ACCGCCTCCAGCCCAAACCTGTCTTGTAACTCCTTCCTCTCCTCTCTTGCTTGGTCCACCTTCTGTGCCCATCTCTGCCTCAGTCACTAA
TCTCCCCTTGGGCTTGAGGCCTGAGGCAGAGCTGTGTGCCCAGGCATTGGCATCTCCAGAGTCCCTGGAGCTGGCTTCTGTGGCCAGTTC
AGAAACCTCCTCACTTTCTCTTGTGCCCCCTAAAGATCTGTTGCCAGTTGCTGTGGAGATCCTGCCTGTGTCAGAGAAGAACCTTTCTCT
CACCCCTTCTGCACCCAGCCTGACCTTGGAGGCTGGCAGCATCCCCAATGGTCAAGAGCAGGAGGCACCAGATTCTGCTGAGGGGACCAC
CCTTACAGTGCTGCCTGAAGGTGAGGAGTTGCCCCTGTGTGTGAGTGAGAGCAATGGCCTGGAGCTCCCACCCTCAGCAGCATCTGATGA
GCCACTTCAGGAGCCACTGGAGGCTGACAGGACCTCGGAAGAGCTGACAGAGGCCAAGACCCCAACCTCCAGCCCAGAGAAGCCACAGGA
ACTCGTTACAGCTGAGGTTGCAGCTCCATCCACCTCATCTTCAGCCACTTCCTCGCCTGAGGGTCCTTCACCTGCCCGACCTCCTCGGCG
TCGCACCAGTGCTGATGTGGAAATTAGGGGTCAAGGGACTGGTCGGCCAGGACAACCACCAGGCCCCAAAGTGCTTCGAAAGCTGCCAGG
ACGGCTGGTAACTGTGGTAGAGGAAAAGGAACTGGTGCGGCGGCGGCGGCAGCAGCGGGGAGCTGCCAGCACCCTAGTGCCTGGGGTCTC
TGAGACTAGTGCCAGCCCGGGAAGCCCGTCTGTCCGCAGCATGTCAGGGCCAGAATCCTCCCCTCCCATTGGTGGGCCCTGTGAAGCTGC
TCCTTCATCCTCACTGCCCACTCCACCCCAGCAGCCCTTCATTGCTCGCCGTCACATTGAGCTGGGGGTGACTGGTGGTGGCAGCCCCGA
GAATGGAGACGGAGCACTGCTCGCCATCACCCCACCTGCTGTGAAACGTCGGAGGGGGAGGCCCCCCAAGAAGAACAGGTCTCCAGCAGA
TGCTGGGAGAGGTGTGGATGAGGCACCCTCATCCACCTTGAAGGGAAAAACCAATGGGGCTGACCCAGTCCCTGGGCCTGAGACCCTAAT
TGTTGCAGATCCTGTCCTGGAACCACAGCTTATTCCTGGGCCCCAGCCTCTTGGACCCCAGCCAGTTCACAGACCCAATCCCCTCCTGTC
ACCTGTGGAGAAAAGAAGGCGAGGACGACCCCCTAAAGCACGAGATTTGCCCATCCCTGGGACCATTTCCTCTGCAGGGGATGGCAACTC
CGAAAGTCGGACACAGCCACCCCCACACCCATCACCCCTAACCCCACTCCCACCACTGCTAGTTTGTCCCACTGCTACTGTTGCCAACAC
TGTCACCACTGTCACCATTTCAACGTCCCCACCCAAACGGAAGAGGGGCCGACCTCCCAAGAATCCTCCATCACCTCGGCCCAGCCAGCT
CCCCGTCTTGGACCGTGACAGCACTTCTGTTCTCGAGAGCTGTGGATTGGGGAGGCGACGGCAACCCCAGGGCCAAGGGGAGAGTGAGGG
TAGTTCCTCTGATGAGGATGGAAGCCGCCCCCTCACCCGCCTGGCCCGCCTTCGGCTTGAAGCAGAAGGAATGCGAGGACGGAAGAGTGG
AGGGTCCATGGTGGTGGCTGTAATTCAGGATGACCTGGACTTAGCAGATAGCGGGCCAGGCGGGTTGGAATTGACACCACCTGTGGTCTC
ACTAACCCCAAAACTGCGCTCGACCCGGCTGCGTCCAGGGTCTCTAGTCCCCCCACTAGAGACTGAGAAGTTGCCTCGCAAACGAGCAGG
GGCCCCAGTTGGTGGGAGTCCTGGGCTGGCAAAGCGGGGCCGCCTACAGCCCCCAAGTCCCCTGGGGCCTGAGGGTTCAGTAGAGGAGTC
TGAGGCTGAAGCCTCAGGTGAGGAGGAGGAAGGGGATGGGACCCCACGCCGACGTCCTGGCCCCCGCCGGCTTGTTGGGACCACCAACCA
AGGGGACCAGCGCATCCTGCGCAGCAGCGCCCCTCCCTCCCTGGCTGGCCCTGCTGTTAGTCACAGAGGCCGCAAGGCCAAGACGTGAGT
GGGCTGCCCCTCCACCTAGGCTTTCCACCGTGGCCACTCCCTCCATGACCAGGCCTGACTCTGTTAACCACTACTTGAAGTCTTGAGGGG
GAAAGCCTCCAGGGAGACATAGGGGCCTTCTCCCTTCTTCCCACCAAAGTAGGGGGTAGGCAACTGGTTGTCATGGAAATGGGGATCATC
ACAGTCCCCTTCCCCTTCACCCCACGTGGCTGGGCAGTGTTAAGGGTGGCAAGATAGTCTCTGTCCCCACCCCCTTGTACTTGATTCCCC
AGCTGTCTTTCACACAGCCCCCCACCCTTAGGGGAAGGGGGAGGGGCTTCTCTACAATGAGGTTTTTTTCTTTTTTTTTTTTTTTTAAGA

>101700_101700_3_ZNF251-SRCAP_ZNF251_chr8_145979068_ENST00000292562_SRCAP_chr16_30740287_ENST00000395059_length(amino acids)=1342AA_BP=548
MEEKRKRQRSERLERIFQLSEAHGALAPVYGTEVLDFCTLPQPVASPIGPRSPGPSHPTFWTYTEAAHRAVLFPQQRLDQLSEIIERFIF
VMPPVEAPPPSLHACHPPPWLAPRQAAFQEQLASELWPRARPLHRIVCNMRTQFPDLRLIQYDCGKLQTLAVLLRQLKAEGHRVLIFTQM
TRMLDVLEQFLTYHGHLYLRLDGSTRVEQRQALMERFNADKRIFCFILSTRSGGVGVNLTGADTVVFYDSDWNPTMDAQAQDRCHRIGQT
RDVHIYRLISERTVEENILKKANQKRMLGDMAIEGGNFTTAYFKQQTIRELFDMPLEEPSSSSVPSAPEEEEETVASKQTHILEQALCRA
EDEEDIRAATQAKAEQVAELAEFNENDGFPAGEGEEAGRPGAEDEEMSRAEQEIAALVEQLTPIERYAMKFLEASLEEVSREELKQAEEQ
VEAARKDLDQAKEEVFRLPQEEEEGPGAGDESSCGTGGGTHRRSKKAKAPERPGTRVSERLRGARAETQGANHTPVISAHQTRSTTTPPR
CSPARERVPRPAPRPRPTPASAPAAIPALVPVPVSAPVPISAPNPITILPVHILPSPPPPSQIPPCSSPACTPPPACTPPPAHTPPPAQT
CLVTPSSPLLLGPPSVPISASVTNLPLGLRPEAELCAQALASPESLELASVASSETSSLSLVPPKDLLPVAVEILPVSEKNLSLTPSAPS
LTLEAGSIPNGQEQEAPDSAEGTTLTVLPEGEELPLCVSESNGLELPPSAASDEPLQEPLEADRTSEELTEAKTPTSSPEKPQELVTAEV
AAPSTSSSATSSPEGPSPARPPRRRTSADVEIRGQGTGRPGQPPGPKVLRKLPGRLVTVVEEKELVRRRRQQRGAASTLVPGVSETSASP
GSPSVRSMSGPESSPPIGGPCEAAPSSSLPTPPQQPFIARRHIELGVTGGGSPENGDGALLAITPPAVKRRRGRPPKKNRSPADAGRGVD
EAPSSTLKGKTNGADPVPGPETLIVADPVLEPQLIPGPQPLGPQPVHRPNPLLSPVEKRRRGRPPKARDLPIPGTISSAGDGNSESRTQP
PPHPSPLTPLPPLLVCPTATVANTVTTVTISTSPPKRKRGRPPKNPPSPRPSQLPVLDRDSTSVLESCGLGRRRQPQGQGESEGSSSDED
GSRPLTRLARLRLEAEGMRGRKSGGSMVVAVIQDDLDLADSGPGGLELTPPVVSLTPKLRSTRLRPGSLVPPLETEKLPRKRAGAPVGGS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ZNF251-SRCAP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ZNF251-SRCAP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ZNF251-SRCAP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource