FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ZNF264-TRAP1 (FusionGDB2 ID:101731)

Fusion Gene Summary for ZNF264-TRAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF264-TRAP1
Fusion gene ID: 101731
HgeneTgene
Gene symbol

ZNF264

TRAP1

Gene ID

114026

10131

Gene namezinc finger imprinted 3TNF receptor associated protein 1
SynonymsZNF264|ZNF657HSP 75|HSP75|HSP90L|TRAP-1
Cytomap

19q13.43

16p13.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger imprinted 3Zinc finger protein 264zinc finger protein 657heat shock protein 75 kDa, mitochondrialTNFR-associated protein 1testicular tissue protein Li 209tumor necrosis factor type 1 receptor-associated protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000263095, ENST00000536056, 
ENST00000599653, ENST00000600531, 
ENST00000538171, ENST00000575671, 
ENST00000573872, ENST00000246957, 
Fusion gene scores* DoF score2 X 2 X 2=87 X 10 X 7=490
# samples 212
** MAII scorelog2(2/8*10)=1.32192809488736log2(12/490*10)=-2.02974734339405
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF264 [Title/Abstract] AND TRAP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF264(57703314)-TRAP1(3727659), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ZNF264 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TRAP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer161NZNF264chr19

57703314

+TRAP1chr16

3727659

-


Top

Fusion Gene ORF analysis for ZNF264-TRAP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000263095ENST00000538171ZNF264chr19

57703314

+TRAP1chr16

3727659

-
5CDS-5UTRENST00000263095ENST00000575671ZNF264chr19

57703314

+TRAP1chr16

3727659

-
5CDS-5UTRENST00000536056ENST00000538171ZNF264chr19

57703314

+TRAP1chr16

3727659

-
5CDS-5UTRENST00000536056ENST00000575671ZNF264chr19

57703314

+TRAP1chr16

3727659

-
5CDS-5UTRENST00000599653ENST00000538171ZNF264chr19

57703314

+TRAP1chr16

3727659

-
5CDS-5UTRENST00000599653ENST00000575671ZNF264chr19

57703314

+TRAP1chr16

3727659

-
5CDS-5UTRENST00000600531ENST00000538171ZNF264chr19

57703314

+TRAP1chr16

3727659

-
5CDS-5UTRENST00000600531ENST00000575671ZNF264chr19

57703314

+TRAP1chr16

3727659

-
5CDS-intronENST00000263095ENST00000573872ZNF264chr19

57703314

+TRAP1chr16

3727659

-
5CDS-intronENST00000536056ENST00000573872ZNF264chr19

57703314

+TRAP1chr16

3727659

-
5CDS-intronENST00000599653ENST00000573872ZNF264chr19

57703314

+TRAP1chr16

3727659

-
5CDS-intronENST00000600531ENST00000573872ZNF264chr19

57703314

+TRAP1chr16

3727659

-
In-frameENST00000263095ENST00000246957ZNF264chr19

57703314

+TRAP1chr16

3727659

-
In-frameENST00000536056ENST00000246957ZNF264chr19

57703314

+TRAP1chr16

3727659

-
In-frameENST00000599653ENST00000246957ZNF264chr19

57703314

+TRAP1chr16

3727659

-
In-frameENST00000600531ENST00000246957ZNF264chr19

57703314

+TRAP1chr16

3727659

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000263095ZNF264chr1957703314+ENST00000246957TRAP1chr163727659-21114471712018615
ENST00000600531ZNF264chr1957703314+ENST00000246957TRAP1chr163727659-21104461702017615
ENST00000599653ZNF264chr1957703314+ENST00000246957TRAP1chr163727659-20744101341981615
ENST00000536056ZNF264chr1957703314+ENST00000246957TRAP1chr163727659-175389231660545

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000263095ENST00000246957ZNF264chr1957703314+TRAP1chr163727659-0.0122484280.9877516
ENST00000600531ENST00000246957ZNF264chr1957703314+TRAP1chr163727659-0.0122408490.9877592
ENST00000599653ENST00000246957ZNF264chr1957703314+TRAP1chr163727659-0.0130180280.98698205
ENST00000536056ENST00000246957ZNF264chr1957703314+TRAP1chr163727659-0.0156866780.98431337

Top

Fusion Genomic Features for ZNF264-TRAP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for ZNF264-TRAP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:57703314/chr16:3727659)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF264chr19:57703314chr16:3727659ENST00000263095+1414_8511628.0DomainKRAB
HgeneZNF264chr19:57703314chr16:3727659ENST00000536056+2514_8511628.0DomainKRAB
HgeneZNF264chr19:57703314chr16:3727659ENST00000263095+14203_22511628.0Zinc fingerC2H2-type 1
HgeneZNF264chr19:57703314chr16:3727659ENST00000263095+14231_25311628.0Zinc fingerC2H2-type 2
HgeneZNF264chr19:57703314chr16:3727659ENST00000263095+14259_28111628.0Zinc fingerC2H2-type 3
HgeneZNF264chr19:57703314chr16:3727659ENST00000263095+14287_30911628.0Zinc fingerC2H2-type 4
HgeneZNF264chr19:57703314chr16:3727659ENST00000263095+14315_33711628.0Zinc fingerC2H2-type 5
HgeneZNF264chr19:57703314chr16:3727659ENST00000263095+14343_36511628.0Zinc fingerC2H2-type 6
HgeneZNF264chr19:57703314chr16:3727659ENST00000263095+14371_39311628.0Zinc fingerC2H2-type 7
HgeneZNF264chr19:57703314chr16:3727659ENST00000263095+14399_42111628.0Zinc fingerC2H2-type 8
HgeneZNF264chr19:57703314chr16:3727659ENST00000263095+14427_44911628.0Zinc fingerC2H2-type 9
HgeneZNF264chr19:57703314chr16:3727659ENST00000263095+14455_47711628.0Zinc fingerC2H2-type 10
HgeneZNF264chr19:57703314chr16:3727659ENST00000263095+14483_50511628.0Zinc fingerC2H2-type 11
HgeneZNF264chr19:57703314chr16:3727659ENST00000263095+14511_53311628.0Zinc fingerC2H2-type 12
HgeneZNF264chr19:57703314chr16:3727659ENST00000263095+14539_56111628.0Zinc fingerC2H2-type 13
HgeneZNF264chr19:57703314chr16:3727659ENST00000536056+25203_22511628.0Zinc fingerC2H2-type 1
HgeneZNF264chr19:57703314chr16:3727659ENST00000536056+25231_25311628.0Zinc fingerC2H2-type 2
HgeneZNF264chr19:57703314chr16:3727659ENST00000536056+25259_28111628.0Zinc fingerC2H2-type 3
HgeneZNF264chr19:57703314chr16:3727659ENST00000536056+25287_30911628.0Zinc fingerC2H2-type 4
HgeneZNF264chr19:57703314chr16:3727659ENST00000536056+25315_33711628.0Zinc fingerC2H2-type 5
HgeneZNF264chr19:57703314chr16:3727659ENST00000536056+25343_36511628.0Zinc fingerC2H2-type 6
HgeneZNF264chr19:57703314chr16:3727659ENST00000536056+25371_39311628.0Zinc fingerC2H2-type 7
HgeneZNF264chr19:57703314chr16:3727659ENST00000536056+25399_42111628.0Zinc fingerC2H2-type 8
HgeneZNF264chr19:57703314chr16:3727659ENST00000536056+25427_44911628.0Zinc fingerC2H2-type 9
HgeneZNF264chr19:57703314chr16:3727659ENST00000536056+25455_47711628.0Zinc fingerC2H2-type 10
HgeneZNF264chr19:57703314chr16:3727659ENST00000536056+25483_50511628.0Zinc fingerC2H2-type 11
HgeneZNF264chr19:57703314chr16:3727659ENST00000536056+25511_53311628.0Zinc fingerC2H2-type 12
HgeneZNF264chr19:57703314chr16:3727659ENST00000536056+25539_56111628.0Zinc fingerC2H2-type 13


Top

Fusion Gene Sequence for ZNF264-TRAP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>101731_101731_1_ZNF264-TRAP1_ZNF264_chr19_57703314_ENST00000263095_TRAP1_chr16_3727659_ENST00000246957_length(transcript)=2111nt_BP=447nt
ATTTTCTTCTGCACTTCTGTCTGGAGAGGTCTGTAGCCACTGAGGGCCCCGGTCGGGGCCGCTTTGCAGGTCCCTAGTCAGGACCGAGCA
GGGGAGTAGGATAGGAATCCCCGCCGCACCTTTGTACGAGCCTGACCCCTTCCGTGGGTTTGTTCCTGGGTCGCCGTCAAGCTGCGGTCT
CTCCTCCCCCGCCCTTCAGCCCCGCGGTCTCCAGGGGCGGCGCCCTGGGTCTGGAACGCGGTTGCCACCGAGGAGGCGGCGGCCCTGCGT
CTGGAACGCCGTTGCCACCGAGGAGGCGGCGGCCCCGAGCGCGCCTGGAAGCCCCGGGCAACCGGCCAGGGTCGGGCACAGGTGGGGTCC
GTCAGGCCGCCCGGGGCTCCTCTGTCCCAGCTCTGCGGCCCAGGGGGTGACGTGATGGCGGCAGCGGTGCTGACGGACCGGGCCCAGGCC
TTCCTGGATGCTCTGCAGAACCAGGCTGAGGCCAGCAGCAAGATCATCGGCCAGTTTGGAGTGGGTTTCTACTCAGCTTTCATGGTGGCT
GACAGAGTGGAGGTCTATTCCCGCTCGGCAGCCCCGGGGAGCCTGGGTTACCAGTGGCTTTCAGATGGTTCTGGAGTGTTTGAAATCGCC
GAAGCTTCGGGAGTTAGAACCGGGACAAAAATCATCATCCACCTGAAATCCGACTGCAAGGAGTTTTCCAGCGAGGCCCGGGTGCGAGAT
GTGGTAACGAAGTACAGCAACTTCGTCAGCTTCCCCTTGTACTTGAATGGAAGGCGGATGAACACCTTGCAGGCCATCTGGATGATGGAC
CCCAAGGATGTCCGTGAGTGGCAACATGAGGAGTTCTACCGCTACGTCGCGCAGGCTCACGACAAGCCCCGCTACACCCTGCACTATAAG
ACGGACGCACCGCTCAACATCCGCAGCATCTTCTACGTGCCCGACATGAAACCGTCCATGTTTGATGTGAGCCGGGAGCTGGGCTCCAGC
GTTGCACTGTACAGCCGCAAAGTCCTCATCCAGACCAAGGCCACGGACATCCTGCCCAAGTGGCTGCGCTTCATCCGAGGTGTGGTGGAC
AGTGAGGACATTCCCCTGAACCTCAGCCGGGAGCTGCTGCAGGAGAGCGCACTCATCAGGAAACTCCGGGACGTTTTACAGCAGAGGCTG
ATCAAATTCTTCATTGACCAGAGTAAAAAAGATGCTGAGAAGTATGCAAAGTTTTTTGAAGATTACGGCCTGTTCATGCGGGAGGGCATT
GTGACCGCCACCGAGCAGGAGGTCAAGGAGGACATAGCAAAGCTGCTGCGCTACGAGTCCTCGGCGCTGCCCTCCGGGCAGCTAACCAGC
CTCTCAGAATACGCCAGCCGCATGCGGGCCGGCACCCGCAACATCTACTACCTGTGCGCCCCCAACCGTCACCTGGCAGAGCACTCACCC
TACTATGAGGCCATGAAGAAGAAAGACACAGAGGTTCTCTTCTGCTTTGAGCAGTTTGATGAGCTCACCCTGCTGCACCTTCGTGAGTTT
GACAAGAAGAAGCTGATCTCTGTGGAGACGGACATAGTCGTGGATCACTACAAGGAGGAGAAGTTTGAGGACAGGTCCCCAGCCGCCGAG
TGCCTATCAGAGAAGGAGACGGAGGAGCTCATGGCCTGGATGAGAAATGTGCTGGGGTCGCGTGTCACCAACGTGAAGGTGACCCTCCGA
CTGGACACCCACCCTGCCATGGTCACCGTGCTGGAGATGGGGGCTGCCCGCCACTTCCTGCGCATGCAGCAGCTGGCCAAGACCCAGGAG
GAGCGCGCACAGCTCCTGCAGCCCACGCTGGAGATCAACCCCAGGCACGCGCTCATCAAGAAGCTGAATCAGCTGCGCGCAAGCGAGCCT
GGCCTGGCTCAGCTGCTGGTGGATCAGATATACGAGAACGCCATGATTGCTGCTGGACTTGTTGACGACCCTAGGGCCATGGTGGGCCGC
TTGAATGAGCTGCTTGTCAAGGCCCTGGAGCGACACTGACAGCCAGGGGGCCAGAAGGACTGACACCACAGATGACAGCCCCACCTCCTT

>101731_101731_1_ZNF264-TRAP1_ZNF264_chr19_57703314_ENST00000263095_TRAP1_chr16_3727659_ENST00000246957_length(amino acids)=615AA_BP=84
MRSLLPRPSAPRSPGAAPWVWNAVATEEAAALRLERRCHRGGGGPERAWKPRATGQGRAQVGSVRPPGAPLSQLCGPGGDVMAAAVLTDR
AQAFLDALQNQAEASSKIIGQFGVGFYSAFMVADRVEVYSRSAAPGSLGYQWLSDGSGVFEIAEASGVRTGTKIIIHLKSDCKEFSSEAR
VRDVVTKYSNFVSFPLYLNGRRMNTLQAIWMMDPKDVREWQHEEFYRYVAQAHDKPRYTLHYKTDAPLNIRSIFYVPDMKPSMFDVSREL
GSSVALYSRKVLIQTKATDILPKWLRFIRGVVDSEDIPLNLSRELLQESALIRKLRDVLQQRLIKFFIDQSKKDAEKYAKFFEDYGLFMR
EGIVTATEQEVKEDIAKLLRYESSALPSGQLTSLSEYASRMRAGTRNIYYLCAPNRHLAEHSPYYEAMKKKDTEVLFCFEQFDELTLLHL
REFDKKKLISVETDIVVDHYKEEKFEDRSPAAECLSEKETEELMAWMRNVLGSRVTNVKVTLRLDTHPAMVTVLEMGAARHFLRMQQLAK

--------------------------------------------------------------
>101731_101731_2_ZNF264-TRAP1_ZNF264_chr19_57703314_ENST00000536056_TRAP1_chr16_3727659_ENST00000246957_length(transcript)=1753nt_BP=89nt
ACGCCGTTGCCACCGAGGCTCCTCTGTCCCAGCTCTGCGGCCCAGGGGGTGACGTGATGGCGGCAGCGGTGCTGACGGACCGGGCCCAGG
CCTTCCTGGATGCTCTGCAGAACCAGGCTGAGGCCAGCAGCAAGATCATCGGCCAGTTTGGAGTGGGTTTCTACTCAGCTTTCATGGTGG
CTGACAGAGTGGAGGTCTATTCCCGCTCGGCAGCCCCGGGGAGCCTGGGTTACCAGTGGCTTTCAGATGGTTCTGGAGTGTTTGAAATCG
CCGAAGCTTCGGGAGTTAGAACCGGGACAAAAATCATCATCCACCTGAAATCCGACTGCAAGGAGTTTTCCAGCGAGGCCCGGGTGCGAG
ATGTGGTAACGAAGTACAGCAACTTCGTCAGCTTCCCCTTGTACTTGAATGGAAGGCGGATGAACACCTTGCAGGCCATCTGGATGATGG
ACCCCAAGGATGTCCGTGAGTGGCAACATGAGGAGTTCTACCGCTACGTCGCGCAGGCTCACGACAAGCCCCGCTACACCCTGCACTATA
AGACGGACGCACCGCTCAACATCCGCAGCATCTTCTACGTGCCCGACATGAAACCGTCCATGTTTGATGTGAGCCGGGAGCTGGGCTCCA
GCGTTGCACTGTACAGCCGCAAAGTCCTCATCCAGACCAAGGCCACGGACATCCTGCCCAAGTGGCTGCGCTTCATCCGAGGTGTGGTGG
ACAGTGAGGACATTCCCCTGAACCTCAGCCGGGAGCTGCTGCAGGAGAGCGCACTCATCAGGAAACTCCGGGACGTTTTACAGCAGAGGC
TGATCAAATTCTTCATTGACCAGAGTAAAAAAGATGCTGAGAAGTATGCAAAGTTTTTTGAAGATTACGGCCTGTTCATGCGGGAGGGCA
TTGTGACCGCCACCGAGCAGGAGGTCAAGGAGGACATAGCAAAGCTGCTGCGCTACGAGTCCTCGGCGCTGCCCTCCGGGCAGCTAACCA
GCCTCTCAGAATACGCCAGCCGCATGCGGGCCGGCACCCGCAACATCTACTACCTGTGCGCCCCCAACCGTCACCTGGCAGAGCACTCAC
CCTACTATGAGGCCATGAAGAAGAAAGACACAGAGGTTCTCTTCTGCTTTGAGCAGTTTGATGAGCTCACCCTGCTGCACCTTCGTGAGT
TTGACAAGAAGAAGCTGATCTCTGTGGAGACGGACATAGTCGTGGATCACTACAAGGAGGAGAAGTTTGAGGACAGGTCCCCAGCCGCCG
AGTGCCTATCAGAGAAGGAGACGGAGGAGCTCATGGCCTGGATGAGAAATGTGCTGGGGTCGCGTGTCACCAACGTGAAGGTGACCCTCC
GACTGGACACCCACCCTGCCATGGTCACCGTGCTGGAGATGGGGGCTGCCCGCCACTTCCTGCGCATGCAGCAGCTGGCCAAGACCCAGG
AGGAGCGCGCACAGCTCCTGCAGCCCACGCTGGAGATCAACCCCAGGCACGCGCTCATCAAGAAGCTGAATCAGCTGCGCGCAAGCGAGC
CTGGCCTGGCTCAGCTGCTGGTGGATCAGATATACGAGAACGCCATGATTGCTGCTGGACTTGTTGACGACCCTAGGGCCATGGTGGGCC
GCTTGAATGAGCTGCTTGTCAAGGCCCTGGAGCGACACTGACAGCCAGGGGGCCAGAAGGACTGACACCACAGATGACAGCCCCACCTCC

>101731_101731_2_ZNF264-TRAP1_ZNF264_chr19_57703314_ENST00000536056_TRAP1_chr16_3727659_ENST00000246957_length(amino acids)=545AA_BP=14
MSQLCGPGGDVMAAAVLTDRAQAFLDALQNQAEASSKIIGQFGVGFYSAFMVADRVEVYSRSAAPGSLGYQWLSDGSGVFEIAEASGVRT
GTKIIIHLKSDCKEFSSEARVRDVVTKYSNFVSFPLYLNGRRMNTLQAIWMMDPKDVREWQHEEFYRYVAQAHDKPRYTLHYKTDAPLNI
RSIFYVPDMKPSMFDVSRELGSSVALYSRKVLIQTKATDILPKWLRFIRGVVDSEDIPLNLSRELLQESALIRKLRDVLQQRLIKFFIDQ
SKKDAEKYAKFFEDYGLFMREGIVTATEQEVKEDIAKLLRYESSALPSGQLTSLSEYASRMRAGTRNIYYLCAPNRHLAEHSPYYEAMKK
KDTEVLFCFEQFDELTLLHLREFDKKKLISVETDIVVDHYKEEKFEDRSPAAECLSEKETEELMAWMRNVLGSRVTNVKVTLRLDTHPAM
VTVLEMGAARHFLRMQQLAKTQEERAQLLQPTLEINPRHALIKKLNQLRASEPGLAQLLVDQIYENAMIAAGLVDDPRAMVGRLNELLVK

--------------------------------------------------------------
>101731_101731_3_ZNF264-TRAP1_ZNF264_chr19_57703314_ENST00000599653_TRAP1_chr16_3727659_ENST00000246957_length(transcript)=2074nt_BP=410nt
CACTGAGGGCCCCGGTCGGGGCCGCTTTGCAGGTCCCTAGTCAGGACCGAGCAGGGGAGTAGGATAGGAATCCCCGCCGCACCTTTGTAC
GAGCCTGACCCCTTCCGTGGGTTTGTTCCTGGGTCGCCGTCAAGCTGCGGTCTCTCCTCCCCCGCCCTTCAGCCCCGCGGTCTCCAGGGG
CGGCGCCCTGGGTCTGGAACGCGGTTGCCACCGAGGAGGCGGCGGCCCTGCGTCTGGAACGCCGTTGCCACCGAGGAGGCGGCGGCCCCG
AGCGCGCCTGGAAGCCCCGGGCAACCGGCCAGGGTCGGGCACAGGTGGGGTCCGTCAGGCCGCCCGGGGCTCCTCTGTCCCAGCTCTGCG
GCCCAGGGGGTGACGTGATGGCGGCAGCGGTGCTGACGGACCGGGCCCAGGCCTTCCTGGATGCTCTGCAGAACCAGGCTGAGGCCAGCA
GCAAGATCATCGGCCAGTTTGGAGTGGGTTTCTACTCAGCTTTCATGGTGGCTGACAGAGTGGAGGTCTATTCCCGCTCGGCAGCCCCGG
GGAGCCTGGGTTACCAGTGGCTTTCAGATGGTTCTGGAGTGTTTGAAATCGCCGAAGCTTCGGGAGTTAGAACCGGGACAAAAATCATCA
TCCACCTGAAATCCGACTGCAAGGAGTTTTCCAGCGAGGCCCGGGTGCGAGATGTGGTAACGAAGTACAGCAACTTCGTCAGCTTCCCCT
TGTACTTGAATGGAAGGCGGATGAACACCTTGCAGGCCATCTGGATGATGGACCCCAAGGATGTCCGTGAGTGGCAACATGAGGAGTTCT
ACCGCTACGTCGCGCAGGCTCACGACAAGCCCCGCTACACCCTGCACTATAAGACGGACGCACCGCTCAACATCCGCAGCATCTTCTACG
TGCCCGACATGAAACCGTCCATGTTTGATGTGAGCCGGGAGCTGGGCTCCAGCGTTGCACTGTACAGCCGCAAAGTCCTCATCCAGACCA
AGGCCACGGACATCCTGCCCAAGTGGCTGCGCTTCATCCGAGGTGTGGTGGACAGTGAGGACATTCCCCTGAACCTCAGCCGGGAGCTGC
TGCAGGAGAGCGCACTCATCAGGAAACTCCGGGACGTTTTACAGCAGAGGCTGATCAAATTCTTCATTGACCAGAGTAAAAAAGATGCTG
AGAAGTATGCAAAGTTTTTTGAAGATTACGGCCTGTTCATGCGGGAGGGCATTGTGACCGCCACCGAGCAGGAGGTCAAGGAGGACATAG
CAAAGCTGCTGCGCTACGAGTCCTCGGCGCTGCCCTCCGGGCAGCTAACCAGCCTCTCAGAATACGCCAGCCGCATGCGGGCCGGCACCC
GCAACATCTACTACCTGTGCGCCCCCAACCGTCACCTGGCAGAGCACTCACCCTACTATGAGGCCATGAAGAAGAAAGACACAGAGGTTC
TCTTCTGCTTTGAGCAGTTTGATGAGCTCACCCTGCTGCACCTTCGTGAGTTTGACAAGAAGAAGCTGATCTCTGTGGAGACGGACATAG
TCGTGGATCACTACAAGGAGGAGAAGTTTGAGGACAGGTCCCCAGCCGCCGAGTGCCTATCAGAGAAGGAGACGGAGGAGCTCATGGCCT
GGATGAGAAATGTGCTGGGGTCGCGTGTCACCAACGTGAAGGTGACCCTCCGACTGGACACCCACCCTGCCATGGTCACCGTGCTGGAGA
TGGGGGCTGCCCGCCACTTCCTGCGCATGCAGCAGCTGGCCAAGACCCAGGAGGAGCGCGCACAGCTCCTGCAGCCCACGCTGGAGATCA
ACCCCAGGCACGCGCTCATCAAGAAGCTGAATCAGCTGCGCGCAAGCGAGCCTGGCCTGGCTCAGCTGCTGGTGGATCAGATATACGAGA
ACGCCATGATTGCTGCTGGACTTGTTGACGACCCTAGGGCCATGGTGGGCCGCTTGAATGAGCTGCTTGTCAAGGCCCTGGAGCGACACT
GACAGCCAGGGGGCCAGAAGGACTGACACCACAGATGACAGCCCCACCTCCTTGAGCTTTATTTACCTAAATTTAAAGGTATTTCTTAAC

>101731_101731_3_ZNF264-TRAP1_ZNF264_chr19_57703314_ENST00000599653_TRAP1_chr16_3727659_ENST00000246957_length(amino acids)=615AA_BP=84
MRSLLPRPSAPRSPGAAPWVWNAVATEEAAALRLERRCHRGGGGPERAWKPRATGQGRAQVGSVRPPGAPLSQLCGPGGDVMAAAVLTDR
AQAFLDALQNQAEASSKIIGQFGVGFYSAFMVADRVEVYSRSAAPGSLGYQWLSDGSGVFEIAEASGVRTGTKIIIHLKSDCKEFSSEAR
VRDVVTKYSNFVSFPLYLNGRRMNTLQAIWMMDPKDVREWQHEEFYRYVAQAHDKPRYTLHYKTDAPLNIRSIFYVPDMKPSMFDVSREL
GSSVALYSRKVLIQTKATDILPKWLRFIRGVVDSEDIPLNLSRELLQESALIRKLRDVLQQRLIKFFIDQSKKDAEKYAKFFEDYGLFMR
EGIVTATEQEVKEDIAKLLRYESSALPSGQLTSLSEYASRMRAGTRNIYYLCAPNRHLAEHSPYYEAMKKKDTEVLFCFEQFDELTLLHL
REFDKKKLISVETDIVVDHYKEEKFEDRSPAAECLSEKETEELMAWMRNVLGSRVTNVKVTLRLDTHPAMVTVLEMGAARHFLRMQQLAK

--------------------------------------------------------------
>101731_101731_4_ZNF264-TRAP1_ZNF264_chr19_57703314_ENST00000600531_TRAP1_chr16_3727659_ENST00000246957_length(transcript)=2110nt_BP=446nt
TTTTCTTCTGCACTTCTGTCTGGAGAGGTCTGTAGCCACTGAGGGCCCCGGTCGGGGCCGCTTTGCAGGTCCCTAGTCAGGACCGAGCAG
GGGAGTAGGATAGGAATCCCCGCCGCACCTTTGTACGAGCCTGACCCCTTCCGTGGGTTTGTTCCTGGGTCGCCGTCAAGCTGCGGTCTC
TCCTCCCCCGCCCTTCAGCCCCGCGGTCTCCAGGGGCGGCGCCCTGGGTCTGGAACGCGGTTGCCACCGAGGAGGCGGCGGCCCTGCGTC
TGGAACGCCGTTGCCACCGAGGAGGCGGCGGCCCCGAGCGCGCCTGGAAGCCCCGGGCAACCGGCCAGGGTCGGGCACAGGTGGGGTCCG
TCAGGCCGCCCGGGGCTCCTCTGTCCCAGCTCTGCGGCCCAGGGGGTGACGTGATGGCGGCAGCGGTGCTGACGGACCGGGCCCAGGCCT
TCCTGGATGCTCTGCAGAACCAGGCTGAGGCCAGCAGCAAGATCATCGGCCAGTTTGGAGTGGGTTTCTACTCAGCTTTCATGGTGGCTG
ACAGAGTGGAGGTCTATTCCCGCTCGGCAGCCCCGGGGAGCCTGGGTTACCAGTGGCTTTCAGATGGTTCTGGAGTGTTTGAAATCGCCG
AAGCTTCGGGAGTTAGAACCGGGACAAAAATCATCATCCACCTGAAATCCGACTGCAAGGAGTTTTCCAGCGAGGCCCGGGTGCGAGATG
TGGTAACGAAGTACAGCAACTTCGTCAGCTTCCCCTTGTACTTGAATGGAAGGCGGATGAACACCTTGCAGGCCATCTGGATGATGGACC
CCAAGGATGTCCGTGAGTGGCAACATGAGGAGTTCTACCGCTACGTCGCGCAGGCTCACGACAAGCCCCGCTACACCCTGCACTATAAGA
CGGACGCACCGCTCAACATCCGCAGCATCTTCTACGTGCCCGACATGAAACCGTCCATGTTTGATGTGAGCCGGGAGCTGGGCTCCAGCG
TTGCACTGTACAGCCGCAAAGTCCTCATCCAGACCAAGGCCACGGACATCCTGCCCAAGTGGCTGCGCTTCATCCGAGGTGTGGTGGACA
GTGAGGACATTCCCCTGAACCTCAGCCGGGAGCTGCTGCAGGAGAGCGCACTCATCAGGAAACTCCGGGACGTTTTACAGCAGAGGCTGA
TCAAATTCTTCATTGACCAGAGTAAAAAAGATGCTGAGAAGTATGCAAAGTTTTTTGAAGATTACGGCCTGTTCATGCGGGAGGGCATTG
TGACCGCCACCGAGCAGGAGGTCAAGGAGGACATAGCAAAGCTGCTGCGCTACGAGTCCTCGGCGCTGCCCTCCGGGCAGCTAACCAGCC
TCTCAGAATACGCCAGCCGCATGCGGGCCGGCACCCGCAACATCTACTACCTGTGCGCCCCCAACCGTCACCTGGCAGAGCACTCACCCT
ACTATGAGGCCATGAAGAAGAAAGACACAGAGGTTCTCTTCTGCTTTGAGCAGTTTGATGAGCTCACCCTGCTGCACCTTCGTGAGTTTG
ACAAGAAGAAGCTGATCTCTGTGGAGACGGACATAGTCGTGGATCACTACAAGGAGGAGAAGTTTGAGGACAGGTCCCCAGCCGCCGAGT
GCCTATCAGAGAAGGAGACGGAGGAGCTCATGGCCTGGATGAGAAATGTGCTGGGGTCGCGTGTCACCAACGTGAAGGTGACCCTCCGAC
TGGACACCCACCCTGCCATGGTCACCGTGCTGGAGATGGGGGCTGCCCGCCACTTCCTGCGCATGCAGCAGCTGGCCAAGACCCAGGAGG
AGCGCGCACAGCTCCTGCAGCCCACGCTGGAGATCAACCCCAGGCACGCGCTCATCAAGAAGCTGAATCAGCTGCGCGCAAGCGAGCCTG
GCCTGGCTCAGCTGCTGGTGGATCAGATATACGAGAACGCCATGATTGCTGCTGGACTTGTTGACGACCCTAGGGCCATGGTGGGCCGCT
TGAATGAGCTGCTTGTCAAGGCCCTGGAGCGACACTGACAGCCAGGGGGCCAGAAGGACTGACACCACAGATGACAGCCCCACCTCCTTG

>101731_101731_4_ZNF264-TRAP1_ZNF264_chr19_57703314_ENST00000600531_TRAP1_chr16_3727659_ENST00000246957_length(amino acids)=615AA_BP=84
MRSLLPRPSAPRSPGAAPWVWNAVATEEAAALRLERRCHRGGGGPERAWKPRATGQGRAQVGSVRPPGAPLSQLCGPGGDVMAAAVLTDR
AQAFLDALQNQAEASSKIIGQFGVGFYSAFMVADRVEVYSRSAAPGSLGYQWLSDGSGVFEIAEASGVRTGTKIIIHLKSDCKEFSSEAR
VRDVVTKYSNFVSFPLYLNGRRMNTLQAIWMMDPKDVREWQHEEFYRYVAQAHDKPRYTLHYKTDAPLNIRSIFYVPDMKPSMFDVSREL
GSSVALYSRKVLIQTKATDILPKWLRFIRGVVDSEDIPLNLSRELLQESALIRKLRDVLQQRLIKFFIDQSKKDAEKYAKFFEDYGLFMR
EGIVTATEQEVKEDIAKLLRYESSALPSGQLTSLSEYASRMRAGTRNIYYLCAPNRHLAEHSPYYEAMKKKDTEVLFCFEQFDELTLLHL
REFDKKKLISVETDIVVDHYKEEKFEDRSPAAECLSEKETEELMAWMRNVLGSRVTNVKVTLRLDTHPAMVTVLEMGAARHFLRMQQLAK

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ZNF264-TRAP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ZNF264-TRAP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ZNF264-TRAP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource