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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF268-TRPM3 (FusionGDB2 ID:101745)

Fusion Gene Summary for ZNF268-TRPM3

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF268-TRPM3
Fusion gene ID: 101745
HgeneTgene
Gene symbol

ZNF268

TRPM3

Gene ID

10795

80036

Gene namezinc finger protein 268transient receptor potential cation channel subfamily M member 3
SynonymsHZF3GON-2|LTRPC3|MLSN2
Cytomap

12q24.33

9q21.12-q21.13

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 268zinc finger protein 3zinc finger protein HZF3transient receptor potential cation channel subfamily M member 3long transient receptor potential channel 3melastatin-2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000228289, ENST00000416488, 
ENST00000536435, ENST00000536899, 
ENST00000539248, ENST00000541009, 
ENST00000541211, ENST00000542711, 
ENST00000542986, ENST00000592241, 
ENST00000537565, 		ENST00000361823, 
ENST00000377097, ENST00000377101, 
ENST00000396283, ENST00000437699, 
ENST00000357533, ENST00000358082, 
ENST00000360823, ENST00000377105, 
ENST00000377106, ENST00000377110, 
ENST00000377111, ENST00000396280, 
ENST00000396285, ENST00000396292, 
ENST00000408909, ENST00000423814, 
Fusion gene scores* DoF score7 X 4 X 6=16810 X 10 X 3=300
# samples 710
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/300*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF268 [Title/Abstract] AND TRPM3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF268(133758616)-TRPM3(73255576), # samples:1
Anticipated loss of major functional domain due to fusion event.ZNF268-TRPM3 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ZNF268-TRPM3 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZNF268

GO:0000122

negative regulation of transcription by RNA polymerase II

12822888

TgeneTRPM3

GO:0006812

cation transport

15824111


check buttonFusion gene breakpoints across ZNF268 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TRPM3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-RP-A694-06AZNF268chr12

133758616

+TRPM3chr9

73255576

-


Top

Fusion Gene ORF analysis for ZNF268-TRPM3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000228289ENST00000361823ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000228289ENST00000377097ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000228289ENST00000377101ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000228289ENST00000396283ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000228289ENST00000437699ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000416488ENST00000361823ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000416488ENST00000377097ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000416488ENST00000377101ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000416488ENST00000396283ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000416488ENST00000437699ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000536435ENST00000361823ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000536435ENST00000377097ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000536435ENST00000377101ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000536435ENST00000396283ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000536435ENST00000437699ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000536899ENST00000361823ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000536899ENST00000377097ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000536899ENST00000377101ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000536899ENST00000396283ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000536899ENST00000437699ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000539248ENST00000361823ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000539248ENST00000377097ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000539248ENST00000377101ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000539248ENST00000396283ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000539248ENST00000437699ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000541009ENST00000361823ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000541009ENST00000377097ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000541009ENST00000377101ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000541009ENST00000396283ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000541009ENST00000437699ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000541211ENST00000361823ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000541211ENST00000377097ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000541211ENST00000377101ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000541211ENST00000396283ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000541211ENST00000437699ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000542711ENST00000361823ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000542711ENST00000377097ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000542711ENST00000377101ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000542711ENST00000396283ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000542711ENST00000437699ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000542986ENST00000361823ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000542986ENST00000377097ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000542986ENST00000377101ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000542986ENST00000396283ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000542986ENST00000437699ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000592241ENST00000361823ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000592241ENST00000377097ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000592241ENST00000377101ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000592241ENST00000396283ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5CDS-intronENST00000592241ENST00000437699ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5UTR-3CDSENST00000537565ENST00000357533ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5UTR-3CDSENST00000537565ENST00000358082ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5UTR-3CDSENST00000537565ENST00000360823ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5UTR-3CDSENST00000537565ENST00000377105ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5UTR-3CDSENST00000537565ENST00000377106ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5UTR-3CDSENST00000537565ENST00000377110ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5UTR-3CDSENST00000537565ENST00000377111ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5UTR-3CDSENST00000537565ENST00000396280ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5UTR-3CDSENST00000537565ENST00000396285ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5UTR-3CDSENST00000537565ENST00000396292ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5UTR-3CDSENST00000537565ENST00000408909ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5UTR-3CDSENST00000537565ENST00000423814ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5UTR-intronENST00000537565ENST00000361823ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5UTR-intronENST00000537565ENST00000377097ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5UTR-intronENST00000537565ENST00000377101ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5UTR-intronENST00000537565ENST00000396283ZNF268chr12

133758616

+TRPM3chr9

73255576

-
5UTR-intronENST00000537565ENST00000437699ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000228289ENST00000357533ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000228289ENST00000358082ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000228289ENST00000360823ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000228289ENST00000377105ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000228289ENST00000377106ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000228289ENST00000377110ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000228289ENST00000377111ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000228289ENST00000396280ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000228289ENST00000396285ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000228289ENST00000396292ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000228289ENST00000408909ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000228289ENST00000423814ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000416488ENST00000357533ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000416488ENST00000358082ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000416488ENST00000360823ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000416488ENST00000377105ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000416488ENST00000377106ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000416488ENST00000377110ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000416488ENST00000377111ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000416488ENST00000396280ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000416488ENST00000396285ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000416488ENST00000396292ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000416488ENST00000408909ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000416488ENST00000423814ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000536435ENST00000357533ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000536435ENST00000358082ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000536435ENST00000360823ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000536435ENST00000377105ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000536435ENST00000377106ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000536435ENST00000377110ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000536435ENST00000377111ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000536435ENST00000396280ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000536435ENST00000396285ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000536435ENST00000396292ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000536435ENST00000408909ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000536435ENST00000423814ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000536899ENST00000357533ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000536899ENST00000358082ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000536899ENST00000360823ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000536899ENST00000377105ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000536899ENST00000377106ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000536899ENST00000377110ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000536899ENST00000377111ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000536899ENST00000396280ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000536899ENST00000396285ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000536899ENST00000396292ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000536899ENST00000408909ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000536899ENST00000423814ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000539248ENST00000357533ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000539248ENST00000358082ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000539248ENST00000360823ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000539248ENST00000377105ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000539248ENST00000377106ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000539248ENST00000377110ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000539248ENST00000377111ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000539248ENST00000396280ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000539248ENST00000396285ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000539248ENST00000396292ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000539248ENST00000408909ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000539248ENST00000423814ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000541009ENST00000357533ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000541009ENST00000358082ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000541009ENST00000360823ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000541009ENST00000377105ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000541009ENST00000377106ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000541009ENST00000377110ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000541009ENST00000377111ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000541009ENST00000396280ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000541009ENST00000396285ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000541009ENST00000396292ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000541009ENST00000408909ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000541009ENST00000423814ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000541211ENST00000357533ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000541211ENST00000358082ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000541211ENST00000360823ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000541211ENST00000377105ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000541211ENST00000377106ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000541211ENST00000377110ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000541211ENST00000377111ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000541211ENST00000396280ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000541211ENST00000396285ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000541211ENST00000396292ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000541211ENST00000408909ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000541211ENST00000423814ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000542711ENST00000357533ZNF268chr12

133758616

+TRPM3chr9

73255576

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Frame-shiftENST00000542711ENST00000358082ZNF268chr12

133758616

+TRPM3chr9

73255576

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Frame-shiftENST00000542711ENST00000360823ZNF268chr12

133758616

+TRPM3chr9

73255576

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Frame-shiftENST00000542711ENST00000377105ZNF268chr12

133758616

+TRPM3chr9

73255576

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Frame-shiftENST00000542711ENST00000377106ZNF268chr12

133758616

+TRPM3chr9

73255576

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Frame-shiftENST00000542711ENST00000377110ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000542711ENST00000377111ZNF268chr12

133758616

+TRPM3chr9

73255576

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Frame-shiftENST00000542711ENST00000396280ZNF268chr12

133758616

+TRPM3chr9

73255576

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Frame-shiftENST00000542711ENST00000396285ZNF268chr12

133758616

+TRPM3chr9

73255576

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Frame-shiftENST00000542711ENST00000396292ZNF268chr12

133758616

+TRPM3chr9

73255576

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Frame-shiftENST00000542711ENST00000408909ZNF268chr12

133758616

+TRPM3chr9

73255576

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Frame-shiftENST00000542711ENST00000423814ZNF268chr12

133758616

+TRPM3chr9

73255576

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Frame-shiftENST00000542986ENST00000357533ZNF268chr12

133758616

+TRPM3chr9

73255576

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Frame-shiftENST00000542986ENST00000358082ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000542986ENST00000360823ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000542986ENST00000377105ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000542986ENST00000377106ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000542986ENST00000377110ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000542986ENST00000377111ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000542986ENST00000396280ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000542986ENST00000396285ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000542986ENST00000396292ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000542986ENST00000408909ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000542986ENST00000423814ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000592241ENST00000357533ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000592241ENST00000358082ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000592241ENST00000360823ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000592241ENST00000377105ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000592241ENST00000377106ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000592241ENST00000377110ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000592241ENST00000377111ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000592241ENST00000396280ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000592241ENST00000396285ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000592241ENST00000396292ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000592241ENST00000408909ZNF268chr12

133758616

+TRPM3chr9

73255576

-
Frame-shiftENST00000592241ENST00000423814ZNF268chr12

133758616

+TRPM3chr9

73255576

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ZNF268-TRPM3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF268-TRPM3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:133758616/:73255576)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ZNF268-TRPM3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ZNF268-TRPM3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF268-TRPM3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF268-TRPM3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource