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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BRD2-GUSB (FusionGDB2 ID:10175)

Fusion Gene Summary for BRD2-GUSB

check button Fusion gene summary
Fusion gene informationFusion gene name: BRD2-GUSB
Fusion gene ID: 10175
HgeneTgene
Gene symbol

BRD2

GUSB

Gene ID

6046

2990

Gene namebromodomain containing 2glucuronidase beta
SynonymsBRD2-IT1|D6S113E|FSH|FSRG1|NAT|O27.1.1|RING3|RNF3BG|MPS7
Cytomap

6p21.32

7q11.21

Type of geneprotein-codingprotein-coding
Descriptionbromodomain-containing protein 2BRD2 intronic transcript 1female sterile homeotic-related gene 1really interesting new gene 3 proteinbeta-glucuronidasebeta-D-glucuronidasebeta-G1
Modification date2020031320200313
UniProtAcc

P25440

Q6P575

Ensembl transtripts involved in fusion geneENST00000580234, ENST00000374825, 
ENST00000374831, ENST00000383108, 
ENST00000395287, ENST00000395289, 
ENST00000399527, ENST00000399528, 
ENST00000399529, ENST00000414731, 
ENST00000425201, ENST00000436979, 
ENST00000438194, ENST00000442219, 
ENST00000442863, ENST00000443797, 
ENST00000448067, ENST00000449085, 
ENST00000449118, ENST00000450320, 
ENST00000466208, ENST00000466744, 
ENST00000479973, ENST00000482105, 
ENST00000488549, ENST00000496118, 
ENST00000498329, ENST00000546777, 
ENST00000547286, ENST00000547895, 
ENST00000548837, ENST00000549126, 
ENST00000549236, ENST00000549843, 
ENST00000550142, ENST00000550598, 
ENST00000552513, ENST00000552587, 
ENST00000553146, 		ENST00000304895, 
ENST00000345660, ENST00000421103, 
ENST00000476486, 
Fusion gene scores* DoF score6 X 10 X 2=1206 X 4 X 4=96
# samples 107
** MAII scorelog2(10/120*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/96*10)=-0.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BRD2 [Title/Abstract] AND GUSB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBRD2(32938210)-GUSB(65432894), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBRD2

GO:0006357

regulation of transcription by RNA polymerase II

18406326


check buttonFusion gene breakpoints across BRD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GUSB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4PD-01ABRD2chr6

32938210

+GUSBchr7

65432894

-


Top

Fusion Gene ORF analysis for BRD2-GUSB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000580234ENST00000304895BRD2chr6

32938210

+GUSBchr7

65432894

-
3UTR-3CDSENST00000580234ENST00000345660BRD2chr6

32938210

+GUSBchr7

65432894

-
3UTR-3CDSENST00000580234ENST00000421103BRD2chr6

32938210

+GUSBchr7

65432894

-
3UTR-intronENST00000580234ENST00000476486BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000374825ENST00000304895BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000374825ENST00000345660BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000374825ENST00000421103BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000374831ENST00000304895BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000374831ENST00000345660BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000374831ENST00000421103BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000383108ENST00000304895BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000383108ENST00000345660BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000383108ENST00000421103BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000395287ENST00000304895BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000395287ENST00000345660BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000395287ENST00000421103BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000395289ENST00000304895BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000395289ENST00000345660BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000395289ENST00000421103BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000399527ENST00000304895BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000399527ENST00000345660BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000399527ENST00000421103BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000399528ENST00000304895BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000399528ENST00000345660BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000399528ENST00000421103BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000399529ENST00000304895BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000399529ENST00000345660BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000399529ENST00000421103BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000414731ENST00000304895BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000414731ENST00000345660BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000414731ENST00000421103BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000425201ENST00000304895BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000425201ENST00000345660BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000425201ENST00000421103BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000436979ENST00000304895BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000436979ENST00000345660BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000436979ENST00000421103BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000438194ENST00000304895BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000438194ENST00000345660BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000438194ENST00000421103BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000442219ENST00000304895BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000442219ENST00000345660BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000442219ENST00000421103BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000442863ENST00000304895BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000442863ENST00000345660BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000442863ENST00000421103BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000443797ENST00000304895BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000443797ENST00000345660BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000443797ENST00000421103BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000448067ENST00000304895BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000448067ENST00000345660BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000448067ENST00000421103BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000449085ENST00000304895BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000449085ENST00000345660BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000449085ENST00000421103BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000449118ENST00000304895BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000449118ENST00000345660BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000449118ENST00000421103BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000450320ENST00000304895BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000450320ENST00000345660BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000450320ENST00000421103BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000466208ENST00000304895BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000466208ENST00000345660BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000466208ENST00000421103BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000466744ENST00000304895BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000466744ENST00000345660BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000466744ENST00000421103BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000479973ENST00000304895BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000479973ENST00000345660BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000479973ENST00000421103BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000482105ENST00000304895BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000482105ENST00000345660BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000482105ENST00000421103BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000488549ENST00000304895BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000488549ENST00000345660BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000488549ENST00000421103BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000496118ENST00000304895BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000496118ENST00000345660BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000496118ENST00000421103BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000498329ENST00000304895BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000498329ENST00000345660BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000498329ENST00000421103BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000546777ENST00000304895BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000546777ENST00000345660BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000546777ENST00000421103BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000547286ENST00000304895BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000547286ENST00000345660BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000547286ENST00000421103BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000547895ENST00000304895BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000547895ENST00000345660BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000547895ENST00000421103BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000548837ENST00000304895BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000548837ENST00000345660BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000548837ENST00000421103BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000549126ENST00000304895BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000549126ENST00000345660BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000549126ENST00000421103BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000549236ENST00000304895BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000549236ENST00000345660BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000549236ENST00000421103BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000549843ENST00000304895BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000549843ENST00000345660BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000549843ENST00000421103BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000550142ENST00000304895BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000550142ENST00000345660BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000550142ENST00000421103BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000550598ENST00000304895BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000550598ENST00000345660BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000550598ENST00000421103BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000552513ENST00000304895BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000552513ENST00000345660BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000552513ENST00000421103BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000552587ENST00000304895BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000552587ENST00000345660BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000552587ENST00000421103BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000553146ENST00000304895BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000553146ENST00000345660BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-3CDSENST00000553146ENST00000421103BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-intronENST00000374825ENST00000476486BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-intronENST00000374831ENST00000476486BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-intronENST00000383108ENST00000476486BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-intronENST00000395287ENST00000476486BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-intronENST00000395289ENST00000476486BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-intronENST00000399527ENST00000476486BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-intronENST00000399528ENST00000476486BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-intronENST00000399529ENST00000476486BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-intronENST00000414731ENST00000476486BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-intronENST00000425201ENST00000476486BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-intronENST00000436979ENST00000476486BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-intronENST00000438194ENST00000476486BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-intronENST00000442219ENST00000476486BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-intronENST00000442863ENST00000476486BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-intronENST00000443797ENST00000476486BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-intronENST00000448067ENST00000476486BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-intronENST00000449085ENST00000476486BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-intronENST00000449118ENST00000476486BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-intronENST00000450320ENST00000476486BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-intronENST00000466208ENST00000476486BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-intronENST00000466744ENST00000476486BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-intronENST00000479973ENST00000476486BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-intronENST00000482105ENST00000476486BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-intronENST00000488549ENST00000476486BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-intronENST00000496118ENST00000476486BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-intronENST00000498329ENST00000476486BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-intronENST00000546777ENST00000476486BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-intronENST00000547286ENST00000476486BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-intronENST00000547895ENST00000476486BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-intronENST00000548837ENST00000476486BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-intronENST00000549126ENST00000476486BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-intronENST00000549236ENST00000476486BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-intronENST00000549843ENST00000476486BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-intronENST00000550142ENST00000476486BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-intronENST00000550598ENST00000476486BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-intronENST00000552513ENST00000476486BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-intronENST00000552587ENST00000476486BRD2chr6

32938210

+GUSBchr7

65432894

-
intron-intronENST00000553146ENST00000476486BRD2chr6

32938210

+GUSBchr7

65432894

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for BRD2-GUSB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for BRD2-GUSB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:32938210/:65432894)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BRD2

P25440

GUSB

Q6P575

FUNCTION: May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly. {ECO:0000250, ECO:0000269|PubMed:18406326}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for BRD2-GUSB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for BRD2-GUSB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BRD2-GUSB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BRD2-GUSB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource