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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF274-UBA7 (FusionGDB2 ID:101756)

Fusion Gene Summary for ZNF274-UBA7

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF274-UBA7
Fusion gene ID: 101756
HgeneTgene
Gene symbol

ZNF274

UBA7

Gene ID

10782

7318

Gene namezinc finger protein 274ubiquitin like modifier activating enzyme 7
SynonymsHFB101|ZF2|ZKSCAN19|ZSCAN51D8|UBA1B|UBE1L|UBE2
Cytomap

19q13.43

3p21.31

Type of geneprotein-codingprotein-coding
Descriptionneurotrophin receptor-interacting factor homologKRAB zinc finger protein HFB101zinc finger protein HFB101zinc finger protein with KRAB and SCAN domains 19zinc finger protein zfp2ubiquitin-like modifier-activating enzyme 7UBA1, ubiquitin-activating enzyme E1 homolog BUBA7, ubiquitin-activating enzyme E1ubiquitin-activating enzyme 7ubiquitin-activating enzyme E1 homologubiquitin-activating enzyme E1-related proteinubiquitin-a
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000597818, ENST00000326804, 
ENST00000345813, ENST00000424679, 
ENST00000333486, ENST00000494212, 
Fusion gene scores* DoF score5 X 4 X 3=606 X 9 X 5=270
# samples 58
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/270*10)=-1.75488750216347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF274 [Title/Abstract] AND UBA7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF274(58695365)-UBA7(49846592), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneUBA7

GO:0006464

cellular protein modification process

16428300

TgeneUBA7

GO:0032020

ISG15-protein conjugation

16428300


check buttonFusion gene breakpoints across ZNF274 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across UBA7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-D7-A6F0ZNF274chr19

58695365

+UBA7chr3

49846592

-


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Fusion Gene ORF analysis for ZNF274-UBA7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000597818ENST00000333486ZNF274chr19

58695365

+UBA7chr3

49846592

-
3UTR-intronENST00000597818ENST00000494212ZNF274chr19

58695365

+UBA7chr3

49846592

-
5CDS-intronENST00000326804ENST00000494212ZNF274chr19

58695365

+UBA7chr3

49846592

-
5CDS-intronENST00000345813ENST00000494212ZNF274chr19

58695365

+UBA7chr3

49846592

-
In-frameENST00000326804ENST00000333486ZNF274chr19

58695365

+UBA7chr3

49846592

-
In-frameENST00000345813ENST00000333486ZNF274chr19

58695365

+UBA7chr3

49846592

-
intron-3CDSENST00000424679ENST00000333486ZNF274chr19

58695365

+UBA7chr3

49846592

-
intron-intronENST00000424679ENST00000494212ZNF274chr19

58695365

+UBA7chr3

49846592

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000345813ZNF274chr1958695365+ENST00000333486UBA7chr349846592-14694923361367343
ENST00000326804ZNF274chr1958695365+ENST00000333486UBA7chr349846592-14694923361367343

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000345813ENST00000333486ZNF274chr1958695365+UBA7chr349846592-0.0140613930.9859386
ENST00000326804ENST00000333486ZNF274chr1958695365+UBA7chr349846592-0.0140613930.9859386

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Fusion Genomic Features for ZNF274-UBA7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF274-UBA7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:58695365/chr3:49846592)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF274chr19:58695365chr3:49846592ENST00000326804+2914_8511653.0DomainKRAB 1
HgeneZNF274chr19:58695365chr3:49846592ENST00000326804+29161_24311653.0DomainSCAN box
HgeneZNF274chr19:58695365chr3:49846592ENST00000326804+29287_36011653.0DomainKRAB 2
HgeneZNF274chr19:58695365chr3:49846592ENST00000345813+2814_8511621.0DomainKRAB 1
HgeneZNF274chr19:58695365chr3:49846592ENST00000345813+28161_24311621.0DomainSCAN box
HgeneZNF274chr19:58695365chr3:49846592ENST00000345813+28287_36011621.0DomainKRAB 2
HgeneZNF274chr19:58695365chr3:49846592ENST00000424679+1614_850548.0DomainKRAB 1
HgeneZNF274chr19:58695365chr3:49846592ENST00000424679+16161_2430548.0DomainSCAN box
HgeneZNF274chr19:58695365chr3:49846592ENST00000424679+16287_3600548.0DomainKRAB 2
HgeneZNF274chr19:58695365chr3:49846592ENST00000326804+29507_52911653.0Zinc fingerC2H2-type 1
HgeneZNF274chr19:58695365chr3:49846592ENST00000326804+29535_55711653.0Zinc fingerC2H2-type 2
HgeneZNF274chr19:58695365chr3:49846592ENST00000326804+29563_58511653.0Zinc fingerC2H2-type 3
HgeneZNF274chr19:58695365chr3:49846592ENST00000326804+29591_61311653.0Zinc fingerC2H2-type 4
HgeneZNF274chr19:58695365chr3:49846592ENST00000326804+29619_64111653.0Zinc fingerC2H2-type 5
HgeneZNF274chr19:58695365chr3:49846592ENST00000345813+28507_52911621.0Zinc fingerC2H2-type 1
HgeneZNF274chr19:58695365chr3:49846592ENST00000345813+28535_55711621.0Zinc fingerC2H2-type 2
HgeneZNF274chr19:58695365chr3:49846592ENST00000345813+28563_58511621.0Zinc fingerC2H2-type 3
HgeneZNF274chr19:58695365chr3:49846592ENST00000345813+28591_61311621.0Zinc fingerC2H2-type 4
HgeneZNF274chr19:58695365chr3:49846592ENST00000345813+28619_64111621.0Zinc fingerC2H2-type 5
HgeneZNF274chr19:58695365chr3:49846592ENST00000424679+16507_5290548.0Zinc fingerC2H2-type 1
HgeneZNF274chr19:58695365chr3:49846592ENST00000424679+16535_5570548.0Zinc fingerC2H2-type 2
HgeneZNF274chr19:58695365chr3:49846592ENST00000424679+16563_5850548.0Zinc fingerC2H2-type 3
HgeneZNF274chr19:58695365chr3:49846592ENST00000424679+16591_6130548.0Zinc fingerC2H2-type 4
HgeneZNF274chr19:58695365chr3:49846592ENST00000424679+16619_6410548.0Zinc fingerC2H2-type 5
TgeneUBA7chr19:58695365chr3:49846592ENST000003334861624442_4717211013.0Nucleotide bindingATP
TgeneUBA7chr19:58695365chr3:49846592ENST00000333486162423_5757211013.0RegionNote=2 approximate repeats
TgeneUBA7chr19:58695365chr3:49846592ENST00000333486162423_1597211013.0RepeatNote=1-1
TgeneUBA7chr19:58695365chr3:49846592ENST000003334861624423_5757211013.0RepeatNote=1-2


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Fusion Gene Sequence for ZNF274-UBA7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>101756_101756_1_ZNF274-UBA7_ZNF274_chr19_58695365_ENST00000326804_UBA7_chr3_49846592_ENST00000333486_length(transcript)=1469nt_BP=492nt
CGCCCCCACCGCCACCCAACCAAGCATCACCCATTCCAGCACTTCCGGCCTGACCCCTGTCCAGCGCCTTTCCTTTCTCCAGCTTCTGCT
CTGCCCCAAGAGTGGTCGCCTTCGTGGCAGGGCACGACTCTCTCCCAGCTCGGGTCGCCGCCCACATTAGTGTGGGGCCCTGCGGCCTAG
CGTCCCTCACCAGAGGCCTCCCCTTGCCTAGCTGGACCGCCGAGGGACATCGACGAGTATCCTCCTCCTGCTGTCCCCGGCTTCGCCTGC
CGCCCCTAACCGGCCAGTCAAGATGGCCGCCGCTGGGTGAGGCAAGCTGGCGCGCCGCGGGGGCGTCTGGGAGTTGTAGTTCGGGACGGC
GGGCTGACGCACTTCGCCGCCGGCCGACGGGCGCCATTGTGCGGCGCGCGCCGGGACTCTGCCCACTTCCACCAGAGACACATTGAGAAG
GAGGAAACTATGGCCTCCAGGCTTCCGACGGCCTGGTCCTGTGACACACACCTCCTCTACGTACTGGCAGCTGCCAACCTGTATGCCCAG
ATGCATGGGCTGCCTGGCTCACAGGACTGGACTGCACTCAGGGAGCTGCTGAAGCTGCTGCCACAGCCTGACCCCCAACAGATGGCCCCC
ATCTTTGCTAGTAATCTAGAGCTGGCTTCGGCTTCTGCTGAGTTTGGCCCTGAGCAGCAGAAGGAACTGAACAAAGCCCTGGAAGTCTGG
AGTGTGGGCCCTCCCCTGAAGCCTCTGATGTTTGAGAAGGATGATGACAGCAACTTCCATGTGGACTTTGTGGTAGCGGCAGCTAGCCTG
AGATGTCAGAACTACGGGATTCCACCGGTCAACCGTGCCCAGAGCAAGCGAATTGTGGGCCAGATTATCCCAGCCATTGCCACCACTACA
GCAGCTGTGGCAGGCCTGTTGGGCCTGGAGCTGTATAAGGTGGTGAGTGGGCCACGGCCTCGTAGTGCCTTTCGCCACAGCTACCTACAT
CTGGCTGAAAACTACCTCATCCGCTATATGCCTTTTGCCCCAGCCATCCAGACGTTCCATCACCTGAAGTGGACCTCTTGGGACCGTCTG
AAGGTACCAGCTGGGCAGCCTGAGAGGACCCTGGAGTCGCTGCTGGCTCATCTTCAGGAGCAGCACGGGTTGAGGGTGAGGATCCTGCTG
CACGGCTCAGCCCTGCTCTATGCGGCCGGATGGTCACCTGAAAAGCAGGCCCAGCACCTGCCCCTCAGGGTGACAGAACTGGTTCAGCAG
CTGACAGGCCAGGCACCTGCTCCTGGGCAGCGGGTGTTGGTGCTAGAGCTGAGCTGTGAGGGTGACGACGAGGACACTGCCTTCCCACCT
CTGCACTATGAGCTGTGACAAGGCAGCCACCCTGTCACCTAGCTCAATGGAGCCCCGGATCCCAAGCCCTGCATTGTAAGCCCACAGTAG

>101756_101756_1_ZNF274-UBA7_ZNF274_chr19_58695365_ENST00000326804_UBA7_chr3_49846592_ENST00000333486_length(amino acids)=343AA_BP=52
MGVVVRDGGLTHFAAGRRAPLCGARRDSAHFHQRHIEKEETMASRLPTAWSCDTHLLYVLAAANLYAQMHGLPGSQDWTALRELLKLLPQ
PDPQQMAPIFASNLELASASAEFGPEQQKELNKALEVWSVGPPLKPLMFEKDDDSNFHVDFVVAAASLRCQNYGIPPVNRAQSKRIVGQI
IPAIATTTAAVAGLLGLELYKVVSGPRPRSAFRHSYLHLAENYLIRYMPFAPAIQTFHHLKWTSWDRLKVPAGQPERTLESLLAHLQEQH

--------------------------------------------------------------
>101756_101756_2_ZNF274-UBA7_ZNF274_chr19_58695365_ENST00000345813_UBA7_chr3_49846592_ENST00000333486_length(transcript)=1469nt_BP=492nt
CGCCCCCACCGCCACCCAACCAAGCATCACCCATTCCAGCACTTCCGGCCTGACCCCTGTCCAGCGCCTTTCCTTTCTCCAGCTTCTGCT
CTGCCCCAAGAGTGGTCGCCTTCGTGGCAGGGCACGACTCTCTCCCAGCTCGGGTCGCCGCCCACATTAGTGTGGGGCCCTGCGGCCTAG
CGTCCCTCACCAGAGGCCTCCCCTTGCCTAGCTGGACCGCCGAGGGACATCGACGAGTATCCTCCTCCTGCTGTCCCCGGCTTCGCCTGC
CGCCCCTAACCGGCCAGTCAAGATGGCCGCCGCTGGGTGAGGCAAGCTGGCGCGCCGCGGGGGCGTCTGGGAGTTGTAGTTCGGGACGGC
GGGCTGACGCACTTCGCCGCCGGCCGACGGGCGCCATTGTGCGGCGCGCGCCGGGACTCTGCCCACTTCCACCAGAGACACATTGAGAAG
GAGGAAACTATGGCCTCCAGGCTTCCGACGGCCTGGTCCTGTGACACACACCTCCTCTACGTACTGGCAGCTGCCAACCTGTATGCCCAG
ATGCATGGGCTGCCTGGCTCACAGGACTGGACTGCACTCAGGGAGCTGCTGAAGCTGCTGCCACAGCCTGACCCCCAACAGATGGCCCCC
ATCTTTGCTAGTAATCTAGAGCTGGCTTCGGCTTCTGCTGAGTTTGGCCCTGAGCAGCAGAAGGAACTGAACAAAGCCCTGGAAGTCTGG
AGTGTGGGCCCTCCCCTGAAGCCTCTGATGTTTGAGAAGGATGATGACAGCAACTTCCATGTGGACTTTGTGGTAGCGGCAGCTAGCCTG
AGATGTCAGAACTACGGGATTCCACCGGTCAACCGTGCCCAGAGCAAGCGAATTGTGGGCCAGATTATCCCAGCCATTGCCACCACTACA
GCAGCTGTGGCAGGCCTGTTGGGCCTGGAGCTGTATAAGGTGGTGAGTGGGCCACGGCCTCGTAGTGCCTTTCGCCACAGCTACCTACAT
CTGGCTGAAAACTACCTCATCCGCTATATGCCTTTTGCCCCAGCCATCCAGACGTTCCATCACCTGAAGTGGACCTCTTGGGACCGTCTG
AAGGTACCAGCTGGGCAGCCTGAGAGGACCCTGGAGTCGCTGCTGGCTCATCTTCAGGAGCAGCACGGGTTGAGGGTGAGGATCCTGCTG
CACGGCTCAGCCCTGCTCTATGCGGCCGGATGGTCACCTGAAAAGCAGGCCCAGCACCTGCCCCTCAGGGTGACAGAACTGGTTCAGCAG
CTGACAGGCCAGGCACCTGCTCCTGGGCAGCGGGTGTTGGTGCTAGAGCTGAGCTGTGAGGGTGACGACGAGGACACTGCCTTCCCACCT
CTGCACTATGAGCTGTGACAAGGCAGCCACCCTGTCACCTAGCTCAATGGAGCCCCGGATCCCAAGCCCTGCATTGTAAGCCCACAGTAG

>101756_101756_2_ZNF274-UBA7_ZNF274_chr19_58695365_ENST00000345813_UBA7_chr3_49846592_ENST00000333486_length(amino acids)=343AA_BP=52
MGVVVRDGGLTHFAAGRRAPLCGARRDSAHFHQRHIEKEETMASRLPTAWSCDTHLLYVLAAANLYAQMHGLPGSQDWTALRELLKLLPQ
PDPQQMAPIFASNLELASASAEFGPEQQKELNKALEVWSVGPPLKPLMFEKDDDSNFHVDFVVAAASLRCQNYGIPPVNRAQSKRIVGQI
IPAIATTTAAVAGLLGLELYKVVSGPRPRSAFRHSYLHLAENYLIRYMPFAPAIQTFHHLKWTSWDRLKVPAGQPERTLESLLAHLQEQH

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Fusion Gene PPI Analysis for ZNF274-UBA7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF274-UBA7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF274-UBA7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource