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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ZNF276-VAC14 (FusionGDB2 ID:101763)

Fusion Gene Summary for ZNF276-VAC14

Fusion gene summary

Fusion gene information	Fusion gene name: ZNF276-VAC14
	Fusion gene ID: 101763
		Hgene	Tgene
	Gene symbol	ZNF276	VAC14
	Gene ID	92822	55697
	Gene name	zinc finger protein 276	VAC14 component of PIKFYVE complex
	Synonyms	CENP-Z\|CENPZ\|ZADT\|ZFP276\|ZNF477	ArPIKfyve\|TAX1BP2\|TRX
	Cytomap	16q24.3	16q22.1-q22.2
	Type of gene	protein-coding	protein-coding
	Description	zinc finger protein 276centromere protein Zzinc finger protein 276 homologzinc finger protein 477zinc finger, AD-type	protein VAC14 homologTax1 (human T-cell leukemia virus type I) binding proteinVac14, PIKFYVE complex component
	Modification date	20200320	20200327
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000289816, ENST00000443381, ENST00000446326, ENST00000568064,	ENST00000536184, ENST00000571759, ENST00000261776,
Fusion gene scores	* DoF score	4 X 4 X 3=48	12 X 10 X 9=1080
	# samples	4	14
	** MAII score	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(14/1080*10)=-2.94753258010586 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ZNF276 [Title/Abstract] AND VAC14 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ZNF276(89795726)-VAC14(70732714), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across ZNF276 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across VAC14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-XF-A9SK-01A	ZNF276	chr16	89795726	-	VAC14	chr16	70732714	-

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Fusion Gene ORF analysis for ZNF276-VAC14

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000289816	ENST00000536184	ZNF276	chr16	89795726	-	VAC14	chr16	70732714	-
5CDS-5UTR	ENST00000443381	ENST00000536184	ZNF276	chr16	89795726	-	VAC14	chr16	70732714	-
5CDS-5UTR	ENST00000446326	ENST00000536184	ZNF276	chr16	89795726	-	VAC14	chr16	70732714	-
5CDS-5UTR	ENST00000568064	ENST00000536184	ZNF276	chr16	89795726	-	VAC14	chr16	70732714	-
5CDS-intron	ENST00000289816	ENST00000571759	ZNF276	chr16	89795726	-	VAC14	chr16	70732714	-
5CDS-intron	ENST00000443381	ENST00000571759	ZNF276	chr16	89795726	-	VAC14	chr16	70732714	-
5CDS-intron	ENST00000446326	ENST00000571759	ZNF276	chr16	89795726	-	VAC14	chr16	70732714	-
5CDS-intron	ENST00000568064	ENST00000571759	ZNF276	chr16	89795726	-	VAC14	chr16	70732714	-
In-frame	ENST00000289816	ENST00000261776	ZNF276	chr16	89795726	-	VAC14	chr16	70732714	-
In-frame	ENST00000443381	ENST00000261776	ZNF276	chr16	89795726	-	VAC14	chr16	70732714	-
In-frame	ENST00000446326	ENST00000261776	ZNF276	chr16	89795726	-	VAC14	chr16	70732714	-
In-frame	ENST00000568064	ENST00000261776	ZNF276	chr16	89795726	-	VAC14	chr16	70732714	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000446326	ZNF276	chr16	89795726	-	ENST00000261776	VAC14	chr16	70732714	-	2292	1115	588	1802	404
ENST00000289816	ZNF276	chr16	89795726	-	ENST00000261776	VAC14	chr16	70732714	-	2433	1256	312	1943	543
ENST00000568064	ZNF276	chr16	89795726	-	ENST00000261776	VAC14	chr16	70732714	-	2360	1183	290	1870	526
ENST00000443381	ZNF276	chr16	89795726	-	ENST00000261776	VAC14	chr16	70732714	-	2443	1266	76	1953	625

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000446326	ENST00000261776	ZNF276	chr16	89795726	-	VAC14	chr16	70732714	-	0.18675932	0.8132407
ENST00000289816	ENST00000261776	ZNF276	chr16	89795726	-	VAC14	chr16	70732714	-	0.05357911	0.94642085
ENST00000568064	ENST00000261776	ZNF276	chr16	89795726	-	VAC14	chr16	70732714	-	0.13487446	0.8651255
ENST00000443381	ENST00000261776	ZNF276	chr16	89795726	-	VAC14	chr16	70732714	-	0.027082883	0.9729171

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Fusion Genomic Features for ZNF276-VAC14

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF276-VAC14

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:89795726/chr16:70732714)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ZNF276

chr16:89795726

chr16:70732714

ENST00000289816

77_163

314

540.0

Domain

ZAD

Hgene

ZNF276

chr16:89795726

chr16:70732714

ENST00000443381

77_163

389

615.0

Domain

ZAD

Tgene

VAC14

chr16:89795726

chr16:70732714

ENST00000261776

560_598

553

783.0

Repeat

Note=HEAT 6

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ZNF276

chr16:89795726

chr16:70732714

ENST00000289816

434_458

314

540.0

Zinc finger

C2H2-type 1

Hgene

ZNF276

chr16:89795726

chr16:70732714

ENST00000289816

465_490

314

540.0

Zinc finger

C2H2-type 2

Hgene

ZNF276

chr16:89795726

chr16:70732714

ENST00000289816

496_518

314

540.0

Zinc finger

C2H2-type 3

Hgene

ZNF276

chr16:89795726

chr16:70732714

ENST00000289816

524_546

314

540.0

Zinc finger

C2H2-type 4

Hgene

ZNF276

chr16:89795726

chr16:70732714

ENST00000289816

554_577

314

540.0

Zinc finger

C2H2-type 5

Hgene

ZNF276

chr16:89795726

chr16:70732714

ENST00000443381

434_458

389

615.0

Zinc finger

C2H2-type 1

Hgene

ZNF276

chr16:89795726

chr16:70732714

ENST00000443381

465_490

389

615.0

Zinc finger

C2H2-type 2

Hgene

ZNF276

chr16:89795726

chr16:70732714

ENST00000443381

496_518

389

615.0

Zinc finger

C2H2-type 3

Hgene

ZNF276

chr16:89795726

chr16:70732714

ENST00000443381

524_546

389

615.0

Zinc finger

C2H2-type 4

Hgene

ZNF276

chr16:89795726

chr16:70732714

ENST00000443381

554_577

389

615.0

Zinc finger

C2H2-type 5

Tgene

VAC14

chr16:89795726

chr16:70732714

ENST00000261776

171_208

553

783.0

Repeat

Note=HEAT 3

Tgene

VAC14

chr16:89795726

chr16:70732714

ENST00000261776

212_249

553

783.0

Repeat

Note=HEAT 4

Tgene

VAC14

chr16:89795726

chr16:70732714

ENST00000261776

438_475

553

783.0

Repeat

Note=HEAT 5

Tgene

VAC14

chr16:89795726

chr16:70732714

ENST00000261776

5_42

553

783.0

Repeat

Note=HEAT 1

Tgene

VAC14

chr16:89795726

chr16:70732714

ENST00000261776

89_126

553

783.0

Repeat

Note=HEAT 2

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Fusion Gene Sequence for ZNF276-VAC14

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>101763_101763_1_ZNF276-VAC14_ZNF276_chr16_89795726_ENST00000289816_VAC14_chr16_70732714_ENST00000261776_length(transcript)=2433nt_BP=1256nt
GCACTTCCGGCGACGGGCCCCCTCCGCGCGTACTGCGGGCCCCACGGGTGTTAGTGGCGGGGGCGGCAGAGTCCGGGTGGGTTGTCGCGA
CGGAGCCGGGCCTCTTCGCCGTCTTGAGACGGGGCTGGCGAGAAGGGCCCCTCACGGAGTTGCCATGGGCGTCTAACCGCGGCAGCCAGG
CCCCTCTCTACGTGAGACCCCGGCCCCCCTCCCCTTTCTGCAGCCCGCCCGCCACCTGCGCGCCGCGTGGCCTCCGCCGGCGCCTGCCCG
CCCCGCGCCTCCGTCTCCCACGGAGCAGGCCGGGCTCTCGCCATGGGTCACTGTCGCCTCTGCCACGGGAAGTTTTCCTCGAGAAGCCTG
CGCAGCATCTCCGAGAGGGCGCCTGGAGCGAGCATGGAGAGGCCATCCGCAGAGGAGCGCGTGCTCGTACGGGACTTCCAGCGCCTGCTT
GGTGTGGCTGTCCGCCAGGACCCCACCTTGTCTCCGTTTGTCTGCAAGAGCTGCCACGCCCAGTTCTACCAGTGCCACAGCCTTCTCAAG
TCCTTCCTGCAGAGGGTCAACGCCTCCCCGGCTGGTCGCCGGAAGCCTTGTGCAAAGGTCGGTGCCCAGCCCCCAACAGGGGCAGAGGAG
GGAGCGTGTCTGGTGGATCTGATCACATCCAGCCCCCAGTGCCTGCACGGCTTGGTGGGGTGGGTGCATGGACATGCGGCCAGCTGCGGG
GCCCTGCCCCACCTTCAGAGGACACTGTCCTCCGAGTACTGCGGCGTCATCCAGGTCGTGTGGGGCTGCGACCAGGGCCACGACTACACC
ATGGATACCAGCTCCAGCTGCAAGGCCTTCTTGCTGGACAGTGCGCTGGCAGTCAAGTGGCCATGGGACAAAGAGACGGCGCCACGGCTG
CCCCAGCACCGAGGGTGGAACCCTGGGGATGCCCCTCAGACCTCCCAGGGTAGAGGGACAGGGACCCCAGTTGGGGCTGAGACCAAGACC
CTGCCCAGCACGGATGTGGCCCAGCCTCCTTCGGACAGCGACGCGGTGGGGCCCAGGTCGGGCTTCCCACCTCAGCCAAGCCTGCCCCTT
TGCAGGGCCCCAGGGCAGTTGGGTGAGAAGCAGCTTCCATCTTCAACCTCGGATGATCGGGTAAAAGACGAGTTCAGTGACCTTTCTGAG
GGAGACGTCTTGAGTGAAGATGAAAATGACAAGAAGCAAAATGCCCAGTCTTCGGACGAGTCCTTTGAGCCTTACCCAGAAAGGAAGCAG
CTGTGCCTCCTGCTGAATGCGGAGAACATCTTCCACTCAATGGCAGACATCCTGCTGCGGGAGGAGGACCTCAAGTTCGCCTCGACCATG
GTCCACGCCCTCAACACCATCCTGCTGACCTCCACAGAGCTCTTCCAGCTAAGGAACCAGCTGAAGGACCTGAAGACCCTGGAGAGCCAG
AACCTGTTCTGCTGCCTGTACCGCTCCTGGTGCCACAACCCAGTCACCACGGTGTCCCTCTGCTTCCTCACCCAGAACTACCGGCACGCC
TATGACCTCATCCAGAAGTTTGGGGACCTGGAGGTCACCGTGGACTTCCTCGCAGAGGTGGACAAGCTGGTGCAGCTGATTGAGTGCCCC
ATCTTCACATATCTGCGCCTGCAGCTGCTGGACGTGAAGAACAACCCCTACCTGATCAAGGCCCTCTACGGCCTGCTCATGCTCCTGCCG
CAGAGCAGCGCCTTCCAGCTGCTCTCGCACCGGCTCCAGTGCGTGCCCAACCCTGAGCTGCTGCAGACCGAAGACAGTCTAAAGGCAGCC
CCCAAGTCCCAGAAAGCTGACTCCCCTAGCATCGACTACGCAGAGCTGCTGCAGCACTTTGAGAAGGTCCAGAACAAGCACCTGGAAGTG
CGGCACCAGCGGAGCGGGCGTGGGGACCACCTGGACCGGAGGGTTGTCCTCTGACAGGCCTGGCACGGAGGAGGGCCCACCGAGTGGTCC
CATGAAACACTAAGGGTCGTCACGCCCTCCCGAGGAGCTCAAGGACCTGCCTGTCAGGACCAGGGCTGGGCCTGCCAACCCAGGGCAGTG
TTGGGGCCGGAGGCTGCTGTGTCTGCCCAAGCTCCTCTCAGAGTCCAGTCCCCAGGCCTCCAGCGCTGTCAGCTGCACCCTGGCATTCTC
ACAGAGCTGGCTGCCCACCCAGTGGGGGGCTATAGCCTCAGAGACCACTCATCCTCTGGAATCAACCTCTTTCTAATACCCTCTTGGAAA
AAGAGCTTGCCCCTCCTCCAGCACACTAGAGCTCTGGCCTTGTGTGTATATGTATACATACGTGAACACATGCCTGTGTGTGTGTGTGTG
TGTGTGTACTTGTATGCACGTAGGCACCAGCACAAAGATCTGAATGATGCACCCCACCCCCACCCCAATAAAGAAATAACAGAAAACCCT

>101763_101763_1_ZNF276-VAC14_ZNF276_chr16_89795726_ENST00000289816_VAC14_chr16_70732714_ENST00000261776_length(amino acids)=543AA_BP=315
MGHCRLCHGKFSSRSLRSISERAPGASMERPSAEERVLVRDFQRLLGVAVRQDPTLSPFVCKSCHAQFYQCHSLLKSFLQRVNASPAGRR
KPCAKVGAQPPTGAEEGACLVDLITSSPQCLHGLVGWVHGHAASCGALPHLQRTLSSEYCGVIQVVWGCDQGHDYTMDTSSSCKAFLLDS
ALAVKWPWDKETAPRLPQHRGWNPGDAPQTSQGRGTGTPVGAETKTLPSTDVAQPPSDSDAVGPRSGFPPQPSLPLCRAPGQLGEKQLPS
STSDDRVKDEFSDLSEGDVLSEDENDKKQNAQSSDESFEPYPERKQLCLLLNAENIFHSMADILLREEDLKFASTMVHALNTILLTSTEL
FQLRNQLKDLKTLESQNLFCCLYRSWCHNPVTTVSLCFLTQNYRHAYDLIQKFGDLEVTVDFLAEVDKLVQLIECPIFTYLRLQLLDVKN
NPYLIKALYGLLMLLPQSSAFQLLSHRLQCVPNPELLQTEDSLKAAPKSQKADSPSIDYAELLQHFEKVQNKHLEVRHQRSGRGDHLDRR

--------------------------------------------------------------
>101763_101763_2_ZNF276-VAC14_ZNF276_chr16_89795726_ENST00000443381_VAC14_chr16_70732714_ENST00000261776_length(transcript)=2443nt_BP=1266nt
CTCGCTTCCAGCGCGCCGAGCGGAGCCTAACGCCGGGTCCTCTAGGAACCTCGGGCCGGGCAGCACCCGCGGGATTCTGCTGGCGTCCTC
CGCTGCCATGAAGCGGGACCGGCTGGGCCGCTTCCTGTCTCCTGGGTCGTCCCGACAGTGCGGGGCCTCGGACGGCGGCGGCGGCGTCAG
CCGGACTCGGGGCCGCCCTTCCCTTAGCGGTGGGCCGAGGGTGGACGGGGCGACGGCGCGGCGCGCCTGGGGCCCGGTGGGGTCCTGCGG
GGACGCGGGCGAGGACGGCGCGGACGAGGCAGGAGCAGGCCGGGCTCTCGCCATGGGTCACTGTCGCCTCTGCCACGGGAAGTTTTCCTC
GAGAAGCCTGCGCAGCATCTCCGAGAGGGCGCCTGGAGCGAGCATGGAGAGGCCATCCGCAGAGGAGCGCGTGCTCGTACGGGACTTCCA
GCGCCTGCTTGGTGTGGCTGTCCGCCAGGACCCCACCTTGTCTCCGTTTGTCTGCAAGAGCTGCCACGCCCAGTTCTACCAGTGCCACAG
CCTTCTCAAGTCCTTCCTGCAGAGGGTCAACGCCTCCCCGGCTGGTCGCCGGAAGCCTTGTGCAAAGGTCGGTGCCCAGCCCCCAACAGG
GGCAGAGGAGGGAGCGTGTCTGGTGGATCTGATCACATCCAGCCCCCAGTGCCTGCACGGCTTGGTGGGGTGGGTGCATGGACATGCGGC
CAGCTGCGGGGCCCTGCCCCACCTTCAGAGGACACTGTCCTCCGAGTACTGCGGCGTCATCCAGGTCGTGTGGGGCTGCGACCAGGGCCA
CGACTACACCATGGATACCAGCTCCAGCTGCAAGGCCTTCTTGCTGGACAGTGCGCTGGCAGTCAAGTGGCCATGGGACAAAGAGACGGC
GCCACGGCTGCCCCAGCACCGAGGGTGGAACCCTGGGGATGCCCCTCAGACCTCCCAGGGTAGAGGGACAGGGACCCCAGTTGGGGCTGA
GACCAAGACCCTGCCCAGCACGGATGTGGCCCAGCCTCCTTCGGACAGCGACGCGGTGGGGCCCAGGTCGGGCTTCCCACCTCAGCCAAG
CCTGCCCCTTTGCAGGGCCCCAGGGCAGTTGGGTGAGAAGCAGCTTCCATCTTCAACCTCGGATGATCGGGTAAAAGACGAGTTCAGTGA
CCTTTCTGAGGGAGACGTCTTGAGTGAAGATGAAAATGACAAGAAGCAAAATGCCCAGTCTTCGGACGAGTCCTTTGAGCCTTACCCAGA
AAGGAAGCAGCTGTGCCTCCTGCTGAATGCGGAGAACATCTTCCACTCAATGGCAGACATCCTGCTGCGGGAGGAGGACCTCAAGTTCGC
CTCGACCATGGTCCACGCCCTCAACACCATCCTGCTGACCTCCACAGAGCTCTTCCAGCTAAGGAACCAGCTGAAGGACCTGAAGACCCT
GGAGAGCCAGAACCTGTTCTGCTGCCTGTACCGCTCCTGGTGCCACAACCCAGTCACCACGGTGTCCCTCTGCTTCCTCACCCAGAACTA
CCGGCACGCCTATGACCTCATCCAGAAGTTTGGGGACCTGGAGGTCACCGTGGACTTCCTCGCAGAGGTGGACAAGCTGGTGCAGCTGAT
TGAGTGCCCCATCTTCACATATCTGCGCCTGCAGCTGCTGGACGTGAAGAACAACCCCTACCTGATCAAGGCCCTCTACGGCCTGCTCAT
GCTCCTGCCGCAGAGCAGCGCCTTCCAGCTGCTCTCGCACCGGCTCCAGTGCGTGCCCAACCCTGAGCTGCTGCAGACCGAAGACAGTCT
AAAGGCAGCCCCCAAGTCCCAGAAAGCTGACTCCCCTAGCATCGACTACGCAGAGCTGCTGCAGCACTTTGAGAAGGTCCAGAACAAGCA
CCTGGAAGTGCGGCACCAGCGGAGCGGGCGTGGGGACCACCTGGACCGGAGGGTTGTCCTCTGACAGGCCTGGCACGGAGGAGGGCCCAC
CGAGTGGTCCCATGAAACACTAAGGGTCGTCACGCCCTCCCGAGGAGCTCAAGGACCTGCCTGTCAGGACCAGGGCTGGGCCTGCCAACC
CAGGGCAGTGTTGGGGCCGGAGGCTGCTGTGTCTGCCCAAGCTCCTCTCAGAGTCCAGTCCCCAGGCCTCCAGCGCTGTCAGCTGCACCC
TGGCATTCTCACAGAGCTGGCTGCCCACCCAGTGGGGGGCTATAGCCTCAGAGACCACTCATCCTCTGGAATCAACCTCTTTCTAATACC
CTCTTGGAAAAAGAGCTTGCCCCTCCTCCAGCACACTAGAGCTCTGGCCTTGTGTGTATATGTATACATACGTGAACACATGCCTGTGTG
TGTGTGTGTGTGTGTGTACTTGTATGCACGTAGGCACCAGCACAAAGATCTGAATGATGCACCCCACCCCCACCCCAATAAAGAAATAAC

>101763_101763_2_ZNF276-VAC14_ZNF276_chr16_89795726_ENST00000443381_VAC14_chr16_70732714_ENST00000261776_length(amino acids)=625AA_BP=397
MLASSAAMKRDRLGRFLSPGSSRQCGASDGGGGVSRTRGRPSLSGGPRVDGATARRAWGPVGSCGDAGEDGADEAGAGRALAMGHCRLCH
GKFSSRSLRSISERAPGASMERPSAEERVLVRDFQRLLGVAVRQDPTLSPFVCKSCHAQFYQCHSLLKSFLQRVNASPAGRRKPCAKVGA
QPPTGAEEGACLVDLITSSPQCLHGLVGWVHGHAASCGALPHLQRTLSSEYCGVIQVVWGCDQGHDYTMDTSSSCKAFLLDSALAVKWPW
DKETAPRLPQHRGWNPGDAPQTSQGRGTGTPVGAETKTLPSTDVAQPPSDSDAVGPRSGFPPQPSLPLCRAPGQLGEKQLPSSTSDDRVK
DEFSDLSEGDVLSEDENDKKQNAQSSDESFEPYPERKQLCLLLNAENIFHSMADILLREEDLKFASTMVHALNTILLTSTELFQLRNQLK
DLKTLESQNLFCCLYRSWCHNPVTTVSLCFLTQNYRHAYDLIQKFGDLEVTVDFLAEVDKLVQLIECPIFTYLRLQLLDVKNNPYLIKAL

--------------------------------------------------------------
>101763_101763_3_ZNF276-VAC14_ZNF276_chr16_89795726_ENST00000446326_VAC14_chr16_70732714_ENST00000261776_length(transcript)=2292nt_BP=1115nt
AAATCTACCATCTCTGCCCAGAAAAATGCACGAACGCACGGACCTGCCCGTCACTCGGATTTTGGAAGGTGGCCTGGCGGACCCTCCTGC
TACATCTCCTCTACAGGTGGAGCCCAGGCTGTGATGCACCGGCTCAGCGAGCGGAGTGGAAAGCCAAGGTCCGCAGGATCTGAGCTGTCC
AAGGAGCAGGCCGGGCTCTCGCCATGGGTCACTGTCGCCTCTGCCACGGGAAGTTTTCCTCGAGAAGCCTGCGCAGCATCTCCGAGAGGG
CGCCTGGAGCGAGCATGGAGAGGCCATCCGCAGAGGAGCGCGTGCTCGTACGGGACTTCCAGCGCCTGCTTGGTGTGGCTGTCCGCCAGG
ACCCCACCTTGTCTCCGTTTGTCTGCAAGAGCTGCCACGCCCAGTTCTACCAGTGCCACAGCCTTCTCAAGTCCTTCCTGCAGAGGGTCA
ACGCCTCCCCGGCTGGTCGCCGGAAGCCTTGTGCAAAGGTCGGTGCCCAGCCCCCAACAGGGGCAGAGGAGGGAGCGTGTCTGGTGGATC
TGATCACATCCAGCCCCCAGTGCCTGCACGGCTTGGTGGGGTGGGTGCATGGACATGCGGCCAGCTGCGGGGCCCTGCCCCACCTTCAGA
GGACACTGTCCTCCGAGTACTGCGGCGTCATCCAGGTCGTGTGGGGCTGCGACCAGGGCCACGACTACACCATGGATACCAGCTCCAGCT
GCAAGGCCTTCTTGCTGGACAGTGCGCTGGCAGTCAAGTGGCCATGGGACAAAGAGACGGCGCCACGGCTGCCCCAGCACCGAGGGTGGA
ACCCTGGGGATGCCCCTCAGACCTCCCAGGGTAGAGGGACAGGGACCCCAGTTGGGGCTGAGACCAAGACCCTGCCCAGCACGGATGTGG
CCCAGCCTCCTTCGGACAGCGACGCGGTGGGGCCCAGGTCGGGCTTCCCACCTCAGCCAAGCCTGCCCCTTTGCAGGGCCCCAGGGCAGT
TGGGTGAGAAGCAGCTTCCATCTTCAACCTCGGATGATCGGAGACGTCTTGAGTGAAGATGAAAATGACAAGAAGCAAAATGCCCAGTCT
TCGGACGAGTCCTTTGAGCCTTACCCAGAAAGGAAGCAGCTGTGCCTCCTGCTGAATGCGGAGAACATCTTCCACTCAATGGCAGACATC
CTGCTGCGGGAGGAGGACCTCAAGTTCGCCTCGACCATGGTCCACGCCCTCAACACCATCCTGCTGACCTCCACAGAGCTCTTCCAGCTA
AGGAACCAGCTGAAGGACCTGAAGACCCTGGAGAGCCAGAACCTGTTCTGCTGCCTGTACCGCTCCTGGTGCCACAACCCAGTCACCACG
GTGTCCCTCTGCTTCCTCACCCAGAACTACCGGCACGCCTATGACCTCATCCAGAAGTTTGGGGACCTGGAGGTCACCGTGGACTTCCTC
GCAGAGGTGGACAAGCTGGTGCAGCTGATTGAGTGCCCCATCTTCACATATCTGCGCCTGCAGCTGCTGGACGTGAAGAACAACCCCTAC
CTGATCAAGGCCCTCTACGGCCTGCTCATGCTCCTGCCGCAGAGCAGCGCCTTCCAGCTGCTCTCGCACCGGCTCCAGTGCGTGCCCAAC
CCTGAGCTGCTGCAGACCGAAGACAGTCTAAAGGCAGCCCCCAAGTCCCAGAAAGCTGACTCCCCTAGCATCGACTACGCAGAGCTGCTG
CAGCACTTTGAGAAGGTCCAGAACAAGCACCTGGAAGTGCGGCACCAGCGGAGCGGGCGTGGGGACCACCTGGACCGGAGGGTTGTCCTC
TGACAGGCCTGGCACGGAGGAGGGCCCACCGAGTGGTCCCATGAAACACTAAGGGTCGTCACGCCCTCCCGAGGAGCTCAAGGACCTGCC
TGTCAGGACCAGGGCTGGGCCTGCCAACCCAGGGCAGTGTTGGGGCCGGAGGCTGCTGTGTCTGCCCAAGCTCCTCTCAGAGTCCAGTCC
CCAGGCCTCCAGCGCTGTCAGCTGCACCCTGGCATTCTCACAGAGCTGGCTGCCCACCCAGTGGGGGGCTATAGCCTCAGAGACCACTCA
TCCTCTGGAATCAACCTCTTTCTAATACCCTCTTGGAAAAAGAGCTTGCCCCTCCTCCAGCACACTAGAGCTCTGGCCTTGTGTGTATAT
GTATACATACGTGAACACATGCCTGTGTGTGTGTGTGTGTGTGTGTACTTGTATGCACGTAGGCACCAGCACAAAGATCTGAATGATGCA

>101763_101763_3_ZNF276-VAC14_ZNF276_chr16_89795726_ENST00000446326_VAC14_chr16_70732714_ENST00000261776_length(amino acids)=404AA_BP=176
MDMRPAAGPCPTFRGHCPPSTAASSRSCGAATRATTTPWIPAPAARPSCWTVRWQSSGHGTKRRRHGCPSTEGGTLGMPLRPPRVEGQGP
QLGLRPRPCPARMWPSLLRTATRWGPGRASHLSQACPFAGPQGSWVRSSFHLQPRMIGDVLSEDENDKKQNAQSSDESFEPYPERKQLCL
LLNAENIFHSMADILLREEDLKFASTMVHALNTILLTSTELFQLRNQLKDLKTLESQNLFCCLYRSWCHNPVTTVSLCFLTQNYRHAYDL
IQKFGDLEVTVDFLAEVDKLVQLIECPIFTYLRLQLLDVKNNPYLIKALYGLLMLLPQSSAFQLLSHRLQCVPNPELLQTEDSLKAAPKS

--------------------------------------------------------------
>101763_101763_4_ZNF276-VAC14_ZNF276_chr16_89795726_ENST00000568064_VAC14_chr16_70732714_ENST00000261776_length(transcript)=2360nt_BP=1183nt
TCCGCGCGTACTGCGGGCCCCACGGGTGTTAGTGGCGGGGGCGGCAGAGTCCGGGTGGGTTGTCGCGACGGAGCCGGGCCTCTTCGCCGT
CTTGAGACGGGGCTGGCGAGAAGGGCCCCTCACGGAGTTGCCATGGGCGTCTAACCGCGGCAGCCAGGCCCCTCTCTACGTGAGACCCCG
GCCCCCCTCCCCTTTCTGCAGCCCGCCCGCCACCTGCGCGCCGCGTGGCCTCCGCCGGCGCCTGCCCGCCCCGCGCCTCCGTCTCCCACG
GAGCAGGCCGGGCTCTCGCCATGGGTCACTGTCGCCTCTGCCACGGGAAGTTTTCCTCGAGAAGCCTGCGCAGCATCTCCGAGAGGGCGC
CTGGAGCGAGCATGGAGAGGCCATCCGCAGAGGAGCGCGTGCTCGTACGGGACTTCCAGCGCCTGCTTGGTGTGGCTGTCCGCCAGGACC
CCACCTTGTCTCCGTTTGTCTGCAAGAGCTGCCACGCCCAGTTCTACCAGTGCCACAGCCTTCTCAAGTCCTTCCTGCAGAGGGTCAACG
CCTCCCCGGCTGGTCGCCGGAAGCCTTGTGCAAAGGTCGGTGCCCAGCCCCCAACAGGGGCAGAGGAGGGAGCGTGTCTGGCCCCCAGTG
CCTGCACGGCTTGGTGGGGTGGGTGCATGGACATGCGGCCAGCTGCGGGGCCCTGCCCCACCTTCAGAGGACACTGTCCTCCGAGTACTG
CGGCGTCATCCAGGTCGTGTGGGGCTGCGACCAGGGCCACGACTACACCATGGATACCAGCTCCAGCTGCAAGGCCTTCTTGCTGGACAG
TGCGCTGGCAGTCAAGTGGCCATGGGACAAAGAGACGGCGCCACGGCTGCCCCAGCACCGAGGGTGGAACCCTGGGGATGCCCCTCAGAC
CTCCCAGGGTAGAGGGACAGGGACCCCAGTTGGGGCTGAGACCAAGACCCTGCCCAGCACGGATGTGGCCCAGCCTCCTTCGGACAGCGA
CGCGGTGGGGCCCAGGTCGGGCTTCCCACCTCAGCCAAGCCTGCCCCTTTGCAGGGCCCCAGGGCAGTTGGGTGAGAAGCAGCTTCCATC
TTCAACCTCGGATGATCGGAGACGTCTTGAGTGAAGATGAAAATGACAAGAAGCAAAATGCCCAGTCTTCGGACGAGTCCTTTGAGCCTT
ACCCAGAAAGGAAGCAGCTGTGCCTCCTGCTGAATGCGGAGAACATCTTCCACTCAATGGCAGACATCCTGCTGCGGGAGGAGGACCTCA
AGTTCGCCTCGACCATGGTCCACGCCCTCAACACCATCCTGCTGACCTCCACAGAGCTCTTCCAGCTAAGGAACCAGCTGAAGGACCTGA
AGACCCTGGAGAGCCAGAACCTGTTCTGCTGCCTGTACCGCTCCTGGTGCCACAACCCAGTCACCACGGTGTCCCTCTGCTTCCTCACCC
AGAACTACCGGCACGCCTATGACCTCATCCAGAAGTTTGGGGACCTGGAGGTCACCGTGGACTTCCTCGCAGAGGTGGACAAGCTGGTGC
AGCTGATTGAGTGCCCCATCTTCACATATCTGCGCCTGCAGCTGCTGGACGTGAAGAACAACCCCTACCTGATCAAGGCCCTCTACGGCC
TGCTCATGCTCCTGCCGCAGAGCAGCGCCTTCCAGCTGCTCTCGCACCGGCTCCAGTGCGTGCCCAACCCTGAGCTGCTGCAGACCGAAG
ACAGTCTAAAGGCAGCCCCCAAGTCCCAGAAAGCTGACTCCCCTAGCATCGACTACGCAGAGCTGCTGCAGCACTTTGAGAAGGTCCAGA
ACAAGCACCTGGAAGTGCGGCACCAGCGGAGCGGGCGTGGGGACCACCTGGACCGGAGGGTTGTCCTCTGACAGGCCTGGCACGGAGGAG
GGCCCACCGAGTGGTCCCATGAAACACTAAGGGTCGTCACGCCCTCCCGAGGAGCTCAAGGACCTGCCTGTCAGGACCAGGGCTGGGCCT
GCCAACCCAGGGCAGTGTTGGGGCCGGAGGCTGCTGTGTCTGCCCAAGCTCCTCTCAGAGTCCAGTCCCCAGGCCTCCAGCGCTGTCAGC
TGCACCCTGGCATTCTCACAGAGCTGGCTGCCCACCCAGTGGGGGGCTATAGCCTCAGAGACCACTCATCCTCTGGAATCAACCTCTTTC
TAATACCCTCTTGGAAAAAGAGCTTGCCCCTCCTCCAGCACACTAGAGCTCTGGCCTTGTGTGTATATGTATACATACGTGAACACATGC
CTGTGTGTGTGTGTGTGTGTGTGTACTTGTATGCACGTAGGCACCAGCACAAAGATCTGAATGATGCACCCCACCCCCACCCCAATAAAG

>101763_101763_4_ZNF276-VAC14_ZNF276_chr16_89795726_ENST00000568064_VAC14_chr16_70732714_ENST00000261776_length(amino acids)=526AA_BP=298
MGHCRLCHGKFSSRSLRSISERAPGASMERPSAEERVLVRDFQRLLGVAVRQDPTLSPFVCKSCHAQFYQCHSLLKSFLQRVNASPAGRR
KPCAKVGAQPPTGAEEGACLAPSACTAWWGGCMDMRPAAGPCPTFRGHCPPSTAASSRSCGAATRATTTPWIPAPAARPSCWTVRWQSSG
HGTKRRRHGCPSTEGGTLGMPLRPPRVEGQGPQLGLRPRPCPARMWPSLLRTATRWGPGRASHLSQACPFAGPQGSWVRSSFHLQPRMIG
DVLSEDENDKKQNAQSSDESFEPYPERKQLCLLLNAENIFHSMADILLREEDLKFASTMVHALNTILLTSTELFQLRNQLKDLKTLESQN
LFCCLYRSWCHNPVTTVSLCFLTQNYRHAYDLIQKFGDLEVTVDFLAEVDKLVQLIECPIFTYLRLQLLDVKNNPYLIKALYGLLMLLPQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZNF276-VAC14

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ZNF276-VAC14

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ZNF276-VAC14

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source