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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF277-CEACAM19 (FusionGDB2 ID:101765)

Fusion Gene Summary for ZNF277-CEACAM19

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF277-CEACAM19
Fusion gene ID: 101765
HgeneTgene
Gene symbol

ZNF277

CEACAM19

Gene ID

11179

56971

Gene namezinc finger protein 277CEA cell adhesion molecule 19
SynonymsNRIF4|ZNF277PCEACM19|CEAL1
Cytomap

7q31.1

19q13.31

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 277nuclear receptor-interacting factor 4zinc finger protein (C2H2 type) 277zinc finger protein 277 pseudogenecarcinoembryonic antigen-related cell adhesion molecule 19carcinoembryonic antigen related cell adhesion molecule 19carcinoembryonic antigen-like 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000361822, ENST00000421043, 
ENST00000450657, 		ENST00000480278, 
ENST00000358777, ENST00000403660, 
Fusion gene scores* DoF score8 X 4 X 7=2244 X 3 X 3=36
# samples 85
** MAII scorelog2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/36*10)=0.473931188332412
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZNF277 [Title/Abstract] AND CEACAM19 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF277(111846862)-CEACAM19(45175868), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ZNF277 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CEACAM19 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-B0-5081-01AZNF277chr7

111846862

-CEACAM19chr19

45175868

+
ChimerDB4KIRCTCGA-B0-5081-01AZNF277chr7

111846862

+CEACAM19chr19

45175868

+


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Fusion Gene ORF analysis for ZNF277-CEACAM19

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000361822ENST00000480278ZNF277chr7

111846862

+CEACAM19chr19

45175868

+
5CDS-3UTRENST00000421043ENST00000480278ZNF277chr7

111846862

+CEACAM19chr19

45175868

+
5CDS-3UTRENST00000450657ENST00000480278ZNF277chr7

111846862

+CEACAM19chr19

45175868

+
In-frameENST00000361822ENST00000358777ZNF277chr7

111846862

+CEACAM19chr19

45175868

+
In-frameENST00000361822ENST00000403660ZNF277chr7

111846862

+CEACAM19chr19

45175868

+
In-frameENST00000421043ENST00000358777ZNF277chr7

111846862

+CEACAM19chr19

45175868

+
In-frameENST00000421043ENST00000403660ZNF277chr7

111846862

+CEACAM19chr19

45175868

+
In-frameENST00000450657ENST00000358777ZNF277chr7

111846862

+CEACAM19chr19

45175868

+
In-frameENST00000450657ENST00000403660ZNF277chr7

111846862

+CEACAM19chr19

45175868

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000361822ZNF277chr7111846862+ENST00000358777CEACAM19chr1945175868+19342201291064311
ENST00000361822ZNF277chr7111846862+ENST00000403660CEACAM19chr1945175868+19372201291067312
ENST00000450657ZNF277chr7111846862+ENST00000358777CEACAM19chr1945175868+182110716951311
ENST00000450657ZNF277chr7111846862+ENST00000403660CEACAM19chr1945175868+182410716954312
ENST00000421043ZNF277chr7111846862+ENST00000358777CEACAM19chr1945175868+182511120955311
ENST00000421043ZNF277chr7111846862+ENST00000403660CEACAM19chr1945175868+182811120958312

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000361822ENST00000358777ZNF277chr7111846862+CEACAM19chr1945175868+0.0164147930.98358524
ENST00000361822ENST00000403660ZNF277chr7111846862+CEACAM19chr1945175868+0.016414630.98358536
ENST00000450657ENST00000358777ZNF277chr7111846862+CEACAM19chr1945175868+0.0153175270.98468244
ENST00000450657ENST00000403660ZNF277chr7111846862+CEACAM19chr1945175868+0.0159052650.9840948
ENST00000421043ENST00000358777ZNF277chr7111846862+CEACAM19chr1945175868+0.0162627850.9837373
ENST00000421043ENST00000403660ZNF277chr7111846862+CEACAM19chr1945175868+0.0164407790.9835592

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Fusion Genomic Features for ZNF277-CEACAM19


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ZNF277chr7111846862+CEACAM19chr1945175867+3.59E-070.99999964
ZNF277chr7111846862+CEACAM19chr1945175867+3.59E-070.99999964

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ZNF277-CEACAM19


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:111846862/chr19:45175868)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCEACAM19chr7:111846862chr19:45175868ENST0000035877708179_30018300.0Topological domainCytoplasmic
TgeneCEACAM19chr7:111846862chr19:45175868ENST000003587770833_15718300.0Topological domainExtracellular
TgeneCEACAM19chr7:111846862chr19:45175868ENST0000040366008179_30018301.0Topological domainCytoplasmic
TgeneCEACAM19chr7:111846862chr19:45175868ENST000004036600833_15718301.0Topological domainExtracellular
TgeneCEACAM19chr7:111846862chr19:45175868ENST0000035877708158_17818300.0TransmembraneHelical
TgeneCEACAM19chr7:111846862chr19:45175868ENST0000040366008158_17818301.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF277chr7:111846862chr19:45175868ENST00000361822+112224_24830451.0Zinc fingerC2H2-type 1
HgeneZNF277chr7:111846862chr19:45175868ENST00000361822+112355_38130451.0Zinc fingerC2H2-type 2


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Fusion Gene Sequence for ZNF277-CEACAM19


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>101765_101765_1_ZNF277-CEACAM19_ZNF277_chr7_111846862_ENST00000361822_CEACAM19_chr19_45175868_ENST00000358777_length(transcript)=1934nt_BP=220nt
GTCCAGAGCGCGGCGTAGGTGTGGAGAAAACATTACGTCGACGGGGAGTTCGCCTCCAGTAGCGTTTCTACTGGTGCCACCCCGCCTCCG
ACCCGCCCTGCGGCCCTCCCTTTTCTTTTCTGCCGGGTAATGGCTGCTTCCAAGACCCAGGGGGCTGTCGCCCGAATGCAGGAAGACCGT
GATGGGAGCTGCAGCACAGTCGGGGGTGTAGGTTATGGGGCCTCAATCCTGGTCCTCTGGATGCTCCAAGGCTCCCAGGCAGCTCTCTAC
ATCCAGAAGATTCCAGAGCAGCCTCAAAAGAACCAGGACCTTCTCCTGTCAGTCCAGGGTGTCCCAGACACCTTCCAGGACTTCAACTGG
TACCTGGGGGAGGAGACGTACGGAGGCACGAGGCTATTTACCTACATCCCTGGGATACAACGGCCTCAGAGGGATGGCAGTGCCATGGGA
CAGCGAGACATCGTGGGCTTCCCCAATGGTTCCATGCTGCTGCGCCGCGCCCAGCCTACAGACAGTGGCACCTACCAAGTAGCCATTACC
ATCAACTCTGAATGGACTATGAAGGCCAAGACTGAGGTCCAGGTAGCTGAAAAGAATAAGGAGCTGCCCAGTACACACCTGCCCACCAAC
GCTGGGATCCTGGCGGCCACCATCATTGGATCTCTTGCTGCCGGGGCCCTTCTCATCAGCTGCATTGCCTATCTCCTGGTGACAAGGAAC
TGGAGGGGCCAGAGCCACAGACTGCCTGCTCCGAGGGGCCAGGGATCTCTGTCCATCTTGTGCTCGGCTGTATCCCCAGTGCCTTCAGTG
ACGCCCAGCACATGGATGGCGACCACAGAGAAGCCAGAATTGGGCCCTGCTCATGATGCTGGTGACAACAACATCTATGAAGTGATGCCC
TCTCCAGTCCTCCTGGTGTCCCCCATCAGTGACACAAGGTCCATAAACCCAGCCCGGCCCCTGCCCACACCCCCACACCTGCAGGCGGAG
CCAGAGAACCACCAGTACCAGGACCTGCTAAACCCCGACCCTGCCCCCTACTGCCAGCTGGTGCCAACTTCCTGATGGGTCCTGGGCCAG
GCCAGCCAGGGAGAAGACAAGGCCCCAGCCCTCCTCTGGGAGCCTCACACCTGAGACCAGCAGGACAAGGCCATTGGGGGCTGTGGGGCC
GATGAGGTGGACTCAGCCAAAGACTCAGCAGCACATGGGGCAGGTGTCCTGGCAGGGGGACAGGAGACTGTAACAGGCCCAGGTCCTTGT
GCAGCCCGTGAATGCACGCCCGCCTTCGGTCTGTTCCTTCAAGCAAGCTGGCCTGGGCCATGTGCCTGTGAAAGGCAGGCTCTGGCCCCT
TTCCATGCCAAAGTCCCCCAAGATCTGGATATCTGGGGACAAGATGGTGGCCTCAGGCCTGCCTCCCAGGCAGTTGGCTGGGCTCCCAAC
TGTCTGTCCTCAATGCCCTACCCCAACTCCACTAGTGACCCTCAGAGTCTTCTCCCCTTAGGACAAGGCAGACACCCCACCATGCGGGCC
TCAGGTGGCAGAGAGGCCCAGCCTCACAGGCCTGTGGCCCCACACACCAGTCCCAGCAAGGTGACCACGGCTGCTGGACCCCTTCCCTGT
TCAGGCAGGCCCAGCCCCTCTCAGAACCTGCTGCCAGCTGCTGGTCTTGGCCCCCACCCTGAATCTTACTGAGTCCCTCTGGGCAGCAGC
TCCCTTCTCCACCCCACCCCAGCACCCGTCCCAAATGTGGCCTCAGCTTGTCCTCCCCTTCCCCAAACTATGCATTCATTCAGCAATAAA
TGAGCCTTTGCTGTATGCCAGACCCAGTTCTAGGCTCTTGCAGCCCTGGTAGAAAGCAAAACAAAAACTCCCGCTTTCCCAGAGGGTCAC

>101765_101765_1_ZNF277-CEACAM19_ZNF277_chr7_111846862_ENST00000361822_CEACAM19_chr19_45175868_ENST00000358777_length(amino acids)=311AA_BP=30
MAASKTQGAVARMQEDRDGSCSTVGGVGYGASILVLWMLQGSQAALYIQKIPEQPQKNQDLLLSVQGVPDTFQDFNWYLGEETYGGTRLF
TYIPGIQRPQRDGSAMGQRDIVGFPNGSMLLRRAQPTDSGTYQVAITINSEWTMKAKTEVQVAEKNKELPSTHLPTNAGILAATIIGSLA
AGALLISCIAYLLVTRNWRGQSHRLPAPRGQGSLSILCSAVSPVPSVTPSTWMATTEKPELGPAHDAGDNNIYEVMPSPVLLVSPISDTR

--------------------------------------------------------------
>101765_101765_2_ZNF277-CEACAM19_ZNF277_chr7_111846862_ENST00000361822_CEACAM19_chr19_45175868_ENST00000403660_length(transcript)=1937nt_BP=220nt
GTCCAGAGCGCGGCGTAGGTGTGGAGAAAACATTACGTCGACGGGGAGTTCGCCTCCAGTAGCGTTTCTACTGGTGCCACCCCGCCTCCG
ACCCGCCCTGCGGCCCTCCCTTTTCTTTTCTGCCGGGTAATGGCTGCTTCCAAGACCCAGGGGGCTGTCGCCCGAATGCAGGAAGACCGT
GATGGGAGCTGCAGCACAGTCGGGGGTGTAGGTTATGGGGCCTCAATCCTGGTCCTCTGGATGCTCCAAGGCTCCCAGGCAGCTCTCTAC
ATCCAGAAGATTCCAGAGCAGCCTCAAAAGAACCAGGACCTTCTCCTGTCAGTCCAGGGTGTCCCAGACACCTTCCAGGACTTCAACTGG
TACCTGGGGGAGGAGACGTACGGAGGCACGAGGCTATTTACCTACATCCCTGGGATACAACGGCCTCAGAGGGATGGCAGTGCCATGGGA
CAGCGAGACATCGTGGGCTTCCCCAATGGTTCCATGCTGCTGCGCCGCGCCCAGCCTACAGACAGTGGCACCTACCAAGTAGCCATTACC
ATCAACTCTGAATGGACTATGAAGGCCAAGACTGAGGTCCAGGTAGCTGAAAAGAATAAGGAGCTGCCCAGTACACACCTGCCCACCAAC
GCTGGGATCCTGGCGGCCACCATCATTGGATCTCTTGCTGCCGGGGCCCTTCTCATCAGCTGCATTGCCTATCTCCTGGTGACAAGGAAC
TGGAGGGGCCAGAGCCACAGACTGCCTGCTCCGAGGGGCCAGGGATCTCTGTCCATCTTGTGCTCGGCTGTATCCCCAGTGCCTTCAGTG
ACGCCCAGCACATGGATGGCGACCACAGAGAAGCCAGAATTGGGCCCTGCTCATGATGCTGGTGACAACAACATCTATGAAGTGATGCCC
TCTCCAGTCCTCCTGGTGTCCCCCATCAGTGACACAAGGTCCATAAACCCAGCCCGGCCCCTGCCCACACCCCCACACCTGCAGGCGGAG
CCAGAGAACCACCAGTACCAGCAGGACCTGCTAAACCCCGACCCTGCCCCCTACTGCCAGCTGGTGCCAACTTCCTGATGGGTCCTGGGC
CAGGCCAGCCAGGGAGAAGACAAGGCCCCAGCCCTCCTCTGGGAGCCTCACACCTGAGACCAGCAGGACAAGGCCATTGGGGGCTGTGGG
GCCGATGAGGTGGACTCAGCCAAAGACTCAGCAGCACATGGGGCAGGTGTCCTGGCAGGGGGACAGGAGACTGTAACAGGCCCAGGTCCT
TGTGCAGCCCGTGAATGCACGCCCGCCTTCGGTCTGTTCCTTCAAGCAAGCTGGCCTGGGCCATGTGCCTGTGAAAGGCAGGCTCTGGCC
CCTTTCCATGCCAAAGTCCCCCAAGATCTGGATATCTGGGGACAAGATGGTGGCCTCAGGCCTGCCTCCCAGGCAGTTGGCTGGGCTCCC
AACTGTCTGTCCTCAATGCCCTACCCCAACTCCACTAGTGACCCTCAGAGTCTTCTCCCCTTAGGACAAGGCAGACACCCCACCATGCGG
GCCTCAGGTGGCAGAGAGGCCCAGCCTCACAGGCCTGTGGCCCCACACACCAGTCCCAGCAAGGTGACCACGGCTGCTGGACCCCTTCCC
TGTTCAGGCAGGCCCAGCCCCTCTCAGAACCTGCTGCCAGCTGCTGGTCTTGGCCCCCACCCTGAATCTTACTGAGTCCCTCTGGGCAGC
AGCTCCCTTCTCCACCCCACCCCAGCACCCGTCCCAAATGTGGCCTCAGCTTGTCCTCCCCTTCCCCAAACTATGCATTCATTCAGCAAT
AAATGAGCCTTTGCTGTATGCCAGACCCAGTTCTAGGCTCTTGCAGCCCTGGTAGAAAGCAAAACAAAAACTCCCGCTTTCCCAGAGGGT

>101765_101765_2_ZNF277-CEACAM19_ZNF277_chr7_111846862_ENST00000361822_CEACAM19_chr19_45175868_ENST00000403660_length(amino acids)=312AA_BP=30
MAASKTQGAVARMQEDRDGSCSTVGGVGYGASILVLWMLQGSQAALYIQKIPEQPQKNQDLLLSVQGVPDTFQDFNWYLGEETYGGTRLF
TYIPGIQRPQRDGSAMGQRDIVGFPNGSMLLRRAQPTDSGTYQVAITINSEWTMKAKTEVQVAEKNKELPSTHLPTNAGILAATIIGSLA
AGALLISCIAYLLVTRNWRGQSHRLPAPRGQGSLSILCSAVSPVPSVTPSTWMATTEKPELGPAHDAGDNNIYEVMPSPVLLVSPISDTR

--------------------------------------------------------------
>101765_101765_3_ZNF277-CEACAM19_ZNF277_chr7_111846862_ENST00000421043_CEACAM19_chr19_45175868_ENST00000358777_length(transcript)=1825nt_BP=111nt
CTTTTCTTTTCTGCCGGGTAATGGCTGCTTCCAAGACCCAGGGGGCTGTCGCCCGAATGCAGGAAGACCGTGATGGGAGCTGCAGCACAG
TCGGGGGTGTAGGTTATGGGGCCTCAATCCTGGTCCTCTGGATGCTCCAAGGCTCCCAGGCAGCTCTCTACATCCAGAAGATTCCAGAGC
AGCCTCAAAAGAACCAGGACCTTCTCCTGTCAGTCCAGGGTGTCCCAGACACCTTCCAGGACTTCAACTGGTACCTGGGGGAGGAGACGT
ACGGAGGCACGAGGCTATTTACCTACATCCCTGGGATACAACGGCCTCAGAGGGATGGCAGTGCCATGGGACAGCGAGACATCGTGGGCT
TCCCCAATGGTTCCATGCTGCTGCGCCGCGCCCAGCCTACAGACAGTGGCACCTACCAAGTAGCCATTACCATCAACTCTGAATGGACTA
TGAAGGCCAAGACTGAGGTCCAGGTAGCTGAAAAGAATAAGGAGCTGCCCAGTACACACCTGCCCACCAACGCTGGGATCCTGGCGGCCA
CCATCATTGGATCTCTTGCTGCCGGGGCCCTTCTCATCAGCTGCATTGCCTATCTCCTGGTGACAAGGAACTGGAGGGGCCAGAGCCACA
GACTGCCTGCTCCGAGGGGCCAGGGATCTCTGTCCATCTTGTGCTCGGCTGTATCCCCAGTGCCTTCAGTGACGCCCAGCACATGGATGG
CGACCACAGAGAAGCCAGAATTGGGCCCTGCTCATGATGCTGGTGACAACAACATCTATGAAGTGATGCCCTCTCCAGTCCTCCTGGTGT
CCCCCATCAGTGACACAAGGTCCATAAACCCAGCCCGGCCCCTGCCCACACCCCCACACCTGCAGGCGGAGCCAGAGAACCACCAGTACC
AGGACCTGCTAAACCCCGACCCTGCCCCCTACTGCCAGCTGGTGCCAACTTCCTGATGGGTCCTGGGCCAGGCCAGCCAGGGAGAAGACA
AGGCCCCAGCCCTCCTCTGGGAGCCTCACACCTGAGACCAGCAGGACAAGGCCATTGGGGGCTGTGGGGCCGATGAGGTGGACTCAGCCA
AAGACTCAGCAGCACATGGGGCAGGTGTCCTGGCAGGGGGACAGGAGACTGTAACAGGCCCAGGTCCTTGTGCAGCCCGTGAATGCACGC
CCGCCTTCGGTCTGTTCCTTCAAGCAAGCTGGCCTGGGCCATGTGCCTGTGAAAGGCAGGCTCTGGCCCCTTTCCATGCCAAAGTCCCCC
AAGATCTGGATATCTGGGGACAAGATGGTGGCCTCAGGCCTGCCTCCCAGGCAGTTGGCTGGGCTCCCAACTGTCTGTCCTCAATGCCCT
ACCCCAACTCCACTAGTGACCCTCAGAGTCTTCTCCCCTTAGGACAAGGCAGACACCCCACCATGCGGGCCTCAGGTGGCAGAGAGGCCC
AGCCTCACAGGCCTGTGGCCCCACACACCAGTCCCAGCAAGGTGACCACGGCTGCTGGACCCCTTCCCTGTTCAGGCAGGCCCAGCCCCT
CTCAGAACCTGCTGCCAGCTGCTGGTCTTGGCCCCCACCCTGAATCTTACTGAGTCCCTCTGGGCAGCAGCTCCCTTCTCCACCCCACCC
CAGCACCCGTCCCAAATGTGGCCTCAGCTTGTCCTCCCCTTCCCCAAACTATGCATTCATTCAGCAATAAATGAGCCTTTGCTGTATGCC
AGACCCAGTTCTAGGCTCTTGCAGCCCTGGTAGAAAGCAAAACAAAAACTCCCGCTTTCCCAGAGGGTCACTTGGCAGGGGAAAGAATCA

>101765_101765_3_ZNF277-CEACAM19_ZNF277_chr7_111846862_ENST00000421043_CEACAM19_chr19_45175868_ENST00000358777_length(amino acids)=311AA_BP=30
MAASKTQGAVARMQEDRDGSCSTVGGVGYGASILVLWMLQGSQAALYIQKIPEQPQKNQDLLLSVQGVPDTFQDFNWYLGEETYGGTRLF
TYIPGIQRPQRDGSAMGQRDIVGFPNGSMLLRRAQPTDSGTYQVAITINSEWTMKAKTEVQVAEKNKELPSTHLPTNAGILAATIIGSLA
AGALLISCIAYLLVTRNWRGQSHRLPAPRGQGSLSILCSAVSPVPSVTPSTWMATTEKPELGPAHDAGDNNIYEVMPSPVLLVSPISDTR

--------------------------------------------------------------
>101765_101765_4_ZNF277-CEACAM19_ZNF277_chr7_111846862_ENST00000421043_CEACAM19_chr19_45175868_ENST00000403660_length(transcript)=1828nt_BP=111nt
CTTTTCTTTTCTGCCGGGTAATGGCTGCTTCCAAGACCCAGGGGGCTGTCGCCCGAATGCAGGAAGACCGTGATGGGAGCTGCAGCACAG
TCGGGGGTGTAGGTTATGGGGCCTCAATCCTGGTCCTCTGGATGCTCCAAGGCTCCCAGGCAGCTCTCTACATCCAGAAGATTCCAGAGC
AGCCTCAAAAGAACCAGGACCTTCTCCTGTCAGTCCAGGGTGTCCCAGACACCTTCCAGGACTTCAACTGGTACCTGGGGGAGGAGACGT
ACGGAGGCACGAGGCTATTTACCTACATCCCTGGGATACAACGGCCTCAGAGGGATGGCAGTGCCATGGGACAGCGAGACATCGTGGGCT
TCCCCAATGGTTCCATGCTGCTGCGCCGCGCCCAGCCTACAGACAGTGGCACCTACCAAGTAGCCATTACCATCAACTCTGAATGGACTA
TGAAGGCCAAGACTGAGGTCCAGGTAGCTGAAAAGAATAAGGAGCTGCCCAGTACACACCTGCCCACCAACGCTGGGATCCTGGCGGCCA
CCATCATTGGATCTCTTGCTGCCGGGGCCCTTCTCATCAGCTGCATTGCCTATCTCCTGGTGACAAGGAACTGGAGGGGCCAGAGCCACA
GACTGCCTGCTCCGAGGGGCCAGGGATCTCTGTCCATCTTGTGCTCGGCTGTATCCCCAGTGCCTTCAGTGACGCCCAGCACATGGATGG
CGACCACAGAGAAGCCAGAATTGGGCCCTGCTCATGATGCTGGTGACAACAACATCTATGAAGTGATGCCCTCTCCAGTCCTCCTGGTGT
CCCCCATCAGTGACACAAGGTCCATAAACCCAGCCCGGCCCCTGCCCACACCCCCACACCTGCAGGCGGAGCCAGAGAACCACCAGTACC
AGCAGGACCTGCTAAACCCCGACCCTGCCCCCTACTGCCAGCTGGTGCCAACTTCCTGATGGGTCCTGGGCCAGGCCAGCCAGGGAGAAG
ACAAGGCCCCAGCCCTCCTCTGGGAGCCTCACACCTGAGACCAGCAGGACAAGGCCATTGGGGGCTGTGGGGCCGATGAGGTGGACTCAG
CCAAAGACTCAGCAGCACATGGGGCAGGTGTCCTGGCAGGGGGACAGGAGACTGTAACAGGCCCAGGTCCTTGTGCAGCCCGTGAATGCA
CGCCCGCCTTCGGTCTGTTCCTTCAAGCAAGCTGGCCTGGGCCATGTGCCTGTGAAAGGCAGGCTCTGGCCCCTTTCCATGCCAAAGTCC
CCCAAGATCTGGATATCTGGGGACAAGATGGTGGCCTCAGGCCTGCCTCCCAGGCAGTTGGCTGGGCTCCCAACTGTCTGTCCTCAATGC
CCTACCCCAACTCCACTAGTGACCCTCAGAGTCTTCTCCCCTTAGGACAAGGCAGACACCCCACCATGCGGGCCTCAGGTGGCAGAGAGG
CCCAGCCTCACAGGCCTGTGGCCCCACACACCAGTCCCAGCAAGGTGACCACGGCTGCTGGACCCCTTCCCTGTTCAGGCAGGCCCAGCC
CCTCTCAGAACCTGCTGCCAGCTGCTGGTCTTGGCCCCCACCCTGAATCTTACTGAGTCCCTCTGGGCAGCAGCTCCCTTCTCCACCCCA
CCCCAGCACCCGTCCCAAATGTGGCCTCAGCTTGTCCTCCCCTTCCCCAAACTATGCATTCATTCAGCAATAAATGAGCCTTTGCTGTAT
GCCAGACCCAGTTCTAGGCTCTTGCAGCCCTGGTAGAAAGCAAAACAAAAACTCCCGCTTTCCCAGAGGGTCACTTGGCAGGGGAAAGAA

>101765_101765_4_ZNF277-CEACAM19_ZNF277_chr7_111846862_ENST00000421043_CEACAM19_chr19_45175868_ENST00000403660_length(amino acids)=312AA_BP=30
MAASKTQGAVARMQEDRDGSCSTVGGVGYGASILVLWMLQGSQAALYIQKIPEQPQKNQDLLLSVQGVPDTFQDFNWYLGEETYGGTRLF
TYIPGIQRPQRDGSAMGQRDIVGFPNGSMLLRRAQPTDSGTYQVAITINSEWTMKAKTEVQVAEKNKELPSTHLPTNAGILAATIIGSLA
AGALLISCIAYLLVTRNWRGQSHRLPAPRGQGSLSILCSAVSPVPSVTPSTWMATTEKPELGPAHDAGDNNIYEVMPSPVLLVSPISDTR

--------------------------------------------------------------
>101765_101765_5_ZNF277-CEACAM19_ZNF277_chr7_111846862_ENST00000450657_CEACAM19_chr19_45175868_ENST00000358777_length(transcript)=1821nt_BP=107nt
TCTTTTCTGCCGGGTAATGGCTGCTTCCAAGACCCAGGGGGCTGTCGCCCGAATGCAGGAAGACCGTGATGGGAGCTGCAGCACAGTCGG
GGGTGTAGGTTATGGGGCCTCAATCCTGGTCCTCTGGATGCTCCAAGGCTCCCAGGCAGCTCTCTACATCCAGAAGATTCCAGAGCAGCC
TCAAAAGAACCAGGACCTTCTCCTGTCAGTCCAGGGTGTCCCAGACACCTTCCAGGACTTCAACTGGTACCTGGGGGAGGAGACGTACGG
AGGCACGAGGCTATTTACCTACATCCCTGGGATACAACGGCCTCAGAGGGATGGCAGTGCCATGGGACAGCGAGACATCGTGGGCTTCCC
CAATGGTTCCATGCTGCTGCGCCGCGCCCAGCCTACAGACAGTGGCACCTACCAAGTAGCCATTACCATCAACTCTGAATGGACTATGAA
GGCCAAGACTGAGGTCCAGGTAGCTGAAAAGAATAAGGAGCTGCCCAGTACACACCTGCCCACCAACGCTGGGATCCTGGCGGCCACCAT
CATTGGATCTCTTGCTGCCGGGGCCCTTCTCATCAGCTGCATTGCCTATCTCCTGGTGACAAGGAACTGGAGGGGCCAGAGCCACAGACT
GCCTGCTCCGAGGGGCCAGGGATCTCTGTCCATCTTGTGCTCGGCTGTATCCCCAGTGCCTTCAGTGACGCCCAGCACATGGATGGCGAC
CACAGAGAAGCCAGAATTGGGCCCTGCTCATGATGCTGGTGACAACAACATCTATGAAGTGATGCCCTCTCCAGTCCTCCTGGTGTCCCC
CATCAGTGACACAAGGTCCATAAACCCAGCCCGGCCCCTGCCCACACCCCCACACCTGCAGGCGGAGCCAGAGAACCACCAGTACCAGGA
CCTGCTAAACCCCGACCCTGCCCCCTACTGCCAGCTGGTGCCAACTTCCTGATGGGTCCTGGGCCAGGCCAGCCAGGGAGAAGACAAGGC
CCCAGCCCTCCTCTGGGAGCCTCACACCTGAGACCAGCAGGACAAGGCCATTGGGGGCTGTGGGGCCGATGAGGTGGACTCAGCCAAAGA
CTCAGCAGCACATGGGGCAGGTGTCCTGGCAGGGGGACAGGAGACTGTAACAGGCCCAGGTCCTTGTGCAGCCCGTGAATGCACGCCCGC
CTTCGGTCTGTTCCTTCAAGCAAGCTGGCCTGGGCCATGTGCCTGTGAAAGGCAGGCTCTGGCCCCTTTCCATGCCAAAGTCCCCCAAGA
TCTGGATATCTGGGGACAAGATGGTGGCCTCAGGCCTGCCTCCCAGGCAGTTGGCTGGGCTCCCAACTGTCTGTCCTCAATGCCCTACCC
CAACTCCACTAGTGACCCTCAGAGTCTTCTCCCCTTAGGACAAGGCAGACACCCCACCATGCGGGCCTCAGGTGGCAGAGAGGCCCAGCC
TCACAGGCCTGTGGCCCCACACACCAGTCCCAGCAAGGTGACCACGGCTGCTGGACCCCTTCCCTGTTCAGGCAGGCCCAGCCCCTCTCA
GAACCTGCTGCCAGCTGCTGGTCTTGGCCCCCACCCTGAATCTTACTGAGTCCCTCTGGGCAGCAGCTCCCTTCTCCACCCCACCCCAGC
ACCCGTCCCAAATGTGGCCTCAGCTTGTCCTCCCCTTCCCCAAACTATGCATTCATTCAGCAATAAATGAGCCTTTGCTGTATGCCAGAC
CCAGTTCTAGGCTCTTGCAGCCCTGGTAGAAAGCAAAACAAAAACTCCCGCTTTCCCAGAGGGTCACTTGGCAGGGGAAAGAATCAGGAA

>101765_101765_5_ZNF277-CEACAM19_ZNF277_chr7_111846862_ENST00000450657_CEACAM19_chr19_45175868_ENST00000358777_length(amino acids)=311AA_BP=30
MAASKTQGAVARMQEDRDGSCSTVGGVGYGASILVLWMLQGSQAALYIQKIPEQPQKNQDLLLSVQGVPDTFQDFNWYLGEETYGGTRLF
TYIPGIQRPQRDGSAMGQRDIVGFPNGSMLLRRAQPTDSGTYQVAITINSEWTMKAKTEVQVAEKNKELPSTHLPTNAGILAATIIGSLA
AGALLISCIAYLLVTRNWRGQSHRLPAPRGQGSLSILCSAVSPVPSVTPSTWMATTEKPELGPAHDAGDNNIYEVMPSPVLLVSPISDTR

--------------------------------------------------------------
>101765_101765_6_ZNF277-CEACAM19_ZNF277_chr7_111846862_ENST00000450657_CEACAM19_chr19_45175868_ENST00000403660_length(transcript)=1824nt_BP=107nt
TCTTTTCTGCCGGGTAATGGCTGCTTCCAAGACCCAGGGGGCTGTCGCCCGAATGCAGGAAGACCGTGATGGGAGCTGCAGCACAGTCGG
GGGTGTAGGTTATGGGGCCTCAATCCTGGTCCTCTGGATGCTCCAAGGCTCCCAGGCAGCTCTCTACATCCAGAAGATTCCAGAGCAGCC
TCAAAAGAACCAGGACCTTCTCCTGTCAGTCCAGGGTGTCCCAGACACCTTCCAGGACTTCAACTGGTACCTGGGGGAGGAGACGTACGG
AGGCACGAGGCTATTTACCTACATCCCTGGGATACAACGGCCTCAGAGGGATGGCAGTGCCATGGGACAGCGAGACATCGTGGGCTTCCC
CAATGGTTCCATGCTGCTGCGCCGCGCCCAGCCTACAGACAGTGGCACCTACCAAGTAGCCATTACCATCAACTCTGAATGGACTATGAA
GGCCAAGACTGAGGTCCAGGTAGCTGAAAAGAATAAGGAGCTGCCCAGTACACACCTGCCCACCAACGCTGGGATCCTGGCGGCCACCAT
CATTGGATCTCTTGCTGCCGGGGCCCTTCTCATCAGCTGCATTGCCTATCTCCTGGTGACAAGGAACTGGAGGGGCCAGAGCCACAGACT
GCCTGCTCCGAGGGGCCAGGGATCTCTGTCCATCTTGTGCTCGGCTGTATCCCCAGTGCCTTCAGTGACGCCCAGCACATGGATGGCGAC
CACAGAGAAGCCAGAATTGGGCCCTGCTCATGATGCTGGTGACAACAACATCTATGAAGTGATGCCCTCTCCAGTCCTCCTGGTGTCCCC
CATCAGTGACACAAGGTCCATAAACCCAGCCCGGCCCCTGCCCACACCCCCACACCTGCAGGCGGAGCCAGAGAACCACCAGTACCAGCA
GGACCTGCTAAACCCCGACCCTGCCCCCTACTGCCAGCTGGTGCCAACTTCCTGATGGGTCCTGGGCCAGGCCAGCCAGGGAGAAGACAA
GGCCCCAGCCCTCCTCTGGGAGCCTCACACCTGAGACCAGCAGGACAAGGCCATTGGGGGCTGTGGGGCCGATGAGGTGGACTCAGCCAA
AGACTCAGCAGCACATGGGGCAGGTGTCCTGGCAGGGGGACAGGAGACTGTAACAGGCCCAGGTCCTTGTGCAGCCCGTGAATGCACGCC
CGCCTTCGGTCTGTTCCTTCAAGCAAGCTGGCCTGGGCCATGTGCCTGTGAAAGGCAGGCTCTGGCCCCTTTCCATGCCAAAGTCCCCCA
AGATCTGGATATCTGGGGACAAGATGGTGGCCTCAGGCCTGCCTCCCAGGCAGTTGGCTGGGCTCCCAACTGTCTGTCCTCAATGCCCTA
CCCCAACTCCACTAGTGACCCTCAGAGTCTTCTCCCCTTAGGACAAGGCAGACACCCCACCATGCGGGCCTCAGGTGGCAGAGAGGCCCA
GCCTCACAGGCCTGTGGCCCCACACACCAGTCCCAGCAAGGTGACCACGGCTGCTGGACCCCTTCCCTGTTCAGGCAGGCCCAGCCCCTC
TCAGAACCTGCTGCCAGCTGCTGGTCTTGGCCCCCACCCTGAATCTTACTGAGTCCCTCTGGGCAGCAGCTCCCTTCTCCACCCCACCCC
AGCACCCGTCCCAAATGTGGCCTCAGCTTGTCCTCCCCTTCCCCAAACTATGCATTCATTCAGCAATAAATGAGCCTTTGCTGTATGCCA
GACCCAGTTCTAGGCTCTTGCAGCCCTGGTAGAAAGCAAAACAAAAACTCCCGCTTTCCCAGAGGGTCACTTGGCAGGGGAAAGAATCAG

>101765_101765_6_ZNF277-CEACAM19_ZNF277_chr7_111846862_ENST00000450657_CEACAM19_chr19_45175868_ENST00000403660_length(amino acids)=312AA_BP=30
MAASKTQGAVARMQEDRDGSCSTVGGVGYGASILVLWMLQGSQAALYIQKIPEQPQKNQDLLLSVQGVPDTFQDFNWYLGEETYGGTRLF
TYIPGIQRPQRDGSAMGQRDIVGFPNGSMLLRRAQPTDSGTYQVAITINSEWTMKAKTEVQVAEKNKELPSTHLPTNAGILAATIIGSLA
AGALLISCIAYLLVTRNWRGQSHRLPAPRGQGSLSILCSAVSPVPSVTPSTWMATTEKPELGPAHDAGDNNIYEVMPSPVLLVSPISDTR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZNF277-CEACAM19


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF277-CEACAM19


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF277-CEACAM19


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource