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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF28-PPP1R37 (FusionGDB2 ID:101806)

Fusion Gene Summary for ZNF28-PPP1R37

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF28-PPP1R37
Fusion gene ID: 101806
HgeneTgene
Gene symbol

ZNF28

PPP1R37

Gene ID

7576

284352

Gene namezinc finger protein 28protein phosphatase 1 regulatory subunit 37
SynonymsKOX24LRRC68
Cytomap

19q13.41

19q13.32

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 28zinc finger protein KOX24protein phosphatase 1 regulatory subunit 37leucine rich repeat containing 68leucine-rich repeat-containing protein 68
Modification date2020032020200313
UniProtAcc.

O75864

Ensembl transtripts involved in fusion geneENST00000457749, ENST00000594602, 
ENST00000414252, ENST00000464469, 
ENST00000339844, ENST00000360272, 
ENST00000438150, 		ENST00000496125, 
ENST00000221462, ENST00000421905, 
Fusion gene scores* DoF score3 X 3 X 2=186 X 4 X 4=96
# samples 37
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(7/96*10)=-0.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF28 [Title/Abstract] AND PPP1R37 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF28(53321197)-PPP1R37(45641772), # samples:1
Anticipated loss of major functional domain due to fusion event.ZNF28-PPP1R37 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePPP1R37

GO:0010923

negative regulation of phosphatase activity

19389623


check buttonFusion gene breakpoints across ZNF28 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PPP1R37 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-DU-7010ZNF28chr19

53321197

-PPP1R37chr19

45641772

+


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Fusion Gene ORF analysis for ZNF28-PPP1R37

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000457749ENST00000496125ZNF28chr19

53321197

-PPP1R37chr19

45641772

+
5CDS-intronENST00000594602ENST00000496125ZNF28chr19

53321197

-PPP1R37chr19

45641772

+
5UTR-3CDSENST00000414252ENST00000221462ZNF28chr19

53321197

-PPP1R37chr19

45641772

+
5UTR-3CDSENST00000414252ENST00000421905ZNF28chr19

53321197

-PPP1R37chr19

45641772

+
5UTR-3CDSENST00000464469ENST00000221462ZNF28chr19

53321197

-PPP1R37chr19

45641772

+
5UTR-3CDSENST00000464469ENST00000421905ZNF28chr19

53321197

-PPP1R37chr19

45641772

+
5UTR-intronENST00000414252ENST00000496125ZNF28chr19

53321197

-PPP1R37chr19

45641772

+
5UTR-intronENST00000464469ENST00000496125ZNF28chr19

53321197

-PPP1R37chr19

45641772

+
Frame-shiftENST00000594602ENST00000221462ZNF28chr19

53321197

-PPP1R37chr19

45641772

+
Frame-shiftENST00000594602ENST00000421905ZNF28chr19

53321197

-PPP1R37chr19

45641772

+
In-frameENST00000457749ENST00000221462ZNF28chr19

53321197

-PPP1R37chr19

45641772

+
In-frameENST00000457749ENST00000421905ZNF28chr19

53321197

-PPP1R37chr19

45641772

+
intron-3CDSENST00000339844ENST00000221462ZNF28chr19

53321197

-PPP1R37chr19

45641772

+
intron-3CDSENST00000339844ENST00000421905ZNF28chr19

53321197

-PPP1R37chr19

45641772

+
intron-3CDSENST00000360272ENST00000221462ZNF28chr19

53321197

-PPP1R37chr19

45641772

+
intron-3CDSENST00000360272ENST00000421905ZNF28chr19

53321197

-PPP1R37chr19

45641772

+
intron-3CDSENST00000438150ENST00000221462ZNF28chr19

53321197

-PPP1R37chr19

45641772

+
intron-3CDSENST00000438150ENST00000421905ZNF28chr19

53321197

-PPP1R37chr19

45641772

+
intron-intronENST00000339844ENST00000496125ZNF28chr19

53321197

-PPP1R37chr19

45641772

+
intron-intronENST00000360272ENST00000496125ZNF28chr19

53321197

-PPP1R37chr19

45641772

+
intron-intronENST00000438150ENST00000496125ZNF28chr19

53321197

-PPP1R37chr19

45641772

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000457749ZNF28chr1953321197-ENST00000421905PPP1R37chr1945641772+19971351911996602
ENST00000457749ZNF28chr1953321197-ENST00000221462PPP1R37chr1945641772+27321351912008605

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000457749ENST00000421905ZNF28chr1953321197-PPP1R37chr1945641772+0.0376670320.9623329
ENST00000457749ENST00000221462ZNF28chr1953321197-PPP1R37chr1945641772+0.0368820020.9631181

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Fusion Genomic Features for ZNF28-PPP1R37


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ZNF28chr1953321196-PPP1R37chr1945641771+2.20E-101
ZNF28chr1953321196-PPP1R37chr1945641771+2.20E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ZNF28-PPP1R37


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:53321197/chr19:45641772)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.PPP1R37

O75864

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000269|PubMed:19389623}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePPP1R37chr19:53321197chr19:45641772ENST00000221462013514_52267741.6666666666666Compositional biasNote=Poly-Glu
TgenePPP1R37chr19:53321197chr19:45641772ENST00000221462013527_65367741.6666666666666Compositional biasNote=Pro-rich
TgenePPP1R37chr19:53321197chr19:45641772ENST00000221462013220_24067741.6666666666666RepeatNote=LRR 1
TgenePPP1R37chr19:53321197chr19:45641772ENST00000221462013248_26967741.6666666666666RepeatNote=LRR 2
TgenePPP1R37chr19:53321197chr19:45641772ENST00000221462013277_29767741.6666666666666RepeatNote=LRR 3
TgenePPP1R37chr19:53321197chr19:45641772ENST00000221462013306_32667741.6666666666666RepeatNote=LRR 4
TgenePPP1R37chr19:53321197chr19:45641772ENST00000221462013334_35467741.6666666666666RepeatNote=LRR 5

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF28chr19:53321197chr19:45641772ENST00000360272-138_810666.0DomainKRAB
HgeneZNF28chr19:53321197chr19:45641772ENST00000414252-238_810666.0DomainKRAB
HgeneZNF28chr19:53321197chr19:45641772ENST00000438150-128_810666.0DomainKRAB
HgeneZNF28chr19:53321197chr19:45641772ENST00000457749-248_815719.0DomainKRAB
HgeneZNF28chr19:53321197chr19:45641772ENST00000360272-13215_2370666.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF28chr19:53321197chr19:45641772ENST00000360272-13243_2650666.0Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF28chr19:53321197chr19:45641772ENST00000360272-13271_2930666.0Zinc fingerC2H2-type 3
HgeneZNF28chr19:53321197chr19:45641772ENST00000360272-13299_3210666.0Zinc fingerC2H2-type 4%3B degenerate
HgeneZNF28chr19:53321197chr19:45641772ENST00000360272-13327_3490666.0Zinc fingerC2H2-type 5
HgeneZNF28chr19:53321197chr19:45641772ENST00000360272-13355_3770666.0Zinc fingerC2H2-type 6
HgeneZNF28chr19:53321197chr19:45641772ENST00000360272-13383_4050666.0Zinc fingerC2H2-type 7
HgeneZNF28chr19:53321197chr19:45641772ENST00000360272-13411_4330666.0Zinc fingerC2H2-type 8
HgeneZNF28chr19:53321197chr19:45641772ENST00000360272-13439_4610666.0Zinc fingerC2H2-type 9
HgeneZNF28chr19:53321197chr19:45641772ENST00000360272-13467_4890666.0Zinc fingerC2H2-type 10
HgeneZNF28chr19:53321197chr19:45641772ENST00000360272-13495_5170666.0Zinc fingerC2H2-type 11
HgeneZNF28chr19:53321197chr19:45641772ENST00000360272-13523_5450666.0Zinc fingerC2H2-type 12
HgeneZNF28chr19:53321197chr19:45641772ENST00000360272-13551_5730666.0Zinc fingerC2H2-type 13
HgeneZNF28chr19:53321197chr19:45641772ENST00000360272-13579_6010666.0Zinc fingerC2H2-type 14
HgeneZNF28chr19:53321197chr19:45641772ENST00000360272-13607_6290666.0Zinc fingerC2H2-type 15
HgeneZNF28chr19:53321197chr19:45641772ENST00000360272-13635_6570666.0Zinc fingerC2H2-type 16
HgeneZNF28chr19:53321197chr19:45641772ENST00000360272-13663_6850666.0Zinc fingerC2H2-type 17
HgeneZNF28chr19:53321197chr19:45641772ENST00000360272-13691_7130666.0Zinc fingerC2H2-type 18
HgeneZNF28chr19:53321197chr19:45641772ENST00000414252-23215_2370666.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF28chr19:53321197chr19:45641772ENST00000414252-23243_2650666.0Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF28chr19:53321197chr19:45641772ENST00000414252-23271_2930666.0Zinc fingerC2H2-type 3
HgeneZNF28chr19:53321197chr19:45641772ENST00000414252-23299_3210666.0Zinc fingerC2H2-type 4%3B degenerate
HgeneZNF28chr19:53321197chr19:45641772ENST00000414252-23327_3490666.0Zinc fingerC2H2-type 5
HgeneZNF28chr19:53321197chr19:45641772ENST00000414252-23355_3770666.0Zinc fingerC2H2-type 6
HgeneZNF28chr19:53321197chr19:45641772ENST00000414252-23383_4050666.0Zinc fingerC2H2-type 7
HgeneZNF28chr19:53321197chr19:45641772ENST00000414252-23411_4330666.0Zinc fingerC2H2-type 8
HgeneZNF28chr19:53321197chr19:45641772ENST00000414252-23439_4610666.0Zinc fingerC2H2-type 9
HgeneZNF28chr19:53321197chr19:45641772ENST00000414252-23467_4890666.0Zinc fingerC2H2-type 10
HgeneZNF28chr19:53321197chr19:45641772ENST00000414252-23495_5170666.0Zinc fingerC2H2-type 11
HgeneZNF28chr19:53321197chr19:45641772ENST00000414252-23523_5450666.0Zinc fingerC2H2-type 12
HgeneZNF28chr19:53321197chr19:45641772ENST00000414252-23551_5730666.0Zinc fingerC2H2-type 13
HgeneZNF28chr19:53321197chr19:45641772ENST00000414252-23579_6010666.0Zinc fingerC2H2-type 14
HgeneZNF28chr19:53321197chr19:45641772ENST00000414252-23607_6290666.0Zinc fingerC2H2-type 15
HgeneZNF28chr19:53321197chr19:45641772ENST00000414252-23635_6570666.0Zinc fingerC2H2-type 16
HgeneZNF28chr19:53321197chr19:45641772ENST00000414252-23663_6850666.0Zinc fingerC2H2-type 17
HgeneZNF28chr19:53321197chr19:45641772ENST00000414252-23691_7130666.0Zinc fingerC2H2-type 18
HgeneZNF28chr19:53321197chr19:45641772ENST00000438150-12215_2370666.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF28chr19:53321197chr19:45641772ENST00000438150-12243_2650666.0Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF28chr19:53321197chr19:45641772ENST00000438150-12271_2930666.0Zinc fingerC2H2-type 3
HgeneZNF28chr19:53321197chr19:45641772ENST00000438150-12299_3210666.0Zinc fingerC2H2-type 4%3B degenerate
HgeneZNF28chr19:53321197chr19:45641772ENST00000438150-12327_3490666.0Zinc fingerC2H2-type 5
HgeneZNF28chr19:53321197chr19:45641772ENST00000438150-12355_3770666.0Zinc fingerC2H2-type 6
HgeneZNF28chr19:53321197chr19:45641772ENST00000438150-12383_4050666.0Zinc fingerC2H2-type 7
HgeneZNF28chr19:53321197chr19:45641772ENST00000438150-12411_4330666.0Zinc fingerC2H2-type 8
HgeneZNF28chr19:53321197chr19:45641772ENST00000438150-12439_4610666.0Zinc fingerC2H2-type 9
HgeneZNF28chr19:53321197chr19:45641772ENST00000438150-12467_4890666.0Zinc fingerC2H2-type 10
HgeneZNF28chr19:53321197chr19:45641772ENST00000438150-12495_5170666.0Zinc fingerC2H2-type 11
HgeneZNF28chr19:53321197chr19:45641772ENST00000438150-12523_5450666.0Zinc fingerC2H2-type 12
HgeneZNF28chr19:53321197chr19:45641772ENST00000438150-12551_5730666.0Zinc fingerC2H2-type 13
HgeneZNF28chr19:53321197chr19:45641772ENST00000438150-12579_6010666.0Zinc fingerC2H2-type 14
HgeneZNF28chr19:53321197chr19:45641772ENST00000438150-12607_6290666.0Zinc fingerC2H2-type 15
HgeneZNF28chr19:53321197chr19:45641772ENST00000438150-12635_6570666.0Zinc fingerC2H2-type 16
HgeneZNF28chr19:53321197chr19:45641772ENST00000438150-12663_6850666.0Zinc fingerC2H2-type 17
HgeneZNF28chr19:53321197chr19:45641772ENST00000438150-12691_7130666.0Zinc fingerC2H2-type 18
HgeneZNF28chr19:53321197chr19:45641772ENST00000457749-24215_2375719.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF28chr19:53321197chr19:45641772ENST00000457749-24243_2655719.0Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF28chr19:53321197chr19:45641772ENST00000457749-24271_2935719.0Zinc fingerC2H2-type 3
HgeneZNF28chr19:53321197chr19:45641772ENST00000457749-24299_3215719.0Zinc fingerC2H2-type 4%3B degenerate
HgeneZNF28chr19:53321197chr19:45641772ENST00000457749-24327_3495719.0Zinc fingerC2H2-type 5
HgeneZNF28chr19:53321197chr19:45641772ENST00000457749-24355_3775719.0Zinc fingerC2H2-type 6
HgeneZNF28chr19:53321197chr19:45641772ENST00000457749-24383_4055719.0Zinc fingerC2H2-type 7
HgeneZNF28chr19:53321197chr19:45641772ENST00000457749-24411_4335719.0Zinc fingerC2H2-type 8
HgeneZNF28chr19:53321197chr19:45641772ENST00000457749-24439_4615719.0Zinc fingerC2H2-type 9
HgeneZNF28chr19:53321197chr19:45641772ENST00000457749-24467_4895719.0Zinc fingerC2H2-type 10
HgeneZNF28chr19:53321197chr19:45641772ENST00000457749-24495_5175719.0Zinc fingerC2H2-type 11
HgeneZNF28chr19:53321197chr19:45641772ENST00000457749-24523_5455719.0Zinc fingerC2H2-type 12
HgeneZNF28chr19:53321197chr19:45641772ENST00000457749-24551_5735719.0Zinc fingerC2H2-type 13
HgeneZNF28chr19:53321197chr19:45641772ENST00000457749-24579_6015719.0Zinc fingerC2H2-type 14
HgeneZNF28chr19:53321197chr19:45641772ENST00000457749-24607_6295719.0Zinc fingerC2H2-type 15
HgeneZNF28chr19:53321197chr19:45641772ENST00000457749-24635_6575719.0Zinc fingerC2H2-type 16
HgeneZNF28chr19:53321197chr19:45641772ENST00000457749-24663_6855719.0Zinc fingerC2H2-type 17
HgeneZNF28chr19:53321197chr19:45641772ENST00000457749-24691_7135719.0Zinc fingerC2H2-type 18


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Fusion Gene Sequence for ZNF28-PPP1R37


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>101806_101806_1_ZNF28-PPP1R37_ZNF28_chr19_53321197_ENST00000457749_PPP1R37_chr19_45641772_ENST00000221462_length(transcript)=2732nt_BP=135nt
GACCAGGAAGCGGATCCCGTGGAATGACGGTGACGCCGCGGCGGGCGGATTGACTTCTAAAGAATCTTGGTACGTGAGGAAGAAACCCAG
AAGAGGAAGAGGAAAGCAAAGGAGTCAGGGATGGCTCTTCCTCAGCCCAGAATGTGACCGTGGACGAGGTCATCGGCGCCTACAAGCAGG
CCTGCCAGAAGCTGAACTGCAGGCAGATCCCCAAGCTCCTCAGGCAGCTGCAGGAATTCACAGACCTCGGGCACCGCCTCGACTGTCTGG
ACCTGAAAGGTGAGAAGCTTGACTACAAGACCTGTGAGGCCCTGGAAGAGGTCTTCAAGAGGCTGCAGTTCAAGGTCGTGGACCTGGAGC
AGACAAACCTGGATGAAGATGGTGCCTCGGCCCTCTTCGACATGATCGAGTACTACGAGTCGGCCACCCACCTCAACATCTCCTTCAACA
AGCACATCGGCACCCGGGGCTGGCAGGCGGCCGCCCACATGATGCGCAAGACGAGCTGCCTGCAGTATCTGGACGCCCGCAACACGCCCC
TGCTGGACCACTCGGCGCCCTTCGTGGCCCGTGCCCTGCGCATCCGCAGCAGCCTGGCAGTGCTGCACTTGGAGAACGCCAGCCTGTCGG
GGCGGCCCCTCATGCTGCTCGCCACGGCCCTGAAGATGAACATGAACCTGCGGGAGCTGTACCTGGCGGACAACAAGCTCAACGGCCTGC
AGGACTCGGCCCAGCTGGGTAACCTGCTCAAGTTCAACTGCTCCCTGCAGATCCTGGACCTCCGGAACAACCACGTGCTAGACTCGGGTC
TGGCCTACATCTGCGAGGGCCTCAAGGAGCAGAGGAAGGGGCTGGTGACCCTGGTGCTGTGGAACAACCAGCTCACGCACACAGGCATGG
CCTTCCTGGGCATGACACTGCCGCACACTCAGAGCCTGGAGACGCTGAACCTGGGCCACAACCCCATCGGGAACGAGGGTGTGCGGCACC
TCAAGAACGGGCTCATCAGCAACCGCAGCGTGCTGCGCCTCGGGCTGGCCTCCACCAAGCTCACGTGCGAGGGCGCGGTGGCGGTGGCGG
AGTTCATCGCTGAGAGCCCCCGCCTCCTGAGACTGGACCTTCGGGAGAACGAGATCAAGACAGGCGGGCTCATGGCACTGTCGTTGGCCC
TCAAGGTGAACCACTCACTGCTGCGCCTGGACCTCGACCGTGAACCCAAGAAAGAGGCGGTGAAGAGCTTCATCGAGACGCAGAAGGCGC
TGCTGGCCGAGATCCAGAACGGCTGCAAGCGCAACTTGGTGCTGGCGCGGGAGAGGGAGGAGAAGGAGCAGCCGCCACAGCTGTCGGCCT
CCATGCCTGAGACCACCGCCACCGAGCCCCAGCCCGACGACGAGCCCGCCGCTGGGGTGCAGAACGGGGCCCCCAGCCCCGCACCCAGCC
CGGACTCAGACTCAGACTCGGACTCGGATGGGGAGGAAGAGGAGGAAGAGGAAGGGGAGAGGGACGAGACCCCCTGTCCTGCCCTGGTGC
CCCCCACGGACTCCCTGGGCCCTGGGGACAGGAGTCCCCCAGGCAGCCCCTCCACACCCACCGAGCAGCGGATTTCCGTGTCCAGCCCGG
GCCGGGGCCACAAGGTGTTTGTGGTGACCCGGGTGGAGAGCCCGCCCGAGAGGGCAGAGCCCCCTGCGTCCCCCACCCCTCCCTCTCCCC
CACCCCCTCCCTCCCCACCCGCCTCACCTTCCCTACCACCAGCCGGGGCCATTGACACCCGGGACACAGGGTCCTCTGAGCCTCAGCCAC
CACCGGAGCCGCCTCGGTCAGGGCCACCACTGCCCAACGGCCTGAAGCCCGAGTTCGCCCTGGCACTGCCCCCTGAGCCGCCCCCGGGGC
CTGAGGTCAAGGGGGGCAGCTGCGGCCTGGAGCACGAACTGAGCTGCTCCAAGAACGAGAAGGAGCTCGAGGAGCTGCTTCTGGAAGCCA
GTCAGGAATCCGGGCAGGAGACACTGTGACACTTTAGTTCCCTTTTTCCGGTCGGTCTGCGATGAGCTGAGGCCAGAGCCATGAGAATCT
GCTCACCTTCCCCCCAGCCTTCCTGAGGCCCAGGATGCCAGGGGTGGGGGCCATTCTGGGGCCCCCCTCCCCCCACAGCAACACTACAAG
GGGTGCAGGAGCTACAGGGAGTGGCCCTCCGCGCGTGACTCAAGCACTTCTATTTATGAGCCCAGCACTGGAAGACTCTGGGGGTGAATG
GGAGGAGGGGGAGCAGGAGGAGGAGGAGGTCTCCAAGGACATCAGGCGCCTGTTCTGGAGGGGCCAGGCTTGCCCTGCGGAGGGCAGGCG
TCCTGGGTGGTGGTGGGATGGTCCCCTGTGGCCCCGGGCACAGGGCCGGGCAGGCAGCCTGGTGCCGGAGAGGCGGTGCGTGCTGGTGGT
GGTTGAGATGCACAGAACAGCCCCAGACAGCGCAGGCCGGGCAGGGTGGGGGGATGGGAGCAGAGGATCAGAGCTTTCTTTTTCTCAAGT
GCAATAAATCTATCAGGGAGCTGGGGCGGGAGCAGCCGGCACTCCGGGACCCTGCTGTCCAGGCCACTGGAGGCTGCGCCCTGAGAGGCA
CTACAGCCCTTTGGGGGCGAGTGGCATGGGTGTGGGTGAGGGTGGGCAGAGGGCTGGGGCTACTCCTGTCGGTGCAACTCTGTTCACACC

>101806_101806_1_ZNF28-PPP1R37_ZNF28_chr19_53321197_ENST00000457749_PPP1R37_chr19_45641772_ENST00000221462_length(amino acids)=605AA_BP=
MNCRQIPKLLRQLQEFTDLGHRLDCLDLKGEKLDYKTCEALEEVFKRLQFKVVDLEQTNLDEDGASALFDMIEYYESATHLNISFNKHIG
TRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSA
QLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNG
LISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDLDREPKKEAVKSFIETQKALLAE
IQNGCKRNLVLAREREEKEQPPQLSASMPETTATEPQPDDEPAAGVQNGAPSPAPSPDSDSDSDSDGEEEEEEEGERDETPCPALVPPTD
SLGPGDRSPPGSPSTPTEQRISVSSPGRGHKVFVVTRVESPPERAEPPASPTPPSPPPPPSPPASPSLPPAGAIDTRDTGSSEPQPPPEP

--------------------------------------------------------------
>101806_101806_2_ZNF28-PPP1R37_ZNF28_chr19_53321197_ENST00000457749_PPP1R37_chr19_45641772_ENST00000421905_length(transcript)=1997nt_BP=135nt
GACCAGGAAGCGGATCCCGTGGAATGACGGTGACGCCGCGGCGGGCGGATTGACTTCTAAAGAATCTTGGTACGTGAGGAAGAAACCCAG
AAGAGGAAGAGGAAAGCAAAGGAGTCAGGGATGGCTCTTCCTCAGCCCAGAATGTGACCGTGGACGAGGTCATCGGCGCCTACAAGCAGG
CCTGCCAGAAGCTGAACTGCAGGCAGATCCCCAAGCTCCTCAGGCAGCTGCAGGAATTCACAGACCTCGGGCACCGCCTCGACTGTCTGG
ACCTGAAAGGTGAGAAGCTTGACTACAAGACCTGTGAGGCCCTGGAAGAGGTCTTCAAGAGGCTGCAGTTCAAGGTCGTGGACCTGGAGC
AGACAAACCTGGATGAAGATGGTGCCTCGGCCCTCTTCGACATGATCGAGTACTACGAGTCGGCCACCCACCTCAACATCTCCTTCAACA
AGCACATCGGCACCCGGGGCTGGCAGGCGGCCGCCCACATGATGCGCAAGACGAGCTGCCTGCAGTATCTGGACGCCCGCAACACGCCCC
TGCTGGACCACTCGGCGCCCTTCGTGGCCCGTGCCCTGCGCATCCGCAGCAGCCTGGCAGTGCTGCACTTGGAGAACGCCAGCCTGTCGG
GGCGGCCCCTCATGCTGCTCGCCACGGCCCTGAAGATGAACATGAACCTGCGGGAGCTGTACCTGGCGGACAACAAGCTCAACGGCCTGC
AGGACTCGGCCCAGCTGGGTAACCTGCTCAAGTTCAACTGCTCCCTGCAGATCCTGGACCTCCGGAACAACCACGTGCTAGACTCGGGTC
TGGCCTACATCTGCGAGGGCCTCAAGGAGCAGAGGAAGGGGCTGGTGACCCTGGTGCTGTGGAACAACCAGCTCACGCACACAGGCATGG
CCTTCCTGGGCATGACACTGAGCCTGGAGACGCTGAACCTGGGCCACAACCCCATCGGGAACGAGGGTGTGCGGCACCTCAAGAACGGGC
TCATCAGCAACCGCAGCGTGCTGCGCCTCGGGCTGGCCTCCACCAAGCTCACGTGCGAGGGCGCGGTGGCGGTGGCGGAGTTCATCGCTG
AGAGCCCCCGCCTCCTGAGACTGGACCTTCGGGAGAACGAGATCAAGACAGGCGGGCTCATGGCACTGTCGTTGGCCCTCAAGGTGAACC
ACTCACTGCTGCGCCTGGACCTCGACCGTGAACCCAAGAAAGAGGCGGTGAAGAGCTTCATCGAGACGCAGAAGGCGCTGCTGGCCGAGA
TCCAGAACGGCTGCAAGCGCAACTTGGTGCTGGCGCGGGAGAGGGAGGAGAAGGAGCAGCCGCCACAGCTGTCGGCCTCCATGCCTGAGA
CCACCGCCACCGAGCCCCAGCCCGACGACGAGCCCGCCGCTGGGGTGCAGAACGGGGCCCCCAGCCCCGCACCCAGCCCGGACTCAGACT
CAGACTCGGACTCGGATGGGGAGGAAGAGGAGGAAGAGGAAGGGGAGAGGGACGAGACCCCCTGTCCTGCCCTGGTGCCCCCCACGGACT
CCCTGGGCCCTGGGGACAGGAGTCCCCCAGGCAGCCCCTCCACACCCACCGAGCAGCGGATTTCCGTGTCCAGCCCGGGCCGGGGCCACA
AGGTGTTTGTGGTGACCCGGGTGGAGAGCCCGCCCGAGAGGGCAGAGCCCCCTGCGTCCCCCACCCCTCCCTCTCCCCCACCCCCTCCCT
CCCCACCCGCCTCACCTTCCCTACCACCAGCCGGGGCCATTGACACCCGGGACACAGGGTCCTCTGAGCCTCAGCCACCACCGGAGCCGC
CTCGGTCAGGGCCACCACTGCCCAACGGCCTGAAGCCCGAGTTCGCCCTGGCACTGCCCCCTGAGCCGCCCCCGGGGCCTGAGGTCAAGG
GGGGCAGCTGCGGCCTGGAGCACGAACTGAGCTGCTCCAAGAACGAGAAGGAGCTCGAGGAGCTGCTTCTGGAAGCCAGTCAGGAATCCG

>101806_101806_2_ZNF28-PPP1R37_ZNF28_chr19_53321197_ENST00000457749_PPP1R37_chr19_45641772_ENST00000421905_length(amino acids)=602AA_BP=
MNCRQIPKLLRQLQEFTDLGHRLDCLDLKGEKLDYKTCEALEEVFKRLQFKVVDLEQTNLDEDGASALFDMIEYYESATHLNISFNKHIG
TRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSA
QLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLSLETLNLGHNPIGNEGVRHLKNGLISN
RSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDLDREPKKEAVKSFIETQKALLAEIQNG
CKRNLVLAREREEKEQPPQLSASMPETTATEPQPDDEPAAGVQNGAPSPAPSPDSDSDSDSDGEEEEEEEGERDETPCPALVPPTDSLGP
GDRSPPGSPSTPTEQRISVSSPGRGHKVFVVTRVESPPERAEPPASPTPPSPPPPPSPPASPSLPPAGAIDTRDTGSSEPQPPPEPPRSG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZNF28-PPP1R37


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF28-PPP1R37


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF28-PPP1R37


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource