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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF292-ORC3 (FusionGDB2 ID:101825)

Fusion Gene Summary for ZNF292-ORC3

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF292-ORC3
Fusion gene ID: 101825
HgeneTgene
Gene symbol

ZNF292

ORC3

Gene ID

23036

23595

Gene namezinc finger protein 292origin recognition complex subunit 3
SynonymsNbla00365|ZFP292|ZN-16|Zn-15|bA393I2.3LAT|LATHEO|ORC3L
Cytomap

6q14.3

6q15

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 29216 zinc-finger domain proteinputative protein product of Nbla00365origin recognition complex subunit 3homolog of latheo, Drosophilaorigin recognition complex subunit Latheoorigin recognition complex, subunit 3 honolog
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000369578, ENST00000339907, 
ENST00000369577, ENST00000392985, 
ENST00000257789, ENST00000392844, 
ENST00000417380, ENST00000546266, 
ENST00000478028, 
Fusion gene scores* DoF score24 X 7 X 12=20163 X 3 X 4=36
# samples 274
** MAII scorelog2(27/2016*10)=-2.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZNF292 [Title/Abstract] AND ORC3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF292(87865477)-ORC3(88362834), # samples:2
Anticipated loss of major functional domain due to fusion event.ZNF292-ORC3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ZNF292-ORC3 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ZNF292-ORC3 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
ZNF292-ORC3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneORC3

GO:0006275

regulation of DNA replication

31160578


check buttonFusion gene breakpoints across ZNF292 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ORC3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-MF-A522ZNF292chr6

87865477

+ORC3chr6

88362834

+
ChimerDB4UCSTCGA-N5-A4R8ZNF292chr6

87862587

+ORC3chr6

88344563

+
ChimerDB4UCSTCGA-N5-A4R8ZNF292chr6

87865477

+ORC3chr6

88344563

+
ChimerDB4UCSTCGA-N5-A4R8ZNF292chr6

87865477

+ORC3chr6

88362834

+


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Fusion Gene ORF analysis for ZNF292-ORC3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000369578ENST00000257789ZNF292chr6

87865477

+ORC3chr6

88362834

+
3UTR-3CDSENST00000369578ENST00000257789ZNF292chr6

87865477

+ORC3chr6

88344563

+
3UTR-3CDSENST00000369578ENST00000392844ZNF292chr6

87865477

+ORC3chr6

88362834

+
3UTR-3CDSENST00000369578ENST00000392844ZNF292chr6

87865477

+ORC3chr6

88344563

+
3UTR-3CDSENST00000369578ENST00000417380ZNF292chr6

87865477

+ORC3chr6

88344563

+
3UTR-3CDSENST00000369578ENST00000546266ZNF292chr6

87865477

+ORC3chr6

88362834

+
3UTR-3CDSENST00000369578ENST00000546266ZNF292chr6

87865477

+ORC3chr6

88344563

+
3UTR-3UTRENST00000369578ENST00000417380ZNF292chr6

87865477

+ORC3chr6

88362834

+
3UTR-intronENST00000369578ENST00000478028ZNF292chr6

87865477

+ORC3chr6

88362834

+
3UTR-intronENST00000369578ENST00000478028ZNF292chr6

87865477

+ORC3chr6

88344563

+
5CDS-3UTRENST00000339907ENST00000417380ZNF292chr6

87865477

+ORC3chr6

88362834

+
5CDS-3UTRENST00000369577ENST00000417380ZNF292chr6

87865477

+ORC3chr6

88362834

+
5CDS-3UTRENST00000392985ENST00000417380ZNF292chr6

87865477

+ORC3chr6

88362834

+
5CDS-intronENST00000339907ENST00000478028ZNF292chr6

87865477

+ORC3chr6

88362834

+
5CDS-intronENST00000339907ENST00000478028ZNF292chr6

87865477

+ORC3chr6

88344563

+
5CDS-intronENST00000369577ENST00000478028ZNF292chr6

87865477

+ORC3chr6

88362834

+
5CDS-intronENST00000369577ENST00000478028ZNF292chr6

87865477

+ORC3chr6

88344563

+
5CDS-intronENST00000392985ENST00000478028ZNF292chr6

87865477

+ORC3chr6

88362834

+
5CDS-intronENST00000392985ENST00000478028ZNF292chr6

87865477

+ORC3chr6

88344563

+
5UTR-3CDSENST00000392985ENST00000257789ZNF292chr6

87862587

+ORC3chr6

88344563

+
5UTR-3CDSENST00000392985ENST00000392844ZNF292chr6

87862587

+ORC3chr6

88344563

+
5UTR-3CDSENST00000392985ENST00000417380ZNF292chr6

87862587

+ORC3chr6

88344563

+
5UTR-3CDSENST00000392985ENST00000546266ZNF292chr6

87862587

+ORC3chr6

88344563

+
5UTR-intronENST00000392985ENST00000478028ZNF292chr6

87862587

+ORC3chr6

88344563

+
Frame-shiftENST00000339907ENST00000257789ZNF292chr6

87865477

+ORC3chr6

88362834

+
Frame-shiftENST00000339907ENST00000392844ZNF292chr6

87865477

+ORC3chr6

88362834

+
Frame-shiftENST00000339907ENST00000546266ZNF292chr6

87865477

+ORC3chr6

88362834

+
Frame-shiftENST00000369577ENST00000257789ZNF292chr6

87865477

+ORC3chr6

88362834

+
Frame-shiftENST00000369577ENST00000392844ZNF292chr6

87865477

+ORC3chr6

88362834

+
Frame-shiftENST00000369577ENST00000546266ZNF292chr6

87865477

+ORC3chr6

88362834

+
Frame-shiftENST00000392985ENST00000257789ZNF292chr6

87865477

+ORC3chr6

88362834

+
Frame-shiftENST00000392985ENST00000392844ZNF292chr6

87865477

+ORC3chr6

88362834

+
Frame-shiftENST00000392985ENST00000546266ZNF292chr6

87865477

+ORC3chr6

88362834

+
In-frameENST00000339907ENST00000257789ZNF292chr6

87865477

+ORC3chr6

88344563

+
In-frameENST00000339907ENST00000392844ZNF292chr6

87865477

+ORC3chr6

88344563

+
In-frameENST00000339907ENST00000417380ZNF292chr6

87865477

+ORC3chr6

88344563

+
In-frameENST00000339907ENST00000546266ZNF292chr6

87865477

+ORC3chr6

88344563

+
In-frameENST00000369577ENST00000257789ZNF292chr6

87865477

+ORC3chr6

88344563

+
In-frameENST00000369577ENST00000392844ZNF292chr6

87865477

+ORC3chr6

88344563

+
In-frameENST00000369577ENST00000417380ZNF292chr6

87865477

+ORC3chr6

88344563

+
In-frameENST00000369577ENST00000546266ZNF292chr6

87865477

+ORC3chr6

88344563

+
In-frameENST00000392985ENST00000257789ZNF292chr6

87865477

+ORC3chr6

88344563

+
In-frameENST00000392985ENST00000392844ZNF292chr6

87865477

+ORC3chr6

88344563

+
In-frameENST00000392985ENST00000417380ZNF292chr6

87865477

+ORC3chr6

88344563

+
In-frameENST00000392985ENST00000546266ZNF292chr6

87865477

+ORC3chr6

88344563

+
intron-3CDSENST00000339907ENST00000257789ZNF292chr6

87862587

+ORC3chr6

88344563

+
intron-3CDSENST00000339907ENST00000392844ZNF292chr6

87862587

+ORC3chr6

88344563

+
intron-3CDSENST00000339907ENST00000417380ZNF292chr6

87862587

+ORC3chr6

88344563

+
intron-3CDSENST00000339907ENST00000546266ZNF292chr6

87862587

+ORC3chr6

88344563

+
intron-3CDSENST00000369577ENST00000257789ZNF292chr6

87862587

+ORC3chr6

88344563

+
intron-3CDSENST00000369577ENST00000392844ZNF292chr6

87862587

+ORC3chr6

88344563

+
intron-3CDSENST00000369577ENST00000417380ZNF292chr6

87862587

+ORC3chr6

88344563

+
intron-3CDSENST00000369577ENST00000546266ZNF292chr6

87862587

+ORC3chr6

88344563

+
intron-3CDSENST00000369578ENST00000257789ZNF292chr6

87862587

+ORC3chr6

88344563

+
intron-3CDSENST00000369578ENST00000392844ZNF292chr6

87862587

+ORC3chr6

88344563

+
intron-3CDSENST00000369578ENST00000417380ZNF292chr6

87862587

+ORC3chr6

88344563

+
intron-3CDSENST00000369578ENST00000546266ZNF292chr6

87862587

+ORC3chr6

88344563

+
intron-intronENST00000339907ENST00000478028ZNF292chr6

87862587

+ORC3chr6

88344563

+
intron-intronENST00000369577ENST00000478028ZNF292chr6

87862587

+ORC3chr6

88344563

+
intron-intronENST00000369578ENST00000478028ZNF292chr6

87862587

+ORC3chr6

88344563

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000369577ZNF292chr687865477+ENST00000392844ORC3chr688344563+1490211431161372
ENST00000369577ZNF292chr687865477+ENST00000257789ORC3chr688344563+1493211431164373
ENST00000369577ZNF292chr687865477+ENST00000546266ORC3chr688344563+1204211431161372
ENST00000369577ZNF292chr687865477+ENST00000417380ORC3chr688344563+98021143519158
ENST00000339907ZNF292chr687865477+ENST00000392844ORC3chr688344563+1458179111129372
ENST00000339907ZNF292chr687865477+ENST00000257789ORC3chr688344563+1461179111132373
ENST00000339907ZNF292chr687865477+ENST00000546266ORC3chr688344563+1172179111129372
ENST00000339907ZNF292chr687865477+ENST00000417380ORC3chr688344563+94817911487158
ENST00000392985ZNF292chr687865477+ENST00000392844ORC3chr688344563+16844052371355372
ENST00000392985ZNF292chr687865477+ENST00000257789ORC3chr688344563+16874052371358373
ENST00000392985ZNF292chr687865477+ENST00000546266ORC3chr688344563+13984052371355372
ENST00000392985ZNF292chr687865477+ENST00000417380ORC3chr688344563+1174405237713158

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000369577ENST00000392844ZNF292chr687865477+ORC3chr688344563+0.0023797420.9976203
ENST00000369577ENST00000257789ZNF292chr687865477+ORC3chr688344563+0.0022272820.99777263
ENST00000369577ENST00000546266ZNF292chr687865477+ORC3chr688344563+0.0044215640.99557847
ENST00000369577ENST00000417380ZNF292chr687865477+ORC3chr688344563+0.0093300590.99066997
ENST00000339907ENST00000392844ZNF292chr687865477+ORC3chr688344563+0.0025673840.99743265
ENST00000339907ENST00000257789ZNF292chr687865477+ORC3chr688344563+0.0024218520.9975782
ENST00000339907ENST00000546266ZNF292chr687865477+ORC3chr688344563+0.004287650.9957124
ENST00000339907ENST00000417380ZNF292chr687865477+ORC3chr688344563+0.0102309290.9897691
ENST00000392985ENST00000392844ZNF292chr687865477+ORC3chr688344563+0.0022348450.9977652
ENST00000392985ENST00000257789ZNF292chr687865477+ORC3chr688344563+0.0021297910.9978702
ENST00000392985ENST00000546266ZNF292chr687865477+ORC3chr688344563+0.0038648980.9961351
ENST00000392985ENST00000417380ZNF292chr687865477+ORC3chr688344563+0.0092929870.99070704

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Fusion Genomic Features for ZNF292-ORC3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ZNF292chr687862587+ORC3chr688344562+0.035155140.9648448
ZNF292chr687865477+ORC3chr688344562+4.59E-070.9999995
ZNF292chr687865477+ORC3chr688362833+7.07E-091
ZNF292chr687865477+ORC3chr688362833+7.07E-091
ZNF292chr687862587+ORC3chr688344562+0.035155140.9648448
ZNF292chr687865477+ORC3chr688344562+4.59E-070.9999995
ZNF292chr687865477+ORC3chr688362833+7.07E-091
ZNF292chr687865477+ORC3chr688362833+7.07E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ZNF292-ORC3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:87865477/chr6:88362834)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF292chr6:87865477chr6:88344563ENST00000369577+181827_1854562724.0Coiled coilOntology_term=ECO:0000255
HgeneZNF292chr6:87865477chr6:88344563ENST00000369577+181098_1123562724.0Zinc fingerC2H2-type 7
HgeneZNF292chr6:87865477chr6:88344563ENST00000369577+181375_1397562724.0Zinc fingerC2H2-type 8%3B degenerate
HgeneZNF292chr6:87865477chr6:88344563ENST00000369577+181902_1927562724.0Zinc fingerC2H2-type 9
HgeneZNF292chr6:87865477chr6:88344563ENST00000369577+181947_1972562724.0Zinc fingerC2H2-type 10
HgeneZNF292chr6:87865477chr6:88344563ENST00000369577+182114_2139562724.0Zinc fingerC2H2-type 11
HgeneZNF292chr6:87865477chr6:88344563ENST00000369577+182172_2197562724.0Zinc fingerC2H2-type 12
HgeneZNF292chr6:87865477chr6:88344563ENST00000369577+182216_2241562724.0Zinc fingerC2H2-type 13
HgeneZNF292chr6:87865477chr6:88344563ENST00000369577+182256_2281562724.0Zinc fingerC2H2-type 14
HgeneZNF292chr6:87865477chr6:88344563ENST00000369577+182386_2410562724.0Zinc fingerC2H2-type 15
HgeneZNF292chr6:87865477chr6:88344563ENST00000369577+18569_591562724.0Zinc fingerC2H2-type 1
HgeneZNF292chr6:87865477chr6:88344563ENST00000369577+18681_705562724.0Zinc fingerC2H2-type 2
HgeneZNF292chr6:87865477chr6:88344563ENST00000369577+18722_744562724.0Zinc fingerC2H2-type 3
HgeneZNF292chr6:87865477chr6:88344563ENST00000369577+18750_774562724.0Zinc fingerC2H2-type 4
HgeneZNF292chr6:87865477chr6:88344563ENST00000369577+18779_803562724.0Zinc fingerC2H2-type 5
HgeneZNF292chr6:87865477chr6:88344563ENST00000369577+18807_831562724.0Zinc fingerC2H2-type 6


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Fusion Gene Sequence for ZNF292-ORC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>101825_101825_1_ZNF292-ORC3_ZNF292_chr6_87865477_ENST00000339907_ORC3_chr6_88344563_ENST00000257789_length(transcript)=1461nt_BP=179nt
GGGGTGTGAAGATGGCGGACGAAGAGGCCGAGCAGGAGAGGTTGAGTTGCGGCGAAGGCGGCTGCGTCGCGGAGCTGCAGCGCCTGGGCG
AGCGGCTCCAGGAGCTGGAGCTACAGCTGCGGGAGAGCCGGGTACCGGCCGTGGAAGCGGCCACCGACTACTGTCAGCAGCTGTGCCAGG
AGGAAACACAATTATTACTAGAAAACCTGCATGTTTATCATATGAATTACTTCCTGGTTTTGAGATGTCTTCATAAGTTCACCTCTTCTC
TTCCCAAGTATCCACTAGGTCGACAGATCAGAGAGTTGTACTGTACATGTTTAGAAAAGAACATATGGGATTCAGAGGAGTATGCATCAG
TCTTGCAGCTGCTGAGGATGTTGGCAAAGGATGAACTGATGACCATACTTGAGAAATGTTTCAAGGTTTTTAAGTCTTATTGTGAAAACC
ACCTTGGCAGCACAGCTAAGAGAATAGAGGAGTTCCTGGCCCAGTTTCAGAGCCTCGATGCAGAAACCAAAGAGGAAGAAGATGCTTCTG
GGTCACAGCCAAAGGGGCTTCAGAAGACAGACCTCTATCATCTTCAGAAGTCCTTATTGGAAATGAAGGAGTTAAGAAGAAGTAAGAAGC
AAACCAAATTTGAAGTACTCAGAGAAAATGTTGTGAACTTCATTGACTGTCTAGTGAGAGAATACCTTCTGCCTCCTGAGACACAGCCTC
TCCATGAGGTGGTGTACTTCAGTGCTGCCCATGCCCTTCGTGAGCATTTAAATGCTGCTCCGCGAATTGCCCTCCATACTGCACTCAACA
ATCCTTACTATTATCTCAAGAATGAAGCACTGAAAAGCGAAGAAGGCTGCATTCCGAATATCGCCCCAGACATCTGCATAGCATACAAAC
TGCACCTAGAGTGTAGCAGGCTCATCAACCTCGTGGACTGGTCAGAGGCTTTTGCAACAGTTGTGACAGCTGCTGAAAAAATGGATGCAA
ATTCTGCAACCTCAGAAGAAATGAATGAAATTATCCATGCTCGGTTTATTAGAGCTGTTTCTGAACTAGAACTTTTAGGATTTATAAAAC
CTACCAAACAGAAGACTGACCATGTGGCAAGACTAACATGGGGAGGCTGCTAGAAAGCAAATAAGCAAAGCCAGAACTATCACATTTAGC
TTAAGAGAAAAAGGTGACCAGTCATATTTACATATATTAGAGGAGCCTGTTTTGTTGAGAAGATAAATGTGTAACCCCCATTGATGTTTA
ACCAGAAAAGTACATTGCTAACCCCAAACAGGCATGTATCAAAACACCTGTGGAGTACTTTAGACTCCAACAAATAATAATGTAACTAAA
ACTGCTCACACATTTTACTGTACTTTCCAAAGTCATTACTAAATTGTGAGTAAATCATTCTTGAACTTAGAGTATGTAAATGTAATAAAT

>101825_101825_1_ZNF292-ORC3_ZNF292_chr6_87865477_ENST00000339907_ORC3_chr6_88344563_ENST00000257789_length(amino acids)=373AA_BP=0
MADEEAEQERLSCGEGGCVAELQRLGERLQELELQLRESRVPAVEAATDYCQQLCQEETQLLLENLHVYHMNYFLVLRCLHKFTSSLPKY
PLGRQIRELYCTCLEKNIWDSEEYASVLQLLRMLAKDELMTILEKCFKVFKSYCENHLGSTAKRIEEFLAQFQSLDAETKEEEDASGSQP
KGLQKTDLYHLQKSLLEMKELRRSKKQTKFEVLRENVVNFIDCLVREYLLPPETQPLHEVVYFSAAHALREHLNAAPRIALHTALNNPYY
YLKNEALKSEEGCIPNIAPDICIAYKLHLECSRLINLVDWSEAFATVVTAAEKMDANSATSEEMNEIIHARFIRAVSELELLGFIKPTKQ

--------------------------------------------------------------
>101825_101825_2_ZNF292-ORC3_ZNF292_chr6_87865477_ENST00000339907_ORC3_chr6_88344563_ENST00000392844_length(transcript)=1458nt_BP=179nt
GGGGTGTGAAGATGGCGGACGAAGAGGCCGAGCAGGAGAGGTTGAGTTGCGGCGAAGGCGGCTGCGTCGCGGAGCTGCAGCGCCTGGGCG
AGCGGCTCCAGGAGCTGGAGCTACAGCTGCGGGAGAGCCGGGTACCGGCCGTGGAAGCGGCCACCGACTACTGTCAGCAGCTGTGCCAGG
AGGAAACACAATTATTACTAGAAAACCTGCATGTTTATCATATGAATTACTTCCTGGTTTTGAGATGTCTTCATAAGTTCACCTCTTCTC
TTCCCAAGTATCCACTAGGTCGACAGATCAGAGAGTTGTACTGTACATGTTTAGAAAAGAACATATGGGATTCAGAGGAGTATGCATCAG
TCTTGCAGCTGCTGAGGATGTTGGCAAAGGATGAACTGATGACCATACTTGAGAAATGTTTCAAGGTTTTTAAGTCTTATTGTGAAAACC
ACCTTGGCAGCACAGCTAAGAGAATAGAGGAGTTCCTGGCCCAGTTTCAGAGCCTCGATGAAACCAAAGAGGAAGAAGATGCTTCTGGGT
CACAGCCAAAGGGGCTTCAGAAGACAGACCTCTATCATCTTCAGAAGTCCTTATTGGAAATGAAGGAGTTAAGAAGAAGTAAGAAGCAAA
CCAAATTTGAAGTACTCAGAGAAAATGTTGTGAACTTCATTGACTGTCTAGTGAGAGAATACCTTCTGCCTCCTGAGACACAGCCTCTCC
ATGAGGTGGTGTACTTCAGTGCTGCCCATGCCCTTCGTGAGCATTTAAATGCTGCTCCGCGAATTGCCCTCCATACTGCACTCAACAATC
CTTACTATTATCTCAAGAATGAAGCACTGAAAAGCGAAGAAGGCTGCATTCCGAATATCGCCCCAGACATCTGCATAGCATACAAACTGC
ACCTAGAGTGTAGCAGGCTCATCAACCTCGTGGACTGGTCAGAGGCTTTTGCAACAGTTGTGACAGCTGCTGAAAAAATGGATGCAAATT
CTGCAACCTCAGAAGAAATGAATGAAATTATCCATGCTCGGTTTATTAGAGCTGTTTCTGAACTAGAACTTTTAGGATTTATAAAACCTA
CCAAACAGAAGACTGACCATGTGGCAAGACTAACATGGGGAGGCTGCTAGAAAGCAAATAAGCAAAGCCAGAACTATCACATTTAGCTTA
AGAGAAAAAGGTGACCAGTCATATTTACATATATTAGAGGAGCCTGTTTTGTTGAGAAGATAAATGTGTAACCCCCATTGATGTTTAACC
AGAAAAGTACATTGCTAACCCCAAACAGGCATGTATCAAAACACCTGTGGAGTACTTTAGACTCCAACAAATAATAATGTAACTAAAACT
GCTCACACATTTTACTGTACTTTCCAAAGTCATTACTAAATTGTGAGTAAATCATTCTTGAACTTAGAGTATGTAAATGTAATAAATTCC

>101825_101825_2_ZNF292-ORC3_ZNF292_chr6_87865477_ENST00000339907_ORC3_chr6_88344563_ENST00000392844_length(amino acids)=372AA_BP=0
MADEEAEQERLSCGEGGCVAELQRLGERLQELELQLRESRVPAVEAATDYCQQLCQEETQLLLENLHVYHMNYFLVLRCLHKFTSSLPKY
PLGRQIRELYCTCLEKNIWDSEEYASVLQLLRMLAKDELMTILEKCFKVFKSYCENHLGSTAKRIEEFLAQFQSLDETKEEEDASGSQPK
GLQKTDLYHLQKSLLEMKELRRSKKQTKFEVLRENVVNFIDCLVREYLLPPETQPLHEVVYFSAAHALREHLNAAPRIALHTALNNPYYY
LKNEALKSEEGCIPNIAPDICIAYKLHLECSRLINLVDWSEAFATVVTAAEKMDANSATSEEMNEIIHARFIRAVSELELLGFIKPTKQK

--------------------------------------------------------------
>101825_101825_3_ZNF292-ORC3_ZNF292_chr6_87865477_ENST00000339907_ORC3_chr6_88344563_ENST00000417380_length(transcript)=948nt_BP=179nt
GGGGTGTGAAGATGGCGGACGAAGAGGCCGAGCAGGAGAGGTTGAGTTGCGGCGAAGGCGGCTGCGTCGCGGAGCTGCAGCGCCTGGGCG
AGCGGCTCCAGGAGCTGGAGCTACAGCTGCGGGAGAGCCGGGTACCGGCCGTGGAAGCGGCCACCGACTACTGTCAGCAGCTGTGCCAGG
AGGAAACACAATTATTACTAGAAAACCTGCATGTTTATCATATGAATTACTTCCTGGTTTTGAGATGTCTTCATAAGTTCACCTCTTCTC
TTCCCAAGTATCCACTAGGTCGACAGATCAGAGAGTTGTACTGTACATGTTTAGAAAAGAACATATGGGATTCAGAGGAGTATGCATCAG
TCTTGCAGCTGCTGAGGCTAGGTTTGGCCTTCCTTGATATTCAGTTATTTGGAGCTCAAAGTGGACAAGAGCTGTTGCTGCCCCTATCCT
GGGAAGCTAATCCTTCACATGCTGCTAACTTGGGTTAGATCTTCTGCCAGCAGAACCTCACCCGTCTTTCCCCTCCAAGCAAGTCAGTGC
CGGTGATTCCTTGGACACCAGAAATGCTAATCTTGTCTATTTGAATAGGCCTAAAGGATGTTGGCAAAGGATGAACTGATGACCATACTT
GAGAAATGTTTCAAGGTTTTTAAGTCTTATTGTGAAAACCACCTTGGCAGCACAGCTAAGAGAATAGAGGAGTTCCTGGCCCAGTTTCAG
AGCCTCGATGCAGAAACCAAAGAGGAAGAAGATGCTTCTGGGTCACAGCCAAAGGGGCTTCAGAAGACAGACCTCTATCATCTTCAGAAG
TCCTTATTGGAAATGAAGGAGTTAAGAAGAAGTAAGAAGCAAACCAAATTTGAAGTACTCAGAGAAAATGTTGTGAACTTCATTGACTGT

>101825_101825_3_ZNF292-ORC3_ZNF292_chr6_87865477_ENST00000339907_ORC3_chr6_88344563_ENST00000417380_length(amino acids)=158AA_BP=0
MADEEAEQERLSCGEGGCVAELQRLGERLQELELQLRESRVPAVEAATDYCQQLCQEETQLLLENLHVYHMNYFLVLRCLHKFTSSLPKY

--------------------------------------------------------------
>101825_101825_4_ZNF292-ORC3_ZNF292_chr6_87865477_ENST00000339907_ORC3_chr6_88344563_ENST00000546266_length(transcript)=1172nt_BP=179nt
GGGGTGTGAAGATGGCGGACGAAGAGGCCGAGCAGGAGAGGTTGAGTTGCGGCGAAGGCGGCTGCGTCGCGGAGCTGCAGCGCCTGGGCG
AGCGGCTCCAGGAGCTGGAGCTACAGCTGCGGGAGAGCCGGGTACCGGCCGTGGAAGCGGCCACCGACTACTGTCAGCAGCTGTGCCAGG
AGGAAACACAATTATTACTAGAAAACCTGCATGTTTATCATATGAATTACTTCCTGGTTTTGAGATGTCTTCATAAGTTCACCTCTTCTC
TTCCCAAGTATCCACTAGGTCGACAGATCAGAGAGTTGTACTGTACATGTTTAGAAAAGAACATATGGGATTCAGAGGAGTATGCATCAG
TCTTGCAGCTGCTGAGGATGTTGGCAAAGGATGAACTGATGACCATACTTGAGAAATGTTTCAAGGTTTTTAAGTCTTATTGTGAAAACC
ACCTTGGCAGCACAGCTAAGAGAATAGAGGAGTTCCTGGCCCAGTTTCAGAGCCTCGATGAAACCAAAGAGGAAGAAGATGCTTCTGGGT
CACAGCCAAAGGGGCTTCAGAAGACAGACCTCTATCATCTTCAGAAGTCCTTATTGGAAATGAAGGAGTTAAGAAGAAGTAAGAAGCAAA
CCAAATTTGAAGTACTCAGAGAAAATGTTGTGAACTTCATTGACTGTCTAGTGAGAGAATACCTTCTGCCTCCTGAGACACAGCCTCTCC
ATGAGGTGGTGTACTTCAGTGCTGCCCATGCCCTTCGTGAGCATTTAAATGCTGCTCCGCGAATTGCCCTCCATACTGCACTCAACAATC
CTTACTATTATCTCAAGAATGAAGCACTGAAAAGCGAAGAAGGCTGCATTCCGAATATCGCCCCAGACATCTGCATAGCATACAAACTGC
ACCTAGAGTGTAGCAGGCTCATCAACCTCGTGGACTGGTCAGAGGCTTTTGCAACAGTTGTGACAGCTGCTGAAAAAATGGATGCAAATT
CTGCAACCTCAGAAGAAATGAATGAAATTATCCATGCTCGGTTTATTAGAGCTGTTTCTGAACTAGAACTTTTAGGATTTATAAAACCTA
CCAAACAGAAGACTGACCATGTGGCAAGACTAACATGGGGAGGCTGCTAGAAAGCAAATAAGCAAAGCCAGAACTATCACATTTAGCTTA

>101825_101825_4_ZNF292-ORC3_ZNF292_chr6_87865477_ENST00000339907_ORC3_chr6_88344563_ENST00000546266_length(amino acids)=372AA_BP=0
MADEEAEQERLSCGEGGCVAELQRLGERLQELELQLRESRVPAVEAATDYCQQLCQEETQLLLENLHVYHMNYFLVLRCLHKFTSSLPKY
PLGRQIRELYCTCLEKNIWDSEEYASVLQLLRMLAKDELMTILEKCFKVFKSYCENHLGSTAKRIEEFLAQFQSLDETKEEEDASGSQPK
GLQKTDLYHLQKSLLEMKELRRSKKQTKFEVLRENVVNFIDCLVREYLLPPETQPLHEVVYFSAAHALREHLNAAPRIALHTALNNPYYY
LKNEALKSEEGCIPNIAPDICIAYKLHLECSRLINLVDWSEAFATVVTAAEKMDANSATSEEMNEIIHARFIRAVSELELLGFIKPTKQK

--------------------------------------------------------------
>101825_101825_5_ZNF292-ORC3_ZNF292_chr6_87865477_ENST00000369577_ORC3_chr6_88344563_ENST00000257789_length(transcript)=1493nt_BP=211nt
ATCACGTGACCCAGGTGCGTACGCGACGGAGCGGGGTGTGAAGATGGCGGACGAAGAGGCCGAGCAGGAGAGGTTGAGTTGCGGCGAAGG
CGGCTGCGTCGCGGAGCTGCAGCGCCTGGGCGAGCGGCTCCAGGAGCTGGAGCTACAGCTGCGGGAGAGCCGGGTACCGGCCGTGGAAGC
GGCCACCGACTACTGTCAGCAGCTGTGCCAGGAGGAAACACAATTATTACTAGAAAACCTGCATGTTTATCATATGAATTACTTCCTGGT
TTTGAGATGTCTTCATAAGTTCACCTCTTCTCTTCCCAAGTATCCACTAGGTCGACAGATCAGAGAGTTGTACTGTACATGTTTAGAAAA
GAACATATGGGATTCAGAGGAGTATGCATCAGTCTTGCAGCTGCTGAGGATGTTGGCAAAGGATGAACTGATGACCATACTTGAGAAATG
TTTCAAGGTTTTTAAGTCTTATTGTGAAAACCACCTTGGCAGCACAGCTAAGAGAATAGAGGAGTTCCTGGCCCAGTTTCAGAGCCTCGA
TGCAGAAACCAAAGAGGAAGAAGATGCTTCTGGGTCACAGCCAAAGGGGCTTCAGAAGACAGACCTCTATCATCTTCAGAAGTCCTTATT
GGAAATGAAGGAGTTAAGAAGAAGTAAGAAGCAAACCAAATTTGAAGTACTCAGAGAAAATGTTGTGAACTTCATTGACTGTCTAGTGAG
AGAATACCTTCTGCCTCCTGAGACACAGCCTCTCCATGAGGTGGTGTACTTCAGTGCTGCCCATGCCCTTCGTGAGCATTTAAATGCTGC
TCCGCGAATTGCCCTCCATACTGCACTCAACAATCCTTACTATTATCTCAAGAATGAAGCACTGAAAAGCGAAGAAGGCTGCATTCCGAA
TATCGCCCCAGACATCTGCATAGCATACAAACTGCACCTAGAGTGTAGCAGGCTCATCAACCTCGTGGACTGGTCAGAGGCTTTTGCAAC
AGTTGTGACAGCTGCTGAAAAAATGGATGCAAATTCTGCAACCTCAGAAGAAATGAATGAAATTATCCATGCTCGGTTTATTAGAGCTGT
TTCTGAACTAGAACTTTTAGGATTTATAAAACCTACCAAACAGAAGACTGACCATGTGGCAAGACTAACATGGGGAGGCTGCTAGAAAGC
AAATAAGCAAAGCCAGAACTATCACATTTAGCTTAAGAGAAAAAGGTGACCAGTCATATTTACATATATTAGAGGAGCCTGTTTTGTTGA
GAAGATAAATGTGTAACCCCCATTGATGTTTAACCAGAAAAGTACATTGCTAACCCCAAACAGGCATGTATCAAAACACCTGTGGAGTAC
TTTAGACTCCAACAAATAATAATGTAACTAAAACTGCTCACACATTTTACTGTACTTTCCAAAGTCATTACTAAATTGTGAGTAAATCAT

>101825_101825_5_ZNF292-ORC3_ZNF292_chr6_87865477_ENST00000369577_ORC3_chr6_88344563_ENST00000257789_length(amino acids)=373AA_BP=0
MADEEAEQERLSCGEGGCVAELQRLGERLQELELQLRESRVPAVEAATDYCQQLCQEETQLLLENLHVYHMNYFLVLRCLHKFTSSLPKY
PLGRQIRELYCTCLEKNIWDSEEYASVLQLLRMLAKDELMTILEKCFKVFKSYCENHLGSTAKRIEEFLAQFQSLDAETKEEEDASGSQP
KGLQKTDLYHLQKSLLEMKELRRSKKQTKFEVLRENVVNFIDCLVREYLLPPETQPLHEVVYFSAAHALREHLNAAPRIALHTALNNPYY
YLKNEALKSEEGCIPNIAPDICIAYKLHLECSRLINLVDWSEAFATVVTAAEKMDANSATSEEMNEIIHARFIRAVSELELLGFIKPTKQ

--------------------------------------------------------------
>101825_101825_6_ZNF292-ORC3_ZNF292_chr6_87865477_ENST00000369577_ORC3_chr6_88344563_ENST00000392844_length(transcript)=1490nt_BP=211nt
ATCACGTGACCCAGGTGCGTACGCGACGGAGCGGGGTGTGAAGATGGCGGACGAAGAGGCCGAGCAGGAGAGGTTGAGTTGCGGCGAAGG
CGGCTGCGTCGCGGAGCTGCAGCGCCTGGGCGAGCGGCTCCAGGAGCTGGAGCTACAGCTGCGGGAGAGCCGGGTACCGGCCGTGGAAGC
GGCCACCGACTACTGTCAGCAGCTGTGCCAGGAGGAAACACAATTATTACTAGAAAACCTGCATGTTTATCATATGAATTACTTCCTGGT
TTTGAGATGTCTTCATAAGTTCACCTCTTCTCTTCCCAAGTATCCACTAGGTCGACAGATCAGAGAGTTGTACTGTACATGTTTAGAAAA
GAACATATGGGATTCAGAGGAGTATGCATCAGTCTTGCAGCTGCTGAGGATGTTGGCAAAGGATGAACTGATGACCATACTTGAGAAATG
TTTCAAGGTTTTTAAGTCTTATTGTGAAAACCACCTTGGCAGCACAGCTAAGAGAATAGAGGAGTTCCTGGCCCAGTTTCAGAGCCTCGA
TGAAACCAAAGAGGAAGAAGATGCTTCTGGGTCACAGCCAAAGGGGCTTCAGAAGACAGACCTCTATCATCTTCAGAAGTCCTTATTGGA
AATGAAGGAGTTAAGAAGAAGTAAGAAGCAAACCAAATTTGAAGTACTCAGAGAAAATGTTGTGAACTTCATTGACTGTCTAGTGAGAGA
ATACCTTCTGCCTCCTGAGACACAGCCTCTCCATGAGGTGGTGTACTTCAGTGCTGCCCATGCCCTTCGTGAGCATTTAAATGCTGCTCC
GCGAATTGCCCTCCATACTGCACTCAACAATCCTTACTATTATCTCAAGAATGAAGCACTGAAAAGCGAAGAAGGCTGCATTCCGAATAT
CGCCCCAGACATCTGCATAGCATACAAACTGCACCTAGAGTGTAGCAGGCTCATCAACCTCGTGGACTGGTCAGAGGCTTTTGCAACAGT
TGTGACAGCTGCTGAAAAAATGGATGCAAATTCTGCAACCTCAGAAGAAATGAATGAAATTATCCATGCTCGGTTTATTAGAGCTGTTTC
TGAACTAGAACTTTTAGGATTTATAAAACCTACCAAACAGAAGACTGACCATGTGGCAAGACTAACATGGGGAGGCTGCTAGAAAGCAAA
TAAGCAAAGCCAGAACTATCACATTTAGCTTAAGAGAAAAAGGTGACCAGTCATATTTACATATATTAGAGGAGCCTGTTTTGTTGAGAA
GATAAATGTGTAACCCCCATTGATGTTTAACCAGAAAAGTACATTGCTAACCCCAAACAGGCATGTATCAAAACACCTGTGGAGTACTTT
AGACTCCAACAAATAATAATGTAACTAAAACTGCTCACACATTTTACTGTACTTTCCAAAGTCATTACTAAATTGTGAGTAAATCATTCT

>101825_101825_6_ZNF292-ORC3_ZNF292_chr6_87865477_ENST00000369577_ORC3_chr6_88344563_ENST00000392844_length(amino acids)=372AA_BP=0
MADEEAEQERLSCGEGGCVAELQRLGERLQELELQLRESRVPAVEAATDYCQQLCQEETQLLLENLHVYHMNYFLVLRCLHKFTSSLPKY
PLGRQIRELYCTCLEKNIWDSEEYASVLQLLRMLAKDELMTILEKCFKVFKSYCENHLGSTAKRIEEFLAQFQSLDETKEEEDASGSQPK
GLQKTDLYHLQKSLLEMKELRRSKKQTKFEVLRENVVNFIDCLVREYLLPPETQPLHEVVYFSAAHALREHLNAAPRIALHTALNNPYYY
LKNEALKSEEGCIPNIAPDICIAYKLHLECSRLINLVDWSEAFATVVTAAEKMDANSATSEEMNEIIHARFIRAVSELELLGFIKPTKQK

--------------------------------------------------------------
>101825_101825_7_ZNF292-ORC3_ZNF292_chr6_87865477_ENST00000369577_ORC3_chr6_88344563_ENST00000417380_length(transcript)=980nt_BP=211nt
ATCACGTGACCCAGGTGCGTACGCGACGGAGCGGGGTGTGAAGATGGCGGACGAAGAGGCCGAGCAGGAGAGGTTGAGTTGCGGCGAAGG
CGGCTGCGTCGCGGAGCTGCAGCGCCTGGGCGAGCGGCTCCAGGAGCTGGAGCTACAGCTGCGGGAGAGCCGGGTACCGGCCGTGGAAGC
GGCCACCGACTACTGTCAGCAGCTGTGCCAGGAGGAAACACAATTATTACTAGAAAACCTGCATGTTTATCATATGAATTACTTCCTGGT
TTTGAGATGTCTTCATAAGTTCACCTCTTCTCTTCCCAAGTATCCACTAGGTCGACAGATCAGAGAGTTGTACTGTACATGTTTAGAAAA
GAACATATGGGATTCAGAGGAGTATGCATCAGTCTTGCAGCTGCTGAGGCTAGGTTTGGCCTTCCTTGATATTCAGTTATTTGGAGCTCA
AAGTGGACAAGAGCTGTTGCTGCCCCTATCCTGGGAAGCTAATCCTTCACATGCTGCTAACTTGGGTTAGATCTTCTGCCAGCAGAACCT
CACCCGTCTTTCCCCTCCAAGCAAGTCAGTGCCGGTGATTCCTTGGACACCAGAAATGCTAATCTTGTCTATTTGAATAGGCCTAAAGGA
TGTTGGCAAAGGATGAACTGATGACCATACTTGAGAAATGTTTCAAGGTTTTTAAGTCTTATTGTGAAAACCACCTTGGCAGCACAGCTA
AGAGAATAGAGGAGTTCCTGGCCCAGTTTCAGAGCCTCGATGCAGAAACCAAAGAGGAAGAAGATGCTTCTGGGTCACAGCCAAAGGGGC
TTCAGAAGACAGACCTCTATCATCTTCAGAAGTCCTTATTGGAAATGAAGGAGTTAAGAAGAAGTAAGAAGCAAACCAAATTTGAAGTAC

>101825_101825_7_ZNF292-ORC3_ZNF292_chr6_87865477_ENST00000369577_ORC3_chr6_88344563_ENST00000417380_length(amino acids)=158AA_BP=0
MADEEAEQERLSCGEGGCVAELQRLGERLQELELQLRESRVPAVEAATDYCQQLCQEETQLLLENLHVYHMNYFLVLRCLHKFTSSLPKY

--------------------------------------------------------------
>101825_101825_8_ZNF292-ORC3_ZNF292_chr6_87865477_ENST00000369577_ORC3_chr6_88344563_ENST00000546266_length(transcript)=1204nt_BP=211nt
ATCACGTGACCCAGGTGCGTACGCGACGGAGCGGGGTGTGAAGATGGCGGACGAAGAGGCCGAGCAGGAGAGGTTGAGTTGCGGCGAAGG
CGGCTGCGTCGCGGAGCTGCAGCGCCTGGGCGAGCGGCTCCAGGAGCTGGAGCTACAGCTGCGGGAGAGCCGGGTACCGGCCGTGGAAGC
GGCCACCGACTACTGTCAGCAGCTGTGCCAGGAGGAAACACAATTATTACTAGAAAACCTGCATGTTTATCATATGAATTACTTCCTGGT
TTTGAGATGTCTTCATAAGTTCACCTCTTCTCTTCCCAAGTATCCACTAGGTCGACAGATCAGAGAGTTGTACTGTACATGTTTAGAAAA
GAACATATGGGATTCAGAGGAGTATGCATCAGTCTTGCAGCTGCTGAGGATGTTGGCAAAGGATGAACTGATGACCATACTTGAGAAATG
TTTCAAGGTTTTTAAGTCTTATTGTGAAAACCACCTTGGCAGCACAGCTAAGAGAATAGAGGAGTTCCTGGCCCAGTTTCAGAGCCTCGA
TGAAACCAAAGAGGAAGAAGATGCTTCTGGGTCACAGCCAAAGGGGCTTCAGAAGACAGACCTCTATCATCTTCAGAAGTCCTTATTGGA
AATGAAGGAGTTAAGAAGAAGTAAGAAGCAAACCAAATTTGAAGTACTCAGAGAAAATGTTGTGAACTTCATTGACTGTCTAGTGAGAGA
ATACCTTCTGCCTCCTGAGACACAGCCTCTCCATGAGGTGGTGTACTTCAGTGCTGCCCATGCCCTTCGTGAGCATTTAAATGCTGCTCC
GCGAATTGCCCTCCATACTGCACTCAACAATCCTTACTATTATCTCAAGAATGAAGCACTGAAAAGCGAAGAAGGCTGCATTCCGAATAT
CGCCCCAGACATCTGCATAGCATACAAACTGCACCTAGAGTGTAGCAGGCTCATCAACCTCGTGGACTGGTCAGAGGCTTTTGCAACAGT
TGTGACAGCTGCTGAAAAAATGGATGCAAATTCTGCAACCTCAGAAGAAATGAATGAAATTATCCATGCTCGGTTTATTAGAGCTGTTTC
TGAACTAGAACTTTTAGGATTTATAAAACCTACCAAACAGAAGACTGACCATGTGGCAAGACTAACATGGGGAGGCTGCTAGAAAGCAAA

>101825_101825_8_ZNF292-ORC3_ZNF292_chr6_87865477_ENST00000369577_ORC3_chr6_88344563_ENST00000546266_length(amino acids)=372AA_BP=0
MADEEAEQERLSCGEGGCVAELQRLGERLQELELQLRESRVPAVEAATDYCQQLCQEETQLLLENLHVYHMNYFLVLRCLHKFTSSLPKY
PLGRQIRELYCTCLEKNIWDSEEYASVLQLLRMLAKDELMTILEKCFKVFKSYCENHLGSTAKRIEEFLAQFQSLDETKEEEDASGSQPK
GLQKTDLYHLQKSLLEMKELRRSKKQTKFEVLRENVVNFIDCLVREYLLPPETQPLHEVVYFSAAHALREHLNAAPRIALHTALNNPYYY
LKNEALKSEEGCIPNIAPDICIAYKLHLECSRLINLVDWSEAFATVVTAAEKMDANSATSEEMNEIIHARFIRAVSELELLGFIKPTKQK

--------------------------------------------------------------
>101825_101825_9_ZNF292-ORC3_ZNF292_chr6_87865477_ENST00000392985_ORC3_chr6_88344563_ENST00000257789_length(transcript)=1687nt_BP=405nt
ATGGAACAGGTCTTCGAATCTCCCCAGGAACATCTCAGAGGATATGTCCGTAGAAGACTTCGTGGACTGGGGAAAGCCACGCCGGGATCG
GGACGCCGGAGAGGGTCGCCCCTCCCTAGGCTTTTTCCCGTCGCGGCGCCCACGTGACCGAGAGCAGGCCTTCACCAGCCCGCCCCTTTC
GGCCGCTGCTGCCCACTTCCCGCTCGGGGTGCGTACGCGACGGAGCGGGGTGTGAAGATGGCGGACGAAGAGGCCGAGCAGGAGAGGTTG
AGTTGCGGCGAAGGCGGCTGCGTCGCGGAGCTGCAGCGCCTGGGCGAGCGGCTCCAGGAGCTGGAGCTACAGCTGCGGGAGAGCCGGGTA
CCGGCCGTGGAAGCGGCCACCGACTACTGTCAGCAGCTGTGCCAGGAGGAAACACAATTATTACTAGAAAACCTGCATGTTTATCATATG
AATTACTTCCTGGTTTTGAGATGTCTTCATAAGTTCACCTCTTCTCTTCCCAAGTATCCACTAGGTCGACAGATCAGAGAGTTGTACTGT
ACATGTTTAGAAAAGAACATATGGGATTCAGAGGAGTATGCATCAGTCTTGCAGCTGCTGAGGATGTTGGCAAAGGATGAACTGATGACC
ATACTTGAGAAATGTTTCAAGGTTTTTAAGTCTTATTGTGAAAACCACCTTGGCAGCACAGCTAAGAGAATAGAGGAGTTCCTGGCCCAG
TTTCAGAGCCTCGATGCAGAAACCAAAGAGGAAGAAGATGCTTCTGGGTCACAGCCAAAGGGGCTTCAGAAGACAGACCTCTATCATCTT
CAGAAGTCCTTATTGGAAATGAAGGAGTTAAGAAGAAGTAAGAAGCAAACCAAATTTGAAGTACTCAGAGAAAATGTTGTGAACTTCATT
GACTGTCTAGTGAGAGAATACCTTCTGCCTCCTGAGACACAGCCTCTCCATGAGGTGGTGTACTTCAGTGCTGCCCATGCCCTTCGTGAG
CATTTAAATGCTGCTCCGCGAATTGCCCTCCATACTGCACTCAACAATCCTTACTATTATCTCAAGAATGAAGCACTGAAAAGCGAAGAA
GGCTGCATTCCGAATATCGCCCCAGACATCTGCATAGCATACAAACTGCACCTAGAGTGTAGCAGGCTCATCAACCTCGTGGACTGGTCA
GAGGCTTTTGCAACAGTTGTGACAGCTGCTGAAAAAATGGATGCAAATTCTGCAACCTCAGAAGAAATGAATGAAATTATCCATGCTCGG
TTTATTAGAGCTGTTTCTGAACTAGAACTTTTAGGATTTATAAAACCTACCAAACAGAAGACTGACCATGTGGCAAGACTAACATGGGGA
GGCTGCTAGAAAGCAAATAAGCAAAGCCAGAACTATCACATTTAGCTTAAGAGAAAAAGGTGACCAGTCATATTTACATATATTAGAGGA
GCCTGTTTTGTTGAGAAGATAAATGTGTAACCCCCATTGATGTTTAACCAGAAAAGTACATTGCTAACCCCAAACAGGCATGTATCAAAA
CACCTGTGGAGTACTTTAGACTCCAACAAATAATAATGTAACTAAAACTGCTCACACATTTTACTGTACTTTCCAAAGTCATTACTAAAT

>101825_101825_9_ZNF292-ORC3_ZNF292_chr6_87865477_ENST00000392985_ORC3_chr6_88344563_ENST00000257789_length(amino acids)=373AA_BP=0
MADEEAEQERLSCGEGGCVAELQRLGERLQELELQLRESRVPAVEAATDYCQQLCQEETQLLLENLHVYHMNYFLVLRCLHKFTSSLPKY
PLGRQIRELYCTCLEKNIWDSEEYASVLQLLRMLAKDELMTILEKCFKVFKSYCENHLGSTAKRIEEFLAQFQSLDAETKEEEDASGSQP
KGLQKTDLYHLQKSLLEMKELRRSKKQTKFEVLRENVVNFIDCLVREYLLPPETQPLHEVVYFSAAHALREHLNAAPRIALHTALNNPYY
YLKNEALKSEEGCIPNIAPDICIAYKLHLECSRLINLVDWSEAFATVVTAAEKMDANSATSEEMNEIIHARFIRAVSELELLGFIKPTKQ

--------------------------------------------------------------
>101825_101825_10_ZNF292-ORC3_ZNF292_chr6_87865477_ENST00000392985_ORC3_chr6_88344563_ENST00000392844_length(transcript)=1684nt_BP=405nt
ATGGAACAGGTCTTCGAATCTCCCCAGGAACATCTCAGAGGATATGTCCGTAGAAGACTTCGTGGACTGGGGAAAGCCACGCCGGGATCG
GGACGCCGGAGAGGGTCGCCCCTCCCTAGGCTTTTTCCCGTCGCGGCGCCCACGTGACCGAGAGCAGGCCTTCACCAGCCCGCCCCTTTC
GGCCGCTGCTGCCCACTTCCCGCTCGGGGTGCGTACGCGACGGAGCGGGGTGTGAAGATGGCGGACGAAGAGGCCGAGCAGGAGAGGTTG
AGTTGCGGCGAAGGCGGCTGCGTCGCGGAGCTGCAGCGCCTGGGCGAGCGGCTCCAGGAGCTGGAGCTACAGCTGCGGGAGAGCCGGGTA
CCGGCCGTGGAAGCGGCCACCGACTACTGTCAGCAGCTGTGCCAGGAGGAAACACAATTATTACTAGAAAACCTGCATGTTTATCATATG
AATTACTTCCTGGTTTTGAGATGTCTTCATAAGTTCACCTCTTCTCTTCCCAAGTATCCACTAGGTCGACAGATCAGAGAGTTGTACTGT
ACATGTTTAGAAAAGAACATATGGGATTCAGAGGAGTATGCATCAGTCTTGCAGCTGCTGAGGATGTTGGCAAAGGATGAACTGATGACC
ATACTTGAGAAATGTTTCAAGGTTTTTAAGTCTTATTGTGAAAACCACCTTGGCAGCACAGCTAAGAGAATAGAGGAGTTCCTGGCCCAG
TTTCAGAGCCTCGATGAAACCAAAGAGGAAGAAGATGCTTCTGGGTCACAGCCAAAGGGGCTTCAGAAGACAGACCTCTATCATCTTCAG
AAGTCCTTATTGGAAATGAAGGAGTTAAGAAGAAGTAAGAAGCAAACCAAATTTGAAGTACTCAGAGAAAATGTTGTGAACTTCATTGAC
TGTCTAGTGAGAGAATACCTTCTGCCTCCTGAGACACAGCCTCTCCATGAGGTGGTGTACTTCAGTGCTGCCCATGCCCTTCGTGAGCAT
TTAAATGCTGCTCCGCGAATTGCCCTCCATACTGCACTCAACAATCCTTACTATTATCTCAAGAATGAAGCACTGAAAAGCGAAGAAGGC
TGCATTCCGAATATCGCCCCAGACATCTGCATAGCATACAAACTGCACCTAGAGTGTAGCAGGCTCATCAACCTCGTGGACTGGTCAGAG
GCTTTTGCAACAGTTGTGACAGCTGCTGAAAAAATGGATGCAAATTCTGCAACCTCAGAAGAAATGAATGAAATTATCCATGCTCGGTTT
ATTAGAGCTGTTTCTGAACTAGAACTTTTAGGATTTATAAAACCTACCAAACAGAAGACTGACCATGTGGCAAGACTAACATGGGGAGGC
TGCTAGAAAGCAAATAAGCAAAGCCAGAACTATCACATTTAGCTTAAGAGAAAAAGGTGACCAGTCATATTTACATATATTAGAGGAGCC
TGTTTTGTTGAGAAGATAAATGTGTAACCCCCATTGATGTTTAACCAGAAAAGTACATTGCTAACCCCAAACAGGCATGTATCAAAACAC
CTGTGGAGTACTTTAGACTCCAACAAATAATAATGTAACTAAAACTGCTCACACATTTTACTGTACTTTCCAAAGTCATTACTAAATTGT

>101825_101825_10_ZNF292-ORC3_ZNF292_chr6_87865477_ENST00000392985_ORC3_chr6_88344563_ENST00000392844_length(amino acids)=372AA_BP=0
MADEEAEQERLSCGEGGCVAELQRLGERLQELELQLRESRVPAVEAATDYCQQLCQEETQLLLENLHVYHMNYFLVLRCLHKFTSSLPKY
PLGRQIRELYCTCLEKNIWDSEEYASVLQLLRMLAKDELMTILEKCFKVFKSYCENHLGSTAKRIEEFLAQFQSLDETKEEEDASGSQPK
GLQKTDLYHLQKSLLEMKELRRSKKQTKFEVLRENVVNFIDCLVREYLLPPETQPLHEVVYFSAAHALREHLNAAPRIALHTALNNPYYY
LKNEALKSEEGCIPNIAPDICIAYKLHLECSRLINLVDWSEAFATVVTAAEKMDANSATSEEMNEIIHARFIRAVSELELLGFIKPTKQK

--------------------------------------------------------------
>101825_101825_11_ZNF292-ORC3_ZNF292_chr6_87865477_ENST00000392985_ORC3_chr6_88344563_ENST00000417380_length(transcript)=1174nt_BP=405nt
ATGGAACAGGTCTTCGAATCTCCCCAGGAACATCTCAGAGGATATGTCCGTAGAAGACTTCGTGGACTGGGGAAAGCCACGCCGGGATCG
GGACGCCGGAGAGGGTCGCCCCTCCCTAGGCTTTTTCCCGTCGCGGCGCCCACGTGACCGAGAGCAGGCCTTCACCAGCCCGCCCCTTTC
GGCCGCTGCTGCCCACTTCCCGCTCGGGGTGCGTACGCGACGGAGCGGGGTGTGAAGATGGCGGACGAAGAGGCCGAGCAGGAGAGGTTG
AGTTGCGGCGAAGGCGGCTGCGTCGCGGAGCTGCAGCGCCTGGGCGAGCGGCTCCAGGAGCTGGAGCTACAGCTGCGGGAGAGCCGGGTA
CCGGCCGTGGAAGCGGCCACCGACTACTGTCAGCAGCTGTGCCAGGAGGAAACACAATTATTACTAGAAAACCTGCATGTTTATCATATG
AATTACTTCCTGGTTTTGAGATGTCTTCATAAGTTCACCTCTTCTCTTCCCAAGTATCCACTAGGTCGACAGATCAGAGAGTTGTACTGT
ACATGTTTAGAAAAGAACATATGGGATTCAGAGGAGTATGCATCAGTCTTGCAGCTGCTGAGGCTAGGTTTGGCCTTCCTTGATATTCAG
TTATTTGGAGCTCAAAGTGGACAAGAGCTGTTGCTGCCCCTATCCTGGGAAGCTAATCCTTCACATGCTGCTAACTTGGGTTAGATCTTC
TGCCAGCAGAACCTCACCCGTCTTTCCCCTCCAAGCAAGTCAGTGCCGGTGATTCCTTGGACACCAGAAATGCTAATCTTGTCTATTTGA
ATAGGCCTAAAGGATGTTGGCAAAGGATGAACTGATGACCATACTTGAGAAATGTTTCAAGGTTTTTAAGTCTTATTGTGAAAACCACCT
TGGCAGCACAGCTAAGAGAATAGAGGAGTTCCTGGCCCAGTTTCAGAGCCTCGATGCAGAAACCAAAGAGGAAGAAGATGCTTCTGGGTC
ACAGCCAAAGGGGCTTCAGAAGACAGACCTCTATCATCTTCAGAAGTCCTTATTGGAAATGAAGGAGTTAAGAAGAAGTAAGAAGCAAAC
CAAATTTGAAGTACTCAGAGAAAATGTTGTGAACTTCATTGACTGTCTAGTGAGAGAATACCTTCTGCCTCCTGAGACACAGCCTCTCCA

>101825_101825_11_ZNF292-ORC3_ZNF292_chr6_87865477_ENST00000392985_ORC3_chr6_88344563_ENST00000417380_length(amino acids)=158AA_BP=0
MADEEAEQERLSCGEGGCVAELQRLGERLQELELQLRESRVPAVEAATDYCQQLCQEETQLLLENLHVYHMNYFLVLRCLHKFTSSLPKY

--------------------------------------------------------------
>101825_101825_12_ZNF292-ORC3_ZNF292_chr6_87865477_ENST00000392985_ORC3_chr6_88344563_ENST00000546266_length(transcript)=1398nt_BP=405nt
ATGGAACAGGTCTTCGAATCTCCCCAGGAACATCTCAGAGGATATGTCCGTAGAAGACTTCGTGGACTGGGGAAAGCCACGCCGGGATCG
GGACGCCGGAGAGGGTCGCCCCTCCCTAGGCTTTTTCCCGTCGCGGCGCCCACGTGACCGAGAGCAGGCCTTCACCAGCCCGCCCCTTTC
GGCCGCTGCTGCCCACTTCCCGCTCGGGGTGCGTACGCGACGGAGCGGGGTGTGAAGATGGCGGACGAAGAGGCCGAGCAGGAGAGGTTG
AGTTGCGGCGAAGGCGGCTGCGTCGCGGAGCTGCAGCGCCTGGGCGAGCGGCTCCAGGAGCTGGAGCTACAGCTGCGGGAGAGCCGGGTA
CCGGCCGTGGAAGCGGCCACCGACTACTGTCAGCAGCTGTGCCAGGAGGAAACACAATTATTACTAGAAAACCTGCATGTTTATCATATG
AATTACTTCCTGGTTTTGAGATGTCTTCATAAGTTCACCTCTTCTCTTCCCAAGTATCCACTAGGTCGACAGATCAGAGAGTTGTACTGT
ACATGTTTAGAAAAGAACATATGGGATTCAGAGGAGTATGCATCAGTCTTGCAGCTGCTGAGGATGTTGGCAAAGGATGAACTGATGACC
ATACTTGAGAAATGTTTCAAGGTTTTTAAGTCTTATTGTGAAAACCACCTTGGCAGCACAGCTAAGAGAATAGAGGAGTTCCTGGCCCAG
TTTCAGAGCCTCGATGAAACCAAAGAGGAAGAAGATGCTTCTGGGTCACAGCCAAAGGGGCTTCAGAAGACAGACCTCTATCATCTTCAG
AAGTCCTTATTGGAAATGAAGGAGTTAAGAAGAAGTAAGAAGCAAACCAAATTTGAAGTACTCAGAGAAAATGTTGTGAACTTCATTGAC
TGTCTAGTGAGAGAATACCTTCTGCCTCCTGAGACACAGCCTCTCCATGAGGTGGTGTACTTCAGTGCTGCCCATGCCCTTCGTGAGCAT
TTAAATGCTGCTCCGCGAATTGCCCTCCATACTGCACTCAACAATCCTTACTATTATCTCAAGAATGAAGCACTGAAAAGCGAAGAAGGC
TGCATTCCGAATATCGCCCCAGACATCTGCATAGCATACAAACTGCACCTAGAGTGTAGCAGGCTCATCAACCTCGTGGACTGGTCAGAG
GCTTTTGCAACAGTTGTGACAGCTGCTGAAAAAATGGATGCAAATTCTGCAACCTCAGAAGAAATGAATGAAATTATCCATGCTCGGTTT
ATTAGAGCTGTTTCTGAACTAGAACTTTTAGGATTTATAAAACCTACCAAACAGAAGACTGACCATGTGGCAAGACTAACATGGGGAGGC

>101825_101825_12_ZNF292-ORC3_ZNF292_chr6_87865477_ENST00000392985_ORC3_chr6_88344563_ENST00000546266_length(amino acids)=372AA_BP=0
MADEEAEQERLSCGEGGCVAELQRLGERLQELELQLRESRVPAVEAATDYCQQLCQEETQLLLENLHVYHMNYFLVLRCLHKFTSSLPKY
PLGRQIRELYCTCLEKNIWDSEEYASVLQLLRMLAKDELMTILEKCFKVFKSYCENHLGSTAKRIEEFLAQFQSLDETKEEEDASGSQPK
GLQKTDLYHLQKSLLEMKELRRSKKQTKFEVLRENVVNFIDCLVREYLLPPETQPLHEVVYFSAAHALREHLNAAPRIALHTALNNPYYY
LKNEALKSEEGCIPNIAPDICIAYKLHLECSRLINLVDWSEAFATVVTAAEKMDANSATSEEMNEIIHARFIRAVSELELLGFIKPTKQK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZNF292-ORC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF292-ORC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF292-ORC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource