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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF302-ANKRD27 (FusionGDB2 ID:101838)

Fusion Gene Summary for ZNF302-ANKRD27

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF302-ANKRD27
Fusion gene ID: 101838
HgeneTgene
Gene symbol

ZNF302

ANKRD27

Gene ID

55900

84079

Gene namezinc finger protein 302ankyrin repeat domain 27
SynonymsHSD16|MST154|MSTP154|ZNF135L|ZNF140L|ZNF327PP12899|VARP
Cytomap

19q13.11

19q13.11

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 302zinc finger protein 327ankyrin repeat domain-containing protein 27VPS9 domain-containing proteinVPS9-ankyrin-repeat proteinVps9 domain and ankyrin-repeat-containing proteinankyrin repeat domain 27 (VPS9 domain)
Modification date2020031320200313
UniProtAcc.

Q96NW4

Ensembl transtripts involved in fusion geneENST00000423823, ENST00000446502, 
ENST00000457781, ENST00000505242, 
ENST00000505365, ENST00000507959, 
ENST00000509528, 		ENST00000587352, 
ENST00000306065, 
Fusion gene scores* DoF score4 X 3 X 4=485 X 7 X 3=105
# samples 47
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/105*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF302 [Title/Abstract] AND ANKRD27 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF302(35169718)-ANKRD27(33098738), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneANKRD27

GO:0035544

negative regulation of SNARE complex assembly

24856514

TgeneANKRD27

GO:0045022

early endosome to late endosome transport

16525121


check buttonFusion gene breakpoints across ZNF302 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ANKRD27 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-D1-A3JP-01AZNF302chr19

35169718

-ANKRD27chr19

33098738

-


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Fusion Gene ORF analysis for ZNF302-ANKRD27

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000423823ENST00000587352ZNF302chr19

35169718

-ANKRD27chr19

33098738

-
5CDS-intronENST00000446502ENST00000587352ZNF302chr19

35169718

-ANKRD27chr19

33098738

-
5CDS-intronENST00000457781ENST00000587352ZNF302chr19

35169718

-ANKRD27chr19

33098738

-
5CDS-intronENST00000505242ENST00000587352ZNF302chr19

35169718

-ANKRD27chr19

33098738

-
5CDS-intronENST00000505365ENST00000587352ZNF302chr19

35169718

-ANKRD27chr19

33098738

-
5CDS-intronENST00000507959ENST00000587352ZNF302chr19

35169718

-ANKRD27chr19

33098738

-
5CDS-intronENST00000509528ENST00000587352ZNF302chr19

35169718

-ANKRD27chr19

33098738

-
In-frameENST00000423823ENST00000306065ZNF302chr19

35169718

-ANKRD27chr19

33098738

-
In-frameENST00000446502ENST00000306065ZNF302chr19

35169718

-ANKRD27chr19

33098738

-
In-frameENST00000457781ENST00000306065ZNF302chr19

35169718

-ANKRD27chr19

33098738

-
In-frameENST00000505242ENST00000306065ZNF302chr19

35169718

-ANKRD27chr19

33098738

-
In-frameENST00000505365ENST00000306065ZNF302chr19

35169718

-ANKRD27chr19

33098738

-
In-frameENST00000507959ENST00000306065ZNF302chr19

35169718

-ANKRD27chr19

33098738

-
In-frameENST00000509528ENST00000306065ZNF302chr19

35169718

-ANKRD27chr19

33098738

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000509528ZNF302chr1935169718-ENST00000306065ANKRD27chr1933098738-24032872511264337
ENST00000457781ZNF302chr1935169718-ENST00000306065ANKRD27chr1933098738-23652492131226337
ENST00000505242ZNF302chr1935169718-ENST00000306065ANKRD27chr1933098738-26195034671480337
ENST00000423823ZNF302chr1935169718-ENST00000306065ANKRD27chr1933098738-23612452091222337
ENST00000507959ZNF302chr1935169718-ENST00000306065ANKRD27chr1933098738-23482321961209337
ENST00000446502ZNF302chr1935169718-ENST00000306065ANKRD27chr1933098738-23332171811194337
ENST00000505365ZNF302chr1935169718-ENST00000306065ANKRD27chr1933098738-24613453091322337

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000509528ENST00000306065ZNF302chr1935169718-ANKRD27chr1933098738-0.0056770070.994323
ENST00000457781ENST00000306065ZNF302chr1935169718-ANKRD27chr1933098738-0.005924660.9940753
ENST00000505242ENST00000306065ZNF302chr1935169718-ANKRD27chr1933098738-0.0058464260.99415356
ENST00000423823ENST00000306065ZNF302chr1935169718-ANKRD27chr1933098738-0.0061714980.9938285
ENST00000507959ENST00000306065ZNF302chr1935169718-ANKRD27chr1933098738-0.0058276240.9941724
ENST00000446502ENST00000306065ZNF302chr1935169718-ANKRD27chr1933098738-0.0057066620.99429333
ENST00000505365ENST00000306065ZNF302chr1935169718-ANKRD27chr1933098738-0.0058870540.9941129

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Fusion Genomic Features for ZNF302-ANKRD27


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF302-ANKRD27


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:35169718/chr19:33098738)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ANKRD27

Q96NW4

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics (PubMed:16525121, PubMed:18477474). May regulate the participation of VAMP7 in membrane fusion events; in vitro inhibits VAMP7-mediated SNARE complex formation by trapping VAMP7 in a closed, fusogenically inactive conformation (PubMed:23104059). Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with Rab32, Rab38 and VAMP7 (By similarity). Involved in the regulation of neurite growth; the function seems to require its GEF activity, probably towards Rab21, and VAMP7 but not Rab32/38 (By similarity). Proposed to be involved in Golgi sorting of VAMP7 and transport of VAMP7 vesicles to the cell surface; the function seems to implicate kinesin heavy chain isoform 5 proteins, GOLGA4, RAB21 and MACF1 (PubMed:22705394). Required for the colocalization of VAMP7 and Rab21, probably on TGN sites (PubMed:19745841). Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with VPS29 (PubMed:24856514). Regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity). {ECO:0000250|UniProtKB:Q3UMR0, ECO:0000269|PubMed:23104059, ECO:0000269|PubMed:24856514, ECO:0000305|PubMed:16525121, ECO:0000305|PubMed:18477474, ECO:0000305|PubMed:22705394}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneANKRD27chr19:35169718chr19:33098738ENST000003060652129743_7727251051.0RepeatNote=ANK 8
TgeneANKRD27chr19:35169718chr19:33098738ENST000003060652129776_8057251051.0RepeatNote=ANK 9
TgeneANKRD27chr19:35169718chr19:33098738ENST000003060652129809_8387251051.0RepeatNote=ANK 10
TgeneANKRD27chr19:35169718chr19:33098738ENST000003060652129842_8717251051.0RepeatNote=ANK 11

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF302chr19:35169718chr19:33098738ENST00000423823-254_753400.0DomainKRAB
HgeneZNF302chr19:35169718chr19:33098738ENST00000457781-254_753400.0DomainKRAB
HgeneZNF302chr19:35169718chr19:33098738ENST00000505242-254_753400.0DomainKRAB
HgeneZNF302chr19:35169718chr19:33098738ENST00000423823-25280_3023400.0Zinc fingerC2H2-type 1
HgeneZNF302chr19:35169718chr19:33098738ENST00000423823-25308_3303400.0Zinc fingerC2H2-type 2
HgeneZNF302chr19:35169718chr19:33098738ENST00000423823-25336_3583400.0Zinc fingerC2H2-type 3
HgeneZNF302chr19:35169718chr19:33098738ENST00000423823-25364_3863400.0Zinc fingerC2H2-type 4
HgeneZNF302chr19:35169718chr19:33098738ENST00000423823-25392_4143400.0Zinc fingerC2H2-type 5
HgeneZNF302chr19:35169718chr19:33098738ENST00000423823-25420_4423400.0Zinc fingerC2H2-type 6
HgeneZNF302chr19:35169718chr19:33098738ENST00000423823-25448_4703400.0Zinc fingerC2H2-type 7
HgeneZNF302chr19:35169718chr19:33098738ENST00000457781-25280_3023400.0Zinc fingerC2H2-type 1
HgeneZNF302chr19:35169718chr19:33098738ENST00000457781-25308_3303400.0Zinc fingerC2H2-type 2
HgeneZNF302chr19:35169718chr19:33098738ENST00000457781-25336_3583400.0Zinc fingerC2H2-type 3
HgeneZNF302chr19:35169718chr19:33098738ENST00000457781-25364_3863400.0Zinc fingerC2H2-type 4
HgeneZNF302chr19:35169718chr19:33098738ENST00000457781-25392_4143400.0Zinc fingerC2H2-type 5
HgeneZNF302chr19:35169718chr19:33098738ENST00000457781-25420_4423400.0Zinc fingerC2H2-type 6
HgeneZNF302chr19:35169718chr19:33098738ENST00000457781-25448_4703400.0Zinc fingerC2H2-type 7
HgeneZNF302chr19:35169718chr19:33098738ENST00000505242-25280_3023400.0Zinc fingerC2H2-type 1
HgeneZNF302chr19:35169718chr19:33098738ENST00000505242-25308_3303400.0Zinc fingerC2H2-type 2
HgeneZNF302chr19:35169718chr19:33098738ENST00000505242-25336_3583400.0Zinc fingerC2H2-type 3
HgeneZNF302chr19:35169718chr19:33098738ENST00000505242-25364_3863400.0Zinc fingerC2H2-type 4
HgeneZNF302chr19:35169718chr19:33098738ENST00000505242-25392_4143400.0Zinc fingerC2H2-type 5
HgeneZNF302chr19:35169718chr19:33098738ENST00000505242-25420_4423400.0Zinc fingerC2H2-type 6
HgeneZNF302chr19:35169718chr19:33098738ENST00000505242-25448_4703400.0Zinc fingerC2H2-type 7
TgeneANKRD27chr19:35169718chr19:33098738ENST000003060652129233_3717251051.0DomainVPS9
TgeneANKRD27chr19:35169718chr19:33098738ENST0000030606521291_3727251051.0RegionSufficient for GEF activity towards RAB21
TgeneANKRD27chr19:35169718chr19:33098738ENST000003060652129396_4267251051.0RepeatNote=ANK 1
TgeneANKRD27chr19:35169718chr19:33098738ENST000003060652129462_4917251051.0RepeatNote=ANK 2
TgeneANKRD27chr19:35169718chr19:33098738ENST000003060652129495_5247251051.0RepeatNote=ANK 3
TgeneANKRD27chr19:35169718chr19:33098738ENST000003060652129528_5607251051.0RepeatNote=ANK 4
TgeneANKRD27chr19:35169718chr19:33098738ENST000003060652129564_5937251051.0RepeatNote=ANK 5
TgeneANKRD27chr19:35169718chr19:33098738ENST000003060652129597_6277251051.0RepeatNote=ANK 6
TgeneANKRD27chr19:35169718chr19:33098738ENST000003060652129668_6987251051.0RepeatNote=ANK 7


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Fusion Gene Sequence for ZNF302-ANKRD27


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>101838_101838_1_ZNF302-ANKRD27_ZNF302_chr19_35169718_ENST00000423823_ANKRD27_chr19_33098738_ENST00000306065_length(transcript)=2361nt_BP=245nt
GATAGCTTCAGGCCTGGCGGCGGCTTCCAAGCTAAGGAACGGTTTGGGGCAGTGTCGTTCCCGGAGGTCGGCCGCCGTTACCCGCTCACC
AGCTACGCGGCGCGTCAGGTCCGCGGAGGCGCGGGCTCGGGGCGCCTGCGGGACGGTGAGGCCCTGCTGAGGACTCCGGACACTGCCCAT
CTCTAAGATAAGAACCTGGAAAGGGGACTCTGTTGGCCATTGGAAATTGCAGAATAATGTCTCAGAGGCTGGCGAAGGTTCCTGCCAGTG
GGCTTGGTGTGAACGTGACCAGCCAGGACGGCTCCTCCCCGCTGCATGTCGCCGCCCTGCACGGCCGGGCGGACCTCATCCCCCTCCTGC
TGAAGCACGGGGCCAACGCAGGTGCCAGGAACGCAGACCAAGCCGTCCCGCTCCACCTGGCCTGCCAGCAGGGCCACTTTCAGGTGGTGA
AGTGTCTGTTAGATTCGAATGCAAAACCCAATAAGAAGGACCTCAGTGGAAACACGCCCCTCATTTACGCCTGCTCCGGTGGCCATCACG
AGCTTGTGGCACTGCTGCTACAGCACGGGGCCTCCATTAACGCTTCTAACAATAAGGGCAACACAGCGCTGCACGAGGCTGTGATTGAAA
AGCACGTCTTCGTGGTAGAGCTGCTTCTGCTCCACGGAGCGTCAGTTCAGGTGCTGAACAAGCGGCAGCGCACGGCTGTAGACTGTGCTG
AACAGAATTCAAAAATAATGGAATTGCTTCAGGTGGTACCAAGCTGTGTTGCTTCATTAGATGATGTGGCTGAAACTGACCGCAAGGAGT
ATGTCACTGTTAAGATCAGGAAAAAATGGAACTCAAAACTGTATGATCTACCAGATGAGCCTTTTACAAGACAGTTTTACTTTGTCCACT
CAGCTGGTCAGTTTAAGGGAAAGACTTCAAGGGAGATTATGGCAAGAGATAGAAGTGTCCCTAATTTAACCGAAGGTTCTTTGCATGAGC
CAGGGAGGCAAAGTGTCACACTGAGACAGAATAACCTGCCAGCTCAGAGTGGATCTCATGCTGCTGAGAAAGGCAACAGCGACTGGCCAG
AGAGGCCTGGACTGACACAGACTGGCCCTGGACACAGACGGATGCTGCGGAGACACACGGTAGAGGATGCGGTCGTGTCCCAGGGCCCGG
AGGCTGCTGGCCCCCTCTCCACTCCCCAAGAGGTTAGTGCTTCCCGGTCCTAACAGGAATGAGGAGTTGTTGAACCCACTGCTAGGAAGC
AAGGATGCAACAAGATGATGCTGAGCGTGAACACATCTGAGAACTAAATGTGCTTCCATGAGACTGGCTTGAGAAGTCTTCAGCACCAAG
TTCCTGAAAGCTTTTCTGTGGCAGGAAAGAATGCAACAAAAAAGTTAACCACCACCATCTCTCTCCTCTTCAAAGCTAATGAATACAATT
GAAACAGACAAAAATTCCAGTAGCATCCAGATCCTTAAGCCAGAGGTGCATGCTTCTTTTTAAGTATGAGGGTTTGTTGGTCACAGTGGG
AGAGGTTTCACCACCGCATTCTGACCTCCTCCTCCCAAAAGGTGCTAAACCTCTCTGACCTGTGTACATTCACAAACCACAGCTAGAATT
CCTCCACCTAGGATTAAGCTGGAGAGAAGTAAGTAATTTAGGTTTCATGGTACTGTAGAGGCCAGGCTGAAATGTCATATCTGAAGGAAG
AAAGCAGCAGCTGGACAATGTTTCTTTGCAAAGCAACACTCGAACCAAAAGATGCCTCAATCCCATTTTGATATTCATTTTAGTGAAAGG
ATGCATCAGACCTGTTCCACATCATGCACATGGGAAAGGGTGGTTATCATTTTCCTTCTAACAAGTAGGTACAGATATTCGGTTACTACA
CGTGCACCTGTAGCAGTATTTCTAGAAACATCCCTTTTTGTTGAGAACCTCCCTTGAATGTCTGTCACACTCACACCTGACGGGATGGTT
ACTGGATTAGAGAGTAGATTTGGCACATCTTTTCTTAGTCTTTTGATTCAAATTCAAAACTTAACAGCACAAACCAGGTCAGAGTTACTT
TCGGTTAGAATTTATTGCCATTTATTCCTTTTTATAAATTTCTATAGATTATACTGTTATTTTTATGTTATTGGCCTAGAGCTACACGTA
TATGGGTTTGTCCTGAGTCCGTTTTCAAATGACCTTGTGATAGGGAAATGGTTTTGTCCATGTTCTTGGAAATACTTGTGTATGTACAGA
AGGAAGGGAGGGATTATTTTTCTACAAAGTAATTTATGATTTCTAATTTTCTAATGTGCCTTGGATATGTGCCAAATGATGGAAAAGAAA

>101838_101838_1_ZNF302-ANKRD27_ZNF302_chr19_35169718_ENST00000423823_ANKRD27_chr19_33098738_ENST00000306065_length(amino acids)=337AA_BP=10
MLAIGNCRIMSQRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKP
NKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELL
QVVPSCVASLDDVAETDRKEYVTVKIRKKWNSKLYDLPDEPFTRQFYFVHSAGQFKGKTSREIMARDRSVPNLTEGSLHEPGRQSVTLRQ

--------------------------------------------------------------
>101838_101838_2_ZNF302-ANKRD27_ZNF302_chr19_35169718_ENST00000446502_ANKRD27_chr19_33098738_ENST00000306065_length(transcript)=2333nt_BP=217nt
AAGCTAAGGAACGGTTTGGGGCAGTGTCGTTCCCGGAGGTCGGCCGCCGTTACCCGCTCACCAGCTACGCGGCGCGTCAGGTCCGCGGAG
GCGCGGGCTCGGGGCGCCTGCGGGACGGTGAGGCCCTGCTGAGGACTCCGGACACTGCCCATCTCTAAGATAAGAACCTGGAAAGGGGAC
TCTGTTGGCCATTGGAAATTGCAGAATAATGTCTCAGAGGCTGGCGAAGGTTCCTGCCAGTGGGCTTGGTGTGAACGTGACCAGCCAGGA
CGGCTCCTCCCCGCTGCATGTCGCCGCCCTGCACGGCCGGGCGGACCTCATCCCCCTCCTGCTGAAGCACGGGGCCAACGCAGGTGCCAG
GAACGCAGACCAAGCCGTCCCGCTCCACCTGGCCTGCCAGCAGGGCCACTTTCAGGTGGTGAAGTGTCTGTTAGATTCGAATGCAAAACC
CAATAAGAAGGACCTCAGTGGAAACACGCCCCTCATTTACGCCTGCTCCGGTGGCCATCACGAGCTTGTGGCACTGCTGCTACAGCACGG
GGCCTCCATTAACGCTTCTAACAATAAGGGCAACACAGCGCTGCACGAGGCTGTGATTGAAAAGCACGTCTTCGTGGTAGAGCTGCTTCT
GCTCCACGGAGCGTCAGTTCAGGTGCTGAACAAGCGGCAGCGCACGGCTGTAGACTGTGCTGAACAGAATTCAAAAATAATGGAATTGCT
TCAGGTGGTACCAAGCTGTGTTGCTTCATTAGATGATGTGGCTGAAACTGACCGCAAGGAGTATGTCACTGTTAAGATCAGGAAAAAATG
GAACTCAAAACTGTATGATCTACCAGATGAGCCTTTTACAAGACAGTTTTACTTTGTCCACTCAGCTGGTCAGTTTAAGGGAAAGACTTC
AAGGGAGATTATGGCAAGAGATAGAAGTGTCCCTAATTTAACCGAAGGTTCTTTGCATGAGCCAGGGAGGCAAAGTGTCACACTGAGACA
GAATAACCTGCCAGCTCAGAGTGGATCTCATGCTGCTGAGAAAGGCAACAGCGACTGGCCAGAGAGGCCTGGACTGACACAGACTGGCCC
TGGACACAGACGGATGCTGCGGAGACACACGGTAGAGGATGCGGTCGTGTCCCAGGGCCCGGAGGCTGCTGGCCCCCTCTCCACTCCCCA
AGAGGTTAGTGCTTCCCGGTCCTAACAGGAATGAGGAGTTGTTGAACCCACTGCTAGGAAGCAAGGATGCAACAAGATGATGCTGAGCGT
GAACACATCTGAGAACTAAATGTGCTTCCATGAGACTGGCTTGAGAAGTCTTCAGCACCAAGTTCCTGAAAGCTTTTCTGTGGCAGGAAA
GAATGCAACAAAAAAGTTAACCACCACCATCTCTCTCCTCTTCAAAGCTAATGAATACAATTGAAACAGACAAAAATTCCAGTAGCATCC
AGATCCTTAAGCCAGAGGTGCATGCTTCTTTTTAAGTATGAGGGTTTGTTGGTCACAGTGGGAGAGGTTTCACCACCGCATTCTGACCTC
CTCCTCCCAAAAGGTGCTAAACCTCTCTGACCTGTGTACATTCACAAACCACAGCTAGAATTCCTCCACCTAGGATTAAGCTGGAGAGAA
GTAAGTAATTTAGGTTTCATGGTACTGTAGAGGCCAGGCTGAAATGTCATATCTGAAGGAAGAAAGCAGCAGCTGGACAATGTTTCTTTG
CAAAGCAACACTCGAACCAAAAGATGCCTCAATCCCATTTTGATATTCATTTTAGTGAAAGGATGCATCAGACCTGTTCCACATCATGCA
CATGGGAAAGGGTGGTTATCATTTTCCTTCTAACAAGTAGGTACAGATATTCGGTTACTACACGTGCACCTGTAGCAGTATTTCTAGAAA
CATCCCTTTTTGTTGAGAACCTCCCTTGAATGTCTGTCACACTCACACCTGACGGGATGGTTACTGGATTAGAGAGTAGATTTGGCACAT
CTTTTCTTAGTCTTTTGATTCAAATTCAAAACTTAACAGCACAAACCAGGTCAGAGTTACTTTCGGTTAGAATTTATTGCCATTTATTCC
TTTTTATAAATTTCTATAGATTATACTGTTATTTTTATGTTATTGGCCTAGAGCTACACGTATATGGGTTTGTCCTGAGTCCGTTTTCAA
ATGACCTTGTGATAGGGAAATGGTTTTGTCCATGTTCTTGGAAATACTTGTGTATGTACAGAAGGAAGGGAGGGATTATTTTTCTACAAA

>101838_101838_2_ZNF302-ANKRD27_ZNF302_chr19_35169718_ENST00000446502_ANKRD27_chr19_33098738_ENST00000306065_length(amino acids)=337AA_BP=10
MLAIGNCRIMSQRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKP
NKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELL
QVVPSCVASLDDVAETDRKEYVTVKIRKKWNSKLYDLPDEPFTRQFYFVHSAGQFKGKTSREIMARDRSVPNLTEGSLHEPGRQSVTLRQ

--------------------------------------------------------------
>101838_101838_3_ZNF302-ANKRD27_ZNF302_chr19_35169718_ENST00000457781_ANKRD27_chr19_33098738_ENST00000306065_length(transcript)=2365nt_BP=249nt
GTGGGCGGTGCACTGGGTCAGTCCCGCGATAGCTTCAGGCCTGGCGGCGGCTTCCAAGCTAAGGAACGGTTTGGGGCAGTGTCGTTCCCG
GAGGTCGGCCGCCGTTACCCGCTCACCAGCTACGCGGCGCGTCAGGTCCGCGGAGGCGCGGGCTCGGGGCGCCTGCGGGACGGACACTGC
CCATCTCTAAGATAAGAACCTGGAAAGGGGACTCTGTTGGCCATTGGAAATTGCAGAATAATGTCTCAGAGGCTGGCGAAGGTTCCTGCC
AGTGGGCTTGGTGTGAACGTGACCAGCCAGGACGGCTCCTCCCCGCTGCATGTCGCCGCCCTGCACGGCCGGGCGGACCTCATCCCCCTC
CTGCTGAAGCACGGGGCCAACGCAGGTGCCAGGAACGCAGACCAAGCCGTCCCGCTCCACCTGGCCTGCCAGCAGGGCCACTTTCAGGTG
GTGAAGTGTCTGTTAGATTCGAATGCAAAACCCAATAAGAAGGACCTCAGTGGAAACACGCCCCTCATTTACGCCTGCTCCGGTGGCCAT
CACGAGCTTGTGGCACTGCTGCTACAGCACGGGGCCTCCATTAACGCTTCTAACAATAAGGGCAACACAGCGCTGCACGAGGCTGTGATT
GAAAAGCACGTCTTCGTGGTAGAGCTGCTTCTGCTCCACGGAGCGTCAGTTCAGGTGCTGAACAAGCGGCAGCGCACGGCTGTAGACTGT
GCTGAACAGAATTCAAAAATAATGGAATTGCTTCAGGTGGTACCAAGCTGTGTTGCTTCATTAGATGATGTGGCTGAAACTGACCGCAAG
GAGTATGTCACTGTTAAGATCAGGAAAAAATGGAACTCAAAACTGTATGATCTACCAGATGAGCCTTTTACAAGACAGTTTTACTTTGTC
CACTCAGCTGGTCAGTTTAAGGGAAAGACTTCAAGGGAGATTATGGCAAGAGATAGAAGTGTCCCTAATTTAACCGAAGGTTCTTTGCAT
GAGCCAGGGAGGCAAAGTGTCACACTGAGACAGAATAACCTGCCAGCTCAGAGTGGATCTCATGCTGCTGAGAAAGGCAACAGCGACTGG
CCAGAGAGGCCTGGACTGACACAGACTGGCCCTGGACACAGACGGATGCTGCGGAGACACACGGTAGAGGATGCGGTCGTGTCCCAGGGC
CCGGAGGCTGCTGGCCCCCTCTCCACTCCCCAAGAGGTTAGTGCTTCCCGGTCCTAACAGGAATGAGGAGTTGTTGAACCCACTGCTAGG
AAGCAAGGATGCAACAAGATGATGCTGAGCGTGAACACATCTGAGAACTAAATGTGCTTCCATGAGACTGGCTTGAGAAGTCTTCAGCAC
CAAGTTCCTGAAAGCTTTTCTGTGGCAGGAAAGAATGCAACAAAAAAGTTAACCACCACCATCTCTCTCCTCTTCAAAGCTAATGAATAC
AATTGAAACAGACAAAAATTCCAGTAGCATCCAGATCCTTAAGCCAGAGGTGCATGCTTCTTTTTAAGTATGAGGGTTTGTTGGTCACAG
TGGGAGAGGTTTCACCACCGCATTCTGACCTCCTCCTCCCAAAAGGTGCTAAACCTCTCTGACCTGTGTACATTCACAAACCACAGCTAG
AATTCCTCCACCTAGGATTAAGCTGGAGAGAAGTAAGTAATTTAGGTTTCATGGTACTGTAGAGGCCAGGCTGAAATGTCATATCTGAAG
GAAGAAAGCAGCAGCTGGACAATGTTTCTTTGCAAAGCAACACTCGAACCAAAAGATGCCTCAATCCCATTTTGATATTCATTTTAGTGA
AAGGATGCATCAGACCTGTTCCACATCATGCACATGGGAAAGGGTGGTTATCATTTTCCTTCTAACAAGTAGGTACAGATATTCGGTTAC
TACACGTGCACCTGTAGCAGTATTTCTAGAAACATCCCTTTTTGTTGAGAACCTCCCTTGAATGTCTGTCACACTCACACCTGACGGGAT
GGTTACTGGATTAGAGAGTAGATTTGGCACATCTTTTCTTAGTCTTTTGATTCAAATTCAAAACTTAACAGCACAAACCAGGTCAGAGTT
ACTTTCGGTTAGAATTTATTGCCATTTATTCCTTTTTATAAATTTCTATAGATTATACTGTTATTTTTATGTTATTGGCCTAGAGCTACA
CGTATATGGGTTTGTCCTGAGTCCGTTTTCAAATGACCTTGTGATAGGGAAATGGTTTTGTCCATGTTCTTGGAAATACTTGTGTATGTA
CAGAAGGAAGGGAGGGATTATTTTTCTACAAAGTAATTTATGATTTCTAATTTTCTAATGTGCCTTGGATATGTGCCAAATGATGGAAAA

>101838_101838_3_ZNF302-ANKRD27_ZNF302_chr19_35169718_ENST00000457781_ANKRD27_chr19_33098738_ENST00000306065_length(amino acids)=337AA_BP=10
MLAIGNCRIMSQRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKP
NKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELL
QVVPSCVASLDDVAETDRKEYVTVKIRKKWNSKLYDLPDEPFTRQFYFVHSAGQFKGKTSREIMARDRSVPNLTEGSLHEPGRQSVTLRQ

--------------------------------------------------------------
>101838_101838_4_ZNF302-ANKRD27_ZNF302_chr19_35169718_ENST00000505242_ANKRD27_chr19_33098738_ENST00000306065_length(transcript)=2619nt_BP=503nt
GTCAGTCCCGCGATAGCTTCAGGCCTGGCGGCGGCTTCCAAGCTAAGGAACGGTTTGGGGCAGTGTCGTTCCCGGAGGTCGGCCGCCGTT
ACCCGCTCACCAGCTACGCGGCGCGTCAGGTCCGCGGAGGCGCGGGCTCGGGGCGCCTGCGGGACGGTGAGGCCCTGCTGAGGACTCCGG
CAAGTGTGGGTCGCGGCGACGGCGGGGCTAAGGCCCTGGGTCCGCGCGCGGTTTGACCACGGCCGGGGCCTTGGGCATTTCCTGGCCTTC
CTGTTGAGCCGTGTAAACGCGGGGTGATGACGGCGCCGACCTCTTGGCACTGTTGTGAGAGCGAAGTGGGCGCGAGAGCAGACGCCAGCT
ACAGTTTTTTTTGGGTTATGTCGTCATGAAGCCGGCGCTTTCAGTTGTGCAACCTTGAACAAATGGGACACTGCCCATCTCTAAGATAAG
AACCTGGAAAGGGGACTCTGTTGGCCATTGGAAATTGCAGAATAATGTCTCAGAGGCTGGCGAAGGTTCCTGCCAGTGGGCTTGGTGTGA
ACGTGACCAGCCAGGACGGCTCCTCCCCGCTGCATGTCGCCGCCCTGCACGGCCGGGCGGACCTCATCCCCCTCCTGCTGAAGCACGGGG
CCAACGCAGGTGCCAGGAACGCAGACCAAGCCGTCCCGCTCCACCTGGCCTGCCAGCAGGGCCACTTTCAGGTGGTGAAGTGTCTGTTAG
ATTCGAATGCAAAACCCAATAAGAAGGACCTCAGTGGAAACACGCCCCTCATTTACGCCTGCTCCGGTGGCCATCACGAGCTTGTGGCAC
TGCTGCTACAGCACGGGGCCTCCATTAACGCTTCTAACAATAAGGGCAACACAGCGCTGCACGAGGCTGTGATTGAAAAGCACGTCTTCG
TGGTAGAGCTGCTTCTGCTCCACGGAGCGTCAGTTCAGGTGCTGAACAAGCGGCAGCGCACGGCTGTAGACTGTGCTGAACAGAATTCAA
AAATAATGGAATTGCTTCAGGTGGTACCAAGCTGTGTTGCTTCATTAGATGATGTGGCTGAAACTGACCGCAAGGAGTATGTCACTGTTA
AGATCAGGAAAAAATGGAACTCAAAACTGTATGATCTACCAGATGAGCCTTTTACAAGACAGTTTTACTTTGTCCACTCAGCTGGTCAGT
TTAAGGGAAAGACTTCAAGGGAGATTATGGCAAGAGATAGAAGTGTCCCTAATTTAACCGAAGGTTCTTTGCATGAGCCAGGGAGGCAAA
GTGTCACACTGAGACAGAATAACCTGCCAGCTCAGAGTGGATCTCATGCTGCTGAGAAAGGCAACAGCGACTGGCCAGAGAGGCCTGGAC
TGACACAGACTGGCCCTGGACACAGACGGATGCTGCGGAGACACACGGTAGAGGATGCGGTCGTGTCCCAGGGCCCGGAGGCTGCTGGCC
CCCTCTCCACTCCCCAAGAGGTTAGTGCTTCCCGGTCCTAACAGGAATGAGGAGTTGTTGAACCCACTGCTAGGAAGCAAGGATGCAACA
AGATGATGCTGAGCGTGAACACATCTGAGAACTAAATGTGCTTCCATGAGACTGGCTTGAGAAGTCTTCAGCACCAAGTTCCTGAAAGCT
TTTCTGTGGCAGGAAAGAATGCAACAAAAAAGTTAACCACCACCATCTCTCTCCTCTTCAAAGCTAATGAATACAATTGAAACAGACAAA
AATTCCAGTAGCATCCAGATCCTTAAGCCAGAGGTGCATGCTTCTTTTTAAGTATGAGGGTTTGTTGGTCACAGTGGGAGAGGTTTCACC
ACCGCATTCTGACCTCCTCCTCCCAAAAGGTGCTAAACCTCTCTGACCTGTGTACATTCACAAACCACAGCTAGAATTCCTCCACCTAGG
ATTAAGCTGGAGAGAAGTAAGTAATTTAGGTTTCATGGTACTGTAGAGGCCAGGCTGAAATGTCATATCTGAAGGAAGAAAGCAGCAGCT
GGACAATGTTTCTTTGCAAAGCAACACTCGAACCAAAAGATGCCTCAATCCCATTTTGATATTCATTTTAGTGAAAGGATGCATCAGACC
TGTTCCACATCATGCACATGGGAAAGGGTGGTTATCATTTTCCTTCTAACAAGTAGGTACAGATATTCGGTTACTACACGTGCACCTGTA
GCAGTATTTCTAGAAACATCCCTTTTTGTTGAGAACCTCCCTTGAATGTCTGTCACACTCACACCTGACGGGATGGTTACTGGATTAGAG
AGTAGATTTGGCACATCTTTTCTTAGTCTTTTGATTCAAATTCAAAACTTAACAGCACAAACCAGGTCAGAGTTACTTTCGGTTAGAATT
TATTGCCATTTATTCCTTTTTATAAATTTCTATAGATTATACTGTTATTTTTATGTTATTGGCCTAGAGCTACACGTATATGGGTTTGTC
CTGAGTCCGTTTTCAAATGACCTTGTGATAGGGAAATGGTTTTGTCCATGTTCTTGGAAATACTTGTGTATGTACAGAAGGAAGGGAGGG
ATTATTTTTCTACAAAGTAATTTATGATTTCTAATTTTCTAATGTGCCTTGGATATGTGCCAAATGATGGAAAAGAAACAGTAAACTTTA

>101838_101838_4_ZNF302-ANKRD27_ZNF302_chr19_35169718_ENST00000505242_ANKRD27_chr19_33098738_ENST00000306065_length(amino acids)=337AA_BP=10
MLAIGNCRIMSQRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKP
NKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELL
QVVPSCVASLDDVAETDRKEYVTVKIRKKWNSKLYDLPDEPFTRQFYFVHSAGQFKGKTSREIMARDRSVPNLTEGSLHEPGRQSVTLRQ

--------------------------------------------------------------
>101838_101838_5_ZNF302-ANKRD27_ZNF302_chr19_35169718_ENST00000505365_ANKRD27_chr19_33098738_ENST00000306065_length(transcript)=2461nt_BP=345nt
GAGGCCCTGCTGAGGACTCCGGCAAGTGTGGGTCGCGGCGACGGCGGGGCTAAGGCCCTGGGTCCGCGCGCGGTTTGACCACGGCCGGGG
CCTTGGGCATTTCCTGGCCTTCCTGTTGAGCCGTGTAAACGCGGGGTGATGACGGCGCCGACCTCTTGGCACTGTTGTGAGAGCGAAGTG
GGCGCGAGAGCAGACGCCAGCTACAGTTTTTTTTGGGTTATGTCGTCATGAAGCCGGCGCTTTCAGTTGTGCAACCTTGAACAAATGGGA
CACTGCCCATCTCTAAGATAAGAACCTGGAAAGGGGACTCTGTTGGCCATTGGAAATTGCAGAATAATGTCTCAGAGGCTGGCGAAGGTT
CCTGCCAGTGGGCTTGGTGTGAACGTGACCAGCCAGGACGGCTCCTCCCCGCTGCATGTCGCCGCCCTGCACGGCCGGGCGGACCTCATC
CCCCTCCTGCTGAAGCACGGGGCCAACGCAGGTGCCAGGAACGCAGACCAAGCCGTCCCGCTCCACCTGGCCTGCCAGCAGGGCCACTTT
CAGGTGGTGAAGTGTCTGTTAGATTCGAATGCAAAACCCAATAAGAAGGACCTCAGTGGAAACACGCCCCTCATTTACGCCTGCTCCGGT
GGCCATCACGAGCTTGTGGCACTGCTGCTACAGCACGGGGCCTCCATTAACGCTTCTAACAATAAGGGCAACACAGCGCTGCACGAGGCT
GTGATTGAAAAGCACGTCTTCGTGGTAGAGCTGCTTCTGCTCCACGGAGCGTCAGTTCAGGTGCTGAACAAGCGGCAGCGCACGGCTGTA
GACTGTGCTGAACAGAATTCAAAAATAATGGAATTGCTTCAGGTGGTACCAAGCTGTGTTGCTTCATTAGATGATGTGGCTGAAACTGAC
CGCAAGGAGTATGTCACTGTTAAGATCAGGAAAAAATGGAACTCAAAACTGTATGATCTACCAGATGAGCCTTTTACAAGACAGTTTTAC
TTTGTCCACTCAGCTGGTCAGTTTAAGGGAAAGACTTCAAGGGAGATTATGGCAAGAGATAGAAGTGTCCCTAATTTAACCGAAGGTTCT
TTGCATGAGCCAGGGAGGCAAAGTGTCACACTGAGACAGAATAACCTGCCAGCTCAGAGTGGATCTCATGCTGCTGAGAAAGGCAACAGC
GACTGGCCAGAGAGGCCTGGACTGACACAGACTGGCCCTGGACACAGACGGATGCTGCGGAGACACACGGTAGAGGATGCGGTCGTGTCC
CAGGGCCCGGAGGCTGCTGGCCCCCTCTCCACTCCCCAAGAGGTTAGTGCTTCCCGGTCCTAACAGGAATGAGGAGTTGTTGAACCCACT
GCTAGGAAGCAAGGATGCAACAAGATGATGCTGAGCGTGAACACATCTGAGAACTAAATGTGCTTCCATGAGACTGGCTTGAGAAGTCTT
CAGCACCAAGTTCCTGAAAGCTTTTCTGTGGCAGGAAAGAATGCAACAAAAAAGTTAACCACCACCATCTCTCTCCTCTTCAAAGCTAAT
GAATACAATTGAAACAGACAAAAATTCCAGTAGCATCCAGATCCTTAAGCCAGAGGTGCATGCTTCTTTTTAAGTATGAGGGTTTGTTGG
TCACAGTGGGAGAGGTTTCACCACCGCATTCTGACCTCCTCCTCCCAAAAGGTGCTAAACCTCTCTGACCTGTGTACATTCACAAACCAC
AGCTAGAATTCCTCCACCTAGGATTAAGCTGGAGAGAAGTAAGTAATTTAGGTTTCATGGTACTGTAGAGGCCAGGCTGAAATGTCATAT
CTGAAGGAAGAAAGCAGCAGCTGGACAATGTTTCTTTGCAAAGCAACACTCGAACCAAAAGATGCCTCAATCCCATTTTGATATTCATTT
TAGTGAAAGGATGCATCAGACCTGTTCCACATCATGCACATGGGAAAGGGTGGTTATCATTTTCCTTCTAACAAGTAGGTACAGATATTC
GGTTACTACACGTGCACCTGTAGCAGTATTTCTAGAAACATCCCTTTTTGTTGAGAACCTCCCTTGAATGTCTGTCACACTCACACCTGA
CGGGATGGTTACTGGATTAGAGAGTAGATTTGGCACATCTTTTCTTAGTCTTTTGATTCAAATTCAAAACTTAACAGCACAAACCAGGTC
AGAGTTACTTTCGGTTAGAATTTATTGCCATTTATTCCTTTTTATAAATTTCTATAGATTATACTGTTATTTTTATGTTATTGGCCTAGA
GCTACACGTATATGGGTTTGTCCTGAGTCCGTTTTCAAATGACCTTGTGATAGGGAAATGGTTTTGTCCATGTTCTTGGAAATACTTGTG
TATGTACAGAAGGAAGGGAGGGATTATTTTTCTACAAAGTAATTTATGATTTCTAATTTTCTAATGTGCCTTGGATATGTGCCAAATGAT

>101838_101838_5_ZNF302-ANKRD27_ZNF302_chr19_35169718_ENST00000505365_ANKRD27_chr19_33098738_ENST00000306065_length(amino acids)=337AA_BP=10
MLAIGNCRIMSQRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKP
NKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELL
QVVPSCVASLDDVAETDRKEYVTVKIRKKWNSKLYDLPDEPFTRQFYFVHSAGQFKGKTSREIMARDRSVPNLTEGSLHEPGRQSVTLRQ

--------------------------------------------------------------
>101838_101838_6_ZNF302-ANKRD27_ZNF302_chr19_35169718_ENST00000507959_ANKRD27_chr19_33098738_ENST00000306065_length(transcript)=2348nt_BP=232nt
CTGGCGGCGGCTTCCAAGCTAAGGAACGGTTTGGGGCAGTGTCGTTCCCGGAGGTCGGCCGCCGTTACCCGCTCACCAGCTACGCGGCGC
GTCAGGTCCGCGGAGGCGCGGGCTCGGGGCGCCTGCGGGACGGTGAGGCCCTGCTGAGGACTCCGGACACTGCCCATCTCTAAGATAAGA
ACCTGGAAAGGGGACTCTGTTGGCCATTGGAAATTGCAGAATAATGTCTCAGAGGCTGGCGAAGGTTCCTGCCAGTGGGCTTGGTGTGAA
CGTGACCAGCCAGGACGGCTCCTCCCCGCTGCATGTCGCCGCCCTGCACGGCCGGGCGGACCTCATCCCCCTCCTGCTGAAGCACGGGGC
CAACGCAGGTGCCAGGAACGCAGACCAAGCCGTCCCGCTCCACCTGGCCTGCCAGCAGGGCCACTTTCAGGTGGTGAAGTGTCTGTTAGA
TTCGAATGCAAAACCCAATAAGAAGGACCTCAGTGGAAACACGCCCCTCATTTACGCCTGCTCCGGTGGCCATCACGAGCTTGTGGCACT
GCTGCTACAGCACGGGGCCTCCATTAACGCTTCTAACAATAAGGGCAACACAGCGCTGCACGAGGCTGTGATTGAAAAGCACGTCTTCGT
GGTAGAGCTGCTTCTGCTCCACGGAGCGTCAGTTCAGGTGCTGAACAAGCGGCAGCGCACGGCTGTAGACTGTGCTGAACAGAATTCAAA
AATAATGGAATTGCTTCAGGTGGTACCAAGCTGTGTTGCTTCATTAGATGATGTGGCTGAAACTGACCGCAAGGAGTATGTCACTGTTAA
GATCAGGAAAAAATGGAACTCAAAACTGTATGATCTACCAGATGAGCCTTTTACAAGACAGTTTTACTTTGTCCACTCAGCTGGTCAGTT
TAAGGGAAAGACTTCAAGGGAGATTATGGCAAGAGATAGAAGTGTCCCTAATTTAACCGAAGGTTCTTTGCATGAGCCAGGGAGGCAAAG
TGTCACACTGAGACAGAATAACCTGCCAGCTCAGAGTGGATCTCATGCTGCTGAGAAAGGCAACAGCGACTGGCCAGAGAGGCCTGGACT
GACACAGACTGGCCCTGGACACAGACGGATGCTGCGGAGACACACGGTAGAGGATGCGGTCGTGTCCCAGGGCCCGGAGGCTGCTGGCCC
CCTCTCCACTCCCCAAGAGGTTAGTGCTTCCCGGTCCTAACAGGAATGAGGAGTTGTTGAACCCACTGCTAGGAAGCAAGGATGCAACAA
GATGATGCTGAGCGTGAACACATCTGAGAACTAAATGTGCTTCCATGAGACTGGCTTGAGAAGTCTTCAGCACCAAGTTCCTGAAAGCTT
TTCTGTGGCAGGAAAGAATGCAACAAAAAAGTTAACCACCACCATCTCTCTCCTCTTCAAAGCTAATGAATACAATTGAAACAGACAAAA
ATTCCAGTAGCATCCAGATCCTTAAGCCAGAGGTGCATGCTTCTTTTTAAGTATGAGGGTTTGTTGGTCACAGTGGGAGAGGTTTCACCA
CCGCATTCTGACCTCCTCCTCCCAAAAGGTGCTAAACCTCTCTGACCTGTGTACATTCACAAACCACAGCTAGAATTCCTCCACCTAGGA
TTAAGCTGGAGAGAAGTAAGTAATTTAGGTTTCATGGTACTGTAGAGGCCAGGCTGAAATGTCATATCTGAAGGAAGAAAGCAGCAGCTG
GACAATGTTTCTTTGCAAAGCAACACTCGAACCAAAAGATGCCTCAATCCCATTTTGATATTCATTTTAGTGAAAGGATGCATCAGACCT
GTTCCACATCATGCACATGGGAAAGGGTGGTTATCATTTTCCTTCTAACAAGTAGGTACAGATATTCGGTTACTACACGTGCACCTGTAG
CAGTATTTCTAGAAACATCCCTTTTTGTTGAGAACCTCCCTTGAATGTCTGTCACACTCACACCTGACGGGATGGTTACTGGATTAGAGA
GTAGATTTGGCACATCTTTTCTTAGTCTTTTGATTCAAATTCAAAACTTAACAGCACAAACCAGGTCAGAGTTACTTTCGGTTAGAATTT
ATTGCCATTTATTCCTTTTTATAAATTTCTATAGATTATACTGTTATTTTTATGTTATTGGCCTAGAGCTACACGTATATGGGTTTGTCC
TGAGTCCGTTTTCAAATGACCTTGTGATAGGGAAATGGTTTTGTCCATGTTCTTGGAAATACTTGTGTATGTACAGAAGGAAGGGAGGGA
TTATTTTTCTACAAAGTAATTTATGATTTCTAATTTTCTAATGTGCCTTGGATATGTGCCAAATGATGGAAAAGAAACAGTAAACTTTAT

>101838_101838_6_ZNF302-ANKRD27_ZNF302_chr19_35169718_ENST00000507959_ANKRD27_chr19_33098738_ENST00000306065_length(amino acids)=337AA_BP=10
MLAIGNCRIMSQRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKP
NKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELL
QVVPSCVASLDDVAETDRKEYVTVKIRKKWNSKLYDLPDEPFTRQFYFVHSAGQFKGKTSREIMARDRSVPNLTEGSLHEPGRQSVTLRQ

--------------------------------------------------------------
>101838_101838_7_ZNF302-ANKRD27_ZNF302_chr19_35169718_ENST00000509528_ANKRD27_chr19_33098738_ENST00000306065_length(transcript)=2403nt_BP=287nt
GAAATGTGGTTCGCCGTGGGCGGTGCACTGGGTCAGTCCCGCGATAGCTTCAGGCCTGGCGGCGGCTTCCAAGCTAAGGAACGGTTTGGG
GCAGTGTCGTTCCCGGAGGTCGGCCGCCGTTACCCGCTCACCAGCTACGCGGCGCGTCAGGTCCGCGGAGGCGCGGGCTCGGGGCGCCTG
CGGGACGGTGAGGCCCTGCTGAGGACTCCGGACACTGCCCATCTCTAAGATAAGAACCTGGAAAGGGGACTCTGTTGGCCATTGGAAATT
GCAGAATAATGTCTCAGAGGCTGGCGAAGGTTCCTGCCAGTGGGCTTGGTGTGAACGTGACCAGCCAGGACGGCTCCTCCCCGCTGCATG
TCGCCGCCCTGCACGGCCGGGCGGACCTCATCCCCCTCCTGCTGAAGCACGGGGCCAACGCAGGTGCCAGGAACGCAGACCAAGCCGTCC
CGCTCCACCTGGCCTGCCAGCAGGGCCACTTTCAGGTGGTGAAGTGTCTGTTAGATTCGAATGCAAAACCCAATAAGAAGGACCTCAGTG
GAAACACGCCCCTCATTTACGCCTGCTCCGGTGGCCATCACGAGCTTGTGGCACTGCTGCTACAGCACGGGGCCTCCATTAACGCTTCTA
ACAATAAGGGCAACACAGCGCTGCACGAGGCTGTGATTGAAAAGCACGTCTTCGTGGTAGAGCTGCTTCTGCTCCACGGAGCGTCAGTTC
AGGTGCTGAACAAGCGGCAGCGCACGGCTGTAGACTGTGCTGAACAGAATTCAAAAATAATGGAATTGCTTCAGGTGGTACCAAGCTGTG
TTGCTTCATTAGATGATGTGGCTGAAACTGACCGCAAGGAGTATGTCACTGTTAAGATCAGGAAAAAATGGAACTCAAAACTGTATGATC
TACCAGATGAGCCTTTTACAAGACAGTTTTACTTTGTCCACTCAGCTGGTCAGTTTAAGGGAAAGACTTCAAGGGAGATTATGGCAAGAG
ATAGAAGTGTCCCTAATTTAACCGAAGGTTCTTTGCATGAGCCAGGGAGGCAAAGTGTCACACTGAGACAGAATAACCTGCCAGCTCAGA
GTGGATCTCATGCTGCTGAGAAAGGCAACAGCGACTGGCCAGAGAGGCCTGGACTGACACAGACTGGCCCTGGACACAGACGGATGCTGC
GGAGACACACGGTAGAGGATGCGGTCGTGTCCCAGGGCCCGGAGGCTGCTGGCCCCCTCTCCACTCCCCAAGAGGTTAGTGCTTCCCGGT
CCTAACAGGAATGAGGAGTTGTTGAACCCACTGCTAGGAAGCAAGGATGCAACAAGATGATGCTGAGCGTGAACACATCTGAGAACTAAA
TGTGCTTCCATGAGACTGGCTTGAGAAGTCTTCAGCACCAAGTTCCTGAAAGCTTTTCTGTGGCAGGAAAGAATGCAACAAAAAAGTTAA
CCACCACCATCTCTCTCCTCTTCAAAGCTAATGAATACAATTGAAACAGACAAAAATTCCAGTAGCATCCAGATCCTTAAGCCAGAGGTG
CATGCTTCTTTTTAAGTATGAGGGTTTGTTGGTCACAGTGGGAGAGGTTTCACCACCGCATTCTGACCTCCTCCTCCCAAAAGGTGCTAA
ACCTCTCTGACCTGTGTACATTCACAAACCACAGCTAGAATTCCTCCACCTAGGATTAAGCTGGAGAGAAGTAAGTAATTTAGGTTTCAT
GGTACTGTAGAGGCCAGGCTGAAATGTCATATCTGAAGGAAGAAAGCAGCAGCTGGACAATGTTTCTTTGCAAAGCAACACTCGAACCAA
AAGATGCCTCAATCCCATTTTGATATTCATTTTAGTGAAAGGATGCATCAGACCTGTTCCACATCATGCACATGGGAAAGGGTGGTTATC
ATTTTCCTTCTAACAAGTAGGTACAGATATTCGGTTACTACACGTGCACCTGTAGCAGTATTTCTAGAAACATCCCTTTTTGTTGAGAAC
CTCCCTTGAATGTCTGTCACACTCACACCTGACGGGATGGTTACTGGATTAGAGAGTAGATTTGGCACATCTTTTCTTAGTCTTTTGATT
CAAATTCAAAACTTAACAGCACAAACCAGGTCAGAGTTACTTTCGGTTAGAATTTATTGCCATTTATTCCTTTTTATAAATTTCTATAGA
TTATACTGTTATTTTTATGTTATTGGCCTAGAGCTACACGTATATGGGTTTGTCCTGAGTCCGTTTTCAAATGACCTTGTGATAGGGAAA
TGGTTTTGTCCATGTTCTTGGAAATACTTGTGTATGTACAGAAGGAAGGGAGGGATTATTTTTCTACAAAGTAATTTATGATTTCTAATT

>101838_101838_7_ZNF302-ANKRD27_ZNF302_chr19_35169718_ENST00000509528_ANKRD27_chr19_33098738_ENST00000306065_length(amino acids)=337AA_BP=10
MLAIGNCRIMSQRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKP
NKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELL
QVVPSCVASLDDVAETDRKEYVTVKIRKKWNSKLYDLPDEPFTRQFYFVHSAGQFKGKTSREIMARDRSVPNLTEGSLHEPGRQSVTLRQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZNF302-ANKRD27


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneANKRD27chr19:35169718chr19:33098738ENST000003060652129451_730725.01051.0RAB32
TgeneANKRD27chr19:35169718chr19:33098738ENST000003060652129451_600725.01051.0RAB38


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF302-ANKRD27


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF302-ANKRD27


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource