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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF384-CDCA3 (FusionGDB2 ID:101951)

Fusion Gene Summary for ZNF384-CDCA3

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF384-CDCA3
Fusion gene ID: 101951
HgeneTgene
Gene symbol

ZNF384

CDCA3

Gene ID

171017

83461

Gene namezinc finger protein 384cell division cycle associated 3
SynonymsCAGH1|CAGH1A|CIZ|ERDA2|NMP4|NP|TNRC1GRCC8|TOME-1
Cytomap

12p13.31

12p13.31

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 384CAG repeat protein 1Cas-interacting zinc finger proteinexpanded repeat domain, CAG/CTG 2nuclear matrix transcription factor 4trinucleotide repeat-containing gene 1 proteincell division cycle-associated protein 3gene-rich cluster protein C8trigger of mitotic entry protein 1
Modification date2020031320200313
UniProtAcc.

Q99618

Ensembl transtripts involved in fusion geneENST00000319770, ENST00000355772, 
ENST00000361959, ENST00000396795, 
ENST00000396799, ENST00000396801, 
ENST00000229265, ENST00000535406, 
ENST00000538862, ENST00000540683, 
ENST00000604599, ENST00000422785, 
Fusion gene scores* DoF score5 X 5 X 3=751 X 1 X 1=1
# samples 51
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: ZNF384 [Title/Abstract] AND CDCA3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF384(6778197)-CDCA3(6958828), # samples:2
Anticipated loss of major functional domain due to fusion event.ZNF384-CDCA3 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
ZNF384-CDCA3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ZNF384-CDCA3 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ZNF384-CDCA3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ZNF384 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CDCA3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-C5-A7X3-01AZNF384chr12

6778197

-CDCA3chr12

6958828

-


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Fusion Gene ORF analysis for ZNF384-CDCA3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000319770ENST00000229265ZNF384chr12

6778197

-CDCA3chr12

6958828

-
5CDS-intronENST00000319770ENST00000535406ZNF384chr12

6778197

-CDCA3chr12

6958828

-
5CDS-intronENST00000319770ENST00000538862ZNF384chr12

6778197

-CDCA3chr12

6958828

-
5CDS-intronENST00000319770ENST00000540683ZNF384chr12

6778197

-CDCA3chr12

6958828

-
5CDS-intronENST00000319770ENST00000604599ZNF384chr12

6778197

-CDCA3chr12

6958828

-
5CDS-intronENST00000355772ENST00000229265ZNF384chr12

6778197

-CDCA3chr12

6958828

-
5CDS-intronENST00000355772ENST00000535406ZNF384chr12

6778197

-CDCA3chr12

6958828

-
5CDS-intronENST00000355772ENST00000538862ZNF384chr12

6778197

-CDCA3chr12

6958828

-
5CDS-intronENST00000355772ENST00000540683ZNF384chr12

6778197

-CDCA3chr12

6958828

-
5CDS-intronENST00000355772ENST00000604599ZNF384chr12

6778197

-CDCA3chr12

6958828

-
5CDS-intronENST00000361959ENST00000229265ZNF384chr12

6778197

-CDCA3chr12

6958828

-
5CDS-intronENST00000361959ENST00000535406ZNF384chr12

6778197

-CDCA3chr12

6958828

-
5CDS-intronENST00000361959ENST00000538862ZNF384chr12

6778197

-CDCA3chr12

6958828

-
5CDS-intronENST00000361959ENST00000540683ZNF384chr12

6778197

-CDCA3chr12

6958828

-
5CDS-intronENST00000361959ENST00000604599ZNF384chr12

6778197

-CDCA3chr12

6958828

-
5CDS-intronENST00000396795ENST00000229265ZNF384chr12

6778197

-CDCA3chr12

6958828

-
5CDS-intronENST00000396795ENST00000535406ZNF384chr12

6778197

-CDCA3chr12

6958828

-
5CDS-intronENST00000396795ENST00000538862ZNF384chr12

6778197

-CDCA3chr12

6958828

-
5CDS-intronENST00000396795ENST00000540683ZNF384chr12

6778197

-CDCA3chr12

6958828

-
5CDS-intronENST00000396795ENST00000604599ZNF384chr12

6778197

-CDCA3chr12

6958828

-
5CDS-intronENST00000396799ENST00000229265ZNF384chr12

6778197

-CDCA3chr12

6958828

-
5CDS-intronENST00000396799ENST00000535406ZNF384chr12

6778197

-CDCA3chr12

6958828

-
5CDS-intronENST00000396799ENST00000538862ZNF384chr12

6778197

-CDCA3chr12

6958828

-
5CDS-intronENST00000396799ENST00000540683ZNF384chr12

6778197

-CDCA3chr12

6958828

-
5CDS-intronENST00000396799ENST00000604599ZNF384chr12

6778197

-CDCA3chr12

6958828

-
5CDS-intronENST00000396801ENST00000229265ZNF384chr12

6778197

-CDCA3chr12

6958828

-
5CDS-intronENST00000396801ENST00000535406ZNF384chr12

6778197

-CDCA3chr12

6958828

-
5CDS-intronENST00000396801ENST00000538862ZNF384chr12

6778197

-CDCA3chr12

6958828

-
5CDS-intronENST00000396801ENST00000540683ZNF384chr12

6778197

-CDCA3chr12

6958828

-
5CDS-intronENST00000396801ENST00000604599ZNF384chr12

6778197

-CDCA3chr12

6958828

-
Frame-shiftENST00000396795ENST00000422785ZNF384chr12

6778197

-CDCA3chr12

6958828

-
In-frameENST00000319770ENST00000422785ZNF384chr12

6778197

-CDCA3chr12

6958828

-
In-frameENST00000355772ENST00000422785ZNF384chr12

6778197

-CDCA3chr12

6958828

-
In-frameENST00000361959ENST00000422785ZNF384chr12

6778197

-CDCA3chr12

6958828

-
In-frameENST00000396799ENST00000422785ZNF384chr12

6778197

-CDCA3chr12

6958828

-
In-frameENST00000396801ENST00000422785ZNF384chr12

6778197

-CDCA3chr12

6958828

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000319770ZNF384chr126778197-ENST00000422785CDCA3chr126958828-36411430531612519
ENST00000396801ZNF384chr126778197-ENST00000422785CDCA3chr126958828-375115401031722539
ENST00000361959ZNF384chr126778197-ENST00000422785CDCA3chr126958828-38031592591774571
ENST00000355772ZNF384chr126778197-ENST00000422785CDCA3chr126958828-33471136471318423
ENST00000396799ZNF384chr126778197-ENST00000422785CDCA3chr126958828-383816271031809568

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000319770ENST00000422785ZNF384chr126778197-CDCA3chr126958828-0.0388078650.96119213
ENST00000396801ENST00000422785ZNF384chr126778197-CDCA3chr126958828-0.0613478120.9386522
ENST00000361959ENST00000422785ZNF384chr126778197-CDCA3chr126958828-0.0578287580.9421713
ENST00000355772ENST00000422785ZNF384chr126778197-CDCA3chr126958828-0.055635560.9443644
ENST00000396799ENST00000422785ZNF384chr126778197-CDCA3chr126958828-0.06409360.9359064

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Fusion Genomic Features for ZNF384-CDCA3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF384-CDCA3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:6778197/chr12:6958828)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CDCA3

Q99618

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF384chr12:6778197chr12:6958828ENST00000355772-89228_250328462.0Zinc fingerC2H2-type 1
HgeneZNF384chr12:6778197chr12:6958828ENST00000355772-89256_278328462.0Zinc fingerC2H2-type 2
HgeneZNF384chr12:6778197chr12:6958828ENST00000355772-89284_306328462.0Zinc fingerC2H2-type 3
HgeneZNF384chr12:6778197chr12:6958828ENST00000361959-1011228_250444578.0Zinc fingerC2H2-type 1
HgeneZNF384chr12:6778197chr12:6958828ENST00000361959-1011256_278444578.0Zinc fingerC2H2-type 2
HgeneZNF384chr12:6778197chr12:6958828ENST00000361959-1011284_306444578.0Zinc fingerC2H2-type 3
HgeneZNF384chr12:6778197chr12:6958828ENST00000361959-1011317_339444578.0Zinc fingerC2H2-type 4
HgeneZNF384chr12:6778197chr12:6958828ENST00000361959-1011345_367444578.0Zinc fingerC2H2-type 5
HgeneZNF384chr12:6778197chr12:6958828ENST00000361959-1011373_397444578.0Zinc fingerC2H2-type 6
HgeneZNF384chr12:6778197chr12:6958828ENST00000361959-1011403_425444578.0Zinc fingerC2H2-type 7
HgeneZNF384chr12:6778197chr12:6958828ENST00000396795-89228_250383517.0Zinc fingerC2H2-type 1
HgeneZNF384chr12:6778197chr12:6958828ENST00000396795-89256_278383517.0Zinc fingerC2H2-type 2
HgeneZNF384chr12:6778197chr12:6958828ENST00000396795-89284_306383517.0Zinc fingerC2H2-type 3
HgeneZNF384chr12:6778197chr12:6958828ENST00000396795-89317_339383517.0Zinc fingerC2H2-type 4
HgeneZNF384chr12:6778197chr12:6958828ENST00000396795-89345_367383517.0Zinc fingerC2H2-type 5
HgeneZNF384chr12:6778197chr12:6958828ENST00000396799-910228_250383517.0Zinc fingerC2H2-type 1
HgeneZNF384chr12:6778197chr12:6958828ENST00000396799-910256_278383517.0Zinc fingerC2H2-type 2
HgeneZNF384chr12:6778197chr12:6958828ENST00000396799-910284_306383517.0Zinc fingerC2H2-type 3
HgeneZNF384chr12:6778197chr12:6958828ENST00000396799-910317_339383517.0Zinc fingerC2H2-type 4
HgeneZNF384chr12:6778197chr12:6958828ENST00000396799-910345_367383517.0Zinc fingerC2H2-type 5
HgeneZNF384chr12:6778197chr12:6958828ENST00000396801-1011228_250444578.0Zinc fingerC2H2-type 1
HgeneZNF384chr12:6778197chr12:6958828ENST00000396801-1011256_278444578.0Zinc fingerC2H2-type 2
HgeneZNF384chr12:6778197chr12:6958828ENST00000396801-1011284_306444578.0Zinc fingerC2H2-type 3
HgeneZNF384chr12:6778197chr12:6958828ENST00000396801-1011317_339444578.0Zinc fingerC2H2-type 4
HgeneZNF384chr12:6778197chr12:6958828ENST00000396801-1011345_367444578.0Zinc fingerC2H2-type 5
HgeneZNF384chr12:6778197chr12:6958828ENST00000396801-1011373_397444578.0Zinc fingerC2H2-type 6
HgeneZNF384chr12:6778197chr12:6958828ENST00000396801-1011403_425444578.0Zinc fingerC2H2-type 7
TgeneCDCA3chr12:6778197chr12:6958828ENST0000053540605258_2600269.0MotifNote=KEN box
TgeneCDCA3chr12:6778197chr12:6958828ENST0000053886206258_2600269.0MotifNote=KEN box
TgeneCDCA3chr12:6778197chr12:6958828ENST000005354060591_1200269.0RegionNote=F-box-like
TgeneCDCA3chr12:6778197chr12:6958828ENST000005388620691_1200269.0RegionNote=F-box-like

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF384chr12:6778197chr12:6958828ENST00000355772-89461_521328462.0Compositional biasNote=Gln-rich
HgeneZNF384chr12:6778197chr12:6958828ENST00000355772-89466_499328462.0Compositional biasNote=Ala-rich
HgeneZNF384chr12:6778197chr12:6958828ENST00000361959-1011461_521444578.0Compositional biasNote=Gln-rich
HgeneZNF384chr12:6778197chr12:6958828ENST00000361959-1011466_499444578.0Compositional biasNote=Ala-rich
HgeneZNF384chr12:6778197chr12:6958828ENST00000396795-89461_521383517.0Compositional biasNote=Gln-rich
HgeneZNF384chr12:6778197chr12:6958828ENST00000396795-89466_499383517.0Compositional biasNote=Ala-rich
HgeneZNF384chr12:6778197chr12:6958828ENST00000396799-910461_521383517.0Compositional biasNote=Gln-rich
HgeneZNF384chr12:6778197chr12:6958828ENST00000396799-910466_499383517.0Compositional biasNote=Ala-rich
HgeneZNF384chr12:6778197chr12:6958828ENST00000396801-1011461_521444578.0Compositional biasNote=Gln-rich
HgeneZNF384chr12:6778197chr12:6958828ENST00000396801-1011466_499444578.0Compositional biasNote=Ala-rich
HgeneZNF384chr12:6778197chr12:6958828ENST00000355772-89317_339328462.0Zinc fingerC2H2-type 4
HgeneZNF384chr12:6778197chr12:6958828ENST00000355772-89345_367328462.0Zinc fingerC2H2-type 5
HgeneZNF384chr12:6778197chr12:6958828ENST00000355772-89373_397328462.0Zinc fingerC2H2-type 6
HgeneZNF384chr12:6778197chr12:6958828ENST00000355772-89403_425328462.0Zinc fingerC2H2-type 7
HgeneZNF384chr12:6778197chr12:6958828ENST00000355772-89433_455328462.0Zinc fingerC2H2-type 8
HgeneZNF384chr12:6778197chr12:6958828ENST00000361959-1011433_455444578.0Zinc fingerC2H2-type 8
HgeneZNF384chr12:6778197chr12:6958828ENST00000396795-89373_397383517.0Zinc fingerC2H2-type 6
HgeneZNF384chr12:6778197chr12:6958828ENST00000396795-89403_425383517.0Zinc fingerC2H2-type 7
HgeneZNF384chr12:6778197chr12:6958828ENST00000396795-89433_455383517.0Zinc fingerC2H2-type 8
HgeneZNF384chr12:6778197chr12:6958828ENST00000396799-910373_397383517.0Zinc fingerC2H2-type 6
HgeneZNF384chr12:6778197chr12:6958828ENST00000396799-910403_425383517.0Zinc fingerC2H2-type 7
HgeneZNF384chr12:6778197chr12:6958828ENST00000396799-910433_455383517.0Zinc fingerC2H2-type 8
HgeneZNF384chr12:6778197chr12:6958828ENST00000396801-1011433_455444578.0Zinc fingerC2H2-type 8


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Fusion Gene Sequence for ZNF384-CDCA3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>101951_101951_1_ZNF384-CDCA3_ZNF384_chr12_6778197_ENST00000319770_CDCA3_chr12_6958828_ENST00000422785_length(transcript)=3641nt_BP=1430nt
GCAAGGGGAGGGCAGCAAGGAGGGGGGGCCACCCACTACCTCGCGCCCCCGCCCTGCGGGTGTCTCGCGCGCGTTCCGTGCGTGTGAGTG
TGTGGGTCTGTCTCGCTCCAGAAGTGCGTGCCCGCGCGCTGCGCCTTGCGCTTTTTCCCCTCCCTCGCCCCTTCCTGGTCCTCCCACCCT
CCTCGGCTCCCTCCTTTCCCAGCAAACGCCGCCCCTCCCGCGCCCTGGCTCAGGCTCTGGCGCCGCCGCAGCCGTCGCCGCCCGAAAGTT
CAGGAGCCCTGGAAAGGAGAAGGAATAAGACGGCAGGAGGAAGAGAGAGAGAGGGTAGAATGGAAGAATCTCACTTCAATTCTAACCCGT
ACTTCTGGCCTTCTATCCCCACAGTCTCAGGTCAGATCGAGAACACAATGTTCATCAACAAGATGAAGGATCAGCTGTTGCCAGAGAAGG
GCTGTGGTCTGGCCCCACCTCACTACCCCACCTTGCTGACAGTGCCTGCCTCAGTGTCCCTGCCCTCAGGCATCAGTATGGACACAGAGT
CCAAGTCAGACCAGCTGACCCCACACAGCCAAGCGTCCGTTACCCAGAATATCACGGTGGTCCCTGTGCCGTCTACAGGACTGATGACTG
CTGGTCCGGGTTTGGTAATCACGTCCCCCTCAGGCTCTCTTGTGACCACAGCATCATCAGCTCAGACCTTCCCCATTTCGGCTCCCATGA
TTGTCTCAGCTCTTCCCCCTGGCTCACAAGCCCTGCAGGTTGTCCCTGACCTCTCCAAGAAGGTAGCATCGACCCTAACCGAGGAAGGAG
GCGGAGGTGGTGGTGGAGGTGGCAGTGTGGCTCCTAAGCCACCCCGGGGCCGGAAGAAGAAGCGGATGCTGGAATCAGGGCTGCCCGAGA
TGAATGACCCTTATGTCCTCTCCCCTGAGGATGATGATGACCATCAGAAAGACGGCAAGACCTACAGGTGCCGGATGTGCTCACTGACAT
TCTACTCCAAGTCGGAGATGCAGATCCACTCCAAGTCACACACCGAGACCAAGCCCCACAAGTGCCCACATTGCTCCAAGACCTTCGCCA
ACAGCTCCTACCTGGCCCAGCACATCCGTATACACTCAGGGGCTAAGCCCTACAGTTGTAACTTCTGTGAGAAATCCTTCCGCCAGCTCT
CCCACCTTCAGCAGCACACCCGAATCCACACTGGTGATAGACCATACAAATGTGCACACCCAGGCTGTGAGAAAGCCTTCACACAACTCT
CCAATCTGCAGTCCCACAGACGGCAACACAACAAAGATAAACCCTTCAAGTGCCACAACTGTCATCGGGCGTACACGGATGCAGCCTCAC
TAGAGGTGCACCTGTCTACGCACACAGTGAAGCATGCCAAGGTGTACACCTGCACTATCTGCAGTCGGGCATACACATCACCTCCTCAGT
TCCAGATTTTGAGGAAGCTGTCCCAGGAACCTGTGGCCACAGCCATCCCGTCAGCTGTGACTCCCAGGCAGCTCACCCTGTTATCGTGGC
CAGAGAGGATGCCTGAGGAAGAGGGAAAGGAGTCAGCCTGTCTCTCCAAGCTGATTTGGAAAGCAGTGTGTGCATGCGTGTAAGTGTATG
TGTGGGTGTGTGGGTGTGTGTGTGTATGTGGGTGTGTGGGGGGATATGTGTGCATGTGTATGCATGTGTGGGTGTGTGTACGTGTGTGTG
TGCATGTGTGCTTGAGCACATGCATGCAGGGATCCTAGACTCGGTAGACTGGGCTCAACCCCTGAAGAAGGCTAAGAGACTGAAAGAGGA
TTAGCTGTAGGGCAGGGGGTTCTCTGTCAAGAGCTTTGGTTGGGGGAGGGCTGGGATCAGACAGAGAAAGGCTGGAAGCATCTGTGTACT
ATGAAAAAACCCGAGGGCACCTTGACAGGTGCTGGAAAAGAGAAGGCAACCGTTCATCCTATTTCTTTGCTTCCAGATGAAGAAACTGAG
GCCCATGGAGGAGTGACTTGTGCAAGGACACTCAGAAAGTGAGCAACAGAATTAGGATTTGGATTCTGCCCCTGGCCAGTGTTATTTTCA
TCAGCACCTGGCCTCTTGATAGAGAAGAAGCCATCCTATCTGACCAACTTCAGGCTAGTCTTAGATGAGCCCTAGGCTGCAGTCAGGGCC
CTCGGGCCACTCCAGATCTCCTTGATTCTGCCTTGATTCCATGTTTCCCTGAGGCTGTCTTGCCTCTCAGTGGGTGCCCCTGAAATGCCA
GGAACCCAGAACTGACTGGACAGTCATGGTCCACAGATCTCCTAGGGCAGGGAGCAGTCATGGCATTGGGCAGTGGAGAGAGGCTGCTTA
GAGCAACACTGAGGGAAAACAGTCCTAGTTGGGAACCAAGGGGTACTGGATTCCAGGGGTGGAGTCACCCAGTGACAAGGGACAGCAGTA
AGAGAGTCCGAAATGGGAGCTGATGGGGGGTACAGAATGGGGAGGGAGGGCTGGGGAGGGTCCTTCCAGCTGAGGAAGCAGCAGCCAGGG
CTGGCCCTTACCCACACGCTCAGACTTCATGGAGTCCCAGACATTGCAGTTGAAGTCGTCGTAGCCAGCGAATAGTAGGCGGCCACTGAG
GGAGAAGGCCACGGACGTGATGCCGCAGATGATGCTCTCGTGGGAGAAGCAGATCAGCTCCTGGTCTGCCCGCAGGTCAAACAAGCGGCA
GGAAGCGTCATCCGAGCCCGTGCAGATGGCCTCTCCATTGGGGAAGAACTGAGGGCACGGGTGGCAAGTGGGTCAGGGATCAGACCTGGG
CAGCCCACAGCCTCTCCCGCCCTCTGCCTCCCACCTGACAGCTCCAGGGCAAGCCGCTGCTCTCAGCCTCCCTGCCTGTCCCTCCCTTGG
TTTGGGGTGAGAAGCAGCCCTGCCAACACATACCACGTGCCAGTGACTTCCCTATGCCCCTCGCCCGCTCTGCACTATACAGCGCTGCAG
GCAGGCATCATTTCCACGTCGCAGGCAAGAGCACCAAGGCTTGCCTGCAGTGACCCGGCTAGAAGGGCGGACGGAGGTTGTCCCAGACTC
CCAGACTACACAAGTGGGCTGGATCAGGGTGTGTAAGAACAGGGTCCAGTACAAATGCAAGGCCTGGATCTCACGGCGAGCAAATGTCAG
ATAAGCTCAAACGGAGGGAGAGTCTACAGAAAACTGGTTTGTACTCTTCAAAAACGTCAATGACATAAAAGACAAAGGTGGGAAAACAGT
TCCAGTTTAAAGGTGGTGACGAAAAAGATATGGCGAGGAAAGGTAATGCACGTTTCTGGATTGGATCCTGGACAGAAAAAAACATGAGCT
ATTATGGACATTTTTGAGGCTATTGGTGAAATTTGAATATAGACTGTAGACTGTAGTATTGTGTCAATGTTGAGTTTCCTGATCTTAAGA
ATCATACAGTGATTATGCTACAGAAGGGCTTTGTTTCGGGAAGTACTTAAGGGGTAAAGAAACATGATGTCTGCAACCTACTTTCAAAAG
ACACAGAAAGAAAATGTATATCTACATCTAAGTGTTTTCCAAGGAGGAAGCAAGACAGCCCACAGAAACCCCTGTGGCCAGCCAGAGCTC

>101951_101951_1_ZNF384-CDCA3_ZNF384_chr12_6778197_ENST00000319770_CDCA3_chr12_6958828_ENST00000422785_length(amino acids)=519AA_BP=
MRVSRARSVRVSVWVCLAPEVRARALRLALFPLPRPFLVLPPSSAPSFPSKRRPSRALAQALAPPQPSPPESSGALERRRNKTAGGRERE
GRMEESHFNSNPYFWPSIPTVSGQIENTMFINKMKDQLLPEKGCGLAPPHYPTLLTVPASVSLPSGISMDTESKSDQLTPHSQASVTQNI
TVVPVPSTGLMTAGPGLVITSPSGSLVTTASSAQTFPISAPMIVSALPPGSQALQVVPDLSKKVASTLTEEGGGGGGGGGSVAPKPPRGR
KKKRMLESGLPEMNDPYVLSPEDDDDHQKDGKTYRCRMCSLTFYSKSEMQIHSKSHTETKPHKCPHCSKTFANSSYLAQHIRIHSGAKPY
SCNFCEKSFRQLSHLQQHTRIHTGDRPYKCAHPGCEKAFTQLSNLQSHRRQHNKDKPFKCHNCHRAYTDAASLEVHLSTHTVKHAKVYTC

--------------------------------------------------------------
>101951_101951_2_ZNF384-CDCA3_ZNF384_chr12_6778197_ENST00000355772_CDCA3_chr12_6958828_ENST00000422785_length(transcript)=3347nt_BP=1136nt
AGCTCTTCTCTGAGCCTGTTGGGGGGAGGGAGGGGGGCGTGGAGGAACTGGGGTTCGCGGGAGCACGAGCTGCAGCACCACTTCCGGAAA
GTTCAGGAGCCCTGGAAAGGAGAAGGAATAAGACGGCAGGAGGAAGAGAGAGAGAGGGTAGAATGGAAGAATCTCACTTCAATTCTAACC
CGTACTTCTGGCCTTCTATCCCCACAGTCTCAGGTCAGATCGAGAACACAATGTTCATCAACAAGATGAAGGATCAGCTGTTGCCAGAGA
AGGGCTGTGGTCTGGCCCCACCTCACTACCCCACCTTGCTGACAGTGCCTGCCTCAGTGTCCCTGCCCTCAGGCATCAGTATGGACACAG
AGTCCAAGTCAGACCAGCTGACCCCACACAGCCAAGCGTCCGTTACCCAGAATATCACGGTGGTCCCTGTGCCGTCTACAGGACTGATGA
CTGCTGCCCTGCAGGTTGTCCCTGACCTCTCCAAGAAGGTAGCATCGACCCTAACCGAGGAAGGAGGCGGAGGTGGTGGTGGAGGTGGCA
GTGTGGCTCCTAAGCCACCCCGGGGCCGGAAGAAGAAGCGGATGCTGGAATCAGGGCTGCCCGAGATGAATGACCCTTATGTCCTCTCCC
CTGAGGATGATGATGACCATCAGAAAGACGGCAAGACCTACAGGTGCCGGATGTGCTCACTGACATTCTACTCCAAGTCGGAGATGCAGA
TCCACTCCAAGTCACACACCGAGACCAAGCCCCACAAGTGCCCACATTGCTCCAAGACCTTCGCCAACAGCTCCTACCTGGCCCAGCACA
TCCGTATACACTCAGGGGCTAAGCCCTACAGTTGTAACTTCTGTGAGAAATCCTTCCGCCAGCTCTCCCACCTTCAGCAGCACACCCGAA
TCCACACTGGTGATAGACCATACAAATGTGCACACCCAGGCTGTGAGAAAGCCTTCACACAACTCTCCAATCTGCAGTCCCACAGACGGC
AACACAACAAAGATAAACCCTTCAAGTGCCACAACTGTCATCGGGCGTACACGGATGCAGCCTCACTAGAGGTGCACCTGTCTACGCACA
CAGTGAAGCATGCCAAGGTGTACACCTGCACTATCTGCAGTCGGGCATACACATCACCTCCTCAGTTCCAGATTTTGAGGAAGCTGTCCC
AGGAACCTGTGGCCACAGCCATCCCGTCAGCTGTGACTCCCAGGCAGCTCACCCTGTTATCGTGGCCAGAGAGGATGCCTGAGGAAGAGG
GAAAGGAGTCAGCCTGTCTCTCCAAGCTGATTTGGAAAGCAGTGTGTGCATGCGTGTAAGTGTATGTGTGGGTGTGTGGGTGTGTGTGTG
TATGTGGGTGTGTGGGGGGATATGTGTGCATGTGTATGCATGTGTGGGTGTGTGTACGTGTGTGTGTGCATGTGTGCTTGAGCACATGCA
TGCAGGGATCCTAGACTCGGTAGACTGGGCTCAACCCCTGAAGAAGGCTAAGAGACTGAAAGAGGATTAGCTGTAGGGCAGGGGGTTCTC
TGTCAAGAGCTTTGGTTGGGGGAGGGCTGGGATCAGACAGAGAAAGGCTGGAAGCATCTGTGTACTATGAAAAAACCCGAGGGCACCTTG
ACAGGTGCTGGAAAAGAGAAGGCAACCGTTCATCCTATTTCTTTGCTTCCAGATGAAGAAACTGAGGCCCATGGAGGAGTGACTTGTGCA
AGGACACTCAGAAAGTGAGCAACAGAATTAGGATTTGGATTCTGCCCCTGGCCAGTGTTATTTTCATCAGCACCTGGCCTCTTGATAGAG
AAGAAGCCATCCTATCTGACCAACTTCAGGCTAGTCTTAGATGAGCCCTAGGCTGCAGTCAGGGCCCTCGGGCCACTCCAGATCTCCTTG
ATTCTGCCTTGATTCCATGTTTCCCTGAGGCTGTCTTGCCTCTCAGTGGGTGCCCCTGAAATGCCAGGAACCCAGAACTGACTGGACAGT
CATGGTCCACAGATCTCCTAGGGCAGGGAGCAGTCATGGCATTGGGCAGTGGAGAGAGGCTGCTTAGAGCAACACTGAGGGAAAACAGTC
CTAGTTGGGAACCAAGGGGTACTGGATTCCAGGGGTGGAGTCACCCAGTGACAAGGGACAGCAGTAAGAGAGTCCGAAATGGGAGCTGAT
GGGGGGTACAGAATGGGGAGGGAGGGCTGGGGAGGGTCCTTCCAGCTGAGGAAGCAGCAGCCAGGGCTGGCCCTTACCCACACGCTCAGA
CTTCATGGAGTCCCAGACATTGCAGTTGAAGTCGTCGTAGCCAGCGAATAGTAGGCGGCCACTGAGGGAGAAGGCCACGGACGTGATGCC
GCAGATGATGCTCTCGTGGGAGAAGCAGATCAGCTCCTGGTCTGCCCGCAGGTCAAACAAGCGGCAGGAAGCGTCATCCGAGCCCGTGCA
GATGGCCTCTCCATTGGGGAAGAACTGAGGGCACGGGTGGCAAGTGGGTCAGGGATCAGACCTGGGCAGCCCACAGCCTCTCCCGCCCTC
TGCCTCCCACCTGACAGCTCCAGGGCAAGCCGCTGCTCTCAGCCTCCCTGCCTGTCCCTCCCTTGGTTTGGGGTGAGAAGCAGCCCTGCC
AACACATACCACGTGCCAGTGACTTCCCTATGCCCCTCGCCCGCTCTGCACTATACAGCGCTGCAGGCAGGCATCATTTCCACGTCGCAG
GCAAGAGCACCAAGGCTTGCCTGCAGTGACCCGGCTAGAAGGGCGGACGGAGGTTGTCCCAGACTCCCAGACTACACAAGTGGGCTGGAT
CAGGGTGTGTAAGAACAGGGTCCAGTACAAATGCAAGGCCTGGATCTCACGGCGAGCAAATGTCAGATAAGCTCAAACGGAGGGAGAGTC
TACAGAAAACTGGTTTGTACTCTTCAAAAACGTCAATGACATAAAAGACAAAGGTGGGAAAACAGTTCCAGTTTAAAGGTGGTGACGAAA
AAGATATGGCGAGGAAAGGTAATGCACGTTTCTGGATTGGATCCTGGACAGAAAAAAACATGAGCTATTATGGACATTTTTGAGGCTATT
GGTGAAATTTGAATATAGACTGTAGACTGTAGTATTGTGTCAATGTTGAGTTTCCTGATCTTAAGAATCATACAGTGATTATGCTACAGA
AGGGCTTTGTTTCGGGAAGTACTTAAGGGGTAAAGAAACATGATGTCTGCAACCTACTTTCAAAAGACACAGAAAGAAAATGTATATCTA
CATCTAAGTGTTTTCCAAGGAGGAAGCAAGACAGCCCACAGAAACCCCTGTGGCCAGCCAGAGCTCCGACAAGCCCTCAAGGGACCCTGA

>101951_101951_2_ZNF384-CDCA3_ZNF384_chr12_6778197_ENST00000355772_CDCA3_chr12_6958828_ENST00000422785_length(amino acids)=423AA_BP=
MGFAGARAAAPLPESSGALERRRNKTAGGREREGRMEESHFNSNPYFWPSIPTVSGQIENTMFINKMKDQLLPEKGCGLAPPHYPTLLTV
PASVSLPSGISMDTESKSDQLTPHSQASVTQNITVVPVPSTGLMTAALQVVPDLSKKVASTLTEEGGGGGGGGGSVAPKPPRGRKKKRML
ESGLPEMNDPYVLSPEDDDDHQKDGKTYRCRMCSLTFYSKSEMQIHSKSHTETKPHKCPHCSKTFANSSYLAQHIRIHSGAKPYSCNFCE
KSFRQLSHLQQHTRIHTGDRPYKCAHPGCEKAFTQLSNLQSHRRQHNKDKPFKCHNCHRAYTDAASLEVHLSTHTVKHAKVYTCTICSRA

--------------------------------------------------------------
>101951_101951_3_ZNF384-CDCA3_ZNF384_chr12_6778197_ENST00000361959_CDCA3_chr12_6958828_ENST00000422785_length(transcript)=3803nt_BP=1592nt
CGCGTTCCGTGCGTGTGAGTGTGTGGGTCTGTCTCGCTCCAGAAGTGCGTGCCCGCGCGCTGCGCCTTGCGCTTTTTCCCCTCCCTCGCC
CCTTCCTGGTCCTCCCACCCTCCTCGGCTCCCTCCTTTCCCAGCAAACGCCGCCCCTCCCGCGCCCTGGCTCAGGCTCTGGCGCCGCCGC
AGCCGTCGCCGCCCGAAAGTTCAGGAGCCCTGGAAAGGAGAAGGAATAAGACGGCAGGAGGAAGAGAGAGAGAGGGTAGAATGGAAGAAT
CTCACTTCAATTCTAACCCGTACTTCTGGCCTTCTATCCCCACAGTCTCAGGTCAGATCGAGAACACAATGTTCATCAACAAGATGAAGG
ATCAGCTGTTGCCAGAGAAGGGCTGTGGTCTGGCCCCACCTCACTACCCCACCTTGCTGACAGTGCCTGCCTCAGTGTCCCTGCCCTCAG
GCATCAGTATGGACACAGAGTCCAAGTCAGACCAGCTGACCCCACACAGCCAAGCGTCCGTTACCCAGAATATCACGGTGGTCCCTGTGC
CGTCTACAGGACTGATGACTGCTGGAGTCTCCTGTTCTCAGAGGTGGAGAAGAGAAGGGAGTCAATCAAGGGGTCCGGGTTTGGTAATCA
CGTCCCCCTCAGGCTCTCTTGTGACCACAGCATCATCAGCTCAGACCTTCCCCATTTCGGCTCCCATGATTGTCTCAGCTCTTCCCCCTG
GCTCACAAGCCCTGCAGGTTGTCCCTGACCTCTCCAAGAAGGTAGCATCGACCCTAACCGAGGAAGGAGGCGGAGGTGGTGGTGGAGGTG
GCAGTGTGGCTCCTAAGCCACCCCGGGGCCGGAAGAAGAAGCGGATGCTGGAATCAGGGCTGCCCGAGATGAATGACCCTTATGTCCTCT
CCCCTGAGGATGATGATGACCATCAGAAAGACGGCAAGACCTACAGGTGCCGGATGTGCTCACTGACATTCTACTCCAAGTCGGAGATGC
AGATCCACTCCAAGTCACACACCGAGACCAAGCCCCACAAGTGCCCACATTGCTCCAAGACCTTCGCCAACAGCTCCTACCTGGCCCAGC
ACATCCGTATACACTCAGGGGCTAAGCCCTACAGTTGTAACTTCTGTGAGAAATCCTTCCGCCAGCTCTCCCACCTTCAGCAGCACACCC
GGATCCACTCCAAGATGCACACGGAGACCATCAAGCCCCACAAGTGCCCGCACTGCTCCAAGACCTTCGCCAACACCTCCTACCTGGCCC
AGCACCTCCGTATCCACTCGGGGGCCAAGCCCTACAACTGTTCCTACTGCCAGAAGGCCTTCCGCCAGCTCTCCCACCTCCAGCAGCACA
CACGAATCCACACTGGTGATAGACCATACAAATGTGCACACCCAGGCTGTGAGAAAGCCTTCACACAACTCTCCAATCTGCAGTCCCACA
GACGGCAACACAACAAAGATAAACCCTTCAAGTGCCACAACTGTCATCGGGCGTACACGGATGCAGCCTCACTAGAGGTGCACCTGTCTA
CGCACACAGTGAAGCATGCCAAGGTGTACACCTGCACTATCTGCAGTCGGGCATACACATCACCTCCTCAGTTCCAGATTTTGAGGAAGC
TGTCCCAGGAACCTGTGGCCACAGCCATCCCGTCAGCTGTGACTCCCAGGCAGCTCACCCTGTTATCGTGGCCAGAGAGGATGCCTGAGG
AAGAGGGAAAGGAGTCAGCCTGTCTCTCCAAGCTGATTTGGAAAGCAGTGTGTGCATGCGTGTAAGTGTATGTGTGGGTGTGTGGGTGTG
TGTGTGTATGTGGGTGTGTGGGGGGATATGTGTGCATGTGTATGCATGTGTGGGTGTGTGTACGTGTGTGTGTGCATGTGTGCTTGAGCA
CATGCATGCAGGGATCCTAGACTCGGTAGACTGGGCTCAACCCCTGAAGAAGGCTAAGAGACTGAAAGAGGATTAGCTGTAGGGCAGGGG
GTTCTCTGTCAAGAGCTTTGGTTGGGGGAGGGCTGGGATCAGACAGAGAAAGGCTGGAAGCATCTGTGTACTATGAAAAAACCCGAGGGC
ACCTTGACAGGTGCTGGAAAAGAGAAGGCAACCGTTCATCCTATTTCTTTGCTTCCAGATGAAGAAACTGAGGCCCATGGAGGAGTGACT
TGTGCAAGGACACTCAGAAAGTGAGCAACAGAATTAGGATTTGGATTCTGCCCCTGGCCAGTGTTATTTTCATCAGCACCTGGCCTCTTG
ATAGAGAAGAAGCCATCCTATCTGACCAACTTCAGGCTAGTCTTAGATGAGCCCTAGGCTGCAGTCAGGGCCCTCGGGCCACTCCAGATC
TCCTTGATTCTGCCTTGATTCCATGTTTCCCTGAGGCTGTCTTGCCTCTCAGTGGGTGCCCCTGAAATGCCAGGAACCCAGAACTGACTG
GACAGTCATGGTCCACAGATCTCCTAGGGCAGGGAGCAGTCATGGCATTGGGCAGTGGAGAGAGGCTGCTTAGAGCAACACTGAGGGAAA
ACAGTCCTAGTTGGGAACCAAGGGGTACTGGATTCCAGGGGTGGAGTCACCCAGTGACAAGGGACAGCAGTAAGAGAGTCCGAAATGGGA
GCTGATGGGGGGTACAGAATGGGGAGGGAGGGCTGGGGAGGGTCCTTCCAGCTGAGGAAGCAGCAGCCAGGGCTGGCCCTTACCCACACG
CTCAGACTTCATGGAGTCCCAGACATTGCAGTTGAAGTCGTCGTAGCCAGCGAATAGTAGGCGGCCACTGAGGGAGAAGGCCACGGACGT
GATGCCGCAGATGATGCTCTCGTGGGAGAAGCAGATCAGCTCCTGGTCTGCCCGCAGGTCAAACAAGCGGCAGGAAGCGTCATCCGAGCC
CGTGCAGATGGCCTCTCCATTGGGGAAGAACTGAGGGCACGGGTGGCAAGTGGGTCAGGGATCAGACCTGGGCAGCCCACAGCCTCTCCC
GCCCTCTGCCTCCCACCTGACAGCTCCAGGGCAAGCCGCTGCTCTCAGCCTCCCTGCCTGTCCCTCCCTTGGTTTGGGGTGAGAAGCAGC
CCTGCCAACACATACCACGTGCCAGTGACTTCCCTATGCCCCTCGCCCGCTCTGCACTATACAGCGCTGCAGGCAGGCATCATTTCCACG
TCGCAGGCAAGAGCACCAAGGCTTGCCTGCAGTGACCCGGCTAGAAGGGCGGACGGAGGTTGTCCCAGACTCCCAGACTACACAAGTGGG
CTGGATCAGGGTGTGTAAGAACAGGGTCCAGTACAAATGCAAGGCCTGGATCTCACGGCGAGCAAATGTCAGATAAGCTCAAACGGAGGG
AGAGTCTACAGAAAACTGGTTTGTACTCTTCAAAAACGTCAATGACATAAAAGACAAAGGTGGGAAAACAGTTCCAGTTTAAAGGTGGTG
ACGAAAAAGATATGGCGAGGAAAGGTAATGCACGTTTCTGGATTGGATCCTGGACAGAAAAAAACATGAGCTATTATGGACATTTTTGAG
GCTATTGGTGAAATTTGAATATAGACTGTAGACTGTAGTATTGTGTCAATGTTGAGTTTCCTGATCTTAAGAATCATACAGTGATTATGC
TACAGAAGGGCTTTGTTTCGGGAAGTACTTAAGGGGTAAAGAAACATGATGTCTGCAACCTACTTTCAAAAGACACAGAAAGAAAATGTA
TATCTACATCTAAGTGTTTTCCAAGGAGGAAGCAAGACAGCCCACAGAAACCCCTGTGGCCAGCCAGAGCTCCGACAAGCCCTCAAGGGA

>101951_101951_3_ZNF384-CDCA3_ZNF384_chr12_6778197_ENST00000361959_CDCA3_chr12_6958828_ENST00000422785_length(amino acids)=571AA_BP=
MRLALFPLPRPFLVLPPSSAPSFPSKRRPSRALAQALAPPQPSPPESSGALERRRNKTAGGREREGRMEESHFNSNPYFWPSIPTVSGQI
ENTMFINKMKDQLLPEKGCGLAPPHYPTLLTVPASVSLPSGISMDTESKSDQLTPHSQASVTQNITVVPVPSTGLMTAGVSCSQRWRREG
SQSRGPGLVITSPSGSLVTTASSAQTFPISAPMIVSALPPGSQALQVVPDLSKKVASTLTEEGGGGGGGGGSVAPKPPRGRKKKRMLESG
LPEMNDPYVLSPEDDDDHQKDGKTYRCRMCSLTFYSKSEMQIHSKSHTETKPHKCPHCSKTFANSSYLAQHIRIHSGAKPYSCNFCEKSF
RQLSHLQQHTRIHSKMHTETIKPHKCPHCSKTFANTSYLAQHLRIHSGAKPYNCSYCQKAFRQLSHLQQHTRIHTGDRPYKCAHPGCEKA
FTQLSNLQSHRRQHNKDKPFKCHNCHRAYTDAASLEVHLSTHTVKHAKVYTCTICSRAYTSPPQFQILRKLSQEPVATAIPSAVTPRQLT

--------------------------------------------------------------
>101951_101951_4_ZNF384-CDCA3_ZNF384_chr12_6778197_ENST00000396799_CDCA3_chr12_6958828_ENST00000422785_length(transcript)=3838nt_BP=1627nt
GCTATTTCCCTCCCTCCCCCCTTTTCGTTTCCGGCGCTCCCGCCTTCTCTCCGCAGAGCTCTTCTCTGAGCCTGTTGGGGGGAGGGAGGG
GGGCGTGGAGGAACTGGGGTTCGCGGGAGCACGAGCTGCAGCACCACTTCCGGGTGAGTGCAAGGGGAGGGCAGCAAGGAGGGGGGGCCA
CCCACTACCTCGCGCCCCCGCCCTGCGGGTGTCTCGCGCGCGTTCCGTGCGTGTGAGTGTGTGGGTCTGTCTCGCTCCAGAAGTGCGTGC
CCGCGCGCTGCGCCTTGCGCTTTTTCCCCTCCCTCGCCCCTTCCTGGTCCTCCCACCCTCCTCGGCTCCCTCCTTTCCCAGCAAACGCCG
CCCCTCCCGCGCCCTGGCTCAGGCTCTGGCGCCGCCGCAGCCGTCGCCGCCCGAAAGTTCAGGAGCCCTGGAAAGGAGAAGGAATAAGAC
GGCAGGAGGAAGAGAGAGAGAGGGTAGAATGGAAGAATCTCACTTCAATTCTAACCCGTACTTCTGGCCTTCTATCCCCACAGTCTCAGG
TCAGATCGAGAACACAATGTTCATCAACAAGATGAAGGATCAGCTGTTGCCAGAGAAGGGCTGTGGTCTGGCCCCACCTCACTACCCCAC
CTTGCTGACAGTGCCTGCCTCAGTGTCCCTGCCCTCAGGCATCAGTATGGACACAGAGTCCAAGTCAGACCAGCTGACCCCACACAGCCA
AGCGTCCGTTACCCAGAATATCACGGTGGTCCCTGTGCCGTCTACAGGACTGATGACTGCTGGAGTCTCCTGTTCTCAGAGGTGGAGAAG
AGAAGGGAGTCAATCAAGGGGTCCGGGTTTGGTAATCACGTCCCCCTCAGGCTCTCTTGTGACCACAGCATCATCAGCTCAGACCTTCCC
CATTTCGGCTCCCATGATTGTCTCAGCTCTTCCCCCTGGCTCACAAGCCCTGCAGGTTGTCCCTGACCTCTCCAAGAAGGTAGCATCGAC
CCTAACCGAGGAAGGAGGCGGAGGTGGTGGTGGAGGTGGCAGTGTGGCTCCTAAGCCACCCCGGGGCCGGAAGAAGAAGCGGATGCTGGA
ATCAGGGCTGCCCGAGATGAATGACCCTTATGTCCTCTCCCCTGAGGATGATGATGACCATCAGAAAGACGGCAAGACCTACAGGTGCCG
GATGTGCTCACTGACATTCTACTCCAAGTCGGAGATGCAGATCCACTCCAAGTCACACACCGAGACCAAGCCCCACAAGTGCCCACATTG
CTCCAAGACCTTCGCCAACAGCTCCTACCTGGCCCAGCACATCCGTATACACTCAGGGGCTAAGCCCTACAGTTGTAACTTCTGTGAGAA
ATCCTTCCGCCAGCTCTCCCACCTTCAGCAGCACACCCGAATCCACACTGGTGATAGACCATACAAATGTGCACACCCAGGCTGTGAGAA
AGCCTTCACACAACTCTCCAATCTGCAGTCCCACAGACGGCAACACAACAAAGATAAACCCTTCAAGTGCCACAACTGTCATCGGGCGTA
CACGGATGCAGCCTCACTAGAGGTGCACCTGTCTACGCACACAGTGAAGCATGCCAAGGTGTACACCTGCACTATCTGCAGTCGGGCATA
CACATCACCTCCTCAGTTCCAGATTTTGAGGAAGCTGTCCCAGGAACCTGTGGCCACAGCCATCCCGTCAGCTGTGACTCCCAGGCAGCT
CACCCTGTTATCGTGGCCAGAGAGGATGCCTGAGGAAGAGGGAAAGGAGTCAGCCTGTCTCTCCAAGCTGATTTGGAAAGCAGTGTGTGC
ATGCGTGTAAGTGTATGTGTGGGTGTGTGGGTGTGTGTGTGTATGTGGGTGTGTGGGGGGATATGTGTGCATGTGTATGCATGTGTGGGT
GTGTGTACGTGTGTGTGTGCATGTGTGCTTGAGCACATGCATGCAGGGATCCTAGACTCGGTAGACTGGGCTCAACCCCTGAAGAAGGCT
AAGAGACTGAAAGAGGATTAGCTGTAGGGCAGGGGGTTCTCTGTCAAGAGCTTTGGTTGGGGGAGGGCTGGGATCAGACAGAGAAAGGCT
GGAAGCATCTGTGTACTATGAAAAAACCCGAGGGCACCTTGACAGGTGCTGGAAAAGAGAAGGCAACCGTTCATCCTATTTCTTTGCTTC
CAGATGAAGAAACTGAGGCCCATGGAGGAGTGACTTGTGCAAGGACACTCAGAAAGTGAGCAACAGAATTAGGATTTGGATTCTGCCCCT
GGCCAGTGTTATTTTCATCAGCACCTGGCCTCTTGATAGAGAAGAAGCCATCCTATCTGACCAACTTCAGGCTAGTCTTAGATGAGCCCT
AGGCTGCAGTCAGGGCCCTCGGGCCACTCCAGATCTCCTTGATTCTGCCTTGATTCCATGTTTCCCTGAGGCTGTCTTGCCTCTCAGTGG
GTGCCCCTGAAATGCCAGGAACCCAGAACTGACTGGACAGTCATGGTCCACAGATCTCCTAGGGCAGGGAGCAGTCATGGCATTGGGCAG
TGGAGAGAGGCTGCTTAGAGCAACACTGAGGGAAAACAGTCCTAGTTGGGAACCAAGGGGTACTGGATTCCAGGGGTGGAGTCACCCAGT
GACAAGGGACAGCAGTAAGAGAGTCCGAAATGGGAGCTGATGGGGGGTACAGAATGGGGAGGGAGGGCTGGGGAGGGTCCTTCCAGCTGA
GGAAGCAGCAGCCAGGGCTGGCCCTTACCCACACGCTCAGACTTCATGGAGTCCCAGACATTGCAGTTGAAGTCGTCGTAGCCAGCGAAT
AGTAGGCGGCCACTGAGGGAGAAGGCCACGGACGTGATGCCGCAGATGATGCTCTCGTGGGAGAAGCAGATCAGCTCCTGGTCTGCCCGC
AGGTCAAACAAGCGGCAGGAAGCGTCATCCGAGCCCGTGCAGATGGCCTCTCCATTGGGGAAGAACTGAGGGCACGGGTGGCAAGTGGGT
CAGGGATCAGACCTGGGCAGCCCACAGCCTCTCCCGCCCTCTGCCTCCCACCTGACAGCTCCAGGGCAAGCCGCTGCTCTCAGCCTCCCT
GCCTGTCCCTCCCTTGGTTTGGGGTGAGAAGCAGCCCTGCCAACACATACCACGTGCCAGTGACTTCCCTATGCCCCTCGCCCGCTCTGC
ACTATACAGCGCTGCAGGCAGGCATCATTTCCACGTCGCAGGCAAGAGCACCAAGGCTTGCCTGCAGTGACCCGGCTAGAAGGGCGGACG
GAGGTTGTCCCAGACTCCCAGACTACACAAGTGGGCTGGATCAGGGTGTGTAAGAACAGGGTCCAGTACAAATGCAAGGCCTGGATCTCA
CGGCGAGCAAATGTCAGATAAGCTCAAACGGAGGGAGAGTCTACAGAAAACTGGTTTGTACTCTTCAAAAACGTCAATGACATAAAAGAC
AAAGGTGGGAAAACAGTTCCAGTTTAAAGGTGGTGACGAAAAAGATATGGCGAGGAAAGGTAATGCACGTTTCTGGATTGGATCCTGGAC
AGAAAAAAACATGAGCTATTATGGACATTTTTGAGGCTATTGGTGAAATTTGAATATAGACTGTAGACTGTAGTATTGTGTCAATGTTGA
GTTTCCTGATCTTAAGAATCATACAGTGATTATGCTACAGAAGGGCTTTGTTTCGGGAAGTACTTAAGGGGTAAAGAAACATGATGTCTG
CAACCTACTTTCAAAAGACACAGAAAGAAAATGTATATCTACATCTAAGTGTTTTCCAAGGAGGAAGCAAGACAGCCCACAGAAACCCCT

>101951_101951_4_ZNF384-CDCA3_ZNF384_chr12_6778197_ENST00000396799_CDCA3_chr12_6958828_ENST00000422785_length(amino acids)=568AA_BP=
MGFAGARAAAPLPGECKGRAARRGGHPLPRAPALRVSRARSVRVSVWVCLAPEVRARALRLALFPLPRPFLVLPPSSAPSFPSKRRPSRA
LAQALAPPQPSPPESSGALERRRNKTAGGREREGRMEESHFNSNPYFWPSIPTVSGQIENTMFINKMKDQLLPEKGCGLAPPHYPTLLTV
PASVSLPSGISMDTESKSDQLTPHSQASVTQNITVVPVPSTGLMTAGVSCSQRWRREGSQSRGPGLVITSPSGSLVTTASSAQTFPISAP
MIVSALPPGSQALQVVPDLSKKVASTLTEEGGGGGGGGGSVAPKPPRGRKKKRMLESGLPEMNDPYVLSPEDDDDHQKDGKTYRCRMCSL
TFYSKSEMQIHSKSHTETKPHKCPHCSKTFANSSYLAQHIRIHSGAKPYSCNFCEKSFRQLSHLQQHTRIHTGDRPYKCAHPGCEKAFTQ
LSNLQSHRRQHNKDKPFKCHNCHRAYTDAASLEVHLSTHTVKHAKVYTCTICSRAYTSPPQFQILRKLSQEPVATAIPSAVTPRQLTLLS

--------------------------------------------------------------
>101951_101951_5_ZNF384-CDCA3_ZNF384_chr12_6778197_ENST00000396801_CDCA3_chr12_6958828_ENST00000422785_length(transcript)=3751nt_BP=1540nt
GCTATTTCCCTCCCTCCCCCCTTTTCGTTTCCGGCGCTCCCGCCTTCTCTCCGCAGAGCTCTTCTCTGAGCCTGTTGGGGGGAGGGAGGG
GGGCGTGGAGGAACTGGGGTTCGCGGGAGCACGAGCTGCAGCACCACTTCCGGAAAGTTCAGGAGCCCTGGAAAGGAGAAGGAATAAGAC
GGCAGGAGGAAGAGAGAGAGAGGGTAGAATGGAAGAATCTCACTTCAATTCTAACCCGTACTTCTGGCCTTCTATCCCCACAGTCTCAGG
TCAGATCGAGAACACAATGTTCATCAACAAGATGAAGGATCAGCTGTTGCCAGAGAAGGGCTGTGGTCTGGCCCCACCTCACTACCCCAC
CTTGCTGACAGTGCCTGCCTCAGTGTCCCTGCCCTCAGGCATCAGTATGGACACAGAGTCCAAGTCAGACCAGCTGACCCCACACAGCCA
AGCGTCCGTTACCCAGAATATCACGGTGGTCCCTGTGCCGTCTACAGGACTGATGACTGCTGGAGTCTCCTGTTCTCAGAGGTGGAGAAG
AGAAGGGAGTCAATCAAGGGGTCCGGGTTTGGTAATCACGTCCCCCTCAGGCTCTCTTGTGACCACAGCATCATCAGCTCAGACCTTCCC
CATTTCGGCTCCCATGATTGTCTCAGCTCTTCCCCCTGGCTCACAAGCCCTGCAGGTTGTCCCTGACCTCTCCAAGAAGGTAGCATCGAC
CCTAACCGAGGAAGGAGGCGGAGGTGGTGGTGGAGGTGGCAGTGTGGCTCCTAAGCCACCCCGGGGCCGGAAGAAGAAGCGGATGCTGGA
ATCAGGGCTGCCCGAGATGAATGACCCTTATGTCCTCTCCCCTGAGGATGATGATGACCATCAGAAAGACGGCAAGACCTACAGGTGCCG
GATGTGCTCACTGACATTCTACTCCAAGTCGGAGATGCAGATCCACTCCAAGTCACACACCGAGACCAAGCCCCACAAGTGCCCACATTG
CTCCAAGACCTTCGCCAACAGCTCCTACCTGGCCCAGCACATCCGTATACACTCAGGGGCTAAGCCCTACAGTTGTAACTTCTGTGAGAA
ATCCTTCCGCCAGCTCTCCCACCTTCAGCAGCACACCCGGATCCACTCCAAGATGCACACGGAGACCATCAAGCCCCACAAGTGCCCGCA
CTGCTCCAAGACCTTCGCCAACACCTCCTACCTGGCCCAGCACCTCCGTATCCACTCGGGGGCCAAGCCCTACAACTGTTCCTACTGCCA
GAAGGCCTTCCGCCAGCTCTCCCACCTCCAGCAGCACACACGAATCCACACTGGTGATAGACCATACAAATGTGCACACCCAGGCTGTGA
GAAAGCCTTCACACAACTCTCCAATCTGCAGTCCCACAGACGGCAACACAACAAAGATAAACCCTTCAAGTGCCACAACTGTCATCGGGC
GTACACGGATGCAGCCTCACTAGAGGTGCACCTGTCTACGCACACAGTGAAGCATGCCAAGGTGTACACCTGCACTATCTGCAGTCGGGC
ATACACATCACCTCCTCAGTTCCAGATTTTGAGGAAGCTGTCCCAGGAACCTGTGGCCACAGCCATCCCGTCAGCTGTGACTCCCAGGCA
GCTCACCCTGTTATCGTGGCCAGAGAGGATGCCTGAGGAAGAGGGAAAGGAGTCAGCCTGTCTCTCCAAGCTGATTTGGAAAGCAGTGTG
TGCATGCGTGTAAGTGTATGTGTGGGTGTGTGGGTGTGTGTGTGTATGTGGGTGTGTGGGGGGATATGTGTGCATGTGTATGCATGTGTG
GGTGTGTGTACGTGTGTGTGTGCATGTGTGCTTGAGCACATGCATGCAGGGATCCTAGACTCGGTAGACTGGGCTCAACCCCTGAAGAAG
GCTAAGAGACTGAAAGAGGATTAGCTGTAGGGCAGGGGGTTCTCTGTCAAGAGCTTTGGTTGGGGGAGGGCTGGGATCAGACAGAGAAAG
GCTGGAAGCATCTGTGTACTATGAAAAAACCCGAGGGCACCTTGACAGGTGCTGGAAAAGAGAAGGCAACCGTTCATCCTATTTCTTTGC
TTCCAGATGAAGAAACTGAGGCCCATGGAGGAGTGACTTGTGCAAGGACACTCAGAAAGTGAGCAACAGAATTAGGATTTGGATTCTGCC
CCTGGCCAGTGTTATTTTCATCAGCACCTGGCCTCTTGATAGAGAAGAAGCCATCCTATCTGACCAACTTCAGGCTAGTCTTAGATGAGC
CCTAGGCTGCAGTCAGGGCCCTCGGGCCACTCCAGATCTCCTTGATTCTGCCTTGATTCCATGTTTCCCTGAGGCTGTCTTGCCTCTCAG
TGGGTGCCCCTGAAATGCCAGGAACCCAGAACTGACTGGACAGTCATGGTCCACAGATCTCCTAGGGCAGGGAGCAGTCATGGCATTGGG
CAGTGGAGAGAGGCTGCTTAGAGCAACACTGAGGGAAAACAGTCCTAGTTGGGAACCAAGGGGTACTGGATTCCAGGGGTGGAGTCACCC
AGTGACAAGGGACAGCAGTAAGAGAGTCCGAAATGGGAGCTGATGGGGGGTACAGAATGGGGAGGGAGGGCTGGGGAGGGTCCTTCCAGC
TGAGGAAGCAGCAGCCAGGGCTGGCCCTTACCCACACGCTCAGACTTCATGGAGTCCCAGACATTGCAGTTGAAGTCGTCGTAGCCAGCG
AATAGTAGGCGGCCACTGAGGGAGAAGGCCACGGACGTGATGCCGCAGATGATGCTCTCGTGGGAGAAGCAGATCAGCTCCTGGTCTGCC
CGCAGGTCAAACAAGCGGCAGGAAGCGTCATCCGAGCCCGTGCAGATGGCCTCTCCATTGGGGAAGAACTGAGGGCACGGGTGGCAAGTG
GGTCAGGGATCAGACCTGGGCAGCCCACAGCCTCTCCCGCCCTCTGCCTCCCACCTGACAGCTCCAGGGCAAGCCGCTGCTCTCAGCCTC
CCTGCCTGTCCCTCCCTTGGTTTGGGGTGAGAAGCAGCCCTGCCAACACATACCACGTGCCAGTGACTTCCCTATGCCCCTCGCCCGCTC
TGCACTATACAGCGCTGCAGGCAGGCATCATTTCCACGTCGCAGGCAAGAGCACCAAGGCTTGCCTGCAGTGACCCGGCTAGAAGGGCGG
ACGGAGGTTGTCCCAGACTCCCAGACTACACAAGTGGGCTGGATCAGGGTGTGTAAGAACAGGGTCCAGTACAAATGCAAGGCCTGGATC
TCACGGCGAGCAAATGTCAGATAAGCTCAAACGGAGGGAGAGTCTACAGAAAACTGGTTTGTACTCTTCAAAAACGTCAATGACATAAAA
GACAAAGGTGGGAAAACAGTTCCAGTTTAAAGGTGGTGACGAAAAAGATATGGCGAGGAAAGGTAATGCACGTTTCTGGATTGGATCCTG
GACAGAAAAAAACATGAGCTATTATGGACATTTTTGAGGCTATTGGTGAAATTTGAATATAGACTGTAGACTGTAGTATTGTGTCAATGT
TGAGTTTCCTGATCTTAAGAATCATACAGTGATTATGCTACAGAAGGGCTTTGTTTCGGGAAGTACTTAAGGGGTAAAGAAACATGATGT
CTGCAACCTACTTTCAAAAGACACAGAAAGAAAATGTATATCTACATCTAAGTGTTTTCCAAGGAGGAAGCAAGACAGCCCACAGAAACC

>101951_101951_5_ZNF384-CDCA3_ZNF384_chr12_6778197_ENST00000396801_CDCA3_chr12_6958828_ENST00000422785_length(amino acids)=539AA_BP=
MGFAGARAAAPLPESSGALERRRNKTAGGREREGRMEESHFNSNPYFWPSIPTVSGQIENTMFINKMKDQLLPEKGCGLAPPHYPTLLTV
PASVSLPSGISMDTESKSDQLTPHSQASVTQNITVVPVPSTGLMTAGVSCSQRWRREGSQSRGPGLVITSPSGSLVTTASSAQTFPISAP
MIVSALPPGSQALQVVPDLSKKVASTLTEEGGGGGGGGGSVAPKPPRGRKKKRMLESGLPEMNDPYVLSPEDDDDHQKDGKTYRCRMCSL
TFYSKSEMQIHSKSHTETKPHKCPHCSKTFANSSYLAQHIRIHSGAKPYSCNFCEKSFRQLSHLQQHTRIHSKMHTETIKPHKCPHCSKT
FANTSYLAQHLRIHSGAKPYNCSYCQKAFRQLSHLQQHTRIHTGDRPYKCAHPGCEKAFTQLSNLQSHRRQHNKDKPFKCHNCHRAYTDA

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Fusion Gene PPI Analysis for ZNF384-CDCA3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF384-CDCA3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF384-CDCA3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource