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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF385B-SCG5 (FusionGDB2 ID:101964)

Fusion Gene Summary for ZNF385B-SCG5

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF385B-SCG5
Fusion gene ID: 101964
HgeneTgene
Gene symbol

ZNF385B

SCG5

Gene ID

151126

6447

Gene namezinc finger protein 385Bsecretogranin V
SynonymsZNF5337B2|P7B2|SGNE1|SgV
Cytomap

2q31.2-q31.3

15q13.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 385Bzinc finger protein 533neuroendocrine protein 7B2pituitary polypeptideprohormone convertase chaperonesecretogranin-5secretory granule endocrine protein Isecretory granule, neuroendocrine protein 1 (7B2 protein)
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000410066, ENST00000336917, 
ENST00000409343, ENST00000409692, 
ENST00000466398, 		ENST00000498069, 
ENST00000300175, ENST00000413748, 
ENST00000494364, ENST00000497208, 
Fusion gene scores* DoF score6 X 6 X 4=1445 X 3 X 5=75
# samples 75
** MAII scorelog2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF385B [Title/Abstract] AND SCG5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF385B(180634230)-SCG5(32971967), # samples:2
ZNF385B(180634230)-SCG5(32935787), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZNF385B

GO:0072332

intrinsic apoptotic signaling pathway by p53 class mediator

22945289


check buttonFusion gene breakpoints across ZNF385B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SCG5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-EW-A1PB-01AZNF385Bchr2

180634230

-SCG5chr15

32935787

+
ChimerDB4BRCATCGA-EW-A1PB-01AZNF385Bchr2

180634230

-SCG5chr15

32971967

+


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Fusion Gene ORF analysis for ZNF385B-SCG5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000410066ENST00000498069ZNF385Bchr2

180634230

-SCG5chr15

32971967

+
5CDS-5UTRENST00000410066ENST00000300175ZNF385Bchr2

180634230

-SCG5chr15

32935787

+
5CDS-5UTRENST00000410066ENST00000413748ZNF385Bchr2

180634230

-SCG5chr15

32935787

+
5CDS-5UTRENST00000410066ENST00000494364ZNF385Bchr2

180634230

-SCG5chr15

32935787

+
5CDS-5UTRENST00000410066ENST00000497208ZNF385Bchr2

180634230

-SCG5chr15

32935787

+
5CDS-intronENST00000410066ENST00000498069ZNF385Bchr2

180634230

-SCG5chr15

32935787

+
In-frameENST00000410066ENST00000300175ZNF385Bchr2

180634230

-SCG5chr15

32971967

+
In-frameENST00000410066ENST00000413748ZNF385Bchr2

180634230

-SCG5chr15

32971967

+
In-frameENST00000410066ENST00000494364ZNF385Bchr2

180634230

-SCG5chr15

32971967

+
In-frameENST00000410066ENST00000497208ZNF385Bchr2

180634230

-SCG5chr15

32971967

+
intron-3CDSENST00000336917ENST00000300175ZNF385Bchr2

180634230

-SCG5chr15

32971967

+
intron-3CDSENST00000336917ENST00000413748ZNF385Bchr2

180634230

-SCG5chr15

32971967

+
intron-3CDSENST00000336917ENST00000494364ZNF385Bchr2

180634230

-SCG5chr15

32971967

+
intron-3CDSENST00000336917ENST00000497208ZNF385Bchr2

180634230

-SCG5chr15

32971967

+
intron-3CDSENST00000409343ENST00000300175ZNF385Bchr2

180634230

-SCG5chr15

32971967

+
intron-3CDSENST00000409343ENST00000413748ZNF385Bchr2

180634230

-SCG5chr15

32971967

+
intron-3CDSENST00000409343ENST00000494364ZNF385Bchr2

180634230

-SCG5chr15

32971967

+
intron-3CDSENST00000409343ENST00000497208ZNF385Bchr2

180634230

-SCG5chr15

32971967

+
intron-3CDSENST00000409692ENST00000300175ZNF385Bchr2

180634230

-SCG5chr15

32971967

+
intron-3CDSENST00000409692ENST00000413748ZNF385Bchr2

180634230

-SCG5chr15

32971967

+
intron-3CDSENST00000409692ENST00000494364ZNF385Bchr2

180634230

-SCG5chr15

32971967

+
intron-3CDSENST00000409692ENST00000497208ZNF385Bchr2

180634230

-SCG5chr15

32971967

+
intron-3CDSENST00000466398ENST00000300175ZNF385Bchr2

180634230

-SCG5chr15

32971967

+
intron-3CDSENST00000466398ENST00000413748ZNF385Bchr2

180634230

-SCG5chr15

32971967

+
intron-3CDSENST00000466398ENST00000494364ZNF385Bchr2

180634230

-SCG5chr15

32971967

+
intron-3CDSENST00000466398ENST00000497208ZNF385Bchr2

180634230

-SCG5chr15

32971967

+
intron-3UTRENST00000336917ENST00000498069ZNF385Bchr2

180634230

-SCG5chr15

32971967

+
intron-3UTRENST00000409343ENST00000498069ZNF385Bchr2

180634230

-SCG5chr15

32971967

+
intron-3UTRENST00000409692ENST00000498069ZNF385Bchr2

180634230

-SCG5chr15

32971967

+
intron-3UTRENST00000466398ENST00000498069ZNF385Bchr2

180634230

-SCG5chr15

32971967

+
intron-5UTRENST00000336917ENST00000300175ZNF385Bchr2

180634230

-SCG5chr15

32935787

+
intron-5UTRENST00000336917ENST00000413748ZNF385Bchr2

180634230

-SCG5chr15

32935787

+
intron-5UTRENST00000336917ENST00000494364ZNF385Bchr2

180634230

-SCG5chr15

32935787

+
intron-5UTRENST00000336917ENST00000497208ZNF385Bchr2

180634230

-SCG5chr15

32935787

+
intron-5UTRENST00000409343ENST00000300175ZNF385Bchr2

180634230

-SCG5chr15

32935787

+
intron-5UTRENST00000409343ENST00000413748ZNF385Bchr2

180634230

-SCG5chr15

32935787

+
intron-5UTRENST00000409343ENST00000494364ZNF385Bchr2

180634230

-SCG5chr15

32935787

+
intron-5UTRENST00000409343ENST00000497208ZNF385Bchr2

180634230

-SCG5chr15

32935787

+
intron-5UTRENST00000409692ENST00000300175ZNF385Bchr2

180634230

-SCG5chr15

32935787

+
intron-5UTRENST00000409692ENST00000413748ZNF385Bchr2

180634230

-SCG5chr15

32935787

+
intron-5UTRENST00000409692ENST00000494364ZNF385Bchr2

180634230

-SCG5chr15

32935787

+
intron-5UTRENST00000409692ENST00000497208ZNF385Bchr2

180634230

-SCG5chr15

32935787

+
intron-5UTRENST00000466398ENST00000300175ZNF385Bchr2

180634230

-SCG5chr15

32935787

+
intron-5UTRENST00000466398ENST00000413748ZNF385Bchr2

180634230

-SCG5chr15

32935787

+
intron-5UTRENST00000466398ENST00000494364ZNF385Bchr2

180634230

-SCG5chr15

32935787

+
intron-5UTRENST00000466398ENST00000497208ZNF385Bchr2

180634230

-SCG5chr15

32935787

+
intron-intronENST00000336917ENST00000498069ZNF385Bchr2

180634230

-SCG5chr15

32935787

+
intron-intronENST00000409343ENST00000498069ZNF385Bchr2

180634230

-SCG5chr15

32935787

+
intron-intronENST00000409692ENST00000498069ZNF385Bchr2

180634230

-SCG5chr15

32935787

+
intron-intronENST00000466398ENST00000498069ZNF385Bchr2

180634230

-SCG5chr15

32935787

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000410066ZNF385Bchr2180634230-ENST00000413748SCG5chr1532971967+17568575591266235
ENST00000410066ZNF385Bchr2180634230-ENST00000300175SCG5chr1532971967+17598575591269236
ENST00000410066ZNF385Bchr2180634230-ENST00000494364SCG5chr1532971967+16928575591212217
ENST00000410066ZNF385Bchr2180634230-ENST00000497208SCG5chr1532971967+14968575591215218

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000410066ENST00000413748ZNF385Bchr2180634230-SCG5chr1532971967+0.0012514240.99874854
ENST00000410066ENST00000300175ZNF385Bchr2180634230-SCG5chr1532971967+0.0013702620.9986298
ENST00000410066ENST00000494364ZNF385Bchr2180634230-SCG5chr1532971967+0.0011993950.99880064
ENST00000410066ENST00000497208ZNF385Bchr2180634230-SCG5chr1532971967+0.0015470030.998453

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Fusion Genomic Features for ZNF385B-SCG5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ZNF385Bchr2180634229-SCG5chr1532935786+6.14E-060.9999938
ZNF385Bchr2180634229-SCG5chr1532971966+7.62E-091
ZNF385Bchr2180634229-SCG5chr1532935786+6.14E-060.9999938
ZNF385Bchr2180634229-SCG5chr1532971966+7.62E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ZNF385B-SCG5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:180634230/chr15:32971967)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF385Bchr2:180634230chr15:32971967ENST00000410066-31034_6484472.0Zinc fingerNote=Matrin-type 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF385Bchr2:180634230chr15:32971967ENST00000336917-181_930370.0RegionNote=Required for induction of apoptosis
HgeneZNF385Bchr2:180634230chr15:32971967ENST00000409343-181_930396.0RegionNote=Required for induction of apoptosis
HgeneZNF385Bchr2:180634230chr15:32971967ENST00000409692-191_930370.0RegionNote=Required for induction of apoptosis
HgeneZNF385Bchr2:180634230chr15:32971967ENST00000410066-3101_9384472.0RegionNote=Required for induction of apoptosis
HgeneZNF385Bchr2:180634230chr15:32971967ENST00000336917-18157_1870370.0Zinc fingerNote=Matrin-type 2
HgeneZNF385Bchr2:180634230chr15:32971967ENST00000336917-18282_3160370.0Zinc fingerNote=Matrin-type 3
HgeneZNF385Bchr2:180634230chr15:32971967ENST00000336917-18348_3780370.0Zinc fingerNote=Matrin-type 4
HgeneZNF385Bchr2:180634230chr15:32971967ENST00000336917-1834_640370.0Zinc fingerNote=Matrin-type 1
HgeneZNF385Bchr2:180634230chr15:32971967ENST00000409343-18157_1870396.0Zinc fingerNote=Matrin-type 2
HgeneZNF385Bchr2:180634230chr15:32971967ENST00000409343-18282_3160396.0Zinc fingerNote=Matrin-type 3
HgeneZNF385Bchr2:180634230chr15:32971967ENST00000409343-18348_3780396.0Zinc fingerNote=Matrin-type 4
HgeneZNF385Bchr2:180634230chr15:32971967ENST00000409343-1834_640396.0Zinc fingerNote=Matrin-type 1
HgeneZNF385Bchr2:180634230chr15:32971967ENST00000409692-19157_1870370.0Zinc fingerNote=Matrin-type 2
HgeneZNF385Bchr2:180634230chr15:32971967ENST00000409692-19282_3160370.0Zinc fingerNote=Matrin-type 3
HgeneZNF385Bchr2:180634230chr15:32971967ENST00000409692-19348_3780370.0Zinc fingerNote=Matrin-type 4
HgeneZNF385Bchr2:180634230chr15:32971967ENST00000409692-1934_640370.0Zinc fingerNote=Matrin-type 1
HgeneZNF385Bchr2:180634230chr15:32971967ENST00000410066-310157_18784472.0Zinc fingerNote=Matrin-type 2
HgeneZNF385Bchr2:180634230chr15:32971967ENST00000410066-310282_31684472.0Zinc fingerNote=Matrin-type 3
HgeneZNF385Bchr2:180634230chr15:32971967ENST00000410066-310348_37884472.0Zinc fingerNote=Matrin-type 4


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Fusion Gene Sequence for ZNF385B-SCG5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>101964_101964_1_ZNF385B-SCG5_ZNF385B_chr2_180634230_ENST00000410066_SCG5_chr15_32971967_ENST00000300175_length(transcript)=1759nt_BP=857nt
GCACGTCCAAACCCCGGGGTCCTCGGCCAGGCCAGGGGGGCGGGCGTGCGGCGGGGCCGGGCCGGGCCGGGCGCGCCCAGCGGGCTCCGG
GCACACGCCCCTCACCTGGGCGAGGCCCGGTGCGCAGGCGCTCAGCGCGGGGGCAGCGGCCGGGCGCTTAAGCCCGGCGCGGGCAAGAGT
TGGACAGTTCAGGGGCCGCGCCGGGCCGAGCTGTCGCCCGCGCCACCTCCACCGCCGCCGCTGCTACCGCCACCGCCACCGCCTGGGCTG
CAGCAGATCGCGGGAGAACGTCTGCGCGAAGCCCCGGTGCAGCCCTGGCGGGACCGCAGCAACCACCGGAGCGTGAGCAACAGCTTCCCG
GCTGGAGGAGCCACTGCCCCACGCGCCCGCGGCCCGCGCGCCGAGATGTTCTACATTTCAACTCCATCAAATATTAAATTGATGTTTATG
GGCTAACCTGGAAACCGAAAAACAGTTTGTTTCACTACAAGAATAAGAAAATATGTCCAAATTCCTGTCAGCTGACTTATAAAGGGACTT
TTAGAACACAACCCAATGCATGAGGTACTCCTTAAGCCCTGACAACCATCTTGAAGATGGAATCATGAATATGGCAAATTTTCTACGGGG
CTTTGAAGAAAAGGGGATAAAGAACGACAGGCCTGAGGACCAGTTGAGCAAAGAGAAAAAGAAAATTCTTTTCTCCTTCTGTGAGGTGTG
CAACATCCAGCTGAACTCTGCAGCCCAGGCTCAGGTGCATTCCAACGGCAAATCCCACCGCAAACGAGTGAAGCAGCTGAGTGATGGGCA
GCCCCCACCACCCGCCCAGGCCAGCCCCAGCAGCAACAGCAGCACAGGTGGAGCTCATGAAGGACTTCAGCATTTGGGTCCTTTTGGCAA
CATCCCCAACATCGTGGCAGAGTTGACTGGAGACAACATTCCTAAGGACTTTAGTGAGGATCAGGGGTACCCAGACCCTCCAAATCCCTG
TCCTGTTGGAAAAACAGCAGATGATGGATGTCTAGAAAACACCCCTGACACTGCAGAGTTCAGTCGAGAGTTCCAGTTGCACCAGCATCT
CTTTGATCCGGAACATGACTATCCAGGCTTGGGCAAGTGGAACAAGAAACTCCTTTACGAGAAGATGAAGGGAGGAGAGAGACGAAAGCG
GAGGAGTGTCAATCCATATCTACAAGGACAGAGACTGGATAATGTTGTTGCAAAGAAGTCTGTCCCCCATTTTTCAGATGAGGATAAGGA
TCCAGAGTAAAGAGAAGATGCTAGACGAAAACCCACATTACCTGTTAGGCCTCAGCATGGCTTATGTGCACGTGTAAATGGAGTCCCTGT
GAATGACAGCATGTTTCTTACATAGATAATTATGGATACAAAGCAGCTGTATGTAGATAGTGTATTGTCTTCACACCGATGATTCTGCTT
TTTGCTAAATTAGAATAAGAGCTTTTTTGTTTCTTGGGTTTTTAAAATGTGAATCTGCAATGATCATAAAAATTAAAATGTGAATGTCAA
CAATAAAAAGCAAGACTATGAAAGGCTCAGATTTCTTGCAGTTTAAAATGGTGTCTGAGGTTGTACTATTTTGGCCAAGTCTGTAGAAAG
CTGTCATTTGATTTTGATTATGTAGTTCATCCAGCCCTTGGGCATTGTTATACACCAGTAAAGAAGGCTGTACTCAAGAGGAGGAGCTGA

>101964_101964_1_ZNF385B-SCG5_ZNF385B_chr2_180634230_ENST00000410066_SCG5_chr15_32971967_ENST00000300175_length(amino acids)=236AA_BP=82
MRYSLSPDNHLEDGIMNMANFLRGFEEKGIKNDRPEDQLSKEKKKILFSFCEVCNIQLNSAAQAQVHSNGKSHRKRVKQLSDGQPPPPAQ
ASPSSNSSTGGAHEGLQHLGPFGNIPNIVAELTGDNIPKDFSEDQGYPDPPNPCPVGKTADDGCLENTPDTAEFSREFQLHQHLFDPEHD

--------------------------------------------------------------
>101964_101964_2_ZNF385B-SCG5_ZNF385B_chr2_180634230_ENST00000410066_SCG5_chr15_32971967_ENST00000413748_length(transcript)=1756nt_BP=857nt
GCACGTCCAAACCCCGGGGTCCTCGGCCAGGCCAGGGGGGCGGGCGTGCGGCGGGGCCGGGCCGGGCCGGGCGCGCCCAGCGGGCTCCGG
GCACACGCCCCTCACCTGGGCGAGGCCCGGTGCGCAGGCGCTCAGCGCGGGGGCAGCGGCCGGGCGCTTAAGCCCGGCGCGGGCAAGAGT
TGGACAGTTCAGGGGCCGCGCCGGGCCGAGCTGTCGCCCGCGCCACCTCCACCGCCGCCGCTGCTACCGCCACCGCCACCGCCTGGGCTG
CAGCAGATCGCGGGAGAACGTCTGCGCGAAGCCCCGGTGCAGCCCTGGCGGGACCGCAGCAACCACCGGAGCGTGAGCAACAGCTTCCCG
GCTGGAGGAGCCACTGCCCCACGCGCCCGCGGCCCGCGCGCCGAGATGTTCTACATTTCAACTCCATCAAATATTAAATTGATGTTTATG
GGCTAACCTGGAAACCGAAAAACAGTTTGTTTCACTACAAGAATAAGAAAATATGTCCAAATTCCTGTCAGCTGACTTATAAAGGGACTT
TTAGAACACAACCCAATGCATGAGGTACTCCTTAAGCCCTGACAACCATCTTGAAGATGGAATCATGAATATGGCAAATTTTCTACGGGG
CTTTGAAGAAAAGGGGATAAAGAACGACAGGCCTGAGGACCAGTTGAGCAAAGAGAAAAAGAAAATTCTTTTCTCCTTCTGTGAGGTGTG
CAACATCCAGCTGAACTCTGCAGCCCAGGCTCAGGTGCATTCCAACGGCAAATCCCACCGCAAACGAGTGAAGCAGCTGAGTGATGGGCA
GCCCCCACCACCCGCCCAGGCCAGCCCCAGCAGCAACAGCAGCACAGGTGGAGCTCATGAAGGACTTCAGCATTTGGGTCCTTTTGGCAA
CATCCCCAACATCGTGGCAGAGTTGACTGGAGACAACATTCCTAAGGACTTTAGTGAGGATCAGGGGTACCCAGACCCTCCAAATCCCTG
TCCTGTTGGAAAAACAGATGATGGATGTCTAGAAAACACCCCTGACACTGCAGAGTTCAGTCGAGAGTTCCAGTTGCACCAGCATCTCTT
TGATCCGGAACATGACTATCCAGGCTTGGGCAAGTGGAACAAGAAACTCCTTTACGAGAAGATGAAGGGAGGAGAGAGACGAAAGCGGAG
GAGTGTCAATCCATATCTACAAGGACAGAGACTGGATAATGTTGTTGCAAAGAAGTCTGTCCCCCATTTTTCAGATGAGGATAAGGATCC
AGAGTAAAGAGAAGATGCTAGACGAAAACCCACATTACCTGTTAGGCCTCAGCATGGCTTATGTGCACGTGTAAATGGAGTCCCTGTGAA
TGACAGCATGTTTCTTACATAGATAATTATGGATACAAAGCAGCTGTATGTAGATAGTGTATTGTCTTCACACCGATGATTCTGCTTTTT
GCTAAATTAGAATAAGAGCTTTTTTGTTTCTTGGGTTTTTAAAATGTGAATCTGCAATGATCATAAAAATTAAAATGTGAATGTCAACAA
TAAAAAGCAAGACTATGAAAGGCTCAGATTTCTTGCAGTTTAAAATGGTGTCTGAGGTTGTACTATTTTGGCCAAGTCTGTAGAAAGCTG
TCATTTGATTTTGATTATGTAGTTCATCCAGCCCTTGGGCATTGTTATACACCAGTAAAGAAGGCTGTACTCAAGAGGAGGAGCTGACAC

>101964_101964_2_ZNF385B-SCG5_ZNF385B_chr2_180634230_ENST00000410066_SCG5_chr15_32971967_ENST00000413748_length(amino acids)=235AA_BP=82
MRYSLSPDNHLEDGIMNMANFLRGFEEKGIKNDRPEDQLSKEKKKILFSFCEVCNIQLNSAAQAQVHSNGKSHRKRVKQLSDGQPPPPAQ
ASPSSNSSTGGAHEGLQHLGPFGNIPNIVAELTGDNIPKDFSEDQGYPDPPNPCPVGKTDDGCLENTPDTAEFSREFQLHQHLFDPEHDY

--------------------------------------------------------------
>101964_101964_3_ZNF385B-SCG5_ZNF385B_chr2_180634230_ENST00000410066_SCG5_chr15_32971967_ENST00000494364_length(transcript)=1692nt_BP=857nt
GCACGTCCAAACCCCGGGGTCCTCGGCCAGGCCAGGGGGGCGGGCGTGCGGCGGGGCCGGGCCGGGCCGGGCGCGCCCAGCGGGCTCCGG
GCACACGCCCCTCACCTGGGCGAGGCCCGGTGCGCAGGCGCTCAGCGCGGGGGCAGCGGCCGGGCGCTTAAGCCCGGCGCGGGCAAGAGT
TGGACAGTTCAGGGGCCGCGCCGGGCCGAGCTGTCGCCCGCGCCACCTCCACCGCCGCCGCTGCTACCGCCACCGCCACCGCCTGGGCTG
CAGCAGATCGCGGGAGAACGTCTGCGCGAAGCCCCGGTGCAGCCCTGGCGGGACCGCAGCAACCACCGGAGCGTGAGCAACAGCTTCCCG
GCTGGAGGAGCCACTGCCCCACGCGCCCGCGGCCCGCGCGCCGAGATGTTCTACATTTCAACTCCATCAAATATTAAATTGATGTTTATG
GGCTAACCTGGAAACCGAAAAACAGTTTGTTTCACTACAAGAATAAGAAAATATGTCCAAATTCCTGTCAGCTGACTTATAAAGGGACTT
TTAGAACACAACCCAATGCATGAGGTACTCCTTAAGCCCTGACAACCATCTTGAAGATGGAATCATGAATATGGCAAATTTTCTACGGGG
CTTTGAAGAAAAGGGGATAAAGAACGACAGGCCTGAGGACCAGTTGAGCAAAGAGAAAAAGAAAATTCTTTTCTCCTTCTGTGAGGTGTG
CAACATCCAGCTGAACTCTGCAGCCCAGGCTCAGGTGCATTCCAACGGCAAATCCCACCGCAAACGAGTGAAGCAGCTGAGTGATGGGCA
GCCCCCACCACCCGCCCAGGCCAGCCCCAGCAGCAACAGCAGCACAGGTGGAGCTCATGAAGGACTTCAGCATTTGGGTCCTTTTGGCAA
CATCCCCAACATCGTGGCAGAGTTGACTGGAGACAACATTCCTAAGGACTTTAGTGAGGATCAGGGGTACCCAGACCCTCCAAATCCCTG
TCCTGTTGGAAAAACAGATGATGGATGTCTAGAAAACACCCCTGACACTGCAGAGTTCAGTCGAGAGTTCCAGTTGCACCAGCATCTCTT
TGATCCGGAACATGACTATCCAGGCTTGGGCAAGTGGAGTGTCAATCCATATCTACAAGGACAGAGACTGGATAATGTTGTTGCAAAGAA
GTCTGTCCCCCATTTTTCAGATGAGGATAAGGATCCAGAGTAAAGAGAAGATGCTAGACGAAAACCCACATTACCTGTTAGGCCTCAGCA
TGGCTTATGTGCACGTGTAAATGGAGTCCCTGTGAATGACAGCATGTTTCTTACATAGATAATTATGGATACAAAGCAGCTGTATGTAGA
TAGTGTATTGTCTTCACACCGATGATTCTGCTTTTTGCTAAATTAGAATAAGAGCTTTTTTGTTTCTTGGGTTTTTAAAATGTGAATCTG
CAATGATCATAAAAATTAAAATGTGAATGTCAACAATAAAAAGCAAGACTATGAAAGGCTCAGATTTCTTGCAGTTTAAAATGGTGTCTG
AGGTTGTACTATTTTGGCCAAGTCTGTAGAAAGCTGTCATTTGATTTTGATTATGTAGTTCATCCAGCCCTTGGGCATTGTTATACACCA

>101964_101964_3_ZNF385B-SCG5_ZNF385B_chr2_180634230_ENST00000410066_SCG5_chr15_32971967_ENST00000494364_length(amino acids)=217AA_BP=82
MRYSLSPDNHLEDGIMNMANFLRGFEEKGIKNDRPEDQLSKEKKKILFSFCEVCNIQLNSAAQAQVHSNGKSHRKRVKQLSDGQPPPPAQ
ASPSSNSSTGGAHEGLQHLGPFGNIPNIVAELTGDNIPKDFSEDQGYPDPPNPCPVGKTDDGCLENTPDTAEFSREFQLHQHLFDPEHDY

--------------------------------------------------------------
>101964_101964_4_ZNF385B-SCG5_ZNF385B_chr2_180634230_ENST00000410066_SCG5_chr15_32971967_ENST00000497208_length(transcript)=1496nt_BP=857nt
GCACGTCCAAACCCCGGGGTCCTCGGCCAGGCCAGGGGGGCGGGCGTGCGGCGGGGCCGGGCCGGGCCGGGCGCGCCCAGCGGGCTCCGG
GCACACGCCCCTCACCTGGGCGAGGCCCGGTGCGCAGGCGCTCAGCGCGGGGGCAGCGGCCGGGCGCTTAAGCCCGGCGCGGGCAAGAGT
TGGACAGTTCAGGGGCCGCGCCGGGCCGAGCTGTCGCCCGCGCCACCTCCACCGCCGCCGCTGCTACCGCCACCGCCACCGCCTGGGCTG
CAGCAGATCGCGGGAGAACGTCTGCGCGAAGCCCCGGTGCAGCCCTGGCGGGACCGCAGCAACCACCGGAGCGTGAGCAACAGCTTCCCG
GCTGGAGGAGCCACTGCCCCACGCGCCCGCGGCCCGCGCGCCGAGATGTTCTACATTTCAACTCCATCAAATATTAAATTGATGTTTATG
GGCTAACCTGGAAACCGAAAAACAGTTTGTTTCACTACAAGAATAAGAAAATATGTCCAAATTCCTGTCAGCTGACTTATAAAGGGACTT
TTAGAACACAACCCAATGCATGAGGTACTCCTTAAGCCCTGACAACCATCTTGAAGATGGAATCATGAATATGGCAAATTTTCTACGGGG
CTTTGAAGAAAAGGGGATAAAGAACGACAGGCCTGAGGACCAGTTGAGCAAAGAGAAAAAGAAAATTCTTTTCTCCTTCTGTGAGGTGTG
CAACATCCAGCTGAACTCTGCAGCCCAGGCTCAGGTGCATTCCAACGGCAAATCCCACCGCAAACGAGTGAAGCAGCTGAGTGATGGGCA
GCCCCCACCACCCGCCCAGGCCAGCCCCAGCAGCAACAGCAGCACAGGTGGAGCTCATGAAGGACTTCAGCATTTGGGTCCTTTTGGCAA
CATCCCCAACATCGTGGCAGAGTTGACTGGAGACAACATTCCTAAGGACTTTAGTGAGGATCAGGGGTACCCAGACCCTCCAAATCCCTG
TCCTGTTGGAAAAACAGCAGATGATGGATGTCTAGAAAACACCCCTGACACTGCAGAGTTCAGTCGAGAGTTCCAGTTGCACCAGCATCT
CTTTGATCCGGAACATGACTATCCAGGCTTGGGCAAGTGGAGTGTCAATCCATATCTACAAGGACAGAGACTGGATAATGTTGTTGCAAA
GAAGTCTGTCCCCCATTTTTCAGATGAGGATAAGGATCCAGAGTAAAGAGAAGATGCTAGACGAAAACCCACATTACCTGTTAGGCCTCA
GCATGGCTTATGTGCACGTGTAAATGGAGTCCCTGTGAATGACAGCATGTTTCTTACATAGATAATTATGGATACAAAGCAGCTGTATGT
AGATAGTGTATTGTCTTCACACCGATGATTCTGCTTTTTGCTAAATTAGAATAAGAGCTTTTTTGTTTCTTGGGTTTTTAAAATGTGAAT

>101964_101964_4_ZNF385B-SCG5_ZNF385B_chr2_180634230_ENST00000410066_SCG5_chr15_32971967_ENST00000497208_length(amino acids)=218AA_BP=82
MRYSLSPDNHLEDGIMNMANFLRGFEEKGIKNDRPEDQLSKEKKKILFSFCEVCNIQLNSAAQAQVHSNGKSHRKRVKQLSDGQPPPPAQ
ASPSSNSSTGGAHEGLQHLGPFGNIPNIVAELTGDNIPKDFSEDQGYPDPPNPCPVGKTADDGCLENTPDTAEFSREFQLHQHLFDPEHD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZNF385B-SCG5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneZNF385Bchr2:180634230chr15:32971967ENST00000336917-1894_4710370.0p53/TP53
HgeneZNF385Bchr2:180634230chr15:32971967ENST00000409343-1894_4710396.0p53/TP53
HgeneZNF385Bchr2:180634230chr15:32971967ENST00000409692-1994_4710370.0p53/TP53
HgeneZNF385Bchr2:180634230chr15:32971967ENST00000410066-31094_47184.33333333333333472.0p53/TP53


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF385B-SCG5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF385B-SCG5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource