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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF398-UBE3C (FusionGDB2 ID:101990)

Fusion Gene Summary for ZNF398-UBE3C

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF398-UBE3C
Fusion gene ID: 101990
HgeneTgene
Gene symbol

ZNF398

UBE3C

Gene ID

57541

9690

Gene namezinc finger protein 398ubiquitin protein ligase E3C
SynonymsP51|P71|ZER6HECTH2
Cytomap

7q36.1

7q36.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 398zinc finger DNA binding protein ZER6zinc finger DNA binding protein p52/p71zinc finger-estrogen receptor interaction, clone 6ubiquitin-protein ligase E3CHECT-type ubiquitin transferase E3Cubiquitin-protein isopeptide ligase (E3)
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000335901, ENST00000420008, 
ENST00000426851, ENST00000475153, 
ENST00000483892, ENST00000491174, 
ENST00000540950, ENST00000485111, 
ENST00000389103, ENST00000348165, 
Fusion gene scores* DoF score6 X 6 X 4=14411 X 13 X 7=1001
# samples 613
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/1001*10)=-2.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF398 [Title/Abstract] AND UBE3C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF398(148864022)-UBE3C(157049608), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneUBE3C

GO:0000209

protein polyubiquitination

11278995


check buttonFusion gene breakpoints across ZNF398 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across UBE3C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4PD-01AZNF398chr7

148864022

+UBE3Cchr7

157049608

+


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Fusion Gene ORF analysis for ZNF398-UBE3C

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000335901ENST00000389103ZNF398chr7

148864022

+UBE3Cchr7

157049608

+
5CDS-intronENST00000420008ENST00000389103ZNF398chr7

148864022

+UBE3Cchr7

157049608

+
5CDS-intronENST00000426851ENST00000389103ZNF398chr7

148864022

+UBE3Cchr7

157049608

+
5CDS-intronENST00000475153ENST00000389103ZNF398chr7

148864022

+UBE3Cchr7

157049608

+
5CDS-intronENST00000483892ENST00000389103ZNF398chr7

148864022

+UBE3Cchr7

157049608

+
5CDS-intronENST00000491174ENST00000389103ZNF398chr7

148864022

+UBE3Cchr7

157049608

+
5CDS-intronENST00000540950ENST00000389103ZNF398chr7

148864022

+UBE3Cchr7

157049608

+
In-frameENST00000335901ENST00000348165ZNF398chr7

148864022

+UBE3Cchr7

157049608

+
In-frameENST00000420008ENST00000348165ZNF398chr7

148864022

+UBE3Cchr7

157049608

+
In-frameENST00000426851ENST00000348165ZNF398chr7

148864022

+UBE3Cchr7

157049608

+
In-frameENST00000475153ENST00000348165ZNF398chr7

148864022

+UBE3Cchr7

157049608

+
In-frameENST00000483892ENST00000348165ZNF398chr7

148864022

+UBE3Cchr7

157049608

+
In-frameENST00000491174ENST00000348165ZNF398chr7

148864022

+UBE3Cchr7

157049608

+
In-frameENST00000540950ENST00000348165ZNF398chr7

148864022

+UBE3Cchr7

157049608

+
intron-3CDSENST00000485111ENST00000348165ZNF398chr7

148864022

+UBE3Cchr7

157049608

+
intron-intronENST00000485111ENST00000389103ZNF398chr7

148864022

+UBE3Cchr7

157049608

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000426851ZNF398chr7148864022+ENST00000348165UBE3Cchr7157049608+29189993501300316
ENST00000420008ZNF398chr7148864022+ENST00000348165UBE3Cchr7157049608+2855936621237391
ENST00000475153ZNF398chr7148864022+ENST00000348165UBE3Cchr7157049608+2847928541229391
ENST00000483892ZNF398chr7148864022+ENST00000348165UBE3Cchr7157049608+26907713951072225
ENST00000491174ZNF398chr7148864022+ENST00000348165UBE3Cchr7157049608+27468271511128325
ENST00000540950ZNF398chr7148864022+ENST00000348165UBE3Cchr7157049608+27368171411118325
ENST00000335901ZNF398chr7148864022+ENST00000348165UBE3Cchr7157049608+26797601111061316

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000426851ENST00000348165ZNF398chr7148864022+UBE3Cchr7157049608+0.438739030.56126094
ENST00000420008ENST00000348165ZNF398chr7148864022+UBE3Cchr7157049608+0.0008286980.9991714
ENST00000475153ENST00000348165ZNF398chr7148864022+UBE3Cchr7157049608+0.0008266710.99917334
ENST00000483892ENST00000348165ZNF398chr7148864022+UBE3Cchr7157049608+0.73808980.26191023
ENST00000491174ENST00000348165ZNF398chr7148864022+UBE3Cchr7157049608+0.0007181070.99928194
ENST00000540950ENST00000348165ZNF398chr7148864022+UBE3Cchr7157049608+0.0006749930.99932504
ENST00000335901ENST00000348165ZNF398chr7148864022+UBE3Cchr7157049608+0.87301770.12698232

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Fusion Genomic Features for ZNF398-UBE3C


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ZNF398chr7148864022+UBE3Cchr7157049607+8.41E-091
ZNF398chr7148864022+UBE3Cchr7157049607+8.41E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ZNF398-UBE3C


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:148864022/chr7:157049608)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF398chr7:148864022chr7:157049608ENST00000475153+46143_214220643.0DomainKRAB
TgeneUBE3Cchr7:148864022chr7:157049608ENST000003891030945_740405.0DomainIQ
TgeneUBE3Cchr7:148864022chr7:157049608ENST0000038910309744_10830405.0DomainHECT
TgeneUBE3Cchr7:148864022chr7:157049608ENST00000389103091_600405.0RegionNote=Cis-determinant of acceptor ubiquitin-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF398chr7:148864022chr7:157049608ENST00000335901+46143_21449472.0DomainKRAB
HgeneZNF398chr7:148864022chr7:157049608ENST00000420008+46143_21449472.0DomainKRAB
HgeneZNF398chr7:148864022chr7:157049608ENST00000426851+57143_21449472.0DomainKRAB
HgeneZNF398chr7:148864022chr7:157049608ENST00000483892+46143_21449472.0DomainKRAB
HgeneZNF398chr7:148864022chr7:157049608ENST00000491174+57143_21449472.0DomainKRAB
HgeneZNF398chr7:148864022chr7:157049608ENST00000335901+46343_36449472.0Zinc fingerC2H2-type 1%3B atypical
HgeneZNF398chr7:148864022chr7:157049608ENST00000335901+46370_39249472.0Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF398chr7:148864022chr7:157049608ENST00000335901+46398_42049472.0Zinc fingerC2H2-type 3
HgeneZNF398chr7:148864022chr7:157049608ENST00000335901+46427_44949472.0Zinc fingerC2H2-type 4
HgeneZNF398chr7:148864022chr7:157049608ENST00000335901+46455_47749472.0Zinc fingerC2H2-type 5
HgeneZNF398chr7:148864022chr7:157049608ENST00000335901+46483_50549472.0Zinc fingerC2H2-type 6
HgeneZNF398chr7:148864022chr7:157049608ENST00000335901+46511_53349472.0Zinc fingerC2H2-type 7
HgeneZNF398chr7:148864022chr7:157049608ENST00000335901+46539_56149472.0Zinc fingerC2H2-type 8
HgeneZNF398chr7:148864022chr7:157049608ENST00000335901+46567_59049472.0Zinc fingerC2H2-type 9
HgeneZNF398chr7:148864022chr7:157049608ENST00000420008+46343_36449472.0Zinc fingerC2H2-type 1%3B atypical
HgeneZNF398chr7:148864022chr7:157049608ENST00000420008+46370_39249472.0Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF398chr7:148864022chr7:157049608ENST00000420008+46398_42049472.0Zinc fingerC2H2-type 3
HgeneZNF398chr7:148864022chr7:157049608ENST00000420008+46427_44949472.0Zinc fingerC2H2-type 4
HgeneZNF398chr7:148864022chr7:157049608ENST00000420008+46455_47749472.0Zinc fingerC2H2-type 5
HgeneZNF398chr7:148864022chr7:157049608ENST00000420008+46483_50549472.0Zinc fingerC2H2-type 6
HgeneZNF398chr7:148864022chr7:157049608ENST00000420008+46511_53349472.0Zinc fingerC2H2-type 7
HgeneZNF398chr7:148864022chr7:157049608ENST00000420008+46539_56149472.0Zinc fingerC2H2-type 8
HgeneZNF398chr7:148864022chr7:157049608ENST00000420008+46567_59049472.0Zinc fingerC2H2-type 9
HgeneZNF398chr7:148864022chr7:157049608ENST00000426851+57343_36449472.0Zinc fingerC2H2-type 1%3B atypical
HgeneZNF398chr7:148864022chr7:157049608ENST00000426851+57370_39249472.0Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF398chr7:148864022chr7:157049608ENST00000426851+57398_42049472.0Zinc fingerC2H2-type 3
HgeneZNF398chr7:148864022chr7:157049608ENST00000426851+57427_44949472.0Zinc fingerC2H2-type 4
HgeneZNF398chr7:148864022chr7:157049608ENST00000426851+57455_47749472.0Zinc fingerC2H2-type 5
HgeneZNF398chr7:148864022chr7:157049608ENST00000426851+57483_50549472.0Zinc fingerC2H2-type 6
HgeneZNF398chr7:148864022chr7:157049608ENST00000426851+57511_53349472.0Zinc fingerC2H2-type 7
HgeneZNF398chr7:148864022chr7:157049608ENST00000426851+57539_56149472.0Zinc fingerC2H2-type 8
HgeneZNF398chr7:148864022chr7:157049608ENST00000426851+57567_59049472.0Zinc fingerC2H2-type 9
HgeneZNF398chr7:148864022chr7:157049608ENST00000475153+46343_364220643.0Zinc fingerC2H2-type 1%3B atypical
HgeneZNF398chr7:148864022chr7:157049608ENST00000475153+46370_392220643.0Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF398chr7:148864022chr7:157049608ENST00000475153+46398_420220643.0Zinc fingerC2H2-type 3
HgeneZNF398chr7:148864022chr7:157049608ENST00000475153+46427_449220643.0Zinc fingerC2H2-type 4
HgeneZNF398chr7:148864022chr7:157049608ENST00000475153+46455_477220643.0Zinc fingerC2H2-type 5
HgeneZNF398chr7:148864022chr7:157049608ENST00000475153+46483_505220643.0Zinc fingerC2H2-type 6
HgeneZNF398chr7:148864022chr7:157049608ENST00000475153+46511_533220643.0Zinc fingerC2H2-type 7
HgeneZNF398chr7:148864022chr7:157049608ENST00000475153+46539_561220643.0Zinc fingerC2H2-type 8
HgeneZNF398chr7:148864022chr7:157049608ENST00000475153+46567_590220643.0Zinc fingerC2H2-type 9
HgeneZNF398chr7:148864022chr7:157049608ENST00000483892+46343_36449472.0Zinc fingerC2H2-type 1%3B atypical
HgeneZNF398chr7:148864022chr7:157049608ENST00000483892+46370_39249472.0Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF398chr7:148864022chr7:157049608ENST00000483892+46398_42049472.0Zinc fingerC2H2-type 3
HgeneZNF398chr7:148864022chr7:157049608ENST00000483892+46427_44949472.0Zinc fingerC2H2-type 4
HgeneZNF398chr7:148864022chr7:157049608ENST00000483892+46455_47749472.0Zinc fingerC2H2-type 5
HgeneZNF398chr7:148864022chr7:157049608ENST00000483892+46483_50549472.0Zinc fingerC2H2-type 6
HgeneZNF398chr7:148864022chr7:157049608ENST00000483892+46511_53349472.0Zinc fingerC2H2-type 7
HgeneZNF398chr7:148864022chr7:157049608ENST00000483892+46539_56149472.0Zinc fingerC2H2-type 8
HgeneZNF398chr7:148864022chr7:157049608ENST00000483892+46567_59049472.0Zinc fingerC2H2-type 9
HgeneZNF398chr7:148864022chr7:157049608ENST00000491174+57343_36449472.0Zinc fingerC2H2-type 1%3B atypical
HgeneZNF398chr7:148864022chr7:157049608ENST00000491174+57370_39249472.0Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF398chr7:148864022chr7:157049608ENST00000491174+57398_42049472.0Zinc fingerC2H2-type 3
HgeneZNF398chr7:148864022chr7:157049608ENST00000491174+57427_44949472.0Zinc fingerC2H2-type 4
HgeneZNF398chr7:148864022chr7:157049608ENST00000491174+57455_47749472.0Zinc fingerC2H2-type 5
HgeneZNF398chr7:148864022chr7:157049608ENST00000491174+57483_50549472.0Zinc fingerC2H2-type 6
HgeneZNF398chr7:148864022chr7:157049608ENST00000491174+57511_53349472.0Zinc fingerC2H2-type 7
HgeneZNF398chr7:148864022chr7:157049608ENST00000491174+57539_56149472.0Zinc fingerC2H2-type 8
HgeneZNF398chr7:148864022chr7:157049608ENST00000491174+57567_59049472.0Zinc fingerC2H2-type 9
TgeneUBE3Cchr7:148864022chr7:157049608ENST00000348165202345_749831084.0DomainIQ
TgeneUBE3Cchr7:148864022chr7:157049608ENST000003481652023744_10839831084.0DomainHECT
TgeneUBE3Cchr7:148864022chr7:157049608ENST0000034816520231_609831084.0RegionNote=Cis-determinant of acceptor ubiquitin-binding


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Fusion Gene Sequence for ZNF398-UBE3C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>101990_101990_1_ZNF398-UBE3C_ZNF398_chr7_148864022_ENST00000335901_UBE3C_chr7_157049608_ENST00000348165_length(transcript)=2679nt_BP=760nt
GACGGAGTTTTGCTCTTATTGCCCAGGCTGGAATGCAATGATGCGATCTCGGCTCACTGAAACCTCGGTCTCCTGGGTTCAAGCGATTGT
CCTGCCTCAGCCTCTGAGTAGCTGAGATTACAGACATCTGAATGGGACTCCGAGTGCCTTACATCCCTGCAGCCCCTTCCTCTTCCTACA
CCCCCAGCAGCAAATGAGGCACACCTGCAGACAGCAGCTATCTCTCTGTGGACAGTGGTGGCCGCCGTGCAGGCTATAGAGAGGAAGGTG
GAGATCCACAGCCGGCGACTCCTACACCTGGAAGGTCGGACAGGGACAGCAGAGAAGAAACTAGCCAGCTGTGAAAAGACAGTTACCGAG
CTTGGGAACCAGCTGGAGGGCAAGTGGGCCGTGCTGGGAACCCTGCTGCAGGAGTACGGGCTGCTGCAGAGGCGGCTGGAGAACTTGGAG
AACCTGCTGCGCAACAGGAACTTCTGGATCCTGCGGCTCCCTCCAGGTATTAAGGGAGATATCCCAAAGGTGCCTGTGGCATTTGATGAT
GTCTCCATCTACTTTTCCACTCCAGAGTGGGAAAAATTAGAAGAATGGCAAAAGGAACTTTACAAGAATATCATGAAGGGCAACTACGAG
TCTCTCATCTCCATGGATTATGCTATAAATCAACCTGATGTCTTATCTCAGATTCAACCAGAAGGGGAACATAATACAGAGGACCAGGCA
GGGCCAGAGGAAAGTGAGATTCCCACAGACCCCAGTGAAGGAGGCTATTCTGCAGACCATCCTGTTATTAAGGTCTTCTGGAGAGTTGTG
GAAGGGTTCACTGATGAAGAAAAGCGCAAACTGCTGAAGTTTGTAACAAGCTGCTCTCGACCCCCTCTCTTGGGGTTTAAGGAGTTGTAT
CCCGCATTTTGTATTCACAACGGAGGCTCCGACCTTGAGCGGCTCCCCACAGCCAGCACCTGCATGAACCTGCTGAAGCTCCCCGAGTTC
TATGACGAGACACTTTTGCGAAGTAAACTTCTCTATGCGATTGAATGTGCCGCTGGCTTTGAGCTGAGCTGAAGCTGATGCTGGGGTCAG
ACCCCTACAGAGAACCAGTGCTTCCTTCGTCAGCAGCGCCTCCCCAGACCCACGAGGATACTCACACTGCACGCCTGAGGCTCTCCTAAG
CTCCTTCTTTCATTCTGCCATTCCTCCCTCCCTTCCTTTTTTAAATGATTTTTATTACGGTGTGGTCACTTATTTAGATGGACATTGCTT
TTCAAATAACTTAAAATAACACGTTATGTGCCATGTGGCTACTTTAGTAATATTGCCAAGAAGAGCACAGTTTTTACACTAGTGGCATCT
CAGTGAAATTAACCAAAGATGAAGCTTTGGCTTTGCTGGTGAGATCAGAGCCCTCCTGAGCAGGCAGCGCCACTCCAGGGTTCAGACAGG
GCTGCACAGGCGGCAGAGATACAGGGTCTGAGGGCTGAGACGCCATGGGGCCGCTGCTGCTTATGTGGTTGGATTGTTTACAAGCCTCAT
TATTAAAACTGAAGGCATTTTTTTTTTCTGCTGCCTTTCCCAAAGTGGTTAGGTTTGGAAAAGAGATGATGATGGTAATATTTTATTTGT
GCTTTTTAAGCCATTTCCCCAAATGGGACTAGCATGCTTGTTTTCAGTATACCGTGGCCTGCCTCATGATGGTTTGGAGATACTGTCTGT
GGATGTGAGGTGGGGACTTCATTCATTGTCCTATTTCTATCTCCACTTTGTGCCTGGAGAGCTTTCAGGGGAGGTGGAGGAGGAGGGTCT
GCCAAGCTACTGCAACATCTGTCACCCACTATACCCAGTTACTTGGGGGAGGACAGACACTGTGGTGTCATTAAAGTTGTTTGAACCAAA
GTGGCGGCTGCATCTTTGTCCCGATGCTAGCCGTGCCGGTCTCCCATCATCCGCTCGCCCTCCTTTCCCCTGGGCTGCGCCCACTTGTCT
TCCTGGATATTTGGGGGTGACTCGCCATGCTTGGCACCCTCTGCTTCCTGGTGCTGCTCTGACTCGAAGACGGGACAGTCCCTGGTGCAC
ATCCAGGGAAGAGGAGTGTCGGTAGTTCTTGCAGTAGGCACTTTATCAGGACCTGACCTGTTGCTGGGTGATTTTAGTCTCTACAAACAG
AAAGCGTTTCAAAGCGTCAGCTGTGGGAGCAGAGTGACCCTTTGCTGATGCTGGGGGGAGGGGATCTAAATCCTCATTTATCTCTTCTAT
GTCTCGTATTTTACTGTCACTGGAGGCTCTGTGGGCTGTCATAGTTAATTGACCATAATTAGCAATATACTTTTAAAGTGGGAAAGCTGA
ATGACACTTTTAAGACAATGAACATTATCAAAACAAAATGTATAATTTCTTAATTTGAATAATAAATTAAGCGTTTAAATGCTATTTGTA
GTCTTGATATACAGAAATAAAATAATTAGGGTTGGTCTTTTTTATTTTAGGTTGTTTTATGTTGAATGTTCTATATCTTATTAGTTAATT
TGTATATTTTATTAGTATTTTGGAAATAGCATATCTGAGACTGAAGAGAAATTGACAATTCACTTATTTGTGGTTTTTTTCTCAGCTATT

>101990_101990_1_ZNF398-UBE3C_ZNF398_chr7_148864022_ENST00000335901_UBE3C_chr7_157049608_ENST00000348165_length(amino acids)=316AA_BP=216
MRLQTSEWDSECLTSLQPLPLPTPPAANEAHLQTAAISLWTVVAAVQAIERKVEIHSRRLLHLEGRTGTAEKKLASCEKTVTELGNQLEG
KWAVLGTLLQEYGLLQRRLENLENLLRNRNFWILRLPPGIKGDIPKVPVAFDDVSIYFSTPEWEKLEEWQKELYKNIMKGNYESLISMDY
AINQPDVLSQIQPEGEHNTEDQAGPEESEIPTDPSEGGYSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHN

--------------------------------------------------------------
>101990_101990_2_ZNF398-UBE3C_ZNF398_chr7_148864022_ENST00000420008_UBE3C_chr7_157049608_ENST00000348165_length(transcript)=2855nt_BP=936nt
AAAGCGCCAGCTGAGGGGCCGCTGCGGGTGGAGTGCGGCGGAGTCGGCCTCGCGACCCCAGCTTGATCCGCCGCCTGCTGCACCGCGCCT
CCGCCGCGTTCCTGCGCGTCCCGAGCCCCGACGGCCGCGTGAGTCCCGTCCGTGCGGGGAAGGCAGGGCCGGGTCGGCGCCGCCTGTGGA
GAGGACCCGGCGGCCGGGCCTGCTTGGAGCCGGGCGCGGTGGCAGCGGCGGCAGCGGCGGCGACTTCCGAGGCCCGGGCTAGACAGCGCA
GGGCCATGGCTGAGGCGGCCCCGGCCCCGACATCTGAATGGGACTCCGAGTGCCTTACATCCCTGCAGCCCCTTCCTCTTCCTACACCCC
CAGCAGCAAATGAGGCACACCTGCAGACAGCAGCTATCTCTCTGTGGACAGTGGTGGCCGCCGTGCAGGCTATAGAGAGGAAGGTGGAGA
TCCACAGCCGGCGACTCCTACACCTGGAAGGTCGGACAGGGACAGCAGAGAAGAAACTAGCCAGCTGTGAAAAGACAGTTACCGAGCTTG
GGAACCAGCTGGAGGGCAAGTGGGCCGTGCTGGGAACCCTGCTGCAGGAGTACGGGCTGCTGCAGAGGCGGCTGGAGAACTTGGAGAACC
TGCTGCGCAACAGGAACTTCTGGATCCTGCGGCTCCCTCCAGGTATTAAGGGAGATATCCCAAAGGTGCCTGTGGCATTTGATGATGTCT
CCATCTACTTTTCCACTCCAGAGTGGGAAAAATTAGAAGAATGGCAAAAGGAACTTTACAAGAATATCATGAAGGGCAACTACGAGTCTC
TCATCTCCATGGATTATGCTATAAATCAACCTGATGTCTTATCTCAGATTCAACCAGAAGGGGAACATAATACAGAGGACCAGGCAGGGC
CAGAGGAAAGTGAGATTCCCACAGACCCCAGTGAAGGAGGCTATTCTGCAGACCATCCTGTTATTAAGGTCTTCTGGAGAGTTGTGGAAG
GGTTCACTGATGAAGAAAAGCGCAAACTGCTGAAGTTTGTAACAAGCTGCTCTCGACCCCCTCTCTTGGGGTTTAAGGAGTTGTATCCCG
CATTTTGTATTCACAACGGAGGCTCCGACCTTGAGCGGCTCCCCACAGCCAGCACCTGCATGAACCTGCTGAAGCTCCCCGAGTTCTATG
ACGAGACACTTTTGCGAAGTAAACTTCTCTATGCGATTGAATGTGCCGCTGGCTTTGAGCTGAGCTGAAGCTGATGCTGGGGTCAGACCC
CTACAGAGAACCAGTGCTTCCTTCGTCAGCAGCGCCTCCCCAGACCCACGAGGATACTCACACTGCACGCCTGAGGCTCTCCTAAGCTCC
TTCTTTCATTCTGCCATTCCTCCCTCCCTTCCTTTTTTAAATGATTTTTATTACGGTGTGGTCACTTATTTAGATGGACATTGCTTTTCA
AATAACTTAAAATAACACGTTATGTGCCATGTGGCTACTTTAGTAATATTGCCAAGAAGAGCACAGTTTTTACACTAGTGGCATCTCAGT
GAAATTAACCAAAGATGAAGCTTTGGCTTTGCTGGTGAGATCAGAGCCCTCCTGAGCAGGCAGCGCCACTCCAGGGTTCAGACAGGGCTG
CACAGGCGGCAGAGATACAGGGTCTGAGGGCTGAGACGCCATGGGGCCGCTGCTGCTTATGTGGTTGGATTGTTTACAAGCCTCATTATT
AAAACTGAAGGCATTTTTTTTTTCTGCTGCCTTTCCCAAAGTGGTTAGGTTTGGAAAAGAGATGATGATGGTAATATTTTATTTGTGCTT
TTTAAGCCATTTCCCCAAATGGGACTAGCATGCTTGTTTTCAGTATACCGTGGCCTGCCTCATGATGGTTTGGAGATACTGTCTGTGGAT
GTGAGGTGGGGACTTCATTCATTGTCCTATTTCTATCTCCACTTTGTGCCTGGAGAGCTTTCAGGGGAGGTGGAGGAGGAGGGTCTGCCA
AGCTACTGCAACATCTGTCACCCACTATACCCAGTTACTTGGGGGAGGACAGACACTGTGGTGTCATTAAAGTTGTTTGAACCAAAGTGG
CGGCTGCATCTTTGTCCCGATGCTAGCCGTGCCGGTCTCCCATCATCCGCTCGCCCTCCTTTCCCCTGGGCTGCGCCCACTTGTCTTCCT
GGATATTTGGGGGTGACTCGCCATGCTTGGCACCCTCTGCTTCCTGGTGCTGCTCTGACTCGAAGACGGGACAGTCCCTGGTGCACATCC
AGGGAAGAGGAGTGTCGGTAGTTCTTGCAGTAGGCACTTTATCAGGACCTGACCTGTTGCTGGGTGATTTTAGTCTCTACAAACAGAAAG
CGTTTCAAAGCGTCAGCTGTGGGAGCAGAGTGACCCTTTGCTGATGCTGGGGGGAGGGGATCTAAATCCTCATTTATCTCTTCTATGTCT
CGTATTTTACTGTCACTGGAGGCTCTGTGGGCTGTCATAGTTAATTGACCATAATTAGCAATATACTTTTAAAGTGGGAAAGCTGAATGA
CACTTTTAAGACAATGAACATTATCAAAACAAAATGTATAATTTCTTAATTTGAATAATAAATTAAGCGTTTAAATGCTATTTGTAGTCT
TGATATACAGAAATAAAATAATTAGGGTTGGTCTTTTTTATTTTAGGTTGTTTTATGTTGAATGTTCTATATCTTATTAGTTAATTTGTA
TATTTTATTAGTATTTTGGAAATAGCATATCTGAGACTGAAGAGAAATTGACAATTCACTTATTTGTGGTTTTTTTCTCAGCTATTCTGA

>101990_101990_2_ZNF398-UBE3C_ZNF398_chr7_148864022_ENST00000420008_UBE3C_chr7_157049608_ENST00000348165_length(amino acids)=391AA_BP=291
MIRRLLHRASAAFLRVPSPDGRVSPVRAGKAGPGRRRLWRGPGGRACLEPGAVAAAAAAATSEARARQRRAMAEAAPAPTSEWDSECLTS
LQPLPLPTPPAANEAHLQTAAISLWTVVAAVQAIERKVEIHSRRLLHLEGRTGTAEKKLASCEKTVTELGNQLEGKWAVLGTLLQEYGLL
QRRLENLENLLRNRNFWILRLPPGIKGDIPKVPVAFDDVSIYFSTPEWEKLEEWQKELYKNIMKGNYESLISMDYAINQPDVLSQIQPEG
EHNTEDQAGPEESEIPTDPSEGGYSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLERLPTASTCM

--------------------------------------------------------------
>101990_101990_3_ZNF398-UBE3C_ZNF398_chr7_148864022_ENST00000426851_UBE3C_chr7_157049608_ENST00000348165_length(transcript)=2918nt_BP=999nt
TCGGTCCTCAGAGGAGGGGCCCGGGCACCCTCCGTGCGGGCCGCAGCACGCCGGTCTTTGAGGGACCCTTGGACTCCCGGATCTGCATGC
GAGGGATGCGGTCGAAGACGAGATGAGGGAGCTGACGGGAGGGGAAACGGAGGGGCAGGTGAACATGGAGAGAGCAGGAACAGGGAGAGA
GTAGGGACAGCGACTGGGAGACGCGCTCCACAGAAACCCGGACTGAGAGGCAGCGAGAGGACGTAGTCTTGCTCTGTTGCCTAGGCTGGA
GTAGAGTGGTGTGATCTTGGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGTTGGGATTAC
AGACATCTGAATGGGACTCCGAGTGCCTTACATCCCTGCAGCCCCTTCCTCTTCCTACACCCCCAGCAGCAAATGAGGCACACCTGCAGA
CAGCAGCTATCTCTCTGTGGACAGTGGTGGCCGCCGTGCAGGCTATAGAGAGGAAGGTGGAGATCCACAGCCGGCGACTCCTACACCTGG
AAGGTCGGACAGGGACAGCAGAGAAGAAACTAGCCAGCTGTGAAAAGACAGTTACCGAGCTTGGGAACCAGCTGGAGGGCAAGTGGGCCG
TGCTGGGAACCCTGCTGCAGGAGTACGGGCTGCTGCAGAGGCGGCTGGAGAACTTGGAGAACCTGCTGCGCAACAGGAACTTCTGGATCC
TGCGGCTCCCTCCAGGTATTAAGGGAGATATCCCAAAGGTGCCTGTGGCATTTGATGATGTCTCCATCTACTTTTCCACTCCAGAGTGGG
AAAAATTAGAAGAATGGCAAAAGGAACTTTACAAGAATATCATGAAGGGCAACTACGAGTCTCTCATCTCCATGGATTATGCTATAAATC
AACCTGATGTCTTATCTCAGATTCAACCAGAAGGGGAACATAATACAGAGGACCAGGCAGGGCCAGAGGAAAGTGAGATTCCCACAGACC
CCAGTGAAGGAGGCTATTCTGCAGACCATCCTGTTATTAAGGTCTTCTGGAGAGTTGTGGAAGGGTTCACTGATGAAGAAAAGCGCAAAC
TGCTGAAGTTTGTAACAAGCTGCTCTCGACCCCCTCTCTTGGGGTTTAAGGAGTTGTATCCCGCATTTTGTATTCACAACGGAGGCTCCG
ACCTTGAGCGGCTCCCCACAGCCAGCACCTGCATGAACCTGCTGAAGCTCCCCGAGTTCTATGACGAGACACTTTTGCGAAGTAAACTTC
TCTATGCGATTGAATGTGCCGCTGGCTTTGAGCTGAGCTGAAGCTGATGCTGGGGTCAGACCCCTACAGAGAACCAGTGCTTCCTTCGTC
AGCAGCGCCTCCCCAGACCCACGAGGATACTCACACTGCACGCCTGAGGCTCTCCTAAGCTCCTTCTTTCATTCTGCCATTCCTCCCTCC
CTTCCTTTTTTAAATGATTTTTATTACGGTGTGGTCACTTATTTAGATGGACATTGCTTTTCAAATAACTTAAAATAACACGTTATGTGC
CATGTGGCTACTTTAGTAATATTGCCAAGAAGAGCACAGTTTTTACACTAGTGGCATCTCAGTGAAATTAACCAAAGATGAAGCTTTGGC
TTTGCTGGTGAGATCAGAGCCCTCCTGAGCAGGCAGCGCCACTCCAGGGTTCAGACAGGGCTGCACAGGCGGCAGAGATACAGGGTCTGA
GGGCTGAGACGCCATGGGGCCGCTGCTGCTTATGTGGTTGGATTGTTTACAAGCCTCATTATTAAAACTGAAGGCATTTTTTTTTTCTGC
TGCCTTTCCCAAAGTGGTTAGGTTTGGAAAAGAGATGATGATGGTAATATTTTATTTGTGCTTTTTAAGCCATTTCCCCAAATGGGACTA
GCATGCTTGTTTTCAGTATACCGTGGCCTGCCTCATGATGGTTTGGAGATACTGTCTGTGGATGTGAGGTGGGGACTTCATTCATTGTCC
TATTTCTATCTCCACTTTGTGCCTGGAGAGCTTTCAGGGGAGGTGGAGGAGGAGGGTCTGCCAAGCTACTGCAACATCTGTCACCCACTA
TACCCAGTTACTTGGGGGAGGACAGACACTGTGGTGTCATTAAAGTTGTTTGAACCAAAGTGGCGGCTGCATCTTTGTCCCGATGCTAGC
CGTGCCGGTCTCCCATCATCCGCTCGCCCTCCTTTCCCCTGGGCTGCGCCCACTTGTCTTCCTGGATATTTGGGGGTGACTCGCCATGCT
TGGCACCCTCTGCTTCCTGGTGCTGCTCTGACTCGAAGACGGGACAGTCCCTGGTGCACATCCAGGGAAGAGGAGTGTCGGTAGTTCTTG
CAGTAGGCACTTTATCAGGACCTGACCTGTTGCTGGGTGATTTTAGTCTCTACAAACAGAAAGCGTTTCAAAGCGTCAGCTGTGGGAGCA
GAGTGACCCTTTGCTGATGCTGGGGGGAGGGGATCTAAATCCTCATTTATCTCTTCTATGTCTCGTATTTTACTGTCACTGGAGGCTCTG
TGGGCTGTCATAGTTAATTGACCATAATTAGCAATATACTTTTAAAGTGGGAAAGCTGAATGACACTTTTAAGACAATGAACATTATCAA
AACAAAATGTATAATTTCTTAATTTGAATAATAAATTAAGCGTTTAAATGCTATTTGTAGTCTTGATATACAGAAATAAAATAATTAGGG
TTGGTCTTTTTTATTTTAGGTTGTTTTATGTTGAATGTTCTATATCTTATTAGTTAATTTGTATATTTTATTAGTATTTTGGAAATAGCA
TATCTGAGACTGAAGAGAAATTGACAATTCACTTATTTGTGGTTTTTTTCTCAGCTATTCTGAGCTTATTTATTTATTTGTATGTTCTAA

>101990_101990_3_ZNF398-UBE3C_ZNF398_chr7_148864022_ENST00000426851_UBE3C_chr7_157049608_ENST00000348165_length(amino acids)=316AA_BP=216
MGLQTSEWDSECLTSLQPLPLPTPPAANEAHLQTAAISLWTVVAAVQAIERKVEIHSRRLLHLEGRTGTAEKKLASCEKTVTELGNQLEG
KWAVLGTLLQEYGLLQRRLENLENLLRNRNFWILRLPPGIKGDIPKVPVAFDDVSIYFSTPEWEKLEEWQKELYKNIMKGNYESLISMDY
AINQPDVLSQIQPEGEHNTEDQAGPEESEIPTDPSEGGYSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHN

--------------------------------------------------------------
>101990_101990_4_ZNF398-UBE3C_ZNF398_chr7_148864022_ENST00000475153_UBE3C_chr7_157049608_ENST00000348165_length(transcript)=2847nt_BP=928nt
AGCTGAGGGGCCGCTGCGGGTGGAGTGCGGCGGAGTCGGCCTCGCGACCCCAGCTTGATCCGCCGCCTGCTGCACCGCGCCTCCGCCGCG
TTCCTGCGCGTCCCGAGCCCCGACGGCCGCGTGAGTCCCGTCCGTGCGGGGAAGGCAGGGCCGGGTCGGCGCCGCCTGTGGAGAGGACCC
GGCGGCCGGGCCTGCTTGGAGCCGGGCGCGGTGGCAGCGGCGGCAGCGGCGGCGACTTCCGAGGCCCGGGCTAGACAGCGCAGGGCCATG
GCTGAGGCGGCCCCGGCCCCGACATCTGAATGGGACTCCGAGTGCCTTACATCCCTGCAGCCCCTTCCTCTTCCTACACCCCCAGCAGCA
AATGAGGCACACCTGCAGACAGCAGCTATCTCTCTGTGGACAGTGGTGGCCGCCGTGCAGGCTATAGAGAGGAAGGTGGAGATCCACAGC
CGGCGACTCCTACACCTGGAAGGTCGGACAGGGACAGCAGAGAAGAAACTAGCCAGCTGTGAAAAGACAGTTACCGAGCTTGGGAACCAG
CTGGAGGGCAAGTGGGCCGTGCTGGGAACCCTGCTGCAGGAGTACGGGCTGCTGCAGAGGCGGCTGGAGAACTTGGAGAACCTGCTGCGC
AACAGGAACTTCTGGATCCTGCGGCTCCCTCCAGGTATTAAGGGAGATATCCCAAAGGTGCCTGTGGCATTTGATGATGTCTCCATCTAC
TTTTCCACTCCAGAGTGGGAAAAATTAGAAGAATGGCAAAAGGAACTTTACAAGAATATCATGAAGGGCAACTACGAGTCTCTCATCTCC
ATGGATTATGCTATAAATCAACCTGATGTCTTATCTCAGATTCAACCAGAAGGGGAACATAATACAGAGGACCAGGCAGGGCCAGAGGAA
AGTGAGATTCCCACAGACCCCAGTGAAGGAGGCTATTCTGCAGACCATCCTGTTATTAAGGTCTTCTGGAGAGTTGTGGAAGGGTTCACT
GATGAAGAAAAGCGCAAACTGCTGAAGTTTGTAACAAGCTGCTCTCGACCCCCTCTCTTGGGGTTTAAGGAGTTGTATCCCGCATTTTGT
ATTCACAACGGAGGCTCCGACCTTGAGCGGCTCCCCACAGCCAGCACCTGCATGAACCTGCTGAAGCTCCCCGAGTTCTATGACGAGACA
CTTTTGCGAAGTAAACTTCTCTATGCGATTGAATGTGCCGCTGGCTTTGAGCTGAGCTGAAGCTGATGCTGGGGTCAGACCCCTACAGAG
AACCAGTGCTTCCTTCGTCAGCAGCGCCTCCCCAGACCCACGAGGATACTCACACTGCACGCCTGAGGCTCTCCTAAGCTCCTTCTTTCA
TTCTGCCATTCCTCCCTCCCTTCCTTTTTTAAATGATTTTTATTACGGTGTGGTCACTTATTTAGATGGACATTGCTTTTCAAATAACTT
AAAATAACACGTTATGTGCCATGTGGCTACTTTAGTAATATTGCCAAGAAGAGCACAGTTTTTACACTAGTGGCATCTCAGTGAAATTAA
CCAAAGATGAAGCTTTGGCTTTGCTGGTGAGATCAGAGCCCTCCTGAGCAGGCAGCGCCACTCCAGGGTTCAGACAGGGCTGCACAGGCG
GCAGAGATACAGGGTCTGAGGGCTGAGACGCCATGGGGCCGCTGCTGCTTATGTGGTTGGATTGTTTACAAGCCTCATTATTAAAACTGA
AGGCATTTTTTTTTTCTGCTGCCTTTCCCAAAGTGGTTAGGTTTGGAAAAGAGATGATGATGGTAATATTTTATTTGTGCTTTTTAAGCC
ATTTCCCCAAATGGGACTAGCATGCTTGTTTTCAGTATACCGTGGCCTGCCTCATGATGGTTTGGAGATACTGTCTGTGGATGTGAGGTG
GGGACTTCATTCATTGTCCTATTTCTATCTCCACTTTGTGCCTGGAGAGCTTTCAGGGGAGGTGGAGGAGGAGGGTCTGCCAAGCTACTG
CAACATCTGTCACCCACTATACCCAGTTACTTGGGGGAGGACAGACACTGTGGTGTCATTAAAGTTGTTTGAACCAAAGTGGCGGCTGCA
TCTTTGTCCCGATGCTAGCCGTGCCGGTCTCCCATCATCCGCTCGCCCTCCTTTCCCCTGGGCTGCGCCCACTTGTCTTCCTGGATATTT
GGGGGTGACTCGCCATGCTTGGCACCCTCTGCTTCCTGGTGCTGCTCTGACTCGAAGACGGGACAGTCCCTGGTGCACATCCAGGGAAGA
GGAGTGTCGGTAGTTCTTGCAGTAGGCACTTTATCAGGACCTGACCTGTTGCTGGGTGATTTTAGTCTCTACAAACAGAAAGCGTTTCAA
AGCGTCAGCTGTGGGAGCAGAGTGACCCTTTGCTGATGCTGGGGGGAGGGGATCTAAATCCTCATTTATCTCTTCTATGTCTCGTATTTT
ACTGTCACTGGAGGCTCTGTGGGCTGTCATAGTTAATTGACCATAATTAGCAATATACTTTTAAAGTGGGAAAGCTGAATGACACTTTTA
AGACAATGAACATTATCAAAACAAAATGTATAATTTCTTAATTTGAATAATAAATTAAGCGTTTAAATGCTATTTGTAGTCTTGATATAC
AGAAATAAAATAATTAGGGTTGGTCTTTTTTATTTTAGGTTGTTTTATGTTGAATGTTCTATATCTTATTAGTTAATTTGTATATTTTAT
TAGTATTTTGGAAATAGCATATCTGAGACTGAAGAGAAATTGACAATTCACTTATTTGTGGTTTTTTTCTCAGCTATTCTGAGCTTATTT

>101990_101990_4_ZNF398-UBE3C_ZNF398_chr7_148864022_ENST00000475153_UBE3C_chr7_157049608_ENST00000348165_length(amino acids)=391AA_BP=291
MIRRLLHRASAAFLRVPSPDGRVSPVRAGKAGPGRRRLWRGPGGRACLEPGAVAAAAAAATSEARARQRRAMAEAAPAPTSEWDSECLTS
LQPLPLPTPPAANEAHLQTAAISLWTVVAAVQAIERKVEIHSRRLLHLEGRTGTAEKKLASCEKTVTELGNQLEGKWAVLGTLLQEYGLL
QRRLENLENLLRNRNFWILRLPPGIKGDIPKVPVAFDDVSIYFSTPEWEKLEEWQKELYKNIMKGNYESLISMDYAINQPDVLSQIQPEG
EHNTEDQAGPEESEIPTDPSEGGYSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLERLPTASTCM

--------------------------------------------------------------
>101990_101990_5_ZNF398-UBE3C_ZNF398_chr7_148864022_ENST00000483892_UBE3C_chr7_157049608_ENST00000348165_length(transcript)=2690nt_BP=771nt
GGCCGCGGGAGCGTTCGTCACCAGCAATCTGAGCGGTGGCGCGGGCGGCATTTAAGTGTGCGGAGGCGCATTCCCGCCGCGCTGCGTGAC
GCCTGGGCTCCCGGCACCGGACTCGGGACACGCGGGAGGCCCTCCCGAAATAGCTGCCGAATGAATGACATCTGAATGGGACTCCGAGTG
CCTTACATCCCTGCAGCCCCTTCCTCTTCCTACACCCCCAGCAGCAAATGAGGCACACCTGCAGACAGCAGCTATCTCTCTGTGGACAGT
GGTGGCCGCCGTGCAGGCTATAGAGAGGAAGGTGGAGATCCACAGCCGGCGACTCCTACACCTGGAAGGTCGGACAGGGACAGCAGAGAA
GAAACTAGCCAGCTGTGAAAAGACAGTTACCGAGCTTGGGAACCAGCTGGAGGGCAAGTGGGCCGTGCTGGGAACCCTGCTGCAGGAGTA
CGGGCTGCTGCAGAGGCGGCTGGAGAACTTGGAGAACCTGCTGCGCAACAGGAACTTCTGGATCCTGCGGCTCCCTCCAGGTGCCTGTGG
CATTTGATGATGTCTCCATCTACTTTTCCACTCCAGAGTGGGAAAAATTAGAAGAATGGCAAAAGGAACTTTACAAGAATATCATGAAGG
GCAACTACGAGTCTCTCATCTCCATGGATTATGCTATAAATCAACCTGATGTCTTATCTCAGATTCAACCAGAAGGGGAACATAATACAG
AGGACCAGGCAGGGCCAGAGGAAAGTGAGATTCCCACAGACCCCAGTGAAGGAGGCTATTCTGCAGACCATCCTGTTATTAAGGTCTTCT
GGAGAGTTGTGGAAGGGTTCACTGATGAAGAAAAGCGCAAACTGCTGAAGTTTGTAACAAGCTGCTCTCGACCCCCTCTCTTGGGGTTTA
AGGAGTTGTATCCCGCATTTTGTATTCACAACGGAGGCTCCGACCTTGAGCGGCTCCCCACAGCCAGCACCTGCATGAACCTGCTGAAGC
TCCCCGAGTTCTATGACGAGACACTTTTGCGAAGTAAACTTCTCTATGCGATTGAATGTGCCGCTGGCTTTGAGCTGAGCTGAAGCTGAT
GCTGGGGTCAGACCCCTACAGAGAACCAGTGCTTCCTTCGTCAGCAGCGCCTCCCCAGACCCACGAGGATACTCACACTGCACGCCTGAG
GCTCTCCTAAGCTCCTTCTTTCATTCTGCCATTCCTCCCTCCCTTCCTTTTTTAAATGATTTTTATTACGGTGTGGTCACTTATTTAGAT
GGACATTGCTTTTCAAATAACTTAAAATAACACGTTATGTGCCATGTGGCTACTTTAGTAATATTGCCAAGAAGAGCACAGTTTTTACAC
TAGTGGCATCTCAGTGAAATTAACCAAAGATGAAGCTTTGGCTTTGCTGGTGAGATCAGAGCCCTCCTGAGCAGGCAGCGCCACTCCAGG
GTTCAGACAGGGCTGCACAGGCGGCAGAGATACAGGGTCTGAGGGCTGAGACGCCATGGGGCCGCTGCTGCTTATGTGGTTGGATTGTTT
ACAAGCCTCATTATTAAAACTGAAGGCATTTTTTTTTTCTGCTGCCTTTCCCAAAGTGGTTAGGTTTGGAAAAGAGATGATGATGGTAAT
ATTTTATTTGTGCTTTTTAAGCCATTTCCCCAAATGGGACTAGCATGCTTGTTTTCAGTATACCGTGGCCTGCCTCATGATGGTTTGGAG
ATACTGTCTGTGGATGTGAGGTGGGGACTTCATTCATTGTCCTATTTCTATCTCCACTTTGTGCCTGGAGAGCTTTCAGGGGAGGTGGAG
GAGGAGGGTCTGCCAAGCTACTGCAACATCTGTCACCCACTATACCCAGTTACTTGGGGGAGGACAGACACTGTGGTGTCATTAAAGTTG
TTTGAACCAAAGTGGCGGCTGCATCTTTGTCCCGATGCTAGCCGTGCCGGTCTCCCATCATCCGCTCGCCCTCCTTTCCCCTGGGCTGCG
CCCACTTGTCTTCCTGGATATTTGGGGGTGACTCGCCATGCTTGGCACCCTCTGCTTCCTGGTGCTGCTCTGACTCGAAGACGGGACAGT
CCCTGGTGCACATCCAGGGAAGAGGAGTGTCGGTAGTTCTTGCAGTAGGCACTTTATCAGGACCTGACCTGTTGCTGGGTGATTTTAGTC
TCTACAAACAGAAAGCGTTTCAAAGCGTCAGCTGTGGGAGCAGAGTGACCCTTTGCTGATGCTGGGGGGAGGGGATCTAAATCCTCATTT
ATCTCTTCTATGTCTCGTATTTTACTGTCACTGGAGGCTCTGTGGGCTGTCATAGTTAATTGACCATAATTAGCAATATACTTTTAAAGT
GGGAAAGCTGAATGACACTTTTAAGACAATGAACATTATCAAAACAAAATGTATAATTTCTTAATTTGAATAATAAATTAAGCGTTTAAA
TGCTATTTGTAGTCTTGATATACAGAAATAAAATAATTAGGGTTGGTCTTTTTTATTTTAGGTTGTTTTATGTTGAATGTTCTATATCTT
ATTAGTTAATTTGTATATTTTATTAGTATTTTGGAAATAGCATATCTGAGACTGAAGAGAAATTGACAATTCACTTATTTGTGGTTTTTT

>101990_101990_5_ZNF398-UBE3C_ZNF398_chr7_148864022_ENST00000483892_UBE3C_chr7_157049608_ENST00000348165_length(amino acids)=225AA_BP=125
MGTSWRASGPCWEPCCRSTGCCRGGWRTWRTCCATGTSGSCGSLQVPVAFDDVSIYFSTPEWEKLEEWQKELYKNIMKGNYESLISMDYA
INQPDVLSQIQPEGEHNTEDQAGPEESEIPTDPSEGGYSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNG

--------------------------------------------------------------
>101990_101990_6_ZNF398-UBE3C_ZNF398_chr7_148864022_ENST00000491174_UBE3C_chr7_157049608_ENST00000348165_length(transcript)=2746nt_BP=827nt
GCCTGCACGCAGCCCCGTAGAATGAGAAGGGGACGGTCAGGCCGCGGGGAAAGCACTGATCGCATTTGCCACCCAAGAGGTCTTTGGTCA
CCTCTAGGAGAGCAATTGTACTGGGCACGCTTACTAATCTGCTTACAGGAATGGAGAAAGAATGATTGGACTGATTCAAGGCCGGAGGTT
AGCTGAGCAGACATCTGAATGGGACTCCGAGTGCCTTACATCCCTGCAGCCCCTTCCTCTTCCTACACCCCCAGCAGCAAATGAGGCACA
CCTGCAGACAGCAGCTATCTCTCTGTGGACAGTGGTGGCCGCCGTGCAGGCTATAGAGAGGAAGGTGGAGATCCACAGCCGGCGACTCCT
ACACCTGGAAGGTCGGACAGGGACAGCAGAGAAGAAACTAGCCAGCTGTGAAAAGACAGTTACCGAGCTTGGGAACCAGCTGGAGGGCAA
GTGGGCCGTGCTGGGAACCCTGCTGCAGGAGTACGGGCTGCTGCAGAGGCGGCTGGAGAACTTGGAGAACCTGCTGCGCAACAGGAACTT
CTGGATCCTGCGGCTCCCTCCAGGTATTAAGGGAGATATCCCAAAGGTGCCTGTGGCATTTGATGATGTCTCCATCTACTTTTCCACTCC
AGAGTGGGAAAAATTAGAAGAATGGCAAAAGGAACTTTACAAGAATATCATGAAGGGCAACTACGAGTCTCTCATCTCCATGGATTATGC
TATAAATCAACCTGATGTCTTATCTCAGATTCAACCAGAAGGGGAACATAATACAGAGGACCAGGCAGGGCCAGAGGAAAGTGAGATTCC
CACAGACCCCAGTGAAGGAGGCTATTCTGCAGACCATCCTGTTATTAAGGTCTTCTGGAGAGTTGTGGAAGGGTTCACTGATGAAGAAAA
GCGCAAACTGCTGAAGTTTGTAACAAGCTGCTCTCGACCCCCTCTCTTGGGGTTTAAGGAGTTGTATCCCGCATTTTGTATTCACAACGG
AGGCTCCGACCTTGAGCGGCTCCCCACAGCCAGCACCTGCATGAACCTGCTGAAGCTCCCCGAGTTCTATGACGAGACACTTTTGCGAAG
TAAACTTCTCTATGCGATTGAATGTGCCGCTGGCTTTGAGCTGAGCTGAAGCTGATGCTGGGGTCAGACCCCTACAGAGAACCAGTGCTT
CCTTCGTCAGCAGCGCCTCCCCAGACCCACGAGGATACTCACACTGCACGCCTGAGGCTCTCCTAAGCTCCTTCTTTCATTCTGCCATTC
CTCCCTCCCTTCCTTTTTTAAATGATTTTTATTACGGTGTGGTCACTTATTTAGATGGACATTGCTTTTCAAATAACTTAAAATAACACG
TTATGTGCCATGTGGCTACTTTAGTAATATTGCCAAGAAGAGCACAGTTTTTACACTAGTGGCATCTCAGTGAAATTAACCAAAGATGAA
GCTTTGGCTTTGCTGGTGAGATCAGAGCCCTCCTGAGCAGGCAGCGCCACTCCAGGGTTCAGACAGGGCTGCACAGGCGGCAGAGATACA
GGGTCTGAGGGCTGAGACGCCATGGGGCCGCTGCTGCTTATGTGGTTGGATTGTTTACAAGCCTCATTATTAAAACTGAAGGCATTTTTT
TTTTCTGCTGCCTTTCCCAAAGTGGTTAGGTTTGGAAAAGAGATGATGATGGTAATATTTTATTTGTGCTTTTTAAGCCATTTCCCCAAA
TGGGACTAGCATGCTTGTTTTCAGTATACCGTGGCCTGCCTCATGATGGTTTGGAGATACTGTCTGTGGATGTGAGGTGGGGACTTCATT
CATTGTCCTATTTCTATCTCCACTTTGTGCCTGGAGAGCTTTCAGGGGAGGTGGAGGAGGAGGGTCTGCCAAGCTACTGCAACATCTGTC
ACCCACTATACCCAGTTACTTGGGGGAGGACAGACACTGTGGTGTCATTAAAGTTGTTTGAACCAAAGTGGCGGCTGCATCTTTGTCCCG
ATGCTAGCCGTGCCGGTCTCCCATCATCCGCTCGCCCTCCTTTCCCCTGGGCTGCGCCCACTTGTCTTCCTGGATATTTGGGGGTGACTC
GCCATGCTTGGCACCCTCTGCTTCCTGGTGCTGCTCTGACTCGAAGACGGGACAGTCCCTGGTGCACATCCAGGGAAGAGGAGTGTCGGT
AGTTCTTGCAGTAGGCACTTTATCAGGACCTGACCTGTTGCTGGGTGATTTTAGTCTCTACAAACAGAAAGCGTTTCAAAGCGTCAGCTG
TGGGAGCAGAGTGACCCTTTGCTGATGCTGGGGGGAGGGGATCTAAATCCTCATTTATCTCTTCTATGTCTCGTATTTTACTGTCACTGG
AGGCTCTGTGGGCTGTCATAGTTAATTGACCATAATTAGCAATATACTTTTAAAGTGGGAAAGCTGAATGACACTTTTAAGACAATGAAC
ATTATCAAAACAAAATGTATAATTTCTTAATTTGAATAATAAATTAAGCGTTTAAATGCTATTTGTAGTCTTGATATACAGAAATAAAAT
AATTAGGGTTGGTCTTTTTTATTTTAGGTTGTTTTATGTTGAATGTTCTATATCTTATTAGTTAATTTGTATATTTTATTAGTATTTTGG
AAATAGCATATCTGAGACTGAAGAGAAATTGACAATTCACTTATTTGTGGTTTTTTTCTCAGCTATTCTGAGCTTATTTATTTATTTGTA

>101990_101990_6_ZNF398-UBE3C_ZNF398_chr7_148864022_ENST00000491174_UBE3C_chr7_157049608_ENST00000348165_length(amino acids)=325AA_BP=225
MIGLIQGRRLAEQTSEWDSECLTSLQPLPLPTPPAANEAHLQTAAISLWTVVAAVQAIERKVEIHSRRLLHLEGRTGTAEKKLASCEKTV
TELGNQLEGKWAVLGTLLQEYGLLQRRLENLENLLRNRNFWILRLPPGIKGDIPKVPVAFDDVSIYFSTPEWEKLEEWQKELYKNIMKGN
YESLISMDYAINQPDVLSQIQPEGEHNTEDQAGPEESEIPTDPSEGGYSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKE

--------------------------------------------------------------
>101990_101990_7_ZNF398-UBE3C_ZNF398_chr7_148864022_ENST00000540950_UBE3C_chr7_157049608_ENST00000348165_length(transcript)=2736nt_BP=817nt
AGCCCCGTAGAATGAGAAGGGGACGGTCAGGCCGCGGGGAAAGCACTGATCGCATTTGCCACCCAAGAGGTCTTTGGTCACCTCTAGGAG
AGCAATTGTACTGGGCACGCTTACTAATCTGCTTACAGGAATGGAGAAAGAATGATTGGACTGATTCAAGGCCGGAGGTTAGCTGAGCAG
ACATCTGAATGGGACTCCGAGTGCCTTACATCCCTGCAGCCCCTTCCTCTTCCTACACCCCCAGCAGCAAATGAGGCACACCTGCAGACA
GCAGCTATCTCTCTGTGGACAGTGGTGGCCGCCGTGCAGGCTATAGAGAGGAAGGTGGAGATCCACAGCCGGCGACTCCTACACCTGGAA
GGTCGGACAGGGACAGCAGAGAAGAAACTAGCCAGCTGTGAAAAGACAGTTACCGAGCTTGGGAACCAGCTGGAGGGCAAGTGGGCCGTG
CTGGGAACCCTGCTGCAGGAGTACGGGCTGCTGCAGAGGCGGCTGGAGAACTTGGAGAACCTGCTGCGCAACAGGAACTTCTGGATCCTG
CGGCTCCCTCCAGGTATTAAGGGAGATATCCCAAAGGTGCCTGTGGCATTTGATGATGTCTCCATCTACTTTTCCACTCCAGAGTGGGAA
AAATTAGAAGAATGGCAAAAGGAACTTTACAAGAATATCATGAAGGGCAACTACGAGTCTCTCATCTCCATGGATTATGCTATAAATCAA
CCTGATGTCTTATCTCAGATTCAACCAGAAGGGGAACATAATACAGAGGACCAGGCAGGGCCAGAGGAAAGTGAGATTCCCACAGACCCC
AGTGAAGGAGGCTATTCTGCAGACCATCCTGTTATTAAGGTCTTCTGGAGAGTTGTGGAAGGGTTCACTGATGAAGAAAAGCGCAAACTG
CTGAAGTTTGTAACAAGCTGCTCTCGACCCCCTCTCTTGGGGTTTAAGGAGTTGTATCCCGCATTTTGTATTCACAACGGAGGCTCCGAC
CTTGAGCGGCTCCCCACAGCCAGCACCTGCATGAACCTGCTGAAGCTCCCCGAGTTCTATGACGAGACACTTTTGCGAAGTAAACTTCTC
TATGCGATTGAATGTGCCGCTGGCTTTGAGCTGAGCTGAAGCTGATGCTGGGGTCAGACCCCTACAGAGAACCAGTGCTTCCTTCGTCAG
CAGCGCCTCCCCAGACCCACGAGGATACTCACACTGCACGCCTGAGGCTCTCCTAAGCTCCTTCTTTCATTCTGCCATTCCTCCCTCCCT
TCCTTTTTTAAATGATTTTTATTACGGTGTGGTCACTTATTTAGATGGACATTGCTTTTCAAATAACTTAAAATAACACGTTATGTGCCA
TGTGGCTACTTTAGTAATATTGCCAAGAAGAGCACAGTTTTTACACTAGTGGCATCTCAGTGAAATTAACCAAAGATGAAGCTTTGGCTT
TGCTGGTGAGATCAGAGCCCTCCTGAGCAGGCAGCGCCACTCCAGGGTTCAGACAGGGCTGCACAGGCGGCAGAGATACAGGGTCTGAGG
GCTGAGACGCCATGGGGCCGCTGCTGCTTATGTGGTTGGATTGTTTACAAGCCTCATTATTAAAACTGAAGGCATTTTTTTTTTCTGCTG
CCTTTCCCAAAGTGGTTAGGTTTGGAAAAGAGATGATGATGGTAATATTTTATTTGTGCTTTTTAAGCCATTTCCCCAAATGGGACTAGC
ATGCTTGTTTTCAGTATACCGTGGCCTGCCTCATGATGGTTTGGAGATACTGTCTGTGGATGTGAGGTGGGGACTTCATTCATTGTCCTA
TTTCTATCTCCACTTTGTGCCTGGAGAGCTTTCAGGGGAGGTGGAGGAGGAGGGTCTGCCAAGCTACTGCAACATCTGTCACCCACTATA
CCCAGTTACTTGGGGGAGGACAGACACTGTGGTGTCATTAAAGTTGTTTGAACCAAAGTGGCGGCTGCATCTTTGTCCCGATGCTAGCCG
TGCCGGTCTCCCATCATCCGCTCGCCCTCCTTTCCCCTGGGCTGCGCCCACTTGTCTTCCTGGATATTTGGGGGTGACTCGCCATGCTTG
GCACCCTCTGCTTCCTGGTGCTGCTCTGACTCGAAGACGGGACAGTCCCTGGTGCACATCCAGGGAAGAGGAGTGTCGGTAGTTCTTGCA
GTAGGCACTTTATCAGGACCTGACCTGTTGCTGGGTGATTTTAGTCTCTACAAACAGAAAGCGTTTCAAAGCGTCAGCTGTGGGAGCAGA
GTGACCCTTTGCTGATGCTGGGGGGAGGGGATCTAAATCCTCATTTATCTCTTCTATGTCTCGTATTTTACTGTCACTGGAGGCTCTGTG
GGCTGTCATAGTTAATTGACCATAATTAGCAATATACTTTTAAAGTGGGAAAGCTGAATGACACTTTTAAGACAATGAACATTATCAAAA
CAAAATGTATAATTTCTTAATTTGAATAATAAATTAAGCGTTTAAATGCTATTTGTAGTCTTGATATACAGAAATAAAATAATTAGGGTT
GGTCTTTTTTATTTTAGGTTGTTTTATGTTGAATGTTCTATATCTTATTAGTTAATTTGTATATTTTATTAGTATTTTGGAAATAGCATA
TCTGAGACTGAAGAGAAATTGACAATTCACTTATTTGTGGTTTTTTTCTCAGCTATTCTGAGCTTATTTATTTATTTGTATGTTCTAATG

>101990_101990_7_ZNF398-UBE3C_ZNF398_chr7_148864022_ENST00000540950_UBE3C_chr7_157049608_ENST00000348165_length(amino acids)=325AA_BP=225
MIGLIQGRRLAEQTSEWDSECLTSLQPLPLPTPPAANEAHLQTAAISLWTVVAAVQAIERKVEIHSRRLLHLEGRTGTAEKKLASCEKTV
TELGNQLEGKWAVLGTLLQEYGLLQRRLENLENLLRNRNFWILRLPPGIKGDIPKVPVAFDDVSIYFSTPEWEKLEEWQKELYKNIMKGN
YESLISMDYAINQPDVLSQIQPEGEHNTEDQAGPEESEIPTDPSEGGYSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZNF398-UBE3C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF398-UBE3C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF398-UBE3C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource