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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ZNF416-ACTN4 (FusionGDB2 ID:102026)

Fusion Gene Summary for ZNF416-ACTN4

Fusion gene summary

Fusion gene information	Fusion gene name: ZNF416-ACTN4
	Fusion gene ID: 102026
		Hgene	Tgene
	Gene symbol	ZNF416	ACTN4
	Gene ID	55659	81
	Gene name	zinc finger protein 416	actinin alpha 4
	Synonyms	-	ACTININ-4\|FSGS\|FSGS1
	Cytomap	19q13.43	19q13.2
	Type of gene	protein-coding	protein-coding
	Description	zinc finger protein 416	alpha-actinin-4focal segmental glomerulosclerosis 1non-muscle alpha-actinin 4
	Modification date	20200313	20200327
	UniProtAcc	.	O43707
	Ensembl transtripts involved in fusion gene	ENST00000196489,	ENST00000390009, ENST00000497637, ENST00000252699, ENST00000424234,
Fusion gene scores	* DoF score	3 X 3 X 3=27	27 X 38 X 12=12312
	# samples	4	48
	** MAII score	log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(48/12312*10)=-4.68088692071969 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ZNF416 [Title/Abstract] AND ACTN4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ZNF416(58089425)-ACTN4(39191240), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ACTN4	GO:0033209	tumor necrosis factor-mediated signaling pathway	25411248
Tgene	ACTN4	GO:0035357	peroxisome proliferator activated receptor signaling pathway	22351778
Tgene	ACTN4	GO:0048384	retinoic acid receptor signaling pathway	22351778
Tgene	ACTN4	GO:0051272	positive regulation of cellular component movement	9508771

Fusion gene breakpoints across ZNF416 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ACTN4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-3B-A9HX-01A	ZNF416	chr19	58089425	-	ACTN4	chr19	39191240	+

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Fusion Gene ORF analysis for ZNF416-ACTN4

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000196489	ENST00000390009	ZNF416	chr19	58089425	-	ACTN4	chr19	39191240	+
5CDS-intron	ENST00000196489	ENST00000497637	ZNF416	chr19	58089425	-	ACTN4	chr19	39191240	+
In-frame	ENST00000196489	ENST00000252699	ZNF416	chr19	58089425	-	ACTN4	chr19	39191240	+
In-frame	ENST00000196489	ENST00000424234	ZNF416	chr19	58089425	-	ACTN4	chr19	39191240	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000196489

ZNF416

chr19

58089425

ENST00000252699

ACTN4

chr19

39191240

5023

298

145

2871

908

ENST00000196489

ZNF416

chr19

58089425

ENST00000424234

ACTN4

chr19

39191240

1702

298

145

1701

519

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000196489	ENST00000252699	ZNF416	chr19	58089425	-	ACTN4	chr19	39191240	+	0.008230717	0.9917693
ENST00000196489	ENST00000424234	ZNF416	chr19	58089425	-	ACTN4	chr19	39191240	+	0.006395498	0.9936045

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Fusion Genomic Features for ZNF416-ACTN4

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ZNF416	chr19	58089424	-	ACTN4	chr19	39191239	+	1.81E-06	0.9999982
ZNF416	chr19	58089424	-	ACTN4	chr19	39191239	+	1.81E-06	0.9999982

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF416-ACTN4

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:58089425/chr19:39191240)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ACTN4 O43707
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). {ECO:0000250\|UniProtKB:P57780, ECO:0000269\|PubMed:15772161, ECO:0000269\|PubMed:22351778, ECO:0000305\|PubMed:9508771}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ACTN4

chr19:58089425

chr19:39191240

ENST00000252699

778_789

912.0

Calcium binding

Tgene

ACTN4

chr19:58089425

chr19:39191240

ENST00000252699

819_830

912.0

Calcium binding

Tgene

ACTN4

chr19:58089425

chr19:39191240

ENST00000390009

778_789

693.0

Calcium binding

Tgene

ACTN4

chr19:58089425

chr19:39191240

ENST00000390009

819_830

693.0

Calcium binding

Tgene

ACTN4

chr19:58089425

chr19:39191240

ENST00000390009

19_26

693.0

Compositional bias

Poly-Gly

Tgene

ACTN4

chr19:58089425

chr19:39191240

ENST00000252699

163_269

912.0

Domain

Calponin-homology (CH) 2

Tgene

ACTN4

chr19:58089425

chr19:39191240

ENST00000252699

765_800

912.0

Domain

EF-hand 1

Tgene

ACTN4

chr19:58089425

chr19:39191240

ENST00000252699

806_841

912.0

Domain

EF-hand 2

Tgene

ACTN4

chr19:58089425

chr19:39191240

ENST00000390009

163_269

693.0

Domain

Calponin-homology (CH) 2

Tgene

ACTN4

chr19:58089425

chr19:39191240

ENST00000390009

50_154

693.0

Domain

Calponin-homology (CH) 1

Tgene

ACTN4

chr19:58089425

chr19:39191240

ENST00000390009

765_800

693.0

Domain

EF-hand 1

Tgene

ACTN4

chr19:58089425

chr19:39191240

ENST00000390009

806_841

693.0

Domain

EF-hand 2

Tgene

ACTN4

chr19:58089425

chr19:39191240

ENST00000252699

84_88

912.0

Motif

LXXLL motif

Tgene

ACTN4

chr19:58089425

chr19:39191240

ENST00000390009

84_88

693.0

Motif

LXXLL motif

Tgene

ACTN4

chr19:58089425

chr19:39191240

ENST00000252699

177_192

912.0

Region

Polyphosphoinositide (PIP2)-binding

Tgene

ACTN4

chr19:58089425

chr19:39191240

ENST00000390009

177_192

693.0

Region

Polyphosphoinositide (PIP2)-binding

Tgene

ACTN4

chr19:58089425

chr19:39191240

ENST00000390009

1_269

693.0

Region

Note=Actin-binding

Tgene

ACTN4

chr19:58089425

chr19:39191240

ENST00000252699

293_403

912.0

Repeat

Spectrin 1

Tgene

ACTN4

chr19:58089425

chr19:39191240

ENST00000252699

413_518

912.0

Repeat

Spectrin 2

Tgene

ACTN4

chr19:58089425

chr19:39191240

ENST00000252699

528_639

912.0

Repeat

Spectrin 3

Tgene

ACTN4

chr19:58089425

chr19:39191240

ENST00000252699

649_752

912.0

Repeat

Spectrin 4

Tgene

ACTN4

chr19:58089425

chr19:39191240

ENST00000390009

293_403

693.0

Repeat

Spectrin 1

Tgene

ACTN4

chr19:58089425

chr19:39191240

ENST00000390009

413_518

693.0

Repeat

Spectrin 2

Tgene

ACTN4

chr19:58089425

chr19:39191240

ENST00000390009

528_639

693.0

Repeat

Spectrin 3

Tgene

ACTN4

chr19:58089425

chr19:39191240

ENST00000390009

649_752

693.0

Repeat

Spectrin 4

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ZNF416

chr19:58089425

chr19:39191240

ENST00000196489

28_111

595.0

Domain

KRAB

Hgene

ZNF416

chr19:58089425

chr19:39191240

ENST00000196489

242_264

595.0

Zinc finger

C2H2-type 1%3B degenerate

Hgene

ZNF416

chr19:58089425

chr19:39191240

ENST00000196489

270_292

595.0

Zinc finger

C2H2-type 2

Hgene

ZNF416

chr19:58089425

chr19:39191240

ENST00000196489

298_320

595.0

Zinc finger

C2H2-type 3

Hgene

ZNF416

chr19:58089425

chr19:39191240

ENST00000196489

326_348

595.0

Zinc finger

C2H2-type 4

Hgene

ZNF416

chr19:58089425

chr19:39191240

ENST00000196489

354_376

595.0

Zinc finger

C2H2-type 5

Hgene

ZNF416

chr19:58089425

chr19:39191240

ENST00000196489

382_404

595.0

Zinc finger

C2H2-type 6

Hgene

ZNF416

chr19:58089425

chr19:39191240

ENST00000196489

410_432

595.0

Zinc finger

C2H2-type 7

Hgene

ZNF416

chr19:58089425

chr19:39191240

ENST00000196489

438_460

595.0

Zinc finger

C2H2-type 8

Hgene

ZNF416

chr19:58089425

chr19:39191240

ENST00000196489

466_488

595.0

Zinc finger

C2H2-type 9

Hgene

ZNF416

chr19:58089425

chr19:39191240

ENST00000196489

494_516

595.0

Zinc finger

C2H2-type 10

Hgene

ZNF416

chr19:58089425

chr19:39191240

ENST00000196489

522_544

595.0

Zinc finger

C2H2-type 11

Hgene

ZNF416

chr19:58089425

chr19:39191240

ENST00000196489

550_572

595.0

Zinc finger

C2H2-type 12

Tgene

ACTN4

chr19:58089425

chr19:39191240

ENST00000252699

19_26

912.0

Compositional bias

Poly-Gly

Tgene

ACTN4

chr19:58089425

chr19:39191240

ENST00000252699

50_154

912.0

Domain

Calponin-homology (CH) 1

Tgene

ACTN4

chr19:58089425

chr19:39191240

ENST00000252699

1_269

912.0

Region

Note=Actin-binding

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Fusion Gene Sequence for ZNF416-ACTN4

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>102026_102026_1_ZNF416-ACTN4_ZNF416_chr19_58089425_ENST00000196489_ACTN4_chr19_39191240_ENST00000252699_length(transcript)=5023nt_BP=298nt
TTGCATACGGTAAGGCGGGACTTCCGGCACCGCTCCGAGATGGTAATTTTGGTGGTTCTCTACCTCGGCCCACGCCGCCTGAGTTAGAAA
CGCTGCCTCCGGCACAGAGCGGGGGTCGCCCCGCTGCGCATCAGCCGGTGGGTCGCTGGCGCTGGTGGCAGCCGTGCCTGGGTTCCCGCC
CCGGGTCGCCCGCCGCTCCCGGCCCCGCTCCGCTCACAATCCGATGGCGGCGGCCGTGCTTAGGGATTCGACTTCGGTTCCCGTGACTGC
AGAAGCTAAACTTATGGGCTTTACACAGACCTTCACGGCATGGTGCAACTCCCACCTGCGGAAGGCAGGCACACAGATCGAGAACATTGA
TGAGGACTTCCGAGACGGGCTCAAGCTCATGCTGCTCCTGGAGGTCATATCAGGGGAGCGGTTACCTAAGCCGGAGCGGGGGAAGATGAG
AGTGCACAAAATCAACAATGTGAACAAAGCGCTGGACTTTATTGCCAGCAAAGGCGTCAAGCTGGTCTCCATCGGGGCAGAAGAGATTGT
GGACGGCAACGCAAAGATGACCCTGGGAATGATCTGGACCATCATCCTTAGGTTCGCCATCCAGGACATCTCCGTGGAAGAGACCTCGGC
CAAGGAAGGGCTCCTTCTCTGGTGCCAGAGAAAGACAGCCCCGTATAAGAACGTCAATGTGCAGAACTTCCACATCAGCTGGAAGGATGG
TCTTGCCTTCAATGCCCTGATCCACCGGCACAGACCAGAGCTGATTGAGTATGACAAGCTGAGGAAGGACGACCCTGTCACCAACCTGAA
CAATGCCTTCGAAGTGGCTGAGAAATACCTCGACATCCCCAAGATGCTGGATGCAGAGGACATCGTGAACACGGCCCGGCCCGACGAGAA
GGCCATAATGACCTATGTGTCCAGCTTCTACCATGCCTTTTCAGGAGCGCAGAAGGCTGAAACTGCCGCCAACCGGATCTGTAAGGTGCT
GGCTGTCAACCAAGAGAACGAGCACCTGATGGAGGACTACGAGAAGCTGGCCAGCGACCTCCTGGAGTGGATCCGGCGCACCATCCCCTG
GCTGGAGGACCGTGTGCCCCAAAAGACTATCCAGGAGATGCAGCAGAAGCTGGAGGACTTCCGCGACTACCGGCGTGTGCACAAGCCGCC
CAAGGTGCAGGAGAAGTGCCAGCTGGAGATCAACTTCAACACGCTGCAGACCAAGCTGCGCCTCAGCAACCGGCCCGCCTTCATGCCCTC
CGAGGGCAAGATGGTCTCGGACATCAACAATGGCTGGCAGCACTTGGAGCAGGCTGAGAAGGGCTACGAGGAGTGGCTGCTGAATGAGAT
CCGCAGGCTGGAGCGGCTCGACCACCTGGCAGAGAAGTTCCGGCAGAAGGCCTCCATCCACGAGGCCTGGACTGACGGGAAGGAAGCCAT
GCTGAAGCACCGGGACTACGAGACGGCCACACTATCGGACATCAAAGCCCTCATTCGCAAGCACGAGGCCTTCGAGAGCGACCTGGCTGC
GCACCAGGACCGCGTGGAGCAGATCGCCGCCATTGCCCAGGAGCTCAACGAGCTGGATTACTACGACTCCCACAATGTCAACACCCGGTG
CCAGAAGATCTGTGACCAGTGGGACGCCCTCGGCTCTCTGACACATAGTCGCAGGGAAGCCCTGGAGAAAACAGAGAAGCAGCTGGAGGC
CATCGACCAGCTGCACCTGGAATACGCCAAGCGCGCGGCCCCCTTCAACAACTGGATGGAGAGCGCCATGGAGGACCTCCAGGACATGTT
CATCGTCCATACCATCGAGGAGATTGAGGGCCTGATCTCAGCCCATGACCAGTTCAAGTCCACCCTGCCGGACGCCGATAGGGAGCGCGA
GGCCATCCTGGCCATCCACAAGGAGGCCCAGAGGATCGCTGAGAGCAACCACATCAAGCTGTCGGGCAGCAACCCCTACACCACCGTCAC
CCCGCAAATCATCAACTCCAAGTGGGAGAAGGTGCAGCAGCTGGTGCCAAAACGGGACCATGCCCTCCTGGAGGAGCAGAGCAAGCAGCA
GTCCAACGAGCACCTGCGCCGCCAGTTCGCCAGCCAGGCCAATGTTGTGGGGCCCTGGATCCAGACCAAGATGGAGGAGATCGGGCGCAT
CTCCATTGAGATGAACGGGACCCTGGAGGACCAGCTGAGCCACCTGAAGCAGTATGAACGCAGCATCGTGGACTACAAGCCCAACCTGGA
CCTGCTGGAGCAGCAGCACCAGCTCATCCAGGAGGCCCTCATCTTCGACAACAAGCACACCAACTATACCATGGAGCACATCCGCGTGGG
CTGGGAGCAGCTGCTCACCACCATTGCCCGCACCATCAACGAGGTGGAGAACCAGATCCTCACCCGCGACGCCAAGGGCATCAGCCAGGA
GCAGATGCAGGAGTTCCGGGCGTCCTTCAACCACTTCGACAAGGATCATGGCGGGGCGCTGGGGCCCGAGGAGTTCAAGGCCTGCCTCAT
CAGCCTGGGCTACGACGTGGAGAACGACCGGCAGGGTGAGGCCGAGTTCAACCGCATCATGAGCCTGGTCGACCCCAACCATAGCGGCCT
TGTGACCTTCCAAGCCTTCATCGACTTCATGTCGCGGGAGACCACCGACACGGACACGGCTGACCAGGTCATCGCTTCCTTCAAGGTCTT
AGCAGGGGACAAGAACTTCATCACAGCTGAGGAGCTGCGGAGAGAGCTGCCCCCCGACCAGGCCGAGTACTGCATCGCCCGCATGGCGCC
ATACCAGGGCCCTGACGCCGTGCCCGGTGCCCTCGACTACAAGTCCTTCTCCACGGCCTTGTATGGCGAGAGCGACCTGTGAGGCCCCAG
AGACCTGACCCAACACCCCCGACGGCCTCCAGGAGGGGCCTGGGCAGCCCCACAGTCCCATTCCTCCACTCTGTATCTATGCAAAGCACT
CTCTGCAGTCCTCCGGGGTGGGTGGGTGGGCAGGGAGGGGCTGGGGCAGGCTCTCTCCTCTCTCTCTTTGTGGGTTGGCCAGGAGGTTCC
CCCGACCAGGTTGGGGAGACTTGGGGCCAGCGCTTCTGGTCTGGTAAATATGTATGATGTGTTGTGCTTTTTTAACCAAGGAGGGGCCAG
TGGATTCCCACAGCACAACCGGTCCCTTCCATGCCCTGGGATGCCTCACCACACCCAGGTCTCTTCCTTTGCTCTGAGGTCCCTTCAAGG
CCTCCCCAATCCAGGCCAAAGCCCCATGTGCCTTGTCCAGGAACTGCCTGGGCCATGCGAGGGGCCAGCAGAGGGCGCCACCACCACCTG
ACGGCTGGGGACCCACCCAGCCCCTCTCCCCTCTCTGCTCCAGACTCACTTGCCATTGCCAGGAGATGGCCCCAACAAGCACCCCGCTTT
TGCAGCAGAGGAGCTGAGTTGGCAGACCGGGCCCCCCTGAACCGCACCCCATCCCACCAGCCCCGGCCTTGCTTTGTCTGGCCTCACGTG
TCTCAGATTTTCTAAGAACCAAAAAAAAAAAAGGAAAAAAAACACAAAACAACAAAAACCAAAAAAAAAAAAAATCACAAAAACAAAAAA
ACTATAAAAAAGAAAGAATTAAAAACTTTCAGAGAATTACTATTTACTTTATTAACTTACGGATTTATTATATAAATATATATTCACCTA
GCAACATATCTCTGCCGTCTCTCCTGCTCTCATAATGAAGACATAGCCGATTCTCTGCCCGGGCCCCTTGCTGATGCTCCTCCGGGTCTG
CGTCGGGCGTGGGTCTCTGGGGACCCTCCAGAGGTGGAGGTGGGCTGATGGCCTGGCTGCCTGGTGGTTGATGGTTTTGCTCCCCCTACC
TTTTTTTTTTGAGTTTATTCTGATTGATTTTTTTTCTTGGTTTCTGGATAAACCACCCTCTGGGGACAGGATAATAAAACATGTAATATT
TTTAAGAAGGATTCCTGCAGCATCATCTTTTTTTATTTCTCCTGTGTCTGTCCTCCACCTTCTAGGAGAGCCAGGGCAGAGCTAGCACTG
TCTTAAGCTGTCAACGTGGACTAGCTCGTGTCATCTGCTCGAGAAGGGCTGTCGCTGTTCTTGTTTCTGAGTGAGGAGTACGCAGGCCAG
AGTGGTCACCCGGCCGTGAGCAGTGAGGGCCAGAGACTAGCCCCAGACAGGTGGATGCCAGAGAGAGTGGCACCCATGCCAGGCAAGGCC
TAGGGAGGTGGTCTTGCTCAGCAACCCTGCCCTGAGCAGCAGGTGCGCCCATCCGGAGATCCTAGGAGAAGGTGGCCACCTCCATCCACT
AAGGAAGAGAAGGAAGACAGTGGCTTGAGGCAGGGAGCTCGCAGGACAGAGCCTGAGCCACCCTGTCCCTCCCACCTGGCTCACCTGTCT
GTGGGTCAGGCAGATGACCCCCTCACCCCCATCCAGGTGCTGGCTGCAGTGGCCTGTGCAGAGAGGGGCAGGGTGAGTGCCCACCAGTCC
CCGTACCCCTTCCCCCCATGCCCCACCATGCCGGGGTGGTACTCACAGAAGATGCAGGTGAGGTGGGCCACACAGGACACGAACCGCTCG
AAGTCCACACGCAGACGGCTATCCCGGTAGCGGCTGGTGAGGGTCTGGGTCAGCTGGTTGTTCAGGTGGAAGCCTAGGGGGAGGCTGCTT
CTGAGCCCAGTGGCCCACAGGGAACCCACCTTGGCATTGCATCCCCACCCCACCTCCTCAGGGAGGACATGAATGCCACAGGGTGTCACA
CCCCAACTCTGCCCCATCCCGGCAGGGTGAGTACAGGCTGATCCCTTCAATCCTCTGGGCCTGTTTCCTCATCCATCAAACGGACTAAGA
CAGCCCCGACCCCATAGGGTGTGTGAAGACAGAACGCTCAGGACAGCGTCTGACACGTGACTCGATGTGTGGGTACTGTTACTCCTTAAA

>102026_102026_1_ZNF416-ACTN4_ZNF416_chr19_58089425_ENST00000196489_ACTN4_chr19_39191240_ENST00000252699_length(amino acids)=908AA_BP=50
MALVAAVPGFPPRVARRSRPRSAHNPMAAAVLRDSTSVPVTAEAKLMGFTQTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISG
ERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNV
NVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQK
AETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTK
LRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALI
RKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNW
MESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKR
DHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNK
HTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGEAEFNR
IMSLVDPNHSGLVTFQAFIDFMSRETTDTDTADQVIASFKVLAGDKNFITAEELRRELPPDQAEYCIARMAPYQGPDAVPGALDYKSFST

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>102026_102026_2_ZNF416-ACTN4_ZNF416_chr19_58089425_ENST00000196489_ACTN4_chr19_39191240_ENST00000424234_length(transcript)=1702nt_BP=298nt
TTGCATACGGTAAGGCGGGACTTCCGGCACCGCTCCGAGATGGTAATTTTGGTGGTTCTCTACCTCGGCCCACGCCGCCTGAGTTAGAAA
CGCTGCCTCCGGCACAGAGCGGGGGTCGCCCCGCTGCGCATCAGCCGGTGGGTCGCTGGCGCTGGTGGCAGCCGTGCCTGGGTTCCCGCC
CCGGGTCGCCCGCCGCTCCCGGCCCCGCTCCGCTCACAATCCGATGGCGGCGGCCGTGCTTAGGGATTCGACTTCGGTTCCCGTGACTGC
AGAAGCTAAACTTATGGGCTTTACACAGACCTTCACGGCATGGTGCAACTCCCACCTGCGGAAGGCAGGCACACAGATCGAGAACATTGA
TGAGGACTTCCGAGACGGGCTCAAGCTCATGCTGCTCCTGGAGGTTCACGAGCTGGATTACTACGACTCCCACAATGTCAACACCCGGTG
CCAGAAGATCTGTGACCAGTGGGACGCCCTCGGCTCTCTGACACATAGTCGCAGGGAAGCCCTGGAGAAAACAGAGAAGCAGCTGGAGGC
CATCGACCAGCTGCACCTGGAATACGCCAAGCGCGCGGCCCCCTTCAACAACTGGATGGAGAGCGCCATGGAGGACCTCCAGGACATGTT
CATCGTCCATACCATCGAGGAGATTGAGGGCCTGATCTCAGCCCATGACCAGTTCAAGTCCACCCTGCCGGACGCCGATAGGGAGCGCGA
GGCCATCCTGGCCATCCACAAGGAGGCCCAGAGGATCGCTGAGAGCAACCACATCAAGCTGTCGGGCAGCAACCCCTACACCACCGTCAC
CCCGCAAATCATCAACTCCAAGTGGGAGAAGGTGCAGCAGCTGGTGCCAAAACGGGACCATGCCCTCCTGGAGGAGCAGAGCAAGCAGCA
GTCCAACGAGCACCTGCGCCGCCAGTTCGCCAGCCAGGCCAATGTTGTGGGGCCCTGGATCCAGACCAAGATGGAGGAGATCGGGCGCAT
CTCCATTGAGATGAACGGGACCCTGGAGGACCAGCTGAGCCACCTGAAGCAGTATGAACGCAGCATCGTGGACTACAAGCCCAACCTGGA
CCTGCTGGAGCAGCAGCACCAGCTCATCCAGGAGGCCCTCATCTTCGACAACAAGCACACCAACTATACCATGGAGCACATCCGCGTGGG
CTGGGAGCAGCTGCTCACCACCATTGCCCGCACCATCAACGAGGTGGAGAACCAGATCCTCACCCGCGACGCCAAGGGCATCAGCCAGGA
GCAGATGCAGGAGTTCCGGGCGTCCTTCAACCACTTCGACAAGGATCATGGCGGGGCGCTGGGGCCCGAGGAGTTCAAGGCCTGCCTCAT
CAGCCTGGGCTACGACGTGGAGAACGACCGGCAGGGTGAGGCCGAGTTCAACCGCATCATGAGCCTGGTCGACCCCAACCATAGCGGCCT
TGTGACCTTCCAAGCCTTCATCGACTTCATGTCGCGGGAGACCACCGACACGGACACGGCTGACCAGGTCATCGCTTCCTTCAAGGTCTT
AGCAGGGGACAAGAACTTCATCACAGCTGAGGAGCTGCGGAGAGAGCTGCCCCCCGACCAGGCCGAGTACTGCATCGCCCGCATGGCGCC

>102026_102026_2_ZNF416-ACTN4_ZNF416_chr19_58089425_ENST00000196489_ACTN4_chr19_39191240_ENST00000424234_length(amino acids)=519AA_BP=50
MALVAAVPGFPPRVARRSRPRSAHNPMAAAVLRDSTSVPVTAEAKLMGFTQTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVHEL
DYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQF
KSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGP
WIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQ
ILTRDAKGISQEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGEAEFNRIMSLVDPNHSGLVTFQAFIDFMSRETTDTD

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Fusion Gene PPI Analysis for ZNF416-ACTN4

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	ACTN4	chr19:58089425	chr19:39191240	ENST00000252699		0	21	108_126	54.0	912.0	VCL
Tgene	ACTN4	chr19:58089425	chr19:39191240	ENST00000390009		0	14	108_126	0	693.0	VCL
Tgene	ACTN4	chr19:58089425	chr19:39191240	ENST00000390009		0	14	12_26	0	693.0	VCL
Tgene	ACTN4	chr19:58089425	chr19:39191240	ENST00000390009		0	14	40_61	0	693.0	VCL

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	ACTN4	chr19:58089425	chr19:39191240	ENST00000252699		0	21	12_26	54.0	912.0	VCL
Tgene	ACTN4	chr19:58089425	chr19:39191240	ENST00000252699		0	21	40_61	54.0	912.0	VCL

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ZNF416-ACTN4

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ZNF416-ACTN4

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source