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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF419-SNRPD2 (FusionGDB2 ID:102040)

Fusion Gene Summary for ZNF419-SNRPD2

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF419-SNRPD2
Fusion gene ID: 102040
HgeneTgene
Gene symbol

ZNF419

SNRPD2

Gene ID

79744

6633

Gene namezinc finger protein 419small nuclear ribonucleoprotein D2 polypeptide
SynonymsZAPHIR|ZNF419ASMD2|SNRPD1|Sm-D2
Cytomap

19q13.43

19q13.32

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 419zinc finger protein 419Asmall nuclear ribonucleoprotein Sm D2small nuclear ribonucleoprotein D2 polypeptide 16.5kDasnRNP core protein D2
Modification date2020031320200322
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000221735, ENST00000347466, 
ENST00000354197, ENST00000415379, 
ENST00000424930, ENST00000426954, 
ENST00000442920, ENST00000518999, 
ENST00000520540, 		ENST00000391932, 
ENST00000585392, ENST00000587367, 
ENST00000588301, ENST00000588599, 
ENST00000590212, ENST00000587579, 
ENST00000342669, 
Fusion gene scores* DoF score3 X 2 X 3=1811 X 10 X 4=440
# samples 312
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(12/440*10)=-1.87446911791614
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF419 [Title/Abstract] AND SNRPD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF419(58002965)-SNRPD2(46190985), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSNRPD2

GO:0000387

spliceosomal snRNP assembly

18984161

TgeneSNRPD2

GO:0000398

mRNA splicing, via spliceosome

28076346


check buttonFusion gene breakpoints across ZNF419 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SNRPD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-32-1970-01AZNF419chr19

58002965

+SNRPD2chr19

46190985

-
ChimerDB4GBMTCGA-32-1970ZNF419chr19

58002965

+SNRPD2chr19

46190985

-


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Fusion Gene ORF analysis for ZNF419-SNRPD2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000221735ENST00000391932ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000221735ENST00000585392ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000221735ENST00000587367ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000221735ENST00000588301ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000221735ENST00000588599ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000221735ENST00000590212ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000347466ENST00000391932ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000347466ENST00000585392ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000347466ENST00000587367ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000347466ENST00000588301ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000347466ENST00000588599ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000347466ENST00000590212ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000354197ENST00000391932ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000354197ENST00000585392ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000354197ENST00000587367ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000354197ENST00000588301ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000354197ENST00000588599ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000354197ENST00000590212ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000415379ENST00000391932ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000415379ENST00000585392ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000415379ENST00000587367ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000415379ENST00000588301ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000415379ENST00000588599ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000415379ENST00000590212ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000424930ENST00000391932ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000424930ENST00000585392ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000424930ENST00000587367ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000424930ENST00000588301ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000424930ENST00000588599ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000424930ENST00000590212ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000426954ENST00000391932ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000426954ENST00000585392ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000426954ENST00000587367ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000426954ENST00000588301ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000426954ENST00000588599ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000426954ENST00000590212ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000442920ENST00000391932ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000442920ENST00000585392ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000442920ENST00000587367ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000442920ENST00000588301ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000442920ENST00000588599ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000442920ENST00000590212ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000518999ENST00000391932ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000518999ENST00000585392ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000518999ENST00000587367ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000518999ENST00000588301ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000518999ENST00000588599ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000518999ENST00000590212ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000520540ENST00000391932ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000520540ENST00000585392ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000520540ENST00000587367ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000520540ENST00000588301ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000520540ENST00000588599ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-5UTRENST00000520540ENST00000590212ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-intronENST00000221735ENST00000587579ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-intronENST00000347466ENST00000587579ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-intronENST00000354197ENST00000587579ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-intronENST00000415379ENST00000587579ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-intronENST00000424930ENST00000587579ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-intronENST00000426954ENST00000587579ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-intronENST00000442920ENST00000587579ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-intronENST00000518999ENST00000587579ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
5CDS-intronENST00000520540ENST00000587579ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
In-frameENST00000221735ENST00000342669ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
In-frameENST00000347466ENST00000342669ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
In-frameENST00000354197ENST00000342669ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
In-frameENST00000415379ENST00000342669ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
In-frameENST00000424930ENST00000342669ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
In-frameENST00000426954ENST00000342669ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
In-frameENST00000442920ENST00000342669ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
In-frameENST00000518999ENST00000342669ZNF419chr19

58002965

+SNRPD2chr19

46190985

-
In-frameENST00000520540ENST00000342669ZNF419chr19

58002965

+SNRPD2chr19

46190985

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000354197ZNF419chr1958002965+ENST00000342669SNRPD2chr1946190985-67740313243199
ENST00000426954ZNF419chr1958002965+ENST00000342669SNRPD2chr1946190985-67740313243199
ENST00000520540ZNF419chr1958002965+ENST00000342669SNRPD2chr1946190985-67039612542499
ENST00000442920ZNF419chr1958002965+ENST00000342669SNRPD2chr1946190985-66739312542198
ENST00000424930ZNF419chr1958002965+ENST00000342669SNRPD2chr1946190985-705431121459112
ENST00000347466ZNF419chr1958002965+ENST00000342669SNRPD2chr1946190985-686412102440112
ENST00000415379ZNF419chr1958002965+ENST00000342669SNRPD2chr1946190985-6353619338998
ENST00000221735ZNF419chr1958002965+ENST00000342669SNRPD2chr1946190985-65938578413111
ENST00000518999ZNF419chr1958002965+ENST00000342669SNRPD2chr1946190985-65638272410112

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000354197ENST00000342669ZNF419chr1958002965+SNRPD2chr1946190985-0.12852260.8714774
ENST00000426954ENST00000342669ZNF419chr1958002965+SNRPD2chr1946190985-0.12852260.8714774
ENST00000520540ENST00000342669ZNF419chr1958002965+SNRPD2chr1946190985-0.12794710.87205285
ENST00000442920ENST00000342669ZNF419chr1958002965+SNRPD2chr1946190985-0.190862250.80913776
ENST00000424930ENST00000342669ZNF419chr1958002965+SNRPD2chr1946190985-0.0513353830.94866467
ENST00000347466ENST00000342669ZNF419chr1958002965+SNRPD2chr1946190985-0.077715670.92228436
ENST00000415379ENST00000342669ZNF419chr1958002965+SNRPD2chr1946190985-0.154127120.84587294
ENST00000221735ENST00000342669ZNF419chr1958002965+SNRPD2chr1946190985-0.0459728130.9540271
ENST00000518999ENST00000342669ZNF419chr1958002965+SNRPD2chr1946190985-0.0450855270.9549145

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Fusion Genomic Features for ZNF419-SNRPD2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF419-SNRPD2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:58002965/chr19:46190985)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF419chr19:58002965chr19:46190985ENST00000221735+3527_9866511.0DomainKRAB
HgeneZNF419chr19:58002965chr19:46190985ENST00000347466+3427_9867479.0DomainKRAB
HgeneZNF419chr19:58002965chr19:46190985ENST00000415379+2327_9853465.0DomainKRAB
HgeneZNF419chr19:58002965chr19:46190985ENST00000424930+3527_9867512.0DomainKRAB
HgeneZNF419chr19:58002965chr19:46190985ENST00000426954+2427_9854499.0DomainKRAB
HgeneZNF419chr19:58002965chr19:46190985ENST00000442920+2427_9853498.0DomainKRAB
HgeneZNF419chr19:58002965chr19:46190985ENST00000221735+35203_22566511.0Zinc fingerC2H2-type 1
HgeneZNF419chr19:58002965chr19:46190985ENST00000221735+35231_25366511.0Zinc fingerC2H2-type 2
HgeneZNF419chr19:58002965chr19:46190985ENST00000221735+35259_28166511.0Zinc fingerC2H2-type 3
HgeneZNF419chr19:58002965chr19:46190985ENST00000221735+35287_30966511.0Zinc fingerC2H2-type 4
HgeneZNF419chr19:58002965chr19:46190985ENST00000221735+35315_33766511.0Zinc fingerC2H2-type 5
HgeneZNF419chr19:58002965chr19:46190985ENST00000221735+35343_36566511.0Zinc fingerC2H2-type 6
HgeneZNF419chr19:58002965chr19:46190985ENST00000221735+35371_39366511.0Zinc fingerC2H2-type 7
HgeneZNF419chr19:58002965chr19:46190985ENST00000221735+35399_42166511.0Zinc fingerC2H2-type 8
HgeneZNF419chr19:58002965chr19:46190985ENST00000221735+35427_44966511.0Zinc fingerC2H2-type 9
HgeneZNF419chr19:58002965chr19:46190985ENST00000221735+35455_47766511.0Zinc fingerC2H2-type 10
HgeneZNF419chr19:58002965chr19:46190985ENST00000221735+35483_50566511.0Zinc fingerC2H2-type 11
HgeneZNF419chr19:58002965chr19:46190985ENST00000347466+34203_22567479.0Zinc fingerC2H2-type 1
HgeneZNF419chr19:58002965chr19:46190985ENST00000347466+34231_25367479.0Zinc fingerC2H2-type 2
HgeneZNF419chr19:58002965chr19:46190985ENST00000347466+34259_28167479.0Zinc fingerC2H2-type 3
HgeneZNF419chr19:58002965chr19:46190985ENST00000347466+34287_30967479.0Zinc fingerC2H2-type 4
HgeneZNF419chr19:58002965chr19:46190985ENST00000347466+34315_33767479.0Zinc fingerC2H2-type 5
HgeneZNF419chr19:58002965chr19:46190985ENST00000347466+34343_36567479.0Zinc fingerC2H2-type 6
HgeneZNF419chr19:58002965chr19:46190985ENST00000347466+34371_39367479.0Zinc fingerC2H2-type 7
HgeneZNF419chr19:58002965chr19:46190985ENST00000347466+34399_42167479.0Zinc fingerC2H2-type 8
HgeneZNF419chr19:58002965chr19:46190985ENST00000347466+34427_44967479.0Zinc fingerC2H2-type 9
HgeneZNF419chr19:58002965chr19:46190985ENST00000347466+34455_47767479.0Zinc fingerC2H2-type 10
HgeneZNF419chr19:58002965chr19:46190985ENST00000347466+34483_50567479.0Zinc fingerC2H2-type 11
HgeneZNF419chr19:58002965chr19:46190985ENST00000415379+23203_22553465.0Zinc fingerC2H2-type 1
HgeneZNF419chr19:58002965chr19:46190985ENST00000415379+23231_25353465.0Zinc fingerC2H2-type 2
HgeneZNF419chr19:58002965chr19:46190985ENST00000415379+23259_28153465.0Zinc fingerC2H2-type 3
HgeneZNF419chr19:58002965chr19:46190985ENST00000415379+23287_30953465.0Zinc fingerC2H2-type 4
HgeneZNF419chr19:58002965chr19:46190985ENST00000415379+23315_33753465.0Zinc fingerC2H2-type 5
HgeneZNF419chr19:58002965chr19:46190985ENST00000415379+23343_36553465.0Zinc fingerC2H2-type 6
HgeneZNF419chr19:58002965chr19:46190985ENST00000415379+23371_39353465.0Zinc fingerC2H2-type 7
HgeneZNF419chr19:58002965chr19:46190985ENST00000415379+23399_42153465.0Zinc fingerC2H2-type 8
HgeneZNF419chr19:58002965chr19:46190985ENST00000415379+23427_44953465.0Zinc fingerC2H2-type 9
HgeneZNF419chr19:58002965chr19:46190985ENST00000415379+23455_47753465.0Zinc fingerC2H2-type 10
HgeneZNF419chr19:58002965chr19:46190985ENST00000415379+23483_50553465.0Zinc fingerC2H2-type 11
HgeneZNF419chr19:58002965chr19:46190985ENST00000424930+35203_22567512.0Zinc fingerC2H2-type 1
HgeneZNF419chr19:58002965chr19:46190985ENST00000424930+35231_25367512.0Zinc fingerC2H2-type 2
HgeneZNF419chr19:58002965chr19:46190985ENST00000424930+35259_28167512.0Zinc fingerC2H2-type 3
HgeneZNF419chr19:58002965chr19:46190985ENST00000424930+35287_30967512.0Zinc fingerC2H2-type 4
HgeneZNF419chr19:58002965chr19:46190985ENST00000424930+35315_33767512.0Zinc fingerC2H2-type 5
HgeneZNF419chr19:58002965chr19:46190985ENST00000424930+35343_36567512.0Zinc fingerC2H2-type 6
HgeneZNF419chr19:58002965chr19:46190985ENST00000424930+35371_39367512.0Zinc fingerC2H2-type 7
HgeneZNF419chr19:58002965chr19:46190985ENST00000424930+35399_42167512.0Zinc fingerC2H2-type 8
HgeneZNF419chr19:58002965chr19:46190985ENST00000424930+35427_44967512.0Zinc fingerC2H2-type 9
HgeneZNF419chr19:58002965chr19:46190985ENST00000424930+35455_47767512.0Zinc fingerC2H2-type 10
HgeneZNF419chr19:58002965chr19:46190985ENST00000424930+35483_50567512.0Zinc fingerC2H2-type 11
HgeneZNF419chr19:58002965chr19:46190985ENST00000426954+24203_22554499.0Zinc fingerC2H2-type 1
HgeneZNF419chr19:58002965chr19:46190985ENST00000426954+24231_25354499.0Zinc fingerC2H2-type 2
HgeneZNF419chr19:58002965chr19:46190985ENST00000426954+24259_28154499.0Zinc fingerC2H2-type 3
HgeneZNF419chr19:58002965chr19:46190985ENST00000426954+24287_30954499.0Zinc fingerC2H2-type 4
HgeneZNF419chr19:58002965chr19:46190985ENST00000426954+24315_33754499.0Zinc fingerC2H2-type 5
HgeneZNF419chr19:58002965chr19:46190985ENST00000426954+24343_36554499.0Zinc fingerC2H2-type 6
HgeneZNF419chr19:58002965chr19:46190985ENST00000426954+24371_39354499.0Zinc fingerC2H2-type 7
HgeneZNF419chr19:58002965chr19:46190985ENST00000426954+24399_42154499.0Zinc fingerC2H2-type 8
HgeneZNF419chr19:58002965chr19:46190985ENST00000426954+24427_44954499.0Zinc fingerC2H2-type 9
HgeneZNF419chr19:58002965chr19:46190985ENST00000426954+24455_47754499.0Zinc fingerC2H2-type 10
HgeneZNF419chr19:58002965chr19:46190985ENST00000426954+24483_50554499.0Zinc fingerC2H2-type 11
HgeneZNF419chr19:58002965chr19:46190985ENST00000442920+24203_22553498.0Zinc fingerC2H2-type 1
HgeneZNF419chr19:58002965chr19:46190985ENST00000442920+24231_25353498.0Zinc fingerC2H2-type 2
HgeneZNF419chr19:58002965chr19:46190985ENST00000442920+24259_28153498.0Zinc fingerC2H2-type 3
HgeneZNF419chr19:58002965chr19:46190985ENST00000442920+24287_30953498.0Zinc fingerC2H2-type 4
HgeneZNF419chr19:58002965chr19:46190985ENST00000442920+24315_33753498.0Zinc fingerC2H2-type 5
HgeneZNF419chr19:58002965chr19:46190985ENST00000442920+24343_36553498.0Zinc fingerC2H2-type 6
HgeneZNF419chr19:58002965chr19:46190985ENST00000442920+24371_39353498.0Zinc fingerC2H2-type 7
HgeneZNF419chr19:58002965chr19:46190985ENST00000442920+24399_42153498.0Zinc fingerC2H2-type 8
HgeneZNF419chr19:58002965chr19:46190985ENST00000442920+24427_44953498.0Zinc fingerC2H2-type 9
HgeneZNF419chr19:58002965chr19:46190985ENST00000442920+24455_47753498.0Zinc fingerC2H2-type 10
HgeneZNF419chr19:58002965chr19:46190985ENST00000442920+24483_50553498.0Zinc fingerC2H2-type 11


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Fusion Gene Sequence for ZNF419-SNRPD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>102040_102040_1_ZNF419-SNRPD2_ZNF419_chr19_58002965_ENST00000221735_SNRPD2_chr19_46190985_ENST00000342669_length(transcript)=659nt_BP=385nt
GACTCAGGTGAACTAACCTGCGAGAAGCTGGTTGTGCGCTGAGGCGACCAGCGCCGGAAGGCACGGTGGCGACTCACGCTGTTCTCGCCG
CTCAGAGGCGGGTCTGAGGCTCGGTGGCGGCGCCCAGGGTGGCCCGGGCCCTTTCCTCGGTCATTGTCTCCCCTCCAGCTCTACTCACAG
GCTCCGATGGCGGCGGCCGCCCTGAGGGACCCCGCTCAGGTTCCTGTGGCTGCAGACTTGCTTACAGACCATGAGGAGGGCTATGTGACC
TTTGAGGATGTGGCTGTCTACTTCTCCCAGGAGGAATGGAGATTGCTTGATGACGCTCAGAGGCTCCTCTACCGCAATGTGATGCTGGAG
AACTTTACACTTCTGGCCTCTCTGGGCACTGCAACATGGTGCTGGAGAACGTGAAGGAGATGTGGACTGAGGTACCCAAGAGTGGCAAGG
GCAAGAAGAAGTCCAAGCCAGTCAACAAAGACCGCTACATCTCCAAGATGTTCCTGCGCGGGGACTCAGTCATCGTGGTCCTGCGGAACC
CGCTCATCGCCGGCAAGTAGGGGCCGCCTGTCTGTTGACAGAACTCACTCCTCTGTCCTATGAAGACCGCTGCCATTGGTGTTGAGAATA

>102040_102040_1_ZNF419-SNRPD2_ZNF419_chr19_58002965_ENST00000221735_SNRPD2_chr19_46190985_ENST00000342669_length(amino acids)=111AA_BP=
MFSPLRGGSEARWRRPGWPGPFPRSLSPLQLYSQAPMAAAALRDPAQVPVAADLLTDHEEGYVTFEDVAVYFSQEEWRLLDDAQRLLYRN

--------------------------------------------------------------
>102040_102040_2_ZNF419-SNRPD2_ZNF419_chr19_58002965_ENST00000347466_SNRPD2_chr19_46190985_ENST00000342669_length(transcript)=686nt_BP=412nt
GTCTCGTTTGGTATTCACTTTCGCGACTCAGGTGAACTAACCTGCGAGAAGCTGGTTGTGCGCTGAGGCGACCAGCGCCGGAAGGCACGG
TGGCGACTCACGCTGTTCTCGCCGCTCAGAGGCGGGTCTGAGGCTCGGTGGCGGCGCCCAGGGTGGCCCGGGCCCTTTCCTCGGTCATTG
TCTCCCCTCCAGCTCTACTCACAGGCTCCGATGGCGGCGGCCGCCCTGAGGGACCCCGCTCAGGTTCCTGTGGCTGCAGACTTGCTTACA
GACCATGAGGAGCAGGGCTATGTGACCTTTGAGGATGTGGCTGTCTACTTCTCCCAGGAGGAATGGAGATTGCTTGATGACGCTCAGAGG
CTCCTCTACCGCAATGTGATGCTGGAGAACTTTACACTTCTGGCCTCTCTGGGCACTGCAACATGGTGCTGGAGAACGTGAAGGAGATGT
GGACTGAGGTACCCAAGAGTGGCAAGGGCAAGAAGAAGTCCAAGCCAGTCAACAAAGACCGCTACATCTCCAAGATGTTCCTGCGCGGGG
ACTCAGTCATCGTGGTCCTGCGGAACCCGCTCATCGCCGGCAAGTAGGGGCCGCCTGTCTGTTGACAGAACTCACTCCTCTGTCCTATGA

>102040_102040_2_ZNF419-SNRPD2_ZNF419_chr19_58002965_ENST00000347466_SNRPD2_chr19_46190985_ENST00000342669_length(amino acids)=112AA_BP=
MFSPLRGGSEARWRRPGWPGPFPRSLSPLQLYSQAPMAAAALRDPAQVPVAADLLTDHEEQGYVTFEDVAVYFSQEEWRLLDDAQRLLYR

--------------------------------------------------------------
>102040_102040_3_ZNF419-SNRPD2_ZNF419_chr19_58002965_ENST00000354197_SNRPD2_chr19_46190985_ENST00000342669_length(transcript)=677nt_BP=403nt
GTGCGACACGCAATGGGCGGGACTTCCGGCGTCTCGTTTGGTATTCACTTTCGCGACTCAGGTGAACTAACCTGCGAGAAGCTGGTTGTG
CGCTGAGGCGACCAGCGCCGGAAGGCACGGTGGCGACTCACGCTGTTCTCGCCGCTCAGAGGCGGGTCTGAGGCTCGGTGGCGGCGCCCA
GGGTGGCCCGGGCCCTTTCCTCGGTCATTGTCTCCCCTCCAGCTCTACTCACAGGCTCCGATGGCGGCGGCCGCCCTGAGGGACCCCGCT
CAGCAGGGCTATGTGACCTTTGAGGATGTGGCTGTCTACTTCTCCCAGGAGGAATGGAGATTGCTTGATGACGCTCAGAGGCTCCTCTAC
CGCAATGTGATGCTGGAGAACTTTACACTTCTGGCCTCTCTGGGCACTGCAACATGGTGCTGGAGAACGTGAAGGAGATGTGGACTGAGG
TACCCAAGAGTGGCAAGGGCAAGAAGAAGTCCAAGCCAGTCAACAAAGACCGCTACATCTCCAAGATGTTCCTGCGCGGGGACTCAGTCA
TCGTGGTCCTGCGGAACCCGCTCATCGCCGGCAAGTAGGGGCCGCCTGTCTGTTGACAGAACTCACTCCTCTGTCCTATGAAGACCGCTG

>102040_102040_3_ZNF419-SNRPD2_ZNF419_chr19_58002965_ENST00000354197_SNRPD2_chr19_46190985_ENST00000342669_length(amino acids)=99AA_BP=
MFSPLRGGSEARWRRPGWPGPFPRSLSPLQLYSQAPMAAAALRDPAQQGYVTFEDVAVYFSQEEWRLLDDAQRLLYRNVMLENFTLLASL

--------------------------------------------------------------
>102040_102040_4_ZNF419-SNRPD2_ZNF419_chr19_58002965_ENST00000415379_SNRPD2_chr19_46190985_ENST00000342669_length(transcript)=635nt_BP=361nt
GGTATTCACTTTCGCGACTCAGGTGAACTAACCTGCGAGAAGCTGGTTGTGCGCTGAGGCGACCAGCGCCGGAAGGCACGGTGGCGACTC
ACGCTGTTCTCGCCGCTCAGAGGCGGGTCTGAGGCTCGGTGGCGGCGCCCAGGGTGGCCCGGGCCCTTTCCTCGGTCATTGTCTCCCCTC
CAGCTCTACTCACAGGCTCCGATGGCGGCGGCCGCCCTGAGGGACCCCGCTCAGGGCTATGTGACCTTTGAGGATGTGGCTGTCTACTTC
TCCCAGGAGGAATGGAGATTGCTTGATGACGCTCAGAGGCTCCTCTACCGCAATGTGATGCTGGAGAACTTTACACTTCTGGCCTCTCTG
GGCACTGCAACATGGTGCTGGAGAACGTGAAGGAGATGTGGACTGAGGTACCCAAGAGTGGCAAGGGCAAGAAGAAGTCCAAGCCAGTCA
ACAAAGACCGCTACATCTCCAAGATGTTCCTGCGCGGGGACTCAGTCATCGTGGTCCTGCGGAACCCGCTCATCGCCGGCAAGTAGGGGC
CGCCTGTCTGTTGACAGAACTCACTCCTCTGTCCTATGAAGACCGCTGCCATTGGTGTTGAGAATAATAAAGCTCTGTGTTTTTTTCTAG

>102040_102040_4_ZNF419-SNRPD2_ZNF419_chr19_58002965_ENST00000415379_SNRPD2_chr19_46190985_ENST00000342669_length(amino acids)=98AA_BP=
MFSPLRGGSEARWRRPGWPGPFPRSLSPLQLYSQAPMAAAALRDPAQGYVTFEDVAVYFSQEEWRLLDDAQRLLYRNVMLENFTLLASLG

--------------------------------------------------------------
>102040_102040_5_ZNF419-SNRPD2_ZNF419_chr19_58002965_ENST00000424930_SNRPD2_chr19_46190985_ENST00000342669_length(transcript)=705nt_BP=431nt
AATGGGCGGGACTTCCGGCGTCTCGTTTGGTATTCACTTTCGCGACTCAGGTGAACTAACCTGCGAGAAGCTGGTTGTGCGCTGAGGCGA
CCAGCGCCGGAAGGCACGGTGGCGACTCACGCTGTTCTCGCCGCTCAGAGGCGGGTCTGAGGCTCGGTGGCGGCGCCCAGGGTGGCCCGG
GCCCTTTCCTCGGTCATTGTCTCCCCTCCAGCTCTACTCACAGGCTCCGATGGCGGCGGCCGCCCTGAGGGACCCCGCTCAGGTTCCTGT
GGCTGCAGACTTGCTTACAGACCATGAGGAGCAGGGCTATGTGACCTTTGAGGATGTGGCTGTCTACTTCTCCCAGGAGGAATGGAGATT
GCTTGATGACGCTCAGAGGCTCCTCTACCGCAATGTGATGCTGGAGAACTTTACACTTCTGGCCTCTCTGGGCACTGCAACATGGTGCTG
GAGAACGTGAAGGAGATGTGGACTGAGGTACCCAAGAGTGGCAAGGGCAAGAAGAAGTCCAAGCCAGTCAACAAAGACCGCTACATCTCC
AAGATGTTCCTGCGCGGGGACTCAGTCATCGTGGTCCTGCGGAACCCGCTCATCGCCGGCAAGTAGGGGCCGCCTGTCTGTTGACAGAAC

>102040_102040_5_ZNF419-SNRPD2_ZNF419_chr19_58002965_ENST00000424930_SNRPD2_chr19_46190985_ENST00000342669_length(amino acids)=112AA_BP=
MFSPLRGGSEARWRRPGWPGPFPRSLSPLQLYSQAPMAAAALRDPAQVPVAADLLTDHEEQGYVTFEDVAVYFSQEEWRLLDDAQRLLYR

--------------------------------------------------------------
>102040_102040_6_ZNF419-SNRPD2_ZNF419_chr19_58002965_ENST00000426954_SNRPD2_chr19_46190985_ENST00000342669_length(transcript)=677nt_BP=403nt
GTGCGACACGCAATGGGCGGGACTTCCGGCGTCTCGTTTGGTATTCACTTTCGCGACTCAGGTGAACTAACCTGCGAGAAGCTGGTTGTG
CGCTGAGGCGACCAGCGCCGGAAGGCACGGTGGCGACTCACGCTGTTCTCGCCGCTCAGAGGCGGGTCTGAGGCTCGGTGGCGGCGCCCA
GGGTGGCCCGGGCCCTTTCCTCGGTCATTGTCTCCCCTCCAGCTCTACTCACAGGCTCCGATGGCGGCGGCCGCCCTGAGGGACCCCGCT
CAGCAGGGCTATGTGACCTTTGAGGATGTGGCTGTCTACTTCTCCCAGGAGGAATGGAGATTGCTTGATGACGCTCAGAGGCTCCTCTAC
CGCAATGTGATGCTGGAGAACTTTACACTTCTGGCCTCTCTGGGCACTGCAACATGGTGCTGGAGAACGTGAAGGAGATGTGGACTGAGG
TACCCAAGAGTGGCAAGGGCAAGAAGAAGTCCAAGCCAGTCAACAAAGACCGCTACATCTCCAAGATGTTCCTGCGCGGGGACTCAGTCA
TCGTGGTCCTGCGGAACCCGCTCATCGCCGGCAAGTAGGGGCCGCCTGTCTGTTGACAGAACTCACTCCTCTGTCCTATGAAGACCGCTG

>102040_102040_6_ZNF419-SNRPD2_ZNF419_chr19_58002965_ENST00000426954_SNRPD2_chr19_46190985_ENST00000342669_length(amino acids)=99AA_BP=
MFSPLRGGSEARWRRPGWPGPFPRSLSPLQLYSQAPMAAAALRDPAQQGYVTFEDVAVYFSQEEWRLLDDAQRLLYRNVMLENFTLLASL

--------------------------------------------------------------
>102040_102040_7_ZNF419-SNRPD2_ZNF419_chr19_58002965_ENST00000442920_SNRPD2_chr19_46190985_ENST00000342669_length(transcript)=667nt_BP=393nt
ACGCAATGGGCGGGACTTCCGGCGTCTCGTTTGGTATTCACTTTCGCGACTCAGGTGAACTAACCTGCGAGAAGCTGGTTGTGCGCTGAG
GCGACCAGCGCCGGAAGGCACGGTGGCGACTCACGCTGTTCTCGCCGCTCAGAGGCGGGTCTGAGGCTCGGTGGCGGCGCCCAGGGTGGC
CCGGGCCCTTTCCTCGGTCATTGTCTCCCCTCCAGCTCTACTCACAGGCTCCGATGGCGGCGGCCGCCCTGAGGGACCCCGCTCAGGGCT
ATGTGACCTTTGAGGATGTGGCTGTCTACTTCTCCCAGGAGGAATGGAGATTGCTTGATGACGCTCAGAGGCTCCTCTACCGCAATGTGA
TGCTGGAGAACTTTACACTTCTGGCCTCTCTGGGCACTGCAACATGGTGCTGGAGAACGTGAAGGAGATGTGGACTGAGGTACCCAAGAG
TGGCAAGGGCAAGAAGAAGTCCAAGCCAGTCAACAAAGACCGCTACATCTCCAAGATGTTCCTGCGCGGGGACTCAGTCATCGTGGTCCT
GCGGAACCCGCTCATCGCCGGCAAGTAGGGGCCGCCTGTCTGTTGACAGAACTCACTCCTCTGTCCTATGAAGACCGCTGCCATTGGTGT

>102040_102040_7_ZNF419-SNRPD2_ZNF419_chr19_58002965_ENST00000442920_SNRPD2_chr19_46190985_ENST00000342669_length(amino acids)=98AA_BP=
MFSPLRGGSEARWRRPGWPGPFPRSLSPLQLYSQAPMAAAALRDPAQGYVTFEDVAVYFSQEEWRLLDDAQRLLYRNVMLENFTLLASLG

--------------------------------------------------------------
>102040_102040_8_ZNF419-SNRPD2_ZNF419_chr19_58002965_ENST00000518999_SNRPD2_chr19_46190985_ENST00000342669_length(transcript)=656nt_BP=382nt
GGTGAACTAACCTGCGAGAAGCTGGTTGTGCGCTGAGGCGACCAGCGCCGGAAGGCACGGTGGCGACTCACGCTGTTCTCGCCGCTCAGA
GGCGGGTCTGAGGCTCGGTGGCGGCGCCCAGGGTGGCCCGGGCCCTTTCCTCGGTCATTGTCTCCCCTCCAGCTCTACTCACAGGCTCCG
ATGGCGGCGGCCGCCCTGAGGGACCCCGCTCAGGTTCCTGTGGCTGCAGACTTGCTTACAGACCATGAGGAGCAGGGCTATGTGACCTTT
GAGGATGTGGCTGTCTACTTCTCCCAGGAGGAATGGAGATTGCTTGATGACGCTCAGAGGCTCCTCTACCGCAATGTGATGCTGGAGAAC
TTTACACTTCTGGCCTCTCTGGGCACTGCAACATGGTGCTGGAGAACGTGAAGGAGATGTGGACTGAGGTACCCAAGAGTGGCAAGGGCA
AGAAGAAGTCCAAGCCAGTCAACAAAGACCGCTACATCTCCAAGATGTTCCTGCGCGGGGACTCAGTCATCGTGGTCCTGCGGAACCCGC
TCATCGCCGGCAAGTAGGGGCCGCCTGTCTGTTGACAGAACTCACTCCTCTGTCCTATGAAGACCGCTGCCATTGGTGTTGAGAATAATA

>102040_102040_8_ZNF419-SNRPD2_ZNF419_chr19_58002965_ENST00000518999_SNRPD2_chr19_46190985_ENST00000342669_length(amino acids)=112AA_BP=
MFSPLRGGSEARWRRPGWPGPFPRSLSPLQLYSQAPMAAAALRDPAQVPVAADLLTDHEEQGYVTFEDVAVYFSQEEWRLLDDAQRLLYR

--------------------------------------------------------------
>102040_102040_9_ZNF419-SNRPD2_ZNF419_chr19_58002965_ENST00000520540_SNRPD2_chr19_46190985_ENST00000342669_length(transcript)=670nt_BP=396nt
ACGCAATGGGCGGGACTTCCGGCGTCTCGTTTGGTATTCACTTTCGCGACTCAGGTGAACTAACCTGCGAGAAGCTGGTTGTGCGCTGAG
GCGACCAGCGCCGGAAGGCACGGTGGCGACTCACGCTGTTCTCGCCGCTCAGAGGCGGGTCTGAGGCTCGGTGGCGGCGCCCAGGGTGGC
CCGGGCCCTTTCCTCGGTCATTGTCTCCCCTCCAGCTCTACTCACAGGCTCCGATGGCGGCGGCCGCCCTGAGGGACCCCGCTCAGCAGG
GCTATGTGACCTTTGAGGATGTGGCTGTCTACTTCTCCCAGGAGGAATGGAGATTGCTTGATGACGCTCAGAGGCTCCTCTACCGCAATG
TGATGCTGGAGAACTTTACACTTCTGGCCTCTCTGGGCACTGCAACATGGTGCTGGAGAACGTGAAGGAGATGTGGACTGAGGTACCCAA
GAGTGGCAAGGGCAAGAAGAAGTCCAAGCCAGTCAACAAAGACCGCTACATCTCCAAGATGTTCCTGCGCGGGGACTCAGTCATCGTGGT
CCTGCGGAACCCGCTCATCGCCGGCAAGTAGGGGCCGCCTGTCTGTTGACAGAACTCACTCCTCTGTCCTATGAAGACCGCTGCCATTGG

>102040_102040_9_ZNF419-SNRPD2_ZNF419_chr19_58002965_ENST00000520540_SNRPD2_chr19_46190985_ENST00000342669_length(amino acids)=99AA_BP=
MFSPLRGGSEARWRRPGWPGPFPRSLSPLQLYSQAPMAAAALRDPAQQGYVTFEDVAVYFSQEEWRLLDDAQRLLYRNVMLENFTLLASL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZNF419-SNRPD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF419-SNRPD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF419-SNRPD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource