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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF430-KCNIP4 (FusionGDB2 ID:102082)

Fusion Gene Summary for ZNF430-KCNIP4

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF430-KCNIP4
Fusion gene ID: 102082
HgeneTgene
Gene symbol

ZNF430

KCNIP4

Gene ID

80264

80333

Gene namezinc finger protein 430potassium voltage-gated channel interacting protein 4
Synonyms-CALP|KCHIP4
Cytomap

19p12

4p15.31-p15.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 430Kv channel-interacting protein 4Kv channel interacting protein 4a-type potassium channel modulatory protein 4calsenilin-like protein
Modification date2020031320200313
UniProtAcc.

Q6PIL6

Ensembl transtripts involved in fusion geneENST00000261560, ENST00000595401, 
ENST00000599548, 		ENST00000359001, 
ENST00000382149, ENST00000509207, 
ENST00000382148, ENST00000382150, 
ENST00000382152, ENST00000447367, 
Fusion gene scores* DoF score6 X 2 X 5=6018 X 13 X 9=2106
# samples 619
** MAII scorelog2(6/60*10)=0log2(19/2106*10)=-3.47043411269477
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF430 [Title/Abstract] AND KCNIP4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF430(21216990)-KCNIP4(20852290), # samples:2
Anticipated loss of major functional domain due to fusion event.ZNF430-KCNIP4 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ZNF430-KCNIP4 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ZNF430 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KCNIP4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-GV-A3JZ-01AZNF430chr19

21216990

-KCNIP4chr4

20852290

-
ChimerDB4BLCATCGA-GV-A3JZ-01AZNF430chr19

21216990

+KCNIP4chr4

20852290

-


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Fusion Gene ORF analysis for ZNF430-KCNIP4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000261560ENST00000359001ZNF430chr19

21216990

+KCNIP4chr4

20852290

-
5CDS-5UTRENST00000261560ENST00000382149ZNF430chr19

21216990

+KCNIP4chr4

20852290

-
5CDS-5UTRENST00000261560ENST00000509207ZNF430chr19

21216990

+KCNIP4chr4

20852290

-
5CDS-5UTRENST00000595401ENST00000359001ZNF430chr19

21216990

+KCNIP4chr4

20852290

-
5CDS-5UTRENST00000595401ENST00000382149ZNF430chr19

21216990

+KCNIP4chr4

20852290

-
5CDS-5UTRENST00000595401ENST00000509207ZNF430chr19

21216990

+KCNIP4chr4

20852290

-
5CDS-5UTRENST00000599548ENST00000359001ZNF430chr19

21216990

+KCNIP4chr4

20852290

-
5CDS-5UTRENST00000599548ENST00000382149ZNF430chr19

21216990

+KCNIP4chr4

20852290

-
5CDS-5UTRENST00000599548ENST00000509207ZNF430chr19

21216990

+KCNIP4chr4

20852290

-
Frame-shiftENST00000595401ENST00000382148ZNF430chr19

21216990

+KCNIP4chr4

20852290

-
Frame-shiftENST00000595401ENST00000382150ZNF430chr19

21216990

+KCNIP4chr4

20852290

-
Frame-shiftENST00000595401ENST00000382152ZNF430chr19

21216990

+KCNIP4chr4

20852290

-
Frame-shiftENST00000595401ENST00000447367ZNF430chr19

21216990

+KCNIP4chr4

20852290

-
In-frameENST00000261560ENST00000382148ZNF430chr19

21216990

+KCNIP4chr4

20852290

-
In-frameENST00000261560ENST00000382150ZNF430chr19

21216990

+KCNIP4chr4

20852290

-
In-frameENST00000261560ENST00000382152ZNF430chr19

21216990

+KCNIP4chr4

20852290

-
In-frameENST00000261560ENST00000447367ZNF430chr19

21216990

+KCNIP4chr4

20852290

-
In-frameENST00000599548ENST00000382148ZNF430chr19

21216990

+KCNIP4chr4

20852290

-
In-frameENST00000599548ENST00000382150ZNF430chr19

21216990

+KCNIP4chr4

20852290

-
In-frameENST00000599548ENST00000382152ZNF430chr19

21216990

+KCNIP4chr4

20852290

-
In-frameENST00000599548ENST00000447367ZNF430chr19

21216990

+KCNIP4chr4

20852290

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000261560ZNF430chr1921216990+ENST00000382148KCNIP4chr420852290-25595031811092303
ENST00000261560ZNF430chr1921216990+ENST00000447367KCNIP4chr420852290-19695031811092303
ENST00000261560ZNF430chr1921216990+ENST00000382150KCNIP4chr420852290-19655031811092303
ENST00000261560ZNF430chr1921216990+ENST00000382152KCNIP4chr420852290-19395031811092303
ENST00000599548ZNF430chr1921216990+ENST00000382148KCNIP4chr420852290-25454891671078303
ENST00000599548ZNF430chr1921216990+ENST00000447367KCNIP4chr420852290-19554891671078303
ENST00000599548ZNF430chr1921216990+ENST00000382150KCNIP4chr420852290-19514891671078303
ENST00000599548ZNF430chr1921216990+ENST00000382152KCNIP4chr420852290-19254891671078303

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261560ENST00000382148ZNF430chr1921216990+KCNIP4chr420852290-0.0005894420.9994105
ENST00000261560ENST00000447367ZNF430chr1921216990+KCNIP4chr420852290-0.0005417380.99945825
ENST00000261560ENST00000382150ZNF430chr1921216990+KCNIP4chr420852290-0.0005384440.9994616
ENST00000261560ENST00000382152ZNF430chr1921216990+KCNIP4chr420852290-0.000541140.99945885
ENST00000599548ENST00000382148ZNF430chr1921216990+KCNIP4chr420852290-0.0006284080.9993716
ENST00000599548ENST00000447367ZNF430chr1921216990+KCNIP4chr420852290-0.0005735230.9994265
ENST00000599548ENST00000382150ZNF430chr1921216990+KCNIP4chr420852290-0.0005643140.9994357
ENST00000599548ENST00000382152ZNF430chr1921216990+KCNIP4chr420852290-0.0005704460.9994295

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Fusion Genomic Features for ZNF430-KCNIP4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF430-KCNIP4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:21216990/chr4:20852290)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.KCNIP4

Q6PIL6

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner (PubMed:11847232, PubMed:18957440, PubMed:23576435). Modulates KCND3/Kv4.3 currents (PubMed:23576435). Isoform 4 does not increase KCND2 expression at the cell membrane (PubMed:18957440). Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane. {ECO:0000250|UniProtKB:Q6PHZ8, ECO:0000269|PubMed:11847232, ECO:0000269|PubMed:18957440, ECO:0000269|PubMed:23576435}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF430chr19:21216990chr4:20852290ENST00000261560+4535_107107571.0DomainKRAB
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000035900108133_1440189.0Calcium binding1
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000035900108169_1800189.0Calcium binding2
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000035900108217_2280189.0Calcium binding3
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000038214808133_14429226.0Calcium binding1
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000038214808169_18029226.0Calcium binding2
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000038214808217_22829226.0Calcium binding3
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000038215008133_14433230.0Calcium binding1
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000038215008169_18033230.0Calcium binding2
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000038215008217_22833230.0Calcium binding3
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000038215219133_14454251.0Calcium binding1
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000038215219169_18054251.0Calcium binding2
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000038215219217_22854251.0Calcium binding3
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000044736708133_14420217.0Calcium binding1
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000044736708169_18020217.0Calcium binding2
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000044736708217_22820217.0Calcium binding3
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000050920708133_1440189.0Calcium binding1
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000050920708169_1800189.0Calcium binding2
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000050920708217_2280189.0Calcium binding3
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000035900108120_1550189.0DomainEF-hand 2
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000035900108156_1910189.0DomainEF-hand 3
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000035900108204_2390189.0DomainEF-hand 4
TgeneKCNIP4chr19:21216990chr4:20852290ENST000003590010861_1170189.0DomainEF-hand 1%3B degenerate
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000038214808120_15529226.0DomainEF-hand 2
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000038214808156_19129226.0DomainEF-hand 3
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000038214808204_23929226.0DomainEF-hand 4
TgeneKCNIP4chr19:21216990chr4:20852290ENST000003821480861_11729226.0DomainEF-hand 1%3B degenerate
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000038215008120_15533230.0DomainEF-hand 2
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000038215008156_19133230.0DomainEF-hand 3
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000038215008204_23933230.0DomainEF-hand 4
TgeneKCNIP4chr19:21216990chr4:20852290ENST000003821500861_11733230.0DomainEF-hand 1%3B degenerate
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000038215219120_15554251.0DomainEF-hand 2
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000038215219156_19154251.0DomainEF-hand 3
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000038215219204_23954251.0DomainEF-hand 4
TgeneKCNIP4chr19:21216990chr4:20852290ENST000003821521961_11754251.0DomainEF-hand 1%3B degenerate
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000044736708120_15520217.0DomainEF-hand 2
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000044736708156_19120217.0DomainEF-hand 3
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000044736708204_23920217.0DomainEF-hand 4
TgeneKCNIP4chr19:21216990chr4:20852290ENST000004473670861_11720217.0DomainEF-hand 1%3B degenerate
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000050920708120_1550189.0DomainEF-hand 2
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000050920708156_1910189.0DomainEF-hand 3
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000050920708204_2390189.0DomainEF-hand 4
TgeneKCNIP4chr19:21216990chr4:20852290ENST000005092070861_1170189.0DomainEF-hand 1%3B degenerate
TgeneKCNIP4chr19:21216990chr4:20852290ENST00000359001082_440189.0RegionKIS
TgeneKCNIP4chr19:21216990chr4:20852290ENST00000509207082_440189.0RegionKIS

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF430chr19:21216990chr4:20852290ENST00000261560+45205_227107571.0Zinc fingerC2H2-type 1
HgeneZNF430chr19:21216990chr4:20852290ENST00000261560+45233_255107571.0Zinc fingerC2H2-type 2
HgeneZNF430chr19:21216990chr4:20852290ENST00000261560+45261_283107571.0Zinc fingerC2H2-type 3
HgeneZNF430chr19:21216990chr4:20852290ENST00000261560+45289_311107571.0Zinc fingerC2H2-type 4
HgeneZNF430chr19:21216990chr4:20852290ENST00000261560+45317_339107571.0Zinc fingerC2H2-type 5
HgeneZNF430chr19:21216990chr4:20852290ENST00000261560+45345_367107571.0Zinc fingerC2H2-type 6
HgeneZNF430chr19:21216990chr4:20852290ENST00000261560+45373_395107571.0Zinc fingerC2H2-type 7
HgeneZNF430chr19:21216990chr4:20852290ENST00000261560+45401_423107571.0Zinc fingerC2H2-type 8
HgeneZNF430chr19:21216990chr4:20852290ENST00000261560+45429_451107571.0Zinc fingerC2H2-type 9
HgeneZNF430chr19:21216990chr4:20852290ENST00000261560+45457_479107571.0Zinc fingerC2H2-type 10
HgeneZNF430chr19:21216990chr4:20852290ENST00000261560+45485_507107571.0Zinc fingerC2H2-type 11
HgeneZNF430chr19:21216990chr4:20852290ENST00000261560+45513_535107571.0Zinc fingerC2H2-type 12%3B degenerate
TgeneKCNIP4chr19:21216990chr4:20852290ENST00000382148082_4429226.0RegionKIS
TgeneKCNIP4chr19:21216990chr4:20852290ENST00000382150082_4433230.0RegionKIS
TgeneKCNIP4chr19:21216990chr4:20852290ENST00000382152192_4454251.0RegionKIS
TgeneKCNIP4chr19:21216990chr4:20852290ENST00000447367082_4420217.0RegionKIS


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Fusion Gene Sequence for ZNF430-KCNIP4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>102082_102082_1_ZNF430-KCNIP4_ZNF430_chr19_21216990_ENST00000261560_KCNIP4_chr4_20852290_ENST00000382148_length(transcript)=2559nt_BP=503nt
AGCGGACAGGGCGGCTTCCGGGTTTGGCGGGGCCTTTGTCCCTCGCTGTGGCCTGAGCTCCAGGTCTCGTCTTCAGCGCTCTGTGTCCTC
TGCTCCTAGAGGTCCAGGCTCTGTGGCCCTGTGACCCGCAGGTATTGGGAGATCTACAGCTAAGACGCCAGGAACCCCTGGAAGCCTAGA
AATGGAGAACCTGAAGTCTGGAGTGTATCCTCTCAAGGAAGCAAGTGGATGCCCTGGGGCTGACAGGAATCTTCTGGTGTACTCTTTTTA
TGAAAAGGGGCCATTGACATTTAGGGATGTGGCCATAGAATTTTCTCTGGAGGAGTGGCAATGCCTGGACACTGCTCAGCAGGATTTGTA
TAGAAAAGTGATGTTAGAGAACTACAGAAACCTGGTCTTCTTGGCAGGTATTGCTGTTTCTAAGCCAGACCTGATCACCTGTCTAGAGCA
AGGAAAAGAGCCCTGGAATATGAAGAGACATGCGATGGTAGATCAACCCCCAGACAGCGTGGAAGATGAACTGGAGATGGCCACCGTCAG
GCATCGGCCTGAAGCCCTTGAGCTTCTGGAAGCCCAGAGCAAATTTACCAAGAAAGAGCTTCAGATCCTTTACAGAGGATTTAAGAATGA
ATGCCCCAGTGGTGTTGTTAATGAAGAAACCTTCAAAGAGATTTACTCGCAGTTCTTTCCACAGGGAGACTCTACAACATATGCACATTT
TCTGTTCAATGCATTTGATACAGACCACAATGGAGCTGTGAGTTTCGAGGATTTCATCAAAGGTCTTTCCATTTTGCTCCGGGGGACAGT
ACAAGAAAAACTCAATTGGGCATTTAATCTGTATGACATAAATAAAGATGGCTACATCACTAAAGAGGAAATGCTTGATATAATGAAAGC
AATATACGATATGATGGGTAAATGTACATATCCTGTCCTCAAAGAAGATGCTCCCAGACAACACGTTGAAACATTTTTTCAGAAAATGGA
CAAAAATAAAGATGGGGTTGTTACCATAGATGAGTTCATTGAAAGCTGCCAAAAAGATGAAAACATAATGCGCTCCATGCAGCTCTTTGA
AAATGTGATTTAACTTGTCAAATAGATCCTGAATCCAACAGACAAATGTGAACTATTCTACCACCCTTAAAGTTGGAGCTACCACTTTTA
GCATAGATTGCTCAGCTTGACACTGAAGCATATTATGCAAACAAGCTTTGTTTTAATATAAAGCAATCCCCAAAAGATTTGAGCTTTCAG
TTATAAATTTGCATCCTTTTCATAATGCCACTGAGTTCAGGGGATGGTCTAACTCATTTCATACTCTGTGAATATTCAAAAGTAATAGAA
TCTGGCATATAGTTTTATTGGTTCCTTAGCCATGGGATTATTGAGGCTTTCACATATCAGTGATTTTAAAATATCAGTGTTTTTTGCTAC
TCATTTGTATGTATTCAGTCCTAGGATTTTGAATGGTTTTCTAATATAGTGACATCTGCATTTAATTTCCAGAAATTAAATTAATTTTCA
TGTTTGAATGCTGTAATTCCATTTAAATTCCATTTATATACTTTAAGGAAACAAGATTACAACAATTAAAAAAACACATAGTTCCAGTTT
CTATGGCCTTCCCACCTTCTGTTAGAAATTAGTTTTATCTGGCATTTTTAAACATTTAAAAATTATTAAACATTTAAAAATTAGTTTATT
ATCAGATATCAGCATATGCCTAATAAAACTTATTTTAATAAGCATTTAATTTTCCATAATATGTTACAGCCAAGGCCTATATAATAATTT
TGGATTTGTTCAATCTTTCTTACAGGCTGTTTTCTATTGTATCAATCATTAGTATCAATCATTAAGTGGAAGTTGAAGAAGGCATCAAAC
AAAACAAGGATGTTTACAGACATATGCAAAGGGTCAGGATATCTATCCTCCAGTATATAGTAATGCTTAATAACAAGTAATCCTAACAGC
ATTAAAGGCCAAATCTGTCCTCTTTCCCCTGACTTCCTTACAGCATGTTTATTTATATTACAAGCCATTCAGGGACAAAGAAAGAAACCT
TGACTACCCCACTGTCTACTAAGAACAAACAGCAAGCAAAATTAGCAAGCAAAATTCACTTTGAAAGCACCAGTGGTTCCATTACATTGA
CAACTACTACCAAGATTTAGTAGAAAATAAGTGCTCAACAACTAATCCAGATTACAGTATGATTTAGCTCATCATAATTCAGATTATTTT
TAATCATCTTAGCCAAAACTGTAAAGTTGCCACATTACTAAAGCCACACACATCGTCCCTGTTTTGTAGAAATATCACAAAGACCAAGAG
GCTACAGAAGGAGGAAATTTGCAACTGTCTTTGCAACAATAAATCAGGTATCTATTCTGGTGTAGAGATAGGATGTTGAAAGCTGCCCTG
CTATCACCAGTGTAGAAATTAAGAGTAGTACAATACATGTACACTGAAATTTGCCATCACGTGTTTGTGTAAACTCAATGTGCACATTTT

>102082_102082_1_ZNF430-KCNIP4_ZNF430_chr19_21216990_ENST00000261560_KCNIP4_chr4_20852290_ENST00000382148_length(amino acids)=303AA_BP=107
MENLKSGVYPLKEASGCPGADRNLLVYSFYEKGPLTFRDVAIEFSLEEWQCLDTAQQDLYRKVMLENYRNLVFLAGIAVSKPDLITCLEQ
GKEPWNMKRHAMVDQPPDSVEDELEMATVRHRPEALELLEAQSKFTKKELQILYRGFKNECPSGVVNEETFKEIYSQFFPQGDSTTYAHF
LFNAFDTDHNGAVSFEDFIKGLSILLRGTVQEKLNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKCTYPVLKEDAPRQHVETFFQKMD

--------------------------------------------------------------
>102082_102082_2_ZNF430-KCNIP4_ZNF430_chr19_21216990_ENST00000261560_KCNIP4_chr4_20852290_ENST00000382150_length(transcript)=1965nt_BP=503nt
AGCGGACAGGGCGGCTTCCGGGTTTGGCGGGGCCTTTGTCCCTCGCTGTGGCCTGAGCTCCAGGTCTCGTCTTCAGCGCTCTGTGTCCTC
TGCTCCTAGAGGTCCAGGCTCTGTGGCCCTGTGACCCGCAGGTATTGGGAGATCTACAGCTAAGACGCCAGGAACCCCTGGAAGCCTAGA
AATGGAGAACCTGAAGTCTGGAGTGTATCCTCTCAAGGAAGCAAGTGGATGCCCTGGGGCTGACAGGAATCTTCTGGTGTACTCTTTTTA
TGAAAAGGGGCCATTGACATTTAGGGATGTGGCCATAGAATTTTCTCTGGAGGAGTGGCAATGCCTGGACACTGCTCAGCAGGATTTGTA
TAGAAAAGTGATGTTAGAGAACTACAGAAACCTGGTCTTCTTGGCAGGTATTGCTGTTTCTAAGCCAGACCTGATCACCTGTCTAGAGCA
AGGAAAAGAGCCCTGGAATATGAAGAGACATGCGATGGTAGATCAACCCCCAGACAGCGTGGAAGATGAACTGGAGATGGCCACCGTCAG
GCATCGGCCTGAAGCCCTTGAGCTTCTGGAAGCCCAGAGCAAATTTACCAAGAAAGAGCTTCAGATCCTTTACAGAGGATTTAAGAATGA
ATGCCCCAGTGGTGTTGTTAATGAAGAAACCTTCAAAGAGATTTACTCGCAGTTCTTTCCACAGGGAGACTCTACAACATATGCACATTT
TCTGTTCAATGCATTTGATACAGACCACAATGGAGCTGTGAGTTTCGAGGATTTCATCAAAGGTCTTTCCATTTTGCTCCGGGGGACAGT
ACAAGAAAAACTCAATTGGGCATTTAATCTGTATGACATAAATAAAGATGGCTACATCACTAAAGAGGAAATGCTTGATATAATGAAAGC
AATATACGATATGATGGGTAAATGTACATATCCTGTCCTCAAAGAAGATGCTCCCAGACAACACGTTGAAACATTTTTTCAGAAAATGGA
CAAAAATAAAGATGGGGTTGTTACCATAGATGAGTTCATTGAAAGCTGCCAAAAAGATGAAAACATAATGCGCTCCATGCAGCTCTTTGA
AAATGTGATTTAACTTGTCAAATAGATCCTGAATCCAACAGACAAATGTGAACTATTCTACCACCCTTAAAGTTGGAGCTACCACTTTTA
GCATAGATTGCTCAGCTTGACACTGAAGCATATTATGCAAACAAGCTTTGTTTTAATATAAAGCAATCCCCAAAAGATTTGAGCTTTCAG
TTATAAATTTGCATCCTTTTCATAATGCCACTGAGTTCAGGGGATGGTCTAACTCATTTCATACTCTGTGAATATTCAAAAGTAATAGAA
TCTGGCATATAGTTTTATTGGTTCCTTAGCCATGGGATTATTGAGGCTTTCACATATCAGTGATTTTAAAATATCAGTGTTTTTTGCTAC
TCATTTGTATGTATTCAGTCCTAGGATTTTGAATGGTTTTCTAATATAGTGACATCTGCATTTAATTTCCAGAAATTAAATTAATTTTCA
TGTTTGAATGCTGTAATTCCATTTAAATTCCATTTATATACTTTAAGGAAACAAGATTACAACAATTAAAAAAACACATAGTTCCAGTTT
CTATGGCCTTCCCACCTTCTGTTAGAAATTAGTTTTATCTGGCATTTTTAAACATTTAAAAATTATTAAACATTTAAAAATTAGTTTATT
ATCAGATATCAGCATATGCCTAATAAAACTTATTTTAATAAGCATTTAATTTTCCATAATATGTTACAGCCAAGGCCTATATAATAATTT
TGGATTTGTTCAATCTTTCTTACAGGCTGTTTTCTATTGTATCAATCATTAGTATCAATCATTAAGTGGAAGTTGAAGAAGGCATCAAAC

>102082_102082_2_ZNF430-KCNIP4_ZNF430_chr19_21216990_ENST00000261560_KCNIP4_chr4_20852290_ENST00000382150_length(amino acids)=303AA_BP=107
MENLKSGVYPLKEASGCPGADRNLLVYSFYEKGPLTFRDVAIEFSLEEWQCLDTAQQDLYRKVMLENYRNLVFLAGIAVSKPDLITCLEQ
GKEPWNMKRHAMVDQPPDSVEDELEMATVRHRPEALELLEAQSKFTKKELQILYRGFKNECPSGVVNEETFKEIYSQFFPQGDSTTYAHF
LFNAFDTDHNGAVSFEDFIKGLSILLRGTVQEKLNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKCTYPVLKEDAPRQHVETFFQKMD

--------------------------------------------------------------
>102082_102082_3_ZNF430-KCNIP4_ZNF430_chr19_21216990_ENST00000261560_KCNIP4_chr4_20852290_ENST00000382152_length(transcript)=1939nt_BP=503nt
AGCGGACAGGGCGGCTTCCGGGTTTGGCGGGGCCTTTGTCCCTCGCTGTGGCCTGAGCTCCAGGTCTCGTCTTCAGCGCTCTGTGTCCTC
TGCTCCTAGAGGTCCAGGCTCTGTGGCCCTGTGACCCGCAGGTATTGGGAGATCTACAGCTAAGACGCCAGGAACCCCTGGAAGCCTAGA
AATGGAGAACCTGAAGTCTGGAGTGTATCCTCTCAAGGAAGCAAGTGGATGCCCTGGGGCTGACAGGAATCTTCTGGTGTACTCTTTTTA
TGAAAAGGGGCCATTGACATTTAGGGATGTGGCCATAGAATTTTCTCTGGAGGAGTGGCAATGCCTGGACACTGCTCAGCAGGATTTGTA
TAGAAAAGTGATGTTAGAGAACTACAGAAACCTGGTCTTCTTGGCAGGTATTGCTGTTTCTAAGCCAGACCTGATCACCTGTCTAGAGCA
AGGAAAAGAGCCCTGGAATATGAAGAGACATGCGATGGTAGATCAACCCCCAGACAGCGTGGAAGATGAACTGGAGATGGCCACCGTCAG
GCATCGGCCTGAAGCCCTTGAGCTTCTGGAAGCCCAGAGCAAATTTACCAAGAAAGAGCTTCAGATCCTTTACAGAGGATTTAAGAATGA
ATGCCCCAGTGGTGTTGTTAATGAAGAAACCTTCAAAGAGATTTACTCGCAGTTCTTTCCACAGGGAGACTCTACAACATATGCACATTT
TCTGTTCAATGCATTTGATACAGACCACAATGGAGCTGTGAGTTTCGAGGATTTCATCAAAGGTCTTTCCATTTTGCTCCGGGGGACAGT
ACAAGAAAAACTCAATTGGGCATTTAATCTGTATGACATAAATAAAGATGGCTACATCACTAAAGAGGAAATGCTTGATATAATGAAAGC
AATATACGATATGATGGGTAAATGTACATATCCTGTCCTCAAAGAAGATGCTCCCAGACAACACGTTGAAACATTTTTTCAGAAAATGGA
CAAAAATAAAGATGGGGTTGTTACCATAGATGAGTTCATTGAAAGCTGCCAAAAAGATGAAAACATAATGCGCTCCATGCAGCTCTTTGA
AAATGTGATTTAACTTGTCAAATAGATCCTGAATCCAACAGACAAATGTGAACTATTCTACCACCCTTAAAGTTGGAGCTACCACTTTTA
GCATAGATTGCTCAGCTTGACACTGAAGCATATTATGCAAACAAGCTTTGTTTTAATATAAAGCAATCCCCAAAAGATTTGAGCTTTCAG
TTATAAATTTGCATCCTTTTCATAATGCCACTGAGTTCAGGGGATGGTCTAACTCATTTCATACTCTGTGAATATTCAAAAGTAATAGAA
TCTGGCATATAGTTTTATTGGTTCCTTAGCCATGGGATTATTGAGGCTTTCACATATCAGTGATTTTAAAATATCAGTGTTTTTTGCTAC
TCATTTGTATGTATTCAGTCCTAGGATTTTGAATGGTTTTCTAATATAGTGACATCTGCATTTAATTTCCAGAAATTAAATTAATTTTCA
TGTTTGAATGCTGTAATTCCATTTAAATTCCATTTATATACTTTAAGGAAACAAGATTACAACAATTAAAAAAACACATAGTTCCAGTTT
CTATGGCCTTCCCACCTTCTGTTAGAAATTAGTTTTATCTGGCATTTTTAAACATTTAAAAATTATTAAACATTTAAAAATTAGTTTATT
ATCAGATATCAGCATATGCCTAATAAAACTTATTTTAATAAGCATTTAATTTTCCATAATATGTTACAGCCAAGGCCTATATAATAATTT
TGGATTTGTTCAATCTTTCTTACAGGCTGTTTTCTATTGTATCAATCATTAGTATCAATCATTAAGTGGAAGTTGAAGAAGGCATCAAAC

>102082_102082_3_ZNF430-KCNIP4_ZNF430_chr19_21216990_ENST00000261560_KCNIP4_chr4_20852290_ENST00000382152_length(amino acids)=303AA_BP=107
MENLKSGVYPLKEASGCPGADRNLLVYSFYEKGPLTFRDVAIEFSLEEWQCLDTAQQDLYRKVMLENYRNLVFLAGIAVSKPDLITCLEQ
GKEPWNMKRHAMVDQPPDSVEDELEMATVRHRPEALELLEAQSKFTKKELQILYRGFKNECPSGVVNEETFKEIYSQFFPQGDSTTYAHF
LFNAFDTDHNGAVSFEDFIKGLSILLRGTVQEKLNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKCTYPVLKEDAPRQHVETFFQKMD

--------------------------------------------------------------
>102082_102082_4_ZNF430-KCNIP4_ZNF430_chr19_21216990_ENST00000261560_KCNIP4_chr4_20852290_ENST00000447367_length(transcript)=1969nt_BP=503nt
AGCGGACAGGGCGGCTTCCGGGTTTGGCGGGGCCTTTGTCCCTCGCTGTGGCCTGAGCTCCAGGTCTCGTCTTCAGCGCTCTGTGTCCTC
TGCTCCTAGAGGTCCAGGCTCTGTGGCCCTGTGACCCGCAGGTATTGGGAGATCTACAGCTAAGACGCCAGGAACCCCTGGAAGCCTAGA
AATGGAGAACCTGAAGTCTGGAGTGTATCCTCTCAAGGAAGCAAGTGGATGCCCTGGGGCTGACAGGAATCTTCTGGTGTACTCTTTTTA
TGAAAAGGGGCCATTGACATTTAGGGATGTGGCCATAGAATTTTCTCTGGAGGAGTGGCAATGCCTGGACACTGCTCAGCAGGATTTGTA
TAGAAAAGTGATGTTAGAGAACTACAGAAACCTGGTCTTCTTGGCAGGTATTGCTGTTTCTAAGCCAGACCTGATCACCTGTCTAGAGCA
AGGAAAAGAGCCCTGGAATATGAAGAGACATGCGATGGTAGATCAACCCCCAGACAGCGTGGAAGATGAACTGGAGATGGCCACCGTCAG
GCATCGGCCTGAAGCCCTTGAGCTTCTGGAAGCCCAGAGCAAATTTACCAAGAAAGAGCTTCAGATCCTTTACAGAGGATTTAAGAATGA
ATGCCCCAGTGGTGTTGTTAATGAAGAAACCTTCAAAGAGATTTACTCGCAGTTCTTTCCACAGGGAGACTCTACAACATATGCACATTT
TCTGTTCAATGCATTTGATACAGACCACAATGGAGCTGTGAGTTTCGAGGATTTCATCAAAGGTCTTTCCATTTTGCTCCGGGGGACAGT
ACAAGAAAAACTCAATTGGGCATTTAATCTGTATGACATAAATAAAGATGGCTACATCACTAAAGAGGAAATGCTTGATATAATGAAAGC
AATATACGATATGATGGGTAAATGTACATATCCTGTCCTCAAAGAAGATGCTCCCAGACAACACGTTGAAACATTTTTTCAGAAAATGGA
CAAAAATAAAGATGGGGTTGTTACCATAGATGAGTTCATTGAAAGCTGCCAAAAAGATGAAAACATAATGCGCTCCATGCAGCTCTTTGA
AAATGTGATTTAACTTGTCAAATAGATCCTGAATCCAACAGACAAATGTGAACTATTCTACCACCCTTAAAGTTGGAGCTACCACTTTTA
GCATAGATTGCTCAGCTTGACACTGAAGCATATTATGCAAACAAGCTTTGTTTTAATATAAAGCAATCCCCAAAAGATTTGAGCTTTCAG
TTATAAATTTGCATCCTTTTCATAATGCCACTGAGTTCAGGGGATGGTCTAACTCATTTCATACTCTGTGAATATTCAAAAGTAATAGAA
TCTGGCATATAGTTTTATTGGTTCCTTAGCCATGGGATTATTGAGGCTTTCACATATCAGTGATTTTAAAATATCAGTGTTTTTTGCTAC
TCATTTGTATGTATTCAGTCCTAGGATTTTGAATGGTTTTCTAATATAGTGACATCTGCATTTAATTTCCAGAAATTAAATTAATTTTCA
TGTTTGAATGCTGTAATTCCATTTAAATTCCATTTATATACTTTAAGGAAACAAGATTACAACAATTAAAAAAACACATAGTTCCAGTTT
CTATGGCCTTCCCACCTTCTGTTAGAAATTAGTTTTATCTGGCATTTTTAAACATTTAAAAATTATTAAACATTTAAAAATTAGTTTATT
ATCAGATATCAGCATATGCCTAATAAAACTTATTTTAATAAGCATTTAATTTTCCATAATATGTTACAGCCAAGGCCTATATAATAATTT
TGGATTTGTTCAATCTTTCTTACAGGCTGTTTTCTATTGTATCAATCATTAGTATCAATCATTAAGTGGAAGTTGAAGAAGGCATCAAAC

>102082_102082_4_ZNF430-KCNIP4_ZNF430_chr19_21216990_ENST00000261560_KCNIP4_chr4_20852290_ENST00000447367_length(amino acids)=303AA_BP=107
MENLKSGVYPLKEASGCPGADRNLLVYSFYEKGPLTFRDVAIEFSLEEWQCLDTAQQDLYRKVMLENYRNLVFLAGIAVSKPDLITCLEQ
GKEPWNMKRHAMVDQPPDSVEDELEMATVRHRPEALELLEAQSKFTKKELQILYRGFKNECPSGVVNEETFKEIYSQFFPQGDSTTYAHF
LFNAFDTDHNGAVSFEDFIKGLSILLRGTVQEKLNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKCTYPVLKEDAPRQHVETFFQKMD

--------------------------------------------------------------
>102082_102082_5_ZNF430-KCNIP4_ZNF430_chr19_21216990_ENST00000599548_KCNIP4_chr4_20852290_ENST00000382148_length(transcript)=2545nt_BP=489nt
CTTCCGGGTTTGGCGGGGCCTTTGTCCCTCGCTGTGGCCTGAGCTCCAGGTCTCGTCTTCAGCGCTCTGTGTCCTCTGCTCCTAGAGGTC
CAGGCTCTGTGGCCCTGTGACCCGCAGGTATTGGGAGATCTACAGCTAAGACGCCAGGAACCCCTGGAAGCCTAGAAATGGAGAACCTGA
AGTCTGGAGTGTATCCTCTCAAGGAAGCAAGTGGATGCCCTGGGGCTGACAGGAATCTTCTGGTGTACTCTTTTTATGAAAAGGGGCCAT
TGACATTTAGGGATGTGGCCATAGAATTTTCTCTGGAGGAGTGGCAATGCCTGGACACTGCTCAGCAGGATTTGTATAGAAAAGTGATGT
TAGAGAACTACAGAAACCTGGTCTTCTTGGCAGGTATTGCTGTTTCTAAGCCAGACCTGATCACCTGTCTAGAGCAAGGAAAAGAGCCCT
GGAATATGAAGAGACATGCGATGGTAGATCAACCCCCAGACAGCGTGGAAGATGAACTGGAGATGGCCACCGTCAGGCATCGGCCTGAAG
CCCTTGAGCTTCTGGAAGCCCAGAGCAAATTTACCAAGAAAGAGCTTCAGATCCTTTACAGAGGATTTAAGAATGAATGCCCCAGTGGTG
TTGTTAATGAAGAAACCTTCAAAGAGATTTACTCGCAGTTCTTTCCACAGGGAGACTCTACAACATATGCACATTTTCTGTTCAATGCAT
TTGATACAGACCACAATGGAGCTGTGAGTTTCGAGGATTTCATCAAAGGTCTTTCCATTTTGCTCCGGGGGACAGTACAAGAAAAACTCA
ATTGGGCATTTAATCTGTATGACATAAATAAAGATGGCTACATCACTAAAGAGGAAATGCTTGATATAATGAAAGCAATATACGATATGA
TGGGTAAATGTACATATCCTGTCCTCAAAGAAGATGCTCCCAGACAACACGTTGAAACATTTTTTCAGAAAATGGACAAAAATAAAGATG
GGGTTGTTACCATAGATGAGTTCATTGAAAGCTGCCAAAAAGATGAAAACATAATGCGCTCCATGCAGCTCTTTGAAAATGTGATTTAAC
TTGTCAAATAGATCCTGAATCCAACAGACAAATGTGAACTATTCTACCACCCTTAAAGTTGGAGCTACCACTTTTAGCATAGATTGCTCA
GCTTGACACTGAAGCATATTATGCAAACAAGCTTTGTTTTAATATAAAGCAATCCCCAAAAGATTTGAGCTTTCAGTTATAAATTTGCAT
CCTTTTCATAATGCCACTGAGTTCAGGGGATGGTCTAACTCATTTCATACTCTGTGAATATTCAAAAGTAATAGAATCTGGCATATAGTT
TTATTGGTTCCTTAGCCATGGGATTATTGAGGCTTTCACATATCAGTGATTTTAAAATATCAGTGTTTTTTGCTACTCATTTGTATGTAT
TCAGTCCTAGGATTTTGAATGGTTTTCTAATATAGTGACATCTGCATTTAATTTCCAGAAATTAAATTAATTTTCATGTTTGAATGCTGT
AATTCCATTTAAATTCCATTTATATACTTTAAGGAAACAAGATTACAACAATTAAAAAAACACATAGTTCCAGTTTCTATGGCCTTCCCA
CCTTCTGTTAGAAATTAGTTTTATCTGGCATTTTTAAACATTTAAAAATTATTAAACATTTAAAAATTAGTTTATTATCAGATATCAGCA
TATGCCTAATAAAACTTATTTTAATAAGCATTTAATTTTCCATAATATGTTACAGCCAAGGCCTATATAATAATTTTGGATTTGTTCAAT
CTTTCTTACAGGCTGTTTTCTATTGTATCAATCATTAGTATCAATCATTAAGTGGAAGTTGAAGAAGGCATCAAACAAAACAAGGATGTT
TACAGACATATGCAAAGGGTCAGGATATCTATCCTCCAGTATATAGTAATGCTTAATAACAAGTAATCCTAACAGCATTAAAGGCCAAAT
CTGTCCTCTTTCCCCTGACTTCCTTACAGCATGTTTATTTATATTACAAGCCATTCAGGGACAAAGAAAGAAACCTTGACTACCCCACTG
TCTACTAAGAACAAACAGCAAGCAAAATTAGCAAGCAAAATTCACTTTGAAAGCACCAGTGGTTCCATTACATTGACAACTACTACCAAG
ATTTAGTAGAAAATAAGTGCTCAACAACTAATCCAGATTACAGTATGATTTAGCTCATCATAATTCAGATTATTTTTAATCATCTTAGCC
AAAACTGTAAAGTTGCCACATTACTAAAGCCACACACATCGTCCCTGTTTTGTAGAAATATCACAAAGACCAAGAGGCTACAGAAGGAGG
AAATTTGCAACTGTCTTTGCAACAATAAATCAGGTATCTATTCTGGTGTAGAGATAGGATGTTGAAAGCTGCCCTGCTATCACCAGTGTA
GAAATTAAGAGTAGTACAATACATGTACACTGAAATTTGCCATCACGTGTTTGTGTAAACTCAATGTGCACATTTTGTATTTCAAAAAGA

>102082_102082_5_ZNF430-KCNIP4_ZNF430_chr19_21216990_ENST00000599548_KCNIP4_chr4_20852290_ENST00000382148_length(amino acids)=303AA_BP=107
MENLKSGVYPLKEASGCPGADRNLLVYSFYEKGPLTFRDVAIEFSLEEWQCLDTAQQDLYRKVMLENYRNLVFLAGIAVSKPDLITCLEQ
GKEPWNMKRHAMVDQPPDSVEDELEMATVRHRPEALELLEAQSKFTKKELQILYRGFKNECPSGVVNEETFKEIYSQFFPQGDSTTYAHF
LFNAFDTDHNGAVSFEDFIKGLSILLRGTVQEKLNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKCTYPVLKEDAPRQHVETFFQKMD

--------------------------------------------------------------
>102082_102082_6_ZNF430-KCNIP4_ZNF430_chr19_21216990_ENST00000599548_KCNIP4_chr4_20852290_ENST00000382150_length(transcript)=1951nt_BP=489nt
CTTCCGGGTTTGGCGGGGCCTTTGTCCCTCGCTGTGGCCTGAGCTCCAGGTCTCGTCTTCAGCGCTCTGTGTCCTCTGCTCCTAGAGGTC
CAGGCTCTGTGGCCCTGTGACCCGCAGGTATTGGGAGATCTACAGCTAAGACGCCAGGAACCCCTGGAAGCCTAGAAATGGAGAACCTGA
AGTCTGGAGTGTATCCTCTCAAGGAAGCAAGTGGATGCCCTGGGGCTGACAGGAATCTTCTGGTGTACTCTTTTTATGAAAAGGGGCCAT
TGACATTTAGGGATGTGGCCATAGAATTTTCTCTGGAGGAGTGGCAATGCCTGGACACTGCTCAGCAGGATTTGTATAGAAAAGTGATGT
TAGAGAACTACAGAAACCTGGTCTTCTTGGCAGGTATTGCTGTTTCTAAGCCAGACCTGATCACCTGTCTAGAGCAAGGAAAAGAGCCCT
GGAATATGAAGAGACATGCGATGGTAGATCAACCCCCAGACAGCGTGGAAGATGAACTGGAGATGGCCACCGTCAGGCATCGGCCTGAAG
CCCTTGAGCTTCTGGAAGCCCAGAGCAAATTTACCAAGAAAGAGCTTCAGATCCTTTACAGAGGATTTAAGAATGAATGCCCCAGTGGTG
TTGTTAATGAAGAAACCTTCAAAGAGATTTACTCGCAGTTCTTTCCACAGGGAGACTCTACAACATATGCACATTTTCTGTTCAATGCAT
TTGATACAGACCACAATGGAGCTGTGAGTTTCGAGGATTTCATCAAAGGTCTTTCCATTTTGCTCCGGGGGACAGTACAAGAAAAACTCA
ATTGGGCATTTAATCTGTATGACATAAATAAAGATGGCTACATCACTAAAGAGGAAATGCTTGATATAATGAAAGCAATATACGATATGA
TGGGTAAATGTACATATCCTGTCCTCAAAGAAGATGCTCCCAGACAACACGTTGAAACATTTTTTCAGAAAATGGACAAAAATAAAGATG
GGGTTGTTACCATAGATGAGTTCATTGAAAGCTGCCAAAAAGATGAAAACATAATGCGCTCCATGCAGCTCTTTGAAAATGTGATTTAAC
TTGTCAAATAGATCCTGAATCCAACAGACAAATGTGAACTATTCTACCACCCTTAAAGTTGGAGCTACCACTTTTAGCATAGATTGCTCA
GCTTGACACTGAAGCATATTATGCAAACAAGCTTTGTTTTAATATAAAGCAATCCCCAAAAGATTTGAGCTTTCAGTTATAAATTTGCAT
CCTTTTCATAATGCCACTGAGTTCAGGGGATGGTCTAACTCATTTCATACTCTGTGAATATTCAAAAGTAATAGAATCTGGCATATAGTT
TTATTGGTTCCTTAGCCATGGGATTATTGAGGCTTTCACATATCAGTGATTTTAAAATATCAGTGTTTTTTGCTACTCATTTGTATGTAT
TCAGTCCTAGGATTTTGAATGGTTTTCTAATATAGTGACATCTGCATTTAATTTCCAGAAATTAAATTAATTTTCATGTTTGAATGCTGT
AATTCCATTTAAATTCCATTTATATACTTTAAGGAAACAAGATTACAACAATTAAAAAAACACATAGTTCCAGTTTCTATGGCCTTCCCA
CCTTCTGTTAGAAATTAGTTTTATCTGGCATTTTTAAACATTTAAAAATTATTAAACATTTAAAAATTAGTTTATTATCAGATATCAGCA
TATGCCTAATAAAACTTATTTTAATAAGCATTTAATTTTCCATAATATGTTACAGCCAAGGCCTATATAATAATTTTGGATTTGTTCAAT
CTTTCTTACAGGCTGTTTTCTATTGTATCAATCATTAGTATCAATCATTAAGTGGAAGTTGAAGAAGGCATCAAACAAAACAAGGATGTT

>102082_102082_6_ZNF430-KCNIP4_ZNF430_chr19_21216990_ENST00000599548_KCNIP4_chr4_20852290_ENST00000382150_length(amino acids)=303AA_BP=107
MENLKSGVYPLKEASGCPGADRNLLVYSFYEKGPLTFRDVAIEFSLEEWQCLDTAQQDLYRKVMLENYRNLVFLAGIAVSKPDLITCLEQ
GKEPWNMKRHAMVDQPPDSVEDELEMATVRHRPEALELLEAQSKFTKKELQILYRGFKNECPSGVVNEETFKEIYSQFFPQGDSTTYAHF
LFNAFDTDHNGAVSFEDFIKGLSILLRGTVQEKLNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKCTYPVLKEDAPRQHVETFFQKMD

--------------------------------------------------------------
>102082_102082_7_ZNF430-KCNIP4_ZNF430_chr19_21216990_ENST00000599548_KCNIP4_chr4_20852290_ENST00000382152_length(transcript)=1925nt_BP=489nt
CTTCCGGGTTTGGCGGGGCCTTTGTCCCTCGCTGTGGCCTGAGCTCCAGGTCTCGTCTTCAGCGCTCTGTGTCCTCTGCTCCTAGAGGTC
CAGGCTCTGTGGCCCTGTGACCCGCAGGTATTGGGAGATCTACAGCTAAGACGCCAGGAACCCCTGGAAGCCTAGAAATGGAGAACCTGA
AGTCTGGAGTGTATCCTCTCAAGGAAGCAAGTGGATGCCCTGGGGCTGACAGGAATCTTCTGGTGTACTCTTTTTATGAAAAGGGGCCAT
TGACATTTAGGGATGTGGCCATAGAATTTTCTCTGGAGGAGTGGCAATGCCTGGACACTGCTCAGCAGGATTTGTATAGAAAAGTGATGT
TAGAGAACTACAGAAACCTGGTCTTCTTGGCAGGTATTGCTGTTTCTAAGCCAGACCTGATCACCTGTCTAGAGCAAGGAAAAGAGCCCT
GGAATATGAAGAGACATGCGATGGTAGATCAACCCCCAGACAGCGTGGAAGATGAACTGGAGATGGCCACCGTCAGGCATCGGCCTGAAG
CCCTTGAGCTTCTGGAAGCCCAGAGCAAATTTACCAAGAAAGAGCTTCAGATCCTTTACAGAGGATTTAAGAATGAATGCCCCAGTGGTG
TTGTTAATGAAGAAACCTTCAAAGAGATTTACTCGCAGTTCTTTCCACAGGGAGACTCTACAACATATGCACATTTTCTGTTCAATGCAT
TTGATACAGACCACAATGGAGCTGTGAGTTTCGAGGATTTCATCAAAGGTCTTTCCATTTTGCTCCGGGGGACAGTACAAGAAAAACTCA
ATTGGGCATTTAATCTGTATGACATAAATAAAGATGGCTACATCACTAAAGAGGAAATGCTTGATATAATGAAAGCAATATACGATATGA
TGGGTAAATGTACATATCCTGTCCTCAAAGAAGATGCTCCCAGACAACACGTTGAAACATTTTTTCAGAAAATGGACAAAAATAAAGATG
GGGTTGTTACCATAGATGAGTTCATTGAAAGCTGCCAAAAAGATGAAAACATAATGCGCTCCATGCAGCTCTTTGAAAATGTGATTTAAC
TTGTCAAATAGATCCTGAATCCAACAGACAAATGTGAACTATTCTACCACCCTTAAAGTTGGAGCTACCACTTTTAGCATAGATTGCTCA
GCTTGACACTGAAGCATATTATGCAAACAAGCTTTGTTTTAATATAAAGCAATCCCCAAAAGATTTGAGCTTTCAGTTATAAATTTGCAT
CCTTTTCATAATGCCACTGAGTTCAGGGGATGGTCTAACTCATTTCATACTCTGTGAATATTCAAAAGTAATAGAATCTGGCATATAGTT
TTATTGGTTCCTTAGCCATGGGATTATTGAGGCTTTCACATATCAGTGATTTTAAAATATCAGTGTTTTTTGCTACTCATTTGTATGTAT
TCAGTCCTAGGATTTTGAATGGTTTTCTAATATAGTGACATCTGCATTTAATTTCCAGAAATTAAATTAATTTTCATGTTTGAATGCTGT
AATTCCATTTAAATTCCATTTATATACTTTAAGGAAACAAGATTACAACAATTAAAAAAACACATAGTTCCAGTTTCTATGGCCTTCCCA
CCTTCTGTTAGAAATTAGTTTTATCTGGCATTTTTAAACATTTAAAAATTATTAAACATTTAAAAATTAGTTTATTATCAGATATCAGCA
TATGCCTAATAAAACTTATTTTAATAAGCATTTAATTTTCCATAATATGTTACAGCCAAGGCCTATATAATAATTTTGGATTTGTTCAAT
CTTTCTTACAGGCTGTTTTCTATTGTATCAATCATTAGTATCAATCATTAAGTGGAAGTTGAAGAAGGCATCAAACAAAACAAGGATGTT

>102082_102082_7_ZNF430-KCNIP4_ZNF430_chr19_21216990_ENST00000599548_KCNIP4_chr4_20852290_ENST00000382152_length(amino acids)=303AA_BP=107
MENLKSGVYPLKEASGCPGADRNLLVYSFYEKGPLTFRDVAIEFSLEEWQCLDTAQQDLYRKVMLENYRNLVFLAGIAVSKPDLITCLEQ
GKEPWNMKRHAMVDQPPDSVEDELEMATVRHRPEALELLEAQSKFTKKELQILYRGFKNECPSGVVNEETFKEIYSQFFPQGDSTTYAHF
LFNAFDTDHNGAVSFEDFIKGLSILLRGTVQEKLNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKCTYPVLKEDAPRQHVETFFQKMD

--------------------------------------------------------------
>102082_102082_8_ZNF430-KCNIP4_ZNF430_chr19_21216990_ENST00000599548_KCNIP4_chr4_20852290_ENST00000447367_length(transcript)=1955nt_BP=489nt
CTTCCGGGTTTGGCGGGGCCTTTGTCCCTCGCTGTGGCCTGAGCTCCAGGTCTCGTCTTCAGCGCTCTGTGTCCTCTGCTCCTAGAGGTC
CAGGCTCTGTGGCCCTGTGACCCGCAGGTATTGGGAGATCTACAGCTAAGACGCCAGGAACCCCTGGAAGCCTAGAAATGGAGAACCTGA
AGTCTGGAGTGTATCCTCTCAAGGAAGCAAGTGGATGCCCTGGGGCTGACAGGAATCTTCTGGTGTACTCTTTTTATGAAAAGGGGCCAT
TGACATTTAGGGATGTGGCCATAGAATTTTCTCTGGAGGAGTGGCAATGCCTGGACACTGCTCAGCAGGATTTGTATAGAAAAGTGATGT
TAGAGAACTACAGAAACCTGGTCTTCTTGGCAGGTATTGCTGTTTCTAAGCCAGACCTGATCACCTGTCTAGAGCAAGGAAAAGAGCCCT
GGAATATGAAGAGACATGCGATGGTAGATCAACCCCCAGACAGCGTGGAAGATGAACTGGAGATGGCCACCGTCAGGCATCGGCCTGAAG
CCCTTGAGCTTCTGGAAGCCCAGAGCAAATTTACCAAGAAAGAGCTTCAGATCCTTTACAGAGGATTTAAGAATGAATGCCCCAGTGGTG
TTGTTAATGAAGAAACCTTCAAAGAGATTTACTCGCAGTTCTTTCCACAGGGAGACTCTACAACATATGCACATTTTCTGTTCAATGCAT
TTGATACAGACCACAATGGAGCTGTGAGTTTCGAGGATTTCATCAAAGGTCTTTCCATTTTGCTCCGGGGGACAGTACAAGAAAAACTCA
ATTGGGCATTTAATCTGTATGACATAAATAAAGATGGCTACATCACTAAAGAGGAAATGCTTGATATAATGAAAGCAATATACGATATGA
TGGGTAAATGTACATATCCTGTCCTCAAAGAAGATGCTCCCAGACAACACGTTGAAACATTTTTTCAGAAAATGGACAAAAATAAAGATG
GGGTTGTTACCATAGATGAGTTCATTGAAAGCTGCCAAAAAGATGAAAACATAATGCGCTCCATGCAGCTCTTTGAAAATGTGATTTAAC
TTGTCAAATAGATCCTGAATCCAACAGACAAATGTGAACTATTCTACCACCCTTAAAGTTGGAGCTACCACTTTTAGCATAGATTGCTCA
GCTTGACACTGAAGCATATTATGCAAACAAGCTTTGTTTTAATATAAAGCAATCCCCAAAAGATTTGAGCTTTCAGTTATAAATTTGCAT
CCTTTTCATAATGCCACTGAGTTCAGGGGATGGTCTAACTCATTTCATACTCTGTGAATATTCAAAAGTAATAGAATCTGGCATATAGTT
TTATTGGTTCCTTAGCCATGGGATTATTGAGGCTTTCACATATCAGTGATTTTAAAATATCAGTGTTTTTTGCTACTCATTTGTATGTAT
TCAGTCCTAGGATTTTGAATGGTTTTCTAATATAGTGACATCTGCATTTAATTTCCAGAAATTAAATTAATTTTCATGTTTGAATGCTGT
AATTCCATTTAAATTCCATTTATATACTTTAAGGAAACAAGATTACAACAATTAAAAAAACACATAGTTCCAGTTTCTATGGCCTTCCCA
CCTTCTGTTAGAAATTAGTTTTATCTGGCATTTTTAAACATTTAAAAATTATTAAACATTTAAAAATTAGTTTATTATCAGATATCAGCA
TATGCCTAATAAAACTTATTTTAATAAGCATTTAATTTTCCATAATATGTTACAGCCAAGGCCTATATAATAATTTTGGATTTGTTCAAT
CTTTCTTACAGGCTGTTTTCTATTGTATCAATCATTAGTATCAATCATTAAGTGGAAGTTGAAGAAGGCATCAAACAAAACAAGGATGTT

>102082_102082_8_ZNF430-KCNIP4_ZNF430_chr19_21216990_ENST00000599548_KCNIP4_chr4_20852290_ENST00000447367_length(amino acids)=303AA_BP=107
MENLKSGVYPLKEASGCPGADRNLLVYSFYEKGPLTFRDVAIEFSLEEWQCLDTAQQDLYRKVMLENYRNLVFLAGIAVSKPDLITCLEQ
GKEPWNMKRHAMVDQPPDSVEDELEMATVRHRPEALELLEAQSKFTKKELQILYRGFKNECPSGVVNEETFKEIYSQFFPQGDSTTYAHF
LFNAFDTDHNGAVSFEDFIKGLSILLRGTVQEKLNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKCTYPVLKEDAPRQHVETFFQKMD

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Fusion Gene PPI Analysis for ZNF430-KCNIP4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000035900108237_2500189.0KCND2
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000038214808237_25029.333333333333332226.0KCND2
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000038215008237_25033.333333333333336230.0KCND2
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000038215219237_25054.333333333333336251.0KCND2
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000044736708237_25020.333333333333332217.0KCND2
TgeneKCNIP4chr19:21216990chr4:20852290ENST0000050920708237_2500189.0KCND2


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF430-KCNIP4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF430-KCNIP4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource