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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF430-OR7E24 (FusionGDB2 ID:102083)

Fusion Gene Summary for ZNF430-OR7E24

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF430-OR7E24
Fusion gene ID: 102083
HgeneTgene
Gene symbol

ZNF430

OR7E24

Gene ID

80264

26648

Gene namezinc finger protein 430olfactory receptor family 7 subfamily E member 24
Synonyms-HSHT2|OR19-8|OR7E24P|OR7E24Q
Cytomap

19p12

19p13.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 430olfactory receptor 7E24olfactory receptor OR19-14
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000261560, ENST00000599548, 
ENST00000595401, 		ENST00000456448, 
Fusion gene scores* DoF score6 X 2 X 5=601 X 1 X 1=1
# samples 61
** MAII scorelog2(6/60*10)=0log2(1/1*10)=3.32192809488736
Context

PubMed: ZNF430 [Title/Abstract] AND OR7E24 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF430(21216990)-OR7E24(9361761), # samples:2
Anticipated loss of major functional domain due to fusion event.ZNF430-OR7E24 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ZNF430 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across OR7E24 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCSTCGA-N8-A4PP-01AZNF430chr19

21216990

+OR7E24chr19

9361761

+
ChimerDB4UCSTCGA-N8-A4PPZNF430chr19

21216990

+OR7E24chr19

9361761

+


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Fusion Gene ORF analysis for ZNF430-OR7E24

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000261560ENST00000456448ZNF430chr19

21216990

+OR7E24chr19

9361761

+
Frame-shiftENST00000599548ENST00000456448ZNF430chr19

21216990

+OR7E24chr19

9361761

+
In-frameENST00000595401ENST00000456448ZNF430chr19

21216990

+OR7E24chr19

9361761

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000595401ZNF430chr1921216990+ENST00000456448OR7E24chr199361761+3984292529793902307

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000595401ENST00000456448ZNF430chr1921216990+OR7E24chr199361761+0.0030923310.99690765

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Fusion Genomic Features for ZNF430-OR7E24


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF430-OR7E24


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:21216990/chr19:9361761)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF430chr19:21216990chr19:9361761ENST00000261560+4535_107107571.0DomainKRAB
TgeneOR7E24chr19:21216990chr19:9361761ENST0000045644801139_1570340.0Topological domainCytoplasmic
TgeneOR7E24chr19:21216990chr19:9361761ENST0000045644801179_2150340.0Topological domainExtracellular
TgeneOR7E24chr19:21216990chr19:9361761ENST00000456448011_430340.0Topological domainExtracellular
TgeneOR7E24chr19:21216990chr19:9361761ENST0000045644801236_2550340.0Topological domainCytoplasmic
TgeneOR7E24chr19:21216990chr19:9361761ENST0000045644801277_2890340.0Topological domainExtracellular
TgeneOR7E24chr19:21216990chr19:9361761ENST0000045644801311_3390340.0Topological domainCytoplasmic
TgeneOR7E24chr19:21216990chr19:9361761ENST000004564480165_720340.0Topological domainCytoplasmic
TgeneOR7E24chr19:21216990chr19:9361761ENST000004564480194_1170340.0Topological domainExtracellular
TgeneOR7E24chr19:21216990chr19:9361761ENST0000045644801118_1380340.0TransmembraneHelical%3B Name%3D3
TgeneOR7E24chr19:21216990chr19:9361761ENST0000045644801158_1780340.0TransmembraneHelical%3B Name%3D4
TgeneOR7E24chr19:21216990chr19:9361761ENST0000045644801216_2350340.0TransmembraneHelical%3B Name%3D5
TgeneOR7E24chr19:21216990chr19:9361761ENST0000045644801256_2760340.0TransmembraneHelical%3B Name%3D6
TgeneOR7E24chr19:21216990chr19:9361761ENST0000045644801290_3100340.0TransmembraneHelical%3B Name%3D7
TgeneOR7E24chr19:21216990chr19:9361761ENST000004564480144_640340.0TransmembraneHelical%3B Name%3D1
TgeneOR7E24chr19:21216990chr19:9361761ENST000004564480173_930340.0TransmembraneHelical%3B Name%3D2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF430chr19:21216990chr19:9361761ENST00000261560+45205_227107571.0Zinc fingerC2H2-type 1
HgeneZNF430chr19:21216990chr19:9361761ENST00000261560+45233_255107571.0Zinc fingerC2H2-type 2
HgeneZNF430chr19:21216990chr19:9361761ENST00000261560+45261_283107571.0Zinc fingerC2H2-type 3
HgeneZNF430chr19:21216990chr19:9361761ENST00000261560+45289_311107571.0Zinc fingerC2H2-type 4
HgeneZNF430chr19:21216990chr19:9361761ENST00000261560+45317_339107571.0Zinc fingerC2H2-type 5
HgeneZNF430chr19:21216990chr19:9361761ENST00000261560+45345_367107571.0Zinc fingerC2H2-type 6
HgeneZNF430chr19:21216990chr19:9361761ENST00000261560+45373_395107571.0Zinc fingerC2H2-type 7
HgeneZNF430chr19:21216990chr19:9361761ENST00000261560+45401_423107571.0Zinc fingerC2H2-type 8
HgeneZNF430chr19:21216990chr19:9361761ENST00000261560+45429_451107571.0Zinc fingerC2H2-type 9
HgeneZNF430chr19:21216990chr19:9361761ENST00000261560+45457_479107571.0Zinc fingerC2H2-type 10
HgeneZNF430chr19:21216990chr19:9361761ENST00000261560+45485_507107571.0Zinc fingerC2H2-type 11
HgeneZNF430chr19:21216990chr19:9361761ENST00000261560+45513_535107571.0Zinc fingerC2H2-type 12%3B degenerate


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Fusion Gene Sequence for ZNF430-OR7E24


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>102083_102083_1_ZNF430-OR7E24_ZNF430_chr19_21216990_ENST00000595401_OR7E24_chr19_9361761_ENST00000456448_length(transcript)=3984nt_BP=2925nt
AGAGGTCCAGGCTCTGTGGCCCTGTGACCCGCAGGTATTGGGAGATCTACAGCTAAGACGCCAGGAACCCCTGGAAGCCTAGAAATGGAG
AACCTGAAGTCTGGAGTGTATCCTCTCAAGGAAGCAAGTGGATGCCCTGGGGCTGACAGGAATCTTCTGGTGTACTCTTTTTATGAAAAG
GGGCCATTGACATTTAGGGATGTGGCCATAGAATTTTCTCTGGAGGAGTGGCAATGCCTGGACACTGCTCAGCAGGATTTGTATAGAAAA
GTGATGTTAGAGAACTACAGAAACCTGGTCTTCTTGGGTAGGTGAGAGTGAACACAACAGACGACATGAATGAGAGGTCCAAAAAAGAAG
AAAGCCAATGCTTAAAATGTTATTTGAGAATCTGTGTTCCAAAGCAAATATTTTCTGGGAAGCCTGAGTTTTTTTTTTTAATTTTGCCCT
CGCATAGGGTCATCTTCTGTCTTATGCTTTTAAATTCAAGGATTCTTTCCCCTTGGTGATCTCCCTTCAAGTTTGCTATCAGAACCAAAG
TCCTCTTCATGGCATGCGAGACTCACAATCTGACTGCTTTTCCATTGTTTTGGGGGACACACAAATATCTACATGATTTTGAGAAACTCT
ATGTTAAACTATTTTCTTTTCTTTTTTCTTTCTTTTTTTTTTTTTTTGAGACTGAGTTTCATGCTCGTTGCCCAGGCTAAAGTGCAATGG
CACGATCTAGGCTCACTGCAACCTCTGCCTCCTGGATTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGGTGGAATTACAGGCACCTG
CCACCATGCCCAGTTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGGCAGGCTGGTCTCAAACTCCTGACCTCAAGTG
ATCCACCCGCCTTGGCCTCCCAAAGTACTAGGATTACAGGTGTGAGCCACTGCACCTGGCCAAACTATTTTCTTAGTTCTCTTTTTGCAT
CATGTCTGAAATGTGTAATAGTAGTGGTTTCTGTTCCACTGTTTTTTGTTGTTGTTGTTAACTTTTCTGCACACTCCATTCTGTTCTTAT
TACTATATTCTCGAAATATAGTTTGAAATTATAAAGCATCATGTCTTTCTACTTTGTTCTTTTTCCTCACGATTGCTTTGGCTATTTGAA
GTTTATTGTTGTTTCTTGTAAATTTTAGAATTGTATTTTCCATTACTGTGAAGAAAAATGCCACTGAAATTTTGATAGGGAATTTATTGA
ATCTATAGATTACTTAGATAATAGGACACTTTAACAATATTTATTTTTTCAATCTGTAGACATGCAATATTTTTAAATTTGTGTCTTCTC
TAATTTCTTTTATTAATAACATATCTTTCGTTGTAAAGATTTTTTACTTCCTTGTTCTCAGAAATTTATCATTTTAATGCTATTTTAAAT
TGTTTTCTTTCTCTGTTAAAGTGTATGGAACAATAACTTCATACTTGTGTGTTAATTTTATGTTTTGCTAATTTACTGAGTGTATTAATT
CAGACAAATTTCAATGTAGTGTTCATGGTTTTTTATATATAAAATCATATGATCCACAAACAGCAACTTTTTACTTGTGTTCAATTTCAG
TGGCTTTTTAAAAATGTTTTTGACTCATTATTCTGCCACATACTTCCAGTGCTATGTTAAAATAGAAGCATTGACAATGGGCACAATGTA
GTTTTGCATTAGTGTCTGTGAATTTGAAGGAGCAAACAACTCCTCAAGCTTCTATAAACTGGTTTCAGTAGGTAAAGATCTTTTTCTGTC
ATGTCTCCAGGGTCATAGAATGCTCTCTGGGTTTGTAGTGGAGAGGGGGTGTAGCTTGGTCACAAGGCTGCTGGGTCTGCACTAGGGTCC
ACCTTTAGTTGGCTTGTTACAGGGGCTTGGGTAGTGGTAATTCCCATTTTATTTTTGGACAGACTGAATATCCTTCAACACTTTGATCTG
TAGAGCAGACAATAGGGCAGGTTTCTGCAGTCAGGTTCATATATAATGGTCCTTATATCAGGATGTGAATGAGTATGGCGTTTATTGAGT
ACCGGAGAGGATTACTGTAGTTATGCAGACAAATTCTTTTTTAATGGTATATCAGTGTTGCACAGCAGATTTTATGAGTAAATATGTCAC
TTACTATTACTGCGCAGTTTCATATCAGTGTTTTGTTAGTGTAGGTTTCTTAACATTGAGTTATTGTGTTTTTTTGTTTCACTTTTGTAT
TATAATTTTAGACAGTTTGCAATTCGGTTTATCTCTTATAATTAAGAGATAAATCAGCCATATGTCTGTCACAATTAGATATATATGTGT
GTGTGTGTTTATCTATAAATATGACCCCAATATTGGTTATGGCTTATCTTGTATATATTCTTTCTTAGCCAATTTTCAGTGGTTGTTTTA
TCTCACCTAAGTGAGTAGTCATGGAAATATTTTCACCATCTCTTATTTTCACCATGTGTTTAATGATGATGTTTCTCTCACCTTTGTGTG
AGAGAAACACTTTTGTAATTTGAAGGTAATTTTTGAAAAGATTTATAAATCTGTATTTTTTTCAGTTTTTCCTTTAGAAAAATTAATTGT
TGTAAAAACACATAATATTTACCATCTTAAATCTATTTAGGTGTACCTTTTAGGGCCAGACATGGTGGTGGCTCACATCTGTAATCCAGG
ATTATTTGAGCTCAAAAGTTTGAGACCAACCTGGGAAACATATGGAGAGTCCCTCTCTACAAAATGTTTTTTAAAAATAGCCAGGCATAG
TGTTGTGCATCTGTGGTTCAGGCTACTTGCAAGACTGAGGTGGGAGGGTTACTTGAGCCTCAGAGTTTGAGGCCGAAGTGAGCCATAATT
GTACCACTGCACTCCAGCTTTTTGACAGAGTGAGACTGTGTCTCCTGTCCGAGCTACACAGAGCCACAGAATCTCACAGGTGTCTCAGAA
TTCCTCCTCCTGGGACTCTCAGAGGATCCAGAACTGCAGCCGGTCCTCGCTGGGCTGTTCCTGTCCATGTACCTGGTCACGGTGCTGGGG
AACCTGCTCATCATCCTGGCTGTCAGCTCTGACTCCCACCTCCACACCCCCATGTACTTCTTCCTCTCCAACCTGTCCTTGGCTGACATC
GGTTTCACCTCCACCACGGTCCCCAAGATGATTGTGGACATGCAAACTCACAGCAGAGTCATCTCCTATGAAGGCTGCCTGACTCAGATG
TCTTTTTTTGTCCTTTTTGCATGTATGGATGACATGCTCCTGAGTGTGATGGCCTATGACCGGTTTGTGGCCATCTGTCACCCCCTGCAC
TACCGAATCATCATGAACCCACGCCTCTGTGGCTTCTTAATCTTGTTGTCTTTTTTTATTAGTCTTTTGGACTCCCAGTTGCACAATTTG
ATTATGTTACAGCTCACCTGCTTCAAGGATGTGGACATTTCTAATTTCTTCTGTGACCCTTCTCAACTCCTCCACCTTAGGTGTTCCGAC
ACCTTCATCAATGAAATGGTCATATATTTCATGGGTGCCATATTTGGCTGTCTCCCTATCTCAGGGATCCTTTTCTCTTACTATAAAATT
GTTTCCCCCATTCTGAGAGTTCCAACATCAGATGGGAAGTATAAAGCCTTCTCCACCTGTGGCTCTCACCTGGCAGTTGTTTGCTTATTT
TATGGAACAGGGCTTGTAGGGTACCTCAGTTCAGCTGTGTTACCATCCCCCAGGAAGAGTATGGTGGCTTCAGTGATGTACACTGTGGTC
ACCCCCATGCTGAACCCCTTCATCTACAGCCTGAGGAACAAGGACATTCAAAGTGCCCTGTGCAGGCTGCATGGCAGAATCATCAAATCT
CATCATCTCCATCCTTTTTGTTATATGGGATAGAAATGGCAGCAAAATTTAACACCTAGGCCTGCAAATTCTGCCTCCTTGGTCACATTA

>102083_102083_1_ZNF430-OR7E24_ZNF430_chr19_21216990_ENST00000595401_OR7E24_chr19_9361761_ENST00000456448_length(amino acids)=307AA_BP=1
MGLSEDPELQPVLAGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSLADIGFTSTTVPKMIVDMQTHSRVISYEGCLTQMSFF
VLFACMDDMLLSVMAYDRFVAICHPLHYRIIMNPRLCGFLILLSFFISLLDSQLHNLIMLQLTCFKDVDISNFFCDPSQLLHLRCSDTFI
NEMVIYFMGAIFGCLPISGILFSYYKIVSPILRVPTSDGKYKAFSTCGSHLAVVCLFYGTGLVGYLSSAVLPSPRKSMVASVMYTVVTPM

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Fusion Gene PPI Analysis for ZNF430-OR7E24


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF430-OR7E24


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF430-OR7E24


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource