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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF431-SKAP2 (FusionGDB2 ID:102090)

Fusion Gene Summary for ZNF431-SKAP2

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF431-SKAP2
Fusion gene ID: 102090
HgeneTgene
Gene symbol

ZNF431

SKAP2

Gene ID

170959

8935

Gene namezinc finger protein 431src kinase associated phosphoprotein 2
Synonyms-PRAP|RA70|SAPS|SCAP2|SKAP-HOM|SKAP55R
Cytomap

19p12

7p15.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 431src kinase-associated phosphoprotein 2Fyn-associated phosphoprotein SKAP55 homologuePyk2/RAFTK-associated proteinSKAP-55HOMSKAP55 homologretinoic acid-induced protein 70src family-associated phosphoprotein 2src kinase-associated phosphoprotein of 5
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000311048, ENST00000599296, 
ENST00000600692, ENST00000594425, 
ENST00000594821, 		ENST00000539623, 
ENST00000489977, ENST00000345317, 
Fusion gene scores* DoF score6 X 3 X 5=9010 X 9 X 7=630
# samples 613
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/630*10)=-2.27684020535882
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF431 [Title/Abstract] AND SKAP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF431(21350469)-SKAP2(26883756), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ZNF431 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SKAP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-69-7763-01AZNF431chr19

21350469

+SKAP2chr7

26883756

-


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Fusion Gene ORF analysis for ZNF431-SKAP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000311048ENST00000539623ZNF431chr19

21350469

+SKAP2chr7

26883756

-
5CDS-5UTRENST00000599296ENST00000539623ZNF431chr19

21350469

+SKAP2chr7

26883756

-
5CDS-5UTRENST00000600692ENST00000539623ZNF431chr19

21350469

+SKAP2chr7

26883756

-
5CDS-intronENST00000311048ENST00000489977ZNF431chr19

21350469

+SKAP2chr7

26883756

-
5CDS-intronENST00000599296ENST00000489977ZNF431chr19

21350469

+SKAP2chr7

26883756

-
5CDS-intronENST00000600692ENST00000489977ZNF431chr19

21350469

+SKAP2chr7

26883756

-
In-frameENST00000311048ENST00000345317ZNF431chr19

21350469

+SKAP2chr7

26883756

-
In-frameENST00000599296ENST00000345317ZNF431chr19

21350469

+SKAP2chr7

26883756

-
In-frameENST00000600692ENST00000345317ZNF431chr19

21350469

+SKAP2chr7

26883756

-
intron-3CDSENST00000594425ENST00000345317ZNF431chr19

21350469

+SKAP2chr7

26883756

-
intron-3CDSENST00000594821ENST00000345317ZNF431chr19

21350469

+SKAP2chr7

26883756

-
intron-5UTRENST00000594425ENST00000539623ZNF431chr19

21350469

+SKAP2chr7

26883756

-
intron-5UTRENST00000594821ENST00000539623ZNF431chr19

21350469

+SKAP2chr7

26883756

-
intron-intronENST00000594425ENST00000489977ZNF431chr19

21350469

+SKAP2chr7

26883756

-
intron-intronENST00000594821ENST00000489977ZNF431chr19

21350469

+SKAP2chr7

26883756

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000600692ZNF431chr1921350469+ENST00000345317SKAP2chr726883756-39644791601359399
ENST00000599296ZNF431chr1921350469+ENST00000345317SKAP2chr726883756-39534681491348399
ENST00000311048ZNF431chr1921350469+ENST00000345317SKAP2chr726883756-39484631441343399

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000600692ENST00000345317ZNF431chr1921350469+SKAP2chr726883756-0.000144720.9998553
ENST00000599296ENST00000345317ZNF431chr1921350469+SKAP2chr726883756-0.0001469470.999853
ENST00000311048ENST00000345317ZNF431chr1921350469+SKAP2chr726883756-0.0001477720.9998522

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Fusion Genomic Features for ZNF431-SKAP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF431-SKAP2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:21350469/chr7:26883756)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF431chr19:21350469chr7:26883756ENST00000311048+4535_106106577.0DomainKRAB
TgeneSKAP2chr19:21350469chr7:26883756ENST00000345317213116_219661096.6666666666667DomainPH
TgeneSKAP2chr19:21350469chr7:26883756ENST00000345317213297_358661096.6666666666667DomainSH3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF431chr19:21350469chr7:26883756ENST00000311048+45176_198106577.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF431chr19:21350469chr7:26883756ENST00000311048+45204_226106577.0Zinc fingerC2H2-type 2
HgeneZNF431chr19:21350469chr7:26883756ENST00000311048+45232_254106577.0Zinc fingerC2H2-type 3
HgeneZNF431chr19:21350469chr7:26883756ENST00000311048+45260_282106577.0Zinc fingerC2H2-type 4
HgeneZNF431chr19:21350469chr7:26883756ENST00000311048+45288_310106577.0Zinc fingerC2H2-type 5
HgeneZNF431chr19:21350469chr7:26883756ENST00000311048+45316_338106577.0Zinc fingerC2H2-type 6
HgeneZNF431chr19:21350469chr7:26883756ENST00000311048+45344_366106577.0Zinc fingerC2H2-type 7
HgeneZNF431chr19:21350469chr7:26883756ENST00000311048+45372_394106577.0Zinc fingerC2H2-type 8
HgeneZNF431chr19:21350469chr7:26883756ENST00000311048+45400_422106577.0Zinc fingerC2H2-type 9
HgeneZNF431chr19:21350469chr7:26883756ENST00000311048+45428_450106577.0Zinc fingerC2H2-type 10
HgeneZNF431chr19:21350469chr7:26883756ENST00000311048+45456_478106577.0Zinc fingerC2H2-type 11
HgeneZNF431chr19:21350469chr7:26883756ENST00000311048+45484_506106577.0Zinc fingerC2H2-type 12
HgeneZNF431chr19:21350469chr7:26883756ENST00000311048+45512_534106577.0Zinc fingerC2H2-type 13
TgeneSKAP2chr19:21350469chr7:26883756ENST0000034531721314_64661096.6666666666667RegionHomodimerization


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Fusion Gene Sequence for ZNF431-SKAP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>102090_102090_1_ZNF431-SKAP2_ZNF431_chr19_21350469_ENST00000311048_SKAP2_chr7_26883756_ENST00000345317_length(transcript)=3948nt_BP=463nt
GTCTCTCGCCGCAGCCTGAGCTCCAGGTCTCCCCTTCGCTGCTCTGTGTCCTCTGCTCCTAGAGGCCCAACATCTGTGGCCCTGTGACCT
GCAGGTATTGGGAGACCCACAGCTAAGACACCGGGACCCCCTGAAAGCCTAGAAATGGACGACTTGAAATATGGAGTGTATCCTCTCAAG
GAAGCAAGTGGATGCCCTGGGGCTGAGAGGAATCTTCTAGTTTACTCTTATTTTGAAAAGGAGACATTGACATTTAGGGATGTGGCCATA
GAATTCTCTCTGGAGGAGTGGGAATGCCTGAACCCTGCTCAGCAGAATTTATATATGAATGTGATGTTAGAAAACTACAAAAACCTGGTC
TTCTTGGGTGTTGCTGTCTCTAAGCAAGACCCAGTCACCTGTCTGGAGCAAGAAAAAGAGCCCTGGAATATGAAGAGACATGAGATGGTG
GATGAACCCCCAGGTGATGCAGAAGATGGGGAAGAATATGATGACCCTTTTGCTGGGCCTCCAGACACTATTTCATTAGCCTCAGAACGA
TATGATAAAGACGATGAAGCCCCCTCTGATGGAGCCCAGTTTCCTCCAATTGCAGCACAAGACCTTCCTTTTGTTCTAAAGGCTGGCTAC
CTTGAAAAACGCAGAAAAGATCACAGCTTTCTGGGATTTGAATGGCAGAAACGGTGGTGTGCTCTCAGTAAAACGGTATTCTATTATTAT
GGAAGTGATAAAGACAAACAACAGAAAGGTGAATTTGCAATAGATGGCTACAGTGTCAGAATGAATAACACTCTAAGAAAGGATGGAAAG
AAAGATTGCTGTTTTGAAATCTCTGCTCCTGATAAACGTATATATCAGTTTACAGCAGCTTCTCCCAAAGATGCTGAAGAATGGGTACAG
CAGCTGAAATTTGTATTGCAAGATATGGAATCTGATATTATTCCTGAGGATTATGATGAGAGAGGAGAATTATATGATGATGTTGATCAT
CCTCTACCAATAAGCAATCCACTAACAAGCAGTCAACCAATAGATGATGAAATTTATGAAGAACTTCCAGAAGAAGAAGAGGACAGTGCT
CCAGTGAAAGTGGAAGAACAAAGGAAGATGAGTCAGGATAGTGTCCATCACACCTCAGGGGATAAGAGCACTGATTATGCTAATTTTTAC
CAGGGATTGTGGGATTGTACTGGAGCTTTTTCTGATGAGTTGTCATTTAAGCGTGGTGATGTGATTTACATTCTTAGCAAGGAATACAAT
AGATATGGCTGGTGGGTAGGAGAAATGAAGGGAGCCATTGGCTTGGTGCCTAAAGCCTACATAATGGAGATGTATGATATTTGAGAGTCC
TGGAAAAGGAAAATTCTTCTGCTTGTCTGCAAATGCTTTGGATTTAGAAGCGTCATGAAAGCACGAGTGACAGCTCCTAACCTCTCCTTG
TTTTATTAAACATTACTTATCTTTGACTGTTATTTTATGCAGTCGCTCATTAAAATATTCCTCTGATGTGAAATTAAATGAAGGATATTA
ATGTAAATTAGATGCAACCAGTTAAGTTATACCTGTTGCTATTTTGCAAAGAAATAATTATAGTTTTTATTTACCCATTTGATTTGTGTG
AAGAATTCATCACTATTTTATACGTAACATATAGTCTACTATAGCATAGTATGCTACTATTGCTACTTCTGGTGTGATTTGTAATGTTTC
TTAATCATTGGACATCAATTATTTTTAGAGAGTAATGTATAATTTCATAGCATTTTAAATTTAGTGTATCATGCGAGTTTTTTTTGGTAG
ATGCTGAAGAATGTGGTTGCTAAACAAAGAATGCTAAAGAATGTTCAAACTTTATAGATAACTTTATTGTTATTATTTATTTTCACACAT
TTAATTCCTATTAAGTACAGCCGCAAGAAAGAAAAAATGATGAAGTTGCAAATGGCAGTGTGCTGTCACCTGCAACAGAAGTGCGTACCA
GAAGTATGACTCATGCAAAGCATTTTACCGTACAAATATCCTGGTGCGATGATGGGCCTGGCAACATTTTCTACTGTACTTTTGTTTAAA
TTTAATGAAACAAAAAATTCCTAAGAAATACCACCCTACCACTAACAAAATGGTATAAAGAATCTCCCAGCCAGGCCAACATGGTGAAAC
CCTGTCTCTACTAAAAATTAGCCAAGTGTGGTAATGTTCACCTGCAGTCCCAGCTACTTGGGAGGCCAAGGCACGAGAATTGCTTGAACA
AGGTAGGCAGAGGTTGCAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTGGGCGACAGAGTGAGACTCCATCTCAGAAAAAAAAAAAA
AAAAAAACAGAATCTCAGTGTATTCTCAAAGTAAAAAGGCATAACCAAGCACTCTCTTATCTTGCCTTATTGCTATACTATTTACATCCC
ACTGCAGAACAGCAGATTTGAGGCTTTTCTATATACTTCTCAGAGCACTGAAAAGAAAGGAAGGGTTTGCAGAGGAGAGTGTAGAAATCC
CAGTGGTAGCATGTACCAACAGGTGAGTAGAAAGGTAGTGTTAGCCTGACATTTGAGTTATACTCTGTGCTGCCTGAGCAAGATTTGTAG
AATCATATAATTACCTTTTCATGTATATTTGAAATCAGAGGTGTTTAAAATACCTATGAGATACCAATGTAGCCTTAACATATGTCAAAA
TGCATTGCTGGTTAGATAATTATTTGGACTACACATAAACTCCTAATATTGAATCATTACCTATCAGGTATTATCTTTATGGAACTTTTC
AATATCTTTGCTTTATAAAGATTCTAAACATGTATCTGAGCTGGTAATATTTTAAAATCTCCATTATTTGTGTAAAACTGTTTATAAGCA
GTGTTTGAGAGGGTCTGCTTTACCATTACCCCCTCAATATCATGATCATCCAATCTCAAATGTGAAAAAAAAAAAGAAATTTGATTTTAG
GGATTGTGAGTAAACAAGTTTATATAGAGAGACATTGTGAAGTTAAAGTTTTCAGAAGTTACATTTGTGCAGTTCTTACCTTTTCCTCAT
ATAGTGCCATTGAAATAGACTGAAATTATCTTGGCAAAAGTTAGACAACCAAAGACGACTTTAGTGGACTGGTTTTCAAAACTTGAGCAG
CTGAAAAGCAAAAGCCGTTGTTTCCCATGACAATGTAGCCTTTGTGGATTTGGGTTTGTGCTTTGGGTTGAAAAGAAGTTTTTAGTCCTA
GGCCAGTAGATGGCAGCAGCTTTTCATTGCAGACAAAACCTCTTGAAACCCTTCCCCCATGGCACAAACTCGCCCATGATGGAAAGCATC
TAGATTTCTGCCTCCTTTTACAGTTAATCCAGGAGAGGGAGTCCTTTGCCAACTGATGACCAACAGTTCCAAGCCAGATAGTCTCGTGAA
CAGTGACAATACAGAAATAAGGTGTTATTTCTGTTCAGATCTCCACCGGCCTTTGTTCTTTTAAAACTTGAATATAGGTGGGAGACATAA
GAAAGGAAAGAAAAGACTTAAAACTGGAGTGACAGGACAAATAATCATTACTTTCAATTCATGACTGCTTTATATTCATTTGATGAAATC
ATTTGTATACAAACCAGGGAGAGTTTTCTTTACACCCTTGACAATATATCACATACTCTTCAAGATCATAATAATATCATTAATATAAAT
TTAAACAACATGGCTTGTTAGAAAATATGCTAATTGCTATGGTCTCATTATGTTTGCTTAGCTTTTATTTGTTTTTCTGTGAACAGTTAG
AGAGCTAATTTTTTTCAAAGGTGATTGTAAGTCATATTTTATATAGCATTTTGCTTGATTATTTGCTCTGTACTGAATTTGTACTCTATT

>102090_102090_1_ZNF431-SKAP2_ZNF431_chr19_21350469_ENST00000311048_SKAP2_chr7_26883756_ENST00000345317_length(amino acids)=399AA_BP=106
MDDLKYGVYPLKEASGCPGAERNLLVYSYFEKETLTFRDVAIEFSLEEWECLNPAQQNLYMNVMLENYKNLVFLGVAVSKQDPVTCLEQE
KEPWNMKRHEMVDEPPGDAEDGEEYDDPFAGPPDTISLASERYDKDDEAPSDGAQFPPIAAQDLPFVLKAGYLEKRRKDHSFLGFEWQKR
WCALSKTVFYYYGSDKDKQQKGEFAIDGYSVRMNNTLRKDGKKDCCFEISAPDKRIYQFTAASPKDAEEWVQQLKFVLQDMESDIIPEDY
DERGELYDDVDHPLPISNPLTSSQPIDDEIYEELPEEEEDSAPVKVEEQRKMSQDSVHHTSGDKSTDYANFYQGLWDCTGAFSDELSFKR

--------------------------------------------------------------
>102090_102090_2_ZNF431-SKAP2_ZNF431_chr19_21350469_ENST00000599296_SKAP2_chr7_26883756_ENST00000345317_length(transcript)=3953nt_BP=468nt
CCTTTGTCTCTCGCCGCAGCCTGAGCTCCAGGTCTCCCCTTCGCTGCTCTGTGTCCTCTGCTCCTAGAGGCCCAACATCTGTGGCCCTGT
GACCTGCAGGTATTGGGAGACCCACAGCTAAGACACCGGGACCCCCTGAAAGCCTAGAAATGGACGACTTGAAATATGGAGTGTATCCTC
TCAAGGAAGCAAGTGGATGCCCTGGGGCTGAGAGGAATCTTCTAGTTTACTCTTATTTTGAAAAGGAGACATTGACATTTAGGGATGTGG
CCATAGAATTCTCTCTGGAGGAGTGGGAATGCCTGAACCCTGCTCAGCAGAATTTATATATGAATGTGATGTTAGAAAACTACAAAAACC
TGGTCTTCTTGGGTGTTGCTGTCTCTAAGCAAGACCCAGTCACCTGTCTGGAGCAAGAAAAAGAGCCCTGGAATATGAAGAGACATGAGA
TGGTGGATGAACCCCCAGGTGATGCAGAAGATGGGGAAGAATATGATGACCCTTTTGCTGGGCCTCCAGACACTATTTCATTAGCCTCAG
AACGATATGATAAAGACGATGAAGCCCCCTCTGATGGAGCCCAGTTTCCTCCAATTGCAGCACAAGACCTTCCTTTTGTTCTAAAGGCTG
GCTACCTTGAAAAACGCAGAAAAGATCACAGCTTTCTGGGATTTGAATGGCAGAAACGGTGGTGTGCTCTCAGTAAAACGGTATTCTATT
ATTATGGAAGTGATAAAGACAAACAACAGAAAGGTGAATTTGCAATAGATGGCTACAGTGTCAGAATGAATAACACTCTAAGAAAGGATG
GAAAGAAAGATTGCTGTTTTGAAATCTCTGCTCCTGATAAACGTATATATCAGTTTACAGCAGCTTCTCCCAAAGATGCTGAAGAATGGG
TACAGCAGCTGAAATTTGTATTGCAAGATATGGAATCTGATATTATTCCTGAGGATTATGATGAGAGAGGAGAATTATATGATGATGTTG
ATCATCCTCTACCAATAAGCAATCCACTAACAAGCAGTCAACCAATAGATGATGAAATTTATGAAGAACTTCCAGAAGAAGAAGAGGACA
GTGCTCCAGTGAAAGTGGAAGAACAAAGGAAGATGAGTCAGGATAGTGTCCATCACACCTCAGGGGATAAGAGCACTGATTATGCTAATT
TTTACCAGGGATTGTGGGATTGTACTGGAGCTTTTTCTGATGAGTTGTCATTTAAGCGTGGTGATGTGATTTACATTCTTAGCAAGGAAT
ACAATAGATATGGCTGGTGGGTAGGAGAAATGAAGGGAGCCATTGGCTTGGTGCCTAAAGCCTACATAATGGAGATGTATGATATTTGAG
AGTCCTGGAAAAGGAAAATTCTTCTGCTTGTCTGCAAATGCTTTGGATTTAGAAGCGTCATGAAAGCACGAGTGACAGCTCCTAACCTCT
CCTTGTTTTATTAAACATTACTTATCTTTGACTGTTATTTTATGCAGTCGCTCATTAAAATATTCCTCTGATGTGAAATTAAATGAAGGA
TATTAATGTAAATTAGATGCAACCAGTTAAGTTATACCTGTTGCTATTTTGCAAAGAAATAATTATAGTTTTTATTTACCCATTTGATTT
GTGTGAAGAATTCATCACTATTTTATACGTAACATATAGTCTACTATAGCATAGTATGCTACTATTGCTACTTCTGGTGTGATTTGTAAT
GTTTCTTAATCATTGGACATCAATTATTTTTAGAGAGTAATGTATAATTTCATAGCATTTTAAATTTAGTGTATCATGCGAGTTTTTTTT
GGTAGATGCTGAAGAATGTGGTTGCTAAACAAAGAATGCTAAAGAATGTTCAAACTTTATAGATAACTTTATTGTTATTATTTATTTTCA
CACATTTAATTCCTATTAAGTACAGCCGCAAGAAAGAAAAAATGATGAAGTTGCAAATGGCAGTGTGCTGTCACCTGCAACAGAAGTGCG
TACCAGAAGTATGACTCATGCAAAGCATTTTACCGTACAAATATCCTGGTGCGATGATGGGCCTGGCAACATTTTCTACTGTACTTTTGT
TTAAATTTAATGAAACAAAAAATTCCTAAGAAATACCACCCTACCACTAACAAAATGGTATAAAGAATCTCCCAGCCAGGCCAACATGGT
GAAACCCTGTCTCTACTAAAAATTAGCCAAGTGTGGTAATGTTCACCTGCAGTCCCAGCTACTTGGGAGGCCAAGGCACGAGAATTGCTT
GAACAAGGTAGGCAGAGGTTGCAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTGGGCGACAGAGTGAGACTCCATCTCAGAAAAAAA
AAAAAAAAAAAACAGAATCTCAGTGTATTCTCAAAGTAAAAAGGCATAACCAAGCACTCTCTTATCTTGCCTTATTGCTATACTATTTAC
ATCCCACTGCAGAACAGCAGATTTGAGGCTTTTCTATATACTTCTCAGAGCACTGAAAAGAAAGGAAGGGTTTGCAGAGGAGAGTGTAGA
AATCCCAGTGGTAGCATGTACCAACAGGTGAGTAGAAAGGTAGTGTTAGCCTGACATTTGAGTTATACTCTGTGCTGCCTGAGCAAGATT
TGTAGAATCATATAATTACCTTTTCATGTATATTTGAAATCAGAGGTGTTTAAAATACCTATGAGATACCAATGTAGCCTTAACATATGT
CAAAATGCATTGCTGGTTAGATAATTATTTGGACTACACATAAACTCCTAATATTGAATCATTACCTATCAGGTATTATCTTTATGGAAC
TTTTCAATATCTTTGCTTTATAAAGATTCTAAACATGTATCTGAGCTGGTAATATTTTAAAATCTCCATTATTTGTGTAAAACTGTTTAT
AAGCAGTGTTTGAGAGGGTCTGCTTTACCATTACCCCCTCAATATCATGATCATCCAATCTCAAATGTGAAAAAAAAAAAGAAATTTGAT
TTTAGGGATTGTGAGTAAACAAGTTTATATAGAGAGACATTGTGAAGTTAAAGTTTTCAGAAGTTACATTTGTGCAGTTCTTACCTTTTC
CTCATATAGTGCCATTGAAATAGACTGAAATTATCTTGGCAAAAGTTAGACAACCAAAGACGACTTTAGTGGACTGGTTTTCAAAACTTG
AGCAGCTGAAAAGCAAAAGCCGTTGTTTCCCATGACAATGTAGCCTTTGTGGATTTGGGTTTGTGCTTTGGGTTGAAAAGAAGTTTTTAG
TCCTAGGCCAGTAGATGGCAGCAGCTTTTCATTGCAGACAAAACCTCTTGAAACCCTTCCCCCATGGCACAAACTCGCCCATGATGGAAA
GCATCTAGATTTCTGCCTCCTTTTACAGTTAATCCAGGAGAGGGAGTCCTTTGCCAACTGATGACCAACAGTTCCAAGCCAGATAGTCTC
GTGAACAGTGACAATACAGAAATAAGGTGTTATTTCTGTTCAGATCTCCACCGGCCTTTGTTCTTTTAAAACTTGAATATAGGTGGGAGA
CATAAGAAAGGAAAGAAAAGACTTAAAACTGGAGTGACAGGACAAATAATCATTACTTTCAATTCATGACTGCTTTATATTCATTTGATG
AAATCATTTGTATACAAACCAGGGAGAGTTTTCTTTACACCCTTGACAATATATCACATACTCTTCAAGATCATAATAATATCATTAATA
TAAATTTAAACAACATGGCTTGTTAGAAAATATGCTAATTGCTATGGTCTCATTATGTTTGCTTAGCTTTTATTTGTTTTTCTGTGAACA
GTTAGAGAGCTAATTTTTTTCAAAGGTGATTGTAAGTCATATTTTATATAGCATTTTGCTTGATTATTTGCTCTGTACTGAATTTGTACT

>102090_102090_2_ZNF431-SKAP2_ZNF431_chr19_21350469_ENST00000599296_SKAP2_chr7_26883756_ENST00000345317_length(amino acids)=399AA_BP=106
MDDLKYGVYPLKEASGCPGAERNLLVYSYFEKETLTFRDVAIEFSLEEWECLNPAQQNLYMNVMLENYKNLVFLGVAVSKQDPVTCLEQE
KEPWNMKRHEMVDEPPGDAEDGEEYDDPFAGPPDTISLASERYDKDDEAPSDGAQFPPIAAQDLPFVLKAGYLEKRRKDHSFLGFEWQKR
WCALSKTVFYYYGSDKDKQQKGEFAIDGYSVRMNNTLRKDGKKDCCFEISAPDKRIYQFTAASPKDAEEWVQQLKFVLQDMESDIIPEDY
DERGELYDDVDHPLPISNPLTSSQPIDDEIYEELPEEEEDSAPVKVEEQRKMSQDSVHHTSGDKSTDYANFYQGLWDCTGAFSDELSFKR

--------------------------------------------------------------
>102090_102090_3_ZNF431-SKAP2_ZNF431_chr19_21350469_ENST00000600692_SKAP2_chr7_26883756_ENST00000345317_length(transcript)=3964nt_BP=479nt
ATGTGGCGGGGCCTTTGTCTCTCGCCGCAGCCTGAGCTCCAGGTCTCCCCTTCGCTGCTCTGTGTCCTCTGCTCCTAGAGGCCCAACATC
TGTGGCCCTGTGACCTGCAGGTATTGGGAGACCCACAGCTAAGACACCGGGACCCCCTGAAAGCCTAGAAATGGACGACTTGAAATATGG
AGTGTATCCTCTCAAGGAAGCAAGTGGATGCCCTGGGGCTGAGAGGAATCTTCTAGTTTACTCTTATTTTGAAAAGGAGACATTGACATT
TAGGGATGTGGCCATAGAATTCTCTCTGGAGGAGTGGGAATGCCTGAACCCTGCTCAGCAGAATTTATATATGAATGTGATGTTAGAAAA
CTACAAAAACCTGGTCTTCTTGGGTGTTGCTGTCTCTAAGCAAGACCCAGTCACCTGTCTGGAGCAAGAAAAAGAGCCCTGGAATATGAA
GAGACATGAGATGGTGGATGAACCCCCAGGTGATGCAGAAGATGGGGAAGAATATGATGACCCTTTTGCTGGGCCTCCAGACACTATTTC
ATTAGCCTCAGAACGATATGATAAAGACGATGAAGCCCCCTCTGATGGAGCCCAGTTTCCTCCAATTGCAGCACAAGACCTTCCTTTTGT
TCTAAAGGCTGGCTACCTTGAAAAACGCAGAAAAGATCACAGCTTTCTGGGATTTGAATGGCAGAAACGGTGGTGTGCTCTCAGTAAAAC
GGTATTCTATTATTATGGAAGTGATAAAGACAAACAACAGAAAGGTGAATTTGCAATAGATGGCTACAGTGTCAGAATGAATAACACTCT
AAGAAAGGATGGAAAGAAAGATTGCTGTTTTGAAATCTCTGCTCCTGATAAACGTATATATCAGTTTACAGCAGCTTCTCCCAAAGATGC
TGAAGAATGGGTACAGCAGCTGAAATTTGTATTGCAAGATATGGAATCTGATATTATTCCTGAGGATTATGATGAGAGAGGAGAATTATA
TGATGATGTTGATCATCCTCTACCAATAAGCAATCCACTAACAAGCAGTCAACCAATAGATGATGAAATTTATGAAGAACTTCCAGAAGA
AGAAGAGGACAGTGCTCCAGTGAAAGTGGAAGAACAAAGGAAGATGAGTCAGGATAGTGTCCATCACACCTCAGGGGATAAGAGCACTGA
TTATGCTAATTTTTACCAGGGATTGTGGGATTGTACTGGAGCTTTTTCTGATGAGTTGTCATTTAAGCGTGGTGATGTGATTTACATTCT
TAGCAAGGAATACAATAGATATGGCTGGTGGGTAGGAGAAATGAAGGGAGCCATTGGCTTGGTGCCTAAAGCCTACATAATGGAGATGTA
TGATATTTGAGAGTCCTGGAAAAGGAAAATTCTTCTGCTTGTCTGCAAATGCTTTGGATTTAGAAGCGTCATGAAAGCACGAGTGACAGC
TCCTAACCTCTCCTTGTTTTATTAAACATTACTTATCTTTGACTGTTATTTTATGCAGTCGCTCATTAAAATATTCCTCTGATGTGAAAT
TAAATGAAGGATATTAATGTAAATTAGATGCAACCAGTTAAGTTATACCTGTTGCTATTTTGCAAAGAAATAATTATAGTTTTTATTTAC
CCATTTGATTTGTGTGAAGAATTCATCACTATTTTATACGTAACATATAGTCTACTATAGCATAGTATGCTACTATTGCTACTTCTGGTG
TGATTTGTAATGTTTCTTAATCATTGGACATCAATTATTTTTAGAGAGTAATGTATAATTTCATAGCATTTTAAATTTAGTGTATCATGC
GAGTTTTTTTTGGTAGATGCTGAAGAATGTGGTTGCTAAACAAAGAATGCTAAAGAATGTTCAAACTTTATAGATAACTTTATTGTTATT
ATTTATTTTCACACATTTAATTCCTATTAAGTACAGCCGCAAGAAAGAAAAAATGATGAAGTTGCAAATGGCAGTGTGCTGTCACCTGCA
ACAGAAGTGCGTACCAGAAGTATGACTCATGCAAAGCATTTTACCGTACAAATATCCTGGTGCGATGATGGGCCTGGCAACATTTTCTAC
TGTACTTTTGTTTAAATTTAATGAAACAAAAAATTCCTAAGAAATACCACCCTACCACTAACAAAATGGTATAAAGAATCTCCCAGCCAG
GCCAACATGGTGAAACCCTGTCTCTACTAAAAATTAGCCAAGTGTGGTAATGTTCACCTGCAGTCCCAGCTACTTGGGAGGCCAAGGCAC
GAGAATTGCTTGAACAAGGTAGGCAGAGGTTGCAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTGGGCGACAGAGTGAGACTCCATC
TCAGAAAAAAAAAAAAAAAAAAACAGAATCTCAGTGTATTCTCAAAGTAAAAAGGCATAACCAAGCACTCTCTTATCTTGCCTTATTGCT
ATACTATTTACATCCCACTGCAGAACAGCAGATTTGAGGCTTTTCTATATACTTCTCAGAGCACTGAAAAGAAAGGAAGGGTTTGCAGAG
GAGAGTGTAGAAATCCCAGTGGTAGCATGTACCAACAGGTGAGTAGAAAGGTAGTGTTAGCCTGACATTTGAGTTATACTCTGTGCTGCC
TGAGCAAGATTTGTAGAATCATATAATTACCTTTTCATGTATATTTGAAATCAGAGGTGTTTAAAATACCTATGAGATACCAATGTAGCC
TTAACATATGTCAAAATGCATTGCTGGTTAGATAATTATTTGGACTACACATAAACTCCTAATATTGAATCATTACCTATCAGGTATTAT
CTTTATGGAACTTTTCAATATCTTTGCTTTATAAAGATTCTAAACATGTATCTGAGCTGGTAATATTTTAAAATCTCCATTATTTGTGTA
AAACTGTTTATAAGCAGTGTTTGAGAGGGTCTGCTTTACCATTACCCCCTCAATATCATGATCATCCAATCTCAAATGTGAAAAAAAAAA
AGAAATTTGATTTTAGGGATTGTGAGTAAACAAGTTTATATAGAGAGACATTGTGAAGTTAAAGTTTTCAGAAGTTACATTTGTGCAGTT
CTTACCTTTTCCTCATATAGTGCCATTGAAATAGACTGAAATTATCTTGGCAAAAGTTAGACAACCAAAGACGACTTTAGTGGACTGGTT
TTCAAAACTTGAGCAGCTGAAAAGCAAAAGCCGTTGTTTCCCATGACAATGTAGCCTTTGTGGATTTGGGTTTGTGCTTTGGGTTGAAAA
GAAGTTTTTAGTCCTAGGCCAGTAGATGGCAGCAGCTTTTCATTGCAGACAAAACCTCTTGAAACCCTTCCCCCATGGCACAAACTCGCC
CATGATGGAAAGCATCTAGATTTCTGCCTCCTTTTACAGTTAATCCAGGAGAGGGAGTCCTTTGCCAACTGATGACCAACAGTTCCAAGC
CAGATAGTCTCGTGAACAGTGACAATACAGAAATAAGGTGTTATTTCTGTTCAGATCTCCACCGGCCTTTGTTCTTTTAAAACTTGAATA
TAGGTGGGAGACATAAGAAAGGAAAGAAAAGACTTAAAACTGGAGTGACAGGACAAATAATCATTACTTTCAATTCATGACTGCTTTATA
TTCATTTGATGAAATCATTTGTATACAAACCAGGGAGAGTTTTCTTTACACCCTTGACAATATATCACATACTCTTCAAGATCATAATAA
TATCATTAATATAAATTTAAACAACATGGCTTGTTAGAAAATATGCTAATTGCTATGGTCTCATTATGTTTGCTTAGCTTTTATTTGTTT
TTCTGTGAACAGTTAGAGAGCTAATTTTTTTCAAAGGTGATTGTAAGTCATATTTTATATAGCATTTTGCTTGATTATTTGCTCTGTACT
GAATTTGTACTCTATTGCCATTAGATCTTACAATAATGTTCCACTCTGCAAATTTTTAAGGTTCAAATAAAGTTTAATTGTTTGCAAACT

>102090_102090_3_ZNF431-SKAP2_ZNF431_chr19_21350469_ENST00000600692_SKAP2_chr7_26883756_ENST00000345317_length(amino acids)=399AA_BP=106
MDDLKYGVYPLKEASGCPGAERNLLVYSYFEKETLTFRDVAIEFSLEEWECLNPAQQNLYMNVMLENYKNLVFLGVAVSKQDPVTCLEQE
KEPWNMKRHEMVDEPPGDAEDGEEYDDPFAGPPDTISLASERYDKDDEAPSDGAQFPPIAAQDLPFVLKAGYLEKRRKDHSFLGFEWQKR
WCALSKTVFYYYGSDKDKQQKGEFAIDGYSVRMNNTLRKDGKKDCCFEISAPDKRIYQFTAASPKDAEEWVQQLKFVLQDMESDIIPEDY
DERGELYDDVDHPLPISNPLTSSQPIDDEIYEELPEEEEDSAPVKVEEQRKMSQDSVHHTSGDKSTDYANFYQGLWDCTGAFSDELSFKR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZNF431-SKAP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF431-SKAP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF431-SKAP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource