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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF432-COL6A1 (FusionGDB2 ID:102092)

Fusion Gene Summary for ZNF432-COL6A1

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF432-COL6A1
Fusion gene ID: 102092
HgeneTgene
Gene symbol

ZNF432

COL6A1

Gene ID

9668

1291

Gene namezinc finger protein 432collagen type VI alpha 1 chain
Synonyms-BTHLM1|OPLL|UCHMD1
Cytomap

19q13.41

21q22.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 432collagen alpha-1(VI) chainalpha 1 (VI) chain (61 AA)collagen VI, alpha-1 polypeptidecollagen, type VI, alpha 1epididymis secretory sperm binding protein
Modification date2020031320200328
UniProtAcc.

P12109

Ensembl transtripts involved in fusion geneENST00000221315, ENST00000594154, 
ENST00000597273, ENST00000598446, 
ENST00000498614, ENST00000361866, 
Fusion gene scores* DoF score4 X 4 X 2=3212 X 13 X 6=936
# samples 415
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(15/936*10)=-2.64154602908752
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF432 [Title/Abstract] AND COL6A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF432(52550107)-COL6A1(47404183), # samples:1
Anticipated loss of major functional domain due to fusion event.ZNF432-COL6A1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ZNF432-COL6A1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ZNF432 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across COL6A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-19-A6J5-01AZNF432chr19

52550107

-COL6A1chr21

47404183

+


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Fusion Gene ORF analysis for ZNF432-COL6A1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000221315ENST00000498614ZNF432chr19

52550107

-COL6A1chr21

47404183

+
5CDS-intronENST00000594154ENST00000498614ZNF432chr19

52550107

-COL6A1chr21

47404183

+
5CDS-intronENST00000597273ENST00000498614ZNF432chr19

52550107

-COL6A1chr21

47404183

+
Frame-shiftENST00000221315ENST00000361866ZNF432chr19

52550107

-COL6A1chr21

47404183

+
Frame-shiftENST00000597273ENST00000361866ZNF432chr19

52550107

-COL6A1chr21

47404183

+
In-frameENST00000594154ENST00000361866ZNF432chr19

52550107

-COL6A1chr21

47404183

+
intron-3CDSENST00000598446ENST00000361866ZNF432chr19

52550107

-COL6A1chr21

47404183

+
intron-intronENST00000598446ENST00000498614ZNF432chr19

52550107

-COL6A1chr21

47404183

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000594154ZNF432chr1952550107-ENST00000361866COL6A1chr2147404183+41252282203087955

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000594154ENST00000361866ZNF432chr1952550107-COL6A1chr2147404183+0.0018259450.9981741

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Fusion Genomic Features for ZNF432-COL6A1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ZNF432chr1952550106-COL6A1chr2147404182+0.0001084510.9998915
ZNF432chr1952550106-COL6A1chr2147404182+0.0001084510.9998915

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ZNF432-COL6A1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:52550107/chr21:47404183)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.COL6A1

P12109

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Collagen VI acts as a cell-binding protein.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCOL6A1chr19:52550107chr21:47404183ENST00000361866135615_805751029.0DomainVWFA 2
TgeneCOL6A1chr19:52550107chr21:47404183ENST00000361866135829_1021751029.0DomainVWFA 3
TgeneCOL6A1chr19:52550107chr21:47404183ENST00000361866135262_264751029.0MotifNote=Cell attachment site
TgeneCOL6A1chr19:52550107chr21:47404183ENST00000361866135442_444751029.0MotifNote=Cell attachment site
TgeneCOL6A1chr19:52550107chr21:47404183ENST00000361866135478_480751029.0MotifNote=Cell attachment site
TgeneCOL6A1chr19:52550107chr21:47404183ENST00000361866135257_592751029.0RegionNote=Triple-helical region
TgeneCOL6A1chr19:52550107chr21:47404183ENST00000361866135593_1028751029.0RegionNote=C-terminal globular domain

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF432chr19:52550107chr21:47404183ENST00000221315-258_795653.0DomainKRAB
HgeneZNF432chr19:52550107chr21:47404183ENST00000594154-258_795653.0DomainKRAB
HgeneZNF432chr19:52550107chr21:47404183ENST00000221315-25205_2275653.0Zinc fingerC2H2-type 1
HgeneZNF432chr19:52550107chr21:47404183ENST00000221315-25233_2555653.0Zinc fingerC2H2-type 2
HgeneZNF432chr19:52550107chr21:47404183ENST00000221315-25261_2835653.0Zinc fingerC2H2-type 3
HgeneZNF432chr19:52550107chr21:47404183ENST00000221315-25289_3115653.0Zinc fingerC2H2-type 4
HgeneZNF432chr19:52550107chr21:47404183ENST00000221315-25317_3395653.0Zinc fingerC2H2-type 5
HgeneZNF432chr19:52550107chr21:47404183ENST00000221315-25345_3675653.0Zinc fingerC2H2-type 6
HgeneZNF432chr19:52550107chr21:47404183ENST00000221315-25373_3955653.0Zinc fingerC2H2-type 7
HgeneZNF432chr19:52550107chr21:47404183ENST00000221315-25401_4235653.0Zinc fingerC2H2-type 8
HgeneZNF432chr19:52550107chr21:47404183ENST00000221315-25429_4515653.0Zinc fingerC2H2-type 9
HgeneZNF432chr19:52550107chr21:47404183ENST00000221315-25457_4795653.0Zinc fingerC2H2-type 10
HgeneZNF432chr19:52550107chr21:47404183ENST00000221315-25485_5075653.0Zinc fingerC2H2-type 11
HgeneZNF432chr19:52550107chr21:47404183ENST00000221315-25513_5355653.0Zinc fingerC2H2-type 12
HgeneZNF432chr19:52550107chr21:47404183ENST00000221315-25541_5635653.0Zinc fingerC2H2-type 13
HgeneZNF432chr19:52550107chr21:47404183ENST00000221315-25567_5915653.0Zinc fingerC2H2-type 14
HgeneZNF432chr19:52550107chr21:47404183ENST00000221315-25597_6195653.0Zinc fingerC2H2-type 15
HgeneZNF432chr19:52550107chr21:47404183ENST00000221315-25625_6475653.0Zinc fingerC2H2-type 16
HgeneZNF432chr19:52550107chr21:47404183ENST00000594154-25205_2275653.0Zinc fingerC2H2-type 1
HgeneZNF432chr19:52550107chr21:47404183ENST00000594154-25233_2555653.0Zinc fingerC2H2-type 2
HgeneZNF432chr19:52550107chr21:47404183ENST00000594154-25261_2835653.0Zinc fingerC2H2-type 3
HgeneZNF432chr19:52550107chr21:47404183ENST00000594154-25289_3115653.0Zinc fingerC2H2-type 4
HgeneZNF432chr19:52550107chr21:47404183ENST00000594154-25317_3395653.0Zinc fingerC2H2-type 5
HgeneZNF432chr19:52550107chr21:47404183ENST00000594154-25345_3675653.0Zinc fingerC2H2-type 6
HgeneZNF432chr19:52550107chr21:47404183ENST00000594154-25373_3955653.0Zinc fingerC2H2-type 7
HgeneZNF432chr19:52550107chr21:47404183ENST00000594154-25401_4235653.0Zinc fingerC2H2-type 8
HgeneZNF432chr19:52550107chr21:47404183ENST00000594154-25429_4515653.0Zinc fingerC2H2-type 9
HgeneZNF432chr19:52550107chr21:47404183ENST00000594154-25457_4795653.0Zinc fingerC2H2-type 10
HgeneZNF432chr19:52550107chr21:47404183ENST00000594154-25485_5075653.0Zinc fingerC2H2-type 11
HgeneZNF432chr19:52550107chr21:47404183ENST00000594154-25513_5355653.0Zinc fingerC2H2-type 12
HgeneZNF432chr19:52550107chr21:47404183ENST00000594154-25541_5635653.0Zinc fingerC2H2-type 13
HgeneZNF432chr19:52550107chr21:47404183ENST00000594154-25567_5915653.0Zinc fingerC2H2-type 14
HgeneZNF432chr19:52550107chr21:47404183ENST00000594154-25597_6195653.0Zinc fingerC2H2-type 15
HgeneZNF432chr19:52550107chr21:47404183ENST00000594154-25625_6475653.0Zinc fingerC2H2-type 16
TgeneCOL6A1chr19:52550107chr21:47404183ENST0000036186613537_235751029.0DomainVWFA 1
TgeneCOL6A1chr19:52550107chr21:47404183ENST0000036186613520_256751029.0RegionNote=N-terminal globular domain


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Fusion Gene Sequence for ZNF432-COL6A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>102092_102092_1_ZNF432-COL6A1_ZNF432_chr19_52550107_ENST00000594154_COL6A1_chr21_47404183_ENST00000361866_length(transcript)=4125nt_BP=228nt
GGGAGCTGGTAGGAGTCCCTGTCCACAGGTCCTGGCTACCCTGGGAAGAGACAAGAAGTAAATGAAGAAAGAGGAAGATTCCAGGACCTA
GATATGATTTCTGTGGACACCCTTCACTGGTGACTGAAGTTTCTAAATAGAAATTTAAGGCAGATCCAGAGGAGACAAAGACAGAGTATC
CCAGGTGCTGGCCATTTCCCACAACAGAAGAAAATGATCAATGCCCAGGTACTACCGCTGTGACCGAAACCTGGTGTGGAACGCAGGCGC
GCTGCACTACAGTGACGAGGTGGAGATCATCCAAGGCCTCACGCGCATGCCTGGCGGCCGCGACGCACTCAAAAGCAGCGTGGACGCGGT
CAAGTACTTTGGGAAGGGCACCTACACCGACTGCGCTATCAAGAAGGGGCTGGAGCAGCTCCTCGTGGGGGGCTCCCACCTGAAGGAGAA
TAAGTACCTGATTGTGGTGACCGACGGGCACCCCCTGGAGGGCTACAAGGAACCCTGTGGGGGGCTGGAGGATGCTGTGAACGAGGCCAA
GCACCTGGGCGTCAAAGTCTTCTCGGTGGCCATCACACCCGACCACCTGGAGCCGCGTCTGAGCATCATCGCCACGGACCACACGTACCG
GCGCAACTTCACGGCGGCTGACTGGGGCCAGAGCCGCGACGCAGAGGAGGCCATCAGCCAGACCATCGACACCATCGTGGACATGATCAA
AAATAACGTGGAGCAAGTGTGCTGCTCCTTCGAATGCCAGCCTGCAAGAGGACCTCCGGGGCTCCGGGGCGACCCCGGCTTTGAGGGAGA
ACGAGGCAAGCCGGGGCTCCCAGGAGAGAAGGGAGAAGCCGGAGATCCTGGAAGACCCGGGGACCTCGGACCTGTTGGGTACCAGGGAAT
GAAGGGAGAAAAAGGGAGCCGTGGGGAGAAGGGCTCCAGGGGACCCAAGGGCTACAAGGGAGAGAAGGGCAAGCGTGGCATCGACGGGGT
GGACGGCGTGAAGGGGGAGATGGGGTACCCAGGCCTGCCAGGCTGCAAGGGCTCGCCCGGGTTTGACGGCATTCAAGGACCCCCTGGCCC
CAAGGGAGACCCCGGTGCCTTTGGACTGAAAGGAGAAAAGGGCGAGCCTGGAGCTGACGGGGAGGCGGGGAGACCAGGGAGCTCGGGACC
ATCTGGAGACGAGGGCCAGCCGGGAGAGCCTGGGCCCCCCGGAGAGAAAGGAGAGGCGGGCGACGAGGGGAACCCAGGACCTGACGGTGC
CCCCGGGGAGCGGGGTGGCCCTGGAGAGAGAGGACCACGGGGGACCCCAGGCACGCGGGGACCAAGAGGAGACCCTGGTGAAGCTGGCCC
GCAGGGTGATCAGGGAAGAGAAGGCCCCGTTGGTGTCCCTGGAGACCCGGGCGAGGCTGGCCCTATCGGACCTAAAGGCTACCGAGGCGA
TGAGGGTCCCCCAGGGTCCGAGGGTGCCAGAGGAGCCCCAGGACCTGCCGGACCCCCTGGAGACCCGGGGCTGATGGGTGAAAGGGGAGA
AGACGGCCCCGCTGGAAATGGCACCGAGGGCTTCCCCGGCTTCCCCGGGTATCCGGGCAACAGGGGCGCTCCCGGGATAAACGGCACGAA
GGGCTACCCCGGCCTCAAGGGGGACGAGGGAGAAGCCGGGGACCCCGGAGACGATAACAACGACATTGCACCCCGAGGAGTCAAAGGAGC
AAAGGGGTACCGGGGTCCCGAGGGCCCCCAGGGACCCCCAGGACACCAAGGACCGCCTGGGCCGGACGAATGCGAGATTTTGGACATCAT
CATGAAAATGTGCTCTTGCTGTGAATGCAAGTGCGGCCCCATCGACCTCCTGTTCGTGCTGGACAGCTCAGAGAGCATTGGCCTGCAGAA
CTTCGAGATTGCCAAGGACTTCGTCGTCAAGGTCATCGACCGGCTGAGCCGGGACGAGCTGGTCAAGTTCGAGCCAGGGCAGTCGTACGC
GGGTGTGGTGCAGTACAGCCACAGCCAGATGCAGGAGCACGTGAGCCTGCGCAGCCCCAGCATCCGGAACGTGCAGGAGCTCAAGGAAGC
CATCAAGAGCCTGCAGTGGATGGCGGGCGGCACCTTCACGGGGGAGGCCCTGCAGTACACGCGGGACCAGCTGCTGCCGCCCAGCCCGAA
CAACCGCATCGCCCTGGTCATCACTGACGGGCGCTCAGACACTCAGAGGGACACCACACCGCTCAACGTGCTCTGCAGCCCCGGCATCCA
GGTGGTCTCCGTGGGCATCAAAGACGTGTTTGACTTCATCCCAGGCTCAGACCAGCTCAATGTCATTTCTTGCCAAGGCCTGGCACCATC
CCAGGGCCGGCCCGGCCTCTCGCTGGTCAAGGAGAACTATGCAGAGCTGCTGGAGGATGCCTTCCTGAAGAATGTCACCGCCCAGATCTG
CATAGACAAGAAGTGTCCAGATTACACCTGCCCCATCACGTTCTCCTCCCCGGCTGACATCACCATCCTGCTGGACGGCTCCGCCAGCGT
GGGCAGCCACAACTTTGACACCACCAAGCGCTTCGCCAAGCGCCTGGCCGAGCGCTTCCTCACAGCGGGCAGGACGGACCCCGCCCACGA
CGTGCGGGTGGCGGTGGTGCAGTACAGCGGCACGGGCCAGCAGCGCCCAGAGCGGGCGTCGCTGCAGTTCCTGCAGAACTACACGGCCCT
GGCCAGTGCCGTCGATGCCATGGACTTTATCAACGACGCCACCGACGTCAACGATGCCCTGGGCTATGTGACCCGCTTCTACCGCGAGGC
CTCGTCCGGCGCTGCCAAGAAGAGGCTGCTGCTCTTCTCAGATGGCAACTCGCAGGGCGCCACGCCCGCTGCCATCGAGAAGGCCGTGCA
GGAAGCCCAGCGGGCAGGCATCGAGATCTTCGTGGTGGTCGTGGGCCGCCAGGTGAATGAGCCCCACATCCGCGTCCTGGTCACCGGCAA
GACGGCCGAGTACGACGTGGCCTACGGCGAGAGCCACCTGTTCCGTGTCCCCAGCTACCAGGCCCTGCTCCGCGGTGTCTTCCACCAGAC
AGTCTCCAGGAAGGTGGCGCTGGGCTAGCCCACCCTGCACGCCGGCACCAAACCCTGTCCTCCCACCCCTCCCCACTCATCACTAAACAG
AGTAAAATGTGATGCGAATTTTCCCGACCAACCTGATTCGCTAGATTTTTTTTAAGGAAAAGCTTGGAAAGCCAGGACACAACGCTGCTG
CCTGCTTTGTGCAGGGTCCTCCGGGGCTCAGCCCTGAGTTGGCATCACCTGCGCAGGGCCCTCTGGGGCTCAGCCCTGAGCTAGTGTCAC
CTGCACAGGGCCCTCTGAGGCTCAGCCCTGAGCTGGCGTCACCTGTGCAGGGCCCTCTGGGGCTCAGCCCTGAGCTGGCCTCACCTGGGT
TCCCCACCCCGGGCTCTCCTGCCCTGCCCTCCTGCCCGCCCTCCCTCCTGCCTGCGCAGCTCCTTCCCTAGGCACCTCTGTGCTGCATCC
CACCAGCCTGAGCAAGACGCCCTCTCGGGGCCTGTGCCGCACTAGCCTCCCTCTCCTCTGTCCCCATAGCTGGTTTTTCCCACCAATCCT
CACCTAACAGTTACTTTACAATTAAACTCAAAGCAAGCTCTTCTCCTCAGCTTGGGGCAGCCATTGGCCTCTGTCTCGTTTTGGGAAACC
AAGGTCAGGAGGCCGTTGCAGACATAAATCTCGGCGACTCGGCCCCGTCTCCTGAGGGTCCTGCTGGTGACCGGCCTGGACCTTGGCCCT
ACAGCCCTGGAGGCCGCTGCTGACCAGCACTGACCCCGACCTCAGAGAGTACTCGCAGGGGCGCTGGCTGCACTCAAGACCCTCGAGATT
AACGGTGCTAACCCCGTCTGCTCCTCCCTCCCGCAGAGACTGGGGCCTGGACTGGACATGAGAGCCCCTTGGTGCCACAGAGGGCTGTGT
CTTACTAGAAACAACGCAAACCTCTCCTTCCTCAGAATAGTGATGTGTTCGACGTTTTATCAAAGGCCCCCTTTCTATGTTCATGTTAGT

>102092_102092_1_ZNF432-COL6A1_ZNF432_chr19_52550107_ENST00000594154_COL6A1_chr21_47404183_ENST00000361866_length(amino acids)=955AA_BP=180
MPRYYRCDRNLVWNAGALHYSDEVEIIQGLTRMPGGRDALKSSVDAVKYFGKGTYTDCAIKKGLEQLLVGGSHLKENKYLIVVTDGHPLE
GYKEPCGGLEDAVNEAKHLGVKVFSVAITPDHLEPRLSIIATDHTYRRNFTAADWGQSRDAEEAISQTIDTIVDMIKNNVEQVCCSFECQ
PARGPPGLRGDPGFEGERGKPGLPGEKGEAGDPGRPGDLGPVGYQGMKGEKGSRGEKGSRGPKGYKGEKGKRGIDGVDGVKGEMGYPGLP
GCKGSPGFDGIQGPPGPKGDPGAFGLKGEKGEPGADGEAGRPGSSGPSGDEGQPGEPGPPGEKGEAGDEGNPGPDGAPGERGGPGERGPR
GTPGTRGPRGDPGEAGPQGDQGREGPVGVPGDPGEAGPIGPKGYRGDEGPPGSEGARGAPGPAGPPGDPGLMGERGEDGPAGNGTEGFPG
FPGYPGNRGAPGINGTKGYPGLKGDEGEAGDPGDDNNDIAPRGVKGAKGYRGPEGPQGPPGHQGPPGPDECEILDIIMKMCSCCECKCGP
IDLLFVLDSSESIGLQNFEIAKDFVVKVIDRLSRDELVKFEPGQSYAGVVQYSHSQMQEHVSLRSPSIRNVQELKEAIKSLQWMAGGTFT
GEALQYTRDQLLPPSPNNRIALVITDGRSDTQRDTTPLNVLCSPGIQVVSVGIKDVFDFIPGSDQLNVISCQGLAPSQGRPGLSLVKENY
AELLEDAFLKNVTAQICIDKKCPDYTCPITFSSPADITILLDGSASVGSHNFDTTKRFAKRLAERFLTAGRTDPAHDVRVAVVQYSGTGQ
QRPERASLQFLQNYTALASAVDAMDFINDATDVNDALGYVTRFYREASSGAAKKRLLLFSDGNSQGATPAAIEKAVQEAQRAGIEIFVVV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZNF432-COL6A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF432-COL6A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF432-COL6A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource