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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF440-ECSIT (FusionGDB2 ID:102129)

Fusion Gene Summary for ZNF440-ECSIT

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF440-ECSIT
Fusion gene ID: 102129
HgeneTgene
Gene symbol

ZNF440

ECSIT

Gene ID

126070

51295

Gene namezinc finger protein 440ECSIT signaling integrator
Synonyms-SITPEC
Cytomap

19p13.2

19p13.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 440evolutionarily conserved signaling intermediate in Toll pathway, mitochondrialECSIT homologECSIT signalling integratorlikely ortholog of mouse signaling intermediate in Toll pathway evolutionarily conserved
Modification date2020031320200313
UniProtAcc.

Q9BQ95

Ensembl transtripts involved in fusion geneENST00000304060, ENST00000252440, 
ENST00000270517, ENST00000417981, 
ENST00000588998, ENST00000591104, 
ENST00000591352, ENST00000592312, 
Fusion gene scores* DoF score3 X 2 X 4=246 X 5 X 5=150
# samples 48
** MAII scorelog2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(8/150*10)=-0.906890595608519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF440 [Title/Abstract] AND ECSIT [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF440(11925265)-ECSIT(11618863), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneECSIT

GO:0051341

regulation of oxidoreductase activity

17344420

TgeneECSIT

GO:0061635

regulation of protein complex stability

17344420


check buttonFusion gene breakpoints across ZNF440 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ECSIT (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UVMTCGA-VD-AA8M-01AZNF440chr19

11925265

+ECSITchr19

11618863

-
ChimerDB4UVMTCGA-VD-AA8MZNF440chr19

11925265

+ECSITchr19

11618863

-
ChiTaRS5.0N/ABG222450ZNF440chr19

11945695

-ECSITchr19

11633709

-


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Fusion Gene ORF analysis for ZNF440-ECSIT

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000304060ENST00000252440ZNF440chr19

11945695

-ECSITchr19

11633709

-
3UTR-intronENST00000304060ENST00000270517ZNF440chr19

11945695

-ECSITchr19

11633709

-
3UTR-intronENST00000304060ENST00000417981ZNF440chr19

11945695

-ECSITchr19

11633709

-
3UTR-intronENST00000304060ENST00000588998ZNF440chr19

11945695

-ECSITchr19

11633709

-
3UTR-intronENST00000304060ENST00000591104ZNF440chr19

11945695

-ECSITchr19

11633709

-
3UTR-intronENST00000304060ENST00000591352ZNF440chr19

11945695

-ECSITchr19

11633709

-
3UTR-intronENST00000304060ENST00000592312ZNF440chr19

11945695

-ECSITchr19

11633709

-
5CDS-5UTRENST00000304060ENST00000591352ZNF440chr19

11925265

+ECSITchr19

11618863

-
In-frameENST00000304060ENST00000252440ZNF440chr19

11925265

+ECSITchr19

11618863

-
In-frameENST00000304060ENST00000270517ZNF440chr19

11925265

+ECSITchr19

11618863

-
In-frameENST00000304060ENST00000417981ZNF440chr19

11925265

+ECSITchr19

11618863

-
In-frameENST00000304060ENST00000588998ZNF440chr19

11925265

+ECSITchr19

11618863

-
In-frameENST00000304060ENST00000591104ZNF440chr19

11925265

+ECSITchr19

11618863

-
In-frameENST00000304060ENST00000592312ZNF440chr19

11925265

+ECSITchr19

11618863

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000304060ZNF440chr1911925265+ENST00000270517ECSITchr1911618863-993167811185208
ENST00000304060ZNF440chr1911925265+ENST00000588998ECSITchr1911618863-831167662108184
ENST00000304060ZNF440chr1911925265+ENST00000252440ECSITchr1911618863-831167662108184
ENST00000304060ZNF440chr1911925265+ENST00000417981ECSITchr1911618863-907167164724186
ENST00000304060ZNF440chr1911925265+ENST00000591104ECSITchr1911618863-6041675971199
ENST00000304060ZNF440chr1911925265+ENST00000592312ECSITchr1911618863-7481677261242

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000304060ENST00000270517ZNF440chr1911925265+ECSITchr1911618863-0.0046243090.99537563
ENST00000304060ENST00000588998ZNF440chr1911925265+ECSITchr1911618863-0.180962850.81903714
ENST00000304060ENST00000252440ZNF440chr1911925265+ECSITchr1911618863-0.180962850.81903714
ENST00000304060ENST00000417981ZNF440chr1911925265+ECSITchr1911618863-0.0037485860.9962514
ENST00000304060ENST00000591104ZNF440chr1911925265+ECSITchr1911618863-0.018058270.9819417
ENST00000304060ENST00000592312ZNF440chr1911925265+ECSITchr1911618863-0.423545180.5764549

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Fusion Genomic Features for ZNF440-ECSIT


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF440-ECSIT


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:11925265/chr19:11618863)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ECSIT

Q9BQ95

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity). {ECO:0000250}.; FUNCTION: Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF440chr19:11925265chr19:11618863ENST00000304060+144_861596.0DomainKRAB
HgeneZNF440chr19:11925265chr19:11618863ENST00000304060+14144_1661596.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF440chr19:11925265chr19:11618863ENST00000304060+14172_1941596.0Zinc fingerC2H2-type 2
HgeneZNF440chr19:11925265chr19:11618863ENST00000304060+14200_2221596.0Zinc fingerC2H2-type 3
HgeneZNF440chr19:11925265chr19:11618863ENST00000304060+14228_2501596.0Zinc fingerC2H2-type 4
HgeneZNF440chr19:11925265chr19:11618863ENST00000304060+14256_2781596.0Zinc fingerC2H2-type 5%3B degenerate
HgeneZNF440chr19:11925265chr19:11618863ENST00000304060+14284_3061596.0Zinc fingerC2H2-type 6
HgeneZNF440chr19:11925265chr19:11618863ENST00000304060+14312_3341596.0Zinc fingerC2H2-type 7
HgeneZNF440chr19:11925265chr19:11618863ENST00000304060+14340_3621596.0Zinc fingerC2H2-type 8
HgeneZNF440chr19:11925265chr19:11618863ENST00000304060+14368_3901596.0Zinc fingerC2H2-type 9
HgeneZNF440chr19:11925265chr19:11618863ENST00000304060+14396_4181596.0Zinc fingerC2H2-type 10
HgeneZNF440chr19:11925265chr19:11618863ENST00000304060+14424_4481596.0Zinc fingerC2H2-type 11
HgeneZNF440chr19:11925265chr19:11618863ENST00000304060+14458_4801596.0Zinc fingerC2H2-type 12


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Fusion Gene Sequence for ZNF440-ECSIT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>102129_102129_1_ZNF440-ECSIT_ZNF440_chr19_11925265_ENST00000304060_ECSIT_chr19_11618863_ENST00000252440_length(transcript)=831nt_BP=167nt
ATTCCTTTAGTGCTGCGCCGACAGCGGTCAGGATCTCGGCTTTCTTGCTTCGAGAGGGACTAGGTGCCTCCACCAGAGCTTCTGTCGCTC
TGTAACCTGCACTGTGACCTACACTAGTCGCGGGAGCCACGCAGAGGACGCCGGAACACCCTGGAAGCCGAGAAATGGTTCCTTTGCCCA
AAGACTCAACAGGTGCAGCAGATCCCCCCCAGCCCCACATCGTAGGAAGTGGAAGAGACGCCGGAGGAGTGGAACCTCTACTACCCGATG
CAGCTGGACCTGGAGTATGTGAGGAGTGGCTGGGACAACTACGAGTTTGACATCAATGAAGTGGAGGAAGGCCCTGTCTTCGCCATGTGC
ATGGCGGGTGCTCATGACCAGGCGACGATGGCTAAGTGGATCCAGGGCCTGCAGGAGACCAACCCAACCCTGGCCCAGATCCCCGTGGTC
TTCCGCCTCGCCGGGTCCACCCGGGAGCTCCAGACATCCTCTGCAGGGCTGGAGGAGCCGCCCCTGCCCGAGGACCACCAGGAAGAAGAC
GACAACCTGCAGCGACAGCAGCAGGGCCAGAGCTAGTCTGAGCCGGCGCGAGGGCACGGGCTGTGGCCCGAGGAGGCGGTGGACTGAAGG
CATGAGATGCCCTTTGAGTGTACAGCAAATCAATGTTTTCCTGCTTGGGGCTCTCTTCCCTCATCTCTAGCAGTATGGCATCCCCTCCCC
AGGATCTCGGGCTGCCAGCGATGGGCAGGCGAGACCCCTCCAGAATCTGCAGGCGCCTCTGGTTCTCCGAATTCAAATAAAAAGGGGCGG

>102129_102129_1_ZNF440-ECSIT_ZNF440_chr19_11925265_ENST00000304060_ECSIT_chr19_11618863_ENST00000252440_length(amino acids)=184AA_BP=1
MICCTLKGHLMPSVHRLLGPQPVPSRRLRLALALLLSLQVVVFFLVVLGQGRLLQPCRGCLELPGGPGEAEDHGDLGQGWVGLLQALDPL
SHRRLVMSTRHAHGEDRAFLHFIDVKLVVVPATPHILQVQLHRVVEVPLLRRLFHFLRCGAGGDLLHLLSLWAKEPFLGFQGVPASSAWL

--------------------------------------------------------------
>102129_102129_2_ZNF440-ECSIT_ZNF440_chr19_11925265_ENST00000304060_ECSIT_chr19_11618863_ENST00000270517_length(transcript)=993nt_BP=167nt
ATTCCTTTAGTGCTGCGCCGACAGCGGTCAGGATCTCGGCTTTCTTGCTTCGAGAGGGACTAGGTGCCTCCACCAGAGCTTCTGTCGCTC
TGTAACCTGCACTGTGACCTACACTAGTCGCGGGAGCCACGCAGAGGACGCCGGAACACCCTGGAAGCCGAGAAATGGTTCCTTTGCCCA
AAGACTCAACAGGTGCAGCAGATCCCCCCCAGCCCCACATCGTAGGAATCCAGAGTCCCGATCAGCAGGCCGCCCTGGCCCGCCACAATC
CAGCCCGGCCTGTCTTTGTTGAGGGCCCCTTCTCCCTGTGGCTCCGCAACAAGTGTGTGTATTACCACATCCTCAGAGCTGACTTGCTGC
CCCCGGAGGAGAGGGAAGTGGAAGAGACGCCGGAGGAGTGGAACCTCTACTACCCGATGCAGCTGGACCTGGAGTATGTGAGGAGTGGCT
GGGACAACTACGAGTTTGACATCAATGAAGTGGAGGAAGGCCCTGTCTTCGCCATGTGCATGGCGGGTGCTCATGACCAGGCGACGATGG
CTAAGTGGATCCAGGGCCTGCAGGAGACCAACCCAACCCTGGCCCAGATCCCCGTGGTCTTCCGCCTCGCCGGGTCCACCCGGGAGCTCC
AGACATCCTCTGCAGGGCTGGAGGAGCCGCCCCTGCCCGAGGACCACCAGGAAGAAGACGACAACCTGCAGCGACAGCAGCAGGGCCAGA
GCTAGTCTGAGCCGGCGCGAGGGCACGGGCTGTGGCCCGAGGAGGCGGTGGACTGAAGGCATGAGATGCCCTTTGAGTGTACAGCAAATC
AATGTTTTCCTGCTTGGGGCTCTCTTCCCTCATCTCTAGCAGTATGGCATCCCCTCCCCAGGATCTCGGGCTGCCAGCGATGGGCAGGCG
AGACCCCTCCAGAATCTGCAGGCGCCTCTGGTTCTCCGAATTCAAATAAAAAGGGGCGGGAGCGCTGTTGGTTGTGCGCATGCGCAGTTT

>102129_102129_2_ZNF440-ECSIT_ZNF440_chr19_11925265_ENST00000304060_ECSIT_chr19_11618863_ENST00000270517_length(amino acids)=208AA_BP=
MICCTLKGHLMPSVHRLLGPQPVPSRRLRLALALLLSLQVVVFFLVVLGQGRLLQPCRGCLELPGGPGEAEDHGDLGQGWVGLLQALDPL
SHRRLVMSTRHAHGEDRAFLHFIDVKLVVVPATPHILQVQLHRVVEVPLLRRLFHFPLLRGQQVSSEDVVIHTLVAEPQGEGALNKDRPG

--------------------------------------------------------------
>102129_102129_3_ZNF440-ECSIT_ZNF440_chr19_11925265_ENST00000304060_ECSIT_chr19_11618863_ENST00000417981_length(transcript)=907nt_BP=167nt
ATTCCTTTAGTGCTGCGCCGACAGCGGTCAGGATCTCGGCTTTCTTGCTTCGAGAGGGACTAGGTGCCTCCACCAGAGCTTCTGTCGCTC
TGTAACCTGCACTGTGACCTACACTAGTCGCGGGAGCCACGCAGAGGACGCCGGAACACCCTGGAAGCCGAGAAATGGTTCCTTTGCCCA
AAGACTCAACAGGTGCAGCAGATCCCCCCCAGCCCCACATCGTAGGAATCCAGAGTCCCGATCAGCAGGCCGCCCTGGCCCGCCACAATC
CAGCCCGGCCTGTCTTTGTTGAGGGCCCCTTCTCCCTGTGGCTCCGCAACAAGTGTGTGTATTACCACATCCTCAGAGCTGACTTGCTGC
CCCCGGAGGAGAGGGAAGTGGAAGAGACGCCGGAGGAGTGGAACCTCTACTACCCGATGCAGCTGGACCTGGAGTATGTGAGGAGTGGCT
GGGACAACTACGAGTTTGACATCAATGAAGTGGAGGAAGGCCCTGTCTTCGCCATGTGCATGGCGGGTGCTCATGACCAGGCGACGATGG
CTAAGTGGATCCAGGGCCTGCAGGAGACCAACCCAACCCTGGCCCAGATCCCCGTGGTCTTCCGCCTCGCCGGGTCCACCCGGGAGCTCC
AGACATCCTCTGCAGGGCTGGAGGAGCCGCCCCTGCCCGAGGACCACCAGGAAGAAGACGACAACCTGCAGCGACAGCAGCAGGGCCAGA
GCTAGTCTGAGCCGGCGCGAGGGCACGGGCTGTGGCCCGAGGAGGCGGTGGACTGAAGGCATGAGATGCCCTTTGAGTGTACAGCAAATC
AATGTTTTCCTGCTTGGGGCTCTCTTCCCTCATCTCTAGCAGTATGGCATCCCCTCCCCAGGATCTCGGGCTGCCAGCGATGGGCAGGCG

>102129_102129_3_ZNF440-ECSIT_ZNF440_chr19_11925265_ENST00000304060_ECSIT_chr19_11618863_ENST00000417981_length(amino acids)=186AA_BP=1
MVPLPKDSTGAADPPQPHIVGIQSPDQQAALARHNPARPVFVEGPFSLWLRNKCVYYHILRADLLPPEEREVEETPEEWNLYYPMQLDLE
YVRSGWDNYEFDINEVEEGPVFAMCMAGAHDQATMAKWIQGLQETNPTLAQIPVVFRLAGSTRELQTSSAGLEEPPLPEDHQEEDDNLQR

--------------------------------------------------------------
>102129_102129_4_ZNF440-ECSIT_ZNF440_chr19_11925265_ENST00000304060_ECSIT_chr19_11618863_ENST00000588998_length(transcript)=831nt_BP=167nt
ATTCCTTTAGTGCTGCGCCGACAGCGGTCAGGATCTCGGCTTTCTTGCTTCGAGAGGGACTAGGTGCCTCCACCAGAGCTTCTGTCGCTC
TGTAACCTGCACTGTGACCTACACTAGTCGCGGGAGCCACGCAGAGGACGCCGGAACACCCTGGAAGCCGAGAAATGGTTCCTTTGCCCA
AAGACTCAACAGGTGCAGCAGATCCCCCCCAGCCCCACATCGTAGGAAGTGGAAGAGACGCCGGAGGAGTGGAACCTCTACTACCCGATG
CAGCTGGACCTGGAGTATGTGAGGAGTGGCTGGGACAACTACGAGTTTGACATCAATGAAGTGGAGGAAGGCCCTGTCTTCGCCATGTGC
ATGGCGGGTGCTCATGACCAGGCGACGATGGCTAAGTGGATCCAGGGCCTGCAGGAGACCAACCCAACCCTGGCCCAGATCCCCGTGGTC
TTCCGCCTCGCCGGGTCCACCCGGGAGCTCCAGACATCCTCTGCAGGGCTGGAGGAGCCGCCCCTGCCCGAGGACCACCAGGAAGAAGAC
GACAACCTGCAGCGACAGCAGCAGGGCCAGAGCTAGTCTGAGCCGGCGCGAGGGCACGGGCTGTGGCCCGAGGAGGCGGTGGACTGAAGG
CATGAGATGCCCTTTGAGTGTACAGCAAATCAATGTTTTCCTGCTTGGGGCTCTCTTCCCTCATCTCTAGCAGTATGGCATCCCCTCCCC
AGGATCTCGGGCTGCCAGCGATGGGCAGGCGAGACCCCTCCAGAATCTGCAGGCGCCTCTGGTTCTCCGAATTCAAATAAAAAGGGGCGG

>102129_102129_4_ZNF440-ECSIT_ZNF440_chr19_11925265_ENST00000304060_ECSIT_chr19_11618863_ENST00000588998_length(amino acids)=184AA_BP=1
MICCTLKGHLMPSVHRLLGPQPVPSRRLRLALALLLSLQVVVFFLVVLGQGRLLQPCRGCLELPGGPGEAEDHGDLGQGWVGLLQALDPL
SHRRLVMSTRHAHGEDRAFLHFIDVKLVVVPATPHILQVQLHRVVEVPLLRRLFHFLRCGAGGDLLHLLSLWAKEPFLGFQGVPASSAWL

--------------------------------------------------------------
>102129_102129_5_ZNF440-ECSIT_ZNF440_chr19_11925265_ENST00000304060_ECSIT_chr19_11618863_ENST00000591104_length(transcript)=604nt_BP=167nt
ATTCCTTTAGTGCTGCGCCGACAGCGGTCAGGATCTCGGCTTTCTTGCTTCGAGAGGGACTAGGTGCCTCCACCAGAGCTTCTGTCGCTC
TGTAACCTGCACTGTGACCTACACTAGTCGCGGGAGCCACGCAGAGGACGCCGGAACACCCTGGAAGCCGAGAAATGGTTCCTTTGCCCA
AAGACTCAACAGGTGCAGCAGATCCCCCCCAGCCCCACATCGTAGAGCTGACTTGCTGCCCCCGGAGGAGAGGGAAGTGGAAGAGACGCC
GGAGGAGTGGAACCTCTACTACCCGATGCAGCTGGACCTGGAGTATGTGAGGAGTGGCTGGGACAACTACGAGTTTGACATCAATGAAGT
GGAGGAAGGCCCTGTCTTCGCCATGTGCATGGCGGGTGCTCATGACCAGGCGACGATGGCTAAGTGGATCCAGGGCCTGCAGGAGACCAA
CCCAACCCTGGCCCAGATCCCCGTGGTCTTCCGCCTCGCCGGGTCCACCCGGGAGCTCCAGACATCCTCTGCAGGGCTGGAGGAGCCGCC

>102129_102129_5_ZNF440-ECSIT_ZNF440_chr19_11925265_ENST00000304060_ECSIT_chr19_11618863_ENST00000591104_length(amino acids)=199AA_BP=1
MALLLSLQVVVFFLVVLGQGRLLQPCRGCLELPGGPGEAEDHGDLGQGWVGLLQALDPLSHRRLVMSTRHAHGEDRAFLHFIDVKLVVVP
ATPHILQVQLHRVVEVPLLRRLFHFPLLRGQQVSSTMWGWGGSAAPVESLGKGTISRLPGCSGVLCVAPATSVGHSAGYRATEALVEAPS

--------------------------------------------------------------
>102129_102129_6_ZNF440-ECSIT_ZNF440_chr19_11925265_ENST00000304060_ECSIT_chr19_11618863_ENST00000592312_length(transcript)=748nt_BP=167nt
ATTCCTTTAGTGCTGCGCCGACAGCGGTCAGGATCTCGGCTTTCTTGCTTCGAGAGGGACTAGGTGCCTCCACCAGAGCTTCTGTCGCTC
TGTAACCTGCACTGTGACCTACACTAGTCGCGGGAGCCACGCAGAGGACGCCGGAACACCCTGGAAGCCGAGAAATGGTTCCTTTGCCCA
AAGACTCAACAGGTGCAGCAGATCCCCCCCAGCCCCACATCGTAGGTAAGTCCGAGAGCATGGGGGCAGCCAAGTCTCTAACCTTACCCA
GGCCCTGCCAGGTTCTCGCTGGGCCTAGGCTGGGCTCCCTGGGCCTCTGGGCCGAGTCCCTTGCAGGGCACAGGGCATGTATGTCTCCAC
ACCAGGAATCCAGAGTCCCGATCAGCAGGCCGCCCTGGCCCGCCACAATCCAGCCCGGCCTGTCTTTGTTGAGGGCCCCTTCTCCCTGTG
GCTCCGCAACAAGTGTGTGTATTACCACATCCTCAGAGCTGACTTGCTGCCCCCGGAGGAGAGGGAAGTGGAAGAGACGCCGGAGGAGTG
GAACCTCTACTACCCGATGCAGCTGGACCTGGAGTATGTGAGGAGTGGCTGGGACAACTACGAGTTTGACATCAATGAAGTGGAGGAAGG
CCCTGTCTTCGCCATGTGCATGGCGGGTGCTCATGACCAGGCGACGATGGCTAAGTGGATCCAGGGCCTGCAGGAGACCAACCCAACCCT

>102129_102129_6_ZNF440-ECSIT_ZNF440_chr19_11925265_ENST00000304060_ECSIT_chr19_11618863_ENST00000592312_length(amino acids)=242AA_BP=1
MGQGWVGLLQALDPLSHRRLVMSTRHAHGEDRAFLHFIDVKLVVVPATPHILQVQLHRVVEVPLLRRLFHFPLLRGQQVSSEDVVIHTLV
AEPQGEGALNKDRPGWIVAGQGGLLIGTLDSWCGDIHALCPARDSAQRPREPSLGPARTWQGLGKVRDLAAPMLSDLPTMWGWGGSAAPV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZNF440-ECSIT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF440-ECSIT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF440-ECSIT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource