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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF443-MYO9B (FusionGDB2 ID:102134)

Fusion Gene Summary for ZNF443-MYO9B

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF443-MYO9B
Fusion gene ID: 102134
HgeneTgene
Gene symbol

ZNF443

MYO9B

Gene ID

10224

4650

Gene namezinc finger protein 443myosin IXB
SynonymsZK1CELIAC4|MYR5
Cytomap

19p13.2

19p13.11

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 443Kruppel-type zinc finger (C2H2)krueppel-type zinc finger protein ZK1unconventional myosin-IXbmyosin-IXbunconventional myosin-9b
Modification date2020031320200313
UniProtAcc.

Q13459

Ensembl transtripts involved in fusion geneENST00000301547, ENST00000593411, 
ENST00000397274, ENST00000594824, 
ENST00000595618, 
Fusion gene scores* DoF score2 X 3 X 2=1215 X 18 X 8=2160
# samples 218
** MAII scorelog2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(18/2160*10)=-3.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF443 [Title/Abstract] AND MYO9B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF443(12551726)-MYO9B(17303555), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMYO9B

GO:0030048

actin filament-based movement

9490638

TgeneMYO9B

GO:0032011

ARF protein signal transduction

15644318

TgeneMYO9B

GO:0035385

Roundabout signaling pathway

26529257


check buttonFusion gene breakpoints across ZNF443 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MYO9B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-25-1319-01AZNF443chr19

12511882

-MYO9Bchr19

17303555

+
ChimerDB4OVTCGA-25-1319-01AZNF443chr19

12551726

-MYO9Bchr19

17303555

+


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Fusion Gene ORF analysis for ZNF443-MYO9B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000301547ENST00000593411ZNF443chr19

12551726

-MYO9Bchr19

17303555

+
In-frameENST00000301547ENST00000397274ZNF443chr19

12551726

-MYO9Bchr19

17303555

+
In-frameENST00000301547ENST00000594824ZNF443chr19

12551726

-MYO9Bchr19

17303555

+
In-frameENST00000301547ENST00000595618ZNF443chr19

12551726

-MYO9Bchr19

17303555

+
intron-3CDSENST00000301547ENST00000397274ZNF443chr19

12511882

-MYO9Bchr19

17303555

+
intron-3CDSENST00000301547ENST00000594824ZNF443chr19

12511882

-MYO9Bchr19

17303555

+
intron-3CDSENST00000301547ENST00000595618ZNF443chr19

12511882

-MYO9Bchr19

17303555

+
intron-intronENST00000301547ENST00000593411ZNF443chr19

12511882

-MYO9Bchr19

17303555

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000301547ZNF443chr1912551726-ENST00000595618MYO9Bchr1917303555+486120117434581094
ENST00000301547ZNF443chr1912551726-ENST00000594824MYO9Bchr1917303555+483820117438631229
ENST00000301547ZNF443chr1912551726-ENST00000397274MYO9Bchr1917303555+486020117434581094

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000301547ENST00000595618ZNF443chr1912551726-MYO9Bchr1917303555+0.0046168680.9953831
ENST00000301547ENST00000594824ZNF443chr1912551726-MYO9Bchr1917303555+0.0082876860.99171233
ENST00000301547ENST00000397274ZNF443chr1912551726-MYO9Bchr1917303555+0.0045827650.99541724

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Fusion Genomic Features for ZNF443-MYO9B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ZNF443chr1912551725-MYO9Bchr1917303554+2.08E-081
ZNF443chr1912551725-MYO9Bchr1917303554+2.08E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ZNF443-MYO9B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:12551726/chr19:17303555)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MYO9B

Q13459

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:9490638, PubMed:26529257). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMYO9Bchr19:12551726chr19:17303555ENST0000039727418391046_10719372189.0Coiled coilOntology_term=ECO:0000255
TgeneMYO9Bchr19:12551726chr19:17303555ENST0000039727418391880_19019372189.0Coiled coilOntology_term=ECO:0000255
TgeneMYO9Bchr19:12551726chr19:17303555ENST0000039727418391959_19899372189.0Coiled coilOntology_term=ECO:0000255
TgeneMYO9Bchr19:12551726chr19:17303555ENST0000059561819401046_10719372458.6666666666665Coiled coilOntology_term=ECO:0000255
TgeneMYO9Bchr19:12551726chr19:17303555ENST0000059561819401880_19019372458.6666666666665Coiled coilOntology_term=ECO:0000255
TgeneMYO9Bchr19:12551726chr19:17303555ENST0000059561819401959_19899372458.6666666666665Coiled coilOntology_term=ECO:0000255
TgeneMYO9Bchr19:12551726chr19:17303555ENST0000039727418391001_10239372189.0DomainIQ 3
TgeneMYO9Bchr19:12551726chr19:17303555ENST0000039727418391024_10539372189.0DomainIQ 4
TgeneMYO9Bchr19:12551726chr19:17303555ENST0000039727418391703_18889372189.0DomainRho-GAP
TgeneMYO9Bchr19:12551726chr19:17303555ENST000003972741839957_9779372189.0DomainIQ 1
TgeneMYO9Bchr19:12551726chr19:17303555ENST000003972741839979_10009372189.0DomainIQ 2
TgeneMYO9Bchr19:12551726chr19:17303555ENST0000059561819401001_10239372458.6666666666665DomainIQ 3
TgeneMYO9Bchr19:12551726chr19:17303555ENST0000059561819401024_10539372458.6666666666665DomainIQ 4
TgeneMYO9Bchr19:12551726chr19:17303555ENST0000059561819401703_18889372458.6666666666665DomainRho-GAP
TgeneMYO9Bchr19:12551726chr19:17303555ENST000005956181940957_9779372458.6666666666665DomainIQ 1
TgeneMYO9Bchr19:12551726chr19:17303555ENST000005956181940979_10009372458.6666666666665DomainIQ 2
TgeneMYO9Bchr19:12551726chr19:17303555ENST0000039727418391045_21579372189.0RegionTail
TgeneMYO9Bchr19:12551726chr19:17303555ENST000003972741839940_10449372189.0RegionNeck or regulatory domain
TgeneMYO9Bchr19:12551726chr19:17303555ENST0000059561819401045_21579372458.6666666666665RegionTail
TgeneMYO9Bchr19:12551726chr19:17303555ENST000005956181940940_10449372458.6666666666665RegionNeck or regulatory domain
TgeneMYO9Bchr19:12551726chr19:17303555ENST0000039727418391632_16819372189.0Zinc fingerPhorbol-ester/DAG-type
TgeneMYO9Bchr19:12551726chr19:17303555ENST0000059561819401632_16819372458.6666666666665Zinc fingerPhorbol-ester/DAG-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF443chr19:12551726chr19:17303555ENST00000301547-144_861672.0DomainKRAB
HgeneZNF443chr19:12551726chr19:17303555ENST00000301547-14134_1591672.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF443chr19:12551726chr19:17303555ENST00000301547-14169_1911672.0Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF443chr19:12551726chr19:17303555ENST00000301547-14197_2191672.0Zinc fingerC2H2-type 3
HgeneZNF443chr19:12551726chr19:17303555ENST00000301547-14225_2471672.0Zinc fingerC2H2-type 4
HgeneZNF443chr19:12551726chr19:17303555ENST00000301547-14253_2751672.0Zinc fingerC2H2-type 5
HgeneZNF443chr19:12551726chr19:17303555ENST00000301547-14281_3031672.0Zinc fingerC2H2-type 6
HgeneZNF443chr19:12551726chr19:17303555ENST00000301547-14309_3311672.0Zinc fingerC2H2-type 7
HgeneZNF443chr19:12551726chr19:17303555ENST00000301547-14337_3591672.0Zinc fingerC2H2-type 8
HgeneZNF443chr19:12551726chr19:17303555ENST00000301547-14365_3871672.0Zinc fingerC2H2-type 9
HgeneZNF443chr19:12551726chr19:17303555ENST00000301547-14393_4151672.0Zinc fingerC2H2-type 10
HgeneZNF443chr19:12551726chr19:17303555ENST00000301547-14421_4431672.0Zinc fingerC2H2-type 11
HgeneZNF443chr19:12551726chr19:17303555ENST00000301547-14449_4711672.0Zinc fingerC2H2-type 12
HgeneZNF443chr19:12551726chr19:17303555ENST00000301547-14477_4981672.0Zinc fingerC2H2-type 13%3B degenerate
HgeneZNF443chr19:12551726chr19:17303555ENST00000301547-14504_5261672.0Zinc fingerC2H2-type 14
HgeneZNF443chr19:12551726chr19:17303555ENST00000301547-14532_5541672.0Zinc fingerC2H2-type 15
HgeneZNF443chr19:12551726chr19:17303555ENST00000301547-14560_5821672.0Zinc fingerC2H2-type 16
HgeneZNF443chr19:12551726chr19:17303555ENST00000301547-14588_6101672.0Zinc fingerC2H2-type 17
HgeneZNF443chr19:12551726chr19:17303555ENST00000301547-14616_6381672.0Zinc fingerC2H2-type 18
HgeneZNF443chr19:12551726chr19:17303555ENST00000301547-14649_6711672.0Zinc fingerC2H2-type 19
TgeneMYO9Bchr19:12551726chr19:17303555ENST000003972741839146_9539372189.0DomainMyosin motor
TgeneMYO9Bchr19:12551726chr19:17303555ENST00000397274183915_1149372189.0DomainRas-associating
TgeneMYO9Bchr19:12551726chr19:17303555ENST000005956181940146_9539372458.6666666666665DomainMyosin motor
TgeneMYO9Bchr19:12551726chr19:17303555ENST00000595618194015_1149372458.6666666666665DomainRas-associating
TgeneMYO9Bchr19:12551726chr19:17303555ENST000003972741839239_2469372189.0Nucleotide bindingATP
TgeneMYO9Bchr19:12551726chr19:17303555ENST000005956181940239_2469372458.6666666666665Nucleotide bindingATP
TgeneMYO9Bchr19:12551726chr19:17303555ENST000003972741839844_8559372189.0RegionActin-binding
TgeneMYO9Bchr19:12551726chr19:17303555ENST000005956181940844_8559372458.6666666666665RegionActin-binding


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Fusion Gene Sequence for ZNF443-MYO9B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>102134_102134_1_ZNF443-MYO9B_ZNF443_chr19_12551726_ENST00000301547_MYO9B_chr19_17303555_ENST00000397274_length(transcript)=4860nt_BP=201nt
AACTGTCAATCAGGCACTGCCCAGAGAAGTGTGTGTGGTTGAAAAAGCCCGCGGCGTCTGCTCCACCCACCTGCGCTCGGCTCTGGGTTC
TGTAGCTGAGAGACGACCTGGAAGTTCTGAGGCAGCCTTTGTCTGGCTGGAACACGCATTGGCAGCGGGAGCTGTCGGTAGGACCTGGGA
CACCGCGGAAGTCGGGAAATGGTCTTCCTGAAGGAGACGGAGCGGCAAGCCCTGCAGGAGACGCTGCACCGGGAGGTGGTGCGGAAAATC
CTGCTGCTGCAGAGCTGGTTCCGGATGGTGCTGGAGCGTCGGCACTTCCTGCAGATGAAGCGGGCCGCCGTCACCATCCAGGCCTGCTGG
CGGTCCTACCGGGTCCGGAGGGCGCTGGAGAGGACGCAGGCTGCCGTGTACCTCCAGGCCTCATGGAGGGGCTACTGGCAGCGGAAGCTC
TACCGGCACCAGAAACAGAGCATCATCCGCCTGCAGAGCCTGTGTCGGGGGCACCTGCAGCGCAAGAGCTTCAGCCAGATGATCTCGGAG
AAGCAGAAGGCAGAAGAGAAGGAGAGGGAAGCCCTGGAAGCCGCAAGAGCAGGTGCTGAGGAGGGCGGACAGGGTCAGGCGGCTGGAGGG
CAGCAGGTAGCTGAGCAGGGGCCGGAGCCAGCGGAGGATGGCGGGCACCTGGCATCGGAGCCTGAGGTGCAGCCAAGTGACAGGTCCCCC
CTAGAGCACTCCTCACCTGAGAAGGAGGCCCCAAGCCCAGAGAAGACTCTCCCACCCCAGAAAACCGTGGCGGCTGAAAGTCACGAGAAA
GTCCCCAGCAGCCGGGAGAAGCGTGAGTCGCGTCGGCAAAGAGGGCTGGAGCACGTCAAGTTCCAGAACAAACACATCCAGTCCTGCAAG
GAGGAGAGTGCCCTCAGAGAACCTTCCAGAAGGGTCACCCAGGAGCAAGGGGTGAGTCTCCTGGAAGACAAAAAGGAGAGCAGAGAAGAT
GAAACCCTTCTAGTCGTAGAGACGGAGGCTGAGAACACATCTCAAAAGCAGCCCACAGAGCAACCCCAGGCCATGGCAGTTGGCAAGGTC
TCTGAAGAAACTGAGAAGACGCTGCCCAGTGGGAGCCCCAGGCCTGGCCAGTTGGAGCGGCCGACCAGCCTGGCCCTGGACAGCAGGGTC
AGCCCACCGGCCCCTGGCAGCGCCCCCGAGACCCCCGAGGACAAGAGCAAACCATGTGGCAGCCCAAGGGTTCAGGAAAAGCCCGACAGC
CCCGGAGGCTCCACGCAGATCCAGCGGTACCTGGACGCCGAGCGGCTGGCCAGCGCCGTGGAACTGTGGCGGGGCAAGAAGCTGGTGGCC
GCCGCCAGCCCTAGTGCCATGCTCAGCCAGTCCCTGGACCTCAGCGACAGACACCGGGCCACAGGGGCCGCCCTCACGCCCACAGAGGAG
AGGCGCACCTCCTTCTCCACGAGCGACGTCTCCAAGCTCCTCCCGTCCCTGGCCAAGGCTCAGCCTGCAGCAGAAACCACGGACGGAGAG
CGAAGTGCGAAAAAGCCAGCTGTCCAGAAGAAGAAGCCAGGCGACGCATCCTCCCTCCCAGACGCAGGGCTGTCCCCGGGCTCTCAGGTC
GACTCTAAATCCACGTTTAAGAGGCTTTTTCTGCATAAAACCAAGGATAAAAAATACAGCCTGGAGGGCGCAGAGGAGCTGGAGAATGCA
GTGTCCGGGCACGTGGTGCTGGAAGCCACCACCATGAAGAAGGGCCTGGAAGCCCCCTCCGGACAGCAGCATCGCCACGCTGCAGGTGAG
AAGCGCACCAAGGAACCAGGAGGCAAAGGGAAGAAGAACCGAAATGTCAAGATTGGGAAGATCACAGTGTCAGAGAAGTGGCGGGAATCG
GTGTTCCGCCAGATCACCAACGCCAATGAGCTCAAGTACCTGGACGAGTTCCTGCTCAACAAGATAAATGACCTCCGTTCCCAGAAGACG
CCCATTGAGAGCTTGTTTATCGAAGCCACCGAGAAGTTCAGGAGCAACATCAAAACGATGTACTCTGTCCCGAACGGGAAGATCCACGTG
GGCTACAAGGATCTGATGGAGAACTACCAGATCGTCGTCAGCAACCTGGCCACTGAGCGTGGCCAGAAGGACACCAACCTGGTCCTCAAC
CTCTTCCAGTCACTGCTAGATGAGTTCACCCGTGGCTACACCAAGAACGACTTCGAGCCAGTGAAGCAGAGCAAAGCTCAGAAGAAGAAG
CGGAAGCAGGAGCGTGCTGTCCAGGAGCACAACGGGCACGTGTTCGCCAGCTACCAGGTTAGCATCCCGCAGTCGTGCGAGCAGTGCCTC
TCCTATATCTGGCTCATGGACAAGGCCCTGCTCTGCAGCGTGTGCAAGATGACCTGCCACAAGAAGTGCGTGCACAAGATTCAGAGCCAC
TGCTCCTACACCTACGGGAGGAAGGGCGAGCCAGGCGTTGAGCCTGGCCACTTCGGCGTGTGCGTAGACAGCCTGACCAGCGACAAGGCC
TCGGTGCCCATCGTGCTGGAGAAGCTCCTGGAACACGTGGAGATGCACGGCCTGTACACCGAGGGCCTCTACCGCAAGTCGGGTGCTGCC
AACCGCACTCGGGAGCTCCGGCAGGCGCTGCAGACAGACCCCGCAGCAGTCAAGCTGGAGAACTTCCCCATCCACGCCATCACAGGGGTG
CTGAAGCAGTGGCTGCGGGAGCTGCCCGAGCCCCTCATGACCTTCGCACAGTACGGCGACTTCCTCCGAGCCGTCGAGCTGCCGGAGAAG
CAGGAGCAGCTGGCTGCCATCTATGCCGTCCTGGAGCACCTTCCAGAAGCCAACCACAACTCCCTGGAGAGACTCATCTTCCACCTTGTC
AAGGTGGCCCTGCTCGAGGATGTCAACCGCATGTCACCTGGGGCGCTGGCCATTATCTTCGCACCCTGCCTCCTGCGCTGCCCTGACAAC
TCGGACCCGCTGACCAGCATGAAGGACGTCCTCAAGATCACCACGTGCGTGGAGATGCTGATCAAGGAGCAGATGAGGAAATACAAAGTG
AAGATGGAGGAGATCAGCCAACTGGAGGCTGCAGAGAGTATCGCCTTCCGCAGGCTTTCGCTCCTGCGACAAAATGCTCCATGGCCTCTC
AAACTGGGGTTTTCGTCTCCCTATGAGGGGGTCCTGAACAAGAGCCCCAAGACCCGGGACATCCAGGAGGAGGAGCTGGAGGTGCTGCTG
GAGGAGGAGGCAGCCGGCGGCGATGAGGACCGGGAAAAGGAGATTCTCATTGAACGGATCCAGTCCATCAAGGAGGAGAAGGAGGACATC
ACCTACCGGCTGCCGGAGCTGGACCCAAGGGGCTCGGACGAGGAGAACCTGGACTCGGAGACGTCGGCCAGCACCGAGAGCCTGCTGGAG
GAGCGGGCCGGGCGGGGGGCCTCGGAAGGTCAGTATTAAGGGCCCCCTGCGCCTGCTCTCCCTTGCCCCGGCGCGCCCACCCCGAGCCCC
CTCCCCACCGTGGCCGCCCCTCCACGACGAAGGCCGTCGTCCTTCGTAACGGTCAGAGTGAAGACCCCCCGGCGGACCCCCATCATGCCC
ACGGCCAACATCAAGCTCCCACCAGGCCTGCCCTCCCACCTGCCTCGCTGGGCACCGGGTGCCCGGGAGGCGGCTGCCCCAGTGCGGCGC
CGGGAGCCACCTGCCCGCCGCCCGGACCAGATACATTCCGTGTACATCACGCCCGGGGCAGACCTGCCAGTGCAGGGCGCCCTGGAGCCC
CTAGAAGAGGATGGCCAGCCACCTGGGGCCAAGCGGAGGTACTCGGATCCCCCAACGTACTGCCTGCCCCCCGCCTCGGGCCAGACCAAT
GGCTGAGAGCCACAGCTGACAAAGTCTGCATGTCCGAGGACGGCCCCTGCACTGGAGCTGGGCGCCAGAGCTGCAGAGCTAGTGTTCGGC
CCTCAGAGAAGGATCCAGAATCAAAAGCTCAAGAGTGACGTGAGGTGGGCACCGGCCCCAAGTGCAGAGTCAAGGCAGGGAGAGGCCGGC
TGGAGCCAGGCCCCCTCGCACGCAGCCCCCAAATCATGGACGCACCTGTGGGGAGCACCACATCTCCACCTGCGGCCTCACATCTCCCCA
CTCCCCTTTTTGTACGTTTAACTGTTTCTTTGTACGTGGTTTACGTAACTTTAAACTGTAACAGCCTTAATGGAAGACCAAATGGTTTTT
TATATGTGTATGTACAAAGTTTTCTATTAACGCTGCCCGTCTCCCTTATAACCTGGACGTGAGCTGTCAGAGCAGAAGCCACTAGGCCAC
TGCGCGTCTGAGGCTCAGACCCTGCTGTGGTTGGCTTGGGGTGGCCAATGGGCTGGGACCCTCCATGAGAGTTTTGGACACTTGGGTCAC
CTGACCCGTGCCTCTCTGACACATGTCTCCGGGGGGCAGCCACCTGGCCAATGTGCATTTTTGCACATGCTGGAACCTTCCATGGGGGTC
TGGGCTATTGGCTGGAGCCAGGACATGAGTCAGGGGCACCATGGACCTCACGTGCCAGGGAGACTTGAATGTGGCTGTCACTCTTCCGGA
CGCCAAGGGCTGCAGGAGGCTGCTTTTGGCACTACCCACCCCGTGTGACAGAATAGGAGCCAGCGACTCAGGACTGCTCACGGGTCAGGA
GGGCAACGCCTGAAGTCAGACCTCCCTATAGGTCAACAGGGACAACCTGGGGATCTCTGGAGCAGGGCCCTCCTCTCTCAGGCTTGGCCC
ACTCCCCCAGACACCTGGACACGTGGCCACAAATCTGGGACAAGGGGCCCCCGCACAGCATGAAATAAAAAGTGCCTGAGAAGTGTGTGC

>102134_102134_1_ZNF443-MYO9B_ZNF443_chr19_12551726_ENST00000301547_MYO9B_chr19_17303555_ENST00000397274_length(amino acids)=1094AA_BP=9
MGHRGSREMVFLKETERQALQETLHREVVRKILLLQSWFRMVLERRHFLQMKRAAVTIQACWRSYRVRRALERTQAAVYLQASWRGYWQR
KLYRHQKQSIIRLQSLCRGHLQRKSFSQMISEKQKAEEKEREALEAARAGAEEGGQGQAAGGQQVAEQGPEPAEDGGHLASEPEVQPSDR
SPLEHSSPEKEAPSPEKTLPPQKTVAAESHEKVPSSREKRESRRQRGLEHVKFQNKHIQSCKEESALREPSRRVTQEQGVSLLEDKKESR
EDETLLVVETEAENTSQKQPTEQPQAMAVGKVSEETEKTLPSGSPRPGQLERPTSLALDSRVSPPAPGSAPETPEDKSKPCGSPRVQEKP
DSPGGSTQIQRYLDAERLASAVELWRGKKLVAAASPSAMLSQSLDLSDRHRATGAALTPTEERRTSFSTSDVSKLLPSLAKAQPAAETTD
GERSAKKPAVQKKKPGDASSLPDAGLSPGSQVDSKSTFKRLFLHKTKDKKYSLEGAEELENAVSGHVVLEATTMKKGLEAPSGQQHRHAA
GEKRTKEPGGKGKKNRNVKIGKITVSEKWRESVFRQITNANELKYLDEFLLNKINDLRSQKTPIESLFIEATEKFRSNIKTMYSVPNGKI
HVGYKDLMENYQIVVSNLATERGQKDTNLVLNLFQSLLDEFTRGYTKNDFEPVKQSKAQKKKRKQERAVQEHNGHVFASYQVSIPQSCEQ
CLSYIWLMDKALLCSVCKMTCHKKCVHKIQSHCSYTYGRKGEPGVEPGHFGVCVDSLTSDKASVPIVLEKLLEHVEMHGLYTEGLYRKSG
AANRTRELRQALQTDPAAVKLENFPIHAITGVLKQWLRELPEPLMTFAQYGDFLRAVELPEKQEQLAAIYAVLEHLPEANHNSLERLIFH
LVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTSMKDVLKITTCVEMLIKEQMRKYKVKMEEISQLEAAESIAFRRLSLLRQNAPW
PLKLGFSSPYEGVLNKSPKTRDIQEEELEVLLEEEAAGGDEDREKEILIERIQSIKEEKEDITYRLPELDPRGSDEENLDSETSASTESL

--------------------------------------------------------------
>102134_102134_2_ZNF443-MYO9B_ZNF443_chr19_12551726_ENST00000301547_MYO9B_chr19_17303555_ENST00000594824_length(transcript)=4838nt_BP=201nt
AACTGTCAATCAGGCACTGCCCAGAGAAGTGTGTGTGGTTGAAAAAGCCCGCGGCGTCTGCTCCACCCACCTGCGCTCGGCTCTGGGTTC
TGTAGCTGAGAGACGACCTGGAAGTTCTGAGGCAGCCTTTGTCTGGCTGGAACACGCATTGGCAGCGGGAGCTGTCGGTAGGACCTGGGA
CACCGCGGAAGTCGGGAAATGGTCTTCCTGAAGGAGACGGAGCGGCAAGCCCTGCAGGAGACGCTGCACCGGGAGGTGGTGCGGAAAATC
CTGCTGCTGCAGAGCTGGTTCCGGATGGTGCTGGAGCGTCGGCACTTCCTGCAGATGAAGCGGGCCGCCGTCACCATCCAGGCCTGCTGG
CGGTCCTACCGGGTCCGGAGGGCGCTGGAGAGGACGCAGGCTGCCGTGTACCTCCAGGCCTCATGGAGGGGCTACTGGCAGCGGAAGCTC
TACCGGCACCAGAAACAGAGCATCATCCGCCTGCAGAGCCTGTGTCGGGGGCACCTGCAGCGCAAGAGCTTCAGCCAGATGATCTCGGAG
AAGCAGAAGGCAGAAGAGAAGGAGAGGGAAGCCCTGGAAGCCGCAAGAGCAGGTGCTGAGGAGGGCGGACAGGGTCAGGCGGCTGGAGGG
CAGCAGGTAGCTGAGCAGGGGCCGGAGCCAGCGGAGGATGGCGGGCACCTGGCATCGGAGCCTGAGGTGCAGCCAAGTGACAGGTCCCCC
CTAGAGCACTCCTCACCTGAGAAGGAGGCCCCAAGCCCAGAGAAGACTCTCCCACCCCAGAAAACCGTGGCGGCTGAAAGTCACGAGAAA
GTCCCCAGCAGCCGGGAGAAGCGTGAGTCGCGTCGGCAAAGAGGGCTGGAGCACGTCAAGTTCCAGAACAAACACATCCAGTCCTGCAAG
GAGGAGAGTGCCCTCAGAGAACCTTCCAGAAGGGTCACCCAGGAGCAAGGGGTGAGTCTCCTGGAAGACAAAAAGGAGAGCAGAGAAGAT
GAAACCCTTCTAGTCGTAGAGACGGAGGCTGAGAACACATCTCAAAAGCAGCCCACAGAGCAACCCCAGGCCATGGCAGTTGGCAAGGTC
TCTGAAGAAACTGAGAAGACGCTGCCCAGTGGGAGCCCCAGGCCTGGCCAGTTGGAGCGGCCGACCAGCCTGGCCCTGGACAGCAGGGTC
AGCCCACCGGCCCCTGGCAGCGCCCCCGAGACCCCCGAGGACAAGAGCAAACCATGTGGCAGCCCAAGGGTTCAGGAAAAGCCCGACAGC
CCCGGAGGCTCCACGCAGATCCAGCGGTACCTGGACGCCGAGCGGCTGGCCAGCGCCGTGGAACTGTGGCGGGGCAAGAAGCTGGTGGCC
GCCGCCAGCCCTAGTGCCATGCTCAGCCAGTCCCTGGACCTCAGCGACAGACACCGGGCCACAGGGGCCGCCCTCACGCCCACAGAGGAG
AGGCGCACCTCCTTCTCCACGAGCGACGTCTCCAAGCTCCTCCCGTCCCTGGCCAAGGCTCAGCCTGCAGCAGAAACCACGGACGGAGAG
CGAAGTGCGAAAAAGCCAGCTGTCCAGAAGAAGAAGCCAGGCGACGCATCCTCCCTCCCAGACGCAGGGCTGTCCCCGGGCTCTCAGGTC
GACTCTAAATCCACGTTTAAGAGGCTTTTTCTGCATAAAACCAAGGATAAAAAATACAGCCTGGAGGGCGCAGAGGAGCTGGAGAATGCA
GTGTCCGGGCACGTGGTGCTGGAAGCCACCACCATGAAGAAGGGCCTGGAAGCCCCCTCCGGACAGCAGCATCGCCACGCTGCAGGTGAG
AAGCGCACCAAGGAACCAGGAGGCAAAGGGAAGAAGAACCGAAATGTCAAGATTGGGAAGATCACAGTGTCAGAGAAGTGGCGGGAATCG
GTGTTCCGCCAGATCACCAACGCCAATGAGCTCAAGTACCTGGACGAGTTCCTGCTCAACAAGATAAATGACCTCCGTTCCCAGAAGACG
CCCATTGAGAGCTTGTTTATCGAAGCCACCGAGAAGTTCAGGAGCAACATCAAAACGATGTACTCTGTCCCGAACGGGAAGATCCACGTG
GGCTACAAGGATCTGATGGAGAACTACCAGATCGTCGTCAGCAACCTGGCCACTGAGCGTGGCCAGAAGGACACCAACCTGGTCCTCAAC
CTCTTCCAGTCACTGCTAGATGAGTTCACCCGTGGCTACACCAAGAACGACTTCGAGCCAGTGAAGCAGAGCAAAGCTCAGAAGAAGAAG
CGGAAGCAGGAGCGTGCTGTCCAGGAGCACAACGGGCACGTGTTCGCCAGCTACCAGGTTAGCATCCCGCAGTCGTGCGAGCAGTGCCTC
TCCTATATCTGGCTCATGGACAAGGCCCTGCTCTGCAGCGTGTGCAAGATGACCTGCCACAAGAAGTGCGTGCACAAGATTCAGAGCCAC
TGCTCCTACACCTACGGGAGGAAGGGCGAGCCAGGCGTTGAGCCTGGCCACTTCGGCGTGTGCGTAGACAGCCTGACCAGCGACAAGGCC
TCGGTGCCCATCGTGCTGGAGAAGCTCCTGGAACACGTGGAGATGCACGGCCTGTACACCGAGGGCCTCTACCGCAAGTCGGGTGCTGCC
AACCGCACTCGGGAGCTCCGGCAGGCGCTGCAGACAGACCCCGCAGCAGTCAAGCTGGAGAACTTCCCCATCCACGCCATCACAGGGGTG
CTGAAGCAGTGGCTGCGGGAGCTGCCCGAGCCCCTCATGACCTTCGCACAGTACGGCGACTTCCTCCGAGCCGTCGAGCTGCCGGAGAAG
CAGGAGCAGCTGGCTGCCATCTATGCCGTCCTGGAGCACCTTCCAGAAGCCAACCACAACTCCCTGGAGAGACTCATCTTCCACCTTGTC
AAGGTGGCCCTGCTCGAGGATGTCAACCGCATGTCACCTGGGGCGCTGGCCATTATCTTCGCACCCTGCCTCCTGCGCTGCCCTGACAAC
TCGGACCCGCTGACCAGCATGAAGGACGTCCTCAAGATCACCACGTGCGTGGAGATGCTGATCAAGGAGCAGATGAGGAAATACAAAGTG
AAGATGGAGGAGATCAGCCAACTGGAGGCTGCAGAGAGTATCGCCTTCCGCAGGCTTTCGCTCCTGCGACAAAATGCTCCATGGCCTCTC
AAACTGGGGTTTTCGTCTCCCTATGAGGGGGTCCTGAACAAGAGCCCCAAGACCCGGGACATCCAGGAGGAGGAGCTGGAGGTGCTGCTG
GAGGAGGAGGCAGCCGGCGGCGATGAGGACCGGGAAAAGGAGATTCTCATTGAACGGATCCAGTCCATCAAGGAGGAGAAGCAAGACATC
ACCTACCGGCTGCCGGAGCTGGACCCAAGGGGCTCGGACGAGGAGAACCTGGACTCGGAGACGTCGGCCAGCACCGAGAGCCTGCTGGAG
GAGCGGGCCGGGCGGGGGGCCTCGGAAGGGCCCCCTGCGCCTGCTCTCCCTTGCCCCGGCGCGCCCACCCCGAGCCCCCTCCCCACCGTG
GCCGCCCCTCCACGACGAAGGCCGTCGTCCTTCGTAACGGTCAGAGTGAAGACCCCCCGGCGGACCCCCATCATGCCCACGGCCAACATC
AAGCTCCCACCAGGCCTGCCCTCCCACCTGCCTCGCTGGGCACCGGGTGCCCGGGAGGCGGCTGCCCCAGTGCGGCGCCGGGAGCCACCT
GCCCGCCGCCCGGACCAGATACATTCCGTGTACATCACGCCCGGGGCAGACCTGCCAGTGCAGGGCGCCCTGGAGCCCCTAGAAGAGGAT
GGCCAGCCACCTGGGGCCAAGCGGAGGTACTCGGATCCCCCAACGTACTGCCTGCCCCCCGCCTCGGGCCAGACCAATGGCTGAGAGCCA
CAGCTGACAAAGTCTGCATGTCCGAGGACGGCCCCTGCACTGGAGCTGGGCGCCAGAGCTGCAGAGCTAGTGTTCGGCCCTCAGAGAAGG
ATCCAGAATCAAAAGCTCAAGAGTGACGTGAGGTGGGCACCGGCCCCAAGTGCAGAGTCAAGGCAGGGAGAGGCCGGCTGGAGCCAGGCC
CCCTCGCACGCAGCCCCCAAATCATGGACGCACCTGTGGGGAGCACCACATCTCCACCTGCGGCCTCACATCTCCCCACTCCCCTTTTTG
TACGTTTAACTGTTTCTTTGTACGTGGTTTACGTAACTTTAAACTGTAACAGCCTTAATGGAAGACCAAATGGTTTTTTATATGTGTATG
TACAAAGTTTTCTATTAACGCTGCCCGTCTCCCTTATAACCTGGACGTGAGCTGTCAGAGCAGAAGCCACTAGGCCACTGCGCGTCTGAG
GCTCAGACCCTGCTGTGGTTGGCTTGGGGTGGCCAATGGGCTGGGACCCTCCATGAGAGTTTTGGACACTTGGGTCACCTGACCCGTGCC
TCTCTGACACATGTCTCCGGGGGGCAGCCACCTGGCCAATGTGCATTTTTGCACATGCTGGAACCTTCCATGGGGGTCTGGGCTATTGGC
TGGAGCCAGGACATGAGTCAGGGGCACCATGGACCTCACGTGCCAGGGAGACTTGAATGTGGCTGTCACTCTTCCGGACGCCAAGGGCTG
CAGGAGGCTGCTTTTGGCACTACCCACCCCGTGTGACAGAATAGGAGCCAGCGACTCAGGACTGCTCACGGGTCAGGAGGGCAACGCCTG
AAGTCAGACCTCCCTATAGGTCAACAGGGACAACCTGGGGATCTCTGGAGCAGGGCCCTCCTCTCTCAGGCTTGGCCCACTCCCCCAGAC

>102134_102134_2_ZNF443-MYO9B_ZNF443_chr19_12551726_ENST00000301547_MYO9B_chr19_17303555_ENST00000594824_length(amino acids)=1229AA_BP=9
MGHRGSREMVFLKETERQALQETLHREVVRKILLLQSWFRMVLERRHFLQMKRAAVTIQACWRSYRVRRALERTQAAVYLQASWRGYWQR
KLYRHQKQSIIRLQSLCRGHLQRKSFSQMISEKQKAEEKEREALEAARAGAEEGGQGQAAGGQQVAEQGPEPAEDGGHLASEPEVQPSDR
SPLEHSSPEKEAPSPEKTLPPQKTVAAESHEKVPSSREKRESRRQRGLEHVKFQNKHIQSCKEESALREPSRRVTQEQGVSLLEDKKESR
EDETLLVVETEAENTSQKQPTEQPQAMAVGKVSEETEKTLPSGSPRPGQLERPTSLALDSRVSPPAPGSAPETPEDKSKPCGSPRVQEKP
DSPGGSTQIQRYLDAERLASAVELWRGKKLVAAASPSAMLSQSLDLSDRHRATGAALTPTEERRTSFSTSDVSKLLPSLAKAQPAAETTD
GERSAKKPAVQKKKPGDASSLPDAGLSPGSQVDSKSTFKRLFLHKTKDKKYSLEGAEELENAVSGHVVLEATTMKKGLEAPSGQQHRHAA
GEKRTKEPGGKGKKNRNVKIGKITVSEKWRESVFRQITNANELKYLDEFLLNKINDLRSQKTPIESLFIEATEKFRSNIKTMYSVPNGKI
HVGYKDLMENYQIVVSNLATERGQKDTNLVLNLFQSLLDEFTRGYTKNDFEPVKQSKAQKKKRKQERAVQEHNGHVFASYQVSIPQSCEQ
CLSYIWLMDKALLCSVCKMTCHKKCVHKIQSHCSYTYGRKGEPGVEPGHFGVCVDSLTSDKASVPIVLEKLLEHVEMHGLYTEGLYRKSG
AANRTRELRQALQTDPAAVKLENFPIHAITGVLKQWLRELPEPLMTFAQYGDFLRAVELPEKQEQLAAIYAVLEHLPEANHNSLERLIFH
LVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTSMKDVLKITTCVEMLIKEQMRKYKVKMEEISQLEAAESIAFRRLSLLRQNAPW
PLKLGFSSPYEGVLNKSPKTRDIQEEELEVLLEEEAAGGDEDREKEILIERIQSIKEEKQDITYRLPELDPRGSDEENLDSETSASTESL
LEERAGRGASEGPPAPALPCPGAPTPSPLPTVAAPPRRRPSSFVTVRVKTPRRTPIMPTANIKLPPGLPSHLPRWAPGAREAAAPVRRRE

--------------------------------------------------------------
>102134_102134_3_ZNF443-MYO9B_ZNF443_chr19_12551726_ENST00000301547_MYO9B_chr19_17303555_ENST00000595618_length(transcript)=4861nt_BP=201nt
AACTGTCAATCAGGCACTGCCCAGAGAAGTGTGTGTGGTTGAAAAAGCCCGCGGCGTCTGCTCCACCCACCTGCGCTCGGCTCTGGGTTC
TGTAGCTGAGAGACGACCTGGAAGTTCTGAGGCAGCCTTTGTCTGGCTGGAACACGCATTGGCAGCGGGAGCTGTCGGTAGGACCTGGGA
CACCGCGGAAGTCGGGAAATGGTCTTCCTGAAGGAGACGGAGCGGCAAGCCCTGCAGGAGACGCTGCACCGGGAGGTGGTGCGGAAAATC
CTGCTGCTGCAGAGCTGGTTCCGGATGGTGCTGGAGCGTCGGCACTTCCTGCAGATGAAGCGGGCCGCCGTCACCATCCAGGCCTGCTGG
CGGTCCTACCGGGTCCGGAGGGCGCTGGAGAGGACGCAGGCTGCCGTGTACCTCCAGGCCTCATGGAGGGGCTACTGGCAGCGGAAGCTC
TACCGGCACCAGAAACAGAGCATCATCCGCCTGCAGAGCCTGTGTCGGGGGCACCTGCAGCGCAAGAGCTTCAGCCAGATGATCTCGGAG
AAGCAGAAGGCAGAAGAGAAGGAGAGGGAAGCCCTGGAAGCCGCAAGAGCAGGTGCTGAGGAGGGCGGACAGGGTCAGGCGGCTGGAGGG
CAGCAGGTAGCTGAGCAGGGGCCGGAGCCAGCGGAGGATGGCGGGCACCTGGCATCGGAGCCTGAGGTGCAGCCAAGTGACAGGTCCCCC
CTAGAGCACTCCTCACCTGAGAAGGAGGCCCCAAGCCCAGAGAAGACTCTCCCACCCCAGAAAACCGTGGCGGCTGAAAGTCACGAGAAA
GTCCCCAGCAGCCGGGAGAAGCGTGAGTCGCGTCGGCAAAGAGGGCTGGAGCACGTCAAGTTCCAGAACAAACACATCCAGTCCTGCAAG
GAGGAGAGTGCCCTCAGAGAACCTTCCAGAAGGGTCACCCAGGAGCAAGGGGTGAGTCTCCTGGAAGACAAAAAGGAGAGCAGAGAAGAT
GAAACCCTTCTAGTCGTAGAGACGGAGGCTGAGAACACATCTCAAAAGCAGCCCACAGAGCAACCCCAGGCCATGGCAGTTGGCAAGGTC
TCTGAAGAAACTGAGAAGACGCTGCCCAGTGGGAGCCCCAGGCCTGGCCAGTTGGAGCGGCCGACCAGCCTGGCCCTGGACAGCAGGGTC
AGCCCACCGGCCCCTGGCAGCGCCCCCGAGACCCCCGAGGACAAGAGCAAACCATGTGGCAGCCCAAGGGTTCAGGAAAAGCCCGACAGC
CCCGGAGGCTCCACGCAGATCCAGCGGTACCTGGACGCCGAGCGGCTGGCCAGCGCCGTGGAACTGTGGCGGGGCAAGAAGCTGGTGGCC
GCCGCCAGCCCTAGTGCCATGCTCAGCCAGTCCCTGGACCTCAGCGACAGACACCGGGCCACAGGGGCCGCCCTCACGCCCACAGAGGAG
AGGCGCACCTCCTTCTCCACGAGCGACGTCTCCAAGCTCCTCCCGTCCCTGGCCAAGGCTCAGCCTGCAGCAGAAACCACGGACGGAGAG
CGAAGTGCGAAAAAGCCAGCTGTCCAGAAGAAGAAGCCAGGCGACGCATCCTCCCTCCCAGACGCAGGGCTGTCCCCGGGCTCTCAGGTC
GACTCTAAATCCACGTTTAAGAGGCTTTTTCTGCATAAAACCAAGGATAAAAAATACAGCCTGGAGGGCGCAGAGGAGCTGGAGAATGCA
GTGTCCGGGCACGTGGTGCTGGAAGCCACCACCATGAAGAAGGGCCTGGAAGCCCCCTCCGGACAGCAGCATCGCCACGCTGCAGGTGAG
AAGCGCACCAAGGAACCAGGAGGCAAAGGGAAGAAGAACCGAAATGTCAAGATTGGGAAGATCACAGTGTCAGAGAAGTGGCGGGAATCG
GTGTTCCGCCAGATCACCAACGCCAATGAGCTCAAGTACCTGGACGAGTTCCTGCTCAACAAGATAAATGACCTCCGTTCCCAGAAGACG
CCCATTGAGAGCTTGTTTATCGAAGCCACCGAGAAGTTCAGGAGCAACATCAAAACGATGTACTCTGTCCCGAACGGGAAGATCCACGTG
GGCTACAAGGATCTGATGGAGAACTACCAGATCGTCGTCAGCAACCTGGCCACTGAGCGTGGCCAGAAGGACACCAACCTGGTCCTCAAC
CTCTTCCAGTCACTGCTAGATGAGTTCACCCGTGGCTACACCAAGAACGACTTCGAGCCAGTGAAGCAGAGCAAAGCTCAGAAGAAGAAG
CGGAAGCAGGAGCGTGCTGTCCAGGAGCACAACGGGCACGTGTTCGCCAGCTACCAGGTTAGCATCCCGCAGTCGTGCGAGCAGTGCCTC
TCCTATATCTGGCTCATGGACAAGGCCCTGCTCTGCAGCGTGTGCAAGATGACCTGCCACAAGAAGTGCGTGCACAAGATTCAGAGCCAC
TGCTCCTACACCTACGGGAGGAAGGGCGAGCCAGGCGTTGAGCCTGGCCACTTCGGCGTGTGCGTAGACAGCCTGACCAGCGACAAGGCC
TCGGTGCCCATCGTGCTGGAGAAGCTCCTGGAACACGTGGAGATGCACGGCCTGTACACCGAGGGCCTCTACCGCAAGTCGGGTGCTGCC
AACCGCACTCGGGAGCTCCGGCAGGCGCTGCAGACAGACCCCGCAGCAGTCAAGCTGGAGAACTTCCCCATCCACGCCATCACAGGGGTG
CTGAAGCAGTGGCTGCGGGAGCTGCCCGAGCCCCTCATGACCTTCGCACAGTACGGCGACTTCCTCCGAGCCGTCGAGCTGCCGGAGAAG
CAGGAGCAGCTGGCTGCCATCTATGCCGTCCTGGAGCACCTTCCAGAAGCCAACCACAACTCCCTGGAGAGACTCATCTTCCACCTTGTC
AAGGTGGCCCTGCTCGAGGATGTCAACCGCATGTCACCTGGGGCGCTGGCCATTATCTTCGCACCCTGCCTCCTGCGCTGCCCTGACAAC
TCGGACCCGCTGACCAGCATGAAGGACGTCCTCAAGATCACCACGTGCGTGGAGATGCTGATCAAGGAGCAGATGAGGAAATACAAAGTG
AAGATGGAGGAGATCAGCCAACTGGAGGCTGCAGAGAGTATCGCCTTCCGCAGGCTTTCGCTCCTGCGACAAAATGCTCCATGGCCTCTC
AAACTGGGGTTTTCGTCTCCCTATGAGGGGGTCCTGAACAAGAGCCCCAAGACCCGGGACATCCAGGAGGAGGAGCTGGAGGTGCTGCTG
GAGGAGGAGGCAGCCGGCGGCGATGAGGACCGGGAAAAGGAGATTCTCATTGAACGGATCCAGTCCATCAAGGAGGAGAAGGAGGACATC
ACCTACCGGCTGCCGGAGCTGGACCCAAGGGGCTCGGACGAGGAGAACCTGGACTCGGAGACGTCGGCCAGCACCGAGAGCCTGCTGGAG
GAGCGGGCCGGGCGGGGGGCCTCGGAAGGTCAGTATTAAGGGCCCCCTGCGCCTGCTCTCCCTTGCCCCGGCGCGCCCACCCCGAGCCCC
CTCCCCACCGTGGCCGCCCCTCCACGACGAAGGCCGTCGTCCTTCGTAACGGTCAGAGTGAAGACCCCCCGGCGGACCCCCATCATGCCC
ACGGCCAACATCAAGCTCCCACCAGGCCTGCCCTCCCACCTGCCTCGCTGGGCACCGGGTGCCCGGGAGGCGGCTGCCCCAGTGCGGCGC
CGGGAGCCACCTGCCCGCCGCCCGGACCAGATACATTCCGTGTACATCACGCCCGGGGCAGACCTGCCAGTGCAGGGCGCCCTGGAGCCC
CTAGAAGAGGATGGCCAGCCACCTGGGGCCAAGCGGAGGTACTCGGATCCCCCAACGTACTGCCTGCCCCCCGCCTCGGGCCAGACCAAT
GGCTGAGAGCCACAGCTGACAAAGTCTGCATGTCCGAGGACGGCCCCTGCACTGGAGCTGGGCGCCAGAGCTGCAGAGCTAGTGTTCGGC
CCTCAGAGAAGGATCCAGAATCAAAAGCTCAAGAGTGACGTGAGGTGGGCACCGGCCCCAAGTGCAGAGTCAAGGCAGGGAGAGGCCGGC
TGGAGCCAGGCCCCCTCGCACGCAGCCCCCAAATCATGGACGCACCTGTGGGGAGCACCACATCTCCACCTGCGGCCTCACATCTCCCCA
CTCCCCTTTTTGTACGTTTAACTGTTTCTTTGTACGTGGTTTACGTAACTTTAAACTGTAACAGCCTTAATGGAAGACCAAATGGTTTTT
TATATGTGTATGTACAAAGTTTTCTATTAACGCTGCCCGTCTCCCTTATAACCTGGACGTGAGCTGTCAGAGCAGAAGCCACTAGGCCAC
TGCGCGTCTGAGGCTCAGACCCTGCTGTGGTTGGCTTGGGGTGGCCAATGGGCTGGGACCCTCCATGAGAGTTTTGGACACTTGGGTCAC
CTGACCCGTGCCTCTCTGACACATGTCTCCGGGGGGCAGCCACCTGGCCAATGTGCATTTTTGCACATGCTGGAACCTTCCATGGGGGTC
TGGGCTATTGGCTGGAGCCAGGACATGAGTCAGGGGCACCATGGACCTCACGTGCCAGGGAGACTTGAATGTGGCTGTCACTCTTCCGGA
CGCCAAGGGCTGCAGGAGGCTGCTTTTGGCACTACCCACCCCGTGTGACAGAATAGGAGCCAGCGACTCAGGACTGCTCACGGGTCAGGA
GGGCAACGCCTGAAGTCAGACCTCCCTATAGGTCAACAGGGACAACCTGGGGATCTCTGGAGCAGGGCCCTCCTCTCTCAGGCTTGGCCC
ACTCCCCCAGACACCTGGACACGTGGCCACAAATCTGGGACAAGGGGCCCCCGCACAGCATGAAATAAAAAGTGCCTGAGAAGTGTGTGC

>102134_102134_3_ZNF443-MYO9B_ZNF443_chr19_12551726_ENST00000301547_MYO9B_chr19_17303555_ENST00000595618_length(amino acids)=1094AA_BP=9
MGHRGSREMVFLKETERQALQETLHREVVRKILLLQSWFRMVLERRHFLQMKRAAVTIQACWRSYRVRRALERTQAAVYLQASWRGYWQR
KLYRHQKQSIIRLQSLCRGHLQRKSFSQMISEKQKAEEKEREALEAARAGAEEGGQGQAAGGQQVAEQGPEPAEDGGHLASEPEVQPSDR
SPLEHSSPEKEAPSPEKTLPPQKTVAAESHEKVPSSREKRESRRQRGLEHVKFQNKHIQSCKEESALREPSRRVTQEQGVSLLEDKKESR
EDETLLVVETEAENTSQKQPTEQPQAMAVGKVSEETEKTLPSGSPRPGQLERPTSLALDSRVSPPAPGSAPETPEDKSKPCGSPRVQEKP
DSPGGSTQIQRYLDAERLASAVELWRGKKLVAAASPSAMLSQSLDLSDRHRATGAALTPTEERRTSFSTSDVSKLLPSLAKAQPAAETTD
GERSAKKPAVQKKKPGDASSLPDAGLSPGSQVDSKSTFKRLFLHKTKDKKYSLEGAEELENAVSGHVVLEATTMKKGLEAPSGQQHRHAA
GEKRTKEPGGKGKKNRNVKIGKITVSEKWRESVFRQITNANELKYLDEFLLNKINDLRSQKTPIESLFIEATEKFRSNIKTMYSVPNGKI
HVGYKDLMENYQIVVSNLATERGQKDTNLVLNLFQSLLDEFTRGYTKNDFEPVKQSKAQKKKRKQERAVQEHNGHVFASYQVSIPQSCEQ
CLSYIWLMDKALLCSVCKMTCHKKCVHKIQSHCSYTYGRKGEPGVEPGHFGVCVDSLTSDKASVPIVLEKLLEHVEMHGLYTEGLYRKSG
AANRTRELRQALQTDPAAVKLENFPIHAITGVLKQWLRELPEPLMTFAQYGDFLRAVELPEKQEQLAAIYAVLEHLPEANHNSLERLIFH
LVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTSMKDVLKITTCVEMLIKEQMRKYKVKMEEISQLEAAESIAFRRLSLLRQNAPW
PLKLGFSSPYEGVLNKSPKTRDIQEEELEVLLEEEAAGGDEDREKEILIERIQSIKEEKEDITYRLPELDPRGSDEENLDSETSASTESL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZNF443-MYO9B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneMYO9Bchr19:12551726chr19:17303555ENST0000039727418391739_1744937.02189.0RHOA
TgeneMYO9Bchr19:12551726chr19:17303555ENST0000059561819401739_1744937.02458.6666666666665RHOA


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF443-MYO9B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF443-MYO9B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource