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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ZNF480-ELL (FusionGDB2 ID:102184)

Fusion Gene Summary for ZNF480-ELL

Fusion gene summary

Fusion gene information	Fusion gene name: ZNF480-ELL
	Fusion gene ID: 102184
		Hgene	Tgene
	Gene symbol	ZNF480	ELL
	Gene ID	147657	8178
	Gene name	zinc finger protein 480	elongation factor for RNA polymerase II
	Synonyms	-	C19orf17\|ELL1\|MEN\|PPP1R68
	Cytomap	19q13.41	19p13.11
	Type of gene	protein-coding	protein-coding
	Description	zinc finger protein 480	RNA polymerase II elongation factor ELLELL gene (11-19 lysine-rich leukemia gene)ELL/KMT2A fusionELL/KMT2A fusion proteinKMT2A/ELL fusionKMT2A/ELL fusion proteineleven-nineteen lysine-rich leukemia proteinelongation factor RNA polymerase IIprotein
	Modification date	20200313	20200319
	UniProtAcc	.	O00472
	Ensembl transtripts involved in fusion gene	ENST00000335090, ENST00000595962, ENST00000334564, ENST00000490272,	ENST00000262809, ENST00000596124,
Fusion gene scores	* DoF score	4 X 2 X 4=32	11 X 17 X 7=1309
	# samples	4	21
	** MAII score	log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(21/1309*10)=-2.64000386427912 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ZNF480 [Title/Abstract] AND ELL [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ZNF480(52819215)-ELL(18572662), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ELL	GO:0010923	negative regulation of phosphatase activity	19389623

Fusion gene breakpoints across ZNF480 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ELL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-HF-7134	ZNF480	chr19	52819215	+	ELL	chr19	18572662	-

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Fusion Gene ORF analysis for ZNF480-ELL

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000335090	ENST00000262809	ZNF480	chr19	52819215	+	ELL	chr19	18572662	-
In-frame	ENST00000335090	ENST00000596124	ZNF480	chr19	52819215	+	ELL	chr19	18572662	-
In-frame	ENST00000595962	ENST00000262809	ZNF480	chr19	52819215	+	ELL	chr19	18572662	-
In-frame	ENST00000595962	ENST00000596124	ZNF480	chr19	52819215	+	ELL	chr19	18572662	-
intron-3CDS	ENST00000334564	ENST00000262809	ZNF480	chr19	52819215	+	ELL	chr19	18572662	-
intron-3CDS	ENST00000334564	ENST00000596124	ZNF480	chr19	52819215	+	ELL	chr19	18572662	-
intron-3CDS	ENST00000490272	ENST00000262809	ZNF480	chr19	52819215	+	ELL	chr19	18572662	-
intron-3CDS	ENST00000490272	ENST00000596124	ZNF480	chr19	52819215	+	ELL	chr19	18572662	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000595962	ZNF480	chr19	52819215	+	ENST00000262809	ELL	chr19	18572662	-	3880	394	66	1790	574
ENST00000595962	ZNF480	chr19	52819215	+	ENST00000596124	ELL	chr19	18572662	-	1792	394	66	1790	574
ENST00000335090	ZNF480	chr19	52819215	+	ENST00000262809	ELL	chr19	18572662	-	3706	220	108	1616	502
ENST00000335090	ZNF480	chr19	52819215	+	ENST00000596124	ELL	chr19	18572662	-	1618	220	108	1616	502

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000595962	ENST00000262809	ZNF480	chr19	52819215	+	ELL	chr19	18572662	-	0.012542358	0.9874577
ENST00000595962	ENST00000596124	ZNF480	chr19	52819215	+	ELL	chr19	18572662	-	0.059413243	0.94058675
ENST00000335090	ENST00000262809	ZNF480	chr19	52819215	+	ELL	chr19	18572662	-	0.015285355	0.9847147
ENST00000335090	ENST00000596124	ZNF480	chr19	52819215	+	ELL	chr19	18572662	-	0.069568254	0.9304317

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Fusion Genomic Features for ZNF480-ELL

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF480-ELL

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:52819215/chr19:18572662)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ELL O00472
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression. {ECO:0000269\|PubMed:20159561, ECO:0000269\|PubMed:20471948, ECO:0000269\|PubMed:22195968, ECO:0000269\|PubMed:23251033}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ZNF480

chr19:52819215

chr19:18572662

ENST00000595962

27_98

109

536.0

Domain

KRAB

Tgene

ELL

chr19:52819215

chr19:18572662

ENST00000262809

445_459

156

622.0

Motif

Nuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ZNF480

chr19:52819215

chr19:18572662

ENST00000335090

27_98

459.0

Domain

KRAB

Hgene

ZNF480

chr19:52819215

chr19:18572662

ENST00000335090

203_225

459.0

Zinc finger

C2H2-type 1%3B atypical

Hgene

ZNF480

chr19:52819215

chr19:18572662

ENST00000335090

231_253

459.0

Zinc finger

C2H2-type 2

Hgene

ZNF480

chr19:52819215

chr19:18572662

ENST00000335090

259_281

459.0

Zinc finger

C2H2-type 3

Hgene

ZNF480

chr19:52819215

chr19:18572662

ENST00000335090

287_309

459.0

Zinc finger

C2H2-type 4

Hgene

ZNF480

chr19:52819215

chr19:18572662

ENST00000335090

315_337

459.0

Zinc finger

C2H2-type 5%3B degenerate

Hgene

ZNF480

chr19:52819215

chr19:18572662

ENST00000335090

343_365

459.0

Zinc finger

C2H2-type 6

Hgene

ZNF480

chr19:52819215

chr19:18572662

ENST00000335090

371_393

459.0

Zinc finger

C2H2-type 7

Hgene

ZNF480

chr19:52819215

chr19:18572662

ENST00000335090

399_421

459.0

Zinc finger

C2H2-type 8

Hgene

ZNF480

chr19:52819215

chr19:18572662

ENST00000335090

427_449

459.0

Zinc finger

C2H2-type 9

Hgene

ZNF480

chr19:52819215

chr19:18572662

ENST00000335090

455_477

459.0

Zinc finger

C2H2-type 10

Hgene

ZNF480

chr19:52819215

chr19:18572662

ENST00000335090

483_505

459.0

Zinc finger

C2H2-type 11

Hgene

ZNF480

chr19:52819215

chr19:18572662

ENST00000335090

511_533

459.0

Zinc finger

C2H2-type 12

Hgene

ZNF480

chr19:52819215

chr19:18572662

ENST00000595962

203_225

109

536.0

Zinc finger

C2H2-type 1%3B atypical

Hgene

ZNF480

chr19:52819215

chr19:18572662

ENST00000595962

231_253

109

536.0

Zinc finger

C2H2-type 2

Hgene

ZNF480

chr19:52819215

chr19:18572662

ENST00000595962

259_281

109

536.0

Zinc finger

C2H2-type 3

Hgene

ZNF480

chr19:52819215

chr19:18572662

ENST00000595962

287_309

109

536.0

Zinc finger

C2H2-type 4

Hgene

ZNF480

chr19:52819215

chr19:18572662

ENST00000595962

315_337

109

536.0

Zinc finger

C2H2-type 5%3B degenerate

Hgene

ZNF480

chr19:52819215

chr19:18572662

ENST00000595962

343_365

109

536.0

Zinc finger

C2H2-type 6

Hgene

ZNF480

chr19:52819215

chr19:18572662

ENST00000595962

371_393

109

536.0

Zinc finger

C2H2-type 7

Hgene

ZNF480

chr19:52819215

chr19:18572662

ENST00000595962

399_421

109

536.0

Zinc finger

C2H2-type 8

Hgene

ZNF480

chr19:52819215

chr19:18572662

ENST00000595962

427_449

109

536.0

Zinc finger

C2H2-type 9

Hgene

ZNF480

chr19:52819215

chr19:18572662

ENST00000595962

455_477

109

536.0

Zinc finger

C2H2-type 10

Hgene

ZNF480

chr19:52819215

chr19:18572662

ENST00000595962

483_505

109

536.0

Zinc finger

C2H2-type 11

Hgene

ZNF480

chr19:52819215

chr19:18572662

ENST00000595962

511_533

109

536.0

Zinc finger

C2H2-type 12

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Fusion Gene Sequence for ZNF480-ELL

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>102184_102184_1_ZNF480-ELL_ZNF480_chr19_52819215_ENST00000335090_ELL_chr19_18572662_ENST00000262809_length(transcript)=3706nt_BP=220nt
GATTGACTTCTAAAGAGTCATGCTGTGTGATGAAAAAGCCCAGAAGAGAAGGAAGAGGAAAGCAAAGGAGTCAGGGATGGCTCTTCCTCA
GGAATCTCTCTTCCTGACCTGAATATTAACTCCATGTTGGAGCAAAGGAGGGAGCCCTGGTCTGGTGAGAGTGAAGTGAAAATAGCAAAA
AATTCAGATGGGAGGGAGTGCATCAAAGGTGTGAACACAGGCAAGAAGGTTCAGTTTCGGAAACCAGCCCCAGGTGCAACAGACGCGGTG
CCCTCCCGGAAGCGGGCAACCCCCATCAACTTGGCGAGTGCCATCAGGAAGAGTGGTGCCAGTGCCGTGAGTGGGGGCAGCGGGGTGTCC
CAGAGGCCCTTCCGTGACCGAGTGCTGCACCTCCTGGCACTACGGCCCTACCGCAAGGCTGAGCTGCTGCTGCGACTGCAGAAGGACGGC
CTGACGCAGGCGGACAAGGACGCGCTGGATGGCCTCCTCCAGCAGGTGGCCAACATGAGTGCTAAGGACGGCACGTGTACACTGCAGGAC
TGCATGTACAAGGATGTGCAGAAGGACTGGCCTGGCTACTCGGAGGGGGACCAGCAGCTGCTGAAGCGGGTGCTCGTCCGGAAGCTGTGC
CAGCCACAGAGCACTGGCAGCCTCCTTGGAGACCCTGCTGCCTCCAGCCCCCCAGGCGAGCGTGGGCGCTCGGCCTCGCCCCCACAGAAG
CGGCTGCAGCCTCCTGATTTCATCGACCCCCTAGCCAACAAGAAACCCCGGATATCGCACTTCACTCAGAGAGCTCAGCCTGCCGTCAAC
GGGAAGCTGGGCGTGCCCAATGGCCGTGAGGCCTTGCTGCCCACCCCGGGCCCACCAGCCAGCACGGACACCCTCAGCTCCAGCACTCAC
CTGCCCCCGCGGCTGGAGCCCCCGAGGGCCCACGACCCCCTGGCCGATGTCAGCAATGACCTGGGCCACAGCGGCCGAGACTGTGAGCAC
GGAGAGGCGGCTGCCCCAGCCCCCACTGTGCGCCTCGGCCTGCCCCTGCTGACGGACTGTGCCCAGCCCAGCAGGCCACACGGCAGCCCC
TCGCGCAGCAAGCCCAAGAAGAAGTCCAAGAAGCACAAAGACAAGGAGAGGGCGGCTGAGGACAAGCCCCGGGCCCAGCTTCCAGACTGT
GCACCTGCCACCCATGCCACCCCCGGAGCCCCAGCAGACACCCCAGGTTTAAACGGAACCTGCAGCGTTTCCAGTGTTCCCACGTCCACG
TCGGAGACGCCTGACTACTTGCTGAAGTACGCAGCCATCTCCTCTTCGGAGCAGCGCCAGAGCTACAAGAACGACTTCAATGCCGAGTAC
AGCGAGTACCGCGACCTGCACGCCCGCATTGAGCGCATCACGCGGCGGTTCACCCAGCTCGACGCCCAGCTCCGGCAGCTCTCCCAGGGC
TCCGAGGAGTATGAGACTACTCGAGGGCAGATTTTGCAGGAATATCGAAAAATCAAAAAGACCAACACCAACTACAGCCAGGAGAAGCAC
CGCTGCGAGTACCTGCACAGCAAGCTGGCCCACATCAAGAGGCTCATCGCCGAGTACGACCAGCGGCAGCTGCAGGCTTGGCCCTAGCCG
CCCTCCCCGATGGCGGGGATCTGGGAGGGTCGGGGGAGCAAAAGGCGGTGAGAGAGGATTTATTTAAAAAAATAAACCCGAGGAAGATGC
TCATCTGAGCCAGCACCGCCGGCTTTCAGGGCAGCCCCTGCAGACGTCTGGCCCTGGCGGGTGGCTGCAAGCCCACCTCGGCCCTCCCTG
CGCTTCCTGAGCAGTCCCTGCTTATGATGGGCTCCCCAGGAAGCCCACTGCCTCCTCCCTGGCTGCAGCCTCCGGGGTTCAGCCTCCTGT
CTCGCCAGAAGACTCCTAGGCCCTTGGGGTGGCGCGCCTGCCTTTTCTAGTTTTATACAAAGACAGCCACTTTTAGCTACTGCTAATGAG
ACTTGAGTCTATTTTTGTACAAAAGAGAAGCAAAATCTTTTTTCTAAACCTGTGCCTCCCTCTCCTCGGACACCCAGGGTCTAGCCGCTG
CCCTGGGTCCTGCCTGCAGTATTACAGAGGTCGTCGAAAGGTGCAGCTGCGTTCTGAGGGCGTGGGGAATGGGCAGGTGGCCTCTGCTGG
TCTCTGGCTCTACGTTTAGGCACCCCTTTCCCCAGCCTCTCCTCCTTGGGCAGGGTCTCTGCTCCAGCAAGCAAACAGGGTGGCCCAGGT
GGCTATTTTGAGAACTCCAGCTGGTGCCCCCAGACAGCTGCTCAGAGCCAAGGGGGCAGAGGGCTTTCAGCGCCCCCAGGCCTGCCCTGC
TATTTCAGGCCCTCAGCTGTCGGGGGCCACTGTGTTTCTGTGCTCCAAGTTGAGACTCGGCCGCAGCGGCGTCAGACTTTTCTTTGCGAT
GTCCTCGGTTTCCCATTTGTTGCTGCTGCTGCTCATTCCACACTGTTGAGACCTTGTGGTCTCGATGCTGCTGGCCTCCCTCCGTCCCTC
TGTCCACTTGTGGGTCCTGGGGTCGTCTTAGCAGAGCCACCGCCAAGGTTTGCACTCAGGGAGGGGCTGATGGAGGGCTGGGCGCCATGG
GGTCAGGGAGGCCCCAGGGACCCATGGGCAGAGCTGGGGAGCCAGGAGGATGGGTCTGCCTGCTCTGGGGGTGCAGGCTCTGCAGACACC
CCAATTGCTGCTCTGTTGCTGTGCCTAGTCTAGTGTCCCCCAAAGCATCGGGGGGCCACGCAAGTGTGGGTGTGTGAGTGTGCGTATGTG
GGGACCCCCCAGGGCATGGTGGGGTCTGAGGCGTGTGTTCCCATTTAGGGCTGAATGAAGCCATGACTTGGAAAGGTGGTGGGGGGTGGA
TGGCGGCTGTGACTCAGGGCCCAGGGATCACATGGGGGTCACTGCTGCCATCAGCAGTCAGGCAGGGAGAACAGAAATGCAAAAATACAG
ATGTCTATTTTTCTAAACTGGGGGGTGGAGGGGTGCCTCCTGACAGCTTCCAAAGAGCTGACTGTGGAGGGCCCACAGTGTATCCCACCC
CTGCCCGAGAGTCTCTCTCCTTTGGGACCCCCGGGTTCCCAGAGCTCCGAGGAAACTGATCCTTCATGTTTCAATAGCTGTTGTTGTTTT
TCTCTTTGGGCCGGGCCGGGCCGGGGAAGGGCCGAGCAGGCTCCAGGAGGCCTCCAGAGTCAGCTGGACCTTGCTGTGTCGCCCGCAGGC
AGCCCTGCAGACACCGGTGAGGTGGGATGATTTCAGGAGGTCCCAGCCCGGGACTGCCCGCCCCTCTGCCCTGGGAACCAGTCCAAGGGG
CTGTCAGTTGAATTTGCCTTTTTGTTGTTGTTGTTGTTTTTGTTGTTTATTTGTTCTCCTTTTAAGGAATTATGAAGCTAAGAAAAGTTT
TGTGTTTTGGGGGTTGGTGGACAAAGTTCTAGCTGATTAAATATGGTCTAACTTATTGATACTATTTTTTTTTCTTTTAATGTTGTACTG
TGGAGAAAAACTATTTTGAGCCATGGGGTTGGTGTTTACAAGAACTTTCCACTTTTGCCAAAATGTTACAATTGAAAGGCATCTATCTGC
GTCTTCAGTTTCCTGATATTTTCTTAAAAGATCTAGTGTCCTTTTTGTACACTAAACAGGTGAATGCTGACTTTTTTCATTCTCCAATAA

>102184_102184_1_ZNF480-ELL_ZNF480_chr19_52819215_ENST00000335090_ELL_chr19_18572662_ENST00000262809_length(amino acids)=502AA_BP=37
MNINSMLEQRREPWSGESEVKIAKNSDGRECIKGVNTGKKVQFRKPAPGATDAVPSRKRATPINLASAIRKSGASAVSGGSGVSQRPFRD
RVLHLLALRPYRKAELLLRLQKDGLTQADKDALDGLLQQVANMSAKDGTCTLQDCMYKDVQKDWPGYSEGDQQLLKRVLVRKLCQPQSTG
SLLGDPAASSPPGERGRSASPPQKRLQPPDFIDPLANKKPRISHFTQRAQPAVNGKLGVPNGREALLPTPGPPASTDTLSSSTHLPPRLE
PPRAHDPLADVSNDLGHSGRDCEHGEAAAPAPTVRLGLPLLTDCAQPSRPHGSPSRSKPKKKSKKHKDKERAAEDKPRAQLPDCAPATHA
TPGAPADTPGLNGTCSVSSVPTSTSETPDYLLKYAAISSSEQRQSYKNDFNAEYSEYRDLHARIERITRRFTQLDAQLRQLSQGSEEYET

--------------------------------------------------------------
>102184_102184_2_ZNF480-ELL_ZNF480_chr19_52819215_ENST00000335090_ELL_chr19_18572662_ENST00000596124_length(transcript)=1618nt_BP=220nt
GATTGACTTCTAAAGAGTCATGCTGTGTGATGAAAAAGCCCAGAAGAGAAGGAAGAGGAAAGCAAAGGAGTCAGGGATGGCTCTTCCTCA
GGAATCTCTCTTCCTGACCTGAATATTAACTCCATGTTGGAGCAAAGGAGGGAGCCCTGGTCTGGTGAGAGTGAAGTGAAAATAGCAAAA
AATTCAGATGGGAGGGAGTGCATCAAAGGTGTGAACACAGGCAAGAAGGTTCAGTTTCGGAAACCAGCCCCAGGTGCAACAGACGCGGTG
CCCTCCCGGAAGCGGGCAACCCCCATCAACTTGGCGAGTGCCATCAGGAAGAGTGGTGCCAGTGCCGTGAGTGGGGGCAGCGGGGTGTCC
CAGAGGCCCTTCCGTGACCGAGTGCTGCACCTCCTGGCACTACGGCCCTACCGCAAGGCTGAGCTGCTGCTGCGACTGCAGAAGGACGGC
CTGACGCAGGCGGACAAGGACGCGCTGGATGGCCTCCTCCAGCAGGTGGCCAACATGAGTGCTAAGGACGGCACGTGTACACTGCAGGAC
TGCATGTACAAGGATGTGCAGAAGGACTGGCCTGGCTACTCGGAGGGGGACCAGCAGCTGCTGAAGCGGGTGCTCGTCCGGAAGCTGTGC
CAGCCACAGAGCACTGGCAGCCTCCTTGGAGACCCTGCTGCCTCCAGCCCCCCAGGCGAGCGTGGGCGCTCGGCCTCGCCCCCACAGAAG
CGGCTGCAGCCTCCTGATTTCATCGACCCCCTAGCCAACAAGAAACCCCGGATATCGCACTTCACTCAGAGAGCTCAGCCTGCCGTCAAC
GGGAAGCTGGGCGTGCCCAATGGCCGTGAGGCCTTGCTGCCCACCCCGGGCCCACCAGCCAGCACGGACACCCTCAGCTCCAGCACTCAC
CTGCCCCCGCGGCTGGAGCCCCCGAGGGCCCACGACCCCCTGGCCGATGTCAGCAATGACCTGGGCCACAGCGGCCGAGACTGTGAGCAC
GGAGAGGCGGCTGCCCCAGCCCCCACTGTGCGCCTCGGCCTGCCCCTGCTGACGGACTGTGCCCAGCCCAGCAGGCCACACGGCAGCCCC
TCGCGCAGCAAGCCCAAGAAGAAGTCCAAGAAGCACAAAGACAAGGAGAGGGCGGCTGAGGACAAGCCCCGGGCCCAGCTTCCAGACTGT
GCACCTGCCACCCATGCCACCCCCGGAGCCCCAGCAGACACCCCAGGTTTAAACGGAACCTGCAGCGTTTCCAGTGTTCCCACGTCCACG
TCGGAGACGCCTGACTACTTGCTGAAGTACGCAGCCATCTCCTCTTCGGAGCAGCGCCAGAGCTACAAGAACGACTTCAATGCCGAGTAC
AGCGAGTACCGCGACCTGCACGCCCGCATTGAGCGCATCACGCGGCGGTTCACCCAGCTCGACGCCCAGCTCCGGCAGCTCTCCCAGGGC
TCCGAGGAGTATGAGACTACTCGAGGGCAGATTTTGCAGGAATATCGAAAAATCAAAAAGACCAACACCAACTACAGCCAGGAGAAGCAC

>102184_102184_2_ZNF480-ELL_ZNF480_chr19_52819215_ENST00000335090_ELL_chr19_18572662_ENST00000596124_length(amino acids)=502AA_BP=37
MNINSMLEQRREPWSGESEVKIAKNSDGRECIKGVNTGKKVQFRKPAPGATDAVPSRKRATPINLASAIRKSGASAVSGGSGVSQRPFRD
RVLHLLALRPYRKAELLLRLQKDGLTQADKDALDGLLQQVANMSAKDGTCTLQDCMYKDVQKDWPGYSEGDQQLLKRVLVRKLCQPQSTG
SLLGDPAASSPPGERGRSASPPQKRLQPPDFIDPLANKKPRISHFTQRAQPAVNGKLGVPNGREALLPTPGPPASTDTLSSSTHLPPRLE
PPRAHDPLADVSNDLGHSGRDCEHGEAAAPAPTVRLGLPLLTDCAQPSRPHGSPSRSKPKKKSKKHKDKERAAEDKPRAQLPDCAPATHA
TPGAPADTPGLNGTCSVSSVPTSTSETPDYLLKYAAISSSEQRQSYKNDFNAEYSEYRDLHARIERITRRFTQLDAQLRQLSQGSEEYET

--------------------------------------------------------------
>102184_102184_3_ZNF480-ELL_ZNF480_chr19_52819215_ENST00000595962_ELL_chr19_18572662_ENST00000262809_length(transcript)=3880nt_BP=394nt
ACAAACCCGGAAGCGGATCGCGTGGAGTGAAGGTCACGCCGCGGCGCGATTGACTTCTAAAGAGTCATGCTGTGTGATGAAAAAGCCCAG
AAGAGAAGGAAGAGGAAAGCAAAGGAGTCAGGGATGGCTCTTCCTCAGGGACACTTAACATTCAGGGACGTGGCCATAGAATTCTCTCAG
GCGGAGTGGAAATGCCTGGACCCTGCACAGAGGGCTTTATACAAGGATGTGATGTTGGAGAACTACAGGAACCTGGTCTCCCTGGGAATC
TCTCTTCCTGACCTGAATATTAACTCCATGTTGGAGCAAAGGAGGGAGCCCTGGTCTGGTGAGAGTGAAGTGAAAATAGCAAAAAATTCA
GATGGGAGGGAGTGCATCAAAGGTGTGAACACAGGCAAGAAGGTTCAGTTTCGGAAACCAGCCCCAGGTGCAACAGACGCGGTGCCCTCC
CGGAAGCGGGCAACCCCCATCAACTTGGCGAGTGCCATCAGGAAGAGTGGTGCCAGTGCCGTGAGTGGGGGCAGCGGGGTGTCCCAGAGG
CCCTTCCGTGACCGAGTGCTGCACCTCCTGGCACTACGGCCCTACCGCAAGGCTGAGCTGCTGCTGCGACTGCAGAAGGACGGCCTGACG
CAGGCGGACAAGGACGCGCTGGATGGCCTCCTCCAGCAGGTGGCCAACATGAGTGCTAAGGACGGCACGTGTACACTGCAGGACTGCATG
TACAAGGATGTGCAGAAGGACTGGCCTGGCTACTCGGAGGGGGACCAGCAGCTGCTGAAGCGGGTGCTCGTCCGGAAGCTGTGCCAGCCA
CAGAGCACTGGCAGCCTCCTTGGAGACCCTGCTGCCTCCAGCCCCCCAGGCGAGCGTGGGCGCTCGGCCTCGCCCCCACAGAAGCGGCTG
CAGCCTCCTGATTTCATCGACCCCCTAGCCAACAAGAAACCCCGGATATCGCACTTCACTCAGAGAGCTCAGCCTGCCGTCAACGGGAAG
CTGGGCGTGCCCAATGGCCGTGAGGCCTTGCTGCCCACCCCGGGCCCACCAGCCAGCACGGACACCCTCAGCTCCAGCACTCACCTGCCC
CCGCGGCTGGAGCCCCCGAGGGCCCACGACCCCCTGGCCGATGTCAGCAATGACCTGGGCCACAGCGGCCGAGACTGTGAGCACGGAGAG
GCGGCTGCCCCAGCCCCCACTGTGCGCCTCGGCCTGCCCCTGCTGACGGACTGTGCCCAGCCCAGCAGGCCACACGGCAGCCCCTCGCGC
AGCAAGCCCAAGAAGAAGTCCAAGAAGCACAAAGACAAGGAGAGGGCGGCTGAGGACAAGCCCCGGGCCCAGCTTCCAGACTGTGCACCT
GCCACCCATGCCACCCCCGGAGCCCCAGCAGACACCCCAGGTTTAAACGGAACCTGCAGCGTTTCCAGTGTTCCCACGTCCACGTCGGAG
ACGCCTGACTACTTGCTGAAGTACGCAGCCATCTCCTCTTCGGAGCAGCGCCAGAGCTACAAGAACGACTTCAATGCCGAGTACAGCGAG
TACCGCGACCTGCACGCCCGCATTGAGCGCATCACGCGGCGGTTCACCCAGCTCGACGCCCAGCTCCGGCAGCTCTCCCAGGGCTCCGAG
GAGTATGAGACTACTCGAGGGCAGATTTTGCAGGAATATCGAAAAATCAAAAAGACCAACACCAACTACAGCCAGGAGAAGCACCGCTGC
GAGTACCTGCACAGCAAGCTGGCCCACATCAAGAGGCTCATCGCCGAGTACGACCAGCGGCAGCTGCAGGCTTGGCCCTAGCCGCCCTCC
CCGATGGCGGGGATCTGGGAGGGTCGGGGGAGCAAAAGGCGGTGAGAGAGGATTTATTTAAAAAAATAAACCCGAGGAAGATGCTCATCT
GAGCCAGCACCGCCGGCTTTCAGGGCAGCCCCTGCAGACGTCTGGCCCTGGCGGGTGGCTGCAAGCCCACCTCGGCCCTCCCTGCGCTTC
CTGAGCAGTCCCTGCTTATGATGGGCTCCCCAGGAAGCCCACTGCCTCCTCCCTGGCTGCAGCCTCCGGGGTTCAGCCTCCTGTCTCGCC
AGAAGACTCCTAGGCCCTTGGGGTGGCGCGCCTGCCTTTTCTAGTTTTATACAAAGACAGCCACTTTTAGCTACTGCTAATGAGACTTGA
GTCTATTTTTGTACAAAAGAGAAGCAAAATCTTTTTTCTAAACCTGTGCCTCCCTCTCCTCGGACACCCAGGGTCTAGCCGCTGCCCTGG
GTCCTGCCTGCAGTATTACAGAGGTCGTCGAAAGGTGCAGCTGCGTTCTGAGGGCGTGGGGAATGGGCAGGTGGCCTCTGCTGGTCTCTG
GCTCTACGTTTAGGCACCCCTTTCCCCAGCCTCTCCTCCTTGGGCAGGGTCTCTGCTCCAGCAAGCAAACAGGGTGGCCCAGGTGGCTAT
TTTGAGAACTCCAGCTGGTGCCCCCAGACAGCTGCTCAGAGCCAAGGGGGCAGAGGGCTTTCAGCGCCCCCAGGCCTGCCCTGCTATTTC
AGGCCCTCAGCTGTCGGGGGCCACTGTGTTTCTGTGCTCCAAGTTGAGACTCGGCCGCAGCGGCGTCAGACTTTTCTTTGCGATGTCCTC
GGTTTCCCATTTGTTGCTGCTGCTGCTCATTCCACACTGTTGAGACCTTGTGGTCTCGATGCTGCTGGCCTCCCTCCGTCCCTCTGTCCA
CTTGTGGGTCCTGGGGTCGTCTTAGCAGAGCCACCGCCAAGGTTTGCACTCAGGGAGGGGCTGATGGAGGGCTGGGCGCCATGGGGTCAG
GGAGGCCCCAGGGACCCATGGGCAGAGCTGGGGAGCCAGGAGGATGGGTCTGCCTGCTCTGGGGGTGCAGGCTCTGCAGACACCCCAATT
GCTGCTCTGTTGCTGTGCCTAGTCTAGTGTCCCCCAAAGCATCGGGGGGCCACGCAAGTGTGGGTGTGTGAGTGTGCGTATGTGGGGACC
CCCCAGGGCATGGTGGGGTCTGAGGCGTGTGTTCCCATTTAGGGCTGAATGAAGCCATGACTTGGAAAGGTGGTGGGGGGTGGATGGCGG
CTGTGACTCAGGGCCCAGGGATCACATGGGGGTCACTGCTGCCATCAGCAGTCAGGCAGGGAGAACAGAAATGCAAAAATACAGATGTCT
ATTTTTCTAAACTGGGGGGTGGAGGGGTGCCTCCTGACAGCTTCCAAAGAGCTGACTGTGGAGGGCCCACAGTGTATCCCACCCCTGCCC
GAGAGTCTCTCTCCTTTGGGACCCCCGGGTTCCCAGAGCTCCGAGGAAACTGATCCTTCATGTTTCAATAGCTGTTGTTGTTTTTCTCTT
TGGGCCGGGCCGGGCCGGGGAAGGGCCGAGCAGGCTCCAGGAGGCCTCCAGAGTCAGCTGGACCTTGCTGTGTCGCCCGCAGGCAGCCCT
GCAGACACCGGTGAGGTGGGATGATTTCAGGAGGTCCCAGCCCGGGACTGCCCGCCCCTCTGCCCTGGGAACCAGTCCAAGGGGCTGTCA
GTTGAATTTGCCTTTTTGTTGTTGTTGTTGTTTTTGTTGTTTATTTGTTCTCCTTTTAAGGAATTATGAAGCTAAGAAAAGTTTTGTGTT
TTGGGGGTTGGTGGACAAAGTTCTAGCTGATTAAATATGGTCTAACTTATTGATACTATTTTTTTTTCTTTTAATGTTGTACTGTGGAGA
AAAACTATTTTGAGCCATGGGGTTGGTGTTTACAAGAACTTTCCACTTTTGCCAAAATGTTACAATTGAAAGGCATCTATCTGCGTCTTC
AGTTTCCTGATATTTTCTTAAAAGATCTAGTGTCCTTTTTGTACACTAAACAGGTGAATGCTGACTTTTTTCATTCTCCAATAAATTTCA

>102184_102184_3_ZNF480-ELL_ZNF480_chr19_52819215_ENST00000595962_ELL_chr19_18572662_ENST00000262809_length(amino acids)=574AA_BP=109
MLCDEKAQKRRKRKAKESGMALPQGHLTFRDVAIEFSQAEWKCLDPAQRALYKDVMLENYRNLVSLGISLPDLNINSMLEQRREPWSGES
EVKIAKNSDGRECIKGVNTGKKVQFRKPAPGATDAVPSRKRATPINLASAIRKSGASAVSGGSGVSQRPFRDRVLHLLALRPYRKAELLL
RLQKDGLTQADKDALDGLLQQVANMSAKDGTCTLQDCMYKDVQKDWPGYSEGDQQLLKRVLVRKLCQPQSTGSLLGDPAASSPPGERGRS
ASPPQKRLQPPDFIDPLANKKPRISHFTQRAQPAVNGKLGVPNGREALLPTPGPPASTDTLSSSTHLPPRLEPPRAHDPLADVSNDLGHS
GRDCEHGEAAAPAPTVRLGLPLLTDCAQPSRPHGSPSRSKPKKKSKKHKDKERAAEDKPRAQLPDCAPATHATPGAPADTPGLNGTCSVS
SVPTSTSETPDYLLKYAAISSSEQRQSYKNDFNAEYSEYRDLHARIERITRRFTQLDAQLRQLSQGSEEYETTRGQILQEYRKIKKTNTN

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>102184_102184_4_ZNF480-ELL_ZNF480_chr19_52819215_ENST00000595962_ELL_chr19_18572662_ENST00000596124_length(transcript)=1792nt_BP=394nt
ACAAACCCGGAAGCGGATCGCGTGGAGTGAAGGTCACGCCGCGGCGCGATTGACTTCTAAAGAGTCATGCTGTGTGATGAAAAAGCCCAG
AAGAGAAGGAAGAGGAAAGCAAAGGAGTCAGGGATGGCTCTTCCTCAGGGACACTTAACATTCAGGGACGTGGCCATAGAATTCTCTCAG
GCGGAGTGGAAATGCCTGGACCCTGCACAGAGGGCTTTATACAAGGATGTGATGTTGGAGAACTACAGGAACCTGGTCTCCCTGGGAATC
TCTCTTCCTGACCTGAATATTAACTCCATGTTGGAGCAAAGGAGGGAGCCCTGGTCTGGTGAGAGTGAAGTGAAAATAGCAAAAAATTCA
GATGGGAGGGAGTGCATCAAAGGTGTGAACACAGGCAAGAAGGTTCAGTTTCGGAAACCAGCCCCAGGTGCAACAGACGCGGTGCCCTCC
CGGAAGCGGGCAACCCCCATCAACTTGGCGAGTGCCATCAGGAAGAGTGGTGCCAGTGCCGTGAGTGGGGGCAGCGGGGTGTCCCAGAGG
CCCTTCCGTGACCGAGTGCTGCACCTCCTGGCACTACGGCCCTACCGCAAGGCTGAGCTGCTGCTGCGACTGCAGAAGGACGGCCTGACG
CAGGCGGACAAGGACGCGCTGGATGGCCTCCTCCAGCAGGTGGCCAACATGAGTGCTAAGGACGGCACGTGTACACTGCAGGACTGCATG
TACAAGGATGTGCAGAAGGACTGGCCTGGCTACTCGGAGGGGGACCAGCAGCTGCTGAAGCGGGTGCTCGTCCGGAAGCTGTGCCAGCCA
CAGAGCACTGGCAGCCTCCTTGGAGACCCTGCTGCCTCCAGCCCCCCAGGCGAGCGTGGGCGCTCGGCCTCGCCCCCACAGAAGCGGCTG
CAGCCTCCTGATTTCATCGACCCCCTAGCCAACAAGAAACCCCGGATATCGCACTTCACTCAGAGAGCTCAGCCTGCCGTCAACGGGAAG
CTGGGCGTGCCCAATGGCCGTGAGGCCTTGCTGCCCACCCCGGGCCCACCAGCCAGCACGGACACCCTCAGCTCCAGCACTCACCTGCCC
CCGCGGCTGGAGCCCCCGAGGGCCCACGACCCCCTGGCCGATGTCAGCAATGACCTGGGCCACAGCGGCCGAGACTGTGAGCACGGAGAG
GCGGCTGCCCCAGCCCCCACTGTGCGCCTCGGCCTGCCCCTGCTGACGGACTGTGCCCAGCCCAGCAGGCCACACGGCAGCCCCTCGCGC
AGCAAGCCCAAGAAGAAGTCCAAGAAGCACAAAGACAAGGAGAGGGCGGCTGAGGACAAGCCCCGGGCCCAGCTTCCAGACTGTGCACCT
GCCACCCATGCCACCCCCGGAGCCCCAGCAGACACCCCAGGTTTAAACGGAACCTGCAGCGTTTCCAGTGTTCCCACGTCCACGTCGGAG
ACGCCTGACTACTTGCTGAAGTACGCAGCCATCTCCTCTTCGGAGCAGCGCCAGAGCTACAAGAACGACTTCAATGCCGAGTACAGCGAG
TACCGCGACCTGCACGCCCGCATTGAGCGCATCACGCGGCGGTTCACCCAGCTCGACGCCCAGCTCCGGCAGCTCTCCCAGGGCTCCGAG
GAGTATGAGACTACTCGAGGGCAGATTTTGCAGGAATATCGAAAAATCAAAAAGACCAACACCAACTACAGCCAGGAGAAGCACCGCTGC

>102184_102184_4_ZNF480-ELL_ZNF480_chr19_52819215_ENST00000595962_ELL_chr19_18572662_ENST00000596124_length(amino acids)=574AA_BP=109
MLCDEKAQKRRKRKAKESGMALPQGHLTFRDVAIEFSQAEWKCLDPAQRALYKDVMLENYRNLVSLGISLPDLNINSMLEQRREPWSGES
EVKIAKNSDGRECIKGVNTGKKVQFRKPAPGATDAVPSRKRATPINLASAIRKSGASAVSGGSGVSQRPFRDRVLHLLALRPYRKAELLL
RLQKDGLTQADKDALDGLLQQVANMSAKDGTCTLQDCMYKDVQKDWPGYSEGDQQLLKRVLVRKLCQPQSTGSLLGDPAASSPPGERGRS
ASPPQKRLQPPDFIDPLANKKPRISHFTQRAQPAVNGKLGVPNGREALLPTPGPPASTDTLSSSTHLPPRLEPPRAHDPLADVSNDLGHS
GRDCEHGEAAAPAPTVRLGLPLLTDCAQPSRPHGSPSRSKPKKKSKKHKDKERAAEDKPRAQLPDCAPATHATPGAPADTPGLNGTCSVS
SVPTSTSETPDYLLKYAAISSSEQRQSYKNDFNAEYSEYRDLHARIERITRRFTQLDAQLRQLSQGSEEYETTRGQILQEYRKIKKTNTN

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Fusion Gene PPI Analysis for ZNF480-ELL

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ZNF480-ELL

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ZNF480-ELL

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source