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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF493-TMBIM4 (FusionGDB2 ID:102200)

Fusion Gene Summary for ZNF493-TMBIM4

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF493-TMBIM4
Fusion gene ID: 102200
HgeneTgene
Gene symbol

ZNF493

TMBIM4

Gene ID

284443

51643

Gene namezinc finger protein 493transmembrane BAX inhibitor motif containing 4
Synonyms-CGI-119|GAAP|LFG4|S1R|ZPRO
Cytomap

19p12

12q14.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 493protein lifeguard 4Golgi anti-apoptotic proteinZ-proteintransmembrane BAX inhibitor motif-containing protein 4
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000594390, ENST00000339914, 
ENST00000392288, ENST00000596302, 
ENST00000599461, ENST00000355504, 
ENST00000358230, ENST00000539652, 
ENST00000556010, ENST00000286424, 
ENST00000398033, ENST00000544599, 
ENST00000535812, ENST00000542724, 
Fusion gene scores* DoF score4 X 3 X 4=489 X 5 X 6=270
# samples 49
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/270*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF493 [Title/Abstract] AND TMBIM4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF493(21596451)-TMBIM4(66547228), # samples:1
ZNF493(21580069)-TMBIM4(66547228), # samples:1
Anticipated loss of major functional domain due to fusion event.ZNF493-TMBIM4 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTMBIM4

GO:0050848

regulation of calcium-mediated signaling

19553469


check buttonFusion gene breakpoints across ZNF493 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TMBIM4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A48N-01AZNF493chr19

21580069

-TMBIM4chr12

66547228

-
ChimerDB4SARCTCGA-DX-A48N-01AZNF493chr19

21596451

+TMBIM4chr12

66547228

-


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Fusion Gene ORF analysis for ZNF493-TMBIM4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000594390ENST00000358230ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
3UTR-3CDSENST00000594390ENST00000539652ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
3UTR-3CDSENST00000594390ENST00000556010ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
3UTR-5UTRENST00000594390ENST00000286424ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
3UTR-5UTRENST00000594390ENST00000398033ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
3UTR-5UTRENST00000594390ENST00000544599ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
3UTR-intronENST00000594390ENST00000535812ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
3UTR-intronENST00000594390ENST00000542724ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
5CDS-5UTRENST00000339914ENST00000286424ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
5CDS-5UTRENST00000339914ENST00000398033ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
5CDS-5UTRENST00000339914ENST00000544599ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
5CDS-5UTRENST00000392288ENST00000286424ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
5CDS-5UTRENST00000392288ENST00000398033ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
5CDS-5UTRENST00000392288ENST00000544599ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
5CDS-5UTRENST00000594390ENST00000286424ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
5CDS-5UTRENST00000594390ENST00000398033ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
5CDS-5UTRENST00000594390ENST00000544599ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
5CDS-5UTRENST00000596302ENST00000286424ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
5CDS-5UTRENST00000596302ENST00000398033ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
5CDS-5UTRENST00000596302ENST00000544599ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
5CDS-5UTRENST00000599461ENST00000286424ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
5CDS-5UTRENST00000599461ENST00000398033ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
5CDS-5UTRENST00000599461ENST00000544599ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
5CDS-intronENST00000339914ENST00000535812ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
5CDS-intronENST00000339914ENST00000542724ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
5CDS-intronENST00000392288ENST00000535812ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
5CDS-intronENST00000392288ENST00000542724ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
5CDS-intronENST00000594390ENST00000535812ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
5CDS-intronENST00000594390ENST00000542724ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
5CDS-intronENST00000596302ENST00000535812ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
5CDS-intronENST00000596302ENST00000542724ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
5CDS-intronENST00000599461ENST00000535812ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
5CDS-intronENST00000599461ENST00000542724ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
5UTR-3CDSENST00000355504ENST00000358230ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
5UTR-3CDSENST00000355504ENST00000539652ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
5UTR-3CDSENST00000355504ENST00000556010ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
5UTR-5UTRENST00000355504ENST00000286424ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
5UTR-5UTRENST00000355504ENST00000398033ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
5UTR-5UTRENST00000355504ENST00000544599ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
5UTR-intronENST00000355504ENST00000535812ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
5UTR-intronENST00000355504ENST00000542724ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
Frame-shiftENST00000339914ENST00000358230ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
Frame-shiftENST00000392288ENST00000358230ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
Frame-shiftENST00000594390ENST00000358230ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
Frame-shiftENST00000596302ENST00000358230ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
Frame-shiftENST00000599461ENST00000358230ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
Frame-shiftENST00000599461ENST00000539652ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
Frame-shiftENST00000599461ENST00000556010ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
In-frameENST00000339914ENST00000539652ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
In-frameENST00000339914ENST00000556010ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
In-frameENST00000392288ENST00000539652ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
In-frameENST00000392288ENST00000556010ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
In-frameENST00000594390ENST00000539652ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
In-frameENST00000594390ENST00000556010ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
In-frameENST00000596302ENST00000539652ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
In-frameENST00000596302ENST00000556010ZNF493chr19

21580069

-TMBIM4chr12

66547228

-
intron-3CDSENST00000339914ENST00000358230ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-3CDSENST00000339914ENST00000539652ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-3CDSENST00000339914ENST00000556010ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-3CDSENST00000355504ENST00000358230ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-3CDSENST00000355504ENST00000539652ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-3CDSENST00000355504ENST00000556010ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-3CDSENST00000392288ENST00000358230ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-3CDSENST00000392288ENST00000539652ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-3CDSENST00000392288ENST00000556010ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-3CDSENST00000596302ENST00000358230ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-3CDSENST00000596302ENST00000539652ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-3CDSENST00000596302ENST00000556010ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-3CDSENST00000599461ENST00000358230ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-3CDSENST00000599461ENST00000539652ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-3CDSENST00000599461ENST00000556010ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-5UTRENST00000339914ENST00000286424ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-5UTRENST00000339914ENST00000398033ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-5UTRENST00000339914ENST00000544599ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-5UTRENST00000355504ENST00000286424ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-5UTRENST00000355504ENST00000398033ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-5UTRENST00000355504ENST00000544599ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-5UTRENST00000392288ENST00000286424ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-5UTRENST00000392288ENST00000398033ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-5UTRENST00000392288ENST00000544599ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-5UTRENST00000596302ENST00000286424ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-5UTRENST00000596302ENST00000398033ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-5UTRENST00000596302ENST00000544599ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-5UTRENST00000599461ENST00000286424ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-5UTRENST00000599461ENST00000398033ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-5UTRENST00000599461ENST00000544599ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-intronENST00000339914ENST00000535812ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-intronENST00000339914ENST00000542724ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-intronENST00000355504ENST00000535812ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-intronENST00000355504ENST00000542724ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-intronENST00000392288ENST00000535812ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-intronENST00000392288ENST00000542724ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-intronENST00000596302ENST00000535812ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-intronENST00000596302ENST00000542724ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-intronENST00000599461ENST00000535812ZNF493chr19

21596451

+TMBIM4chr12

66547228

-
intron-intronENST00000599461ENST00000542724ZNF493chr19

21596451

+TMBIM4chr12

66547228

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000596302ZNF493chr1921580069-ENST00000539652TMBIM4chr1266547228-1002149154558134
ENST00000596302ZNF493chr1921580069-ENST00000556010TMBIM4chr1266547228-990149154558134
ENST00000392288ZNF493chr1921580069-ENST00000539652TMBIM4chr1266547228-992139144548134
ENST00000392288ZNF493chr1921580069-ENST00000556010TMBIM4chr1266547228-980139144548134
ENST00000594390ZNF493chr1921580069-ENST00000539652TMBIM4chr1266547228-988135140544134
ENST00000594390ZNF493chr1921580069-ENST00000556010TMBIM4chr1266547228-976135140544134
ENST00000339914ZNF493chr1921580069-ENST00000539652TMBIM4chr1266547228-965112117521134
ENST00000339914ZNF493chr1921580069-ENST00000556010TMBIM4chr1266547228-953112117521134

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000596302ENST00000539652ZNF493chr1921580069-TMBIM4chr1266547228-0.65223270.3477673
ENST00000596302ENST00000556010ZNF493chr1921580069-TMBIM4chr1266547228-0.64257290.35742706
ENST00000392288ENST00000539652ZNF493chr1921580069-TMBIM4chr1266547228-0.633707760.36629227
ENST00000392288ENST00000556010ZNF493chr1921580069-TMBIM4chr1266547228-0.63181160.36818838
ENST00000594390ENST00000539652ZNF493chr1921580069-TMBIM4chr1266547228-0.614516560.3854835
ENST00000594390ENST00000556010ZNF493chr1921580069-TMBIM4chr1266547228-0.61282840.3871716
ENST00000339914ENST00000539652ZNF493chr1921580069-TMBIM4chr1266547228-0.75545970.24454033
ENST00000339914ENST00000556010ZNF493chr1921580069-TMBIM4chr1266547228-0.74748330.25251672

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Fusion Genomic Features for ZNF493-TMBIM4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF493-TMBIM4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:21596451/chr12:66547228)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTMBIM4chr19:21580069chr12:66547228ENST0000035823007209_22932239.0IntramembraneHelical
TgeneTMBIM4chr19:21580069chr12:66547228ENST0000035823007119_12032239.0Topological domainLumenal
TgeneTMBIM4chr19:21580069chr12:66547228ENST0000035823007142_15132239.0Topological domainCytoplasmic
TgeneTMBIM4chr19:21580069chr12:66547228ENST0000035823007173_17532239.0Topological domainLumenal
TgeneTMBIM4chr19:21580069chr12:66547228ENST0000035823007197_20832239.0Topological domainCytoplasmic
TgeneTMBIM4chr19:21580069chr12:66547228ENST0000035823007230_23832239.0Topological domainCytoplasmic
TgeneTMBIM4chr19:21580069chr12:66547228ENST000003582300760_6832239.0Topological domainLumenal
TgeneTMBIM4chr19:21580069chr12:66547228ENST000003582300790_9732239.0Topological domainCytoplasmic
TgeneTMBIM4chr19:21580069chr12:66547228ENST0000035823007121_14132239.0TransmembraneHelical
TgeneTMBIM4chr19:21580069chr12:66547228ENST0000035823007152_17232239.0TransmembraneHelical
TgeneTMBIM4chr19:21580069chr12:66547228ENST0000035823007176_19632239.0TransmembraneHelical
TgeneTMBIM4chr19:21580069chr12:66547228ENST000003582300739_5932239.0TransmembraneHelical
TgeneTMBIM4chr19:21580069chr12:66547228ENST000003582300769_8932239.0TransmembraneHelical
TgeneTMBIM4chr19:21580069chr12:66547228ENST000003582300798_11832239.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914-14109_13110104.0Zinc fingerC2H2-type 4%3B degenerate
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914-14137_15910104.0Zinc fingerC2H2-type 5
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914-14165_18710104.0Zinc fingerC2H2-type 6%3B degenerate
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914-14193_21510104.0Zinc fingerC2H2-type 7%3B degenerate
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914-14221_24310104.0Zinc fingerC2H2-type 8%3B degenerate
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914-14249_27110104.0Zinc fingerC2H2-type 9
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914-1426_4810104.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914-14277_29910104.0Zinc fingerC2H2-type 10
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914-14305_32710104.0Zinc fingerC2H2-type 11
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914-14333_35510104.0Zinc fingerC2H2-type 12
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914-14361_38310104.0Zinc fingerC2H2-type 13
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914-14389_41110104.0Zinc fingerC2H2-type 14
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914-14417_43910104.0Zinc fingerC2H2-type 15
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914-14445_46710104.0Zinc fingerC2H2-type 16
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914-14473_49510104.0Zinc fingerC2H2-type 17
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914-14501_52310104.0Zinc fingerC2H2-type 18
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914-14529_55110104.0Zinc fingerC2H2-type 19
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914-1454_7610104.0Zinc fingerC2H2-type 2
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914-14557_57910104.0Zinc fingerC2H2-type 20
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914-14585_60710104.0Zinc fingerC2H2-type 21
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914-14613_63510104.0Zinc fingerC2H2-type 22
HgeneZNF493chr19:21580069chr12:66547228ENST00000339914-1482_10410104.0Zinc fingerC2H2-type 3
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504-12109_1310647.0Zinc fingerC2H2-type 4%3B degenerate
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504-12137_1590647.0Zinc fingerC2H2-type 5
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504-12165_1870647.0Zinc fingerC2H2-type 6%3B degenerate
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504-12193_2150647.0Zinc fingerC2H2-type 7%3B degenerate
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504-12221_2430647.0Zinc fingerC2H2-type 8%3B degenerate
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504-12249_2710647.0Zinc fingerC2H2-type 9
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504-1226_480647.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504-12277_2990647.0Zinc fingerC2H2-type 10
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504-12305_3270647.0Zinc fingerC2H2-type 11
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504-12333_3550647.0Zinc fingerC2H2-type 12
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504-12361_3830647.0Zinc fingerC2H2-type 13
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504-12389_4110647.0Zinc fingerC2H2-type 14
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504-12417_4390647.0Zinc fingerC2H2-type 15
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504-12445_4670647.0Zinc fingerC2H2-type 16
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504-12473_4950647.0Zinc fingerC2H2-type 17
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504-12501_5230647.0Zinc fingerC2H2-type 18
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504-12529_5510647.0Zinc fingerC2H2-type 19
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504-1254_760647.0Zinc fingerC2H2-type 2
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504-12557_5790647.0Zinc fingerC2H2-type 20
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504-12585_6070647.0Zinc fingerC2H2-type 21
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504-12613_6350647.0Zinc fingerC2H2-type 22
HgeneZNF493chr19:21580069chr12:66547228ENST00000355504-1282_1040647.0Zinc fingerC2H2-type 3
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288-14109_13110775.0Zinc fingerC2H2-type 4%3B degenerate
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288-14137_15910775.0Zinc fingerC2H2-type 5
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288-14165_18710775.0Zinc fingerC2H2-type 6%3B degenerate
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288-14193_21510775.0Zinc fingerC2H2-type 7%3B degenerate
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288-14221_24310775.0Zinc fingerC2H2-type 8%3B degenerate
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288-14249_27110775.0Zinc fingerC2H2-type 9
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288-1426_4810775.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288-14277_29910775.0Zinc fingerC2H2-type 10
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288-14305_32710775.0Zinc fingerC2H2-type 11
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288-14333_35510775.0Zinc fingerC2H2-type 12
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288-14361_38310775.0Zinc fingerC2H2-type 13
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288-14389_41110775.0Zinc fingerC2H2-type 14
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288-14417_43910775.0Zinc fingerC2H2-type 15
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288-14445_46710775.0Zinc fingerC2H2-type 16
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288-14473_49510775.0Zinc fingerC2H2-type 17
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288-14501_52310775.0Zinc fingerC2H2-type 18
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288-14529_55110775.0Zinc fingerC2H2-type 19
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288-1454_7610775.0Zinc fingerC2H2-type 2
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288-14557_57910775.0Zinc fingerC2H2-type 20
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288-14585_60710775.0Zinc fingerC2H2-type 21
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288-14613_63510775.0Zinc fingerC2H2-type 22
HgeneZNF493chr19:21580069chr12:66547228ENST00000392288-1482_10410775.0Zinc fingerC2H2-type 3
TgeneTMBIM4chr19:21580069chr12:66547228ENST00000358230071_3832239.0Topological domainCytoplasmic


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Fusion Gene Sequence for ZNF493-TMBIM4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>102200_102200_1_ZNF493-TMBIM4_ZNF493_chr19_21580069_ENST00000339914_TMBIM4_chr12_66547228_ENST00000539652_length(transcript)=965nt_BP=112nt
CTCCAGGTCTACCCTTCACTGCTCTGTGTCCTCAGCGTGTGTGGCTTCGTGACCTGAAGATACTGGGAAATCCATAGCTAAGATGCCAGG
ACCCCCTGAAAGCCTAGACATGCCTTTCTGAGAAAAGTCTACAGCATTCTTTCTCTGCAGGTTCTCTTAACTACAGTGACTTCAACAGTT
TTTTTATACTTTGAGTCTGTACGGACATTTGTACATGAGAGTCCTGCCTTAATTTTGCTGTTTGCCCTCGGATCTCTGGGTTTGATTTTT
GCGTTGATTTTAAACAGACATAAGTATCCCCTTAACCTGTACCTACTTTTTGGATTTACGCTGTTGGAAGCTCTGACTGTGGCAGTTGTT
GTTACTTTCTATGATGTATATATTATTCTGCAAGCTTTCATACTGACTACTACAGTATTTTTTGGTTTGACTGTGTATACTCTACAATCT
AAGAAGGATTTCAGCAAATTTGGAGCAGGCCGCTGCAGGAGCCCTTCTTTTCTGTGGATTCATCATCTATGACACACACTCACTGATGCA
TAAACTGTCACCTGAAGAGTACGTATTAGCTGCCATCAGCCTCTACTTGGATATCATCAATCTATTCCTGCACCTGTTACGGTTTCTGGA
AGCAGTTAATAAAAAGTAAAACATGGCTAAAAGCTTACGGAGTAAGTGGAAAAGAAAGATGCGTGCTGAAAAGAGAAAAAAGAATGCCCC
AAAGGAGGCCAGCAGGCTTAAAAGTATTCTCAAACTAGACGGTGATGTTTTAATGAAAGATGTTCAAGAGATAGCAACTGTGGTGGTACC
CAAACCCAAACATTGCCAAGAGAAAATGCAATGTGAGGTAAAAGATGAAAAAGATGACATGAAAATGGAGACTGATATTAAGAGAAACAA

>102200_102200_1_ZNF493-TMBIM4_ZNF493_chr19_21580069_ENST00000339914_TMBIM4_chr12_66547228_ENST00000539652_length(amino acids)=134AA_BP=
MRKVYSILSLQVLLTTVTSTVFLYFESVRTFVHESPALILLFALGSLGLIFALILNRHKYPLNLYLLFGFTLLEALTVAVVVTFYDVYII

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>102200_102200_2_ZNF493-TMBIM4_ZNF493_chr19_21580069_ENST00000339914_TMBIM4_chr12_66547228_ENST00000556010_length(transcript)=953nt_BP=112nt
CTCCAGGTCTACCCTTCACTGCTCTGTGTCCTCAGCGTGTGTGGCTTCGTGACCTGAAGATACTGGGAAATCCATAGCTAAGATGCCAGG
ACCCCCTGAAAGCCTAGACATGCCTTTCTGAGAAAAGTCTACAGCATTCTTTCTCTGCAGGTTCTCTTAACTACAGTGACTTCAACAGTT
TTTTTATACTTTGAGTCTGTACGGACATTTGTACATGAGAGTCCTGCCTTAATTTTGCTGTTTGCCCTCGGATCTCTGGGTTTGATTTTT
GCGTTGATTTTAAACAGACATAAGTATCCCCTTAACCTGTACCTACTTTTTGGATTTACGCTGTTGGAAGCTCTGACTGTGGCAGTTGTT
GTTACTTTCTATGATGTATATATTATTCTGCAAGCTTTCATACTGACTACTACAGTATTTTTTGGTTTGACTGTGTATACTCTACAATCT
AAGAAGGATTTCAGCAAATTTGGAGCAGGCCGCTGCAGGAGCCCTTCTTTTCTGTGGATTCATCATCTATGACACACACTCACTGATGCA
TAAACTGTCACCTGAAGAGTACGTATTAGCTGCCATCAGCCTCTACTTGGATATCATCAATCTATTCCTGCACCTGTTACGGTTTCTGGA
AGCAGTTAATAAAAAGTAAAACATGGCTAAAAGCTTACGGAGTAAGTGGAAAAGAAAGATGCGTGCTGAAAAGAGAAAAAAGAATGCCCC
AAAGGAGGCCAGCAGGCTTAAAAGTATTCTCAAACTAGACGGTGATGTTTTAATGAAAGATGTTCAAGAGATAGCAACTGTGGTGGTACC
CAAACCCAAACATTGCCAAGAGAAAATGCAATGTGAGGTAAAAGATGAAAAAGATGACATGAAAATGGAGACTGATATTAAGAGAAACAA

>102200_102200_2_ZNF493-TMBIM4_ZNF493_chr19_21580069_ENST00000339914_TMBIM4_chr12_66547228_ENST00000556010_length(amino acids)=134AA_BP=
MRKVYSILSLQVLLTTVTSTVFLYFESVRTFVHESPALILLFALGSLGLIFALILNRHKYPLNLYLLFGFTLLEALTVAVVVTFYDVYII

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>102200_102200_3_ZNF493-TMBIM4_ZNF493_chr19_21580069_ENST00000392288_TMBIM4_chr12_66547228_ENST00000539652_length(transcript)=992nt_BP=139nt
GGCCATTGTTTCTCTCTGCTGCCGGAGCTCCAGGTCTACCCTTCACTGCTCTGTGTCCTCAGCGTGTGTGGCTTCGTGACCTGAAGATAC
TGGGAAATCCATAGCTAAGATGCCAGGACCCCCTGAAAGCCTAGACATGCCTTTCTGAGAAAAGTCTACAGCATTCTTTCTCTGCAGGTT
CTCTTAACTACAGTGACTTCAACAGTTTTTTTATACTTTGAGTCTGTACGGACATTTGTACATGAGAGTCCTGCCTTAATTTTGCTGTTT
GCCCTCGGATCTCTGGGTTTGATTTTTGCGTTGATTTTAAACAGACATAAGTATCCCCTTAACCTGTACCTACTTTTTGGATTTACGCTG
TTGGAAGCTCTGACTGTGGCAGTTGTTGTTACTTTCTATGATGTATATATTATTCTGCAAGCTTTCATACTGACTACTACAGTATTTTTT
GGTTTGACTGTGTATACTCTACAATCTAAGAAGGATTTCAGCAAATTTGGAGCAGGCCGCTGCAGGAGCCCTTCTTTTCTGTGGATTCAT
CATCTATGACACACACTCACTGATGCATAAACTGTCACCTGAAGAGTACGTATTAGCTGCCATCAGCCTCTACTTGGATATCATCAATCT
ATTCCTGCACCTGTTACGGTTTCTGGAAGCAGTTAATAAAAAGTAAAACATGGCTAAAAGCTTACGGAGTAAGTGGAAAAGAAAGATGCG
TGCTGAAAAGAGAAAAAAGAATGCCCCAAAGGAGGCCAGCAGGCTTAAAAGTATTCTCAAACTAGACGGTGATGTTTTAATGAAAGATGT
TCAAGAGATAGCAACTGTGGTGGTACCCAAACCCAAACATTGCCAAGAGAAAATGCAATGTGAGGTAAAAGATGAAAAAGATGACATGAA
AATGGAGACTGATATTAAGAGAAACAAAAAGACTCTTCTAGACCAGCATGGACAGTACCCAATATGGATGAACCAAAGGCAAAGAAAAAG

>102200_102200_3_ZNF493-TMBIM4_ZNF493_chr19_21580069_ENST00000392288_TMBIM4_chr12_66547228_ENST00000539652_length(amino acids)=134AA_BP=
MRKVYSILSLQVLLTTVTSTVFLYFESVRTFVHESPALILLFALGSLGLIFALILNRHKYPLNLYLLFGFTLLEALTVAVVVTFYDVYII

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>102200_102200_4_ZNF493-TMBIM4_ZNF493_chr19_21580069_ENST00000392288_TMBIM4_chr12_66547228_ENST00000556010_length(transcript)=980nt_BP=139nt
GGCCATTGTTTCTCTCTGCTGCCGGAGCTCCAGGTCTACCCTTCACTGCTCTGTGTCCTCAGCGTGTGTGGCTTCGTGACCTGAAGATAC
TGGGAAATCCATAGCTAAGATGCCAGGACCCCCTGAAAGCCTAGACATGCCTTTCTGAGAAAAGTCTACAGCATTCTTTCTCTGCAGGTT
CTCTTAACTACAGTGACTTCAACAGTTTTTTTATACTTTGAGTCTGTACGGACATTTGTACATGAGAGTCCTGCCTTAATTTTGCTGTTT
GCCCTCGGATCTCTGGGTTTGATTTTTGCGTTGATTTTAAACAGACATAAGTATCCCCTTAACCTGTACCTACTTTTTGGATTTACGCTG
TTGGAAGCTCTGACTGTGGCAGTTGTTGTTACTTTCTATGATGTATATATTATTCTGCAAGCTTTCATACTGACTACTACAGTATTTTTT
GGTTTGACTGTGTATACTCTACAATCTAAGAAGGATTTCAGCAAATTTGGAGCAGGCCGCTGCAGGAGCCCTTCTTTTCTGTGGATTCAT
CATCTATGACACACACTCACTGATGCATAAACTGTCACCTGAAGAGTACGTATTAGCTGCCATCAGCCTCTACTTGGATATCATCAATCT
ATTCCTGCACCTGTTACGGTTTCTGGAAGCAGTTAATAAAAAGTAAAACATGGCTAAAAGCTTACGGAGTAAGTGGAAAAGAAAGATGCG
TGCTGAAAAGAGAAAAAAGAATGCCCCAAAGGAGGCCAGCAGGCTTAAAAGTATTCTCAAACTAGACGGTGATGTTTTAATGAAAGATGT
TCAAGAGATAGCAACTGTGGTGGTACCCAAACCCAAACATTGCCAAGAGAAAATGCAATGTGAGGTAAAAGATGAAAAAGATGACATGAA

>102200_102200_4_ZNF493-TMBIM4_ZNF493_chr19_21580069_ENST00000392288_TMBIM4_chr12_66547228_ENST00000556010_length(amino acids)=134AA_BP=
MRKVYSILSLQVLLTTVTSTVFLYFESVRTFVHESPALILLFALGSLGLIFALILNRHKYPLNLYLLFGFTLLEALTVAVVVTFYDVYII

--------------------------------------------------------------
>102200_102200_5_ZNF493-TMBIM4_ZNF493_chr19_21580069_ENST00000594390_TMBIM4_chr12_66547228_ENST00000539652_length(transcript)=988nt_BP=135nt
ATTGTTTCTCTCTGCTGCCGGAGCTCCAGGTCTACCCTTCACTGCTCTGTGTCCTCAGCGTGTGTGGCTTCGTGACCTGAAGATACTGGG
AAATCCATAGCTAAGATGCCAGGACCCCCTGAAAGCCTAGACATGCCTTTCTGAGAAAAGTCTACAGCATTCTTTCTCTGCAGGTTCTCT
TAACTACAGTGACTTCAACAGTTTTTTTATACTTTGAGTCTGTACGGACATTTGTACATGAGAGTCCTGCCTTAATTTTGCTGTTTGCCC
TCGGATCTCTGGGTTTGATTTTTGCGTTGATTTTAAACAGACATAAGTATCCCCTTAACCTGTACCTACTTTTTGGATTTACGCTGTTGG
AAGCTCTGACTGTGGCAGTTGTTGTTACTTTCTATGATGTATATATTATTCTGCAAGCTTTCATACTGACTACTACAGTATTTTTTGGTT
TGACTGTGTATACTCTACAATCTAAGAAGGATTTCAGCAAATTTGGAGCAGGCCGCTGCAGGAGCCCTTCTTTTCTGTGGATTCATCATC
TATGACACACACTCACTGATGCATAAACTGTCACCTGAAGAGTACGTATTAGCTGCCATCAGCCTCTACTTGGATATCATCAATCTATTC
CTGCACCTGTTACGGTTTCTGGAAGCAGTTAATAAAAAGTAAAACATGGCTAAAAGCTTACGGAGTAAGTGGAAAAGAAAGATGCGTGCT
GAAAAGAGAAAAAAGAATGCCCCAAAGGAGGCCAGCAGGCTTAAAAGTATTCTCAAACTAGACGGTGATGTTTTAATGAAAGATGTTCAA
GAGATAGCAACTGTGGTGGTACCCAAACCCAAACATTGCCAAGAGAAAATGCAATGTGAGGTAAAAGATGAAAAAGATGACATGAAAATG

>102200_102200_5_ZNF493-TMBIM4_ZNF493_chr19_21580069_ENST00000594390_TMBIM4_chr12_66547228_ENST00000539652_length(amino acids)=134AA_BP=
MRKVYSILSLQVLLTTVTSTVFLYFESVRTFVHESPALILLFALGSLGLIFALILNRHKYPLNLYLLFGFTLLEALTVAVVVTFYDVYII

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>102200_102200_6_ZNF493-TMBIM4_ZNF493_chr19_21580069_ENST00000594390_TMBIM4_chr12_66547228_ENST00000556010_length(transcript)=976nt_BP=135nt
ATTGTTTCTCTCTGCTGCCGGAGCTCCAGGTCTACCCTTCACTGCTCTGTGTCCTCAGCGTGTGTGGCTTCGTGACCTGAAGATACTGGG
AAATCCATAGCTAAGATGCCAGGACCCCCTGAAAGCCTAGACATGCCTTTCTGAGAAAAGTCTACAGCATTCTTTCTCTGCAGGTTCTCT
TAACTACAGTGACTTCAACAGTTTTTTTATACTTTGAGTCTGTACGGACATTTGTACATGAGAGTCCTGCCTTAATTTTGCTGTTTGCCC
TCGGATCTCTGGGTTTGATTTTTGCGTTGATTTTAAACAGACATAAGTATCCCCTTAACCTGTACCTACTTTTTGGATTTACGCTGTTGG
AAGCTCTGACTGTGGCAGTTGTTGTTACTTTCTATGATGTATATATTATTCTGCAAGCTTTCATACTGACTACTACAGTATTTTTTGGTT
TGACTGTGTATACTCTACAATCTAAGAAGGATTTCAGCAAATTTGGAGCAGGCCGCTGCAGGAGCCCTTCTTTTCTGTGGATTCATCATC
TATGACACACACTCACTGATGCATAAACTGTCACCTGAAGAGTACGTATTAGCTGCCATCAGCCTCTACTTGGATATCATCAATCTATTC
CTGCACCTGTTACGGTTTCTGGAAGCAGTTAATAAAAAGTAAAACATGGCTAAAAGCTTACGGAGTAAGTGGAAAAGAAAGATGCGTGCT
GAAAAGAGAAAAAAGAATGCCCCAAAGGAGGCCAGCAGGCTTAAAAGTATTCTCAAACTAGACGGTGATGTTTTAATGAAAGATGTTCAA
GAGATAGCAACTGTGGTGGTACCCAAACCCAAACATTGCCAAGAGAAAATGCAATGTGAGGTAAAAGATGAAAAAGATGACATGAAAATG

>102200_102200_6_ZNF493-TMBIM4_ZNF493_chr19_21580069_ENST00000594390_TMBIM4_chr12_66547228_ENST00000556010_length(amino acids)=134AA_BP=
MRKVYSILSLQVLLTTVTSTVFLYFESVRTFVHESPALILLFALGSLGLIFALILNRHKYPLNLYLLFGFTLLEALTVAVVVTFYDVYII

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>102200_102200_7_ZNF493-TMBIM4_ZNF493_chr19_21580069_ENST00000596302_TMBIM4_chr12_66547228_ENST00000539652_length(transcript)=1002nt_BP=149nt
GATGTGGCTGGGCCATTGTTTCTCTCTGCTGCCGGAGCTCCAGGTCTACCCTTCACTGCTCTGTGTCCTCAGCGTGTGTGGCTTCGTGAC
CTGAAGATACTGGGAAATCCATAGCTAAGATGCCAGGACCCCCTGAAAGCCTAGACATGCCTTTCTGAGAAAAGTCTACAGCATTCTTTC
TCTGCAGGTTCTCTTAACTACAGTGACTTCAACAGTTTTTTTATACTTTGAGTCTGTACGGACATTTGTACATGAGAGTCCTGCCTTAAT
TTTGCTGTTTGCCCTCGGATCTCTGGGTTTGATTTTTGCGTTGATTTTAAACAGACATAAGTATCCCCTTAACCTGTACCTACTTTTTGG
ATTTACGCTGTTGGAAGCTCTGACTGTGGCAGTTGTTGTTACTTTCTATGATGTATATATTATTCTGCAAGCTTTCATACTGACTACTAC
AGTATTTTTTGGTTTGACTGTGTATACTCTACAATCTAAGAAGGATTTCAGCAAATTTGGAGCAGGCCGCTGCAGGAGCCCTTCTTTTCT
GTGGATTCATCATCTATGACACACACTCACTGATGCATAAACTGTCACCTGAAGAGTACGTATTAGCTGCCATCAGCCTCTACTTGGATA
TCATCAATCTATTCCTGCACCTGTTACGGTTTCTGGAAGCAGTTAATAAAAAGTAAAACATGGCTAAAAGCTTACGGAGTAAGTGGAAAA
GAAAGATGCGTGCTGAAAAGAGAAAAAAGAATGCCCCAAAGGAGGCCAGCAGGCTTAAAAGTATTCTCAAACTAGACGGTGATGTTTTAA
TGAAAGATGTTCAAGAGATAGCAACTGTGGTGGTACCCAAACCCAAACATTGCCAAGAGAAAATGCAATGTGAGGTAAAAGATGAAAAAG
ATGACATGAAAATGGAGACTGATATTAAGAGAAACAAAAAGACTCTTCTAGACCAGCATGGACAGTACCCAATATGGATGAACCAAAGGC

>102200_102200_7_ZNF493-TMBIM4_ZNF493_chr19_21580069_ENST00000596302_TMBIM4_chr12_66547228_ENST00000539652_length(amino acids)=134AA_BP=
MRKVYSILSLQVLLTTVTSTVFLYFESVRTFVHESPALILLFALGSLGLIFALILNRHKYPLNLYLLFGFTLLEALTVAVVVTFYDVYII

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>102200_102200_8_ZNF493-TMBIM4_ZNF493_chr19_21580069_ENST00000596302_TMBIM4_chr12_66547228_ENST00000556010_length(transcript)=990nt_BP=149nt
GATGTGGCTGGGCCATTGTTTCTCTCTGCTGCCGGAGCTCCAGGTCTACCCTTCACTGCTCTGTGTCCTCAGCGTGTGTGGCTTCGTGAC
CTGAAGATACTGGGAAATCCATAGCTAAGATGCCAGGACCCCCTGAAAGCCTAGACATGCCTTTCTGAGAAAAGTCTACAGCATTCTTTC
TCTGCAGGTTCTCTTAACTACAGTGACTTCAACAGTTTTTTTATACTTTGAGTCTGTACGGACATTTGTACATGAGAGTCCTGCCTTAAT
TTTGCTGTTTGCCCTCGGATCTCTGGGTTTGATTTTTGCGTTGATTTTAAACAGACATAAGTATCCCCTTAACCTGTACCTACTTTTTGG
ATTTACGCTGTTGGAAGCTCTGACTGTGGCAGTTGTTGTTACTTTCTATGATGTATATATTATTCTGCAAGCTTTCATACTGACTACTAC
AGTATTTTTTGGTTTGACTGTGTATACTCTACAATCTAAGAAGGATTTCAGCAAATTTGGAGCAGGCCGCTGCAGGAGCCCTTCTTTTCT
GTGGATTCATCATCTATGACACACACTCACTGATGCATAAACTGTCACCTGAAGAGTACGTATTAGCTGCCATCAGCCTCTACTTGGATA
TCATCAATCTATTCCTGCACCTGTTACGGTTTCTGGAAGCAGTTAATAAAAAGTAAAACATGGCTAAAAGCTTACGGAGTAAGTGGAAAA
GAAAGATGCGTGCTGAAAAGAGAAAAAAGAATGCCCCAAAGGAGGCCAGCAGGCTTAAAAGTATTCTCAAACTAGACGGTGATGTTTTAA
TGAAAGATGTTCAAGAGATAGCAACTGTGGTGGTACCCAAACCCAAACATTGCCAAGAGAAAATGCAATGTGAGGTAAAAGATGAAAAAG
ATGACATGAAAATGGAGACTGATATTAAGAGAAACAAAAAGACTCTTCTAGACCAGCATGGACAGTACCCAATATGGATGAACCAAAGGC

>102200_102200_8_ZNF493-TMBIM4_ZNF493_chr19_21580069_ENST00000596302_TMBIM4_chr12_66547228_ENST00000556010_length(amino acids)=134AA_BP=
MRKVYSILSLQVLLTTVTSTVFLYFESVRTFVHESPALILLFALGSLGLIFALILNRHKYPLNLYLLFGFTLLEALTVAVVVTFYDVYII

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Fusion Gene PPI Analysis for ZNF493-TMBIM4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF493-TMBIM4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF493-TMBIM4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource