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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF562-ANXA2 (FusionGDB2 ID:102373)

Fusion Gene Summary for ZNF562-ANXA2

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF562-ANXA2
Fusion gene ID: 102373
HgeneTgene
Gene symbol

ZNF562

ANXA2

Gene ID

54811

302

Gene namezinc finger protein 562annexin A2
Synonyms-ANX2|ANX2L4|CAL1H|HEL-S-270|LIP2|LPC2|LPC2D|P36|PAP-IV
Cytomap

19p13.2

15q22.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 562annexin A2annexin IIannexin-2calpactin I heavy chaincalpactin I heavy polypeptidecalpactin-1 heavy chainchromobindin 8epididymis secretory protein Li 270epididymis secretory sperm binding proteinlipocortin IIplacental anticoagulant protein IVpr
Modification date2020031320200313
UniProtAcc.

A6NMY6

Ensembl transtripts involved in fusion geneENST00000448622, ENST00000453372, 
ENST00000587392, ENST00000590155, 
ENST00000537617, ENST00000293648, 
ENST00000453792, ENST00000541032, 
ENST00000557937, ENST00000332680, 
ENST00000396024, ENST00000421017, 
ENST00000451270, 
Fusion gene scores* DoF score7 X 6 X 5=21033 X 12 X 13=5148
# samples 639
** MAII scorelog2(6/210*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(39/5148*10)=-3.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF562 [Title/Abstract] AND ANXA2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF562(9770054)-ANXA2(60646412), # samples:1
Anticipated loss of major functional domain due to fusion event.ZNF562-ANXA2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ZNF562-ANXA2 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneANXA2

GO:0001921

positive regulation of receptor recycling

22848640

TgeneANXA2

GO:0031340

positive regulation of vesicle fusion

2138016

TgeneANXA2

GO:0032804

negative regulation of low-density lipoprotein particle receptor catabolic process

22848640

TgeneANXA2

GO:0036035

osteoclast development

7961821

TgeneANXA2

GO:1905581

positive regulation of low-density lipoprotein particle clearance

22848640

TgeneANXA2

GO:1905597

positive regulation of low-density lipoprotein particle receptor binding

22848640

TgeneANXA2

GO:1905602

positive regulation of receptor-mediated endocytosis involved in cholesterol transport

22848640


check buttonFusion gene breakpoints across ZNF562 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ANXA2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-4292ZNF562chr19

9770054

-ANXA2chr15

60646412

-


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Fusion Gene ORF analysis for ZNF562-ANXA2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000448622ENST00000557937ZNF562chr19

9770054

-ANXA2chr15

60646412

-
5CDS-intronENST00000453372ENST00000557937ZNF562chr19

9770054

-ANXA2chr15

60646412

-
5CDS-intronENST00000587392ENST00000557937ZNF562chr19

9770054

-ANXA2chr15

60646412

-
5CDS-intronENST00000590155ENST00000557937ZNF562chr19

9770054

-ANXA2chr15

60646412

-
5UTR-3CDSENST00000537617ENST00000332680ZNF562chr19

9770054

-ANXA2chr15

60646412

-
5UTR-3CDSENST00000537617ENST00000396024ZNF562chr19

9770054

-ANXA2chr15

60646412

-
5UTR-3CDSENST00000537617ENST00000421017ZNF562chr19

9770054

-ANXA2chr15

60646412

-
5UTR-3CDSENST00000537617ENST00000451270ZNF562chr19

9770054

-ANXA2chr15

60646412

-
5UTR-intronENST00000537617ENST00000557937ZNF562chr19

9770054

-ANXA2chr15

60646412

-
Frame-shiftENST00000453372ENST00000332680ZNF562chr19

9770054

-ANXA2chr15

60646412

-
Frame-shiftENST00000453372ENST00000396024ZNF562chr19

9770054

-ANXA2chr15

60646412

-
Frame-shiftENST00000453372ENST00000421017ZNF562chr19

9770054

-ANXA2chr15

60646412

-
Frame-shiftENST00000453372ENST00000451270ZNF562chr19

9770054

-ANXA2chr15

60646412

-
Frame-shiftENST00000587392ENST00000332680ZNF562chr19

9770054

-ANXA2chr15

60646412

-
Frame-shiftENST00000587392ENST00000396024ZNF562chr19

9770054

-ANXA2chr15

60646412

-
Frame-shiftENST00000587392ENST00000421017ZNF562chr19

9770054

-ANXA2chr15

60646412

-
Frame-shiftENST00000587392ENST00000451270ZNF562chr19

9770054

-ANXA2chr15

60646412

-
Frame-shiftENST00000590155ENST00000332680ZNF562chr19

9770054

-ANXA2chr15

60646412

-
Frame-shiftENST00000590155ENST00000396024ZNF562chr19

9770054

-ANXA2chr15

60646412

-
Frame-shiftENST00000590155ENST00000421017ZNF562chr19

9770054

-ANXA2chr15

60646412

-
Frame-shiftENST00000590155ENST00000451270ZNF562chr19

9770054

-ANXA2chr15

60646412

-
In-frameENST00000448622ENST00000332680ZNF562chr19

9770054

-ANXA2chr15

60646412

-
In-frameENST00000448622ENST00000396024ZNF562chr19

9770054

-ANXA2chr15

60646412

-
In-frameENST00000448622ENST00000421017ZNF562chr19

9770054

-ANXA2chr15

60646412

-
In-frameENST00000448622ENST00000451270ZNF562chr19

9770054

-ANXA2chr15

60646412

-
intron-3CDSENST00000293648ENST00000332680ZNF562chr19

9770054

-ANXA2chr15

60646412

-
intron-3CDSENST00000293648ENST00000396024ZNF562chr19

9770054

-ANXA2chr15

60646412

-
intron-3CDSENST00000293648ENST00000421017ZNF562chr19

9770054

-ANXA2chr15

60646412

-
intron-3CDSENST00000293648ENST00000451270ZNF562chr19

9770054

-ANXA2chr15

60646412

-
intron-3CDSENST00000453792ENST00000332680ZNF562chr19

9770054

-ANXA2chr15

60646412

-
intron-3CDSENST00000453792ENST00000396024ZNF562chr19

9770054

-ANXA2chr15

60646412

-
intron-3CDSENST00000453792ENST00000421017ZNF562chr19

9770054

-ANXA2chr15

60646412

-
intron-3CDSENST00000453792ENST00000451270ZNF562chr19

9770054

-ANXA2chr15

60646412

-
intron-3CDSENST00000541032ENST00000332680ZNF562chr19

9770054

-ANXA2chr15

60646412

-
intron-3CDSENST00000541032ENST00000396024ZNF562chr19

9770054

-ANXA2chr15

60646412

-
intron-3CDSENST00000541032ENST00000421017ZNF562chr19

9770054

-ANXA2chr15

60646412

-
intron-3CDSENST00000541032ENST00000451270ZNF562chr19

9770054

-ANXA2chr15

60646412

-
intron-intronENST00000293648ENST00000557937ZNF562chr19

9770054

-ANXA2chr15

60646412

-
intron-intronENST00000453792ENST00000557937ZNF562chr19

9770054

-ANXA2chr15

60646412

-
intron-intronENST00000541032ENST00000557937ZNF562chr19

9770054

-ANXA2chr15

60646412

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000448622ZNF562chr199770054-ENST00000396024ANXA2chr1560646412-1265277903262213
ENST00000448622ZNF562chr199770054-ENST00000451270ANXA2chr1560646412-1072277903262213
ENST00000448622ZNF562chr199770054-ENST00000332680ANXA2chr1560646412-1067277903262213
ENST00000448622ZNF562chr199770054-ENST00000421017ANXA2chr1560646412-1057277903262213

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000448622ENST00000396024ZNF562chr199770054-ANXA2chr1560646412-0.0017102940.99828964
ENST00000448622ENST00000451270ZNF562chr199770054-ANXA2chr1560646412-0.0019773720.9980227
ENST00000448622ENST00000332680ZNF562chr199770054-ANXA2chr1560646412-0.0020226640.9979773
ENST00000448622ENST00000421017ZNF562chr199770054-ANXA2chr1560646412-0.0021262450.9978738

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Fusion Genomic Features for ZNF562-ANXA2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF562-ANXA2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:9770054/chr15:60646412)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ANXA2

A6NMY6

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneANXA2chr19:9770054chr15:60646412ENST00000332680613265_336194358.0RepeatAnnexin 4
TgeneANXA2chr19:9770054chr15:60646412ENST00000396024714189_261176340.0RepeatAnnexin 3
TgeneANXA2chr19:9770054chr15:60646412ENST00000396024714265_336176340.0RepeatAnnexin 4
TgeneANXA2chr19:9770054chr15:60646412ENST00000421017714189_261176340.0RepeatAnnexin 3
TgeneANXA2chr19:9770054chr15:60646412ENST00000421017714265_336176340.0RepeatAnnexin 4
TgeneANXA2chr19:9770054chr15:60646412ENST00000451270613189_261176340.0RepeatAnnexin 3
TgeneANXA2chr19:9770054chr15:60646412ENST00000451270613265_336176340.0RepeatAnnexin 4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF562chr19:9770054chr15:60646412ENST00000293648-1441_1200355.0DomainKRAB
HgeneZNF562chr19:9770054chr15:60646412ENST00000448622-3641_12038427.0DomainKRAB
HgeneZNF562chr19:9770054chr15:60646412ENST00000453372-3641_12038427.0DomainKRAB
HgeneZNF562chr19:9770054chr15:60646412ENST00000293648-14176_1980355.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF562chr19:9770054chr15:60646412ENST00000293648-14204_2260355.0Zinc fingerC2H2-type 2
HgeneZNF562chr19:9770054chr15:60646412ENST00000293648-14260_2820355.0Zinc fingerC2H2-type 3%3B degenerate
HgeneZNF562chr19:9770054chr15:60646412ENST00000293648-14288_3100355.0Zinc fingerC2H2-type 4
HgeneZNF562chr19:9770054chr15:60646412ENST00000293648-14316_3380355.0Zinc fingerC2H2-type 5
HgeneZNF562chr19:9770054chr15:60646412ENST00000293648-14344_3660355.0Zinc fingerC2H2-type 6
HgeneZNF562chr19:9770054chr15:60646412ENST00000293648-14372_3940355.0Zinc fingerC2H2-type 7
HgeneZNF562chr19:9770054chr15:60646412ENST00000293648-14400_4220355.0Zinc fingerC2H2-type 8
HgeneZNF562chr19:9770054chr15:60646412ENST00000448622-36176_19838427.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF562chr19:9770054chr15:60646412ENST00000448622-36204_22638427.0Zinc fingerC2H2-type 2
HgeneZNF562chr19:9770054chr15:60646412ENST00000448622-36260_28238427.0Zinc fingerC2H2-type 3%3B degenerate
HgeneZNF562chr19:9770054chr15:60646412ENST00000448622-36288_31038427.0Zinc fingerC2H2-type 4
HgeneZNF562chr19:9770054chr15:60646412ENST00000448622-36316_33838427.0Zinc fingerC2H2-type 5
HgeneZNF562chr19:9770054chr15:60646412ENST00000448622-36344_36638427.0Zinc fingerC2H2-type 6
HgeneZNF562chr19:9770054chr15:60646412ENST00000448622-36372_39438427.0Zinc fingerC2H2-type 7
HgeneZNF562chr19:9770054chr15:60646412ENST00000448622-36400_42238427.0Zinc fingerC2H2-type 8
HgeneZNF562chr19:9770054chr15:60646412ENST00000453372-36176_19838427.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF562chr19:9770054chr15:60646412ENST00000453372-36204_22638427.0Zinc fingerC2H2-type 2
HgeneZNF562chr19:9770054chr15:60646412ENST00000453372-36260_28238427.0Zinc fingerC2H2-type 3%3B degenerate
HgeneZNF562chr19:9770054chr15:60646412ENST00000453372-36288_31038427.0Zinc fingerC2H2-type 4
HgeneZNF562chr19:9770054chr15:60646412ENST00000453372-36316_33838427.0Zinc fingerC2H2-type 5
HgeneZNF562chr19:9770054chr15:60646412ENST00000453372-36344_36638427.0Zinc fingerC2H2-type 6
HgeneZNF562chr19:9770054chr15:60646412ENST00000453372-36372_39438427.0Zinc fingerC2H2-type 7
HgeneZNF562chr19:9770054chr15:60646412ENST00000453372-36400_42238427.0Zinc fingerC2H2-type 8
TgeneANXA2chr19:9770054chr15:60646412ENST000003326806132_24194358.0RegionS100A10-binding site
TgeneANXA2chr19:9770054chr15:60646412ENST000003960247142_24176340.0RegionS100A10-binding site
TgeneANXA2chr19:9770054chr15:60646412ENST000004210177142_24176340.0RegionS100A10-binding site
TgeneANXA2chr19:9770054chr15:60646412ENST000004512706132_24176340.0RegionS100A10-binding site
TgeneANXA2chr19:9770054chr15:60646412ENST00000332680613105_176194358.0RepeatAnnexin 2
TgeneANXA2chr19:9770054chr15:60646412ENST00000332680613189_261194358.0RepeatAnnexin 3
TgeneANXA2chr19:9770054chr15:60646412ENST0000033268061333_104194358.0RepeatAnnexin 1
TgeneANXA2chr19:9770054chr15:60646412ENST00000396024714105_176176340.0RepeatAnnexin 2
TgeneANXA2chr19:9770054chr15:60646412ENST0000039602471433_104176340.0RepeatAnnexin 1
TgeneANXA2chr19:9770054chr15:60646412ENST00000421017714105_176176340.0RepeatAnnexin 2
TgeneANXA2chr19:9770054chr15:60646412ENST0000042101771433_104176340.0RepeatAnnexin 1
TgeneANXA2chr19:9770054chr15:60646412ENST00000451270613105_176176340.0RepeatAnnexin 2
TgeneANXA2chr19:9770054chr15:60646412ENST0000045127061333_104176340.0RepeatAnnexin 1


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Fusion Gene Sequence for ZNF562-ANXA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>102373_102373_1_ZNF562-ANXA2_ZNF562_chr19_9770054_ENST00000448622_ANXA2_chr15_60646412_ENST00000332680_length(transcript)=1067nt_BP=277nt
AGTGTGCCACCGCCATCTTTACCGGCTGTGGCTCAGCATGGTCAGTGCCGTTTAACCTTTATTGTGGTGGAGTCCACCCCGCTGTGATTC
ATAAGCTGCCCTGAGGCGATCTTGGCATCAAGAAAGACAGCATTGAGGCACATCTCACCATCAGCTTCAGAGGATGTCAGCCTTTGATAT
GTCCCATGGGTTTTTTCCCAGGGAACCAATCTGTCCTTTTGAAGAAAAGACAAAGATAGGAACGATGGTAGAGGACCACCGGTCAAATTC
TTACCAGGGTAGAAGAGCAGAGGATGGCTCTGTCATTGATTATGAACTGATTGACCAAGATGCTCGGGATCTCTATGACGCTGGAGTGAA
GAGGAAAGGAACTGATGTTCCCAAGTGGATCAGCATCATGACCGAGCGGAGCGTGCCCCACCTCCAGAAAGTATTTGATAGGTACAAGAG
TTACAGCCCTTATGACATGTTGGAAAGCATCAGGAAAGAGGTTAAAGGAGACCTGGAAAATGCTTTCCTGAACCTGGTTCAGTGCATTCA
GAACAAGCCCCTGTATTTTGCTGATCGGCTGTATGACTCCATGAAGGGCAAGGGGACGCGAGATAAGGTCCTGATCAGAATCATGGTCTC
CCGCAGTGAAGTGGACATGTTGAAAATTAGGTCTGAATTCAAGAGAAAGTACGGCAAGTCCCTGTACTATTATATCCAGCAAGACACTAA
GGGCGACTACCAGAAAGCGCTGCTGTACCTGTGTGGTGGAGATGACTGAAGCCCGACACGGCCTGAGCGTCCAGAAATGGTGCTCACCAT
GCTTCCAGCTAACAGGTCTAGAAAACCAGCTTGCGAATAACAGTCCCCGTGGCCATCCCTGTGAGGGTGACGTTAGCATTACCCCCAACC
TCATTTTAGTTGCCTAAGCATTGCCTGGCCTTCCTGTCTAGTCTCTCCTGTAAGCCAAAGAAATGAACATTCCAAGGAGTTGGAAGTGAA

>102373_102373_1_ZNF562-ANXA2_ZNF562_chr19_9770054_ENST00000448622_ANXA2_chr15_60646412_ENST00000332680_length(amino acids)=213AA_BP=0
MRLGVMLTSPSQGWPRGLLFASWFSRPVSWKHGEHHFWTLRPCRASVISTTQVQQRFLVVALSVLLDIIVQGLAVLSLEFRPNFQHVHFT
AGDHDSDQDLISRPLALHGVIQPISKIQGLVLNALNQVQESIFQVSFNLFPDAFQHVIRAVTLVPIKYFLEVGHAPLGHDADPLGNISSF

--------------------------------------------------------------
>102373_102373_2_ZNF562-ANXA2_ZNF562_chr19_9770054_ENST00000448622_ANXA2_chr15_60646412_ENST00000396024_length(transcript)=1265nt_BP=277nt
AGTGTGCCACCGCCATCTTTACCGGCTGTGGCTCAGCATGGTCAGTGCCGTTTAACCTTTATTGTGGTGGAGTCCACCCCGCTGTGATTC
ATAAGCTGCCCTGAGGCGATCTTGGCATCAAGAAAGACAGCATTGAGGCACATCTCACCATCAGCTTCAGAGGATGTCAGCCTTTGATAT
GTCCCATGGGTTTTTTCCCAGGGAACCAATCTGTCCTTTTGAAGAAAAGACAAAGATAGGAACGATGGTAGAGGACCACCGGTCAAATTC
TTACCAGGGTAGAAGAGCAGAGGATGGCTCTGTCATTGATTATGAACTGATTGACCAAGATGCTCGGGATCTCTATGACGCTGGAGTGAA
GAGGAAAGGAACTGATGTTCCCAAGTGGATCAGCATCATGACCGAGCGGAGCGTGCCCCACCTCCAGAAAGTATTTGATAGGTACAAGAG
TTACAGCCCTTATGACATGTTGGAAAGCATCAGGAAAGAGGTTAAAGGAGACCTGGAAAATGCTTTCCTGAACCTGGTTCAGTGCATTCA
GAACAAGCCCCTGTATTTTGCTGATCGGCTGTATGACTCCATGAAGGGCAAGGGGACGCGAGATAAGGTCCTGATCAGAATCATGGTCTC
CCGCAGTGAAGTGGACATGTTGAAAATTAGGTCTGAATTCAAGAGAAAGTACGGCAAGTCCCTGTACTATTATATCCAGCAAGACACTAA
GGGCGACTACCAGAAAGCGCTGCTGTACCTGTGTGGTGGAGATGACTGAAGCCCGACACGGCCTGAGCGTCCAGAAATGGTGCTCACCAT
GCTTCCAGCTAACAGGTCTAGAAAACCAGCTTGCGAATAACAGTCCCCGTGGCCATCCCTGTGAGGGTGACGTTAGCATTACCCCCAACC
TCATTTTAGTTGCCTAAGCATTGCCTGGCCTTCCTGTCTAGTCTCTCCTGTAAGCCAAAGAAATGAACATTCCAAGGAGTTGGAAGTGAA
GTCTATGATGTGAAACACTTTGCCTCCTGTGTACTGTGTCATAAACAGATGAATAAACTGAATTTGTACTTTAGAAACACGTACTTTGTG
GCCCTGCTTTCAACTGAATTGTTTGAAAATTAAACGTGCTTGGGGTTCAGCTGGTGAGGCTGTCCCTGTAGGAAGAAAGCTCTGGGACTG
AGCTGTACAGTATGGTTGCCCCTATCCAAGTGTCGCTATTTAAGTTAAATTTAAATGAAATAAAATAAAATAAAATCAGTTCCTGAGTCA

>102373_102373_2_ZNF562-ANXA2_ZNF562_chr19_9770054_ENST00000448622_ANXA2_chr15_60646412_ENST00000396024_length(amino acids)=213AA_BP=0
MRLGVMLTSPSQGWPRGLLFASWFSRPVSWKHGEHHFWTLRPCRASVISTTQVQQRFLVVALSVLLDIIVQGLAVLSLEFRPNFQHVHFT
AGDHDSDQDLISRPLALHGVIQPISKIQGLVLNALNQVQESIFQVSFNLFPDAFQHVIRAVTLVPIKYFLEVGHAPLGHDADPLGNISSF

--------------------------------------------------------------
>102373_102373_3_ZNF562-ANXA2_ZNF562_chr19_9770054_ENST00000448622_ANXA2_chr15_60646412_ENST00000421017_length(transcript)=1057nt_BP=277nt
AGTGTGCCACCGCCATCTTTACCGGCTGTGGCTCAGCATGGTCAGTGCCGTTTAACCTTTATTGTGGTGGAGTCCACCCCGCTGTGATTC
ATAAGCTGCCCTGAGGCGATCTTGGCATCAAGAAAGACAGCATTGAGGCACATCTCACCATCAGCTTCAGAGGATGTCAGCCTTTGATAT
GTCCCATGGGTTTTTTCCCAGGGAACCAATCTGTCCTTTTGAAGAAAAGACAAAGATAGGAACGATGGTAGAGGACCACCGGTCAAATTC
TTACCAGGGTAGAAGAGCAGAGGATGGCTCTGTCATTGATTATGAACTGATTGACCAAGATGCTCGGGATCTCTATGACGCTGGAGTGAA
GAGGAAAGGAACTGATGTTCCCAAGTGGATCAGCATCATGACCGAGCGGAGCGTGCCCCACCTCCAGAAAGTATTTGATAGGTACAAGAG
TTACAGCCCTTATGACATGTTGGAAAGCATCAGGAAAGAGGTTAAAGGAGACCTGGAAAATGCTTTCCTGAACCTGGTTCAGTGCATTCA
GAACAAGCCCCTGTATTTTGCTGATCGGCTGTATGACTCCATGAAGGGCAAGGGGACGCGAGATAAGGTCCTGATCAGAATCATGGTCTC
CCGCAGTGAAGTGGACATGTTGAAAATTAGGTCTGAATTCAAGAGAAAGTACGGCAAGTCCCTGTACTATTATATCCAGCAAGACACTAA
GGGCGACTACCAGAAAGCGCTGCTGTACCTGTGTGGTGGAGATGACTGAAGCCCGACACGGCCTGAGCGTCCAGAAATGGTGCTCACCAT
GCTTCCAGCTAACAGGTCTAGAAAACCAGCTTGCGAATAACAGTCCCCGTGGCCATCCCTGTGAGGGTGACGTTAGCATTACCCCCAACC
TCATTTTAGTTGCCTAAGCATTGCCTGGCCTTCCTGTCTAGTCTCTCCTGTAAGCCAAAGAAATGAACATTCCAAGGAGTTGGAAGTGAA

>102373_102373_3_ZNF562-ANXA2_ZNF562_chr19_9770054_ENST00000448622_ANXA2_chr15_60646412_ENST00000421017_length(amino acids)=213AA_BP=0
MRLGVMLTSPSQGWPRGLLFASWFSRPVSWKHGEHHFWTLRPCRASVISTTQVQQRFLVVALSVLLDIIVQGLAVLSLEFRPNFQHVHFT
AGDHDSDQDLISRPLALHGVIQPISKIQGLVLNALNQVQESIFQVSFNLFPDAFQHVIRAVTLVPIKYFLEVGHAPLGHDADPLGNISSF

--------------------------------------------------------------
>102373_102373_4_ZNF562-ANXA2_ZNF562_chr19_9770054_ENST00000448622_ANXA2_chr15_60646412_ENST00000451270_length(transcript)=1072nt_BP=277nt
AGTGTGCCACCGCCATCTTTACCGGCTGTGGCTCAGCATGGTCAGTGCCGTTTAACCTTTATTGTGGTGGAGTCCACCCCGCTGTGATTC
ATAAGCTGCCCTGAGGCGATCTTGGCATCAAGAAAGACAGCATTGAGGCACATCTCACCATCAGCTTCAGAGGATGTCAGCCTTTGATAT
GTCCCATGGGTTTTTTCCCAGGGAACCAATCTGTCCTTTTGAAGAAAAGACAAAGATAGGAACGATGGTAGAGGACCACCGGTCAAATTC
TTACCAGGGTAGAAGAGCAGAGGATGGCTCTGTCATTGATTATGAACTGATTGACCAAGATGCTCGGGATCTCTATGACGCTGGAGTGAA
GAGGAAAGGAACTGATGTTCCCAAGTGGATCAGCATCATGACCGAGCGGAGCGTGCCCCACCTCCAGAAAGTATTTGATAGGTACAAGAG
TTACAGCCCTTATGACATGTTGGAAAGCATCAGGAAAGAGGTTAAAGGAGACCTGGAAAATGCTTTCCTGAACCTGGTTCAGTGCATTCA
GAACAAGCCCCTGTATTTTGCTGATCGGCTGTATGACTCCATGAAGGGCAAGGGGACGCGAGATAAGGTCCTGATCAGAATCATGGTCTC
CCGCAGTGAAGTGGACATGTTGAAAATTAGGTCTGAATTCAAGAGAAAGTACGGCAAGTCCCTGTACTATTATATCCAGCAAGACACTAA
GGGCGACTACCAGAAAGCGCTGCTGTACCTGTGTGGTGGAGATGACTGAAGCCCGACACGGCCTGAGCGTCCAGAAATGGTGCTCACCAT
GCTTCCAGCTAACAGGTCTAGAAAACCAGCTTGCGAATAACAGTCCCCGTGGCCATCCCTGTGAGGGTGACGTTAGCATTACCCCCAACC
TCATTTTAGTTGCCTAAGCATTGCCTGGCCTTCCTGTCTAGTCTCTCCTGTAAGCCAAAGAAATGAACATTCCAAGGAGTTGGAAGTGAA

>102373_102373_4_ZNF562-ANXA2_ZNF562_chr19_9770054_ENST00000448622_ANXA2_chr15_60646412_ENST00000451270_length(amino acids)=213AA_BP=0
MRLGVMLTSPSQGWPRGLLFASWFSRPVSWKHGEHHFWTLRPCRASVISTTQVQQRFLVVALSVLLDIIVQGLAVLSLEFRPNFQHVHFT
AGDHDSDQDLISRPLALHGVIQPISKIQGLVLNALNQVQESIFQVSFNLFPDAFQHVIRAVTLVPIKYFLEVGHAPLGHDADPLGNISSF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZNF562-ANXA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF562-ANXA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF562-ANXA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource