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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF562-EIF5 (FusionGDB2 ID:102375)

Fusion Gene Summary for ZNF562-EIF5

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF562-EIF5
Fusion gene ID: 102375
HgeneTgene
Gene symbol

ZNF562

EIF5

Gene ID

54811

1983

Gene namezinc finger protein 562eukaryotic translation initiation factor 5
Synonyms-EIF-5|EIF-5A
Cytomap

19p13.2

14q32.32

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 562eukaryotic translation initiation factor 5
Modification date2020031320200313
UniProtAcc.

O60841

Ensembl transtripts involved in fusion geneENST00000293648, ENST00000448622, 
ENST00000453372, ENST00000541032, 
ENST00000587392, ENST00000590155, 
ENST00000537617, ENST00000453792, 
ENST00000392715, ENST00000560200, 
ENST00000216554, ENST00000558506, 
Fusion gene scores* DoF score7 X 6 X 5=21011 X 10 X 6=660
# samples 613
** MAII scorelog2(6/210*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/660*10)=-2.34395440121736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF562 [Title/Abstract] AND EIF5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF562(9771395)-EIF5(103803013), # samples:1
Anticipated loss of major functional domain due to fusion event.ZNF562-EIF5 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ZNF562-EIF5 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ZNF562-EIF5 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ZNF562-EIF5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneEIF5

GO:0006446

regulation of translational initiation

22156057


check buttonFusion gene breakpoints across ZNF562 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EIF5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-KN-8437-11AZNF562chr19

9771395

-EIF5chr14

103803013

+


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Fusion Gene ORF analysis for ZNF562-EIF5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000293648ENST00000392715ZNF562chr19

9771395

-EIF5chr14

103803013

+
5CDS-3UTRENST00000293648ENST00000560200ZNF562chr19

9771395

-EIF5chr14

103803013

+
5CDS-3UTRENST00000448622ENST00000392715ZNF562chr19

9771395

-EIF5chr14

103803013

+
5CDS-3UTRENST00000448622ENST00000560200ZNF562chr19

9771395

-EIF5chr14

103803013

+
5CDS-3UTRENST00000453372ENST00000392715ZNF562chr19

9771395

-EIF5chr14

103803013

+
5CDS-3UTRENST00000453372ENST00000560200ZNF562chr19

9771395

-EIF5chr14

103803013

+
5CDS-3UTRENST00000541032ENST00000392715ZNF562chr19

9771395

-EIF5chr14

103803013

+
5CDS-3UTRENST00000541032ENST00000560200ZNF562chr19

9771395

-EIF5chr14

103803013

+
5CDS-3UTRENST00000587392ENST00000392715ZNF562chr19

9771395

-EIF5chr14

103803013

+
5CDS-3UTRENST00000587392ENST00000560200ZNF562chr19

9771395

-EIF5chr14

103803013

+
5CDS-3UTRENST00000590155ENST00000392715ZNF562chr19

9771395

-EIF5chr14

103803013

+
5CDS-3UTRENST00000590155ENST00000560200ZNF562chr19

9771395

-EIF5chr14

103803013

+
5UTR-3CDSENST00000537617ENST00000216554ZNF562chr19

9771395

-EIF5chr14

103803013

+
5UTR-3CDSENST00000537617ENST00000558506ZNF562chr19

9771395

-EIF5chr14

103803013

+
5UTR-3UTRENST00000537617ENST00000392715ZNF562chr19

9771395

-EIF5chr14

103803013

+
5UTR-3UTRENST00000537617ENST00000560200ZNF562chr19

9771395

-EIF5chr14

103803013

+
Frame-shiftENST00000293648ENST00000216554ZNF562chr19

9771395

-EIF5chr14

103803013

+
Frame-shiftENST00000293648ENST00000558506ZNF562chr19

9771395

-EIF5chr14

103803013

+
Frame-shiftENST00000453372ENST00000216554ZNF562chr19

9771395

-EIF5chr14

103803013

+
Frame-shiftENST00000453372ENST00000558506ZNF562chr19

9771395

-EIF5chr14

103803013

+
Frame-shiftENST00000541032ENST00000216554ZNF562chr19

9771395

-EIF5chr14

103803013

+
Frame-shiftENST00000541032ENST00000558506ZNF562chr19

9771395

-EIF5chr14

103803013

+
Frame-shiftENST00000587392ENST00000216554ZNF562chr19

9771395

-EIF5chr14

103803013

+
Frame-shiftENST00000587392ENST00000558506ZNF562chr19

9771395

-EIF5chr14

103803013

+
Frame-shiftENST00000590155ENST00000216554ZNF562chr19

9771395

-EIF5chr14

103803013

+
Frame-shiftENST00000590155ENST00000558506ZNF562chr19

9771395

-EIF5chr14

103803013

+
In-frameENST00000448622ENST00000216554ZNF562chr19

9771395

-EIF5chr14

103803013

+
In-frameENST00000448622ENST00000558506ZNF562chr19

9771395

-EIF5chr14

103803013

+
intron-3CDSENST00000453792ENST00000216554ZNF562chr19

9771395

-EIF5chr14

103803013

+
intron-3CDSENST00000453792ENST00000558506ZNF562chr19

9771395

-EIF5chr14

103803013

+
intron-3UTRENST00000453792ENST00000392715ZNF562chr19

9771395

-EIF5chr14

103803013

+
intron-3UTRENST00000453792ENST00000560200ZNF562chr19

9771395

-EIF5chr14

103803013

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000448622ZNF562chr199771395-ENST00000216554EIF5chr14103803013+53031881631329388
ENST00000448622ZNF562chr199771395-ENST00000558506EIF5chr14103803013+35061881631329388

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000448622ENST00000216554ZNF562chr199771395-EIF5chr14103803013+0.0001844140.99981564
ENST00000448622ENST00000558506ZNF562chr199771395-EIF5chr14103803013+0.0001908860.9998091

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Fusion Genomic Features for ZNF562-EIF5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ZNF562chr199771395-EIF5chr14103803013+0.99605730.003942694
ZNF562chr199771395-EIF5chr14103803013+0.99605730.003942694

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ZNF562-EIF5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:9771395/chr14:103803013)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.EIF5

O60841

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Plays a role in translation initiation. Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome. The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes. {ECO:0000250|UniProtKB:P39730}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneEIF5chr19:9771395chr14:103803013ENST00000216554312196_20251432.0Compositional biasNote=Asp/Glu-rich (highly acidic)
TgeneEIF5chr19:9771395chr14:103803013ENST00000216554312384_40251432.0Compositional biasNote=Asp/Glu-rich (highly acidic)
TgeneEIF5chr19:9771395chr14:103803013ENST00000216554312423_42951432.0Compositional biasNote=Asp-rich (acidic)
TgeneEIF5chr19:9771395chr14:103803013ENST00000392715211196_20251432.0Compositional biasNote=Asp/Glu-rich (highly acidic)
TgeneEIF5chr19:9771395chr14:103803013ENST00000392715211384_40251432.0Compositional biasNote=Asp/Glu-rich (highly acidic)
TgeneEIF5chr19:9771395chr14:103803013ENST00000392715211423_42951432.0Compositional biasNote=Asp-rich (acidic)
TgeneEIF5chr19:9771395chr14:103803013ENST00000558506110196_20251432.0Compositional biasNote=Asp/Glu-rich (highly acidic)
TgeneEIF5chr19:9771395chr14:103803013ENST00000558506110384_40251432.0Compositional biasNote=Asp/Glu-rich (highly acidic)
TgeneEIF5chr19:9771395chr14:103803013ENST00000558506110423_42951432.0Compositional biasNote=Asp-rich (acidic)
TgeneEIF5chr19:9771395chr14:103803013ENST00000216554312233_39251432.0DomainW2
TgeneEIF5chr19:9771395chr14:103803013ENST00000392715211233_39251432.0DomainW2
TgeneEIF5chr19:9771395chr14:103803013ENST00000558506110233_39251432.0DomainW2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF562chr19:9771395chr14:103803013ENST00000293648-2441_1208355.0DomainKRAB
HgeneZNF562chr19:9771395chr14:103803013ENST00000448622-2641_1208427.0DomainKRAB
HgeneZNF562chr19:9771395chr14:103803013ENST00000453372-2641_1208427.0DomainKRAB
HgeneZNF562chr19:9771395chr14:103803013ENST00000293648-24176_1988355.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF562chr19:9771395chr14:103803013ENST00000293648-24204_2268355.0Zinc fingerC2H2-type 2
HgeneZNF562chr19:9771395chr14:103803013ENST00000293648-24260_2828355.0Zinc fingerC2H2-type 3%3B degenerate
HgeneZNF562chr19:9771395chr14:103803013ENST00000293648-24288_3108355.0Zinc fingerC2H2-type 4
HgeneZNF562chr19:9771395chr14:103803013ENST00000293648-24316_3388355.0Zinc fingerC2H2-type 5
HgeneZNF562chr19:9771395chr14:103803013ENST00000293648-24344_3668355.0Zinc fingerC2H2-type 6
HgeneZNF562chr19:9771395chr14:103803013ENST00000293648-24372_3948355.0Zinc fingerC2H2-type 7
HgeneZNF562chr19:9771395chr14:103803013ENST00000293648-24400_4228355.0Zinc fingerC2H2-type 8
HgeneZNF562chr19:9771395chr14:103803013ENST00000448622-26176_1988427.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF562chr19:9771395chr14:103803013ENST00000448622-26204_2268427.0Zinc fingerC2H2-type 2
HgeneZNF562chr19:9771395chr14:103803013ENST00000448622-26260_2828427.0Zinc fingerC2H2-type 3%3B degenerate
HgeneZNF562chr19:9771395chr14:103803013ENST00000448622-26288_3108427.0Zinc fingerC2H2-type 4
HgeneZNF562chr19:9771395chr14:103803013ENST00000448622-26316_3388427.0Zinc fingerC2H2-type 5
HgeneZNF562chr19:9771395chr14:103803013ENST00000448622-26344_3668427.0Zinc fingerC2H2-type 6
HgeneZNF562chr19:9771395chr14:103803013ENST00000448622-26372_3948427.0Zinc fingerC2H2-type 7
HgeneZNF562chr19:9771395chr14:103803013ENST00000448622-26400_4228427.0Zinc fingerC2H2-type 8
HgeneZNF562chr19:9771395chr14:103803013ENST00000453372-26176_1988427.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF562chr19:9771395chr14:103803013ENST00000453372-26204_2268427.0Zinc fingerC2H2-type 2
HgeneZNF562chr19:9771395chr14:103803013ENST00000453372-26260_2828427.0Zinc fingerC2H2-type 3%3B degenerate
HgeneZNF562chr19:9771395chr14:103803013ENST00000453372-26288_3108427.0Zinc fingerC2H2-type 4
HgeneZNF562chr19:9771395chr14:103803013ENST00000453372-26316_3388427.0Zinc fingerC2H2-type 5
HgeneZNF562chr19:9771395chr14:103803013ENST00000453372-26344_3668427.0Zinc fingerC2H2-type 6
HgeneZNF562chr19:9771395chr14:103803013ENST00000453372-26372_3948427.0Zinc fingerC2H2-type 7
HgeneZNF562chr19:9771395chr14:103803013ENST00000453372-26400_4228427.0Zinc fingerC2H2-type 8
TgeneEIF5chr19:9771395chr14:103803013ENST0000021655431227_3451432.0Nucleotide bindingGTP
TgeneEIF5chr19:9771395chr14:103803013ENST0000039271521127_3451432.0Nucleotide bindingGTP
TgeneEIF5chr19:9771395chr14:103803013ENST0000055850611027_3451432.0Nucleotide bindingGTP


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Fusion Gene Sequence for ZNF562-EIF5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>102375_102375_1_ZNF562-EIF5_ZNF562_chr19_9771395_ENST00000448622_EIF5_chr14_103803013_ENST00000216554_length(transcript)=5303nt_BP=188nt
AGTGTGCCACCGCCATCTTTACCGGCTGTGGCTCAGCATGGTCAGTGCCGTTTAACCTTTATTGTGGTGGAGTCCACCCCGCTGTGATTC
ATAAGCTGCCCTGAGGCGATCTTGGCATCAAGAAAGACAGCATTGAGGCACATCTCACCATCAGCTTCAGAGGATGTCAGCCTTTGATAT
GTCCCATGATCCCACCAAATATTTTGGTTGTGAGCTGGGAGCACAGACCCAGTTTGATGTTAAGAATGACCGTTACATTGTCAATGGATC
TCATGAGGCGAATAAGCTGCAAGACATGTTGGATGGATTCATTAAAAAATTTGTTCTCTGTCCTGAATGTGAGAATCCTGAAACAGATTT
GCATGTCAATCCAAAGAAGCAAACAATAGGTAATTCTTGTAAAGCCTGTGGCTATCGAGGCATGCTTGACACACATCATAAACTCTGCAC
ATTCATTCTCAAAAACCCACCTGAGAATAGTGACAGTGGTACAGGAAAGAAAGAAAAAGAAAAGAAAAACAGAAAGGGCAAAGACAAGGA
AAATGGCTCCGTATCCAGCAGTGAGACACCACCACCACCACCACCACCAAATGAAATTAATCCTCCTCCACATACAATGGAAGAAGAGGA
GGATGATGACTGGGGAGAAGATACAACTGAGGAAGCTCAAAGGCGTCGAATGGATGAAATCAGTGACCATGCAAAAGTTCTGACACTCAG
TGATGATTTGGAAAGAACAATTGAGGAGAGGGTCAATATCCTCTTTGATTTTGTTAAGAAAAAGAAAGAAGAGGGTGTTATTGATTCATC
TGACAAAGAAATCGTTGCTGAAGCAGAAAGACTGGATGTAAAAGCCATGGGCCCTCTTGTTCTAACTGAAGTTCTTTTTAATGAGAAGAT
TAGAGAACAGATTAAGAAATACAGGCGCCATTTCCTACGATTTTGTCACAACAACAAAAAAGCCCAACGGTACCTTCTTCATGGTTTGGA
GTGTGTGGTAGCAATGCATCAAGCTCAGCTTATCTCCAAGATTCCACATATCTTGAAGGAGATGTACGATGCAGACCTTTTAGAAGAAGA
GGTCATCATCAGCTGGTCGGAAAAGGCCTCTAAGAAATATGTCTCCAAAGAACTTGCCAAAGAGATTCGTGTCAAAGCAGAACCATTTAT
AAAATGGTTGAAGGAGGCAGAGGAAGAATCTTCTGGTGGCGAAGAAGAAGATGAAGATGAGAACATTGAGGTGGTGTATTCGAAGGCTGC
CAGTGTACCGAAAGTTGAGACTGTAAAGTCAGACAACAAGGATGACGACATCGATATTGATGCCATTTAAAGGGATGGATGCAACCTAGC
TTAACAGTATAATGCTGCAAATTTTCCTCCATTATCAGCCAGAAGTGCAACATGTATGTGCAAAAGCTAAAATGGCTTAACATCATGCTA
CACTTTACACTAAAAATCTATTACTGTGAGTGGTCTGTTATTAAGCCCAATGAGACATCTAGGGAGTCCATACACATCAGTGAGCAGATG
TAGTTTGCTTATTTATAGCATGTTTCTTTTTGAAAAACTAGTGGTGGACACATTTGGATCACATTTATACAGTTATAAAAATAAAGGTTT
GATTTTGGTCGTTCTTCAGATGTTTGGCTCTGAATGACTTAAGCTGAAGTAACTGGCTCCTTACTTTAAATGTTCTGCCATCATTTCACC
TGATGAGCATTCTTGGAGCCTGCCAGATATTGTTAGGTCCTGGGGCTGCAAAGAGGTCCTCAACAGGATGTAAAGCAAACTTAATTGTAA
TTAATTTATTCAGCCCATTAAGAAAGTACTAAAGTTTTATCTCTGTAGTTCCTCAAATTGGCATCTGGTAATGTACATTGTGAGGTAGAC
TGATAATGAAATGACAGTGTAACATCTTAACCAAGAAGTAAATATGACCTCAGTGTCCTATAAATAATGTAAGAGCAGGATTTGAAACTT
GGAGAGCTGTTTTCTCATTTCATGTACACTTGCCCCAAATTGTCTTTGAAGTCGTGTGCATTGCACGTTGGATGAGCCAGGGAAATTATT
ACATTAACAAGCATTTTGTGTGTACGTAGTAGTTACTTTGTACTGAGAGAACTTGCTTTGGGGTGCAATTAATAAACTGATTTTATTTGG
GAGAAACAAGGAAGGGTGCACTTAACTAGCAACCTAAGCATGATTTTTCAGCTTTTGCCCTTAGGGTTTAAATTACAATTCCAAAATGTT
AGACATACTGTATTTTTTCGTTCAGTGTGGCTTTAATTTTCCCCTCTTGCAGTTTGTTCTGTAATGCCTTTTACATTTGGACACATAGTT
TATGCTTTTTAGATTTTGGTTGCTTTCTTGCCAAAATAAGTGTTAACTGTGTTTCAAACTTGATTTTCTTTCCTTTTTCTTTTTTTTTTC
TTCCAGAATGTCTTATTTAAAAAGAAAGCTAAAAGCATACTTCTAAGTCAGAGCCTCTATTTTGGTGTAAGACTTGGGATATTTTTTACT
TCACATTGAATATAGCCAGGCACCCAAGAAGTCTGATGGCCACCTGAGTGCAGGTGACAAGGACCTGACAGAGCCCATGCAGGGCTTTAG
ATTTGGACACACAAGAGTTGATAACTTCCTCATGAACTCCTTGCCTGATCTAAACTCATATTATGGGTTCTGACTGTTTGAGTAATCATC
TTCAAGGTTAAACCTCTTGGCAGTTACCCTTTTCACAAAGTGCACAGTGGGAATCGAGAATCGATAGGGTTAATTTTGGAGCAGTGGCTT
ATACCATTCACCTCTGTTTTTTTGTGATTATTTCACAGATAATGAGACCTTAATAACAAATAGGCGTAAAAAAATTTTCACATTGAAATG
ATAGAAACATTTGATGTAATAAAACTTGGTTGGCTTGATATTTTAAGGAATTGAAACCTAGCAATCTTATTGGAGAGACAAGAATTGGTC
TCCAGCTGCCTTTGATCAAGATTCGGGTGCAAGTGGAGCAGGAGCCATATACCTGGAGGGAATGTGCTTTGTCACACCAAAGAGGATTTT
TTTTTCTTCAAACTTGTATGTTGCCTAGGTTTCAAATTCTTTGCCGCAAGGCTGATCTGCTTTCATTAACTGGAATTCTGTAGGAGATAC
TGGTGACCTAAGCTAAGTTGCACTCAGCATACTCAGTGTCAAGCTAATGAGGTTCTATTATAAAGGTTCTACTTTTAATCTGAGGGAAAA
CATGTTCAGGGCTTCTAGAACACTAAAAAATTTGGCTTAAACCAGTGTTCAGTCTGGTGCCAAACTTCGAATGGAATACAAATTCACATA
ATCTGAACTTTGTTCACAGGTTATCCTAATAGAGTAATTCTTCACTTTGCTCTATTGAACTGTCTTAAGGATTTGTTTAAACAGCTAAGT
TACTTGATTAAAATAATGATAAAATTGTATTTTGTCTTTGCTTTAATATTAAAGTTAACAAGTTTTCATTTTATAATGAGATCAAAGCAT
TGGAATCTGCCCTGTTTTGTAGCCGTTGCTTTGGATTTGTGTTGGATGTATCCTGCAGTTACACTTGCCAGCCCCACTCACAAAAGTTGT
TCATTTCATTGGGTCACTGGCTTTATTTGCTAGTCTTGTCTGTGAACTGAGCATCTGCCTCAGTTTTATTACTTGAAATCTTGGCAGGTG
CTTAATAGGGAACATACATACAGCTATGTAACTGTGAATAATTGTATATATCTCTAGTTAAGAATGAGGGAATGGGGAGGTTTGCTTTCT
AAACAAGTGCATTCTGAAATTGACTTAAAAATTTTTAGTGTGGGTCCTAAAGTTTAGAGATGGGCAAGGAGGTCTCTAATCCACCGCTTC
CCGCTTGAGAAGGGAGGGGTATCAAAATTGAGCCCCAAGCTGTTTGTTCCAGTGTACCAAGCACTGACTTTATGCCTTTGGCCTGGAGAT
GGCAGAAGTGAAAGCTGGCCATCTGCAAAAAGCAGATAAGTGAGTTTGAACCTTTTGCATTTTGTTAGCTCAGTCAGTCCTCATCGTGGT
CCTGAGGCATAGGTACTGTTGTACCAAGGTCACTTATCTAACAAAATAACCCTTCATGTATTTTAAATTTATTTGACAAGTCTGCAGACA
ATCCTTATCTAACCAGCTATTTTCTTAATTGCTACAGCTTGACCTACCAGTATTCCGGAGTAACCAGCAAATGCAAAGTTGACCTTGTTC
CTGCATCATCTTTTTGATGGTTCAAATTTCAGCCTCCCTGACTACTACAAAGCCAGAGCAGTCTTAGTACCAGAAACAGTGTTGCACTTT
CGTTGCATGTGCTGTGTGACCCCAAGGGGACAGGGAGTCACTTTGGTCATCTCTGTCCCCAGTACAGATCTTGATTCATAGTGACATTCC
ATAAGTGGGGTGACAGCAAATGACTTGCAGGTAGTCTCATTGTAGGTTTGTGCACCAGAGTGACCCTGTGAGCCTTTGTTAATAGGTTGG
GAGCTCAGGGTGTTTATGTCCACCTGTCTGGTCTAGCCAAACAGTTTTTTTCTGGGAATCAAATTTCTGTGGTTTTTATGGCCAGAAATT
TTAAGGACTTGTGTGTGCTGGGATATGAGAATAGAAGCTACAGAGTTCTTTTCTTGGGACCTAGACTGGGAGGTGCAATGTCAGGACCTC
CAGGTGAATGGTAGGATCTGAGTTGACCCTGCAGTTCGGTTATGCAGTCAATTATTTCTTTTTAAGAGGAGGAGGATTCACTTGGGTGTT
GGGATCAAATTTGGATTCTGTCCCAGGCCTTACTGTAAAACTAGGGGATTGCCTTTCCATATCTGCTGGGGGTGGAGACCCTTATGTGCA
GCACTCAATCCCACTGGAAGCCTAATGCTGCAGTCAGAAGCAATGCCTGGCTGGGGCAGTAGGGGAAATTCCACCCAATTTTGCTATGAG
CCTAAAACCTCTTTAAAAACGGTCAGTTAACTAAAAAATAAAAATCAAGTCTTTAGGAGAGTAGAAAACACAATTAACTAAAAAGCAGGG
ACATCTGAAAGAGACGTATTAAGTTAACATTTTTAAAAATCCAAATGAAAGTAAATGGAATAAATGTATCAGGTAAAGGACAAGTTGTAA
GCTTGGATTTTTAGGTCTAGCAATACACTGTTTACAAGAGCATCACCTAAAATGTGACAAAAGATGTTGAAAGGATGAAAAAAGGTATAG

>102375_102375_1_ZNF562-EIF5_ZNF562_chr19_9771395_ENST00000448622_EIF5_chr14_103803013_ENST00000216554_length(amino acids)=388AA_BP=8
MSAFDMSHDPTKYFGCELGAQTQFDVKNDRYIVNGSHEANKLQDMLDGFIKKFVLCPECENPETDLHVNPKKQTIGNSCKACGYRGMLDT
HHKLCTFILKNPPENSDSGTGKKEKEKKNRKGKDKENGSVSSSETPPPPPPPNEINPPPHTMEEEEDDDWGEDTTEEAQRRRMDEISDHA
KVLTLSDDLERTIEERVNILFDFVKKKKEEGVIDSSDKEIVAEAERLDVKAMGPLVLTEVLFNEKIREQIKKYRRHFLRFCHNNKKAQRY
LLHGLECVVAMHQAQLISKIPHILKEMYDADLLEEEVIISWSEKASKKYVSKELAKEIRVKAEPFIKWLKEAEEESSGGEEEDEDENIEV

--------------------------------------------------------------
>102375_102375_2_ZNF562-EIF5_ZNF562_chr19_9771395_ENST00000448622_EIF5_chr14_103803013_ENST00000558506_length(transcript)=3506nt_BP=188nt
AGTGTGCCACCGCCATCTTTACCGGCTGTGGCTCAGCATGGTCAGTGCCGTTTAACCTTTATTGTGGTGGAGTCCACCCCGCTGTGATTC
ATAAGCTGCCCTGAGGCGATCTTGGCATCAAGAAAGACAGCATTGAGGCACATCTCACCATCAGCTTCAGAGGATGTCAGCCTTTGATAT
GTCCCATGATCCCACCAAATATTTTGGTTGTGAGCTGGGAGCACAGACCCAGTTTGATGTTAAGAATGACCGTTACATTGTCAATGGATC
TCATGAGGCGAATAAGCTGCAAGACATGTTGGATGGATTCATTAAAAAATTTGTTCTCTGTCCTGAATGTGAGAATCCTGAAACAGATTT
GCATGTCAATCCAAAGAAGCAAACAATAGGTAATTCTTGTAAAGCCTGTGGCTATCGAGGCATGCTTGACACACATCATAAACTCTGCAC
ATTCATTCTCAAAAACCCACCTGAGAATAGTGACAGTGGTACAGGAAAGAAAGAAAAAGAAAAGAAAAACAGAAAGGGCAAAGACAAGGA
AAATGGCTCCGTATCCAGCAGTGAGACACCACCACCACCACCACCACCAAATGAAATTAATCCTCCTCCACATACAATGGAAGAAGAGGA
GGATGATGACTGGGGAGAAGATACAACTGAGGAAGCTCAAAGGCGTCGAATGGATGAAATCAGTGACCATGCAAAAGTTCTGACACTCAG
TGATGATTTGGAAAGAACAATTGAGGAGAGGGTCAATATCCTCTTTGATTTTGTTAAGAAAAAGAAAGAAGAGGGTGTTATTGATTCATC
TGACAAAGAAATCGTTGCTGAAGCAGAAAGACTGGATGTAAAAGCCATGGGCCCTCTTGTTCTAACTGAAGTTCTTTTTAATGAGAAGAT
TAGAGAACAGATTAAGAAATACAGGCGCCATTTCCTACGATTTTGTCACAACAACAAAAAAGCCCAACGGTACCTTCTTCATGGTTTGGA
GTGTGTGGTAGCAATGCATCAAGCTCAGCTTATCTCCAAGATTCCACATATCTTGAAGGAGATGTACGATGCAGACCTTTTAGAAGAAGA
GGTCATCATCAGCTGGTCGGAAAAGGCCTCTAAGAAATATGTCTCCAAAGAACTTGCCAAAGAGATTCGTGTCAAAGCAGAACCATTTAT
AAAATGGTTGAAGGAGGCAGAGGAAGAATCTTCTGGTGGCGAAGAAGAAGATGAAGATGAGAACATTGAGGTGGTGTATTCGAAGGCTGC
CAGTGTACCGAAAGTTGAGACTGTAAAGTCAGACAACAAGGATGACGACATCGATATTGATGCCATTTAAAGGGATGGATGCAACCTAGC
TTAACAGTATAATGCTGCAAATTTTCCTCCATTATCAGCCAGAAGTGCAACATGTATGTGCAAAAGCTAAAATGGCTTAACATCATGCTA
CACTTTACACTAAAAATCTATTACTGTGAGTGGTCTGTTATTAAGCCCAATGAGACATCTAGGGAGTCCATACACATCAGTGAGCAGATG
TAGTTTGCTTATTTATAGCATGTTTCTTTTTGAAAAACTAGTGGTGGACACATTTGGATCACATTTATACAGTTATAAAAATAAAGGTTT
GATTTTGGTCGTTCTTCAGATGTTTGGCTCTGAATGACTTAAGCTGAAGTAACTGGCTCCTTACTTTAAATGTTCTGCCATCATTTCACC
TGATGAGCATTCTTGGAGCCTGCCAGATATTGTTAGGTCCTGGGGCTGCAAAGAGGTCCTCAACAGGATGTAAAGCAAACTTAATTGTAA
TTAATTTATTCAGCCCATTAAGAAAGTACTAAAGTTTTATCTCTGTAGTTCCTCAAATTGGCATCTGGTAATGTACATTGTGAGGTAGAC
TGATAATGAAATGACAGTGTAACATCTTAACCAAGAAGTAAATATGACCTCAGTGTCCTATAAATAATGTAAGAGCAGGATTTGAAACTT
GGAGAGCTGTTTTCTCATTTCATGTACACTTGCCCCAAATTGTCTTTGAAGTCGTGTGCATTGCACGTTGGATGAGCCAGGGAAATTATT
ACATTAACAAGCATTTTGTGTGTACGTAGTAGTTACTTTGTACTGAGAGAACTTGCTTTGGGGTGCAATTAATAAACTGATTTTATTTGG
GAGAAACAAGGAAGGGTGCACTTAACTAGCAACCTAAGCATGATTTTTCAGCTTTTGCCCTTAGGGTTTAAATTACAATTCCAAAATGTT
AGACATACTGTATTTTTTCGTTCAGTGTGGCTTTAATTTTCCCCTCTTGCAGTTTGTTCTGTAATGCCTTTTACATTTGGACACATAGTT
TATGCTTTTTAGATTTTGGTTGCTTTCTTGCCAAAATAAGTGTTAACTGTGTTTCAAACTTGATTTTCTTTCCTTTTTCTTTTTTTTTTC
TTCCAGAATGTCTTATTTAAAAAGAAAGCTAAAAGCATACTTCTAAGTCAGAGCCTCTATTTTGGTGTAAGACTTGGGATATTTTTTACT
TCACATTGAATATAGCCAGGCACCCAAGAAGTCTGATGGCCACCTGAGTGCAGGTGACAAGGACCTGACAGAGCCCATGCAGGGCTTTAG
ATTTGGACACACAAGAGTTGATAACTTCCTCATGAACTCCTTGCCTGATCTAAACTCATATTATGGGTTCTGACTGTTTGAGTAATCATC
TTCAAGGTTAAACCTCTTGGCAGTTACCCTTTTCACAAAGTGCACAGTGGGAATCGAGAATCGATAGGGTTAATTTTGGAGCAGTGGCTT
ATACCATTCACCTCTGTTTTTTTGTGATTATTTCACAGATAATGAGACCTTAATAACAAATAGGCGTAAAAAAATTTTCACATTGAAATG
ATAGAAACATTTGATGTAATAAAACTTGGTTGGCTTGATATTTTAAGGAATTGAAACCTAGCAATCTTATTGGAGAGACAAGAATTGGTC
TCCAGCTGCCTTTGATCAAGATTCGGGTGCAAGTGGAGCAGGAGCCATATACCTGGAGGGAATGTGCTTTGTCACACCAAAGAGGATTTT
TTTTTCTTCAAACTTGTATGTTGCCTAGGTTTCAAATTCTTTGCCGCAAGGCTGATCTGCTTTCATTAACTGGAATTCTGTAGGAGATAC
TGGTGACCTAAGCTAAGTTGCACTCAGCATACTCAGTGTCAAGCTAATGAGGTTCTATTATAAAGGTTCTACTTTTAATCTGAGGGAAAA
CATGTTCAGGGCTTCTAGAACACTAAAAAATTTGGCTTAAACCAGTGTTCAGTCTGGTGCCAAACTTCGAATGGAATACAAATTCACATA
ATCTGAACTTTGTTCACAGGTTATCCTAATAGAGTAATTCTTCACTTTGCTCTATTGAACTGTCTTAAGGATTTGTTTAAACAGCTAAGT

>102375_102375_2_ZNF562-EIF5_ZNF562_chr19_9771395_ENST00000448622_EIF5_chr14_103803013_ENST00000558506_length(amino acids)=388AA_BP=8
MSAFDMSHDPTKYFGCELGAQTQFDVKNDRYIVNGSHEANKLQDMLDGFIKKFVLCPECENPETDLHVNPKKQTIGNSCKACGYRGMLDT
HHKLCTFILKNPPENSDSGTGKKEKEKKNRKGKDKENGSVSSSETPPPPPPPNEINPPPHTMEEEEDDDWGEDTTEEAQRRRMDEISDHA
KVLTLSDDLERTIEERVNILFDFVKKKKEEGVIDSSDKEIVAEAERLDVKAMGPLVLTEVLFNEKIREQIKKYRRHFLRFCHNNKKAQRY
LLHGLECVVAMHQAQLISKIPHILKEMYDADLLEEEVIISWSEKASKKYVSKELAKEIRVKAEPFIKWLKEAEEESSGGEEEDEDENIEV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZNF562-EIF5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF562-EIF5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF562-EIF5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource