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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Diseases

Fusion gene:ZNF569-PRRC2C (FusionGDB2 ID:102411)

Fusion Gene Summary for ZNF569-PRRC2C

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF569-PRRC2C
Fusion gene ID: 102411
HgeneTgene
Gene symbol

ZNF569

PRRC2C

Gene ID

148266

23215

Gene namezinc finger protein 569proline rich coiled-coil 2C
SynonymsZAP1|ZNF|Zfp74BAT2-iso|BAT2D1|BAT2L2|XTP2
Cytomap

19q13.12

1q24.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 569DNA-binding proteinprotein PRRC2CBAT2 domain containing 1BAT2 domain-containing protein 1HBV X-transactivated gene 2 proteinHBV XAg-transactivated protein 2HBxAg transactivated protein 2HLA-B-associated transcript 2-like 2proline-rich and coiled-coil-containing prote
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000316950, ENST00000392149, 
ENST00000589833, ENST00000592490, 
ENST00000392150, ENST00000591073, 
ENST00000338920, ENST00000367742, 
ENST00000476522, ENST00000392078, 
ENST00000426496, 
Fusion gene scores* DoF score4 X 2 X 2=1619 X 25 X 7=3325
# samples 325
** MAII scorelog2(3/16*10)=0.906890595608518
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(25/3325*10)=-3.73335434061383
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF569 [Title/Abstract] AND PRRC2C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF569(37935809)-PRRC2C(171544066), # samples:1
Anticipated loss of major functional domain due to fusion event.ZNF569-PRRC2C seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ZNF569-PRRC2C seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ZNF569 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PRRC2C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-EW-A1PH-01AZNF569chr19

37935809

-PRRC2Cchr1

171544066

+


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Fusion Gene ORF analysis for ZNF569-PRRC2C

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000316950ENST00000338920ZNF569chr19

37935809

-PRRC2Cchr1

171544066

+
5CDS-intronENST00000316950ENST00000367742ZNF569chr19

37935809

-PRRC2Cchr1

171544066

+
5CDS-intronENST00000316950ENST00000476522ZNF569chr19

37935809

-PRRC2Cchr1

171544066

+
5CDS-intronENST00000392149ENST00000338920ZNF569chr19

37935809

-PRRC2Cchr1

171544066

+
5CDS-intronENST00000392149ENST00000367742ZNF569chr19

37935809

-PRRC2Cchr1

171544066

+
5CDS-intronENST00000392149ENST00000476522ZNF569chr19

37935809

-PRRC2Cchr1

171544066

+
5CDS-intronENST00000589833ENST00000338920ZNF569chr19

37935809

-PRRC2Cchr1

171544066

+
5CDS-intronENST00000589833ENST00000367742ZNF569chr19

37935809

-PRRC2Cchr1

171544066

+
5CDS-intronENST00000589833ENST00000476522ZNF569chr19

37935809

-PRRC2Cchr1

171544066

+
5CDS-intronENST00000592490ENST00000338920ZNF569chr19

37935809

-PRRC2Cchr1

171544066

+
5CDS-intronENST00000592490ENST00000367742ZNF569chr19

37935809

-PRRC2Cchr1

171544066

+
5CDS-intronENST00000592490ENST00000476522ZNF569chr19

37935809

-PRRC2Cchr1

171544066

+
5UTR-3CDSENST00000392150ENST00000392078ZNF569chr19

37935809

-PRRC2Cchr1

171544066

+
5UTR-3CDSENST00000392150ENST00000426496ZNF569chr19

37935809

-PRRC2Cchr1

171544066

+
5UTR-3CDSENST00000591073ENST00000392078ZNF569chr19

37935809

-PRRC2Cchr1

171544066

+
5UTR-3CDSENST00000591073ENST00000426496ZNF569chr19

37935809

-PRRC2Cchr1

171544066

+
5UTR-intronENST00000392150ENST00000338920ZNF569chr19

37935809

-PRRC2Cchr1

171544066

+
5UTR-intronENST00000392150ENST00000367742ZNF569chr19

37935809

-PRRC2Cchr1

171544066

+
5UTR-intronENST00000392150ENST00000476522ZNF569chr19

37935809

-PRRC2Cchr1

171544066

+
5UTR-intronENST00000591073ENST00000338920ZNF569chr19

37935809

-PRRC2Cchr1

171544066

+
5UTR-intronENST00000591073ENST00000367742ZNF569chr19

37935809

-PRRC2Cchr1

171544066

+
5UTR-intronENST00000591073ENST00000476522ZNF569chr19

37935809

-PRRC2Cchr1

171544066

+
Frame-shiftENST00000316950ENST00000392078ZNF569chr19

37935809

-PRRC2Cchr1

171544066

+
Frame-shiftENST00000316950ENST00000426496ZNF569chr19

37935809

-PRRC2Cchr1

171544066

+
Frame-shiftENST00000592490ENST00000392078ZNF569chr19

37935809

-PRRC2Cchr1

171544066

+
Frame-shiftENST00000592490ENST00000426496ZNF569chr19

37935809

-PRRC2Cchr1

171544066

+
In-frameENST00000392149ENST00000392078ZNF569chr19

37935809

-PRRC2Cchr1

171544066

+
In-frameENST00000392149ENST00000426496ZNF569chr19

37935809

-PRRC2Cchr1

171544066

+
In-frameENST00000589833ENST00000392078ZNF569chr19

37935809

-PRRC2Cchr1

171544066

+
In-frameENST00000589833ENST00000426496ZNF569chr19

37935809

-PRRC2Cchr1

171544066

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000392149ZNF569chr1937935809-ENST00000426496PRRC2Cchr1171544066+19082011261907593
ENST00000392149ZNF569chr1937935809-ENST00000392078PRRC2Cchr1171544066+21452011262144672
ENST00000589833ZNF569chr1937935809-ENST00000426496PRRC2Cchr1171544066+20073001232006627
ENST00000589833ZNF569chr1937935809-ENST00000392078PRRC2Cchr1171544066+22443001232243706

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000392149ENST00000426496ZNF569chr1937935809-PRRC2Cchr1171544066+0.0269325260.9730674
ENST00000392149ENST00000392078ZNF569chr1937935809-PRRC2Cchr1171544066+0.0291804690.97081953
ENST00000589833ENST00000426496ZNF569chr1937935809-PRRC2Cchr1171544066+0.0182882230.98171175
ENST00000589833ENST00000392078ZNF569chr1937935809-PRRC2Cchr1171544066+0.0215818680.9784182

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Fusion Genomic Features for ZNF569-PRRC2C


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ZNF569chr1937935808-PRRC2Cchr1171544065+9.74E-080.9999999
ZNF569chr1937935808-PRRC2Cchr1171544065+9.74E-080.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ZNF569-PRRC2C


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:37935809/chr1:171544066)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePRRC2Cchr19:37935809chr1:171544066ENST0000033892023342345_263422492818.0Compositional biasNote=Gln-rich
TgenePRRC2Cchr19:37935809chr1:171544066ENST0000039207823352345_263422512899.0Compositional biasNote=Gln-rich
TgenePRRC2Cchr19:37935809chr1:171544066ENST0000042649621322345_263421842753.0Compositional biasNote=Gln-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF569chr19:37935809chr1:171544066ENST00000316950-368_795687.0DomainKRAB
HgeneZNF569chr19:37935809chr1:171544066ENST00000392149-258_795687.0DomainKRAB
HgeneZNF569chr19:37935809chr1:171544066ENST00000316950-36186_2085687.0Zinc fingerC2H2-type 1
HgeneZNF569chr19:37935809chr1:171544066ENST00000316950-36214_2365687.0Zinc fingerC2H2-type 2
HgeneZNF569chr19:37935809chr1:171544066ENST00000316950-36242_2645687.0Zinc fingerC2H2-type 3
HgeneZNF569chr19:37935809chr1:171544066ENST00000316950-36270_2925687.0Zinc fingerC2H2-type 4
HgeneZNF569chr19:37935809chr1:171544066ENST00000316950-36298_3205687.0Zinc fingerC2H2-type 5
HgeneZNF569chr19:37935809chr1:171544066ENST00000316950-36326_3485687.0Zinc fingerC2H2-type 6
HgeneZNF569chr19:37935809chr1:171544066ENST00000316950-36354_3765687.0Zinc fingerC2H2-type 7
HgeneZNF569chr19:37935809chr1:171544066ENST00000316950-36382_4045687.0Zinc fingerC2H2-type 8
HgeneZNF569chr19:37935809chr1:171544066ENST00000316950-36410_4325687.0Zinc fingerC2H2-type 9
HgeneZNF569chr19:37935809chr1:171544066ENST00000316950-36438_4605687.0Zinc fingerC2H2-type 10
HgeneZNF569chr19:37935809chr1:171544066ENST00000316950-36466_4885687.0Zinc fingerC2H2-type 11
HgeneZNF569chr19:37935809chr1:171544066ENST00000316950-36494_5165687.0Zinc fingerC2H2-type 12
HgeneZNF569chr19:37935809chr1:171544066ENST00000316950-36522_5445687.0Zinc fingerC2H2-type 13
HgeneZNF569chr19:37935809chr1:171544066ENST00000316950-36550_5725687.0Zinc fingerC2H2-type 14
HgeneZNF569chr19:37935809chr1:171544066ENST00000316950-36578_6005687.0Zinc fingerC2H2-type 15
HgeneZNF569chr19:37935809chr1:171544066ENST00000316950-36606_6285687.0Zinc fingerC2H2-type 16
HgeneZNF569chr19:37935809chr1:171544066ENST00000316950-36634_6565687.0Zinc fingerC2H2-type 17
HgeneZNF569chr19:37935809chr1:171544066ENST00000316950-36662_6845687.0Zinc fingerC2H2-type 18
HgeneZNF569chr19:37935809chr1:171544066ENST00000392149-25186_2085687.0Zinc fingerC2H2-type 1
HgeneZNF569chr19:37935809chr1:171544066ENST00000392149-25214_2365687.0Zinc fingerC2H2-type 2
HgeneZNF569chr19:37935809chr1:171544066ENST00000392149-25242_2645687.0Zinc fingerC2H2-type 3
HgeneZNF569chr19:37935809chr1:171544066ENST00000392149-25270_2925687.0Zinc fingerC2H2-type 4
HgeneZNF569chr19:37935809chr1:171544066ENST00000392149-25298_3205687.0Zinc fingerC2H2-type 5
HgeneZNF569chr19:37935809chr1:171544066ENST00000392149-25326_3485687.0Zinc fingerC2H2-type 6
HgeneZNF569chr19:37935809chr1:171544066ENST00000392149-25354_3765687.0Zinc fingerC2H2-type 7
HgeneZNF569chr19:37935809chr1:171544066ENST00000392149-25382_4045687.0Zinc fingerC2H2-type 8
HgeneZNF569chr19:37935809chr1:171544066ENST00000392149-25410_4325687.0Zinc fingerC2H2-type 9
HgeneZNF569chr19:37935809chr1:171544066ENST00000392149-25438_4605687.0Zinc fingerC2H2-type 10
HgeneZNF569chr19:37935809chr1:171544066ENST00000392149-25466_4885687.0Zinc fingerC2H2-type 11
HgeneZNF569chr19:37935809chr1:171544066ENST00000392149-25494_5165687.0Zinc fingerC2H2-type 12
HgeneZNF569chr19:37935809chr1:171544066ENST00000392149-25522_5445687.0Zinc fingerC2H2-type 13
HgeneZNF569chr19:37935809chr1:171544066ENST00000392149-25550_5725687.0Zinc fingerC2H2-type 14
HgeneZNF569chr19:37935809chr1:171544066ENST00000392149-25578_6005687.0Zinc fingerC2H2-type 15
HgeneZNF569chr19:37935809chr1:171544066ENST00000392149-25606_6285687.0Zinc fingerC2H2-type 16
HgeneZNF569chr19:37935809chr1:171544066ENST00000392149-25634_6565687.0Zinc fingerC2H2-type 17
HgeneZNF569chr19:37935809chr1:171544066ENST00000392149-25662_6845687.0Zinc fingerC2H2-type 18
TgenePRRC2Cchr19:37935809chr1:171544066ENST0000033892023341020_104622492818.0Coiled coilOntology_term=ECO:0000255
TgenePRRC2Cchr19:37935809chr1:171544066ENST0000033892023341682_171722492818.0Coiled coilOntology_term=ECO:0000255
TgenePRRC2Cchr19:37935809chr1:171544066ENST0000039207823351020_104622512899.0Coiled coilOntology_term=ECO:0000255
TgenePRRC2Cchr19:37935809chr1:171544066ENST0000039207823351682_171722512899.0Coiled coilOntology_term=ECO:0000255
TgenePRRC2Cchr19:37935809chr1:171544066ENST0000042649621321020_104621842753.0Coiled coilOntology_term=ECO:0000255
TgenePRRC2Cchr19:37935809chr1:171544066ENST0000042649621321682_171721842753.0Coiled coilOntology_term=ECO:0000255
TgenePRRC2Cchr19:37935809chr1:171544066ENST0000033892023341059_108222492818.0Compositional biasNote=Pro-rich
TgenePRRC2Cchr19:37935809chr1:171544066ENST0000033892023341341_144322492818.0Compositional biasNote=Arg-rich
TgenePRRC2Cchr19:37935809chr1:171544066ENST0000033892023341760_193422492818.0Compositional biasNote=Ala-rich
TgenePRRC2Cchr19:37935809chr1:171544066ENST000003389202334407_41022492818.0Compositional biasNote=Poly-Pro
TgenePRRC2Cchr19:37935809chr1:171544066ENST000003389202334467_65022492818.0Compositional biasNote=Glu-rich
TgenePRRC2Cchr19:37935809chr1:171544066ENST000003389202334666_70322492818.0Compositional biasNote=Gln-rich
TgenePRRC2Cchr19:37935809chr1:171544066ENST000003389202334697_76922492818.0Compositional biasNote=Pro-rich
TgenePRRC2Cchr19:37935809chr1:171544066ENST0000039207823351059_108222512899.0Compositional biasNote=Pro-rich
TgenePRRC2Cchr19:37935809chr1:171544066ENST0000039207823351341_144322512899.0Compositional biasNote=Arg-rich
TgenePRRC2Cchr19:37935809chr1:171544066ENST0000039207823351760_193422512899.0Compositional biasNote=Ala-rich
TgenePRRC2Cchr19:37935809chr1:171544066ENST000003920782335407_41022512899.0Compositional biasNote=Poly-Pro
TgenePRRC2Cchr19:37935809chr1:171544066ENST000003920782335467_65022512899.0Compositional biasNote=Glu-rich
TgenePRRC2Cchr19:37935809chr1:171544066ENST000003920782335666_70322512899.0Compositional biasNote=Gln-rich
TgenePRRC2Cchr19:37935809chr1:171544066ENST000003920782335697_76922512899.0Compositional biasNote=Pro-rich
TgenePRRC2Cchr19:37935809chr1:171544066ENST0000042649621321059_108221842753.0Compositional biasNote=Pro-rich
TgenePRRC2Cchr19:37935809chr1:171544066ENST0000042649621321341_144321842753.0Compositional biasNote=Arg-rich
TgenePRRC2Cchr19:37935809chr1:171544066ENST0000042649621321760_193421842753.0Compositional biasNote=Ala-rich
TgenePRRC2Cchr19:37935809chr1:171544066ENST000004264962132407_41021842753.0Compositional biasNote=Poly-Pro
TgenePRRC2Cchr19:37935809chr1:171544066ENST000004264962132467_65021842753.0Compositional biasNote=Glu-rich
TgenePRRC2Cchr19:37935809chr1:171544066ENST000004264962132666_70321842753.0Compositional biasNote=Gln-rich
TgenePRRC2Cchr19:37935809chr1:171544066ENST000004264962132697_76921842753.0Compositional biasNote=Pro-rich


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Fusion Gene Sequence for ZNF569-PRRC2C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>102411_102411_1_ZNF569-PRRC2C_ZNF569_chr19_37935809_ENST00000392149_PRRC2C_chr1_171544066_ENST00000392078_length(transcript)=2145nt_BP=201nt
GCCCCTGGTGTAACGGACCGAGACTTGTGGCGCTCTCAGCCACCGACAGCGCCGGCCTCAGTGCCGCCTCTGTCCCAGCCCGCGCCGGCT
CTGCCACTTTGGCAGCGTTAAGTGTGGAATCGGGGCCTGTGTCCGCGGGCTTGCTCTACTTCTGCAGGCCCCATCCCTTCCCAGAAAGAA
GAGGAAATGACTGAGTCCCAGATGGAGTCTGCACGCAAAGCATGGGAGAATTCTCCAAATGTAAGGGAAAAGGGGTCTCCAGTAACTTCC
ACAGCACCTCCAATTGCAACTGGAGTCAGCAGTAGTGCCAGTGGACCAAGCACTGCTAATTACAATTCGTTCTCAAGTGCATCCATGCCC
CAGATTCCTGTTGCTTCAGTCACTCCTACAGCATCACTATCAGGAGCTGGTACATACACTACCTCTTCTTTGAGCACAAAATCTACAACC
ACATCGGACCCTCCAAATATTTGTAAAGTGAAACCTCAGCAGTTACAGACAAGCAGCCTGCCTTCTGCAAGTCATTTTTCACAGTTAAGC
TGTATGCCTTCCCTTATTGCCCAGCAGCAACAGAATCCGCAAGTTTATGTGTCTCAGTCTGCAGCAGCTCAAATCCCAGCCTTCTATATG
GACACAAGTCATTTATTCAATACCCAACATGCACGATTGGCTCCGCCATCCTTGGCTCAACAACAGGGTTTCCAACCAGGTCTCTCTCAG
CCAACTTCAGTTCAGCAGATTCCAATCCCTATTTATGCACCACTGCAAGGGCAGCATCAAGCCCAACTGAGTTTGGGGGCTGGCCCTGCT
GTTTCCCAGGCTCAGGAATTGTTCAGCTCCTCACTTCAACCATATAGATCTCAGCCAGCTTTTATGCAAAGCAGTTTATCCCAGCCATCT
GTGGTCCTTTCTGGTACTGCTATTCACAACTTTCCAACTGTCCAACACCAAGAACTTGCCAAGGCACAATCCGGTCTTGCCTTTCAGCAA
ACATCAAATACTCAGCCCATTCCTATATTGTATGAACATCAACTGGGGCAGGCATCAGGACTAGGAGGTTCCCAGCTGATTGACACACAT
CTTCTCCAGGCCAGAGCAAATCTTACCCAGGCCTCAAATCTTTATTCTGGACAAGTACAACAGCCTGGTCAGACAAATTTTTATAACACT
GCCCAGTCACCAAGTGCTCTCCAGCAGGTTACAGTACCTTTACCAGCATCGCAGCTTTCCTTGCCTAATTTTGGATCTACAGGGCAACCT
CTAATTGCTTTGCCTCAGACTCTTCAGCCCCCATTACAGCATACCACTCCCCAAGCACAGGCTCAGAGTCTGAGTCGTCCTGCACAAGTA
AGCCAGCCTTTCAGAGGATTAATTCCTGCTGGAACACAGCATAGCATGATTGCAACCACAGGAAAAATGTCTGAAATGGAACTAAAAGCC
TTTGGAAGTGGCATTGATATAAAACCAGGCACACCTCCAATCGCTGGTAGAAGCACCACACCAACATCTAGTCCCTTCCGGGCTACTTCT
ACAAGTCCGAACAGCCAGTCCAGCAAAATGAACAGCATTGTCTACCAGAAGCAGTTCCAGTCAGCCCCTGCCACTGTGAGAATGACACAA
CCATTTCCTACACAGTTTGCACCCCAGATTCTCTCCCAGCCTAACCTGGTCCCTCCATTGGTAAGAGCCCCACATACTAACACCTTCCCA
GCGCCTGTTCAGAGGCCACCAATGGCACTGGCCAGTCAGATGCCTCCTCCGCTGACCACAGGCCTCATGAGCCATGCTCGTTTGCCACAT
GTAGCCAGGGGTCCTTGTGGATCACTATCTGGAGTCAGAGGTAATCAGGCCCAGGCTGCGTTGAAGGCTGAACAAGACATGAAGGCAAAG
CAGAGAGCAGAGGTTCTTCAGTCCACGCAACGGTTCTTCTCTGAACAGCAACAGAGCAAACAGATAGGAGGAGGCAAAGCCCAGAAAGTG
GACAGTGATTCAAGTAAACCTCCTGAAACACTGACCGACCCTCCTGGGGTCTGTCAGGAAAAAGTAGAAGAAAAGCCACCCCCTGCACCC

>102411_102411_1_ZNF569-PRRC2C_ZNF569_chr19_37935809_ENST00000392149_PRRC2C_chr1_171544066_ENST00000392078_length(amino acids)=672AA_BP=24
MCPRACSTSAGPIPSQKEEEMTESQMESARKAWENSPNVREKGSPVTSTAPPIATGVSSSASGPSTANYNSFSSASMPQIPVASVTPTAS
LSGAGTYTTSSLSTKSTTTSDPPNICKVKPQQLQTSSLPSASHFSQLSCMPSLIAQQQQNPQVYVSQSAAAQIPAFYMDTSHLFNTQHAR
LAPPSLAQQQGFQPGLSQPTSVQQIPIPIYAPLQGQHQAQLSLGAGPAVSQAQELFSSSLQPYRSQPAFMQSSLSQPSVVLSGTAIHNFP
TVQHQELAKAQSGLAFQQTSNTQPIPILYEHQLGQASGLGGSQLIDTHLLQARANLTQASNLYSGQVQQPGQTNFYNTAQSPSALQQVTV
PLPASQLSLPNFGSTGQPLIALPQTLQPPLQHTTPQAQAQSLSRPAQVSQPFRGLIPAGTQHSMIATTGKMSEMELKAFGSGIDIKPGTP
PIAGRSTTPTSSPFRATSTSPNSQSSKMNSIVYQKQFQSAPATVRMTQPFPTQFAPQILSQPNLVPPLVRAPHTNTFPAPVQRPPMALAS
QMPPPLTTGLMSHARLPHVARGPCGSLSGVRGNQAQAALKAEQDMKAKQRAEVLQSTQRFFSEQQQSKQIGGGKAQKVDSDSSKPPETLT

--------------------------------------------------------------
>102411_102411_2_ZNF569-PRRC2C_ZNF569_chr19_37935809_ENST00000392149_PRRC2C_chr1_171544066_ENST00000426496_length(transcript)=1908nt_BP=201nt
GCCCCTGGTGTAACGGACCGAGACTTGTGGCGCTCTCAGCCACCGACAGCGCCGGCCTCAGTGCCGCCTCTGTCCCAGCCCGCGCCGGCT
CTGCCACTTTGGCAGCGTTAAGTGTGGAATCGGGGCCTGTGTCCGCGGGCTTGCTCTACTTCTGCAGGCCCCATCCCTTCCCAGAAAGAA
GAGGAAATGACTGAGTCCCAGATGGAGTCTGCACGCAAAGCATGGGAGAATTCTCCAAATGTAAGGGAAAAGGGGTCTCCAGTAACTTCC
ACAGCACCTCCAATTGCAACTGGAGTCAGCAGTAGTGCCAGTGGACCAAGCACTGCTAATTACAATTCGTTCTCAAGTGCATCCATGCCC
CAGATTCCTGTTGCTTCAGTCACTCCTACAGCATCACTATCAGGAGCTGGTACATACACTACCTCTTCTTTGAGCACAAAATCTACAACC
ACATCGGACCCTCCAAATATTTGTAAAGTGAAACCTCAGCAGTTACAGACAAGCAGCCTGCCTTCTGCAAGTCATTTTTCACAGTTAAGC
TGTATGCCTTCCCTTATTGCCCAGCAGCAACAGAATCCGCAAGTTTATGTGTCTCAGTCTGCAGCAGCTCAAATCCCAGCCTTCTATATG
GACACAAGTCATTTATTCAATACCCAACATGCACGATTGGCTCCGCCATCCTTGGCTCAACAACAGGGTTTCCAACCAGGTCTCTCTCAG
CCAACTTCAGTTCAGCAGATTCCAATCCCTATTTATGCACCACTGCAAGGGCAGCATCAAGCCCAACTGAGTTTGGGGGCTGGCCCTGCT
GTTTCCCAGGCTCAGGAATTGTTCAGCTCCTCACTTCAACCATATAGATCTCAGCCAGCTTTTATGCAAAGCAGTTTATCCCAGCCATCT
GTGGTCCTTTCTGGTACTGCTATTCACAACTTTCCAACTGTCCAACACCAAGAACTTGCCAAGGCACAATCCGGTCTTGCCTTTCAGCAA
ACATCAAATACTCAGCCCATTCCTATATTGTATGAACATCAACTGGGGCAGGCATCAGGACTAGGAGGTTCCCAGCTGATTGACACACAT
CTTCTCCAGGCCAGAGCAAATCTTACCCAGGCCTCAAATCTTTATTCTGGACAAGTACAACAGCCTGGTCAGACAAATTTTTATAACACT
GCCCAGTCACCAAGTGCTCTCCAGCAGGTTACAGTACCTTTACCAGCATCGCAGCTTTCCTTGCCTAATTTTGGATCTACAGGGCAACCT
CTAATTGCTTTGCCTCAGACTCTTCAGCCCCCATTACAGCATACCACTCCCCAAGCACAGGCTCAGAGTCTGAGTCGTCCTGCACAAGTA
AGCCAGCCTTTCAGAGGATTAATTCCTGCTGGAACACAGCATAGCATGATTGCAACCACAGGAAAAATGTCTGAAATGGAACTAAAAGCC
TTTGGAAGTGGCATTGATATAAAACCAGGCACACCTCCAATCGCTGGTAGAAGCACCACACCAACATCTAGTCCCTTCCGGGCTACTTCT
ACAAGTCCGAACAGCCAGTCCAGCAAAATGAACAGCATTGTCTACCAGAAGCAGTTCCAGTCAGCCCCTGCCACTGTGAGAATGACACAA
CCATTTCCTACACAGTTTGCACCCCAGGCAAAGCAGAGAGCAGAGGTTCTTCAGTCCACGCAACGGTTCTTCTCTGAACAGCAACAGAGC
AAACAGATAGGAGGAGGCAAAGCCCAGAAAGTGGACAGTGATTCAAGTAAACCTCCTGAAACACTGACCGACCCTCCTGGGGTCTGTCAG
GAAAAAGTAGAAGAAAAGCCACCCCCTGCACCCTCCATAGCCACCAAACCTGTTAGAACTGGACCAATCAAACCTCAGGCGATCAAAACC

>102411_102411_2_ZNF569-PRRC2C_ZNF569_chr19_37935809_ENST00000392149_PRRC2C_chr1_171544066_ENST00000426496_length(amino acids)=593AA_BP=24
MCPRACSTSAGPIPSQKEEEMTESQMESARKAWENSPNVREKGSPVTSTAPPIATGVSSSASGPSTANYNSFSSASMPQIPVASVTPTAS
LSGAGTYTTSSLSTKSTTTSDPPNICKVKPQQLQTSSLPSASHFSQLSCMPSLIAQQQQNPQVYVSQSAAAQIPAFYMDTSHLFNTQHAR
LAPPSLAQQQGFQPGLSQPTSVQQIPIPIYAPLQGQHQAQLSLGAGPAVSQAQELFSSSLQPYRSQPAFMQSSLSQPSVVLSGTAIHNFP
TVQHQELAKAQSGLAFQQTSNTQPIPILYEHQLGQASGLGGSQLIDTHLLQARANLTQASNLYSGQVQQPGQTNFYNTAQSPSALQQVTV
PLPASQLSLPNFGSTGQPLIALPQTLQPPLQHTTPQAQAQSLSRPAQVSQPFRGLIPAGTQHSMIATTGKMSEMELKAFGSGIDIKPGTP
PIAGRSTTPTSSPFRATSTSPNSQSSKMNSIVYQKQFQSAPATVRMTQPFPTQFAPQAKQRAEVLQSTQRFFSEQQQSKQIGGGKAQKVD

--------------------------------------------------------------
>102411_102411_3_ZNF569-PRRC2C_ZNF569_chr19_37935809_ENST00000589833_PRRC2C_chr1_171544066_ENST00000392078_length(transcript)=2244nt_BP=300nt
AGGGATGTAAACAGCTGGAAAGAACTTTGCTTCAATCATTACAACAAGGAAACTACAAACTTCTACCGTACAACAAGGAAATGGACAAAC
TACAAAATAATTTTTCTAGGACCCTTCAGAGAACTGAGGTCACAGGGCAACCAAGTAATCTTAAATCTGGGGAAAGAAAGATGCCAGCTG
AGAGAAACAGGACTCAAGCTTTACTTACCTGGGATGGACTCTGCCAGACACCATATAAGCCACTCTACTTCTGCAGGCCCCATCCCTTCC
CAGAAAGAAGAGGAAATGACTGAGTCCCAGATGGAGTCTGCACGCAAAGCATGGGAGAATTCTCCAAATGTAAGGGAAAAGGGGTCTCCA
GTAACTTCCACAGCACCTCCAATTGCAACTGGAGTCAGCAGTAGTGCCAGTGGACCAAGCACTGCTAATTACAATTCGTTCTCAAGTGCA
TCCATGCCCCAGATTCCTGTTGCTTCAGTCACTCCTACAGCATCACTATCAGGAGCTGGTACATACACTACCTCTTCTTTGAGCACAAAA
TCTACAACCACATCGGACCCTCCAAATATTTGTAAAGTGAAACCTCAGCAGTTACAGACAAGCAGCCTGCCTTCTGCAAGTCATTTTTCA
CAGTTAAGCTGTATGCCTTCCCTTATTGCCCAGCAGCAACAGAATCCGCAAGTTTATGTGTCTCAGTCTGCAGCAGCTCAAATCCCAGCC
TTCTATATGGACACAAGTCATTTATTCAATACCCAACATGCACGATTGGCTCCGCCATCCTTGGCTCAACAACAGGGTTTCCAACCAGGT
CTCTCTCAGCCAACTTCAGTTCAGCAGATTCCAATCCCTATTTATGCACCACTGCAAGGGCAGCATCAAGCCCAACTGAGTTTGGGGGCT
GGCCCTGCTGTTTCCCAGGCTCAGGAATTGTTCAGCTCCTCACTTCAACCATATAGATCTCAGCCAGCTTTTATGCAAAGCAGTTTATCC
CAGCCATCTGTGGTCCTTTCTGGTACTGCTATTCACAACTTTCCAACTGTCCAACACCAAGAACTTGCCAAGGCACAATCCGGTCTTGCC
TTTCAGCAAACATCAAATACTCAGCCCATTCCTATATTGTATGAACATCAACTGGGGCAGGCATCAGGACTAGGAGGTTCCCAGCTGATT
GACACACATCTTCTCCAGGCCAGAGCAAATCTTACCCAGGCCTCAAATCTTTATTCTGGACAAGTACAACAGCCTGGTCAGACAAATTTT
TATAACACTGCCCAGTCACCAAGTGCTCTCCAGCAGGTTACAGTACCTTTACCAGCATCGCAGCTTTCCTTGCCTAATTTTGGATCTACA
GGGCAACCTCTAATTGCTTTGCCTCAGACTCTTCAGCCCCCATTACAGCATACCACTCCCCAAGCACAGGCTCAGAGTCTGAGTCGTCCT
GCACAAGTAAGCCAGCCTTTCAGAGGATTAATTCCTGCTGGAACACAGCATAGCATGATTGCAACCACAGGAAAAATGTCTGAAATGGAA
CTAAAAGCCTTTGGAAGTGGCATTGATATAAAACCAGGCACACCTCCAATCGCTGGTAGAAGCACCACACCAACATCTAGTCCCTTCCGG
GCTACTTCTACAAGTCCGAACAGCCAGTCCAGCAAAATGAACAGCATTGTCTACCAGAAGCAGTTCCAGTCAGCCCCTGCCACTGTGAGA
ATGACACAACCATTTCCTACACAGTTTGCACCCCAGATTCTCTCCCAGCCTAACCTGGTCCCTCCATTGGTAAGAGCCCCACATACTAAC
ACCTTCCCAGCGCCTGTTCAGAGGCCACCAATGGCACTGGCCAGTCAGATGCCTCCTCCGCTGACCACAGGCCTCATGAGCCATGCTCGT
TTGCCACATGTAGCCAGGGGTCCTTGTGGATCACTATCTGGAGTCAGAGGTAATCAGGCCCAGGCTGCGTTGAAGGCTGAACAAGACATG
AAGGCAAAGCAGAGAGCAGAGGTTCTTCAGTCCACGCAACGGTTCTTCTCTGAACAGCAACAGAGCAAACAGATAGGAGGAGGCAAAGCC
CAGAAAGTGGACAGTGATTCAAGTAAACCTCCTGAAACACTGACCGACCCTCCTGGGGTCTGTCAGGAAAAAGTAGAAGAAAAGCCACCC

>102411_102411_3_ZNF569-PRRC2C_ZNF569_chr19_37935809_ENST00000589833_PRRC2C_chr1_171544066_ENST00000392078_length(amino acids)=706AA_BP=58
MRSQGNQVILNLGKERCQLRETGLKLYLPGMDSARHHISHSTSAGPIPSQKEEEMTESQMESARKAWENSPNVREKGSPVTSTAPPIATG
VSSSASGPSTANYNSFSSASMPQIPVASVTPTASLSGAGTYTTSSLSTKSTTTSDPPNICKVKPQQLQTSSLPSASHFSQLSCMPSLIAQ
QQQNPQVYVSQSAAAQIPAFYMDTSHLFNTQHARLAPPSLAQQQGFQPGLSQPTSVQQIPIPIYAPLQGQHQAQLSLGAGPAVSQAQELF
SSSLQPYRSQPAFMQSSLSQPSVVLSGTAIHNFPTVQHQELAKAQSGLAFQQTSNTQPIPILYEHQLGQASGLGGSQLIDTHLLQARANL
TQASNLYSGQVQQPGQTNFYNTAQSPSALQQVTVPLPASQLSLPNFGSTGQPLIALPQTLQPPLQHTTPQAQAQSLSRPAQVSQPFRGLI
PAGTQHSMIATTGKMSEMELKAFGSGIDIKPGTPPIAGRSTTPTSSPFRATSTSPNSQSSKMNSIVYQKQFQSAPATVRMTQPFPTQFAP
QILSQPNLVPPLVRAPHTNTFPAPVQRPPMALASQMPPPLTTGLMSHARLPHVARGPCGSLSGVRGNQAQAALKAEQDMKAKQRAEVLQS

--------------------------------------------------------------
>102411_102411_4_ZNF569-PRRC2C_ZNF569_chr19_37935809_ENST00000589833_PRRC2C_chr1_171544066_ENST00000426496_length(transcript)=2007nt_BP=300nt
AGGGATGTAAACAGCTGGAAAGAACTTTGCTTCAATCATTACAACAAGGAAACTACAAACTTCTACCGTACAACAAGGAAATGGACAAAC
TACAAAATAATTTTTCTAGGACCCTTCAGAGAACTGAGGTCACAGGGCAACCAAGTAATCTTAAATCTGGGGAAAGAAAGATGCCAGCTG
AGAGAAACAGGACTCAAGCTTTACTTACCTGGGATGGACTCTGCCAGACACCATATAAGCCACTCTACTTCTGCAGGCCCCATCCCTTCC
CAGAAAGAAGAGGAAATGACTGAGTCCCAGATGGAGTCTGCACGCAAAGCATGGGAGAATTCTCCAAATGTAAGGGAAAAGGGGTCTCCA
GTAACTTCCACAGCACCTCCAATTGCAACTGGAGTCAGCAGTAGTGCCAGTGGACCAAGCACTGCTAATTACAATTCGTTCTCAAGTGCA
TCCATGCCCCAGATTCCTGTTGCTTCAGTCACTCCTACAGCATCACTATCAGGAGCTGGTACATACACTACCTCTTCTTTGAGCACAAAA
TCTACAACCACATCGGACCCTCCAAATATTTGTAAAGTGAAACCTCAGCAGTTACAGACAAGCAGCCTGCCTTCTGCAAGTCATTTTTCA
CAGTTAAGCTGTATGCCTTCCCTTATTGCCCAGCAGCAACAGAATCCGCAAGTTTATGTGTCTCAGTCTGCAGCAGCTCAAATCCCAGCC
TTCTATATGGACACAAGTCATTTATTCAATACCCAACATGCACGATTGGCTCCGCCATCCTTGGCTCAACAACAGGGTTTCCAACCAGGT
CTCTCTCAGCCAACTTCAGTTCAGCAGATTCCAATCCCTATTTATGCACCACTGCAAGGGCAGCATCAAGCCCAACTGAGTTTGGGGGCT
GGCCCTGCTGTTTCCCAGGCTCAGGAATTGTTCAGCTCCTCACTTCAACCATATAGATCTCAGCCAGCTTTTATGCAAAGCAGTTTATCC
CAGCCATCTGTGGTCCTTTCTGGTACTGCTATTCACAACTTTCCAACTGTCCAACACCAAGAACTTGCCAAGGCACAATCCGGTCTTGCC
TTTCAGCAAACATCAAATACTCAGCCCATTCCTATATTGTATGAACATCAACTGGGGCAGGCATCAGGACTAGGAGGTTCCCAGCTGATT
GACACACATCTTCTCCAGGCCAGAGCAAATCTTACCCAGGCCTCAAATCTTTATTCTGGACAAGTACAACAGCCTGGTCAGACAAATTTT
TATAACACTGCCCAGTCACCAAGTGCTCTCCAGCAGGTTACAGTACCTTTACCAGCATCGCAGCTTTCCTTGCCTAATTTTGGATCTACA
GGGCAACCTCTAATTGCTTTGCCTCAGACTCTTCAGCCCCCATTACAGCATACCACTCCCCAAGCACAGGCTCAGAGTCTGAGTCGTCCT
GCACAAGTAAGCCAGCCTTTCAGAGGATTAATTCCTGCTGGAACACAGCATAGCATGATTGCAACCACAGGAAAAATGTCTGAAATGGAA
CTAAAAGCCTTTGGAAGTGGCATTGATATAAAACCAGGCACACCTCCAATCGCTGGTAGAAGCACCACACCAACATCTAGTCCCTTCCGG
GCTACTTCTACAAGTCCGAACAGCCAGTCCAGCAAAATGAACAGCATTGTCTACCAGAAGCAGTTCCAGTCAGCCCCTGCCACTGTGAGA
ATGACACAACCATTTCCTACACAGTTTGCACCCCAGGCAAAGCAGAGAGCAGAGGTTCTTCAGTCCACGCAACGGTTCTTCTCTGAACAG
CAACAGAGCAAACAGATAGGAGGAGGCAAAGCCCAGAAAGTGGACAGTGATTCAAGTAAACCTCCTGAAACACTGACCGACCCTCCTGGG
GTCTGTCAGGAAAAAGTAGAAGAAAAGCCACCCCCTGCACCCTCCATAGCCACCAAACCTGTTAGAACTGGACCAATCAAACCTCAGGCG

>102411_102411_4_ZNF569-PRRC2C_ZNF569_chr19_37935809_ENST00000589833_PRRC2C_chr1_171544066_ENST00000426496_length(amino acids)=627AA_BP=58
MRSQGNQVILNLGKERCQLRETGLKLYLPGMDSARHHISHSTSAGPIPSQKEEEMTESQMESARKAWENSPNVREKGSPVTSTAPPIATG
VSSSASGPSTANYNSFSSASMPQIPVASVTPTASLSGAGTYTTSSLSTKSTTTSDPPNICKVKPQQLQTSSLPSASHFSQLSCMPSLIAQ
QQQNPQVYVSQSAAAQIPAFYMDTSHLFNTQHARLAPPSLAQQQGFQPGLSQPTSVQQIPIPIYAPLQGQHQAQLSLGAGPAVSQAQELF
SSSLQPYRSQPAFMQSSLSQPSVVLSGTAIHNFPTVQHQELAKAQSGLAFQQTSNTQPIPILYEHQLGQASGLGGSQLIDTHLLQARANL
TQASNLYSGQVQQPGQTNFYNTAQSPSALQQVTVPLPASQLSLPNFGSTGQPLIALPQTLQPPLQHTTPQAQAQSLSRPAQVSQPFRGLI
PAGTQHSMIATTGKMSEMELKAFGSGIDIKPGTPPIAGRSTTPTSSPFRATSTSPNSQSSKMNSIVYQKQFQSAPATVRMTQPFPTQFAP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZNF569-PRRC2C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF569-PRRC2C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF569-PRRC2C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource