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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BRE-PRKCE (FusionGDB2 ID:10242)

Fusion Gene Summary for BRE-PRKCE

check button Fusion gene summary
Fusion gene informationFusion gene name: BRE-PRKCE
Fusion gene ID: 10242
HgeneTgene
Gene symbol

BRE

PRKCE

Gene ID

9577

5581

Gene nameBRISC and BRCA1 A complex member 2protein kinase C epsilon
SynonymsBRCC4|BRCC45|BREPKCE|nPKC-epsilon
Cytomap

2p23.2

2p21

Type of geneprotein-codingprotein-coding
DescriptionBRISC and BRCA1-A complex member 2BRCA1-A complex subunit BREBRCA1/BRCA2-containing complex subunit 45BRCA1/BRCA2-containing complex, subunit 4brain and reproductive organ-expressed (TNFRSF1A modulator)brain and reproductive organ-expressed proteinprotein kinase C epsilon type
Modification date2020031320200327
UniProtAcc.

Q02156

Ensembl transtripts involved in fusion geneENST00000342045, ENST00000344773, 
ENST00000361704, ENST00000379624, 
ENST00000379632, ENST00000603461, 
ENST00000394874, ENST00000467135, 
ENST00000306156, 
Fusion gene scores* DoF score13 X 9 X 8=93611 X 12 X 7=924
# samples 1512
** MAII scorelog2(15/936*10)=-2.64154602908752
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/924*10)=-2.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BRE [Title/Abstract] AND PRKCE [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBRE(28268666)-PRKCE(46313347), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBRE

GO:0043066

negative regulation of apoptotic process

15465831

TgenePRKCE

GO:0006468

protein phosphorylation

18556656

TgenePRKCE

GO:0018105

peptidyl-serine phosphorylation

15695813


check buttonFusion gene breakpoints across BRE (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PRKCE (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-C8-A134-01ABREchr2

28268666

-PRKCEchr2

46313347

+
ChimerDB4BRCATCGA-C8-A134-01ABREchr2

28268666

+PRKCEchr2

46313347

+


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Fusion Gene ORF analysis for BRE-PRKCE

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000342045ENST00000394874BREchr2

28268666

+PRKCEchr2

46313347

+
5CDS-intronENST00000342045ENST00000467135BREchr2

28268666

+PRKCEchr2

46313347

+
5CDS-intronENST00000344773ENST00000394874BREchr2

28268666

+PRKCEchr2

46313347

+
5CDS-intronENST00000344773ENST00000467135BREchr2

28268666

+PRKCEchr2

46313347

+
5CDS-intronENST00000361704ENST00000394874BREchr2

28268666

+PRKCEchr2

46313347

+
5CDS-intronENST00000361704ENST00000467135BREchr2

28268666

+PRKCEchr2

46313347

+
5CDS-intronENST00000379624ENST00000394874BREchr2

28268666

+PRKCEchr2

46313347

+
5CDS-intronENST00000379624ENST00000467135BREchr2

28268666

+PRKCEchr2

46313347

+
5CDS-intronENST00000379632ENST00000394874BREchr2

28268666

+PRKCEchr2

46313347

+
5CDS-intronENST00000379632ENST00000467135BREchr2

28268666

+PRKCEchr2

46313347

+
In-frameENST00000342045ENST00000306156BREchr2

28268666

+PRKCEchr2

46313347

+
In-frameENST00000344773ENST00000306156BREchr2

28268666

+PRKCEchr2

46313347

+
In-frameENST00000361704ENST00000306156BREchr2

28268666

+PRKCEchr2

46313347

+
In-frameENST00000379624ENST00000306156BREchr2

28268666

+PRKCEchr2

46313347

+
In-frameENST00000379632ENST00000306156BREchr2

28268666

+PRKCEchr2

46313347

+
intron-3CDSENST00000603461ENST00000306156BREchr2

28268666

+PRKCEchr2

46313347

+
intron-intronENST00000603461ENST00000394874BREchr2

28268666

+PRKCEchr2

46313347

+
intron-intronENST00000603461ENST00000467135BREchr2

28268666

+PRKCEchr2

46313347

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000344773BREchr228268666+ENST00000306156PRKCEchr246313347+45947081381484448
ENST00000379624BREchr228268666+ENST00000306156PRKCEchr246313347+45736871171463448
ENST00000342045BREchr228268666+ENST00000306156PRKCEchr246313347+45977111411487448
ENST00000379632BREchr228268666+ENST00000306156PRKCEchr246313347+45967101401486448
ENST00000361704BREchr228268666+ENST00000306156PRKCEchr246313347+4530644741420448

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000344773ENST00000306156BREchr228268666+PRKCEchr246313347+0.0002230380.999777
ENST00000379624ENST00000306156BREchr228268666+PRKCEchr246313347+0.0002163160.9997837
ENST00000342045ENST00000306156BREchr228268666+PRKCEchr246313347+0.0002072630.99979275
ENST00000379632ENST00000306156BREchr228268666+PRKCEchr246313347+0.0002072360.99979275
ENST00000361704ENST00000306156BREchr228268666+PRKCEchr246313347+0.0002180690.9997819

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Fusion Genomic Features for BRE-PRKCE


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
BREchr228268666+PRKCEchr246313346+9.84E-050.99990153
BREchr228268666+PRKCEchr246313346+9.84E-050.99990153

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for BRE-PRKCE


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:28268666/chr2:46313347)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.PRKCE

Q02156

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1. Phosphorylates NLRP5/MATER and may thereby modulate AKT pathway activation in cumulus cells (PubMed:19542546). {ECO:0000269|PubMed:11884385, ECO:0000269|PubMed:1374067, ECO:0000269|PubMed:15355962, ECO:0000269|PubMed:16757566, ECO:0000269|PubMed:17603037, ECO:0000269|PubMed:17875639, ECO:0000269|PubMed:17875724, ECO:0000269|PubMed:19542546}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBREchr2:28268666chr2:46313347ENST00000342045+71330_147190384.0RegionNote=UEV-like 1
HgeneBREchr2:28268666chr2:46313347ENST00000344773+61330_147190528.6666666666666RegionNote=UEV-like 1
HgeneBREchr2:28268666chr2:46313347ENST00000361704+61330_147190511.0RegionNote=UEV-like 1
HgeneBREchr2:28268666chr2:46313347ENST00000379624+61230_147190384.0RegionNote=UEV-like 1
HgeneBREchr2:28268666chr2:46313347ENST00000379632+71430_147190511.0RegionNote=UEV-like 1
TgenePRKCEchr2:28268666chr2:46313347ENST00000306156915669_737479738.0DomainAGC-kinase C-terminal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBREchr2:28268666chr2:46313347ENST00000342045+713275_364190384.0RegionNote=UEV-like 2
HgeneBREchr2:28268666chr2:46313347ENST00000344773+613275_364190528.6666666666666RegionNote=UEV-like 2
HgeneBREchr2:28268666chr2:46313347ENST00000361704+613275_364190511.0RegionNote=UEV-like 2
HgeneBREchr2:28268666chr2:46313347ENST00000379624+612275_364190384.0RegionNote=UEV-like 2
HgeneBREchr2:28268666chr2:46313347ENST00000379632+714275_364190511.0RegionNote=UEV-like 2
TgenePRKCEchr2:28268666chr2:46313347ENST000003061569151_117479738.0DomainC2
TgenePRKCEchr2:28268666chr2:46313347ENST00000306156915408_668479738.0DomainProtein kinase
TgenePRKCEchr2:28268666chr2:46313347ENST00000306156915414_422479738.0Nucleotide bindingATP
TgenePRKCEchr2:28268666chr2:46313347ENST00000306156915169_220479738.0Zinc fingerPhorbol-ester/DAG-type 1
TgenePRKCEchr2:28268666chr2:46313347ENST00000306156915242_292479738.0Zinc fingerPhorbol-ester/DAG-type 2


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Fusion Gene Sequence for BRE-PRKCE


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>10242_10242_1_BRE-PRKCE_BRE_chr2_28268666_ENST00000342045_PRKCE_chr2_46313347_ENST00000306156_length(transcript)=4597nt_BP=711nt
GGGTACCTGTACCCCACGTAGTCGCCGGTTACCGATCGGACTAAGTTCCAGAAGCAAGAGATAAAGTAATAATGGGTACTGTGGGGAAAA
ACACAGAAGAACAATTCGGTAATATAGTGGTGATTTACAAGTCAAGTTAAAATGTCCCCAGAAGTGGCCTTGAACCGAATATCTCCAATG
CTCTCCCCTTTCATATCTAGCGTGGTCCGGAATGGAAAAGTGGGACTGGATGCTACAAACTGTTTGAGGATAACTGACTTAAAATCTGGC
TGCACATCATTGACTCCTGGGCCCAACTGTGACCGATTTAAACTGCACATACCATATGCTGGAGAGACATTAAAGTGGGATATCATTTTC
AATGCCCAATACCCAGAACTGCCTCCCGATTTTATCTTTGGAGAAGATGCTGAATTCCTGCCAGACCCCTCAGCTTTGCAGAATCTTGCC
TCCTGGAATCCTTCAAATCCTGAATGTCTCTTACTTGTGGTGAAGGAACTTGTGCAACAATATCACCAATTCCAATGTAGCCGCCTCCGG
GAGAGCTCCCGCCTCATGTTTGAATACCAGACATTACTGGAGGAGCCACAGTATGGAGAGAACATGGAAATTTATGCTGGGAAAAAAAAC
AACTGGACTGGTGAATTTTCAGCTCGTTTCCTTTTGAAGCTGCCCGTAGATTTCAGCAATATCCCCACATACCTTCTCAAGGACCGCCTC
TTTTTCGTCATGGAATATGTAAATGGTGGAGACCTCATGTTTCAGATTCAGCGCTCCCGAAAATTCGACGAGCCTCGTTCACGGTTCTAT
GCTGCAGAGGTCACATCGGCCCTCATGTTCCTCCACCAGCATGGAGTCATCTACAGGGATTTGAAACTGGACAACATCCTTCTGGATGCA
GAAGGTCACTGCAAGCTGGCTGACTTCGGGATGTGCAAGGAAGGGATTCTGAATGGTGTGACGACCACCACGTTCTGTGGGACTCCTGAC
TACATAGCTCCTGAGATCCTGCAGGAGTTGGAGTATGGCCCCTCCGTGGACTGGTGGGCCCTGGGGGTGCTGATGTACGAGATGATGGCT
GGACAGCCTCCCTTTGAGGCCGACAATGAGGACGACCTATTTGAGTCCATCCTCCATGACGACGTGCTGTACCCAGTCTGGCTCAGCAAG
GAGGCTGTCAGCATCTTGAAAGCTTTCATGACGAAGAATCCCCACAAGCGCCTGGGCTGTGTGGCATCGCAGAATGGCGAGGACGCCATC
AAGCAGCACCCATTCTTCAAAGAGATTGACTGGGTGCTCCTGGAGCAGAAGAAGATCAAGCCACCCTTCAAACCACGCATTAAAACCAAA
AGAGACGTCAATAATTTTGACCAAGACTTTACCCGGGAAGAGCCGGTACTCACCCTTGTGGACGAAGCAATTGTAAAGCAGATCAACCAG
GAGGAATTCAAAGGTTTCTCCTACTTTGGTGAAGACCTGATGCCCTGAGAGCCCACTGCAGTTGGACTTTGCCGATGCTGCAAGAAGGGG
TGCAGAGAAGACTCCTGTGTTGGAGACACTCAGCAGGTCTTGAACTACTTCTCCTCCTCGGAGCCCCAGTCCCATGTCCACTGTCTATTT
ATTGCATTCCCTTGCCCCAGGCCACCTCCTCCCCCTCCCACCTGGTGACCAGAAGGCGCTCTCGGTTCTTGTCTCACCAGTAATGCAGAC
TCATTGGGTCAGCAATTAGCTGTATACACTGCCGTGTTTGGACCATTGGCAAGCCTGGTTCCACTCCTCAGGGGCTCCTGGCAGTGAAGC
AACTTCAGTTCTTTTACTGCAAAGAACAGAAAAAAGAAAGAAAGCAAACAAGAAGACTCCGGCTCTGCTATCGGACACAGATCCTGATCC
CTCTTGCTTCTTTTCCCTCCTGCACCGCAGCTTGCCATCCCTGCCCTTCTGTCCTGGAGAAGAGACTGGTGCTTCTCCGCACACACGAGG
GAGGGCGCCCTTGAGGCATGCCCTCTGAGGGAGGGAGACCAGAGATGCAGGGATTGGCCAGCTGGGTTGGTTTGCTCTGGAATGGCTAAC
TCTTGCCTGCTTTGGTTTTAGCTTTTCAGCATGCCAAAGTCATGTAAGTTTGTGTCTTGTGGAAGAAATCCTCTTTGTGGAAAAAGAAAC
AGGGTTTTGAACTCTGTTAACATTTGAAAAATATATTTTCAAATTCACTTTCTAATTGGCCAAAAGAGATGAGTTCCAGTCTGAATACAG
GTAGATATTAAAGGGCTAATAAAAAATGAGAAACCGGTCGTCCAAGGTGGATGCTGTCAATGCCCGAGTGACACATGAGAGCTGTATGAA
TTGAGAGAAAAGGCAACAAGTAGCATTCTTCATCATTCAAGTTCTACCTGGACACAAAGGCGAGGACCCTGGGGTTCCAACAAAGCTCAG
CTCCCAGATTCTCTTTCCAGTTTCATCCTAAGTTCCTAGCATAAACACTATTTATTTTCTGCAGCAGTGTGTTATTTTTGCGCACTTATA
CAAAATGGTAGTACTACTGTGTTGTGGTTTTTAAACATTAAACATGTAAAGTTATATACGAAATATCTGCTTTTGGAATAAGCAGAATGA
GGCTAAACATGGGTTATACAAAGGGTATCTGGAAACTGAAGAGCAACTTGTTAGAAAACTGACAATGTCGCAAGATGTACTCAGTTTTGT
TTCTGTGTGACATGCAATGGCAACTCATGTGGACACTATTGAAGGGATGTGACATTACCTCCTGTAGATATGCTAACAGTGTTATTCTTT
CATTTCCAAGGGTTCTCTGTGGCTTTGTGTATATGTTTCCCAGAGGTCATTTGATTACCTAATTTACTGAACTGATTTAGCAGGGAATGG
AATCCATTCCAACTATTGCACGTGGATTTCCCAGCTGCCCCTAAATATATATACTTGTGAGTGGCAAAGTGGCACTAATGAAGCTTTTGC
CTTTTGTACATTTGAGATTTTTGTATATAGTGTTTGCTGCAAGGCCTGTGGAATTAATTCGTTGCATATAGAGGTATCAACTGCTGCATG
TTCAGGCATATTATAAAACTTTAGTCTATGAAAGAATAATTATAATAATGTCCAGGTGCAATACTCTGTAAGTCTATTGGTTCAAGTTAC
CGAGAGATAGGTGTGTTCCTTTATGGGGGATGGGGGGGTGTGTTGGGGATTCTTTGTATTGTTTATTTCATTTTGGTTTATTTTAAAAGA
TGTAAACATATATTAAGCTATATTAAATCTCACATACAGTTCTTCTGTGCTCTATTATACCCTGATAGAGATGGGGGAGAGAAAGGAATG
TTTTTGATGGTGGTTTCAAAGCTCGGACAGTAACTATCTTGAGCCCATTAGAGAGTCTGTGTCCATATTTGCATCTGGCTGGTCATAGCC
TTTGTTACTAATGATGACATTCAGTTCTCTTTTGTTTTTATTTTTTAAAAACTCAGGTGTAATTATTATCTGTTCTTAAGATAATTGCAA
ATATTAAATATTATGATATATCAATTCATGTGTTTGGCATACCAGTGAATGATGAAGAACATGAGATTAATTTAATTTATCTTCGGTAAC
TTGACATTCTGGAGAGAGACTATCTTCTGGAGTTGAGTACAAGCACAGAAACATCTTTACGGTGGCATCATCTCATTTTTTAGGAAGACA
TGATAATACTGCCCATCATATTCATGTGTAACTACTGTTCTTTCTTCTGCTTTCTTCACCATAATAAACTTTGGACAACCAAGCAAGCTC
TAACCGCAATGCCAGATGGCCTTGTCCGAGGGCCTAGTGTTTGCACGGCAGTGGGAACTGGGCCTTTCCTACAGGACAACTGGCAAGTTT
GCTGGGAAGTCAAATAATACATTCCACCTGGCAGCTGAAGGCAGCCAGTCAGTCTGTCCCAGAAAGGGCCCTTTTCAGCACCCAAAGCTG
GGCTGGCTGGGATGCCTCTGGCTGGTGAAGTTCTCACATAGGCTGATTTAAATCCAGCAAAGGTCTATAGAAAAAGGCTTGCGTGTTCGT
TGAGTAATCATTGTTTCATTTTCATTTTTACGAGAGTTTGAAAATAGACACACTGTTAACACTTCTGCCAGTTTTTTCTGATCTTTCCAG
CCCCACCCCCTTTCTCTTTCTCTCTCTCTCTCAAAGAAAAAAAAAATGGGAGTGCAAAAAAAACAAAGCCAAAAAATATATGAAGGATAG
CTGTTCTTCTGTGTTCTCTCATTATGGACTTTGTGAAGTAGAAACATAATTTTTTTTCCTCCAAAGGTGAAAAAACAATGCATTCTTGCT
TTAAAAAAAAAAAAGAAGGCTAAAAAATTACCTCTTTTTAAATTATGTGCAAAATAATTCTGGCTAACTGTAAAATGTATTCAATTTTAG
GATTTTTTTTTTTTGTATTGTGATGCTTTATTTGTACATTTTTTTCCTTTCTGGATGTAATTTTAATCTCTTGCCATTCATTAGTGTTAT
TTCATTGTAAACGTTATTGTGCCAAATGTACTGTATTCAAAAGGATGTGAATGTGTATTGTTTCAGAACCTAATAAATACAATGACGTTA

>10242_10242_1_BRE-PRKCE_BRE_chr2_28268666_ENST00000342045_PRKCE_chr2_46313347_ENST00000306156_length(amino acids)=448AA_BP=190
MSPEVALNRISPMLSPFISSVVRNGKVGLDATNCLRITDLKSGCTSLTPGPNCDRFKLHIPYAGETLKWDIIFNAQYPELPPDFIFGEDA
EFLPDPSALQNLASWNPSNPECLLLVVKELVQQYHQFQCSRLRESSRLMFEYQTLLEEPQYGENMEIYAGKKNNWTGEFSARFLLKLPVD
FSNIPTYLLKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGIL
NGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKR

--------------------------------------------------------------
>10242_10242_2_BRE-PRKCE_BRE_chr2_28268666_ENST00000344773_PRKCE_chr2_46313347_ENST00000306156_length(transcript)=4594nt_BP=708nt
GAGTGCGCACGCATCCTGCCCGCGGCGCGCGCGCAGGTCGGTGCGTCTGTCGGGGGCGCGCTCGGGTACCTGTACCCCACGTAGTCGCCG
GTTACCGATCGGACTAAGTTCCAGTGGTGATTTACAAGTCAAGTTAAAATGTCCCCAGAAGTGGCCTTGAACCGAATATCTCCAATGCTC
TCCCCTTTCATATCTAGCGTGGTCCGGAATGGAAAAGTGGGACTGGATGCTACAAACTGTTTGAGGATAACTGACTTAAAATCTGGCTGC
ACATCATTGACTCCTGGGCCCAACTGTGACCGATTTAAACTGCACATACCATATGCTGGAGAGACATTAAAGTGGGATATCATTTTCAAT
GCCCAATACCCAGAACTGCCTCCCGATTTTATCTTTGGAGAAGATGCTGAATTCCTGCCAGACCCCTCAGCTTTGCAGAATCTTGCCTCC
TGGAATCCTTCAAATCCTGAATGTCTCTTACTTGTGGTGAAGGAACTTGTGCAACAATATCACCAATTCCAATGTAGCCGCCTCCGGGAG
AGCTCCCGCCTCATGTTTGAATACCAGACATTACTGGAGGAGCCACAGTATGGAGAGAACATGGAAATTTATGCTGGGAAAAAAAACAAC
TGGACTGGTGAATTTTCAGCTCGTTTCCTTTTGAAGCTGCCCGTAGATTTCAGCAATATCCCCACATACCTTCTCAAGGACCGCCTCTTT
TTCGTCATGGAATATGTAAATGGTGGAGACCTCATGTTTCAGATTCAGCGCTCCCGAAAATTCGACGAGCCTCGTTCACGGTTCTATGCT
GCAGAGGTCACATCGGCCCTCATGTTCCTCCACCAGCATGGAGTCATCTACAGGGATTTGAAACTGGACAACATCCTTCTGGATGCAGAA
GGTCACTGCAAGCTGGCTGACTTCGGGATGTGCAAGGAAGGGATTCTGAATGGTGTGACGACCACCACGTTCTGTGGGACTCCTGACTAC
ATAGCTCCTGAGATCCTGCAGGAGTTGGAGTATGGCCCCTCCGTGGACTGGTGGGCCCTGGGGGTGCTGATGTACGAGATGATGGCTGGA
CAGCCTCCCTTTGAGGCCGACAATGAGGACGACCTATTTGAGTCCATCCTCCATGACGACGTGCTGTACCCAGTCTGGCTCAGCAAGGAG
GCTGTCAGCATCTTGAAAGCTTTCATGACGAAGAATCCCCACAAGCGCCTGGGCTGTGTGGCATCGCAGAATGGCGAGGACGCCATCAAG
CAGCACCCATTCTTCAAAGAGATTGACTGGGTGCTCCTGGAGCAGAAGAAGATCAAGCCACCCTTCAAACCACGCATTAAAACCAAAAGA
GACGTCAATAATTTTGACCAAGACTTTACCCGGGAAGAGCCGGTACTCACCCTTGTGGACGAAGCAATTGTAAAGCAGATCAACCAGGAG
GAATTCAAAGGTTTCTCCTACTTTGGTGAAGACCTGATGCCCTGAGAGCCCACTGCAGTTGGACTTTGCCGATGCTGCAAGAAGGGGTGC
AGAGAAGACTCCTGTGTTGGAGACACTCAGCAGGTCTTGAACTACTTCTCCTCCTCGGAGCCCCAGTCCCATGTCCACTGTCTATTTATT
GCATTCCCTTGCCCCAGGCCACCTCCTCCCCCTCCCACCTGGTGACCAGAAGGCGCTCTCGGTTCTTGTCTCACCAGTAATGCAGACTCA
TTGGGTCAGCAATTAGCTGTATACACTGCCGTGTTTGGACCATTGGCAAGCCTGGTTCCACTCCTCAGGGGCTCCTGGCAGTGAAGCAAC
TTCAGTTCTTTTACTGCAAAGAACAGAAAAAAGAAAGAAAGCAAACAAGAAGACTCCGGCTCTGCTATCGGACACAGATCCTGATCCCTC
TTGCTTCTTTTCCCTCCTGCACCGCAGCTTGCCATCCCTGCCCTTCTGTCCTGGAGAAGAGACTGGTGCTTCTCCGCACACACGAGGGAG
GGCGCCCTTGAGGCATGCCCTCTGAGGGAGGGAGACCAGAGATGCAGGGATTGGCCAGCTGGGTTGGTTTGCTCTGGAATGGCTAACTCT
TGCCTGCTTTGGTTTTAGCTTTTCAGCATGCCAAAGTCATGTAAGTTTGTGTCTTGTGGAAGAAATCCTCTTTGTGGAAAAAGAAACAGG
GTTTTGAACTCTGTTAACATTTGAAAAATATATTTTCAAATTCACTTTCTAATTGGCCAAAAGAGATGAGTTCCAGTCTGAATACAGGTA
GATATTAAAGGGCTAATAAAAAATGAGAAACCGGTCGTCCAAGGTGGATGCTGTCAATGCCCGAGTGACACATGAGAGCTGTATGAATTG
AGAGAAAAGGCAACAAGTAGCATTCTTCATCATTCAAGTTCTACCTGGACACAAAGGCGAGGACCCTGGGGTTCCAACAAAGCTCAGCTC
CCAGATTCTCTTTCCAGTTTCATCCTAAGTTCCTAGCATAAACACTATTTATTTTCTGCAGCAGTGTGTTATTTTTGCGCACTTATACAA
AATGGTAGTACTACTGTGTTGTGGTTTTTAAACATTAAACATGTAAAGTTATATACGAAATATCTGCTTTTGGAATAAGCAGAATGAGGC
TAAACATGGGTTATACAAAGGGTATCTGGAAACTGAAGAGCAACTTGTTAGAAAACTGACAATGTCGCAAGATGTACTCAGTTTTGTTTC
TGTGTGACATGCAATGGCAACTCATGTGGACACTATTGAAGGGATGTGACATTACCTCCTGTAGATATGCTAACAGTGTTATTCTTTCAT
TTCCAAGGGTTCTCTGTGGCTTTGTGTATATGTTTCCCAGAGGTCATTTGATTACCTAATTTACTGAACTGATTTAGCAGGGAATGGAAT
CCATTCCAACTATTGCACGTGGATTTCCCAGCTGCCCCTAAATATATATACTTGTGAGTGGCAAAGTGGCACTAATGAAGCTTTTGCCTT
TTGTACATTTGAGATTTTTGTATATAGTGTTTGCTGCAAGGCCTGTGGAATTAATTCGTTGCATATAGAGGTATCAACTGCTGCATGTTC
AGGCATATTATAAAACTTTAGTCTATGAAAGAATAATTATAATAATGTCCAGGTGCAATACTCTGTAAGTCTATTGGTTCAAGTTACCGA
GAGATAGGTGTGTTCCTTTATGGGGGATGGGGGGGTGTGTTGGGGATTCTTTGTATTGTTTATTTCATTTTGGTTTATTTTAAAAGATGT
AAACATATATTAAGCTATATTAAATCTCACATACAGTTCTTCTGTGCTCTATTATACCCTGATAGAGATGGGGGAGAGAAAGGAATGTTT
TTGATGGTGGTTTCAAAGCTCGGACAGTAACTATCTTGAGCCCATTAGAGAGTCTGTGTCCATATTTGCATCTGGCTGGTCATAGCCTTT
GTTACTAATGATGACATTCAGTTCTCTTTTGTTTTTATTTTTTAAAAACTCAGGTGTAATTATTATCTGTTCTTAAGATAATTGCAAATA
TTAAATATTATGATATATCAATTCATGTGTTTGGCATACCAGTGAATGATGAAGAACATGAGATTAATTTAATTTATCTTCGGTAACTTG
ACATTCTGGAGAGAGACTATCTTCTGGAGTTGAGTACAAGCACAGAAACATCTTTACGGTGGCATCATCTCATTTTTTAGGAAGACATGA
TAATACTGCCCATCATATTCATGTGTAACTACTGTTCTTTCTTCTGCTTTCTTCACCATAATAAACTTTGGACAACCAAGCAAGCTCTAA
CCGCAATGCCAGATGGCCTTGTCCGAGGGCCTAGTGTTTGCACGGCAGTGGGAACTGGGCCTTTCCTACAGGACAACTGGCAAGTTTGCT
GGGAAGTCAAATAATACATTCCACCTGGCAGCTGAAGGCAGCCAGTCAGTCTGTCCCAGAAAGGGCCCTTTTCAGCACCCAAAGCTGGGC
TGGCTGGGATGCCTCTGGCTGGTGAAGTTCTCACATAGGCTGATTTAAATCCAGCAAAGGTCTATAGAAAAAGGCTTGCGTGTTCGTTGA
GTAATCATTGTTTCATTTTCATTTTTACGAGAGTTTGAAAATAGACACACTGTTAACACTTCTGCCAGTTTTTTCTGATCTTTCCAGCCC
CACCCCCTTTCTCTTTCTCTCTCTCTCTCAAAGAAAAAAAAAATGGGAGTGCAAAAAAAACAAAGCCAAAAAATATATGAAGGATAGCTG
TTCTTCTGTGTTCTCTCATTATGGACTTTGTGAAGTAGAAACATAATTTTTTTTCCTCCAAAGGTGAAAAAACAATGCATTCTTGCTTTA
AAAAAAAAAAAGAAGGCTAAAAAATTACCTCTTTTTAAATTATGTGCAAAATAATTCTGGCTAACTGTAAAATGTATTCAATTTTAGGAT
TTTTTTTTTTTGTATTGTGATGCTTTATTTGTACATTTTTTTCCTTTCTGGATGTAATTTTAATCTCTTGCCATTCATTAGTGTTATTTC
ATTGTAAACGTTATTGTGCCAAATGTACTGTATTCAAAAGGATGTGAATGTGTATTGTTTCAGAACCTAATAAATACAATGACGTTAAGT

>10242_10242_2_BRE-PRKCE_BRE_chr2_28268666_ENST00000344773_PRKCE_chr2_46313347_ENST00000306156_length(amino acids)=448AA_BP=190
MSPEVALNRISPMLSPFISSVVRNGKVGLDATNCLRITDLKSGCTSLTPGPNCDRFKLHIPYAGETLKWDIIFNAQYPELPPDFIFGEDA
EFLPDPSALQNLASWNPSNPECLLLVVKELVQQYHQFQCSRLRESSRLMFEYQTLLEEPQYGENMEIYAGKKNNWTGEFSARFLLKLPVD
FSNIPTYLLKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGIL
NGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKR

--------------------------------------------------------------
>10242_10242_3_BRE-PRKCE_BRE_chr2_28268666_ENST00000361704_PRKCE_chr2_46313347_ENST00000306156_length(transcript)=4530nt_BP=644nt
GGTACCTGTACCCCACGTAGTCGCCGGTTACCGATCGGACTAAGTTCCAGTGGTGATTTACAAGTCAAGTTAAAATGTCCCCAGAAGTGG
CCTTGAACCGAATATCTCCAATGCTCTCCCCTTTCATATCTAGCGTGGTCCGGAATGGAAAAGTGGGACTGGATGCTACAAACTGTTTGA
GGATAACTGACTTAAAATCTGGCTGCACATCATTGACTCCTGGGCCCAACTGTGACCGATTTAAACTGCACATACCATATGCTGGAGAGA
CATTAAAGTGGGATATCATTTTCAATGCCCAATACCCAGAACTGCCTCCCGATTTTATCTTTGGAGAAGATGCTGAATTCCTGCCAGACC
CCTCAGCTTTGCAGAATCTTGCCTCCTGGAATCCTTCAAATCCTGAATGTCTCTTACTTGTGGTGAAGGAACTTGTGCAACAATATCACC
AATTCCAATGTAGCCGCCTCCGGGAGAGCTCCCGCCTCATGTTTGAATACCAGACATTACTGGAGGAGCCACAGTATGGAGAGAACATGG
AAATTTATGCTGGGAAAAAAAACAACTGGACTGGTGAATTTTCAGCTCGTTTCCTTTTGAAGCTGCCCGTAGATTTCAGCAATATCCCCA
CATACCTTCTCAAGGACCGCCTCTTTTTCGTCATGGAATATGTAAATGGTGGAGACCTCATGTTTCAGATTCAGCGCTCCCGAAAATTCG
ACGAGCCTCGTTCACGGTTCTATGCTGCAGAGGTCACATCGGCCCTCATGTTCCTCCACCAGCATGGAGTCATCTACAGGGATTTGAAAC
TGGACAACATCCTTCTGGATGCAGAAGGTCACTGCAAGCTGGCTGACTTCGGGATGTGCAAGGAAGGGATTCTGAATGGTGTGACGACCA
CCACGTTCTGTGGGACTCCTGACTACATAGCTCCTGAGATCCTGCAGGAGTTGGAGTATGGCCCCTCCGTGGACTGGTGGGCCCTGGGGG
TGCTGATGTACGAGATGATGGCTGGACAGCCTCCCTTTGAGGCCGACAATGAGGACGACCTATTTGAGTCCATCCTCCATGACGACGTGC
TGTACCCAGTCTGGCTCAGCAAGGAGGCTGTCAGCATCTTGAAAGCTTTCATGACGAAGAATCCCCACAAGCGCCTGGGCTGTGTGGCAT
CGCAGAATGGCGAGGACGCCATCAAGCAGCACCCATTCTTCAAAGAGATTGACTGGGTGCTCCTGGAGCAGAAGAAGATCAAGCCACCCT
TCAAACCACGCATTAAAACCAAAAGAGACGTCAATAATTTTGACCAAGACTTTACCCGGGAAGAGCCGGTACTCACCCTTGTGGACGAAG
CAATTGTAAAGCAGATCAACCAGGAGGAATTCAAAGGTTTCTCCTACTTTGGTGAAGACCTGATGCCCTGAGAGCCCACTGCAGTTGGAC
TTTGCCGATGCTGCAAGAAGGGGTGCAGAGAAGACTCCTGTGTTGGAGACACTCAGCAGGTCTTGAACTACTTCTCCTCCTCGGAGCCCC
AGTCCCATGTCCACTGTCTATTTATTGCATTCCCTTGCCCCAGGCCACCTCCTCCCCCTCCCACCTGGTGACCAGAAGGCGCTCTCGGTT
CTTGTCTCACCAGTAATGCAGACTCATTGGGTCAGCAATTAGCTGTATACACTGCCGTGTTTGGACCATTGGCAAGCCTGGTTCCACTCC
TCAGGGGCTCCTGGCAGTGAAGCAACTTCAGTTCTTTTACTGCAAAGAACAGAAAAAAGAAAGAAAGCAAACAAGAAGACTCCGGCTCTG
CTATCGGACACAGATCCTGATCCCTCTTGCTTCTTTTCCCTCCTGCACCGCAGCTTGCCATCCCTGCCCTTCTGTCCTGGAGAAGAGACT
GGTGCTTCTCCGCACACACGAGGGAGGGCGCCCTTGAGGCATGCCCTCTGAGGGAGGGAGACCAGAGATGCAGGGATTGGCCAGCTGGGT
TGGTTTGCTCTGGAATGGCTAACTCTTGCCTGCTTTGGTTTTAGCTTTTCAGCATGCCAAAGTCATGTAAGTTTGTGTCTTGTGGAAGAA
ATCCTCTTTGTGGAAAAAGAAACAGGGTTTTGAACTCTGTTAACATTTGAAAAATATATTTTCAAATTCACTTTCTAATTGGCCAAAAGA
GATGAGTTCCAGTCTGAATACAGGTAGATATTAAAGGGCTAATAAAAAATGAGAAACCGGTCGTCCAAGGTGGATGCTGTCAATGCCCGA
GTGACACATGAGAGCTGTATGAATTGAGAGAAAAGGCAACAAGTAGCATTCTTCATCATTCAAGTTCTACCTGGACACAAAGGCGAGGAC
CCTGGGGTTCCAACAAAGCTCAGCTCCCAGATTCTCTTTCCAGTTTCATCCTAAGTTCCTAGCATAAACACTATTTATTTTCTGCAGCAG
TGTGTTATTTTTGCGCACTTATACAAAATGGTAGTACTACTGTGTTGTGGTTTTTAAACATTAAACATGTAAAGTTATATACGAAATATC
TGCTTTTGGAATAAGCAGAATGAGGCTAAACATGGGTTATACAAAGGGTATCTGGAAACTGAAGAGCAACTTGTTAGAAAACTGACAATG
TCGCAAGATGTACTCAGTTTTGTTTCTGTGTGACATGCAATGGCAACTCATGTGGACACTATTGAAGGGATGTGACATTACCTCCTGTAG
ATATGCTAACAGTGTTATTCTTTCATTTCCAAGGGTTCTCTGTGGCTTTGTGTATATGTTTCCCAGAGGTCATTTGATTACCTAATTTAC
TGAACTGATTTAGCAGGGAATGGAATCCATTCCAACTATTGCACGTGGATTTCCCAGCTGCCCCTAAATATATATACTTGTGAGTGGCAA
AGTGGCACTAATGAAGCTTTTGCCTTTTGTACATTTGAGATTTTTGTATATAGTGTTTGCTGCAAGGCCTGTGGAATTAATTCGTTGCAT
ATAGAGGTATCAACTGCTGCATGTTCAGGCATATTATAAAACTTTAGTCTATGAAAGAATAATTATAATAATGTCCAGGTGCAATACTCT
GTAAGTCTATTGGTTCAAGTTACCGAGAGATAGGTGTGTTCCTTTATGGGGGATGGGGGGGTGTGTTGGGGATTCTTTGTATTGTTTATT
TCATTTTGGTTTATTTTAAAAGATGTAAACATATATTAAGCTATATTAAATCTCACATACAGTTCTTCTGTGCTCTATTATACCCTGATA
GAGATGGGGGAGAGAAAGGAATGTTTTTGATGGTGGTTTCAAAGCTCGGACAGTAACTATCTTGAGCCCATTAGAGAGTCTGTGTCCATA
TTTGCATCTGGCTGGTCATAGCCTTTGTTACTAATGATGACATTCAGTTCTCTTTTGTTTTTATTTTTTAAAAACTCAGGTGTAATTATT
ATCTGTTCTTAAGATAATTGCAAATATTAAATATTATGATATATCAATTCATGTGTTTGGCATACCAGTGAATGATGAAGAACATGAGAT
TAATTTAATTTATCTTCGGTAACTTGACATTCTGGAGAGAGACTATCTTCTGGAGTTGAGTACAAGCACAGAAACATCTTTACGGTGGCA
TCATCTCATTTTTTAGGAAGACATGATAATACTGCCCATCATATTCATGTGTAACTACTGTTCTTTCTTCTGCTTTCTTCACCATAATAA
ACTTTGGACAACCAAGCAAGCTCTAACCGCAATGCCAGATGGCCTTGTCCGAGGGCCTAGTGTTTGCACGGCAGTGGGAACTGGGCCTTT
CCTACAGGACAACTGGCAAGTTTGCTGGGAAGTCAAATAATACATTCCACCTGGCAGCTGAAGGCAGCCAGTCAGTCTGTCCCAGAAAGG
GCCCTTTTCAGCACCCAAAGCTGGGCTGGCTGGGATGCCTCTGGCTGGTGAAGTTCTCACATAGGCTGATTTAAATCCAGCAAAGGTCTA
TAGAAAAAGGCTTGCGTGTTCGTTGAGTAATCATTGTTTCATTTTCATTTTTACGAGAGTTTGAAAATAGACACACTGTTAACACTTCTG
CCAGTTTTTTCTGATCTTTCCAGCCCCACCCCCTTTCTCTTTCTCTCTCTCTCTCAAAGAAAAAAAAAATGGGAGTGCAAAAAAAACAAA
GCCAAAAAATATATGAAGGATAGCTGTTCTTCTGTGTTCTCTCATTATGGACTTTGTGAAGTAGAAACATAATTTTTTTTCCTCCAAAGG
TGAAAAAACAATGCATTCTTGCTTTAAAAAAAAAAAAGAAGGCTAAAAAATTACCTCTTTTTAAATTATGTGCAAAATAATTCTGGCTAA
CTGTAAAATGTATTCAATTTTAGGATTTTTTTTTTTTGTATTGTGATGCTTTATTTGTACATTTTTTTCCTTTCTGGATGTAATTTTAAT
CTCTTGCCATTCATTAGTGTTATTTCATTGTAAACGTTATTGTGCCAAATGTACTGTATTCAAAAGGATGTGAATGTGTATTGTTTCAGA

>10242_10242_3_BRE-PRKCE_BRE_chr2_28268666_ENST00000361704_PRKCE_chr2_46313347_ENST00000306156_length(amino acids)=448AA_BP=190
MSPEVALNRISPMLSPFISSVVRNGKVGLDATNCLRITDLKSGCTSLTPGPNCDRFKLHIPYAGETLKWDIIFNAQYPELPPDFIFGEDA
EFLPDPSALQNLASWNPSNPECLLLVVKELVQQYHQFQCSRLRESSRLMFEYQTLLEEPQYGENMEIYAGKKNNWTGEFSARFLLKLPVD
FSNIPTYLLKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGIL
NGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKR

--------------------------------------------------------------
>10242_10242_4_BRE-PRKCE_BRE_chr2_28268666_ENST00000379624_PRKCE_chr2_46313347_ENST00000306156_length(transcript)=4573nt_BP=687nt
GCGGCGCGCGCGCAGGTCGGTGCGTCTGTCGGGGGCGCGCTCGGGTACCTGTACCCCACGTAGTCGCCGGTTACCGATCGGACTAAGTTC
CAGTGGTGATTTACAAGTCAAGTTAAAATGTCCCCAGAAGTGGCCTTGAACCGAATATCTCCAATGCTCTCCCCTTTCATATCTAGCGTG
GTCCGGAATGGAAAAGTGGGACTGGATGCTACAAACTGTTTGAGGATAACTGACTTAAAATCTGGCTGCACATCATTGACTCCTGGGCCC
AACTGTGACCGATTTAAACTGCACATACCATATGCTGGAGAGACATTAAAGTGGGATATCATTTTCAATGCCCAATACCCAGAACTGCCT
CCCGATTTTATCTTTGGAGAAGATGCTGAATTCCTGCCAGACCCCTCAGCTTTGCAGAATCTTGCCTCCTGGAATCCTTCAAATCCTGAA
TGTCTCTTACTTGTGGTGAAGGAACTTGTGCAACAATATCACCAATTCCAATGTAGCCGCCTCCGGGAGAGCTCCCGCCTCATGTTTGAA
TACCAGACATTACTGGAGGAGCCACAGTATGGAGAGAACATGGAAATTTATGCTGGGAAAAAAAACAACTGGACTGGTGAATTTTCAGCT
CGTTTCCTTTTGAAGCTGCCCGTAGATTTCAGCAATATCCCCACATACCTTCTCAAGGACCGCCTCTTTTTCGTCATGGAATATGTAAAT
GGTGGAGACCTCATGTTTCAGATTCAGCGCTCCCGAAAATTCGACGAGCCTCGTTCACGGTTCTATGCTGCAGAGGTCACATCGGCCCTC
ATGTTCCTCCACCAGCATGGAGTCATCTACAGGGATTTGAAACTGGACAACATCCTTCTGGATGCAGAAGGTCACTGCAAGCTGGCTGAC
TTCGGGATGTGCAAGGAAGGGATTCTGAATGGTGTGACGACCACCACGTTCTGTGGGACTCCTGACTACATAGCTCCTGAGATCCTGCAG
GAGTTGGAGTATGGCCCCTCCGTGGACTGGTGGGCCCTGGGGGTGCTGATGTACGAGATGATGGCTGGACAGCCTCCCTTTGAGGCCGAC
AATGAGGACGACCTATTTGAGTCCATCCTCCATGACGACGTGCTGTACCCAGTCTGGCTCAGCAAGGAGGCTGTCAGCATCTTGAAAGCT
TTCATGACGAAGAATCCCCACAAGCGCCTGGGCTGTGTGGCATCGCAGAATGGCGAGGACGCCATCAAGCAGCACCCATTCTTCAAAGAG
ATTGACTGGGTGCTCCTGGAGCAGAAGAAGATCAAGCCACCCTTCAAACCACGCATTAAAACCAAAAGAGACGTCAATAATTTTGACCAA
GACTTTACCCGGGAAGAGCCGGTACTCACCCTTGTGGACGAAGCAATTGTAAAGCAGATCAACCAGGAGGAATTCAAAGGTTTCTCCTAC
TTTGGTGAAGACCTGATGCCCTGAGAGCCCACTGCAGTTGGACTTTGCCGATGCTGCAAGAAGGGGTGCAGAGAAGACTCCTGTGTTGGA
GACACTCAGCAGGTCTTGAACTACTTCTCCTCCTCGGAGCCCCAGTCCCATGTCCACTGTCTATTTATTGCATTCCCTTGCCCCAGGCCA
CCTCCTCCCCCTCCCACCTGGTGACCAGAAGGCGCTCTCGGTTCTTGTCTCACCAGTAATGCAGACTCATTGGGTCAGCAATTAGCTGTA
TACACTGCCGTGTTTGGACCATTGGCAAGCCTGGTTCCACTCCTCAGGGGCTCCTGGCAGTGAAGCAACTTCAGTTCTTTTACTGCAAAG
AACAGAAAAAAGAAAGAAAGCAAACAAGAAGACTCCGGCTCTGCTATCGGACACAGATCCTGATCCCTCTTGCTTCTTTTCCCTCCTGCA
CCGCAGCTTGCCATCCCTGCCCTTCTGTCCTGGAGAAGAGACTGGTGCTTCTCCGCACACACGAGGGAGGGCGCCCTTGAGGCATGCCCT
CTGAGGGAGGGAGACCAGAGATGCAGGGATTGGCCAGCTGGGTTGGTTTGCTCTGGAATGGCTAACTCTTGCCTGCTTTGGTTTTAGCTT
TTCAGCATGCCAAAGTCATGTAAGTTTGTGTCTTGTGGAAGAAATCCTCTTTGTGGAAAAAGAAACAGGGTTTTGAACTCTGTTAACATT
TGAAAAATATATTTTCAAATTCACTTTCTAATTGGCCAAAAGAGATGAGTTCCAGTCTGAATACAGGTAGATATTAAAGGGCTAATAAAA
AATGAGAAACCGGTCGTCCAAGGTGGATGCTGTCAATGCCCGAGTGACACATGAGAGCTGTATGAATTGAGAGAAAAGGCAACAAGTAGC
ATTCTTCATCATTCAAGTTCTACCTGGACACAAAGGCGAGGACCCTGGGGTTCCAACAAAGCTCAGCTCCCAGATTCTCTTTCCAGTTTC
ATCCTAAGTTCCTAGCATAAACACTATTTATTTTCTGCAGCAGTGTGTTATTTTTGCGCACTTATACAAAATGGTAGTACTACTGTGTTG
TGGTTTTTAAACATTAAACATGTAAAGTTATATACGAAATATCTGCTTTTGGAATAAGCAGAATGAGGCTAAACATGGGTTATACAAAGG
GTATCTGGAAACTGAAGAGCAACTTGTTAGAAAACTGACAATGTCGCAAGATGTACTCAGTTTTGTTTCTGTGTGACATGCAATGGCAAC
TCATGTGGACACTATTGAAGGGATGTGACATTACCTCCTGTAGATATGCTAACAGTGTTATTCTTTCATTTCCAAGGGTTCTCTGTGGCT
TTGTGTATATGTTTCCCAGAGGTCATTTGATTACCTAATTTACTGAACTGATTTAGCAGGGAATGGAATCCATTCCAACTATTGCACGTG
GATTTCCCAGCTGCCCCTAAATATATATACTTGTGAGTGGCAAAGTGGCACTAATGAAGCTTTTGCCTTTTGTACATTTGAGATTTTTGT
ATATAGTGTTTGCTGCAAGGCCTGTGGAATTAATTCGTTGCATATAGAGGTATCAACTGCTGCATGTTCAGGCATATTATAAAACTTTAG
TCTATGAAAGAATAATTATAATAATGTCCAGGTGCAATACTCTGTAAGTCTATTGGTTCAAGTTACCGAGAGATAGGTGTGTTCCTTTAT
GGGGGATGGGGGGGTGTGTTGGGGATTCTTTGTATTGTTTATTTCATTTTGGTTTATTTTAAAAGATGTAAACATATATTAAGCTATATT
AAATCTCACATACAGTTCTTCTGTGCTCTATTATACCCTGATAGAGATGGGGGAGAGAAAGGAATGTTTTTGATGGTGGTTTCAAAGCTC
GGACAGTAACTATCTTGAGCCCATTAGAGAGTCTGTGTCCATATTTGCATCTGGCTGGTCATAGCCTTTGTTACTAATGATGACATTCAG
TTCTCTTTTGTTTTTATTTTTTAAAAACTCAGGTGTAATTATTATCTGTTCTTAAGATAATTGCAAATATTAAATATTATGATATATCAA
TTCATGTGTTTGGCATACCAGTGAATGATGAAGAACATGAGATTAATTTAATTTATCTTCGGTAACTTGACATTCTGGAGAGAGACTATC
TTCTGGAGTTGAGTACAAGCACAGAAACATCTTTACGGTGGCATCATCTCATTTTTTAGGAAGACATGATAATACTGCCCATCATATTCA
TGTGTAACTACTGTTCTTTCTTCTGCTTTCTTCACCATAATAAACTTTGGACAACCAAGCAAGCTCTAACCGCAATGCCAGATGGCCTTG
TCCGAGGGCCTAGTGTTTGCACGGCAGTGGGAACTGGGCCTTTCCTACAGGACAACTGGCAAGTTTGCTGGGAAGTCAAATAATACATTC
CACCTGGCAGCTGAAGGCAGCCAGTCAGTCTGTCCCAGAAAGGGCCCTTTTCAGCACCCAAAGCTGGGCTGGCTGGGATGCCTCTGGCTG
GTGAAGTTCTCACATAGGCTGATTTAAATCCAGCAAAGGTCTATAGAAAAAGGCTTGCGTGTTCGTTGAGTAATCATTGTTTCATTTTCA
TTTTTACGAGAGTTTGAAAATAGACACACTGTTAACACTTCTGCCAGTTTTTTCTGATCTTTCCAGCCCCACCCCCTTTCTCTTTCTCTC
TCTCTCTCAAAGAAAAAAAAAATGGGAGTGCAAAAAAAACAAAGCCAAAAAATATATGAAGGATAGCTGTTCTTCTGTGTTCTCTCATTA
TGGACTTTGTGAAGTAGAAACATAATTTTTTTTCCTCCAAAGGTGAAAAAACAATGCATTCTTGCTTTAAAAAAAAAAAAGAAGGCTAAA
AAATTACCTCTTTTTAAATTATGTGCAAAATAATTCTGGCTAACTGTAAAATGTATTCAATTTTAGGATTTTTTTTTTTTGTATTGTGAT
GCTTTATTTGTACATTTTTTTCCTTTCTGGATGTAATTTTAATCTCTTGCCATTCATTAGTGTTATTTCATTGTAAACGTTATTGTGCCA

>10242_10242_4_BRE-PRKCE_BRE_chr2_28268666_ENST00000379624_PRKCE_chr2_46313347_ENST00000306156_length(amino acids)=448AA_BP=190
MSPEVALNRISPMLSPFISSVVRNGKVGLDATNCLRITDLKSGCTSLTPGPNCDRFKLHIPYAGETLKWDIIFNAQYPELPPDFIFGEDA
EFLPDPSALQNLASWNPSNPECLLLVVKELVQQYHQFQCSRLRESSRLMFEYQTLLEEPQYGENMEIYAGKKNNWTGEFSARFLLKLPVD
FSNIPTYLLKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGIL
NGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKR

--------------------------------------------------------------
>10242_10242_5_BRE-PRKCE_BRE_chr2_28268666_ENST00000379632_PRKCE_chr2_46313347_ENST00000306156_length(transcript)=4596nt_BP=710nt
GGTACCTGTACCCCACGTAGTCGCCGGTTACCGATCGGACTAAGTTCCAGAAGCAAGAGATAAAGTAATAATGGGTACTGTGGGGAAAAA
CACAGAAGAACAATTCGGTAATATAGTGGTGATTTACAAGTCAAGTTAAAATGTCCCCAGAAGTGGCCTTGAACCGAATATCTCCAATGC
TCTCCCCTTTCATATCTAGCGTGGTCCGGAATGGAAAAGTGGGACTGGATGCTACAAACTGTTTGAGGATAACTGACTTAAAATCTGGCT
GCACATCATTGACTCCTGGGCCCAACTGTGACCGATTTAAACTGCACATACCATATGCTGGAGAGACATTAAAGTGGGATATCATTTTCA
ATGCCCAATACCCAGAACTGCCTCCCGATTTTATCTTTGGAGAAGATGCTGAATTCCTGCCAGACCCCTCAGCTTTGCAGAATCTTGCCT
CCTGGAATCCTTCAAATCCTGAATGTCTCTTACTTGTGGTGAAGGAACTTGTGCAACAATATCACCAATTCCAATGTAGCCGCCTCCGGG
AGAGCTCCCGCCTCATGTTTGAATACCAGACATTACTGGAGGAGCCACAGTATGGAGAGAACATGGAAATTTATGCTGGGAAAAAAAACA
ACTGGACTGGTGAATTTTCAGCTCGTTTCCTTTTGAAGCTGCCCGTAGATTTCAGCAATATCCCCACATACCTTCTCAAGGACCGCCTCT
TTTTCGTCATGGAATATGTAAATGGTGGAGACCTCATGTTTCAGATTCAGCGCTCCCGAAAATTCGACGAGCCTCGTTCACGGTTCTATG
CTGCAGAGGTCACATCGGCCCTCATGTTCCTCCACCAGCATGGAGTCATCTACAGGGATTTGAAACTGGACAACATCCTTCTGGATGCAG
AAGGTCACTGCAAGCTGGCTGACTTCGGGATGTGCAAGGAAGGGATTCTGAATGGTGTGACGACCACCACGTTCTGTGGGACTCCTGACT
ACATAGCTCCTGAGATCCTGCAGGAGTTGGAGTATGGCCCCTCCGTGGACTGGTGGGCCCTGGGGGTGCTGATGTACGAGATGATGGCTG
GACAGCCTCCCTTTGAGGCCGACAATGAGGACGACCTATTTGAGTCCATCCTCCATGACGACGTGCTGTACCCAGTCTGGCTCAGCAAGG
AGGCTGTCAGCATCTTGAAAGCTTTCATGACGAAGAATCCCCACAAGCGCCTGGGCTGTGTGGCATCGCAGAATGGCGAGGACGCCATCA
AGCAGCACCCATTCTTCAAAGAGATTGACTGGGTGCTCCTGGAGCAGAAGAAGATCAAGCCACCCTTCAAACCACGCATTAAAACCAAAA
GAGACGTCAATAATTTTGACCAAGACTTTACCCGGGAAGAGCCGGTACTCACCCTTGTGGACGAAGCAATTGTAAAGCAGATCAACCAGG
AGGAATTCAAAGGTTTCTCCTACTTTGGTGAAGACCTGATGCCCTGAGAGCCCACTGCAGTTGGACTTTGCCGATGCTGCAAGAAGGGGT
GCAGAGAAGACTCCTGTGTTGGAGACACTCAGCAGGTCTTGAACTACTTCTCCTCCTCGGAGCCCCAGTCCCATGTCCACTGTCTATTTA
TTGCATTCCCTTGCCCCAGGCCACCTCCTCCCCCTCCCACCTGGTGACCAGAAGGCGCTCTCGGTTCTTGTCTCACCAGTAATGCAGACT
CATTGGGTCAGCAATTAGCTGTATACACTGCCGTGTTTGGACCATTGGCAAGCCTGGTTCCACTCCTCAGGGGCTCCTGGCAGTGAAGCA
ACTTCAGTTCTTTTACTGCAAAGAACAGAAAAAAGAAAGAAAGCAAACAAGAAGACTCCGGCTCTGCTATCGGACACAGATCCTGATCCC
TCTTGCTTCTTTTCCCTCCTGCACCGCAGCTTGCCATCCCTGCCCTTCTGTCCTGGAGAAGAGACTGGTGCTTCTCCGCACACACGAGGG
AGGGCGCCCTTGAGGCATGCCCTCTGAGGGAGGGAGACCAGAGATGCAGGGATTGGCCAGCTGGGTTGGTTTGCTCTGGAATGGCTAACT
CTTGCCTGCTTTGGTTTTAGCTTTTCAGCATGCCAAAGTCATGTAAGTTTGTGTCTTGTGGAAGAAATCCTCTTTGTGGAAAAAGAAACA
GGGTTTTGAACTCTGTTAACATTTGAAAAATATATTTTCAAATTCACTTTCTAATTGGCCAAAAGAGATGAGTTCCAGTCTGAATACAGG
TAGATATTAAAGGGCTAATAAAAAATGAGAAACCGGTCGTCCAAGGTGGATGCTGTCAATGCCCGAGTGACACATGAGAGCTGTATGAAT
TGAGAGAAAAGGCAACAAGTAGCATTCTTCATCATTCAAGTTCTACCTGGACACAAAGGCGAGGACCCTGGGGTTCCAACAAAGCTCAGC
TCCCAGATTCTCTTTCCAGTTTCATCCTAAGTTCCTAGCATAAACACTATTTATTTTCTGCAGCAGTGTGTTATTTTTGCGCACTTATAC
AAAATGGTAGTACTACTGTGTTGTGGTTTTTAAACATTAAACATGTAAAGTTATATACGAAATATCTGCTTTTGGAATAAGCAGAATGAG
GCTAAACATGGGTTATACAAAGGGTATCTGGAAACTGAAGAGCAACTTGTTAGAAAACTGACAATGTCGCAAGATGTACTCAGTTTTGTT
TCTGTGTGACATGCAATGGCAACTCATGTGGACACTATTGAAGGGATGTGACATTACCTCCTGTAGATATGCTAACAGTGTTATTCTTTC
ATTTCCAAGGGTTCTCTGTGGCTTTGTGTATATGTTTCCCAGAGGTCATTTGATTACCTAATTTACTGAACTGATTTAGCAGGGAATGGA
ATCCATTCCAACTATTGCACGTGGATTTCCCAGCTGCCCCTAAATATATATACTTGTGAGTGGCAAAGTGGCACTAATGAAGCTTTTGCC
TTTTGTACATTTGAGATTTTTGTATATAGTGTTTGCTGCAAGGCCTGTGGAATTAATTCGTTGCATATAGAGGTATCAACTGCTGCATGT
TCAGGCATATTATAAAACTTTAGTCTATGAAAGAATAATTATAATAATGTCCAGGTGCAATACTCTGTAAGTCTATTGGTTCAAGTTACC
GAGAGATAGGTGTGTTCCTTTATGGGGGATGGGGGGGTGTGTTGGGGATTCTTTGTATTGTTTATTTCATTTTGGTTTATTTTAAAAGAT
GTAAACATATATTAAGCTATATTAAATCTCACATACAGTTCTTCTGTGCTCTATTATACCCTGATAGAGATGGGGGAGAGAAAGGAATGT
TTTTGATGGTGGTTTCAAAGCTCGGACAGTAACTATCTTGAGCCCATTAGAGAGTCTGTGTCCATATTTGCATCTGGCTGGTCATAGCCT
TTGTTACTAATGATGACATTCAGTTCTCTTTTGTTTTTATTTTTTAAAAACTCAGGTGTAATTATTATCTGTTCTTAAGATAATTGCAAA
TATTAAATATTATGATATATCAATTCATGTGTTTGGCATACCAGTGAATGATGAAGAACATGAGATTAATTTAATTTATCTTCGGTAACT
TGACATTCTGGAGAGAGACTATCTTCTGGAGTTGAGTACAAGCACAGAAACATCTTTACGGTGGCATCATCTCATTTTTTAGGAAGACAT
GATAATACTGCCCATCATATTCATGTGTAACTACTGTTCTTTCTTCTGCTTTCTTCACCATAATAAACTTTGGACAACCAAGCAAGCTCT
AACCGCAATGCCAGATGGCCTTGTCCGAGGGCCTAGTGTTTGCACGGCAGTGGGAACTGGGCCTTTCCTACAGGACAACTGGCAAGTTTG
CTGGGAAGTCAAATAATACATTCCACCTGGCAGCTGAAGGCAGCCAGTCAGTCTGTCCCAGAAAGGGCCCTTTTCAGCACCCAAAGCTGG
GCTGGCTGGGATGCCTCTGGCTGGTGAAGTTCTCACATAGGCTGATTTAAATCCAGCAAAGGTCTATAGAAAAAGGCTTGCGTGTTCGTT
GAGTAATCATTGTTTCATTTTCATTTTTACGAGAGTTTGAAAATAGACACACTGTTAACACTTCTGCCAGTTTTTTCTGATCTTTCCAGC
CCCACCCCCTTTCTCTTTCTCTCTCTCTCTCAAAGAAAAAAAAAATGGGAGTGCAAAAAAAACAAAGCCAAAAAATATATGAAGGATAGC
TGTTCTTCTGTGTTCTCTCATTATGGACTTTGTGAAGTAGAAACATAATTTTTTTTCCTCCAAAGGTGAAAAAACAATGCATTCTTGCTT
TAAAAAAAAAAAAGAAGGCTAAAAAATTACCTCTTTTTAAATTATGTGCAAAATAATTCTGGCTAACTGTAAAATGTATTCAATTTTAGG
ATTTTTTTTTTTTGTATTGTGATGCTTTATTTGTACATTTTTTTCCTTTCTGGATGTAATTTTAATCTCTTGCCATTCATTAGTGTTATT
TCATTGTAAACGTTATTGTGCCAAATGTACTGTATTCAAAAGGATGTGAATGTGTATTGTTTCAGAACCTAATAAATACAATGACGTTAA

>10242_10242_5_BRE-PRKCE_BRE_chr2_28268666_ENST00000379632_PRKCE_chr2_46313347_ENST00000306156_length(amino acids)=448AA_BP=190
MSPEVALNRISPMLSPFISSVVRNGKVGLDATNCLRITDLKSGCTSLTPGPNCDRFKLHIPYAGETLKWDIIFNAQYPELPPDFIFGEDA
EFLPDPSALQNLASWNPSNPECLLLVVKELVQQYHQFQCSRLRESSRLMFEYQTLLEEPQYGENMEIYAGKKNNWTGEFSARFLLKLPVD
FSNIPTYLLKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGIL
NGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKR

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Fusion Gene PPI Analysis for BRE-PRKCE


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BRE-PRKCE


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BRE-PRKCE


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource