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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF584-AKAP9 (FusionGDB2 ID:102442)

Fusion Gene Summary for ZNF584-AKAP9

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF584-AKAP9
Fusion gene ID: 102442
HgeneTgene
Gene symbol

ZNF584

AKAP9

Gene ID

201514

10142

Gene namezinc finger protein 584A-kinase anchoring protein 9
Synonyms-AKAP-9|AKAP350|AKAP450|CG-NAP|HYPERION|LQT11|MU-RMS-40.16A|PPP1R45|PRKA9|YOTIAO
Cytomap

19q13.43

7q21.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 584A-kinase anchor protein 9A kinase (PRKA) anchor protein (yotiao) 9A kinase (PRKA) anchor protein 9A-kinase anchor protein 350 kDaA-kinase anchor protein 450 kDaAKAP 120-like proteinAKAP9-BRAF fusion proteincentrosome- and Golgi-localized PKN-associ
Modification date2020031320200328
UniProtAcc.

Q99996

Ensembl transtripts involved in fusion geneENST00000306910, ENST00000322834, 
ENST00000593920, ENST00000596281, 
ENST00000596921, ENST00000599238, 
ENST00000356239, ENST00000358100, 
ENST00000359028, ENST00000394564, 
ENST00000491695, 
Fusion gene scores* DoF score4 X 3 X 3=3611 X 17 X 7=1309
# samples 415
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(15/1309*10)=-3.12543069144936
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF584 [Title/Abstract] AND AKAP9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF584(58923875)-AKAP9(91725929), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneAKAP9

GO:0098962

regulation of postsynaptic neurotransmitter receptor activity

10390370

TgeneAKAP9

GO:1903358

regulation of Golgi organization

27666745


check buttonFusion gene breakpoints across ZNF584 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across AKAP9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABM931973ZNF584chr19

58923875

+AKAP9chr7

91725929

+


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Fusion Gene ORF analysis for ZNF584-AKAP9

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000306910ENST00000356239ZNF584chr19

58923875

+AKAP9chr7

91725929

+
intron-intronENST00000306910ENST00000358100ZNF584chr19

58923875

+AKAP9chr7

91725929

+
intron-intronENST00000306910ENST00000359028ZNF584chr19

58923875

+AKAP9chr7

91725929

+
intron-intronENST00000306910ENST00000394564ZNF584chr19

58923875

+AKAP9chr7

91725929

+
intron-intronENST00000306910ENST00000491695ZNF584chr19

58923875

+AKAP9chr7

91725929

+
intron-intronENST00000322834ENST00000356239ZNF584chr19

58923875

+AKAP9chr7

91725929

+
intron-intronENST00000322834ENST00000358100ZNF584chr19

58923875

+AKAP9chr7

91725929

+
intron-intronENST00000322834ENST00000359028ZNF584chr19

58923875

+AKAP9chr7

91725929

+
intron-intronENST00000322834ENST00000394564ZNF584chr19

58923875

+AKAP9chr7

91725929

+
intron-intronENST00000322834ENST00000491695ZNF584chr19

58923875

+AKAP9chr7

91725929

+
intron-intronENST00000593920ENST00000356239ZNF584chr19

58923875

+AKAP9chr7

91725929

+
intron-intronENST00000593920ENST00000358100ZNF584chr19

58923875

+AKAP9chr7

91725929

+
intron-intronENST00000593920ENST00000359028ZNF584chr19

58923875

+AKAP9chr7

91725929

+
intron-intronENST00000593920ENST00000394564ZNF584chr19

58923875

+AKAP9chr7

91725929

+
intron-intronENST00000593920ENST00000491695ZNF584chr19

58923875

+AKAP9chr7

91725929

+
intron-intronENST00000596281ENST00000356239ZNF584chr19

58923875

+AKAP9chr7

91725929

+
intron-intronENST00000596281ENST00000358100ZNF584chr19

58923875

+AKAP9chr7

91725929

+
intron-intronENST00000596281ENST00000359028ZNF584chr19

58923875

+AKAP9chr7

91725929

+
intron-intronENST00000596281ENST00000394564ZNF584chr19

58923875

+AKAP9chr7

91725929

+
intron-intronENST00000596281ENST00000491695ZNF584chr19

58923875

+AKAP9chr7

91725929

+
intron-intronENST00000596921ENST00000356239ZNF584chr19

58923875

+AKAP9chr7

91725929

+
intron-intronENST00000596921ENST00000358100ZNF584chr19

58923875

+AKAP9chr7

91725929

+
intron-intronENST00000596921ENST00000359028ZNF584chr19

58923875

+AKAP9chr7

91725929

+
intron-intronENST00000596921ENST00000394564ZNF584chr19

58923875

+AKAP9chr7

91725929

+
intron-intronENST00000596921ENST00000491695ZNF584chr19

58923875

+AKAP9chr7

91725929

+
intron-intronENST00000599238ENST00000356239ZNF584chr19

58923875

+AKAP9chr7

91725929

+
intron-intronENST00000599238ENST00000358100ZNF584chr19

58923875

+AKAP9chr7

91725929

+
intron-intronENST00000599238ENST00000359028ZNF584chr19

58923875

+AKAP9chr7

91725929

+
intron-intronENST00000599238ENST00000394564ZNF584chr19

58923875

+AKAP9chr7

91725929

+
intron-intronENST00000599238ENST00000491695ZNF584chr19

58923875

+AKAP9chr7

91725929

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ZNF584-AKAP9


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF584-AKAP9


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:58923875/:91725929)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.AKAP9

Q99996

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Required to maintain the integrity of the Golgi apparatus (PubMed:10202149, PubMed:15047863). Required for microtubule nucleation at the cis-side of the Golgi apparatus (PubMed:15047863, PubMed:19242490). Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase (PubMed:25657325). In complex with PDE4DIP isoform 13/MMG8/SMYLE, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with PDE4DIP isoform 13/MMG8/SMYLE, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension also from the centrosome to the cell periphery (PubMed:29162697). {ECO:0000269|PubMed:10202149, ECO:0000269|PubMed:15047863, ECO:0000269|PubMed:19242490, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:29162697}.; FUNCTION: [Isoform 4]: Associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations. {ECO:0000269|PubMed:9482789}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ZNF584-AKAP9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ZNF584-AKAP9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF584-AKAP9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF584-AKAP9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource