Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ZNF585A-CACNA1G (FusionGDB2 ID:102446)

Fusion Gene Summary for ZNF585A-CACNA1G

Fusion gene summary

Fusion gene information	Fusion gene name: ZNF585A-CACNA1G
	Fusion gene ID: 102446
		Hgene	Tgene
	Gene symbol	ZNF585A	CACNA1G
	Gene ID	199704	8913
	Gene name	zinc finger protein 585A	calcium voltage-gated channel subunit alpha1 G
	Synonyms	Zfp27	Ca(V)T.1\|Cav3.1\|NBR13\|SCA42\|SCA42ND
	Cytomap	19q13.12	17q21.33
	Type of gene	protein-coding	protein-coding
	Description	zinc finger protein 585A	voltage-dependent T-type calcium channel subunit alpha-1Gcalcium channel, voltage-dependent, T type, alpha 1G subunitcav3.1cvoltage-dependent T-type calcium channel alpha 1G subunitvoltage-dependent calcium channel alpha 1G subunitvoltage-gated calci
	Modification date	20200313	20200313
	UniProtAcc	.	O43497
	Ensembl transtripts involved in fusion gene	ENST00000292841, ENST00000355533, ENST00000392157, ENST00000588723, ENST00000356958, ENST00000588354,	ENST00000352832, ENST00000354983, ENST00000358244, ENST00000359106, ENST00000360761, ENST00000416767, ENST00000429973, ENST00000442258, ENST00000502264, ENST00000503485, ENST00000505165, ENST00000507336, ENST00000507510, ENST00000507609, ENST00000507896, ENST00000510115, ENST00000510366, ENST00000512389, ENST00000513689, ENST00000513964, ENST00000514079, ENST00000514181, ENST00000514717, ENST00000515165, ENST00000515411, ENST00000515765,
Fusion gene scores	* DoF score	6 X 6 X 5=180	6 X 4 X 5=120
	# samples	6	5
	** MAII score	log2(6/180*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/120*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ZNF585A [Title/Abstract] AND CACNA1G [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ZNF585A(37660741)-CACNA1G(48652904), # samples:1
Anticipated loss of major functional domain due to fusion event.	ZNF585A-CACNA1G seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. ZNF585A-CACNA1G seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. ZNF585A-CACNA1G seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CACNA1G	GO:0042391	regulation of membrane potential	21084288
Tgene	CACNA1G	GO:0070509	calcium ion import	21084288
Tgene	CACNA1G	GO:0070588	calcium ion transmembrane transport	26456284\|26715324

Fusion gene breakpoints across ZNF585A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CACNA1G (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-69-A59K-01A	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+

Top

Fusion Gene ORF analysis for ZNF585A-CACNA1G

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000292841	ENST00000352832	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000292841	ENST00000354983	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000292841	ENST00000358244	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000292841	ENST00000359106	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000292841	ENST00000360761	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000292841	ENST00000416767	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000292841	ENST00000429973	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000292841	ENST00000442258	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000292841	ENST00000502264	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000292841	ENST00000503485	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000292841	ENST00000505165	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000292841	ENST00000507336	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000292841	ENST00000507510	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000292841	ENST00000507609	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000292841	ENST00000507896	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000292841	ENST00000510115	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000292841	ENST00000510366	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000292841	ENST00000512389	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000292841	ENST00000513689	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000292841	ENST00000513964	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000292841	ENST00000514079	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000292841	ENST00000514181	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000292841	ENST00000514717	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000292841	ENST00000515165	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000292841	ENST00000515411	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000292841	ENST00000515765	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000355533	ENST00000352832	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000355533	ENST00000354983	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000355533	ENST00000358244	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000355533	ENST00000359106	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000355533	ENST00000360761	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000355533	ENST00000416767	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000355533	ENST00000429973	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000355533	ENST00000442258	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000355533	ENST00000502264	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000355533	ENST00000503485	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000355533	ENST00000505165	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000355533	ENST00000507336	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000355533	ENST00000507510	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000355533	ENST00000507609	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000355533	ENST00000507896	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000355533	ENST00000510115	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000355533	ENST00000510366	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000355533	ENST00000512389	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000355533	ENST00000513689	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000355533	ENST00000513964	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000355533	ENST00000514079	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000355533	ENST00000514181	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000355533	ENST00000514717	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000355533	ENST00000515165	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000355533	ENST00000515411	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000355533	ENST00000515765	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000392157	ENST00000352832	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000392157	ENST00000354983	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000392157	ENST00000358244	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000392157	ENST00000359106	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000392157	ENST00000360761	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000392157	ENST00000416767	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000392157	ENST00000429973	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000392157	ENST00000442258	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000392157	ENST00000502264	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000392157	ENST00000503485	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000392157	ENST00000505165	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000392157	ENST00000507336	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000392157	ENST00000507510	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000392157	ENST00000507609	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000392157	ENST00000507896	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000392157	ENST00000510115	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000392157	ENST00000510366	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000392157	ENST00000512389	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000392157	ENST00000513689	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000392157	ENST00000513964	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000392157	ENST00000514079	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000392157	ENST00000514181	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000392157	ENST00000514717	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000392157	ENST00000515165	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000392157	ENST00000515411	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000392157	ENST00000515765	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000588723	ENST00000352832	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000588723	ENST00000354983	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000588723	ENST00000358244	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000588723	ENST00000359106	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000588723	ENST00000360761	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000588723	ENST00000416767	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000588723	ENST00000429973	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000588723	ENST00000442258	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000588723	ENST00000502264	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000588723	ENST00000503485	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000588723	ENST00000505165	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000588723	ENST00000507336	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000588723	ENST00000507510	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000588723	ENST00000507609	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000588723	ENST00000507896	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000588723	ENST00000510115	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000588723	ENST00000510366	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000588723	ENST00000512389	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000588723	ENST00000513689	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000588723	ENST00000513964	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000588723	ENST00000514079	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000588723	ENST00000514181	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000588723	ENST00000514717	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000588723	ENST00000515165	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000588723	ENST00000515411	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
5UTR-3CDS	ENST00000588723	ENST00000515765	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000356958	ENST00000352832	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000356958	ENST00000354983	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000356958	ENST00000358244	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000356958	ENST00000359106	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000356958	ENST00000360761	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000356958	ENST00000416767	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000356958	ENST00000429973	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000356958	ENST00000442258	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000356958	ENST00000502264	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000356958	ENST00000503485	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000356958	ENST00000505165	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000356958	ENST00000507336	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000356958	ENST00000507510	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000356958	ENST00000507609	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000356958	ENST00000507896	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000356958	ENST00000510115	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000356958	ENST00000510366	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000356958	ENST00000512389	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000356958	ENST00000513689	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000356958	ENST00000513964	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000356958	ENST00000514079	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000356958	ENST00000514181	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000356958	ENST00000514717	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000356958	ENST00000515165	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000356958	ENST00000515411	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000356958	ENST00000515765	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000588354	ENST00000352832	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000588354	ENST00000354983	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000588354	ENST00000358244	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000588354	ENST00000359106	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000588354	ENST00000360761	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000588354	ENST00000416767	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000588354	ENST00000429973	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000588354	ENST00000442258	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000588354	ENST00000502264	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000588354	ENST00000503485	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000588354	ENST00000505165	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000588354	ENST00000507336	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000588354	ENST00000507510	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000588354	ENST00000507609	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000588354	ENST00000507896	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000588354	ENST00000510115	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000588354	ENST00000510366	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000588354	ENST00000512389	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000588354	ENST00000513689	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000588354	ENST00000513964	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000588354	ENST00000514079	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000588354	ENST00000514181	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000588354	ENST00000514717	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000588354	ENST00000515165	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000588354	ENST00000515411	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+
Frame-shift	ENST00000588354	ENST00000515765	ZNF585A	chr19	37660741	-	CACNA1G	chr17	48652904	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

Top

Fusion Genomic Features for ZNF585A-CACNA1G

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ZNF585A	chr19	37660740	-	CACNA1G	chr17	48652903	+	0.000128046	0.99987197
ZNF585A	chr19	37660740	-	CACNA1G	chr17	48652903	+	0.000128046	0.99987197

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for ZNF585A-CACNA1G

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:37660741/:48652904)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	CACNA1G O43497
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group and are strongly blocked by mibefradil. A particularity of this type of channel is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. {ECO:0000269\|PubMed:10648811, ECO:0000269\|PubMed:10692398, ECO:0000269\|PubMed:26456284, ECO:0000269\|PubMed:26715324, ECO:0000269\|PubMed:29878067}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

Fusion Gene Sequence for ZNF585A-CACNA1G

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for ZNF585A-CACNA1G

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ZNF585A-CACNA1G

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ZNF585A-CACNA1G

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source