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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF586-AATF (FusionGDB2 ID:102455)

Fusion Gene Summary for ZNF586-AATF

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF586-AATF
Fusion gene ID: 102455
HgeneTgene
Gene symbol

ZNF586

AATF

Gene ID

54807

26574

Gene namezinc finger protein 586apoptosis antagonizing transcription factor
Synonyms-BFR2|CHE-1|CHE1|DED
Cytomap

19q13.43

17q12

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 586protein AATFrb-binding protein Che-1
Modification date2020031320200313
UniProtAcc.

Q9NY61

Ensembl transtripts involved in fusion geneENST00000396150, ENST00000396154, 
ENST00000598183, ENST00000598885, 
ENST00000599802, ENST00000391702, 
ENST00000590321, ENST00000225402, 
Fusion gene scores* DoF score6 X 5 X 5=15026 X 13 X 11=3718
# samples 728
** MAII scorelog2(7/150*10)=-1.09953567355091
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(28/3718*10)=-3.73102803797452
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF586 [Title/Abstract] AND AATF [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF586(58281246)-AATF(35413901), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneAATF

GO:0032929

negative regulation of superoxide anion generation

15207272

TgeneAATF

GO:0045944

positive regulation of transcription by RNA polymerase II

18049476

TgeneAATF

GO:2000378

negative regulation of reactive oxygen species metabolic process

15207272


check buttonFusion gene breakpoints across ZNF586 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AATF (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A8BM-01AZNF586chr19

58281246

-AATFchr17

35413901

+
ChimerDB4SARCTCGA-DX-A8BM-01AZNF586chr19

58281246

+AATFchr17

35413901

+


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Fusion Gene ORF analysis for ZNF586-AATF

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000396150ENST00000590321ZNF586chr19

58281246

+AATFchr17

35413901

+
5CDS-3UTRENST00000396154ENST00000590321ZNF586chr19

58281246

+AATFchr17

35413901

+
5CDS-3UTRENST00000598183ENST00000590321ZNF586chr19

58281246

+AATFchr17

35413901

+
5CDS-3UTRENST00000598885ENST00000590321ZNF586chr19

58281246

+AATFchr17

35413901

+
5CDS-3UTRENST00000599802ENST00000590321ZNF586chr19

58281246

+AATFchr17

35413901

+
5UTR-3CDSENST00000391702ENST00000225402ZNF586chr19

58281246

+AATFchr17

35413901

+
5UTR-3UTRENST00000391702ENST00000590321ZNF586chr19

58281246

+AATFchr17

35413901

+
In-frameENST00000396150ENST00000225402ZNF586chr19

58281246

+AATFchr17

35413901

+
In-frameENST00000396154ENST00000225402ZNF586chr19

58281246

+AATFchr17

35413901

+
In-frameENST00000598183ENST00000225402ZNF586chr19

58281246

+AATFchr17

35413901

+
In-frameENST00000598885ENST00000225402ZNF586chr19

58281246

+AATFchr17

35413901

+
In-frameENST00000599802ENST00000225402ZNF586chr19

58281246

+AATFchr17

35413901

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000599802ZNF586chr1958281246+ENST00000225402AATFchr1735413901+48020945711148
ENST00000598885ZNF586chr1958281246+ENST00000225402AATFchr1735413901+48921846620148
ENST00000598183ZNF586chr1958281246+ENST00000225402AATFchr1735413901+48321246014148
ENST00000396154ZNF586chr1958281246+ENST00000225402AATFchr1735413901+48020945711148
ENST00000396150ZNF586chr1958281246+ENST00000225402AATFchr1735413901+4541834310144

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000599802ENST00000225402ZNF586chr1958281246+AATFchr1735413901+0.80657940.19342063
ENST00000598885ENST00000225402ZNF586chr1958281246+AATFchr1735413901+0.804290240.19570974
ENST00000598183ENST00000225402ZNF586chr1958281246+AATFchr1735413901+0.82325710.17674287
ENST00000396154ENST00000225402ZNF586chr1958281246+AATFchr1735413901+0.80657940.19342063
ENST00000396150ENST00000225402ZNF586chr1958281246+AATFchr1735413901+0.85839890.14160107

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Fusion Genomic Features for ZNF586-AATF


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ZNF586chr1958281246+AATFchr1735413900+2.83E-101
ZNF586chr1958281246+AATFchr1735413900+2.83E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ZNF586-AATF


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:58281246/chr17:35413901)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.AATF

Q9NY61

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. {ECO:0000269|PubMed:12450794, ECO:0000269|PubMed:12847090, ECO:0000269|PubMed:14627703, ECO:0000269|PubMed:15207272}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF586chr19:58281246chr17:35413901ENST00000391702+1415_870360.0DomainKRAB
HgeneZNF586chr19:58281246chr17:35413901ENST00000396150+1215_8712211.0DomainKRAB
HgeneZNF586chr19:58281246chr17:35413901ENST00000396154+1315_8712403.0DomainKRAB
HgeneZNF586chr19:58281246chr17:35413901ENST00000391702+14122_1440360.0Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF586chr19:58281246chr17:35413901ENST00000391702+14150_1720360.0Zinc fingerC2H2-type 3%3B degenerate
HgeneZNF586chr19:58281246chr17:35413901ENST00000391702+14178_2000360.0Zinc fingerC2H2-type 4
HgeneZNF586chr19:58281246chr17:35413901ENST00000391702+14206_2280360.0Zinc fingerC2H2-type 5
HgeneZNF586chr19:58281246chr17:35413901ENST00000391702+14234_2560360.0Zinc fingerC2H2-type 6
HgeneZNF586chr19:58281246chr17:35413901ENST00000391702+14262_2840360.0Zinc fingerC2H2-type 7
HgeneZNF586chr19:58281246chr17:35413901ENST00000391702+14290_3120360.0Zinc fingerC2H2-type 8
HgeneZNF586chr19:58281246chr17:35413901ENST00000391702+14317_3390360.0Zinc fingerC2H2-type 9
HgeneZNF586chr19:58281246chr17:35413901ENST00000391702+14345_3670360.0Zinc fingerC2H2-type 10
HgeneZNF586chr19:58281246chr17:35413901ENST00000391702+14373_3950360.0Zinc fingerC2H2-type 11
HgeneZNF586chr19:58281246chr17:35413901ENST00000391702+1488_1160360.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF586chr19:58281246chr17:35413901ENST00000396150+12122_14412211.0Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF586chr19:58281246chr17:35413901ENST00000396150+12150_17212211.0Zinc fingerC2H2-type 3%3B degenerate
HgeneZNF586chr19:58281246chr17:35413901ENST00000396150+12178_20012211.0Zinc fingerC2H2-type 4
HgeneZNF586chr19:58281246chr17:35413901ENST00000396150+12206_22812211.0Zinc fingerC2H2-type 5
HgeneZNF586chr19:58281246chr17:35413901ENST00000396150+12234_25612211.0Zinc fingerC2H2-type 6
HgeneZNF586chr19:58281246chr17:35413901ENST00000396150+12262_28412211.0Zinc fingerC2H2-type 7
HgeneZNF586chr19:58281246chr17:35413901ENST00000396150+12290_31212211.0Zinc fingerC2H2-type 8
HgeneZNF586chr19:58281246chr17:35413901ENST00000396150+12317_33912211.0Zinc fingerC2H2-type 9
HgeneZNF586chr19:58281246chr17:35413901ENST00000396150+12345_36712211.0Zinc fingerC2H2-type 10
HgeneZNF586chr19:58281246chr17:35413901ENST00000396150+12373_39512211.0Zinc fingerC2H2-type 11
HgeneZNF586chr19:58281246chr17:35413901ENST00000396150+1288_11612211.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF586chr19:58281246chr17:35413901ENST00000396154+13122_14412403.0Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF586chr19:58281246chr17:35413901ENST00000396154+13150_17212403.0Zinc fingerC2H2-type 3%3B degenerate
HgeneZNF586chr19:58281246chr17:35413901ENST00000396154+13178_20012403.0Zinc fingerC2H2-type 4
HgeneZNF586chr19:58281246chr17:35413901ENST00000396154+13206_22812403.0Zinc fingerC2H2-type 5
HgeneZNF586chr19:58281246chr17:35413901ENST00000396154+13234_25612403.0Zinc fingerC2H2-type 6
HgeneZNF586chr19:58281246chr17:35413901ENST00000396154+13262_28412403.0Zinc fingerC2H2-type 7
HgeneZNF586chr19:58281246chr17:35413901ENST00000396154+13290_31212403.0Zinc fingerC2H2-type 8
HgeneZNF586chr19:58281246chr17:35413901ENST00000396154+13317_33912403.0Zinc fingerC2H2-type 9
HgeneZNF586chr19:58281246chr17:35413901ENST00000396154+13345_36712403.0Zinc fingerC2H2-type 10
HgeneZNF586chr19:58281246chr17:35413901ENST00000396154+13373_39512403.0Zinc fingerC2H2-type 11
HgeneZNF586chr19:58281246chr17:35413901ENST00000396154+1388_11612403.0Zinc fingerC2H2-type 1%3B degenerate
TgeneAATFchr19:58281246chr17:35413901ENST00000225402101296_195539561.0Compositional biasNote=Glu-rich
TgeneAATFchr19:58281246chr17:35413901ENST000002254021012273_315539561.0RegionNote=POLR2J binding
TgeneAATFchr19:58281246chr17:35413901ENST000002254021012316_372539561.0RegionNote=RB1 binding
TgeneAATFchr19:58281246chr17:35413901ENST000002254021012373_472539561.0RegionNote=RB1 and SP1 binding


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Fusion Gene Sequence for ZNF586-AATF


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>102455_102455_1_ZNF586-AATF_ZNF586_chr19_58281246_ENST00000396150_AATF_chr17_35413901_ENST00000225402_length(transcript)=454nt_BP=183nt
GATGCTGGGTCTGGACGAGCTCGGGAGGAGTGGTTGTGGCCATTGCACACAGGCGGATCTGAGGTTCGGCGACGCCGCTGGTCGCGACCC
GGGACAGGACAACGACAGGAACACCGCCGAGCCCGCGTTCCCCCCCCGCCCAGAGTCATGGCGGCAGCAGCCGCTCTGAGGGCGCCTGCT
CAGGACAGAACTGTACCGCTCTCTTTTTGGCCAGCTCCACCCTCCCGACGAAGGCCACGGGGATTGACATCGCCCACCTCCGACACCCAG
TGGGCGCCTTGGCTGGTGCGGCTGCTGGTCCAGATGGAGGAAACCAGTGACTTTATGGGGCTGAGCTAGTAGGGAAGCCCCTGGAAAGAT
GCTGCGTTCCGAACCTGTGCCTAATACACGCAAGGGCGCTGTCCCGCCCAACCCCGCCTTTAAACGCCACAAATAAAGAGCATTGTTACC

>102455_102455_1_ZNF586-AATF_ZNF586_chr19_58281246_ENST00000396150_AATF_chr17_35413901_ENST00000225402_length(amino acids)=144AA_BP=1
MWRLKAGLGGTAPLRVLGTGSERSIFPGASLLAQPHKVTGFLHLDQQPHQPRRPLGVGGGRCQSPWPSSGGWSWPKRERYSSVLSRRPQS

--------------------------------------------------------------
>102455_102455_2_ZNF586-AATF_ZNF586_chr19_58281246_ENST00000396154_AATF_chr17_35413901_ENST00000225402_length(transcript)=480nt_BP=209nt
ATTTTGGCCTGTCAGGTCCATCCGGCGATGCTGGGTCTGGACGAGCTCGGGAGGAGTGGTTGTGGCCATTGCACACAGGCGGATCTGAGG
TTCGGCGACGCCGCTGGTCGCGACCCGGGACAGGACAACGACAGGAACACCGCCGAGCCCGCGTTCCCCCCCCGCCCAGAGTCATGGCGG
CAGCAGCCGCTCTGAGGGCGCCTGCTCAGGACAGAACTGTACCGCTCTCTTTTTGGCCAGCTCCACCCTCCCGACGAAGGCCACGGGGAT
TGACATCGCCCACCTCCGACACCCAGTGGGCGCCTTGGCTGGTGCGGCTGCTGGTCCAGATGGAGGAAACCAGTGACTTTATGGGGCTGA
GCTAGTAGGGAAGCCCCTGGAAAGATGCTGCGTTCCGAACCTGTGCCTAATACACGCAAGGGCGCTGTCCCGCCCAACCCCGCCTTTAAA

>102455_102455_2_ZNF586-AATF_ZNF586_chr19_58281246_ENST00000396154_AATF_chr17_35413901_ENST00000225402_length(amino acids)=148AA_BP=1
MWRLKAGLGGTAPLRVLGTGSERSIFPGASLLAQPHKVTGFLHLDQQPHQPRRPLGVGGGRCQSPWPSSGGWSWPKRERYSSVLSRRPQS

--------------------------------------------------------------
>102455_102455_3_ZNF586-AATF_ZNF586_chr19_58281246_ENST00000598183_AATF_chr17_35413901_ENST00000225402_length(transcript)=483nt_BP=212nt
GCCATTTTGGCCTGTCAGGTCCATCCGGCGATGCTGGGTCTGGACGAGCTCGGGAGGAGTGGTTGTGGCCATTGCACACAGGCGGATCTG
AGGTTCGGCGACGCCGCTGGTCGCGACCCGGGACAGGACAACGACAGGAACACCGCCGAGCCCGCGTTCCCCCCCCGCCCAGAGTCATGG
CGGCAGCAGCCGCTCTGAGGGCGCCTGCTCAGGACAGAACTGTACCGCTCTCTTTTTGGCCAGCTCCACCCTCCCGACGAAGGCCACGGG
GATTGACATCGCCCACCTCCGACACCCAGTGGGCGCCTTGGCTGGTGCGGCTGCTGGTCCAGATGGAGGAAACCAGTGACTTTATGGGGC
TGAGCTAGTAGGGAAGCCCCTGGAAAGATGCTGCGTTCCGAACCTGTGCCTAATACACGCAAGGGCGCTGTCCCGCCCAACCCCGCCTTT

>102455_102455_3_ZNF586-AATF_ZNF586_chr19_58281246_ENST00000598183_AATF_chr17_35413901_ENST00000225402_length(amino acids)=148AA_BP=1
MWRLKAGLGGTAPLRVLGTGSERSIFPGASLLAQPHKVTGFLHLDQQPHQPRRPLGVGGGRCQSPWPSSGGWSWPKRERYSSVLSRRPQS

--------------------------------------------------------------
>102455_102455_4_ZNF586-AATF_ZNF586_chr19_58281246_ENST00000598885_AATF_chr17_35413901_ENST00000225402_length(transcript)=489nt_BP=218nt
GTGGCAGCCATTTTGGCCTGTCAGGTCCATCCGGCGATGCTGGGTCTGGACGAGCTCGGGAGGAGTGGTTGTGGCCATTGCACACAGGCG
GATCTGAGGTTCGGCGACGCCGCTGGTCGCGACCCGGGACAGGACAACGACAGGAACACCGCCGAGCCCGCGTTCCCCCCCCGCCCAGAG
TCATGGCGGCAGCAGCCGCTCTGAGGGCGCCTGCTCAGGACAGAACTGTACCGCTCTCTTTTTGGCCAGCTCCACCCTCCCGACGAAGGC
CACGGGGATTGACATCGCCCACCTCCGACACCCAGTGGGCGCCTTGGCTGGTGCGGCTGCTGGTCCAGATGGAGGAAACCAGTGACTTTA
TGGGGCTGAGCTAGTAGGGAAGCCCCTGGAAAGATGCTGCGTTCCGAACCTGTGCCTAATACACGCAAGGGCGCTGTCCCGCCCAACCCC

>102455_102455_4_ZNF586-AATF_ZNF586_chr19_58281246_ENST00000598885_AATF_chr17_35413901_ENST00000225402_length(amino acids)=148AA_BP=1
MWRLKAGLGGTAPLRVLGTGSERSIFPGASLLAQPHKVTGFLHLDQQPHQPRRPLGVGGGRCQSPWPSSGGWSWPKRERYSSVLSRRPQS

--------------------------------------------------------------
>102455_102455_5_ZNF586-AATF_ZNF586_chr19_58281246_ENST00000599802_AATF_chr17_35413901_ENST00000225402_length(transcript)=480nt_BP=209nt
ATTTTGGCCTGTCAGGTCCATCCGGCGATGCTGGGTCTGGACGAGCTCGGGAGGAGTGGTTGTGGCCATTGCACACAGGCGGATCTGAGG
TTCGGCGACGCCGCTGGTCGCGACCCGGGACAGGACAACGACAGGAACACCGCCGAGCCCGCGTTCCCCCCCCGCCCAGAGTCATGGCGG
CAGCAGCCGCTCTGAGGGCGCCTGCTCAGGACAGAACTGTACCGCTCTCTTTTTGGCCAGCTCCACCCTCCCGACGAAGGCCACGGGGAT
TGACATCGCCCACCTCCGACACCCAGTGGGCGCCTTGGCTGGTGCGGCTGCTGGTCCAGATGGAGGAAACCAGTGACTTTATGGGGCTGA
GCTAGTAGGGAAGCCCCTGGAAAGATGCTGCGTTCCGAACCTGTGCCTAATACACGCAAGGGCGCTGTCCCGCCCAACCCCGCCTTTAAA

>102455_102455_5_ZNF586-AATF_ZNF586_chr19_58281246_ENST00000599802_AATF_chr17_35413901_ENST00000225402_length(amino acids)=148AA_BP=1
MWRLKAGLGGTAPLRVLGTGSERSIFPGASLLAQPHKVTGFLHLDQQPHQPRRPLGVGGGRCQSPWPSSGGWSWPKRERYSSVLSRRPQS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZNF586-AATF


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF586-AATF


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF586-AATF


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource