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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF586-AURKC (FusionGDB2 ID:102456)

Fusion Gene Summary for ZNF586-AURKC

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF586-AURKC
Fusion gene ID: 102456
HgeneTgene
Gene symbol

ZNF586

AURKC

Gene ID

54807

6795

Gene namezinc finger protein 586aurora kinase C
Synonyms-AIE2|AIK3|ARK3|AurC|HEL-S-90|SPGF5|STK13|aurora-C
Cytomap

19q13.43

19q13.43

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 586aurora kinase CARK-3aurora 3aurora-related kinase 3aurora/IPL1-related kinase 3aurora/IPL1/EG2 protein 2epididymis secretory protein Li 90serine/threonine kinase 13 (aurora/IPL1-like)serine/threonine-protein kinase 13serine/threonine-protein kina
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000598183, ENST00000598885, 
ENST00000391702, ENST00000396150, 
ENST00000396154, ENST00000599802, 
ENST00000302804, ENST00000448930, 
ENST00000598785, ENST00000599062, 
ENST00000415300, 
Fusion gene scores* DoF score6 X 5 X 5=1505 X 4 X 3=60
# samples 75
** MAII scorelog2(7/150*10)=-1.09953567355091
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF586 [Title/Abstract] AND AURKC [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF586(58301768)-AURKC(57743110), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneAURKC

GO:0006468

protein phosphorylation

15670791


check buttonFusion gene breakpoints across ZNF586 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AURKC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-PG-A914ZNF586chr19

58301768

+AURKCchr19

57743110

+


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Fusion Gene ORF analysis for ZNF586-AURKC

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000598183ENST00000302804ZNF586chr19

58301768

+AURKCchr19

57743110

+
5CDS-5UTRENST00000598183ENST00000448930ZNF586chr19

58301768

+AURKCchr19

57743110

+
5CDS-5UTRENST00000598183ENST00000598785ZNF586chr19

58301768

+AURKCchr19

57743110

+
5CDS-5UTRENST00000598885ENST00000302804ZNF586chr19

58301768

+AURKCchr19

57743110

+
5CDS-5UTRENST00000598885ENST00000448930ZNF586chr19

58301768

+AURKCchr19

57743110

+
5CDS-5UTRENST00000598885ENST00000598785ZNF586chr19

58301768

+AURKCchr19

57743110

+
5CDS-intronENST00000598183ENST00000599062ZNF586chr19

58301768

+AURKCchr19

57743110

+
5CDS-intronENST00000598885ENST00000599062ZNF586chr19

58301768

+AURKCchr19

57743110

+
In-frameENST00000598183ENST00000415300ZNF586chr19

58301768

+AURKCchr19

57743110

+
In-frameENST00000598885ENST00000415300ZNF586chr19

58301768

+AURKCchr19

57743110

+
intron-3CDSENST00000391702ENST00000415300ZNF586chr19

58301768

+AURKCchr19

57743110

+
intron-3CDSENST00000396150ENST00000415300ZNF586chr19

58301768

+AURKCchr19

57743110

+
intron-3CDSENST00000396154ENST00000415300ZNF586chr19

58301768

+AURKCchr19

57743110

+
intron-3CDSENST00000599802ENST00000415300ZNF586chr19

58301768

+AURKCchr19

57743110

+
intron-5UTRENST00000391702ENST00000302804ZNF586chr19

58301768

+AURKCchr19

57743110

+
intron-5UTRENST00000391702ENST00000448930ZNF586chr19

58301768

+AURKCchr19

57743110

+
intron-5UTRENST00000391702ENST00000598785ZNF586chr19

58301768

+AURKCchr19

57743110

+
intron-5UTRENST00000396150ENST00000302804ZNF586chr19

58301768

+AURKCchr19

57743110

+
intron-5UTRENST00000396150ENST00000448930ZNF586chr19

58301768

+AURKCchr19

57743110

+
intron-5UTRENST00000396150ENST00000598785ZNF586chr19

58301768

+AURKCchr19

57743110

+
intron-5UTRENST00000396154ENST00000302804ZNF586chr19

58301768

+AURKCchr19

57743110

+
intron-5UTRENST00000396154ENST00000448930ZNF586chr19

58301768

+AURKCchr19

57743110

+
intron-5UTRENST00000396154ENST00000598785ZNF586chr19

58301768

+AURKCchr19

57743110

+
intron-5UTRENST00000599802ENST00000302804ZNF586chr19

58301768

+AURKCchr19

57743110

+
intron-5UTRENST00000599802ENST00000448930ZNF586chr19

58301768

+AURKCchr19

57743110

+
intron-5UTRENST00000599802ENST00000598785ZNF586chr19

58301768

+AURKCchr19

57743110

+
intron-intronENST00000391702ENST00000599062ZNF586chr19

58301768

+AURKCchr19

57743110

+
intron-intronENST00000396150ENST00000599062ZNF586chr19

58301768

+AURKCchr19

57743110

+
intron-intronENST00000396154ENST00000599062ZNF586chr19

58301768

+AURKCchr19

57743110

+
intron-intronENST00000599802ENST00000599062ZNF586chr19

58301768

+AURKCchr19

57743110

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000598885ZNF586chr1958301768+ENST00000415300AURKCchr1957743110+1217345171216400
ENST00000598183ZNF586chr1958301768+ENST00000415300AURKCchr1957743110+1211339111210400

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000598885ENST00000415300ZNF586chr1958301768+AURKCchr1957743110+0.0036994660.99630046
ENST00000598183ENST00000415300ZNF586chr1958301768+AURKCchr1957743110+0.0035289490.99647105

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Fusion Genomic Features for ZNF586-AURKC


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ZNF586chr1958301768+AURKCchr1957743109+5.93E-070.9999994
ZNF586chr1958301768+AURKCchr1957743109+5.93E-070.9999994

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ZNF586-AURKC


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:58301768/chr19:57743110)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAURKCchr19:58301768chr19:57743110ENST000003028040743_29319310.0DomainProtein kinase
TgeneAURKCchr19:58301768chr19:57743110ENST000004153000743_2930291.0DomainProtein kinase
TgeneAURKCchr19:58301768chr19:57743110ENST000004489300743_2930276.0DomainProtein kinase
TgeneAURKCchr19:58301768chr19:57743110ENST000005987850643_2930276.0DomainProtein kinase
TgeneAURKCchr19:58301768chr19:57743110ENST000003028040749_5719310.0Nucleotide bindingATP
TgeneAURKCchr19:58301768chr19:57743110ENST000004153000749_570291.0Nucleotide bindingATP
TgeneAURKCchr19:58301768chr19:57743110ENST000004489300749_570276.0Nucleotide bindingATP
TgeneAURKCchr19:58301768chr19:57743110ENST000005987850649_570276.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF586chr19:58301768chr19:57743110ENST00000391702+1415_870360.0DomainKRAB
HgeneZNF586chr19:58301768chr19:57743110ENST00000396150+1215_870211.0DomainKRAB
HgeneZNF586chr19:58301768chr19:57743110ENST00000396154+1315_870403.0DomainKRAB
HgeneZNF586chr19:58301768chr19:57743110ENST00000391702+14122_1440360.0Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF586chr19:58301768chr19:57743110ENST00000391702+14150_1720360.0Zinc fingerC2H2-type 3%3B degenerate
HgeneZNF586chr19:58301768chr19:57743110ENST00000391702+14178_2000360.0Zinc fingerC2H2-type 4
HgeneZNF586chr19:58301768chr19:57743110ENST00000391702+14206_2280360.0Zinc fingerC2H2-type 5
HgeneZNF586chr19:58301768chr19:57743110ENST00000391702+14234_2560360.0Zinc fingerC2H2-type 6
HgeneZNF586chr19:58301768chr19:57743110ENST00000391702+14262_2840360.0Zinc fingerC2H2-type 7
HgeneZNF586chr19:58301768chr19:57743110ENST00000391702+14290_3120360.0Zinc fingerC2H2-type 8
HgeneZNF586chr19:58301768chr19:57743110ENST00000391702+14317_3390360.0Zinc fingerC2H2-type 9
HgeneZNF586chr19:58301768chr19:57743110ENST00000391702+14345_3670360.0Zinc fingerC2H2-type 10
HgeneZNF586chr19:58301768chr19:57743110ENST00000391702+14373_3950360.0Zinc fingerC2H2-type 11
HgeneZNF586chr19:58301768chr19:57743110ENST00000391702+1488_1160360.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF586chr19:58301768chr19:57743110ENST00000396150+12122_1440211.0Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF586chr19:58301768chr19:57743110ENST00000396150+12150_1720211.0Zinc fingerC2H2-type 3%3B degenerate
HgeneZNF586chr19:58301768chr19:57743110ENST00000396150+12178_2000211.0Zinc fingerC2H2-type 4
HgeneZNF586chr19:58301768chr19:57743110ENST00000396150+12206_2280211.0Zinc fingerC2H2-type 5
HgeneZNF586chr19:58301768chr19:57743110ENST00000396150+12234_2560211.0Zinc fingerC2H2-type 6
HgeneZNF586chr19:58301768chr19:57743110ENST00000396150+12262_2840211.0Zinc fingerC2H2-type 7
HgeneZNF586chr19:58301768chr19:57743110ENST00000396150+12290_3120211.0Zinc fingerC2H2-type 8
HgeneZNF586chr19:58301768chr19:57743110ENST00000396150+12317_3390211.0Zinc fingerC2H2-type 9
HgeneZNF586chr19:58301768chr19:57743110ENST00000396150+12345_3670211.0Zinc fingerC2H2-type 10
HgeneZNF586chr19:58301768chr19:57743110ENST00000396150+12373_3950211.0Zinc fingerC2H2-type 11
HgeneZNF586chr19:58301768chr19:57743110ENST00000396150+1288_1160211.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF586chr19:58301768chr19:57743110ENST00000396154+13122_1440403.0Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF586chr19:58301768chr19:57743110ENST00000396154+13150_1720403.0Zinc fingerC2H2-type 3%3B degenerate
HgeneZNF586chr19:58301768chr19:57743110ENST00000396154+13178_2000403.0Zinc fingerC2H2-type 4
HgeneZNF586chr19:58301768chr19:57743110ENST00000396154+13206_2280403.0Zinc fingerC2H2-type 5
HgeneZNF586chr19:58301768chr19:57743110ENST00000396154+13234_2560403.0Zinc fingerC2H2-type 6
HgeneZNF586chr19:58301768chr19:57743110ENST00000396154+13262_2840403.0Zinc fingerC2H2-type 7
HgeneZNF586chr19:58301768chr19:57743110ENST00000396154+13290_3120403.0Zinc fingerC2H2-type 8
HgeneZNF586chr19:58301768chr19:57743110ENST00000396154+13317_3390403.0Zinc fingerC2H2-type 9
HgeneZNF586chr19:58301768chr19:57743110ENST00000396154+13345_3670403.0Zinc fingerC2H2-type 10
HgeneZNF586chr19:58301768chr19:57743110ENST00000396154+13373_3950403.0Zinc fingerC2H2-type 11
HgeneZNF586chr19:58301768chr19:57743110ENST00000396154+1388_1160403.0Zinc fingerC2H2-type 1%3B degenerate


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Fusion Gene Sequence for ZNF586-AURKC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>102456_102456_1_ZNF586-AURKC_ZNF586_chr19_58301768_ENST00000598183_AURKC_chr19_57743110_ENST00000415300_length(transcript)=1211nt_BP=339nt
GCCATTTTGGCCTGTCAGGTCCATCCGGCGATGCTGGGTCTGGACGAGCTCGGGAGGAGTGGTTGTGGCCATTGCACACAGGCGGATCTG
AGGTTCGGCGACGCCGCTGGTCGCGACCCGGGACAGGACAACGACAGGAACACCGCCGAGCCCGCGTTCCCCCCCCGCCCAGAGTCATGG
CGGCAGCAGCCGCTCTGAGGGCGCCTGCTCAGAGCAGTGTGACCTTTGAAGACGTGGCTGTAAACTTTTCCCTGGAGGAATGGAGTCTTC
TTAATGAGGCTCAGGGATGCCTGTACCATGATGTGATGCTGGAGACCTTGACACTTATATCCTCCCTGGTGGCTACAGCAAACCAAACAG
CCCAGCAGCCCAGCAGCCCAGCCATGCGGCGCCTCACAGTCGATGACTTTGAAATCGGGCGTCCCCTGGGCAAGGGGAAATTTGGGAATG
TGTACCTGGCTCGGCTCAAGGAAAGCCATTTCATTGTGGCCCTGAAGGTTCTCTTCAAGTCGCAGATAGAGAAGGAAGGACTGGAGCACC
AGCTGCGCCGGGAAATTGAGATCCAGGCTCATCTACAACACCCCAATATCCTGCGCCTGTATAACTATTTCCATGATGCACGCCGGGTGT
ACCTGATTCTGGAATATGCTCCAAGGGGTGAGCTCTACAAGGAGCTGCAGAAAAGCGAGAAATTAGATGAACAGCGCACAGCCACGATAA
TAGAGGAGTTGGCAGATGCCCTGACCTACTGCCATGACAAGAAAGTGATTCACAGAGATATTAAGCCAGAGAACCTGCTGCTGGGGTTCA
GGGGTGAGGTGAAGATTGCAGATTTTGGCTGGTCTGTGCACACCCCCTCCCTGAGGAGGAAGACAATGTGTGGGACACTGGACTACTTGC
CGCCAGAAATGATTGAGGGGAGAACATATGATGAAAAGGTGGATTTGTGGTGCATTGGAGTGCTCTGCTATGAGCTGCTGGTGGGATATC
CACCCTTTGAGAGCGCCTCCCACAGTGAGACTTACAGACGCATCCTCAAGGTAGATGTGAGGTTTCCACTATCAATGCCTCTGGGGGCCC
GGGACTTGATTTCCAGGCTTCTCAGATACCAGCCCTTGGAGAGACTGCCCCTGGCCCAGATCCTGAAGCACCCCTGGGTTCAGGCCCACT

>102456_102456_1_ZNF586-AURKC_ZNF586_chr19_58301768_ENST00000598183_AURKC_chr19_57743110_ENST00000415300_length(amino acids)=400AA_BP=66
MSGPSGDAGSGRAREEWLWPLHTGGSEVRRRRWSRPGTGQRQEHRRARVPPPPRVMAAAAALRAPAQSSVTFEDVAVNFSLEEWSLLNEA
QGCLYHDVMLETLTLISSLVATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRR
EIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEV
KIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLI

--------------------------------------------------------------
>102456_102456_2_ZNF586-AURKC_ZNF586_chr19_58301768_ENST00000598885_AURKC_chr19_57743110_ENST00000415300_length(transcript)=1217nt_BP=345nt
GTGGCAGCCATTTTGGCCTGTCAGGTCCATCCGGCGATGCTGGGTCTGGACGAGCTCGGGAGGAGTGGTTGTGGCCATTGCACACAGGCG
GATCTGAGGTTCGGCGACGCCGCTGGTCGCGACCCGGGACAGGACAACGACAGGAACACCGCCGAGCCCGCGTTCCCCCCCCGCCCAGAG
TCATGGCGGCAGCAGCCGCTCTGAGGGCGCCTGCTCAGAGCAGTGTGACCTTTGAAGACGTGGCTGTAAACTTTTCCCTGGAGGAATGGA
GTCTTCTTAATGAGGCTCAGGGATGCCTGTACCATGATGTGATGCTGGAGACCTTGACACTTATATCCTCCCTGGTGGCTACAGCAAACC
AAACAGCCCAGCAGCCCAGCAGCCCAGCCATGCGGCGCCTCACAGTCGATGACTTTGAAATCGGGCGTCCCCTGGGCAAGGGGAAATTTG
GGAATGTGTACCTGGCTCGGCTCAAGGAAAGCCATTTCATTGTGGCCCTGAAGGTTCTCTTCAAGTCGCAGATAGAGAAGGAAGGACTGG
AGCACCAGCTGCGCCGGGAAATTGAGATCCAGGCTCATCTACAACACCCCAATATCCTGCGCCTGTATAACTATTTCCATGATGCACGCC
GGGTGTACCTGATTCTGGAATATGCTCCAAGGGGTGAGCTCTACAAGGAGCTGCAGAAAAGCGAGAAATTAGATGAACAGCGCACAGCCA
CGATAATAGAGGAGTTGGCAGATGCCCTGACCTACTGCCATGACAAGAAAGTGATTCACAGAGATATTAAGCCAGAGAACCTGCTGCTGG
GGTTCAGGGGTGAGGTGAAGATTGCAGATTTTGGCTGGTCTGTGCACACCCCCTCCCTGAGGAGGAAGACAATGTGTGGGACACTGGACT
ACTTGCCGCCAGAAATGATTGAGGGGAGAACATATGATGAAAAGGTGGATTTGTGGTGCATTGGAGTGCTCTGCTATGAGCTGCTGGTGG
GATATCCACCCTTTGAGAGCGCCTCCCACAGTGAGACTTACAGACGCATCCTCAAGGTAGATGTGAGGTTTCCACTATCAATGCCTCTGG
GGGCCCGGGACTTGATTTCCAGGCTTCTCAGATACCAGCCCTTGGAGAGACTGCCCCTGGCCCAGATCCTGAAGCACCCCTGGGTTCAGG

>102456_102456_2_ZNF586-AURKC_ZNF586_chr19_58301768_ENST00000598885_AURKC_chr19_57743110_ENST00000415300_length(amino acids)=400AA_BP=66
MSGPSGDAGSGRAREEWLWPLHTGGSEVRRRRWSRPGTGQRQEHRRARVPPPPRVMAAAAALRAPAQSSVTFEDVAVNFSLEEWSLLNEA
QGCLYHDVMLETLTLISSLVATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRR
EIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEV
KIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZNF586-AURKC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneAURKCchr19:58301768chr19:57743110ENST0000030280407292_30919.333333333333332310.0BIRC5
TgeneAURKCchr19:58301768chr19:57743110ENST0000041530007292_3090.3333333333333333291.0BIRC5
TgeneAURKCchr19:58301768chr19:57743110ENST0000044893007292_3090276.0BIRC5
TgeneAURKCchr19:58301768chr19:57743110ENST0000059878506292_3090276.0BIRC5


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF586-AURKC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF586-AURKC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource