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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF586-EIF4A1 (FusionGDB2 ID:102457)

Fusion Gene Summary for ZNF586-EIF4A1

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF586-EIF4A1
Fusion gene ID: 102457
HgeneTgene
Gene symbol

ZNF586

EIF4A1

Gene ID

54807

1973

Gene namezinc finger protein 586eukaryotic translation initiation factor 4A1
Synonyms-DDX2A|EIF-4A|EIF4A|eIF-4A-I|eIF4A-I
Cytomap

19q13.43

17p13.1

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 586eukaryotic initiation factor 4A-IATP-dependent RNA helicase eIF4A-1eukaryotic initiation factor 4AIeukaryotic translation initiation factor 4A
Modification date2020031320200322
UniProtAcc.

P60842

Ensembl transtripts involved in fusion geneENST00000391702, ENST00000396154, 
ENST00000396150, ENST00000598183, 
ENST00000598885, ENST00000599802, 
ENST00000581808, ENST00000380512, 
ENST00000293831, ENST00000577269, 
ENST00000582746, 
Fusion gene scores* DoF score6 X 5 X 5=1508 X 5 X 5=200
# samples 78
** MAII scorelog2(7/150*10)=-1.09953567355091
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/200*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF586 [Title/Abstract] AND EIF4A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF586(58288037)-EIF4A1(7478436), # samples:1
Anticipated loss of major functional domain due to fusion event.ZNF586-EIF4A1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ZNF586-EIF4A1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ZNF586-EIF4A1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ZNF586 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EIF4A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-29-1766ZNF586chr19

58288037

+EIF4A1chr17

7478436

+


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Fusion Gene ORF analysis for ZNF586-EIF4A1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000391702ENST00000581808ZNF586chr19

58288037

+EIF4A1chr17

7478436

+
5CDS-intronENST00000396154ENST00000581808ZNF586chr19

58288037

+EIF4A1chr17

7478436

+
Frame-shiftENST00000391702ENST00000380512ZNF586chr19

58288037

+EIF4A1chr17

7478436

+
Frame-shiftENST00000396154ENST00000380512ZNF586chr19

58288037

+EIF4A1chr17

7478436

+
In-frameENST00000391702ENST00000293831ZNF586chr19

58288037

+EIF4A1chr17

7478436

+
In-frameENST00000391702ENST00000577269ZNF586chr19

58288037

+EIF4A1chr17

7478436

+
In-frameENST00000391702ENST00000582746ZNF586chr19

58288037

+EIF4A1chr17

7478436

+
In-frameENST00000396154ENST00000293831ZNF586chr19

58288037

+EIF4A1chr17

7478436

+
In-frameENST00000396154ENST00000577269ZNF586chr19

58288037

+EIF4A1chr17

7478436

+
In-frameENST00000396154ENST00000582746ZNF586chr19

58288037

+EIF4A1chr17

7478436

+
intron-3CDSENST00000396150ENST00000293831ZNF586chr19

58288037

+EIF4A1chr17

7478436

+
intron-3CDSENST00000396150ENST00000380512ZNF586chr19

58288037

+EIF4A1chr17

7478436

+
intron-3CDSENST00000396150ENST00000577269ZNF586chr19

58288037

+EIF4A1chr17

7478436

+
intron-3CDSENST00000396150ENST00000582746ZNF586chr19

58288037

+EIF4A1chr17

7478436

+
intron-3CDSENST00000598183ENST00000293831ZNF586chr19

58288037

+EIF4A1chr17

7478436

+
intron-3CDSENST00000598183ENST00000380512ZNF586chr19

58288037

+EIF4A1chr17

7478436

+
intron-3CDSENST00000598183ENST00000577269ZNF586chr19

58288037

+EIF4A1chr17

7478436

+
intron-3CDSENST00000598183ENST00000582746ZNF586chr19

58288037

+EIF4A1chr17

7478436

+
intron-3CDSENST00000598885ENST00000293831ZNF586chr19

58288037

+EIF4A1chr17

7478436

+
intron-3CDSENST00000598885ENST00000380512ZNF586chr19

58288037

+EIF4A1chr17

7478436

+
intron-3CDSENST00000598885ENST00000577269ZNF586chr19

58288037

+EIF4A1chr17

7478436

+
intron-3CDSENST00000598885ENST00000582746ZNF586chr19

58288037

+EIF4A1chr17

7478436

+
intron-3CDSENST00000599802ENST00000293831ZNF586chr19

58288037

+EIF4A1chr17

7478436

+
intron-3CDSENST00000599802ENST00000380512ZNF586chr19

58288037

+EIF4A1chr17

7478436

+
intron-3CDSENST00000599802ENST00000577269ZNF586chr19

58288037

+EIF4A1chr17

7478436

+
intron-3CDSENST00000599802ENST00000582746ZNF586chr19

58288037

+EIF4A1chr17

7478436

+
intron-intronENST00000396150ENST00000581808ZNF586chr19

58288037

+EIF4A1chr17

7478436

+
intron-intronENST00000598183ENST00000581808ZNF586chr19

58288037

+EIF4A1chr17

7478436

+
intron-intronENST00000598885ENST00000581808ZNF586chr19

58288037

+EIF4A1chr17

7478436

+
intron-intronENST00000599802ENST00000581808ZNF586chr19

58288037

+EIF4A1chr17

7478436

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000391702ZNF586chr1958288037+ENST00000293831EIF4A1chr177478436+19364013131416367
ENST00000391702ZNF586chr1958288037+ENST00000577269EIF4A1chr177478436+15104013131239308
ENST00000391702ZNF586chr1958288037+ENST00000582746EIF4A1chr177478436+18414013131221302
ENST00000396154ZNF586chr1958288037+ENST00000293831EIF4A1chr177478436+187133681351447
ENST00000396154ZNF586chr1958288037+ENST00000577269EIF4A1chr177478436+144533681174388
ENST00000396154ZNF586chr1958288037+ENST00000582746EIF4A1chr177478436+177633681156382

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000391702ENST00000293831ZNF586chr1958288037+EIF4A1chr177478436+0.0016750080.99832493
ENST00000391702ENST00000577269ZNF586chr1958288037+EIF4A1chr177478436+0.0028536560.9971463
ENST00000391702ENST00000582746ZNF586chr1958288037+EIF4A1chr177478436+0.0028326940.9971673
ENST00000396154ENST00000293831ZNF586chr1958288037+EIF4A1chr177478436+0.0008619780.999138
ENST00000396154ENST00000577269ZNF586chr1958288037+EIF4A1chr177478436+0.0013577950.99864227
ENST00000396154ENST00000582746ZNF586chr1958288037+EIF4A1chr177478436+0.0011667460.99883324

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Fusion Genomic Features for ZNF586-EIF4A1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ZNF586chr1958288037+EIF4A1chr177478436+0.0007027210.99929726
ZNF586chr1958288037+EIF4A1chr177478436+0.0007027210.99929726

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ZNF586-EIF4A1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:58288037/chr17:7478436)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.EIF4A1

P60842

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. {ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneEIF4A1chr19:58288037chr17:7478436ENST00000293831211245_40668407.0DomainHelicase C-terminal
TgeneEIF4A1chr19:58288037chr17:7478436ENST00000577269211245_40668348.0DomainHelicase C-terminal
TgeneEIF4A1chr19:58288037chr17:7478436ENST00000293831211182_18568407.0MotifNote=DEAD box
TgeneEIF4A1chr19:58288037chr17:7478436ENST00000577269211182_18568348.0MotifNote=DEAD box
TgeneEIF4A1chr19:58288037chr17:7478436ENST0000029383121176_8368407.0Nucleotide bindingATP
TgeneEIF4A1chr19:58288037chr17:7478436ENST0000057726921176_8368348.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF586chr19:58288037chr17:7478436ENST00000391702+3415_8711360.0DomainKRAB
HgeneZNF586chr19:58288037chr17:7478436ENST00000396150+1215_870211.0DomainKRAB
HgeneZNF586chr19:58288037chr17:7478436ENST00000396154+2315_8754403.0DomainKRAB
HgeneZNF586chr19:58288037chr17:7478436ENST00000391702+34122_14411360.0Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF586chr19:58288037chr17:7478436ENST00000391702+34150_17211360.0Zinc fingerC2H2-type 3%3B degenerate
HgeneZNF586chr19:58288037chr17:7478436ENST00000391702+34178_20011360.0Zinc fingerC2H2-type 4
HgeneZNF586chr19:58288037chr17:7478436ENST00000391702+34206_22811360.0Zinc fingerC2H2-type 5
HgeneZNF586chr19:58288037chr17:7478436ENST00000391702+34234_25611360.0Zinc fingerC2H2-type 6
HgeneZNF586chr19:58288037chr17:7478436ENST00000391702+34262_28411360.0Zinc fingerC2H2-type 7
HgeneZNF586chr19:58288037chr17:7478436ENST00000391702+34290_31211360.0Zinc fingerC2H2-type 8
HgeneZNF586chr19:58288037chr17:7478436ENST00000391702+34317_33911360.0Zinc fingerC2H2-type 9
HgeneZNF586chr19:58288037chr17:7478436ENST00000391702+34345_36711360.0Zinc fingerC2H2-type 10
HgeneZNF586chr19:58288037chr17:7478436ENST00000391702+34373_39511360.0Zinc fingerC2H2-type 11
HgeneZNF586chr19:58288037chr17:7478436ENST00000391702+3488_11611360.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF586chr19:58288037chr17:7478436ENST00000396150+12122_1440211.0Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF586chr19:58288037chr17:7478436ENST00000396150+12150_1720211.0Zinc fingerC2H2-type 3%3B degenerate
HgeneZNF586chr19:58288037chr17:7478436ENST00000396150+12178_2000211.0Zinc fingerC2H2-type 4
HgeneZNF586chr19:58288037chr17:7478436ENST00000396150+12206_2280211.0Zinc fingerC2H2-type 5
HgeneZNF586chr19:58288037chr17:7478436ENST00000396150+12234_2560211.0Zinc fingerC2H2-type 6
HgeneZNF586chr19:58288037chr17:7478436ENST00000396150+12262_2840211.0Zinc fingerC2H2-type 7
HgeneZNF586chr19:58288037chr17:7478436ENST00000396150+12290_3120211.0Zinc fingerC2H2-type 8
HgeneZNF586chr19:58288037chr17:7478436ENST00000396150+12317_3390211.0Zinc fingerC2H2-type 9
HgeneZNF586chr19:58288037chr17:7478436ENST00000396150+12345_3670211.0Zinc fingerC2H2-type 10
HgeneZNF586chr19:58288037chr17:7478436ENST00000396150+12373_3950211.0Zinc fingerC2H2-type 11
HgeneZNF586chr19:58288037chr17:7478436ENST00000396150+1288_1160211.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF586chr19:58288037chr17:7478436ENST00000396154+23122_14454403.0Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF586chr19:58288037chr17:7478436ENST00000396154+23150_17254403.0Zinc fingerC2H2-type 3%3B degenerate
HgeneZNF586chr19:58288037chr17:7478436ENST00000396154+23178_20054403.0Zinc fingerC2H2-type 4
HgeneZNF586chr19:58288037chr17:7478436ENST00000396154+23206_22854403.0Zinc fingerC2H2-type 5
HgeneZNF586chr19:58288037chr17:7478436ENST00000396154+23234_25654403.0Zinc fingerC2H2-type 6
HgeneZNF586chr19:58288037chr17:7478436ENST00000396154+23262_28454403.0Zinc fingerC2H2-type 7
HgeneZNF586chr19:58288037chr17:7478436ENST00000396154+23290_31254403.0Zinc fingerC2H2-type 8
HgeneZNF586chr19:58288037chr17:7478436ENST00000396154+23317_33954403.0Zinc fingerC2H2-type 9
HgeneZNF586chr19:58288037chr17:7478436ENST00000396154+23345_36754403.0Zinc fingerC2H2-type 10
HgeneZNF586chr19:58288037chr17:7478436ENST00000396154+23373_39554403.0Zinc fingerC2H2-type 11
HgeneZNF586chr19:58288037chr17:7478436ENST00000396154+2388_11654403.0Zinc fingerC2H2-type 1%3B degenerate
TgeneEIF4A1chr19:58288037chr17:7478436ENST0000029383121163_23468407.0DomainHelicase ATP-binding
TgeneEIF4A1chr19:58288037chr17:7478436ENST0000057726921163_23468348.0DomainHelicase ATP-binding
TgeneEIF4A1chr19:58288037chr17:7478436ENST0000029383121132_6068407.0MotifNote=Q motif
TgeneEIF4A1chr19:58288037chr17:7478436ENST0000057726921132_6068348.0MotifNote=Q motif


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Fusion Gene Sequence for ZNF586-EIF4A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>102457_102457_1_ZNF586-EIF4A1_ZNF586_chr19_58288037_ENST00000391702_EIF4A1_chr17_7478436_ENST00000293831_length(transcript)=1936nt_BP=401nt
CTAGCCGTGGCAGCCATTTTGGCCTGTCAGGTCCATCCGGCGATGCTGGGTCTGGACGAGCTCGGGAGGAGTGGTTGTGGCCATTGCACA
CAGGCGGATCTGAGGTTCGGCGACGCCGCTGGTCGCGACCCGGGACAGGACAACGACAGGAACACCGCCGAGCCCGCGTTCCCCCCCCGC
CCAGAGTCATGGCGGCAGCAGCCGCTCTGAGGGCGCCTGCTCAGACTACTGTGGATGATGTCAGCCACATTATGGTGTAAGCCCTAAAGT
TAAGAGCAGTGTGACCTTTGAAGATGTGGCTGTAAACTTTTCCCTGGAGGAATGGAGTCTTCTTAATGAGGCTCAGAGATGCCTGTACCG
TGACGTGATGCTGGAGACCTTGACACTTATATCCTCCCTGGGTTATGATGTGATTGCTCAAGCCCAATCTGGGACTGGGAAAACGGCCAC
ATTTGCCATATCGATTCTGCAGCAGATTGAATTAGATCTAAAAGCCACCCAGGCCTTGGTCCTAGCACCCACTCGAGAATTGGCTCAGCA
GATACAGAAGGTGGTCATGGCACTAGGAGACTACATGGGCGCCTCCTGTCACGCCTGTATCGGGGGCACCAACGTGCGTGCTGAGGTGCA
GAAACTGCAGATGGAAGCTCCCCACATCATCGTGGGTACCCCTGGCCGTGTGTTTGATATGCTTAACCGGAGATACCTGTCCCCCAAATA
CATCAAGATGTTTGTACTGGATGAAGCTGACGAAATGTTAAGCCGTGGATTCAAGGACCAGATCTATGACATATTCCAAAAGCTCAACAG
CAACACCCAGGTAGTTTTGCTGTCAGCCACAATGCCTTCTGATGTGCTTGAGGTGACCAAGAAGTTCATGAGGGACCCCATTCGGATTCT
TGTCAAGAAGGAAGAGTTGACCCTGGAGGGTATCCGCCAGTTCTACATCAACGTGGAACGAGAGGAGTGGAAGCTGGACACACTATGTGA
CTTGTATGAAACCCTGACCATCACCCAGGCAGTCATCTTCATCAACACCCGGAGGAAGGTGGACTGGCTCACCGAGAAGATGCATGCTCG
AGATTTCACTGTATCCGCCATGCATGGAGATATGGACCAAAAGGAACGAGACGTGATTATGAGGGAGTTTCGTTCTGGCTCTAGCAGAGT
TTTGATTACCACTGACCTGCTGGCCAGAGGCATTGATGTGCAGCAGGTTTCTTTAGTCATCAACTATGACCTTCCCACCAACAGGGAAAA
CTATATCCACAGAATCGGTCGAGGTGGACGGTTTGGCCGTAAAGGTGTGGCTATTAACATGGTGACAGAAGAAGACAAGAGGACTCTTCG
AGACATTGAGACCTTCTACAACACCTCCATTGAGGAAATGCCCCTCAATGTTGCTGACCTCATCTGAGGGGCTGTCCTGCCACCCAGCCC
CAGCCAGGGCTCAATCTCTGGGGGCTGAGGAGCAGCAGGAGGGGGGAGGGAAGGGAGCCAAGGGATGGACATCTTGTCATTTTTTTTCTT
TGAATAAATGTCACTTTTTGAGGCAAAAGAAGGAACCGTGAACATTTTAGACACCCTTTTCTTTGGGGTAGGCTCTTGCCCCAGGCGCCG
GCTCTTCTCCCAAAAAAAAAAAAAAAACACTAATCCATTTCCCTAACCTAGTAACCTCCAGATCCCAGAGGCTCTCCTCACCTCAGCTGA
GCTCCTTTGAAAGTGATTCAAGGGACTATGTCACTCAGCCTCATTTGCTGGACCAAATCTGGAGGGAGAACCCCTAAAACCCCTAAGTGA
GGTTGCCCAGGGGGTTGTCCCCAGGTGGGGGGAAGCAGGGGAGAGAAAATGGTAGCCATTTTTACATTGTTTTGTATAGTATTTATTGAT

>102457_102457_1_ZNF586-EIF4A1_ZNF586_chr19_58288037_ENST00000391702_EIF4A1_chr17_7478436_ENST00000293831_length(amino acids)=367AA_BP=28
MEEWSLLNEAQRCLYRDVMLETLTLISSLGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGA
SCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSD
VLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQK
ERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMP

--------------------------------------------------------------
>102457_102457_2_ZNF586-EIF4A1_ZNF586_chr19_58288037_ENST00000391702_EIF4A1_chr17_7478436_ENST00000577269_length(transcript)=1510nt_BP=401nt
CTAGCCGTGGCAGCCATTTTGGCCTGTCAGGTCCATCCGGCGATGCTGGGTCTGGACGAGCTCGGGAGGAGTGGTTGTGGCCATTGCACA
CAGGCGGATCTGAGGTTCGGCGACGCCGCTGGTCGCGACCCGGGACAGGACAACGACAGGAACACCGCCGAGCCCGCGTTCCCCCCCCGC
CCAGAGTCATGGCGGCAGCAGCCGCTCTGAGGGCGCCTGCTCAGACTACTGTGGATGATGTCAGCCACATTATGGTGTAAGCCCTAAAGT
TAAGAGCAGTGTGACCTTTGAAGATGTGGCTGTAAACTTTTCCCTGGAGGAATGGAGTCTTCTTAATGAGGCTCAGAGATGCCTGTACCG
TGACGTGATGCTGGAGACCTTGACACTTATATCCTCCCTGGGTTATGATGTGATTGCTCAAGCCCAATCTGGGACTGGGAAAACGGCCAC
ATTTGCCATATCGATTCTGCAGCAGATTGAATTAGATCTAAAAGCCACCCAGGCCTTGGTCCTAGCACCCACTCGAGAATTGGCTCAGCA
GATACAGAAGGTGGTCATGGCACTAGGAGACTACATGGGCGCCTCCTGTCACGCCTGTATCGGGGGCACCAACGTGCGTGCTGAGGTGCA
GAAACTGCAGATGGAAGCTCCCCACATCATCGTGGGTACCCCTGGCCGTGTGTTTGATATGCTTAACCGGAGATACCTGTCCCCCAAATA
CATCAAGATGTTTGTACTGGATGAAGCTGACGAAATGTTAAGCCGTGGATTCAAGGACCAGATCTATGACATATTCCAAAAGCTCAACAG
CAACACCCAGGTAGTTTTGCTGTCAGCCACAATGCCTTCTGATGTGCTTGAGGTGACCAAGAAGTTCATGAGGGACCCCATTCGGATTCT
TGTCAAGAAGGAAGAGTTGACCCTGGAGGGTATCCGCCAGTTCTACATCAACGTGGAACGAGAGGAGTGGAAGCTGGACACACTATGTGA
CTTGTATGAAACCCTGACCATCACCCAGGCAGTCATCTTCATCAACACCCGGAGGAAGGTGGACTGGCTCACCGAGAAGATGCATGCTCG
AGATTTCACTGTATCCGCCATGCATGGAGATATGGACCAAAAGGAACGAGACGTGATTATGAGGGAGTTTCGTTCTGGCTCTAGCAGAGT
TTTGATTACCACTGACCTGCTGGGAAAACTATATCCACAGAATCGGTCGAGGTGGACGGTTTGGCCGTAAAGGTGTGGCTATTAACATGG
TGACAGAAGAAGACAAGAGGACTCTTCGAGACATTGAGACCTTCTACAACACCTCCATTGAGGAAATGCCCCTCAATGTTGCTGACCTCA
TCTGAGGGGCTGTCCTGCCACCCAGCCCCAGCCAGGGCTCAATCTCTGGGGGCTGAGGAGCAGCAGGAGGGGGGAGGGAAGGGAGCCAAG

>102457_102457_2_ZNF586-EIF4A1_ZNF586_chr19_58288037_ENST00000391702_EIF4A1_chr17_7478436_ENST00000577269_length(amino acids)=308AA_BP=28
MEEWSLLNEAQRCLYRDVMLETLTLISSLGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGA
SCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSD
VLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQK

--------------------------------------------------------------
>102457_102457_3_ZNF586-EIF4A1_ZNF586_chr19_58288037_ENST00000391702_EIF4A1_chr17_7478436_ENST00000582746_length(transcript)=1841nt_BP=401nt
CTAGCCGTGGCAGCCATTTTGGCCTGTCAGGTCCATCCGGCGATGCTGGGTCTGGACGAGCTCGGGAGGAGTGGTTGTGGCCATTGCACA
CAGGCGGATCTGAGGTTCGGCGACGCCGCTGGTCGCGACCCGGGACAGGACAACGACAGGAACACCGCCGAGCCCGCGTTCCCCCCCCGC
CCAGAGTCATGGCGGCAGCAGCCGCTCTGAGGGCGCCTGCTCAGACTACTGTGGATGATGTCAGCCACATTATGGTGTAAGCCCTAAAGT
TAAGAGCAGTGTGACCTTTGAAGATGTGGCTGTAAACTTTTCCCTGGAGGAATGGAGTCTTCTTAATGAGGCTCAGAGATGCCTGTACCG
TGACGTGATGCTGGAGACCTTGACACTTATATCCTCCCTGGGTTATGATGTGATTGCTCAAGCCCAATCTGGGACTGGGAAAACGGCCAC
ATTTGCCATATCGATTCTGCAGCAGATTGAATTAGATCTAAAAGCCACCCAGGCCTTGGTCCTAGCACCCACTCGAGAATTGGCTCAGCA
GATACAGAAGGTGGTCATGGCACTAGGAGACTACATGGGCGCCTCCTGTCACGCCTGTATCGGGGGCACCAACGTGCGTGCTGAGGTGCA
GAAACTGCAGATGGAAGCTCCCCACATCATCGTGGGTACCCCTGGCCGTGTGTTTGATATGCTTAACCGGAGATACCTGTCCCCCAAATA
CATCAAGATGTTTGTACTGGATGAAGCTGACGAAATGTTAAGCCGTGGATTCAAGGACCAGATCTATGACATATTCCAAAAGCTCAACAG
CAACACCCAGGTAGTTTTGCTGTCAGCCACAATGCCTTCTGATGTGCTTGAGGTGACCAAGAAGTTCATGAGGGACCCCATTCGGATTCT
TGTCAAGAAGGAAGAGTTGACCCTGGAGGGTATCCGCCAGTTCTACATCAACGTGGAACGAGAGGAGTGGAAGCTGGACACACTATGTGA
CTTGTATGAAACCCTGACCATCACCCAGGCAGTCATCTTCATCAACACCCGGAGGAAGGTGGACTGGCTCACCGAGAAGATGCATGCTCG
AGATTTCACTGTATCCGCCATGCATGGAGATATGGACCAAAAGGAACGAGACGTGATTATGAGGGAGTTTCGTTCTGGCTCTAGCAGAGT
TTTGATTACCACTGACCTGCTGAATCGGTCGAGGTGGACGGTTTGGCCGTAAAGGTGTGGCTATTAACATGGTGACAGAAGAAGACAAGA
GGACTCTTCGAGACATTGAGACCTTCTACAACACCTCCATTGAGGAAATGCCCCTCAATGTTGCTGACCTCATCTGAGGGGCTGTCCTGC
CACCCAGCCCCAGCCAGGGCTCAATCTCTGGGGGCTGAGGAGCAGCAGGAGGGGGGAGGGAAGGGAGCCAAGGGATGGACATCTTGTCAT
TTTTTTTCTTTGAATAAATGTCACTTTTTGAGGCAAAAGAAGGAACCGTGAACATTTTAGACACCCTTTTCTTTGGGGTAGGCTCTTGCC
CCAGGCGCCGGCTCTTCTCCCAAAAAAAAAAAAAAAACACTAATCCATTTCCCTAACCTAGTAACCTCCAGATCCCAGAGGCTCTCCTCA
CCTCAGCTGAGCTCCTTTGAAAGTGATTCAAGGGACTATGTCACTCAGCCTCATTTGCTGGACCAAATCTGGAGGGAGAACCCCTAAAAC
CCCTAAGTGAGGTTGCCCAGGGGGTTGTCCCCAGGTGGGGGGAAGCAGGGGAGAGAAAATGGTAGCCATTTTTACATTGTTTTGTATAGT

>102457_102457_3_ZNF586-EIF4A1_ZNF586_chr19_58288037_ENST00000391702_EIF4A1_chr17_7478436_ENST00000582746_length(amino acids)=302AA_BP=28
MEEWSLLNEAQRCLYRDVMLETLTLISSLGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGA
SCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSD
VLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQK

--------------------------------------------------------------
>102457_102457_4_ZNF586-EIF4A1_ZNF586_chr19_58288037_ENST00000396154_EIF4A1_chr17_7478436_ENST00000293831_length(transcript)=1871nt_BP=336nt
ATTTTGGCCTGTCAGGTCCATCCGGCGATGCTGGGTCTGGACGAGCTCGGGAGGAGTGGTTGTGGCCATTGCACACAGGCGGATCTGAGG
TTCGGCGACGCCGCTGGTCGCGACCCGGGACAGGACAACGACAGGAACACCGCCGAGCCCGCGTTCCCCCCCCGCCCAGAGTCATGGCGG
CAGCAGCCGCTCTGAGGGCGCCTGCTCAGAGCAGTGTGACCTTTGAAGATGTGGCTGTAAACTTTTCCCTGGAGGAATGGAGTCTTCTTA
ATGAGGCTCAGAGATGCCTGTACCGTGACGTGATGCTGGAGACCTTGACACTTATATCCTCCCTGGGTTATGATGTGATTGCTCAAGCCC
AATCTGGGACTGGGAAAACGGCCACATTTGCCATATCGATTCTGCAGCAGATTGAATTAGATCTAAAAGCCACCCAGGCCTTGGTCCTAG
CACCCACTCGAGAATTGGCTCAGCAGATACAGAAGGTGGTCATGGCACTAGGAGACTACATGGGCGCCTCCTGTCACGCCTGTATCGGGG
GCACCAACGTGCGTGCTGAGGTGCAGAAACTGCAGATGGAAGCTCCCCACATCATCGTGGGTACCCCTGGCCGTGTGTTTGATATGCTTA
ACCGGAGATACCTGTCCCCCAAATACATCAAGATGTTTGTACTGGATGAAGCTGACGAAATGTTAAGCCGTGGATTCAAGGACCAGATCT
ATGACATATTCCAAAAGCTCAACAGCAACACCCAGGTAGTTTTGCTGTCAGCCACAATGCCTTCTGATGTGCTTGAGGTGACCAAGAAGT
TCATGAGGGACCCCATTCGGATTCTTGTCAAGAAGGAAGAGTTGACCCTGGAGGGTATCCGCCAGTTCTACATCAACGTGGAACGAGAGG
AGTGGAAGCTGGACACACTATGTGACTTGTATGAAACCCTGACCATCACCCAGGCAGTCATCTTCATCAACACCCGGAGGAAGGTGGACT
GGCTCACCGAGAAGATGCATGCTCGAGATTTCACTGTATCCGCCATGCATGGAGATATGGACCAAAAGGAACGAGACGTGATTATGAGGG
AGTTTCGTTCTGGCTCTAGCAGAGTTTTGATTACCACTGACCTGCTGGCCAGAGGCATTGATGTGCAGCAGGTTTCTTTAGTCATCAACT
ATGACCTTCCCACCAACAGGGAAAACTATATCCACAGAATCGGTCGAGGTGGACGGTTTGGCCGTAAAGGTGTGGCTATTAACATGGTGA
CAGAAGAAGACAAGAGGACTCTTCGAGACATTGAGACCTTCTACAACACCTCCATTGAGGAAATGCCCCTCAATGTTGCTGACCTCATCT
GAGGGGCTGTCCTGCCACCCAGCCCCAGCCAGGGCTCAATCTCTGGGGGCTGAGGAGCAGCAGGAGGGGGGAGGGAAGGGAGCCAAGGGA
TGGACATCTTGTCATTTTTTTTCTTTGAATAAATGTCACTTTTTGAGGCAAAAGAAGGAACCGTGAACATTTTAGACACCCTTTTCTTTG
GGGTAGGCTCTTGCCCCAGGCGCCGGCTCTTCTCCCAAAAAAAAAAAAAAAACACTAATCCATTTCCCTAACCTAGTAACCTCCAGATCC
CAGAGGCTCTCCTCACCTCAGCTGAGCTCCTTTGAAAGTGATTCAAGGGACTATGTCACTCAGCCTCATTTGCTGGACCAAATCTGGAGG
GAGAACCCCTAAAACCCCTAAGTGAGGTTGCCCAGGGGGTTGTCCCCAGGTGGGGGGAAGCAGGGGAGAGAAAATGGTAGCCATTTTTAC

>102457_102457_4_ZNF586-EIF4A1_ZNF586_chr19_58288037_ENST00000396154_EIF4A1_chr17_7478436_ENST00000293831_length(amino acids)=447AA_BP=108
MSGPSGDAGSGRAREEWLWPLHTGGSEVRRRRWSRPGTGQRQEHRRARVPPPPRVMAAAAALRAPAQSSVTFEDVAVNFSLEEWSLLNEA
QRCLYRDVMLETLTLISSLGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTN
VRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMR
DPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFR

--------------------------------------------------------------
>102457_102457_5_ZNF586-EIF4A1_ZNF586_chr19_58288037_ENST00000396154_EIF4A1_chr17_7478436_ENST00000577269_length(transcript)=1445nt_BP=336nt
ATTTTGGCCTGTCAGGTCCATCCGGCGATGCTGGGTCTGGACGAGCTCGGGAGGAGTGGTTGTGGCCATTGCACACAGGCGGATCTGAGG
TTCGGCGACGCCGCTGGTCGCGACCCGGGACAGGACAACGACAGGAACACCGCCGAGCCCGCGTTCCCCCCCCGCCCAGAGTCATGGCGG
CAGCAGCCGCTCTGAGGGCGCCTGCTCAGAGCAGTGTGACCTTTGAAGATGTGGCTGTAAACTTTTCCCTGGAGGAATGGAGTCTTCTTA
ATGAGGCTCAGAGATGCCTGTACCGTGACGTGATGCTGGAGACCTTGACACTTATATCCTCCCTGGGTTATGATGTGATTGCTCAAGCCC
AATCTGGGACTGGGAAAACGGCCACATTTGCCATATCGATTCTGCAGCAGATTGAATTAGATCTAAAAGCCACCCAGGCCTTGGTCCTAG
CACCCACTCGAGAATTGGCTCAGCAGATACAGAAGGTGGTCATGGCACTAGGAGACTACATGGGCGCCTCCTGTCACGCCTGTATCGGGG
GCACCAACGTGCGTGCTGAGGTGCAGAAACTGCAGATGGAAGCTCCCCACATCATCGTGGGTACCCCTGGCCGTGTGTTTGATATGCTTA
ACCGGAGATACCTGTCCCCCAAATACATCAAGATGTTTGTACTGGATGAAGCTGACGAAATGTTAAGCCGTGGATTCAAGGACCAGATCT
ATGACATATTCCAAAAGCTCAACAGCAACACCCAGGTAGTTTTGCTGTCAGCCACAATGCCTTCTGATGTGCTTGAGGTGACCAAGAAGT
TCATGAGGGACCCCATTCGGATTCTTGTCAAGAAGGAAGAGTTGACCCTGGAGGGTATCCGCCAGTTCTACATCAACGTGGAACGAGAGG
AGTGGAAGCTGGACACACTATGTGACTTGTATGAAACCCTGACCATCACCCAGGCAGTCATCTTCATCAACACCCGGAGGAAGGTGGACT
GGCTCACCGAGAAGATGCATGCTCGAGATTTCACTGTATCCGCCATGCATGGAGATATGGACCAAAAGGAACGAGACGTGATTATGAGGG
AGTTTCGTTCTGGCTCTAGCAGAGTTTTGATTACCACTGACCTGCTGGGAAAACTATATCCACAGAATCGGTCGAGGTGGACGGTTTGGC
CGTAAAGGTGTGGCTATTAACATGGTGACAGAAGAAGACAAGAGGACTCTTCGAGACATTGAGACCTTCTACAACACCTCCATTGAGGAA
ATGCCCCTCAATGTTGCTGACCTCATCTGAGGGGCTGTCCTGCCACCCAGCCCCAGCCAGGGCTCAATCTCTGGGGGCTGAGGAGCAGCA
GGAGGGGGGAGGGAAGGGAGCCAAGGGATGGACATCTTGTCATTTTTTTTCTTTGAATAAATGTCACTTTTTGAGGCAAAAGAAGGAACC

>102457_102457_5_ZNF586-EIF4A1_ZNF586_chr19_58288037_ENST00000396154_EIF4A1_chr17_7478436_ENST00000577269_length(amino acids)=388AA_BP=108
MSGPSGDAGSGRAREEWLWPLHTGGSEVRRRRWSRPGTGQRQEHRRARVPPPPRVMAAAAALRAPAQSSVTFEDVAVNFSLEEWSLLNEA
QRCLYRDVMLETLTLISSLGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTN
VRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMR
DPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFR

--------------------------------------------------------------
>102457_102457_6_ZNF586-EIF4A1_ZNF586_chr19_58288037_ENST00000396154_EIF4A1_chr17_7478436_ENST00000582746_length(transcript)=1776nt_BP=336nt
ATTTTGGCCTGTCAGGTCCATCCGGCGATGCTGGGTCTGGACGAGCTCGGGAGGAGTGGTTGTGGCCATTGCACACAGGCGGATCTGAGG
TTCGGCGACGCCGCTGGTCGCGACCCGGGACAGGACAACGACAGGAACACCGCCGAGCCCGCGTTCCCCCCCCGCCCAGAGTCATGGCGG
CAGCAGCCGCTCTGAGGGCGCCTGCTCAGAGCAGTGTGACCTTTGAAGATGTGGCTGTAAACTTTTCCCTGGAGGAATGGAGTCTTCTTA
ATGAGGCTCAGAGATGCCTGTACCGTGACGTGATGCTGGAGACCTTGACACTTATATCCTCCCTGGGTTATGATGTGATTGCTCAAGCCC
AATCTGGGACTGGGAAAACGGCCACATTTGCCATATCGATTCTGCAGCAGATTGAATTAGATCTAAAAGCCACCCAGGCCTTGGTCCTAG
CACCCACTCGAGAATTGGCTCAGCAGATACAGAAGGTGGTCATGGCACTAGGAGACTACATGGGCGCCTCCTGTCACGCCTGTATCGGGG
GCACCAACGTGCGTGCTGAGGTGCAGAAACTGCAGATGGAAGCTCCCCACATCATCGTGGGTACCCCTGGCCGTGTGTTTGATATGCTTA
ACCGGAGATACCTGTCCCCCAAATACATCAAGATGTTTGTACTGGATGAAGCTGACGAAATGTTAAGCCGTGGATTCAAGGACCAGATCT
ATGACATATTCCAAAAGCTCAACAGCAACACCCAGGTAGTTTTGCTGTCAGCCACAATGCCTTCTGATGTGCTTGAGGTGACCAAGAAGT
TCATGAGGGACCCCATTCGGATTCTTGTCAAGAAGGAAGAGTTGACCCTGGAGGGTATCCGCCAGTTCTACATCAACGTGGAACGAGAGG
AGTGGAAGCTGGACACACTATGTGACTTGTATGAAACCCTGACCATCACCCAGGCAGTCATCTTCATCAACACCCGGAGGAAGGTGGACT
GGCTCACCGAGAAGATGCATGCTCGAGATTTCACTGTATCCGCCATGCATGGAGATATGGACCAAAAGGAACGAGACGTGATTATGAGGG
AGTTTCGTTCTGGCTCTAGCAGAGTTTTGATTACCACTGACCTGCTGAATCGGTCGAGGTGGACGGTTTGGCCGTAAAGGTGTGGCTATT
AACATGGTGACAGAAGAAGACAAGAGGACTCTTCGAGACATTGAGACCTTCTACAACACCTCCATTGAGGAAATGCCCCTCAATGTTGCT
GACCTCATCTGAGGGGCTGTCCTGCCACCCAGCCCCAGCCAGGGCTCAATCTCTGGGGGCTGAGGAGCAGCAGGAGGGGGGAGGGAAGGG
AGCCAAGGGATGGACATCTTGTCATTTTTTTTCTTTGAATAAATGTCACTTTTTGAGGCAAAAGAAGGAACCGTGAACATTTTAGACACC
CTTTTCTTTGGGGTAGGCTCTTGCCCCAGGCGCCGGCTCTTCTCCCAAAAAAAAAAAAAAAACACTAATCCATTTCCCTAACCTAGTAAC
CTCCAGATCCCAGAGGCTCTCCTCACCTCAGCTGAGCTCCTTTGAAAGTGATTCAAGGGACTATGTCACTCAGCCTCATTTGCTGGACCA
AATCTGGAGGGAGAACCCCTAAAACCCCTAAGTGAGGTTGCCCAGGGGGTTGTCCCCAGGTGGGGGGAAGCAGGGGAGAGAAAATGGTAG

>102457_102457_6_ZNF586-EIF4A1_ZNF586_chr19_58288037_ENST00000396154_EIF4A1_chr17_7478436_ENST00000582746_length(amino acids)=382AA_BP=108
MSGPSGDAGSGRAREEWLWPLHTGGSEVRRRRWSRPGTGQRQEHRRARVPPPPRVMAAAAALRAPAQSSVTFEDVAVNFSLEEWSLLNEA
QRCLYRDVMLETLTLISSLGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTN
VRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMR
DPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZNF586-EIF4A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF586-EIF4A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF586-EIF4A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource