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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Fusion gene:ZNF592-ZSCAN2 (FusionGDB2 ID:102498)

Fusion Gene Summary for ZNF592-ZSCAN2

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF592-ZSCAN2
Fusion gene ID: 102498
HgeneTgene
Gene symbol

ZNF592

ZSCAN2

Gene ID

9640

54993

Gene namezinc finger protein 592zinc finger and SCAN domain containing 2
SynonymsCAMOS|SCAR5ZFP29|ZNF854
Cytomap

15q25.3

15q25.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 592zinc finger and SCAN domain-containing protein 2zfp-29zinc finger protein 29 homologzinc finger protein 854
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000299927, ENST00000560079, 
ENST00000358472, ENST00000303310, 
ENST00000327179, ENST00000334141, 
ENST00000379358, ENST00000485222, 
ENST00000538076, ENST00000541040, 
ENST00000448803, ENST00000546148, 
Fusion gene scores* DoF score5 X 5 X 3=753 X 3 X 3=27
# samples 53
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZNF592 [Title/Abstract] AND ZSCAN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF592(85326045)-ZSCAN2(85163833), # samples:2
Anticipated loss of major functional domain due to fusion event.ZNF592-ZSCAN2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ZNF592-ZSCAN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ZNF592-ZSCAN2 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ZNF592-ZSCAN2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
ZNF592-ZSCAN2 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ZNF592 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZSCAN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-C8-A137-01AZNF592chr15

85326045

+ZSCAN2chr15

85163833

+


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Fusion Gene ORF analysis for ZNF592-ZSCAN2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000299927ENST00000358472ZNF592chr15

85326045

+ZSCAN2chr15

85163833

+
5CDS-5UTRENST00000560079ENST00000358472ZNF592chr15

85326045

+ZSCAN2chr15

85163833

+
5CDS-intronENST00000299927ENST00000303310ZNF592chr15

85326045

+ZSCAN2chr15

85163833

+
5CDS-intronENST00000299927ENST00000327179ZNF592chr15

85326045

+ZSCAN2chr15

85163833

+
5CDS-intronENST00000299927ENST00000334141ZNF592chr15

85326045

+ZSCAN2chr15

85163833

+
5CDS-intronENST00000299927ENST00000379358ZNF592chr15

85326045

+ZSCAN2chr15

85163833

+
5CDS-intronENST00000299927ENST00000485222ZNF592chr15

85326045

+ZSCAN2chr15

85163833

+
5CDS-intronENST00000299927ENST00000538076ZNF592chr15

85326045

+ZSCAN2chr15

85163833

+
5CDS-intronENST00000299927ENST00000541040ZNF592chr15

85326045

+ZSCAN2chr15

85163833

+
5CDS-intronENST00000560079ENST00000303310ZNF592chr15

85326045

+ZSCAN2chr15

85163833

+
5CDS-intronENST00000560079ENST00000327179ZNF592chr15

85326045

+ZSCAN2chr15

85163833

+
5CDS-intronENST00000560079ENST00000334141ZNF592chr15

85326045

+ZSCAN2chr15

85163833

+
5CDS-intronENST00000560079ENST00000379358ZNF592chr15

85326045

+ZSCAN2chr15

85163833

+
5CDS-intronENST00000560079ENST00000485222ZNF592chr15

85326045

+ZSCAN2chr15

85163833

+
5CDS-intronENST00000560079ENST00000538076ZNF592chr15

85326045

+ZSCAN2chr15

85163833

+
5CDS-intronENST00000560079ENST00000541040ZNF592chr15

85326045

+ZSCAN2chr15

85163833

+
Frame-shiftENST00000299927ENST00000448803ZNF592chr15

85326045

+ZSCAN2chr15

85163833

+
Frame-shiftENST00000560079ENST00000448803ZNF592chr15

85326045

+ZSCAN2chr15

85163833

+
In-frameENST00000299927ENST00000546148ZNF592chr15

85326045

+ZSCAN2chr15

85163833

+
In-frameENST00000560079ENST00000546148ZNF592chr15

85326045

+ZSCAN2chr15

85163833

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000560079ZNF592chr1585326045+ENST00000546148ZSCAN2chr1585163833+395723502712574767
ENST00000299927ZNF592chr1585326045+ENST00000546148ZSCAN2chr1585163833+3688208122305767

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000560079ENST00000546148ZNF592chr1585326045+ZSCAN2chr1585163833+0.0080481530.9919518
ENST00000299927ENST00000546148ZNF592chr1585326045+ZSCAN2chr1585163833+0.0083897940.9916102

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Fusion Genomic Features for ZNF592-ZSCAN2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF592-ZSCAN2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:85326045/chr15:85163833)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZSCAN2chr15:85326045chr15:85163833ENST000003341410359_1320151.0DomainSCAN box
TgeneZSCAN2chr15:85326045chr15:85163833ENST000003793580359_1320147.0DomainSCAN box
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000032717913222_244134614.0Zinc fingerC2H2-type 1
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000032717913250_272134614.0Zinc fingerC2H2-type 2
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000032717913278_300134614.0Zinc fingerC2H2-type 3
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000032717913306_328134614.0Zinc fingerC2H2-type 4
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000032717913334_356134614.0Zinc fingerC2H2-type 5
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000032717913362_384134614.0Zinc fingerC2H2-type 6
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000032717913390_412134614.0Zinc fingerC2H2-type 7
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000032717913418_440134614.0Zinc fingerC2H2-type 8
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000032717913446_468134614.0Zinc fingerC2H2-type 9
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000032717913474_496134614.0Zinc fingerC2H2-type 10
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000032717913502_524134614.0Zinc fingerC2H2-type 11
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000032717913530_552134614.0Zinc fingerC2H2-type 12
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000032717913558_580134614.0Zinc fingerC2H2-type 13
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000032717913586_608134614.0Zinc fingerC2H2-type 14
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000033414103222_2440151.0Zinc fingerC2H2-type 1
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000033414103250_2720151.0Zinc fingerC2H2-type 2
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000033414103278_3000151.0Zinc fingerC2H2-type 3
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000033414103306_3280151.0Zinc fingerC2H2-type 4
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000033414103334_3560151.0Zinc fingerC2H2-type 5
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000033414103362_3840151.0Zinc fingerC2H2-type 6
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000033414103390_4120151.0Zinc fingerC2H2-type 7
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000033414103418_4400151.0Zinc fingerC2H2-type 8
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000033414103446_4680151.0Zinc fingerC2H2-type 9
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000033414103474_4960151.0Zinc fingerC2H2-type 10
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000033414103502_5240151.0Zinc fingerC2H2-type 11
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000033414103530_5520151.0Zinc fingerC2H2-type 12
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000033414103558_5800151.0Zinc fingerC2H2-type 13
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000033414103586_6080151.0Zinc fingerC2H2-type 14
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000037935803222_2440147.0Zinc fingerC2H2-type 1
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000037935803250_2720147.0Zinc fingerC2H2-type 2
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000037935803278_3000147.0Zinc fingerC2H2-type 3
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000037935803306_3280147.0Zinc fingerC2H2-type 4
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000037935803334_3560147.0Zinc fingerC2H2-type 5
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000037935803362_3840147.0Zinc fingerC2H2-type 6
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000037935803390_4120147.0Zinc fingerC2H2-type 7
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000037935803418_4400147.0Zinc fingerC2H2-type 8
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000037935803446_4680147.0Zinc fingerC2H2-type 9
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000037935803474_4960147.0Zinc fingerC2H2-type 10
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000037935803502_5240147.0Zinc fingerC2H2-type 11
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000037935803530_5520147.0Zinc fingerC2H2-type 12
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000037935803558_5800147.0Zinc fingerC2H2-type 13
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000037935803586_6080147.0Zinc fingerC2H2-type 14
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000044880313222_244135615.0Zinc fingerC2H2-type 1
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000044880313250_272135615.0Zinc fingerC2H2-type 2
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000044880313278_300135615.0Zinc fingerC2H2-type 3
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000044880313306_328135615.0Zinc fingerC2H2-type 4
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000044880313334_356135615.0Zinc fingerC2H2-type 5
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000044880313362_384135615.0Zinc fingerC2H2-type 6
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000044880313390_412135615.0Zinc fingerC2H2-type 7
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000044880313418_440135615.0Zinc fingerC2H2-type 8
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000044880313446_468135615.0Zinc fingerC2H2-type 9
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000044880313474_496135615.0Zinc fingerC2H2-type 10
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000044880313502_524135615.0Zinc fingerC2H2-type 11
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000044880313530_552135615.0Zinc fingerC2H2-type 12
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000044880313558_580135615.0Zinc fingerC2H2-type 13
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000044880313586_608135615.0Zinc fingerC2H2-type 14
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000054614813222_244135615.0Zinc fingerC2H2-type 1
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000054614813250_272135615.0Zinc fingerC2H2-type 2
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000054614813278_300135615.0Zinc fingerC2H2-type 3
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000054614813306_328135615.0Zinc fingerC2H2-type 4
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000054614813334_356135615.0Zinc fingerC2H2-type 5
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000054614813362_384135615.0Zinc fingerC2H2-type 6
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000054614813390_412135615.0Zinc fingerC2H2-type 7
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000054614813418_440135615.0Zinc fingerC2H2-type 8
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000054614813446_468135615.0Zinc fingerC2H2-type 9
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000054614813474_496135615.0Zinc fingerC2H2-type 10
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000054614813502_524135615.0Zinc fingerC2H2-type 11
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000054614813530_552135615.0Zinc fingerC2H2-type 12
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000054614813558_580135615.0Zinc fingerC2H2-type 13
TgeneZSCAN2chr15:85326045chr15:85163833ENST0000054614813586_608135615.0Zinc fingerC2H2-type 14

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF592chr15:85326045chr15:85163833ENST00000299927+181013_103601268.0Zinc fingerC2H2-type 10
HgeneZNF592chr15:85326045chr15:85163833ENST00000299927+181043_106901268.0Zinc fingerC2H2-type 11%3B atypical
HgeneZNF592chr15:85326045chr15:85163833ENST00000299927+181124_114601268.0Zinc fingerC2H2-type 12%3B atypical
HgeneZNF592chr15:85326045chr15:85163833ENST00000299927+181153_117601268.0Zinc fingerC2H2-type 13
HgeneZNF592chr15:85326045chr15:85163833ENST00000299927+18587_61201268.0Zinc fingerC2H2-type 1%3B atypical
HgeneZNF592chr15:85326045chr15:85163833ENST00000299927+18615_63901268.0Zinc fingerC2H2-type 2%3B atypical
HgeneZNF592chr15:85326045chr15:85163833ENST00000299927+18711_73101268.0Zinc fingerC2H2-type 3%3B degenerate
HgeneZNF592chr15:85326045chr15:85163833ENST00000299927+18740_76401268.0Zinc fingerC2H2-type 4
HgeneZNF592chr15:85326045chr15:85163833ENST00000299927+18768_79001268.0Zinc fingerC2H2-type 5%3B atypical
HgeneZNF592chr15:85326045chr15:85163833ENST00000299927+18799_82201268.0Zinc fingerC2H2-type 6
HgeneZNF592chr15:85326045chr15:85163833ENST00000299927+18827_85001268.0Zinc fingerC2H2-type 7
HgeneZNF592chr15:85326045chr15:85163833ENST00000299927+18892_91501268.0Zinc fingerC2H2-type 8
HgeneZNF592chr15:85326045chr15:85163833ENST00000299927+18983_100601268.0Zinc fingerC2H2-type 9
HgeneZNF592chr15:85326045chr15:85163833ENST00000560079+1111013_103601268.0Zinc fingerC2H2-type 10
HgeneZNF592chr15:85326045chr15:85163833ENST00000560079+1111043_106901268.0Zinc fingerC2H2-type 11%3B atypical
HgeneZNF592chr15:85326045chr15:85163833ENST00000560079+1111124_114601268.0Zinc fingerC2H2-type 12%3B atypical
HgeneZNF592chr15:85326045chr15:85163833ENST00000560079+1111153_117601268.0Zinc fingerC2H2-type 13
HgeneZNF592chr15:85326045chr15:85163833ENST00000560079+111587_61201268.0Zinc fingerC2H2-type 1%3B atypical
HgeneZNF592chr15:85326045chr15:85163833ENST00000560079+111615_63901268.0Zinc fingerC2H2-type 2%3B atypical
HgeneZNF592chr15:85326045chr15:85163833ENST00000560079+111711_73101268.0Zinc fingerC2H2-type 3%3B degenerate
HgeneZNF592chr15:85326045chr15:85163833ENST00000560079+111740_76401268.0Zinc fingerC2H2-type 4
HgeneZNF592chr15:85326045chr15:85163833ENST00000560079+111768_79001268.0Zinc fingerC2H2-type 5%3B atypical
HgeneZNF592chr15:85326045chr15:85163833ENST00000560079+111799_82201268.0Zinc fingerC2H2-type 6
HgeneZNF592chr15:85326045chr15:85163833ENST00000560079+111827_85001268.0Zinc fingerC2H2-type 7
HgeneZNF592chr15:85326045chr15:85163833ENST00000560079+111892_91501268.0Zinc fingerC2H2-type 8
HgeneZNF592chr15:85326045chr15:85163833ENST00000560079+111983_100601268.0Zinc fingerC2H2-type 9
TgeneZSCAN2chr15:85326045chr15:85163833ENST000003271791359_132134614.0DomainSCAN box
TgeneZSCAN2chr15:85326045chr15:85163833ENST000004488031359_132135615.0DomainSCAN box
TgeneZSCAN2chr15:85326045chr15:85163833ENST000005461481359_132135615.0DomainSCAN box


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Fusion Gene Sequence for ZNF592-ZSCAN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>102498_102498_1_ZNF592-ZSCAN2_ZNF592_chr15_85326045_ENST00000299927_ZSCAN2_chr15_85163833_ENST00000546148_length(transcript)=3688nt_BP=2081nt
GTATGGATGAAAGTGTGTCCTTGTCTCACTCAGGATCAGCCCCCGATGTGCCGGCCGTGAGTGTCATTGTCAAGAACACCAGCCGCCAGG
AGTCATTTGAAGCGGAGAAAGACCACATTACTCCCAGTCTCCTACACAATGGATTCCGGGGCTCAGATCTGCCTCCAGATCCCCACAACT
GTGGGAAATTTGATTCTACTTTTATGAATGGAGACAGTGCCAGGAGTTTCCCTGGCAAACTGGAGCCTCCCAAGTCAGAGCCATTACCCA
CCTTCAACCAGTTCAGTCCAATCTCCAGCCCAGAACCTGAGGATCCCATCAAAGATAACGGATTTGGGATAAAGCCCAAACACTCTGACA
GTTATTTCCCACCCCCTCTTGGGTGCGGGGCTGTGGGAGGCCCAGTCCTGGAGGCTCTGGCTAAGTTTCCGGTTCCAGAGCTGCATATGT
TTGATCATTTTTGTAAGAAAGAACCCAAGCCAGAACCCCTGCCCTTGGGGAGCCAGCAGGAACACGAGCAAAGTGGGCAGAACACAGTGG
AACCTCACAAGGATCCGGATGCCACTCGATTCTTCGGGGAAGCTTTGGAGTTCAACAGCCATCCTAGCAACAGTATTGGAGAGTCCAAGG
GGCTTGCCCGGGAGCTTGGTACCTGCTCATCAGTCCCCCCTAGGCAGCGTCTAAAGCCAGCTCATTCCAAGCTGTCCTCTTGTGTGGCAG
CCTTGGTGGCCTTGCAGGCCAAAAGAGTGGCTAGTGTCACTAAGGAGGATCAGCCTGGCCACACAAAGGATCTCTCAGGGCCCACTAAAG
AGAGTTCTAAAGGTAGCCCCAAAATGCCCAAGTCACCAAAGAGTCCCCGGAGCCCTCTGGAGGCCACTAGAAAAAGTATCAAGCCATCGG
ACAGCCCTCGTAGCATCTGCAGTGACAGCAGCAGCAAAGGCTCACCGTCTGTGGCTGCCAGCTCCCCACCAGCAATTCCCAAAGTGAGAA
TCAAAACCATTAAGACATCATCAGGGGAAATCAAACGGACTGTCACAAGGATCCTGCCAGATCCTGATGATCCAAGTAAGTCCCCTGTTG
GGTCACCTCTAGGGAGCGCCATTGCAGAGGCCCCCAGCGAGATGCCAGGGGATGAGGTGCCTGTGGAAGAGCACTTTCCTGAGGCAGGCA
CAAATTCAGGGAGCCCCCAGGGGGCCAGGAAAGGGGACGAGAGCATGACAAAGGCCAGTGACTCGTCATCTCCCAGCTGCAGTTCTGGGC
CCCGGGTCCCAAAGGGGGCTGCCCCAGGCTCACAGACAGGCAAGAAGCAACAGAGCACAGCACTGCAGGCATCCACCCTGGCCCCTGCCA
ACCTCCTGCCCAAAGCCGTGCACTTGGCCAACCTGAACCTCGTCCCCCACAGTGTTGCTGCATCAGTGACAGCCAAGTCTTCAGTGCAAA
GACGGAGCCAGCCACAGCTTACACAAATGTCGGTGCCCCTGGTCCACCAGGTGAAAAAGGCTGCCCCACTGATTGTAGAGGTCTTCAACA
AGGTCCTTCACAGCTCCAACCCCGTGCCCCTCTATGCGCCAAATCTCAGCCCGCCTGCGGACAGCAGGATCCACGTGCCGGCCAGTGGGT
ACTGCTGCCTGGAGTGTGGAGACGCATTTGCCTTAGAGAAGAGCCTGAGCCAGCACTATGGCCGGCGGAGCGTCCACATTGAGGTACTGT
GCACACTGTGCTCCAAGACGCTGCTCTTCTTCAACAAGTGCAGCCTGCTCCGGCACGCCCGTGACCACAAGAGCAAGGGGCTCGTCATGC
AGTGTTCCCAGCTGCTGGTGAAGCCTATCTCTGCGGACCAAATGTTCGTGTCGGCCCCTGTGAACTCCACGGCACCAGCAGCCCCAGCCC
CTTCATCCTCTCCCAAACATGGCCTCACTTCGGGCAGTGCCAGTCCCCCTCCTCCAGCCTTGCCACTCTACCCAGACCCTGTGAGGCTCA
TCCGGTACTCAATCAAGTGTCTTGAATGTCACAAGCAGATGCGGGACTACATGGTCCTGGCTGCACATTTCCAGAGGACAACAGAGGAGA
CAGAGGGGCTGATTTTGAGATACAGAGTGAAAATGGGGAGAACTGTAATCAAGACATGTTTGAGAATGAATCACGTAAGATATTCTCGGA
AATGCCTGAAGGTGAAAGTGCTCAGCACTCCGATGGGGAAAGTGACTTTGAGAGAGATGCTGGCATCCAGAGGCTCCAGGGACACAGCCC
AGGTGAGGACCACGGGGAGGTGGTTTCTCAGGACAGGGAAGTTGGCCAGCTCATAGGCCTGCAGGGCACCTACCTAGGGGAGAAGCCCTA
CGAATGTCCCCAGTGTGGGAAGACCTTCAGCCGGAAATCCCACCTCATCACACACGAGAGGACCCACACAGGAGAGAAATACTACAAATG
TGATGAATGTGGAAAAAGCTTTAGTGATGGTTCAAATTTTAGTAGACACCAAACCACTCACACCGGGGAGAAGCCCTACAAATGCAGAGA
CTGTGGGAAGAGCTTTAGCCGGAGTGCCAACCTCATAACCCACCAGAGGATCCACACGGGGGAAAAGCCCTTCCAGTGTGCCGAGTGTGG
CAAGAGCTTCAGCAGGAGTCCCAACCTCATTGCACATCAGCGCACCCACACAGGAGAGAAACCCTACTCGTGCCCCGAGTGTGGAAAGAG
CTTTGGCAACCGATCCAGCCTTAACACGCATCAGGGGATCCACACTGGAGAAAAGCCCTACGAATGTAAAGAATGCGGCGAAAGCTTTAG
TTACAACTCCAATCTAATCAGACACCAGAGAATCCACACAGGAGAGAAACCCTACAAATGTACCGACTGTGGGCAGAGGTTCAGCCAGAG
TTCAGCCCTCATCACCCACCGGAGAACCCACACAGGAGAGAAACCCTACCAGTGCAGCGAGTGTGGGAAAAGCTTCAGCCGCAGCTCTAA
CCTGGCCACACACCGGAGAACCCACATGGTGGAGAAGCCCTATAAGTGTGGGGTGTGTGGGAAGAGCTTCAGCCAGAGCTCCAGTCTGAT
TGCACACCAGGGCATGCACACAGGGGAGAAACCCTACGAGTGCCTGACATGTGGGGAGAGCTTCAGCTGGAGCTCCAACCTCCTCAAGCA
CCAGAGGATCCACACGGGAGAGAAACCCTACAAATGCAGCGAGTGTGGGAAATGCTTCAGCCAGCGCTCCCAGCTCGTAGTGCACCAGCG
GACCCACACGGGCGAGAAGCCCTACAAATGCCTCATGTGCGGCAAGAGCTTCAGCCGGGGCTCCATTCTGGTCATGCACCAGAGAGCCCA
TTTGGGAGACAAGCCCTACAGGTGCCCTGAGTGTGGGAAAGGCTTTAGCTGGAACTCAGTCCTCATTATACATCAGCGAATCCACACTGG
GGAGAAGCCCTACAAATGCCCCGAGTGTGGCAAAGGCTTCAGCAACAGCTCTAACTTTATCACACATCAGAGAACTCACATGAAAGAGAA
ACTTTATTGAAGTGGCAAAGAGTGAAAGTGAGGGACTGGCCTGGAGTGGGAGTTGCCACACTGCCCCAACAGTGATTCCCTTTCAAAGAG

>102498_102498_1_ZNF592-ZSCAN2_ZNF592_chr15_85326045_ENST00000299927_ZSCAN2_chr15_85163833_ENST00000546148_length(amino acids)=767AA_BP=693
MDESVSLSHSGSAPDVPAVSVIVKNTSRQESFEAEKDHITPSLLHNGFRGSDLPPDPHNCGKFDSTFMNGDSARSFPGKLEPPKSEPLPT
FNQFSPISSPEPEDPIKDNGFGIKPKHSDSYFPPPLGCGAVGGPVLEALAKFPVPELHMFDHFCKKEPKPEPLPLGSQQEHEQSGQNTVE
PHKDPDATRFFGEALEFNSHPSNSIGESKGLARELGTCSSVPPRQRLKPAHSKLSSCVAALVALQAKRVASVTKEDQPGHTKDLSGPTKE
SSKGSPKMPKSPKSPRSPLEATRKSIKPSDSPRSICSDSSSKGSPSVAASSPPAIPKVRIKTIKTSSGEIKRTVTRILPDPDDPSKSPVG
SPLGSAIAEAPSEMPGDEVPVEEHFPEAGTNSGSPQGARKGDESMTKASDSSSPSCSSGPRVPKGAAPGSQTGKKQQSTALQASTLAPAN
LLPKAVHLANLNLVPHSVAASVTAKSSVQRRSQPQLTQMSVPLVHQVKKAAPLIVEVFNKVLHSSNPVPLYAPNLSPPADSRIHVPASGY
CCLECGDAFALEKSLSQHYGRRSVHIEVLCTLCSKTLLFFNKCSLLRHARDHKSKGLVMQCSQLLVKPISADQMFVSAPVNSTAPAAPAP
SSSPKHGLTSGSASPPPPALPLYPDPVRLIRYSIKCLECHKQMRDYMVLAAHFQRTTEETEGLILRYRVKMGRTVIKTCLRMNHVRYSRK

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>102498_102498_2_ZNF592-ZSCAN2_ZNF592_chr15_85326045_ENST00000560079_ZSCAN2_chr15_85163833_ENST00000546148_length(transcript)=3957nt_BP=2350nt
CTGGCCTGCAGTCGCCGCCGCCGCCGCCAGGTGGTGTTTGGACTCTAGACCATGTGCCTAGGTAGAAGTTTTTCCTTTCTCCGCAGCTCT
GCTCCCCTAGCAACGCTCGCCACACCCTTGTTTTGAGATCCTCTCTAAGGAGCGGAGAGTTTAATAGGCAAGAAGGAAGGGAGAAGACAG
AAGGAAGACGCTCCCCCGTACGGAGACAGAGGGAGGGGGGGCTCCAAAGCCGAAAGAGGAGGTCCCTACCTGCCACGGATACCAGTCAGG
TATGGATGAAAGTGTGTCCTTGTCTCACTCAGGATCAGCCCCCGATGTGCCGGCCGTGAGTGTCATTGTCAAGAACACCAGCCGCCAGGA
GTCATTTGAAGCGGAGAAAGACCACATTACTCCCAGTCTCCTACACAATGGATTCCGGGGCTCAGATCTGCCTCCAGATCCCCACAACTG
TGGGAAATTTGATTCTACTTTTATGAATGGAGACAGTGCCAGGAGTTTCCCTGGCAAACTGGAGCCTCCCAAGTCAGAGCCATTACCCAC
CTTCAACCAGTTCAGTCCAATCTCCAGCCCAGAACCTGAGGATCCCATCAAAGATAACGGATTTGGGATAAAGCCCAAACACTCTGACAG
TTATTTCCCACCCCCTCTTGGGTGCGGGGCTGTGGGAGGCCCAGTCCTGGAGGCTCTGGCTAAGTTTCCGGTTCCAGAGCTGCATATGTT
TGATCATTTTTGTAAGAAAGAACCCAAGCCAGAACCCCTGCCCTTGGGGAGCCAGCAGGAACACGAGCAAAGTGGGCAGAACACAGTGGA
ACCTCACAAGGATCCGGATGCCACTCGATTCTTCGGGGAAGCTTTGGAGTTCAACAGCCATCCTAGCAACAGTATTGGAGAGTCCAAGGG
GCTTGCCCGGGAGCTTGGTACCTGCTCATCAGTCCCCCCTAGGCAGCGTCTAAAGCCAGCTCATTCCAAGCTGTCCTCTTGTGTGGCAGC
CTTGGTGGCCTTGCAGGCCAAAAGAGTGGCTAGTGTCACTAAGGAGGATCAGCCTGGCCACACAAAGGATCTCTCAGGGCCCACTAAAGA
GAGTTCTAAAGGTAGCCCCAAAATGCCCAAGTCACCAAAGAGTCCCCGGAGCCCTCTGGAGGCCACTAGAAAAAGTATCAAGCCATCGGA
CAGCCCTCGTAGCATCTGCAGTGACAGCAGCAGCAAAGGCTCACCGTCTGTGGCTGCCAGCTCCCCACCAGCAATTCCCAAAGTGAGAAT
CAAAACCATTAAGACATCATCAGGGGAAATCAAACGGACTGTCACAAGGATCCTGCCAGATCCTGATGATCCAAGTAAGTCCCCTGTTGG
GTCACCTCTAGGGAGCGCCATTGCAGAGGCCCCCAGCGAGATGCCAGGGGATGAGGTGCCTGTGGAAGAGCACTTTCCTGAGGCAGGCAC
AAATTCAGGGAGCCCCCAGGGGGCCAGGAAAGGGGACGAGAGCATGACAAAGGCCAGTGACTCGTCATCTCCCAGCTGCAGTTCTGGGCC
CCGGGTCCCAAAGGGGGCTGCCCCAGGCTCACAGACAGGCAAGAAGCAACAGAGCACAGCACTGCAGGCATCCACCCTGGCCCCTGCCAA
CCTCCTGCCCAAAGCCGTGCACTTGGCCAACCTGAACCTCGTCCCCCACAGTGTTGCTGCATCAGTGACAGCCAAGTCTTCAGTGCAAAG
ACGGAGCCAGCCACAGCTTACACAAATGTCGGTGCCCCTGGTCCACCAGGTGAAAAAGGCTGCCCCACTGATTGTAGAGGTCTTCAACAA
GGTCCTTCACAGCTCCAACCCCGTGCCCCTCTATGCGCCAAATCTCAGCCCGCCTGCGGACAGCAGGATCCACGTGCCGGCCAGTGGGTA
CTGCTGCCTGGAGTGTGGAGACGCATTTGCCTTAGAGAAGAGCCTGAGCCAGCACTATGGCCGGCGGAGCGTCCACATTGAGGTACTGTG
CACACTGTGCTCCAAGACGCTGCTCTTCTTCAACAAGTGCAGCCTGCTCCGGCACGCCCGTGACCACAAGAGCAAGGGGCTCGTCATGCA
GTGTTCCCAGCTGCTGGTGAAGCCTATCTCTGCGGACCAAATGTTCGTGTCGGCCCCTGTGAACTCCACGGCACCAGCAGCCCCAGCCCC
TTCATCCTCTCCCAAACATGGCCTCACTTCGGGCAGTGCCAGTCCCCCTCCTCCAGCCTTGCCACTCTACCCAGACCCTGTGAGGCTCAT
CCGGTACTCAATCAAGTGTCTTGAATGTCACAAGCAGATGCGGGACTACATGGTCCTGGCTGCACATTTCCAGAGGACAACAGAGGAGAC
AGAGGGGCTGATTTTGAGATACAGAGTGAAAATGGGGAGAACTGTAATCAAGACATGTTTGAGAATGAATCACGTAAGATATTCTCGGAA
ATGCCTGAAGGTGAAAGTGCTCAGCACTCCGATGGGGAAAGTGACTTTGAGAGAGATGCTGGCATCCAGAGGCTCCAGGGACACAGCCCA
GGTGAGGACCACGGGGAGGTGGTTTCTCAGGACAGGGAAGTTGGCCAGCTCATAGGCCTGCAGGGCACCTACCTAGGGGAGAAGCCCTAC
GAATGTCCCCAGTGTGGGAAGACCTTCAGCCGGAAATCCCACCTCATCACACACGAGAGGACCCACACAGGAGAGAAATACTACAAATGT
GATGAATGTGGAAAAAGCTTTAGTGATGGTTCAAATTTTAGTAGACACCAAACCACTCACACCGGGGAGAAGCCCTACAAATGCAGAGAC
TGTGGGAAGAGCTTTAGCCGGAGTGCCAACCTCATAACCCACCAGAGGATCCACACGGGGGAAAAGCCCTTCCAGTGTGCCGAGTGTGGC
AAGAGCTTCAGCAGGAGTCCCAACCTCATTGCACATCAGCGCACCCACACAGGAGAGAAACCCTACTCGTGCCCCGAGTGTGGAAAGAGC
TTTGGCAACCGATCCAGCCTTAACACGCATCAGGGGATCCACACTGGAGAAAAGCCCTACGAATGTAAAGAATGCGGCGAAAGCTTTAGT
TACAACTCCAATCTAATCAGACACCAGAGAATCCACACAGGAGAGAAACCCTACAAATGTACCGACTGTGGGCAGAGGTTCAGCCAGAGT
TCAGCCCTCATCACCCACCGGAGAACCCACACAGGAGAGAAACCCTACCAGTGCAGCGAGTGTGGGAAAAGCTTCAGCCGCAGCTCTAAC
CTGGCCACACACCGGAGAACCCACATGGTGGAGAAGCCCTATAAGTGTGGGGTGTGTGGGAAGAGCTTCAGCCAGAGCTCCAGTCTGATT
GCACACCAGGGCATGCACACAGGGGAGAAACCCTACGAGTGCCTGACATGTGGGGAGAGCTTCAGCTGGAGCTCCAACCTCCTCAAGCAC
CAGAGGATCCACACGGGAGAGAAACCCTACAAATGCAGCGAGTGTGGGAAATGCTTCAGCCAGCGCTCCCAGCTCGTAGTGCACCAGCGG
ACCCACACGGGCGAGAAGCCCTACAAATGCCTCATGTGCGGCAAGAGCTTCAGCCGGGGCTCCATTCTGGTCATGCACCAGAGAGCCCAT
TTGGGAGACAAGCCCTACAGGTGCCCTGAGTGTGGGAAAGGCTTTAGCTGGAACTCAGTCCTCATTATACATCAGCGAATCCACACTGGG
GAGAAGCCCTACAAATGCCCCGAGTGTGGCAAAGGCTTCAGCAACAGCTCTAACTTTATCACACATCAGAGAACTCACATGAAAGAGAAA
CTTTATTGAAGTGGCAAAGAGTGAAAGTGAGGGACTGGCCTGGAGTGGGAGTTGCCACACTGCCCCAACAGTGATTCCCTTTCAAAGAGC

>102498_102498_2_ZNF592-ZSCAN2_ZNF592_chr15_85326045_ENST00000560079_ZSCAN2_chr15_85163833_ENST00000546148_length(amino acids)=767AA_BP=693
MDESVSLSHSGSAPDVPAVSVIVKNTSRQESFEAEKDHITPSLLHNGFRGSDLPPDPHNCGKFDSTFMNGDSARSFPGKLEPPKSEPLPT
FNQFSPISSPEPEDPIKDNGFGIKPKHSDSYFPPPLGCGAVGGPVLEALAKFPVPELHMFDHFCKKEPKPEPLPLGSQQEHEQSGQNTVE
PHKDPDATRFFGEALEFNSHPSNSIGESKGLARELGTCSSVPPRQRLKPAHSKLSSCVAALVALQAKRVASVTKEDQPGHTKDLSGPTKE
SSKGSPKMPKSPKSPRSPLEATRKSIKPSDSPRSICSDSSSKGSPSVAASSPPAIPKVRIKTIKTSSGEIKRTVTRILPDPDDPSKSPVG
SPLGSAIAEAPSEMPGDEVPVEEHFPEAGTNSGSPQGARKGDESMTKASDSSSPSCSSGPRVPKGAAPGSQTGKKQQSTALQASTLAPAN
LLPKAVHLANLNLVPHSVAASVTAKSSVQRRSQPQLTQMSVPLVHQVKKAAPLIVEVFNKVLHSSNPVPLYAPNLSPPADSRIHVPASGY
CCLECGDAFALEKSLSQHYGRRSVHIEVLCTLCSKTLLFFNKCSLLRHARDHKSKGLVMQCSQLLVKPISADQMFVSAPVNSTAPAAPAP
SSSPKHGLTSGSASPPPPALPLYPDPVRLIRYSIKCLECHKQMRDYMVLAAHFQRTTEETEGLILRYRVKMGRTVIKTCLRMNHVRYSRK

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Fusion Gene PPI Analysis for ZNF592-ZSCAN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF592-ZSCAN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF592-ZSCAN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource