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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ZNF599-SCN1B (FusionGDB2 ID:102514)

Fusion Gene Summary for ZNF599-SCN1B

Fusion gene summary

Fusion gene information	Fusion gene name: ZNF599-SCN1B
	Fusion gene ID: 102514
		Hgene	Tgene
	Gene symbol	ZNF599	SCN1B
	Gene ID	148103	6324
	Gene name	zinc finger protein 599	sodium voltage-gated channel beta subunit 1
	Synonyms	-	ATFB13\|BRGDA5\|EIEE52\|GEFSP1
	Cytomap	19q13.11	19q13.11
	Type of gene	protein-coding	protein-coding
	Description	zinc finger protein 599	sodium channel subunit beta-1sodium channel, voltage gated, type I beta subunitsodium channel, voltage-gated, type I, beta
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000329285, ENST00000587354, ENST00000588760,	ENST00000596348, ENST00000262631, ENST00000415950, ENST00000595652,
Fusion gene scores	* DoF score	2 X 1 X 2=4	4 X 2 X 4=32
	# samples	2	5
	** MAII score	log2(2/4*10)=2.32192809488736	log2(5/32*10)=0.643856189774725 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: ZNF599 [Title/Abstract] AND SCN1B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ZNF599(35258221)-SCN1B(35523432), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	SCN1B	GO:0010765	positive regulation of sodium ion transport	19808477
Tgene	SCN1B	GO:0035725	sodium ion transmembrane transport	18464934\|19808477\|21051419
Tgene	SCN1B	GO:0051899	membrane depolarization	21051419
Tgene	SCN1B	GO:2000649	regulation of sodium ion transmembrane transporter activity	19808477

Fusion gene breakpoints across ZNF599 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SCN1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-43-7657-01A	ZNF599	chr19	35258221	-	SCN1B	chr19	35523432	+

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Fusion Gene ORF analysis for ZNF599-SCN1B

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000329285	ENST00000596348	ZNF599	chr19	35258221	-	SCN1B	chr19	35523432	+
5CDS-3UTR	ENST00000587354	ENST00000596348	ZNF599	chr19	35258221	-	SCN1B	chr19	35523432	+
In-frame	ENST00000329285	ENST00000262631	ZNF599	chr19	35258221	-	SCN1B	chr19	35523432	+
In-frame	ENST00000329285	ENST00000415950	ZNF599	chr19	35258221	-	SCN1B	chr19	35523432	+
In-frame	ENST00000329285	ENST00000595652	ZNF599	chr19	35258221	-	SCN1B	chr19	35523432	+
In-frame	ENST00000587354	ENST00000262631	ZNF599	chr19	35258221	-	SCN1B	chr19	35523432	+
In-frame	ENST00000587354	ENST00000415950	ZNF599	chr19	35258221	-	SCN1B	chr19	35523432	+
In-frame	ENST00000587354	ENST00000595652	ZNF599	chr19	35258221	-	SCN1B	chr19	35523432	+
intron-3CDS	ENST00000588760	ENST00000262631	ZNF599	chr19	35258221	-	SCN1B	chr19	35523432	+
intron-3CDS	ENST00000588760	ENST00000415950	ZNF599	chr19	35258221	-	SCN1B	chr19	35523432	+
intron-3CDS	ENST00000588760	ENST00000595652	ZNF599	chr19	35258221	-	SCN1B	chr19	35523432	+
intron-3UTR	ENST00000588760	ENST00000596348	ZNF599	chr19	35258221	-	SCN1B	chr19	35523432	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000329285	ZNF599	chr19	35258221	-	ENST00000262631	SCN1B	chr19	35523432	+	1889	615	1834	620	404
ENST00000329285	ZNF599	chr19	35258221	-	ENST00000595652	SCN1B	chr19	35523432	+	1301	615	173	1018	281
ENST00000329285	ZNF599	chr19	35258221	-	ENST00000415950	SCN1B	chr19	35523432	+	1554	615	173	1381	402
ENST00000587354	ZNF599	chr19	35258221	-	ENST00000262631	SCN1B	chr19	35523432	+	1903	629	1848	634	404
ENST00000587354	ZNF599	chr19	35258221	-	ENST00000595652	SCN1B	chr19	35523432	+	1315	629	187	1032	281
ENST00000587354	ZNF599	chr19	35258221	-	ENST00000415950	SCN1B	chr19	35523432	+	1568	629	187	1395	402

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000329285	ENST00000262631	ZNF599	chr19	35258221	-	SCN1B	chr19	35523432	+	0.005706987	0.9942931
ENST00000329285	ENST00000595652	ZNF599	chr19	35258221	-	SCN1B	chr19	35523432	+	0.004040527	0.99595946
ENST00000329285	ENST00000415950	ZNF599	chr19	35258221	-	SCN1B	chr19	35523432	+	0.109218106	0.8907819
ENST00000587354	ENST00000262631	ZNF599	chr19	35258221	-	SCN1B	chr19	35523432	+	0.005602137	0.9943979
ENST00000587354	ENST00000595652	ZNF599	chr19	35258221	-	SCN1B	chr19	35523432	+	0.003905788	0.99609417
ENST00000587354	ENST00000415950	ZNF599	chr19	35258221	-	SCN1B	chr19	35523432	+	0.10383017	0.8961698

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Fusion Genomic Features for ZNF599-SCN1B

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ZNF599	chr19	35258220	-	SCN1B	chr19	35523431	+	3.49E-09	1
ZNF599	chr19	35258220	-	SCN1B	chr19	35523431	+	3.49E-09	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF599-SCN1B

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:35258221/chr19:35523432)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ZNF599

chr19:35258221

chr19:35523432

ENST00000329285

9_80

589.0

Domain

KRAB

Hgene

ZNF599

chr19:35258221

chr19:35523432

ENST00000587354

9_80

96.0

Domain

KRAB

Tgene

SCN1B

chr19:35258221

chr19:35523432

ENST00000262631

22_150

377.3333333333333

Domain

Note=Ig-like C2-type

Tgene

SCN1B

chr19:35258221

chr19:35523432

ENST00000415950

22_150

269.0

Domain

Note=Ig-like C2-type

Tgene

SCN1B

chr19:35258221

chr19:35523432

ENST00000262631

183_218

377.3333333333333

Topological domain

Cytoplasmic

Tgene

SCN1B

chr19:35258221

chr19:35523432

ENST00000262631

19_160

377.3333333333333

Topological domain

Extracellular

Tgene

SCN1B

chr19:35258221

chr19:35523432

ENST00000415950

183_218

269.0

Topological domain

Cytoplasmic

Tgene

SCN1B

chr19:35258221

chr19:35523432

ENST00000415950

19_160

269.0

Topological domain

Extracellular

Tgene

SCN1B

chr19:35258221

chr19:35523432

ENST00000262631

161_182

377.3333333333333

Transmembrane

Helical

Tgene

SCN1B

chr19:35258221

chr19:35523432

ENST00000415950

161_182

269.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ZNF599

chr19:35258221

chr19:35523432

ENST00000329285

199_221

589.0

Zinc finger

C2H2-type 1

Hgene

ZNF599

chr19:35258221

chr19:35523432

ENST00000329285

227_249

589.0

Zinc finger

C2H2-type 2

Hgene

ZNF599

chr19:35258221

chr19:35523432

ENST00000329285

255_277

589.0

Zinc finger

C2H2-type 3

Hgene

ZNF599

chr19:35258221

chr19:35523432

ENST00000329285

283_305

589.0

Zinc finger

C2H2-type 4

Hgene

ZNF599

chr19:35258221

chr19:35523432

ENST00000329285

311_333

589.0

Zinc finger

C2H2-type 5

Hgene

ZNF599

chr19:35258221

chr19:35523432

ENST00000329285

339_361

589.0

Zinc finger

C2H2-type 6

Hgene

ZNF599

chr19:35258221

chr19:35523432

ENST00000329285

367_389

589.0

Zinc finger

C2H2-type 7

Hgene

ZNF599

chr19:35258221

chr19:35523432

ENST00000329285

395_417

589.0

Zinc finger

C2H2-type 8

Hgene

ZNF599

chr19:35258221

chr19:35523432

ENST00000329285

423_445

589.0

Zinc finger

C2H2-type 9

Hgene

ZNF599

chr19:35258221

chr19:35523432

ENST00000329285

451_473

589.0

Zinc finger

C2H2-type 10

Hgene

ZNF599

chr19:35258221

chr19:35523432

ENST00000329285

479_501

589.0

Zinc finger

C2H2-type 11

Hgene

ZNF599

chr19:35258221

chr19:35523432

ENST00000329285

507_529

589.0

Zinc finger

C2H2-type 12

Hgene

ZNF599

chr19:35258221

chr19:35523432

ENST00000329285

535_557

589.0

Zinc finger

C2H2-type 13

Hgene

ZNF599

chr19:35258221

chr19:35523432

ENST00000329285

563_585

589.0

Zinc finger

C2H2-type 14

Hgene

ZNF599

chr19:35258221

chr19:35523432

ENST00000587354

199_221

96.0

Zinc finger

C2H2-type 1

Hgene

ZNF599

chr19:35258221

chr19:35523432

ENST00000587354

227_249

96.0

Zinc finger

C2H2-type 2

Hgene

ZNF599

chr19:35258221

chr19:35523432

ENST00000587354

255_277

96.0

Zinc finger

C2H2-type 3

Hgene

ZNF599

chr19:35258221

chr19:35523432

ENST00000587354

283_305

96.0

Zinc finger

C2H2-type 4

Hgene

ZNF599

chr19:35258221

chr19:35523432

ENST00000587354

311_333

96.0

Zinc finger

C2H2-type 5

Hgene

ZNF599

chr19:35258221

chr19:35523432

ENST00000587354

339_361

96.0

Zinc finger

C2H2-type 6

Hgene

ZNF599

chr19:35258221

chr19:35523432

ENST00000587354

367_389

96.0

Zinc finger

C2H2-type 7

Hgene

ZNF599

chr19:35258221

chr19:35523432

ENST00000587354

395_417

96.0

Zinc finger

C2H2-type 8

Hgene

ZNF599

chr19:35258221

chr19:35523432

ENST00000587354

423_445

96.0

Zinc finger

C2H2-type 9

Hgene

ZNF599

chr19:35258221

chr19:35523432

ENST00000587354

451_473

96.0

Zinc finger

C2H2-type 10

Hgene

ZNF599

chr19:35258221

chr19:35523432

ENST00000587354

479_501

96.0

Zinc finger

C2H2-type 11

Hgene

ZNF599

chr19:35258221

chr19:35523432

ENST00000587354

507_529

96.0

Zinc finger

C2H2-type 12

Hgene

ZNF599

chr19:35258221

chr19:35523432

ENST00000587354

535_557

96.0

Zinc finger

C2H2-type 13

Hgene

ZNF599

chr19:35258221

chr19:35523432

ENST00000587354

563_585

96.0

Zinc finger

C2H2-type 14

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Fusion Gene Sequence for ZNF599-SCN1B

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>102514_102514_1_ZNF599-SCN1B_ZNF599_chr19_35258221_ENST00000329285_SCN1B_chr19_35523432_ENST00000262631_length(transcript)=1889nt_BP=615nt
CGGCGTCCAGTCTTCGTCCGCCGTTAGGTTGCGGCTGCTGTGGTTGCCAACGCTACACTGGGTAGAACGCCAGACAGGGGCCACTTTTCG
AGACCGAGTAGAGACGGACAGTGAGGAGGATAGGACCCACTTACACGCTTTTATGTCAGCCGCGATCCCACCCCCACAAGCGTCTGCAAA
ACCCTTCCTGGGGCCTTGGCGACAGCCCTGTGTCCTCACGGCGCGCAGAGGCGGCGCCGCGAACCTTGTGTGCATTTTACACGACGGCGG
GGACTGAGGTCCCTCGCAGCCCAGAGCCGGAGCCCGGGGTCGGCCGAGCCCGCAGGACCGGCTTCCTCGCCGACTCTCACGGCCTCACCC
AGCCCCCTGGGCCCATGGCGGCGCCGGCGTTGGCATTAGTATCATTTGAAGACGTGGTTGTGACCTTCACTGGAGAGGAATGGGGGCACC
TGGACCTGGCCCAGAGGACCCTGTACCAGGAGGTGATGCTGGAGACCTGCAGGCTCCTGGTCTCACTGGGGCATCCTGTTCCCAAACCAG
AGCTGATCTATCTACTGGAACATGGACAGGAACTGTGGACAGTGAAGAGAGGCCTCTCCCAAAGCACCTGCGCAGTGTCCTCAGCCTGCG
GGGGCTGCGTGGAGGTGGACTCGGAGACCGAGGCCGTGTATGGGATGACCTTCAAAATTCTTTGCATCTCCTGCAAGCGCCGCAGCGAGA
CCAACGCTGAGACCTTCACCGAGTGGACCTTCCGCCAGAAGGGCACTGAGGAGTTTGTCAAGATCCTGCGCTATGAGAATGAGGTGTTGC
AGCTGGAGGAGGATGAGCGCTTCGAGGGCCGCGTGGTGTGGAATGGCAGCCGGGGCACCAAAGACCTGCAGGATCTGTCTATCTTCATCA
CCAATGTCACCTACAACCACTCGGGCGACTACGAGTGCCACGTCTACCGCCTGCTCTTCTTCGAAAACTACGAGCACAACACCAGCGTCG
TCAAGAAGATCCACATTGAGGTAGTGGACAAAGCCAACAGAGACATGGCATCCATCGTGTCTGAGATCATGATGTATGTGCTCATTGTGG
TGTTGACCATATGGCTCGTGGCAGAGATGATTTACTGCTACAAGAAGATCGCTGCCGCCACGGAGACTGCTGCACAGGAGAATGCCTCGG
AATACCTGGCCATCACCTCTGAAAGCAAAGAGAACTGCACGGGCGTCCAGGTGGCCGAATAGCCCTGGCCCTGGGCCCCGCCTCAAGGAA
GAGCCAGCCGTAATGGGGACTCTCCAGGCACCGCCTGCCCCCAGCGTGGGGGTGGCCACTCCTGGGCCCCAGAAAGCCTCAGAGTCCTGC
CGACGGAGCCACTGGGGTGGGAGGGGGCAGGGGGCTTGGCTCGCACCCCCACTTTCGCCTCCTCCAGCTCCTGCCCCGCCGGCCGCGCAC
CGCCATGCATGATGGGTAAAGCAATACTGCCGCTGCCCCCACCCTGCTTCTGCTGCCTGTTTGGGGAGGGGGGCGGTGAGGTGGGGGCAG
CGGCCCCGCACCCCTCCTCCTTGCTGATTTGCACACATTGGCCGCTTCAGACACGCACTTCTGGGGCCAGCCCCTCCCCGCCTCCTCCCT
GCCTGGCGGCAGGGGTCGCGATGATGGGCTGGAGCAGTTTGGGGCAGGGGGTTCTGGGACCCACTCCGACTCCCCCTCCCCGGCATCATT
TCCCCTCCCGCTTCCTCCGGCTGGACCTGGGGTCCCCCCTCCCTGTAATGCACTCCTGCCCCGGCCCAACCTCGCCCTCTCTCACCAGCC

>102514_102514_1_ZNF599-SCN1B_ZNF599_chr19_35258221_ENST00000329285_SCN1B_chr19_35523432_ENST00000262631_length(amino acids)=404AA_BP=1
MNGPLSRWPQFKAGERGRGWAGAGVHYREGGPQVQPEEAGGEMMPGRGSRSGSQNPLPQTAPAHHRDPCRQAGRRRGGAGPRSACLKRPM
CANQQGGGVRGRCPHLTAPLPKQAAEAGWGQRQYCFTHHAWRCAAGGAGAGGGESGGASQAPCPLPPQWLRRQDSEAFWGPGVATPTLGA
GGAWRVPITAGSSLRRGPGPGLFGHLDARAVLFAFRGDGQVFRGILLCSSLRGGSDLLVAVNHLCHEPYGQHHNEHIHHDLRHDGCHVSV
GFVHYLNVDLLDDAGVVLVVFEEEQAVDVALVVARVVVGDIGDEDRQILQVFGAPAAIPHHAALEALILLQLQHLILIAQDLDKLLSALL

--------------------------------------------------------------
>102514_102514_2_ZNF599-SCN1B_ZNF599_chr19_35258221_ENST00000329285_SCN1B_chr19_35523432_ENST00000415950_length(transcript)=1554nt_BP=615nt
CGGCGTCCAGTCTTCGTCCGCCGTTAGGTTGCGGCTGCTGTGGTTGCCAACGCTACACTGGGTAGAACGCCAGACAGGGGCCACTTTTCG
AGACCGAGTAGAGACGGACAGTGAGGAGGATAGGACCCACTTACACGCTTTTATGTCAGCCGCGATCCCACCCCCACAAGCGTCTGCAAA
ACCCTTCCTGGGGCCTTGGCGACAGCCCTGTGTCCTCACGGCGCGCAGAGGCGGCGCCGCGAACCTTGTGTGCATTTTACACGACGGCGG
GGACTGAGGTCCCTCGCAGCCCAGAGCCGGAGCCCGGGGTCGGCCGAGCCCGCAGGACCGGCTTCCTCGCCGACTCTCACGGCCTCACCC
AGCCCCCTGGGCCCATGGCGGCGCCGGCGTTGGCATTAGTATCATTTGAAGACGTGGTTGTGACCTTCACTGGAGAGGAATGGGGGCACC
TGGACCTGGCCCAGAGGACCCTGTACCAGGAGGTGATGCTGGAGACCTGCAGGCTCCTGGTCTCACTGGGGCATCCTGTTCCCAAACCAG
AGCTGATCTATCTACTGGAACATGGACAGGAACTGTGGACAGTGAAGAGAGGCCTCTCCCAAAGCACCTGCGCAGTGTCCTCAGCCTGCG
GGGGCTGCGTGGAGGTGGACTCGGAGACCGAGGCCGTGTATGGGATGACCTTCAAAATTCTTTGCATCTCCTGCAAGCGCCGCAGCGAGA
CCAACGCTGAGACCTTCACCGAGTGGACCTTCCGCCAGAAGGGCACTGAGGAGTTTGTCAAGATCCTGCGCTATGAGAATGAGGTGTTGC
AGCTGGAGGAGGATGAGCGCTTCGAGGGCCGCGTGGTGTGGAATGGCAGCCGGGGCACCAAAGACCTGCAGGATCTGTCTATCTTCATCA
CCAATGTCACCTACAACCACTCGGGCGACTACGAGTGCCACGTCTACCGCCTGCTCTTCTTCGAAAACTACGAGCACAACACCAGCGTCG
TCAAGAAGATCCACATTGAGGTAGTGGACAAAGGTGAGTCGGGTGCTGCCTGCCCCTTTACCGTCACCCACCGGAGAGCCAGATGGAGGG
ACAGATGGCAGGCAGTGGACAGGACAGGCTGGCTCTGTGCCTGGCCAGCCAACCGCCCACAGCAGCGGGCTGAGGGGGAGGGGAGCAGCC
CCTCCTGCCCACTCCAGCTCTGGCCTCTGTTTCTCTCCAGCCCACGGAGAGGTCAAAGCATGCCTGTCCCCCACAGACGCTCCGGGTACA
GAACCCAGCTCTGTCACCTGTGCTGTATGACCTCTGGCAGGTGCCTTCTGTCTCTGAGCCAAAGGGTTGTCCTGGGCTTGCCCGGGATAA
TAATCCGATGTGTTTCTCGGGGTGTGGTTTGAGCCATTCTTCCATCATGGGGTTCATGAGGATTGAGCAGCTGCAGGCACACGCCTGGCT
TCCAGCAGAGCCTTGCAGGTGGTGGCGAGGGTGGCGGTTCTTACTGTTCGAGTAGCTCAGCCCTGCTGCCCTCTGTGGTGATGAGGCAAG

>102514_102514_2_ZNF599-SCN1B_ZNF599_chr19_35258221_ENST00000329285_SCN1B_chr19_35523432_ENST00000415950_length(amino acids)=402AA_BP=147
MQNPSWGLGDSPVSSRRAEAAPRTLCAFYTTAGTEVPRSPEPEPGVGRARRTGFLADSHGLTQPPGPMAAPALALVSFEDVVVTFTGEEW
GHLDLAQRTLYQEVMLETCRLLVSLGHPVPKPELIYLLEHGQELWTVKRGLSQSTCAVSSACGGCVEVDSETEAVYGMTFKILCISCKRR
SETNAETFTEWTFRQKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYECHVYRLLFFENYEHNT
SVVKKIHIEVVDKGESGAACPFTVTHRRARWRDRWQAVDRTGWLCAWPANRPQQRAEGEGSSPSCPLQLWPLFLSSPRRGQSMPVPHRRS

--------------------------------------------------------------
>102514_102514_3_ZNF599-SCN1B_ZNF599_chr19_35258221_ENST00000329285_SCN1B_chr19_35523432_ENST00000595652_length(transcript)=1301nt_BP=615nt
CGGCGTCCAGTCTTCGTCCGCCGTTAGGTTGCGGCTGCTGTGGTTGCCAACGCTACACTGGGTAGAACGCCAGACAGGGGCCACTTTTCG
AGACCGAGTAGAGACGGACAGTGAGGAGGATAGGACCCACTTACACGCTTTTATGTCAGCCGCGATCCCACCCCCACAAGCGTCTGCAAA
ACCCTTCCTGGGGCCTTGGCGACAGCCCTGTGTCCTCACGGCGCGCAGAGGCGGCGCCGCGAACCTTGTGTGCATTTTACACGACGGCGG
GGACTGAGGTCCCTCGCAGCCCAGAGCCGGAGCCCGGGGTCGGCCGAGCCCGCAGGACCGGCTTCCTCGCCGACTCTCACGGCCTCACCC
AGCCCCCTGGGCCCATGGCGGCGCCGGCGTTGGCATTAGTATCATTTGAAGACGTGGTTGTGACCTTCACTGGAGAGGAATGGGGGCACC
TGGACCTGGCCCAGAGGACCCTGTACCAGGAGGTGATGCTGGAGACCTGCAGGCTCCTGGTCTCACTGGGGCATCCTGTTCCCAAACCAG
AGCTGATCTATCTACTGGAACATGGACAGGAACTGTGGACAGTGAAGAGAGGCCTCTCCCAAAGCACCTGCGCAGTGTCCTCAGCCTGCG
GGGGCTGCGTGGAGGTGGACTCGGAGACCGAGGCCGTGTATGGGATGACCTTCAAAATTCTTTGCATCTCCTGCAAGCGCCGCAGCGAGA
CCAACGCTGAGACCTTCACCGAGTGGACCTTCCGCCAGAAGGGCACTGAGGAGTTTGTCAAGAAGATCCACATTGAGGTAGTGGACAAAG
CCAACAGAGACATGGCATCCATCGTGTCTGAGATCATGATGTATGTGCTCATTGTGGTGTTGACCATATGGCTCGTGGCAGAGATGATTT
ACTGCTACAAGAAGATCGCTGCCGCCACGGAGACTGCTGCACAGGAGAATGCCTCGGAATACCTGGCCATCACCTCTGAAAGCAAAGAGA
ACTGCACGGGCGTCCAGGTGGCCGAATAGCCCTGGCCCTGGGCCCCGCCTCAAGGAAGAGCCAGCCGTAATGGGGACTCTCCAGGCACCG
CCTGCCCCCAGCGTGGGGGTGGCCACTCCTGGGCCCCAGAAAGCCTCAGAGTCCTGCCGACGGAGCCACTGGGGTGGGAGGGGGCAGGGG
GCTTGGCTCGCACCCCCACTTTCGCCTCCTCCAGCTCCTGCCCCGCCGGCCGCGCACCGCCATGCATGATGGGTAAAGCAATACTGCCGC

>102514_102514_3_ZNF599-SCN1B_ZNF599_chr19_35258221_ENST00000329285_SCN1B_chr19_35523432_ENST00000595652_length(amino acids)=281AA_BP=147
MQNPSWGLGDSPVSSRRAEAAPRTLCAFYTTAGTEVPRSPEPEPGVGRARRTGFLADSHGLTQPPGPMAAPALALVSFEDVVVTFTGEEW
GHLDLAQRTLYQEVMLETCRLLVSLGHPVPKPELIYLLEHGQELWTVKRGLSQSTCAVSSACGGCVEVDSETEAVYGMTFKILCISCKRR
SETNAETFTEWTFRQKGTEEFVKKIHIEVVDKANRDMASIVSEIMMYVLIVVLTIWLVAEMIYCYKKIAAATETAAQENASEYLAITSES

--------------------------------------------------------------
>102514_102514_4_ZNF599-SCN1B_ZNF599_chr19_35258221_ENST00000587354_SCN1B_chr19_35523432_ENST00000262631_length(transcript)=1903nt_BP=629nt
GTGGGCGGGACTTCCGGCGTCCAGTCTTCGTCCGCCGTTAGGTTGCGGCTGCTGTGGTTGCCAACGCTACACTGGGTAGAACGCCAGACA
GGGGCCACTTTTCGAGACCGAGTAGAGACGGACAGTGAGGAGGATAGGACCCACTTACACGCTTTTATGTCAGCCGCGATCCCACCCCCA
CAAGCGTCTGCAAAACCCTTCCTGGGGCCTTGGCGACAGCCCTGTGTCCTCACGGCGCGCAGAGGCGGCGCCGCGAACCTTGTGTGCATT
TTACACGACGGCGGGGACTGAGGTCCCTCGCAGCCCAGAGCCGGAGCCCGGGGTCGGCCGAGCCCGCAGGACCGGCTTCCTCGCCGACTC
TCACGGCCTCACCCAGCCCCCTGGGCCCATGGCGGCGCCGGCGTTGGCATTAGTATCATTTGAAGACGTGGTTGTGACCTTCACTGGAGA
GGAATGGGGGCACCTGGACCTGGCCCAGAGGACCCTGTACCAGGAGGTGATGCTGGAGACCTGCAGGCTCCTGGTCTCACTGGGGCATCC
TGTTCCCAAACCAGAGCTGATCTATCTACTGGAACATGGACAGGAACTGTGGACAGTGAAGAGAGGCCTCTCCCAAAGCACCTGCGCAGT
GTCCTCAGCCTGCGGGGGCTGCGTGGAGGTGGACTCGGAGACCGAGGCCGTGTATGGGATGACCTTCAAAATTCTTTGCATCTCCTGCAA
GCGCCGCAGCGAGACCAACGCTGAGACCTTCACCGAGTGGACCTTCCGCCAGAAGGGCACTGAGGAGTTTGTCAAGATCCTGCGCTATGA
GAATGAGGTGTTGCAGCTGGAGGAGGATGAGCGCTTCGAGGGCCGCGTGGTGTGGAATGGCAGCCGGGGCACCAAAGACCTGCAGGATCT
GTCTATCTTCATCACCAATGTCACCTACAACCACTCGGGCGACTACGAGTGCCACGTCTACCGCCTGCTCTTCTTCGAAAACTACGAGCA
CAACACCAGCGTCGTCAAGAAGATCCACATTGAGGTAGTGGACAAAGCCAACAGAGACATGGCATCCATCGTGTCTGAGATCATGATGTA
TGTGCTCATTGTGGTGTTGACCATATGGCTCGTGGCAGAGATGATTTACTGCTACAAGAAGATCGCTGCCGCCACGGAGACTGCTGCACA
GGAGAATGCCTCGGAATACCTGGCCATCACCTCTGAAAGCAAAGAGAACTGCACGGGCGTCCAGGTGGCCGAATAGCCCTGGCCCTGGGC
CCCGCCTCAAGGAAGAGCCAGCCGTAATGGGGACTCTCCAGGCACCGCCTGCCCCCAGCGTGGGGGTGGCCACTCCTGGGCCCCAGAAAG
CCTCAGAGTCCTGCCGACGGAGCCACTGGGGTGGGAGGGGGCAGGGGGCTTGGCTCGCACCCCCACTTTCGCCTCCTCCAGCTCCTGCCC
CGCCGGCCGCGCACCGCCATGCATGATGGGTAAAGCAATACTGCCGCTGCCCCCACCCTGCTTCTGCTGCCTGTTTGGGGAGGGGGGCGG
TGAGGTGGGGGCAGCGGCCCCGCACCCCTCCTCCTTGCTGATTTGCACACATTGGCCGCTTCAGACACGCACTTCTGGGGCCAGCCCCTC
CCCGCCTCCTCCCTGCCTGGCGGCAGGGGTCGCGATGATGGGCTGGAGCAGTTTGGGGCAGGGGGTTCTGGGACCCACTCCGACTCCCCC
TCCCCGGCATCATTTCCCCTCCCGCTTCCTCCGGCTGGACCTGGGGTCCCCCCTCCCTGTAATGCACTCCTGCCCCGGCCCAACCTCGCC
CTCTCTCACCAGCCTTGAACTGTGGCCACCTAGAAAGGGGCCCATTCAGCCTCGTCTCTTTACAGAAGTAGTTTTGTTCATGAAATAAAG

>102514_102514_4_ZNF599-SCN1B_ZNF599_chr19_35258221_ENST00000587354_SCN1B_chr19_35523432_ENST00000262631_length(amino acids)=404AA_BP=1
MNGPLSRWPQFKAGERGRGWAGAGVHYREGGPQVQPEEAGGEMMPGRGSRSGSQNPLPQTAPAHHRDPCRQAGRRRGGAGPRSACLKRPM
CANQQGGGVRGRCPHLTAPLPKQAAEAGWGQRQYCFTHHAWRCAAGGAGAGGGESGGASQAPCPLPPQWLRRQDSEAFWGPGVATPTLGA
GGAWRVPITAGSSLRRGPGPGLFGHLDARAVLFAFRGDGQVFRGILLCSSLRGGSDLLVAVNHLCHEPYGQHHNEHIHHDLRHDGCHVSV
GFVHYLNVDLLDDAGVVLVVFEEEQAVDVALVVARVVVGDIGDEDRQILQVFGAPAAIPHHAALEALILLQLQHLILIAQDLDKLLSALL

--------------------------------------------------------------
>102514_102514_5_ZNF599-SCN1B_ZNF599_chr19_35258221_ENST00000587354_SCN1B_chr19_35523432_ENST00000415950_length(transcript)=1568nt_BP=629nt
GTGGGCGGGACTTCCGGCGTCCAGTCTTCGTCCGCCGTTAGGTTGCGGCTGCTGTGGTTGCCAACGCTACACTGGGTAGAACGCCAGACA
GGGGCCACTTTTCGAGACCGAGTAGAGACGGACAGTGAGGAGGATAGGACCCACTTACACGCTTTTATGTCAGCCGCGATCCCACCCCCA
CAAGCGTCTGCAAAACCCTTCCTGGGGCCTTGGCGACAGCCCTGTGTCCTCACGGCGCGCAGAGGCGGCGCCGCGAACCTTGTGTGCATT
TTACACGACGGCGGGGACTGAGGTCCCTCGCAGCCCAGAGCCGGAGCCCGGGGTCGGCCGAGCCCGCAGGACCGGCTTCCTCGCCGACTC
TCACGGCCTCACCCAGCCCCCTGGGCCCATGGCGGCGCCGGCGTTGGCATTAGTATCATTTGAAGACGTGGTTGTGACCTTCACTGGAGA
GGAATGGGGGCACCTGGACCTGGCCCAGAGGACCCTGTACCAGGAGGTGATGCTGGAGACCTGCAGGCTCCTGGTCTCACTGGGGCATCC
TGTTCCCAAACCAGAGCTGATCTATCTACTGGAACATGGACAGGAACTGTGGACAGTGAAGAGAGGCCTCTCCCAAAGCACCTGCGCAGT
GTCCTCAGCCTGCGGGGGCTGCGTGGAGGTGGACTCGGAGACCGAGGCCGTGTATGGGATGACCTTCAAAATTCTTTGCATCTCCTGCAA
GCGCCGCAGCGAGACCAACGCTGAGACCTTCACCGAGTGGACCTTCCGCCAGAAGGGCACTGAGGAGTTTGTCAAGATCCTGCGCTATGA
GAATGAGGTGTTGCAGCTGGAGGAGGATGAGCGCTTCGAGGGCCGCGTGGTGTGGAATGGCAGCCGGGGCACCAAAGACCTGCAGGATCT
GTCTATCTTCATCACCAATGTCACCTACAACCACTCGGGCGACTACGAGTGCCACGTCTACCGCCTGCTCTTCTTCGAAAACTACGAGCA
CAACACCAGCGTCGTCAAGAAGATCCACATTGAGGTAGTGGACAAAGGTGAGTCGGGTGCTGCCTGCCCCTTTACCGTCACCCACCGGAG
AGCCAGATGGAGGGACAGATGGCAGGCAGTGGACAGGACAGGCTGGCTCTGTGCCTGGCCAGCCAACCGCCCACAGCAGCGGGCTGAGGG
GGAGGGGAGCAGCCCCTCCTGCCCACTCCAGCTCTGGCCTCTGTTTCTCTCCAGCCCACGGAGAGGTCAAAGCATGCCTGTCCCCCACAG
ACGCTCCGGGTACAGAACCCAGCTCTGTCACCTGTGCTGTATGACCTCTGGCAGGTGCCTTCTGTCTCTGAGCCAAAGGGTTGTCCTGGG
CTTGCCCGGGATAATAATCCGATGTGTTTCTCGGGGTGTGGTTTGAGCCATTCTTCCATCATGGGGTTCATGAGGATTGAGCAGCTGCAG
GCACACGCCTGGCTTCCAGCAGAGCCTTGCAGGTGGTGGCGAGGGTGGCGGTTCTTACTGTTCGAGTAGCTCAGCCCTGCTGCCCTCTGT

>102514_102514_5_ZNF599-SCN1B_ZNF599_chr19_35258221_ENST00000587354_SCN1B_chr19_35523432_ENST00000415950_length(amino acids)=402AA_BP=147
MQNPSWGLGDSPVSSRRAEAAPRTLCAFYTTAGTEVPRSPEPEPGVGRARRTGFLADSHGLTQPPGPMAAPALALVSFEDVVVTFTGEEW
GHLDLAQRTLYQEVMLETCRLLVSLGHPVPKPELIYLLEHGQELWTVKRGLSQSTCAVSSACGGCVEVDSETEAVYGMTFKILCISCKRR
SETNAETFTEWTFRQKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYECHVYRLLFFENYEHNT
SVVKKIHIEVVDKGESGAACPFTVTHRRARWRDRWQAVDRTGWLCAWPANRPQQRAEGEGSSPSCPLQLWPLFLSSPRRGQSMPVPHRRS

--------------------------------------------------------------
>102514_102514_6_ZNF599-SCN1B_ZNF599_chr19_35258221_ENST00000587354_SCN1B_chr19_35523432_ENST00000595652_length(transcript)=1315nt_BP=629nt
GTGGGCGGGACTTCCGGCGTCCAGTCTTCGTCCGCCGTTAGGTTGCGGCTGCTGTGGTTGCCAACGCTACACTGGGTAGAACGCCAGACA
GGGGCCACTTTTCGAGACCGAGTAGAGACGGACAGTGAGGAGGATAGGACCCACTTACACGCTTTTATGTCAGCCGCGATCCCACCCCCA
CAAGCGTCTGCAAAACCCTTCCTGGGGCCTTGGCGACAGCCCTGTGTCCTCACGGCGCGCAGAGGCGGCGCCGCGAACCTTGTGTGCATT
TTACACGACGGCGGGGACTGAGGTCCCTCGCAGCCCAGAGCCGGAGCCCGGGGTCGGCCGAGCCCGCAGGACCGGCTTCCTCGCCGACTC
TCACGGCCTCACCCAGCCCCCTGGGCCCATGGCGGCGCCGGCGTTGGCATTAGTATCATTTGAAGACGTGGTTGTGACCTTCACTGGAGA
GGAATGGGGGCACCTGGACCTGGCCCAGAGGACCCTGTACCAGGAGGTGATGCTGGAGACCTGCAGGCTCCTGGTCTCACTGGGGCATCC
TGTTCCCAAACCAGAGCTGATCTATCTACTGGAACATGGACAGGAACTGTGGACAGTGAAGAGAGGCCTCTCCCAAAGCACCTGCGCAGT
GTCCTCAGCCTGCGGGGGCTGCGTGGAGGTGGACTCGGAGACCGAGGCCGTGTATGGGATGACCTTCAAAATTCTTTGCATCTCCTGCAA
GCGCCGCAGCGAGACCAACGCTGAGACCTTCACCGAGTGGACCTTCCGCCAGAAGGGCACTGAGGAGTTTGTCAAGAAGATCCACATTGA
GGTAGTGGACAAAGCCAACAGAGACATGGCATCCATCGTGTCTGAGATCATGATGTATGTGCTCATTGTGGTGTTGACCATATGGCTCGT
GGCAGAGATGATTTACTGCTACAAGAAGATCGCTGCCGCCACGGAGACTGCTGCACAGGAGAATGCCTCGGAATACCTGGCCATCACCTC
TGAAAGCAAAGAGAACTGCACGGGCGTCCAGGTGGCCGAATAGCCCTGGCCCTGGGCCCCGCCTCAAGGAAGAGCCAGCCGTAATGGGGA
CTCTCCAGGCACCGCCTGCCCCCAGCGTGGGGGTGGCCACTCCTGGGCCCCAGAAAGCCTCAGAGTCCTGCCGACGGAGCCACTGGGGTG
GGAGGGGGCAGGGGGCTTGGCTCGCACCCCCACTTTCGCCTCCTCCAGCTCCTGCCCCGCCGGCCGCGCACCGCCATGCATGATGGGTAA

>102514_102514_6_ZNF599-SCN1B_ZNF599_chr19_35258221_ENST00000587354_SCN1B_chr19_35523432_ENST00000595652_length(amino acids)=281AA_BP=147
MQNPSWGLGDSPVSSRRAEAAPRTLCAFYTTAGTEVPRSPEPEPGVGRARRTGFLADSHGLTQPPGPMAAPALALVSFEDVVVTFTGEEW
GHLDLAQRTLYQEVMLETCRLLVSLGHPVPKPELIYLLEHGQELWTVKRGLSQSTCAVSSACGGCVEVDSETEAVYGMTFKILCISCKRR
SETNAETFTEWTFRQKGTEEFVKKIHIEVVDKANRDMASIVSEIMMYVLIVVLTIWLVAEMIYCYKKIAAATETAAQENASEYLAITSES

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ZNF599-SCN1B

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ZNF599-SCN1B

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ZNF599-SCN1B

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source