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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Fusion gene:ZNF615-SLC17A7 (FusionGDB2 ID:102566)

Fusion Gene Summary for ZNF615-SLC17A7

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF615-SLC17A7
Fusion gene ID: 102566
HgeneTgene
Gene symbol

ZNF615

SLC17A7

Gene ID

284370

57030

Gene namezinc finger protein 615solute carrier family 17 member 7
Synonyms-BNPI|VGLUT1
Cytomap

19q13.41

19q13.33

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 615vesicular glutamate transporter 1brain-specific Na(+)-dependent inorganic phosphate cotransporterbrain-specific Na-dependent inorganic phosphate cotransportersolute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7solute
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000376716, ENST00000594083, 
ENST00000595114, ENST00000597747, 
ENST00000598071, ENST00000391795, 
ENST00000602063, 		ENST00000221485, 
ENST00000543531, ENST00000600601, 
Fusion gene scores* DoF score3 X 2 X 3=182 X 2 X 2=8
# samples 32
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/8*10)=1.32192809488736
Context

PubMed: ZNF615 [Title/Abstract] AND SLC17A7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF615(52511394)-SLC17A7(49936217), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ZNF615 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SLC17A7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-ER-A195-06AZNF615chr19

52511394

-SLC17A7chr19

49936217

-


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Fusion Gene ORF analysis for ZNF615-SLC17A7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000376716ENST00000221485ZNF615chr19

52511394

-SLC17A7chr19

49936217

-
5UTR-3CDSENST00000376716ENST00000543531ZNF615chr19

52511394

-SLC17A7chr19

49936217

-
5UTR-3CDSENST00000376716ENST00000600601ZNF615chr19

52511394

-SLC17A7chr19

49936217

-
5UTR-3CDSENST00000594083ENST00000221485ZNF615chr19

52511394

-SLC17A7chr19

49936217

-
5UTR-3CDSENST00000594083ENST00000543531ZNF615chr19

52511394

-SLC17A7chr19

49936217

-
5UTR-3CDSENST00000594083ENST00000600601ZNF615chr19

52511394

-SLC17A7chr19

49936217

-
5UTR-3CDSENST00000595114ENST00000221485ZNF615chr19

52511394

-SLC17A7chr19

49936217

-
5UTR-3CDSENST00000595114ENST00000543531ZNF615chr19

52511394

-SLC17A7chr19

49936217

-
5UTR-3CDSENST00000595114ENST00000600601ZNF615chr19

52511394

-SLC17A7chr19

49936217

-
5UTR-3CDSENST00000597747ENST00000221485ZNF615chr19

52511394

-SLC17A7chr19

49936217

-
5UTR-3CDSENST00000597747ENST00000543531ZNF615chr19

52511394

-SLC17A7chr19

49936217

-
5UTR-3CDSENST00000597747ENST00000600601ZNF615chr19

52511394

-SLC17A7chr19

49936217

-
5UTR-3CDSENST00000598071ENST00000221485ZNF615chr19

52511394

-SLC17A7chr19

49936217

-
5UTR-3CDSENST00000598071ENST00000543531ZNF615chr19

52511394

-SLC17A7chr19

49936217

-
5UTR-3CDSENST00000598071ENST00000600601ZNF615chr19

52511394

-SLC17A7chr19

49936217

-
In-frameENST00000391795ENST00000221485ZNF615chr19

52511394

-SLC17A7chr19

49936217

-
In-frameENST00000391795ENST00000543531ZNF615chr19

52511394

-SLC17A7chr19

49936217

-
In-frameENST00000391795ENST00000600601ZNF615chr19

52511394

-SLC17A7chr19

49936217

-
intron-3CDSENST00000602063ENST00000221485ZNF615chr19

52511394

-SLC17A7chr19

49936217

-
intron-3CDSENST00000602063ENST00000543531ZNF615chr19

52511394

-SLC17A7chr19

49936217

-
intron-3CDSENST00000602063ENST00000600601ZNF615chr19

52511394

-SLC17A7chr19

49936217

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000391795ZNF615chr1952511394-ENST00000221485SLC17A7chr1949936217-20249060905281
ENST00000391795ZNF615chr1952511394-ENST00000543531SLC17A7chr1949936217-14399060905281
ENST00000391795ZNF615chr1952511394-ENST00000600601SLC17A7chr1949936217-14399060905281

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000391795ENST00000221485ZNF615chr1952511394-SLC17A7chr1949936217-0.0186058520.9813942
ENST00000391795ENST00000543531ZNF615chr1952511394-SLC17A7chr1949936217-0.0174497350.9825502
ENST00000391795ENST00000600601ZNF615chr1952511394-SLC17A7chr1949936217-0.0174497350.9825502

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Fusion Genomic Features for ZNF615-SLC17A7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF615-SLC17A7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:52511394/chr19:49936217)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSLC17A7chr19:52511394chr19:49936217ENST00000221485612530_556289561.0Compositional biasNote=Pro-rich
TgeneSLC17A7chr19:52511394chr19:49936217ENST00000221485612324_341289561.0Topological domainExtracellular
TgeneSLC17A7chr19:52511394chr19:49936217ENST00000221485612363_378289561.0Topological domainCytoplasmic
TgeneSLC17A7chr19:52511394chr19:49936217ENST00000221485612400_401289561.0Topological domainExtracellular
TgeneSLC17A7chr19:52511394chr19:49936217ENST00000221485612423_435289561.0Topological domainCytoplasmic
TgeneSLC17A7chr19:52511394chr19:49936217ENST00000221485612457_469289561.0Topological domainExtracellular
TgeneSLC17A7chr19:52511394chr19:49936217ENST00000221485612491_560289561.0Topological domainCytoplasmic
TgeneSLC17A7chr19:52511394chr19:49936217ENST00000221485612303_323289561.0TransmembraneHelical
TgeneSLC17A7chr19:52511394chr19:49936217ENST00000221485612342_362289561.0TransmembraneHelical
TgeneSLC17A7chr19:52511394chr19:49936217ENST00000221485612379_399289561.0TransmembraneHelical
TgeneSLC17A7chr19:52511394chr19:49936217ENST00000221485612402_422289561.0TransmembraneHelical
TgeneSLC17A7chr19:52511394chr19:49936217ENST00000221485612436_456289561.0TransmembraneHelical
TgeneSLC17A7chr19:52511394chr19:49936217ENST00000221485612470_490289561.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF615chr19:52511394chr19:49936217ENST00000376716-168_790732.0DomainKRAB
HgeneZNF615chr19:52511394chr19:49936217ENST00000594083-168_790743.0DomainKRAB
HgeneZNF615chr19:52511394chr19:49936217ENST00000598071-178_790743.0DomainKRAB
HgeneZNF615chr19:52511394chr19:49936217ENST00000602063-168_790732.0DomainKRAB
HgeneZNF615chr19:52511394chr19:49936217ENST00000376716-16204_2260732.0Zinc fingerC2H2-type 1
HgeneZNF615chr19:52511394chr19:49936217ENST00000376716-16232_2540732.0Zinc fingerC2H2-type 2
HgeneZNF615chr19:52511394chr19:49936217ENST00000376716-16260_2820732.0Zinc fingerC2H2-type 3
HgeneZNF615chr19:52511394chr19:49936217ENST00000376716-16288_3100732.0Zinc fingerC2H2-type 4
HgeneZNF615chr19:52511394chr19:49936217ENST00000376716-16316_3380732.0Zinc fingerC2H2-type 5
HgeneZNF615chr19:52511394chr19:49936217ENST00000376716-16344_3660732.0Zinc fingerC2H2-type 6
HgeneZNF615chr19:52511394chr19:49936217ENST00000376716-16372_3940732.0Zinc fingerC2H2-type 7
HgeneZNF615chr19:52511394chr19:49936217ENST00000376716-16400_4220732.0Zinc fingerC2H2-type 8
HgeneZNF615chr19:52511394chr19:49936217ENST00000376716-16428_4500732.0Zinc fingerC2H2-type 9
HgeneZNF615chr19:52511394chr19:49936217ENST00000376716-16456_4780732.0Zinc fingerC2H2-type 10
HgeneZNF615chr19:52511394chr19:49936217ENST00000376716-16484_5060732.0Zinc fingerC2H2-type 11
HgeneZNF615chr19:52511394chr19:49936217ENST00000376716-16512_5340732.0Zinc fingerC2H2-type 12
HgeneZNF615chr19:52511394chr19:49936217ENST00000376716-16540_5620732.0Zinc fingerC2H2-type 13
HgeneZNF615chr19:52511394chr19:49936217ENST00000376716-16568_5900732.0Zinc fingerC2H2-type 14
HgeneZNF615chr19:52511394chr19:49936217ENST00000376716-16596_6180732.0Zinc fingerC2H2-type 15
HgeneZNF615chr19:52511394chr19:49936217ENST00000376716-16624_6460732.0Zinc fingerC2H2-type 16
HgeneZNF615chr19:52511394chr19:49936217ENST00000376716-16652_6740732.0Zinc fingerC2H2-type 17
HgeneZNF615chr19:52511394chr19:49936217ENST00000376716-16680_7020732.0Zinc fingerC2H2-type 18
HgeneZNF615chr19:52511394chr19:49936217ENST00000376716-16708_7300732.0Zinc fingerC2H2-type 19
HgeneZNF615chr19:52511394chr19:49936217ENST00000594083-16204_2260743.0Zinc fingerC2H2-type 1
HgeneZNF615chr19:52511394chr19:49936217ENST00000594083-16232_2540743.0Zinc fingerC2H2-type 2
HgeneZNF615chr19:52511394chr19:49936217ENST00000594083-16260_2820743.0Zinc fingerC2H2-type 3
HgeneZNF615chr19:52511394chr19:49936217ENST00000594083-16288_3100743.0Zinc fingerC2H2-type 4
HgeneZNF615chr19:52511394chr19:49936217ENST00000594083-16316_3380743.0Zinc fingerC2H2-type 5
HgeneZNF615chr19:52511394chr19:49936217ENST00000594083-16344_3660743.0Zinc fingerC2H2-type 6
HgeneZNF615chr19:52511394chr19:49936217ENST00000594083-16372_3940743.0Zinc fingerC2H2-type 7
HgeneZNF615chr19:52511394chr19:49936217ENST00000594083-16400_4220743.0Zinc fingerC2H2-type 8
HgeneZNF615chr19:52511394chr19:49936217ENST00000594083-16428_4500743.0Zinc fingerC2H2-type 9
HgeneZNF615chr19:52511394chr19:49936217ENST00000594083-16456_4780743.0Zinc fingerC2H2-type 10
HgeneZNF615chr19:52511394chr19:49936217ENST00000594083-16484_5060743.0Zinc fingerC2H2-type 11
HgeneZNF615chr19:52511394chr19:49936217ENST00000594083-16512_5340743.0Zinc fingerC2H2-type 12
HgeneZNF615chr19:52511394chr19:49936217ENST00000594083-16540_5620743.0Zinc fingerC2H2-type 13
HgeneZNF615chr19:52511394chr19:49936217ENST00000594083-16568_5900743.0Zinc fingerC2H2-type 14
HgeneZNF615chr19:52511394chr19:49936217ENST00000594083-16596_6180743.0Zinc fingerC2H2-type 15
HgeneZNF615chr19:52511394chr19:49936217ENST00000594083-16624_6460743.0Zinc fingerC2H2-type 16
HgeneZNF615chr19:52511394chr19:49936217ENST00000594083-16652_6740743.0Zinc fingerC2H2-type 17
HgeneZNF615chr19:52511394chr19:49936217ENST00000594083-16680_7020743.0Zinc fingerC2H2-type 18
HgeneZNF615chr19:52511394chr19:49936217ENST00000594083-16708_7300743.0Zinc fingerC2H2-type 19
HgeneZNF615chr19:52511394chr19:49936217ENST00000598071-17204_2260743.0Zinc fingerC2H2-type 1
HgeneZNF615chr19:52511394chr19:49936217ENST00000598071-17232_2540743.0Zinc fingerC2H2-type 2
HgeneZNF615chr19:52511394chr19:49936217ENST00000598071-17260_2820743.0Zinc fingerC2H2-type 3
HgeneZNF615chr19:52511394chr19:49936217ENST00000598071-17288_3100743.0Zinc fingerC2H2-type 4
HgeneZNF615chr19:52511394chr19:49936217ENST00000598071-17316_3380743.0Zinc fingerC2H2-type 5
HgeneZNF615chr19:52511394chr19:49936217ENST00000598071-17344_3660743.0Zinc fingerC2H2-type 6
HgeneZNF615chr19:52511394chr19:49936217ENST00000598071-17372_3940743.0Zinc fingerC2H2-type 7
HgeneZNF615chr19:52511394chr19:49936217ENST00000598071-17400_4220743.0Zinc fingerC2H2-type 8
HgeneZNF615chr19:52511394chr19:49936217ENST00000598071-17428_4500743.0Zinc fingerC2H2-type 9
HgeneZNF615chr19:52511394chr19:49936217ENST00000598071-17456_4780743.0Zinc fingerC2H2-type 10
HgeneZNF615chr19:52511394chr19:49936217ENST00000598071-17484_5060743.0Zinc fingerC2H2-type 11
HgeneZNF615chr19:52511394chr19:49936217ENST00000598071-17512_5340743.0Zinc fingerC2H2-type 12
HgeneZNF615chr19:52511394chr19:49936217ENST00000598071-17540_5620743.0Zinc fingerC2H2-type 13
HgeneZNF615chr19:52511394chr19:49936217ENST00000598071-17568_5900743.0Zinc fingerC2H2-type 14
HgeneZNF615chr19:52511394chr19:49936217ENST00000598071-17596_6180743.0Zinc fingerC2H2-type 15
HgeneZNF615chr19:52511394chr19:49936217ENST00000598071-17624_6460743.0Zinc fingerC2H2-type 16
HgeneZNF615chr19:52511394chr19:49936217ENST00000598071-17652_6740743.0Zinc fingerC2H2-type 17
HgeneZNF615chr19:52511394chr19:49936217ENST00000598071-17680_7020743.0Zinc fingerC2H2-type 18
HgeneZNF615chr19:52511394chr19:49936217ENST00000598071-17708_7300743.0Zinc fingerC2H2-type 19
HgeneZNF615chr19:52511394chr19:49936217ENST00000602063-16204_2260732.0Zinc fingerC2H2-type 1
HgeneZNF615chr19:52511394chr19:49936217ENST00000602063-16232_2540732.0Zinc fingerC2H2-type 2
HgeneZNF615chr19:52511394chr19:49936217ENST00000602063-16260_2820732.0Zinc fingerC2H2-type 3
HgeneZNF615chr19:52511394chr19:49936217ENST00000602063-16288_3100732.0Zinc fingerC2H2-type 4
HgeneZNF615chr19:52511394chr19:49936217ENST00000602063-16316_3380732.0Zinc fingerC2H2-type 5
HgeneZNF615chr19:52511394chr19:49936217ENST00000602063-16344_3660732.0Zinc fingerC2H2-type 6
HgeneZNF615chr19:52511394chr19:49936217ENST00000602063-16372_3940732.0Zinc fingerC2H2-type 7
HgeneZNF615chr19:52511394chr19:49936217ENST00000602063-16400_4220732.0Zinc fingerC2H2-type 8
HgeneZNF615chr19:52511394chr19:49936217ENST00000602063-16428_4500732.0Zinc fingerC2H2-type 9
HgeneZNF615chr19:52511394chr19:49936217ENST00000602063-16456_4780732.0Zinc fingerC2H2-type 10
HgeneZNF615chr19:52511394chr19:49936217ENST00000602063-16484_5060732.0Zinc fingerC2H2-type 11
HgeneZNF615chr19:52511394chr19:49936217ENST00000602063-16512_5340732.0Zinc fingerC2H2-type 12
HgeneZNF615chr19:52511394chr19:49936217ENST00000602063-16540_5620732.0Zinc fingerC2H2-type 13
HgeneZNF615chr19:52511394chr19:49936217ENST00000602063-16568_5900732.0Zinc fingerC2H2-type 14
HgeneZNF615chr19:52511394chr19:49936217ENST00000602063-16596_6180732.0Zinc fingerC2H2-type 15
HgeneZNF615chr19:52511394chr19:49936217ENST00000602063-16624_6460732.0Zinc fingerC2H2-type 16
HgeneZNF615chr19:52511394chr19:49936217ENST00000602063-16652_6740732.0Zinc fingerC2H2-type 17
HgeneZNF615chr19:52511394chr19:49936217ENST00000602063-16680_7020732.0Zinc fingerC2H2-type 18
HgeneZNF615chr19:52511394chr19:49936217ENST00000602063-16708_7300732.0Zinc fingerC2H2-type 19
TgeneSLC17A7chr19:52511394chr19:49936217ENST00000221485612138_140289561.0Topological domainCytoplasmic
TgeneSLC17A7chr19:52511394chr19:49936217ENST00000221485612162_169289561.0Topological domainExtracellular
TgeneSLC17A7chr19:52511394chr19:49936217ENST00000221485612191_208289561.0Topological domainCytoplasmic
TgeneSLC17A7chr19:52511394chr19:49936217ENST000002214856121_63289561.0Topological domainCytoplasmic
TgeneSLC17A7chr19:52511394chr19:49936217ENST00000221485612230_236289561.0Topological domainExtracellular
TgeneSLC17A7chr19:52511394chr19:49936217ENST00000221485612258_302289561.0Topological domainCytoplasmic
TgeneSLC17A7chr19:52511394chr19:49936217ENST0000022148561285_116289561.0Topological domainExtracellular
TgeneSLC17A7chr19:52511394chr19:49936217ENST00000221485612117_137289561.0TransmembraneHelical
TgeneSLC17A7chr19:52511394chr19:49936217ENST00000221485612141_161289561.0TransmembraneHelical
TgeneSLC17A7chr19:52511394chr19:49936217ENST00000221485612170_190289561.0TransmembraneHelical
TgeneSLC17A7chr19:52511394chr19:49936217ENST00000221485612209_229289561.0TransmembraneHelical
TgeneSLC17A7chr19:52511394chr19:49936217ENST00000221485612237_257289561.0TransmembraneHelical
TgeneSLC17A7chr19:52511394chr19:49936217ENST0000022148561264_84289561.0TransmembraneHelical


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Fusion Gene Sequence for ZNF615-SLC17A7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>102566_102566_1_ZNF615-SLC17A7_ZNF615_chr19_52511394_ENST00000391795_SLC17A7_chr19_49936217_ENST00000221485_length(transcript)=2024nt_BP=90nt
AAACGCTGGGAACGCCTCCGACCCTGGATAGTCGCCGTCAGGCACTGAGGAGGCCGAGAGATGAGGCCGGAGCCCACCAAGTTCTGGGAA
AAGTTTAGCACTCCCTGGCGGCGCTTCTTCACGTCTATGCCAGTCTATGCCATCATCGTGGCCAACTTCTGCCGCAGCTGGACGTTCTAC
CTGCTGCTCATCTCCCAGCCCGCCTACTTCGAAGAAGTGTTCGGCTTCGAGATCAGCAAGGTAGGCCTGGTGTCCGCGCTGCCCCACCTG
GTCATGACCATCATCGTGCCCATCGGCGGCCAGATCGCGGACTTCCTGCGGAGCCGCCGCATCATGTCCACCACCAACGTGCGCAAGTTG
ATGAACTGCGGAGGCTTCGGCATGGAAGCCACGCTGCTGTTGGTGGTCGGCTACTCGCACTCCAAGGGCGTGGCCATCTCCTTCCTGGTC
CTAGCCGTGGGCTTCAGCGGCTTCGCCATCTCTGGGTTCAACGTGAACCACCTGGACATAGCCCCGCGCTACGCCAGCATCCTCATGGGC
ATCTCCAACGGCGTGGGCACACTGTCGGGCATGGTGTGCCCCATCATCGTGGGGGCCATGACTAAGCACAAGACTCGGGAGGAGTGGCAG
TACGTGTTCCTAATTGCCTCCCTGGTGCACTATGGAGGTGTCATCTTCTACGGGGTCTTTGCTTCTGGAGAGAAGCAGCCGTGGGCAGAG
CCTGAGGAGATGAGCGAGGAGAAGTGTGGCTTCGTTGGCCATGACCAGCTGGCTGGCAGTGACGACAGCGAAATGGAGGATGAGGCTGAG
CCCCCGGGGGCACCCCCTGCACCCCCGCCCTCCTATGGGGCCACACACAGCACATTTCAGCCCCCCAGGCCCCCACCCCCTGTCCGGGAC
TACTGACCATGTGCCTCCCACTGAATGGCAGTTTCCAGGACCTCCATTCCACTCATCTCTGGCCTGAGTGACAGTGTCAAGGAACCCTGC
TCCTCTCTGTCCTGCCTCAGGCCTAAGAAGCACTCTCCCTTGTTCCCAGTGCTGTCAAATCCTCTTTCCTTCCCAATTGCCTCTCAGGGG
TAGTGAAGCTGCAGACTGACAGTTTCAAGGATACCCAAATTCCCCTAAAGGTTCCCTCTCCACCCGTTCTGCCTCAGTGGTTTCAAATCT
CTCCTTTCAGGGCTTTATTTGAATGGACAGTTCGACCTCTTACTCTCTCTTGTGGTTTTGAGGCACCCACACCCCCCGCTTTCCTTTATC
TCCAGGGACTCTCAGGCTAACCTTTGAGATCACTCAGCTCCCATCTCCTTTCAGAAAAATTCAAGGTCCTCCTCTAGAAGTTTCAAATCT
CTCCCAACTCTGTTCTGCATCTTCCAGATTGGTTTAACCAATTACTCGTCCCCGCCATTCCAGGGATTGATTCTCACCAGCGTTTCTGAT
GGAAAATGGCGGTTTCAAGTCCCCGATTCCGTGCCCACTTCACATCTCCCCTACCAGCAGATTCTGCGAAAGCACCAAATTTCTCAAGAC
CCTCTTCTCCCTAGCTTAGCATAATGTCTGGGGAAACAACCAAAATCGCAATTTTAACAATATGCCTCTCTACCCCCGTGCACTTTTTCT
GACATGGTTTTCAGGTCTAAATAGTGGCTGCTCCAGTCCATGAACTCAAAGGTTTGAAGCTACCACCATTGAACTCCCCCATGGTGGTTT
CATGATGCCCCCTCCCCAATTCCTCGCACTTTATTCTCCTGGGTGGTTTCGAACTACCCTGTTTCTCAGTGGCCATTTGTTGTGTCCCTC
AGGGGCTTAATGACTCAAAATCTGGGATCCTTCCCCTCTCAGACACCCCTCTTTCAGCTTAGAATTTGGGGAACCTATAGAGAAGTCACA
GAATCCCATGAAAGGGAATGGGGCAGGAGCCAGGGGTGTTTTTTCCCAGTGCAGGGTTGTGTCTTTGTGTCTCTGTCTCTGTGACTGTAA

>102566_102566_1_ZNF615-SLC17A7_ZNF615_chr19_52511394_ENST00000391795_SLC17A7_chr19_49936217_ENST00000221485_length(amino acids)=281AA_BP=10
MRPEPTKFWEKFSTPWRRFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLVSALPHLVMTIIVPIGGQIADFLRSRR
IMSTTNVRKLMNCGGFGMEATLLLVVGYSHSKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAM
TKHKTREEWQYVFLIASLVHYGGVIFYGVFASGEKQPWAEPEEMSEEKCGFVGHDQLAGSDDSEMEDEAEPPGAPPAPPPSYGATHSTFQ

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>102566_102566_2_ZNF615-SLC17A7_ZNF615_chr19_52511394_ENST00000391795_SLC17A7_chr19_49936217_ENST00000543531_length(transcript)=1439nt_BP=90nt
AAACGCTGGGAACGCCTCCGACCCTGGATAGTCGCCGTCAGGCACTGAGGAGGCCGAGAGATGAGGCCGGAGCCCACCAAGTTCTGGGAA
AAGTTTAGCACTCCCTGGCGGCGCTTCTTCACGTCTATGCCAGTCTATGCCATCATCGTGGCCAACTTCTGCCGCAGCTGGACGTTCTAC
CTGCTGCTCATCTCCCAGCCCGCCTACTTCGAAGAAGTGTTCGGCTTCGAGATCAGCAAGGTAGGCCTGGTGTCCGCGCTGCCCCACCTG
GTCATGACCATCATCGTGCCCATCGGCGGCCAGATCGCGGACTTCCTGCGGAGCCGCCGCATCATGTCCACCACCAACGTGCGCAAGTTG
ATGAACTGCGGAGGCTTCGGCATGGAAGCCACGCTGCTGTTGGTGGTCGGCTACTCGCACTCCAAGGGCGTGGCCATCTCCTTCCTGGTC
CTAGCCGTGGGCTTCAGCGGCTTCGCCATCTCTGGGTTCAACGTGAACCACCTGGACATAGCCCCGCGCTACGCCAGCATCCTCATGGGC
ATCTCCAACGGCGTGGGCACACTGTCGGGCATGGTGTGCCCCATCATCGTGGGGGCCATGACTAAGCACAAGACTCGGGAGGAGTGGCAG
TACGTGTTCCTAATTGCCTCCCTGGTGCACTATGGAGGTGTCATCTTCTACGGGGTCTTTGCTTCTGGAGAGAAGCAGCCGTGGGCAGAG
CCTGAGGAGATGAGCGAGGAGAAGTGTGGCTTCGTTGGCCATGACCAGCTGGCTGGCAGTGACGACAGCGAAATGGAGGATGAGGCTGAG
CCCCCGGGGGCACCCCCTGCACCCCCGCCCTCCTATGGGGCCACACACAGCACATTTCAGCCCCCCAGGCCCCCACCCCCTGTCCGGGAC
TACTGACCATGTGCCTCCCACTGAATGGCAGTTTCCAGGACCTCCATTCCACTCATCTCTGGCCTGAGTGACAGTGTCAAGGAACCCTGC
TCCTCTCTGTCCTGCCTCAGGCCTAAGAAGCACTCTCCCTTGTTCCCAGTGCTGTCAAATCCTCTTTCCTTCCCAATTGCCTCTCAGGGG
TAGTGAAGCTGCAGACTGACAGTTTCAAGGATACCCAAATTCCCCTAAAGGTTCCCTCTCCACCCGTTCTGCCTCAGTGGTTTCAAATCT
CTCCTTTCAGGGCTTTATTTGAATGGACAGTTCGACCTCTTACTCTCTCTTGTGGTTTTGAGGCACCCACACCCCCCGCTTTCCTTTATC
TCCAGGGACTCTCAGGCTAACCTTTGAGATCACTCAGCTCCCATCTCCTTTCAGAAAAATTCAAGGTCCTCCTCTAGAAGTTTCAAATCT

>102566_102566_2_ZNF615-SLC17A7_ZNF615_chr19_52511394_ENST00000391795_SLC17A7_chr19_49936217_ENST00000543531_length(amino acids)=281AA_BP=10
MRPEPTKFWEKFSTPWRRFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLVSALPHLVMTIIVPIGGQIADFLRSRR
IMSTTNVRKLMNCGGFGMEATLLLVVGYSHSKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAM
TKHKTREEWQYVFLIASLVHYGGVIFYGVFASGEKQPWAEPEEMSEEKCGFVGHDQLAGSDDSEMEDEAEPPGAPPAPPPSYGATHSTFQ

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>102566_102566_3_ZNF615-SLC17A7_ZNF615_chr19_52511394_ENST00000391795_SLC17A7_chr19_49936217_ENST00000600601_length(transcript)=1439nt_BP=90nt
AAACGCTGGGAACGCCTCCGACCCTGGATAGTCGCCGTCAGGCACTGAGGAGGCCGAGAGATGAGGCCGGAGCCCACCAAGTTCTGGGAA
AAGTTTAGCACTCCCTGGCGGCGCTTCTTCACGTCTATGCCAGTCTATGCCATCATCGTGGCCAACTTCTGCCGCAGCTGGACGTTCTAC
CTGCTGCTCATCTCCCAGCCCGCCTACTTCGAAGAAGTGTTCGGCTTCGAGATCAGCAAGGTAGGCCTGGTGTCCGCGCTGCCCCACCTG
GTCATGACCATCATCGTGCCCATCGGCGGCCAGATCGCGGACTTCCTGCGGAGCCGCCGCATCATGTCCACCACCAACGTGCGCAAGTTG
ATGAACTGCGGAGGCTTCGGCATGGAAGCCACGCTGCTGTTGGTGGTCGGCTACTCGCACTCCAAGGGCGTGGCCATCTCCTTCCTGGTC
CTAGCCGTGGGCTTCAGCGGCTTCGCCATCTCTGGGTTCAACGTGAACCACCTGGACATAGCCCCGCGCTACGCCAGCATCCTCATGGGC
ATCTCCAACGGCGTGGGCACACTGTCGGGCATGGTGTGCCCCATCATCGTGGGGGCCATGACTAAGCACAAGACTCGGGAGGAGTGGCAG
TACGTGTTCCTAATTGCCTCCCTGGTGCACTATGGAGGTGTCATCTTCTACGGGGTCTTTGCTTCTGGAGAGAAGCAGCCGTGGGCAGAG
CCTGAGGAGATGAGCGAGGAGAAGTGTGGCTTCGTTGGCCATGACCAGCTGGCTGGCAGTGACGACAGCGAAATGGAGGATGAGGCTGAG
CCCCCGGGGGCACCCCCTGCACCCCCGCCCTCCTATGGGGCCACACACAGCACATTTCAGCCCCCCAGGCCCCCACCCCCTGTCCGGGAC
TACTGACCATGTGCCTCCCACTGAATGGCAGTTTCCAGGACCTCCATTCCACTCATCTCTGGCCTGAGTGACAGTGTCAAGGAACCCTGC
TCCTCTCTGTCCTGCCTCAGGCCTAAGAAGCACTCTCCCTTGTTCCCAGTGCTGTCAAATCCTCTTTCCTTCCCAATTGCCTCTCAGGGG
TAGTGAAGCTGCAGACTGACAGTTTCAAGGATACCCAAATTCCCCTAAAGGTTCCCTCTCCACCCGTTCTGCCTCAGTGGTTTCAAATCT
CTCCTTTCAGGGCTTTATTTGAATGGACAGTTCGACCTCTTACTCTCTCTTGTGGTTTTGAGGCACCCACACCCCCCGCTTTCCTTTATC
TCCAGGGACTCTCAGGCTAACCTTTGAGATCACTCAGCTCCCATCTCCTTTCAGAAAAATTCAAGGTCCTCCTCTAGAAGTTTCAAATCT

>102566_102566_3_ZNF615-SLC17A7_ZNF615_chr19_52511394_ENST00000391795_SLC17A7_chr19_49936217_ENST00000600601_length(amino acids)=281AA_BP=10
MRPEPTKFWEKFSTPWRRFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLVSALPHLVMTIIVPIGGQIADFLRSRR
IMSTTNVRKLMNCGGFGMEATLLLVVGYSHSKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAM
TKHKTREEWQYVFLIASLVHYGGVIFYGVFASGEKQPWAEPEEMSEEKCGFVGHDQLAGSDDSEMEDEAEPPGAPPAPPPSYGATHSTFQ

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Fusion Gene PPI Analysis for ZNF615-SLC17A7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF615-SLC17A7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF615-SLC17A7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource