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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF616-TRAPPC8 (FusionGDB2 ID:102567)

Fusion Gene Summary for ZNF616-TRAPPC8

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF616-TRAPPC8
Fusion gene ID: 102567
HgeneTgene
Gene symbol

ZNF616

TRAPPC8

Gene ID

90317

22878

Gene namezinc finger protein 616trafficking protein particle complex 8
Synonyms-GSG1|HsT2706|KIAA1012|TRS85
Cytomap

19q13.41

18q12.1

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 616trafficking protein particle complex subunit 8general sporulation gene 1 homologprotein TRS85 homolog
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000330123, ENST00000596290, 
ENST00000597013, ENST00000600228, 
ENST00000582513, ENST00000582539, 
ENST00000584876, ENST00000283351, 
Fusion gene scores* DoF score1 X 1 X 1=118 X 15 X 6=1620
# samples 118
** MAII scorelog2(1/1*10)=3.32192809488736log2(18/1620*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF616 [Title/Abstract] AND TRAPPC8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF616(52633754)-TRAPPC8(29511486), # samples:2
Anticipated loss of major functional domain due to fusion event.ZNF616-TRAPPC8 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ZNF616-TRAPPC8 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ZNF616 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TRAPPC8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ACCTCGA-OR-A5LL-01AZNF616chr19

52633754

-TRAPPC8chr18

29511486

-


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Fusion Gene ORF analysis for ZNF616-TRAPPC8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000330123ENST00000582513ZNF616chr19

52633754

-TRAPPC8chr18

29511486

-
5CDS-5UTRENST00000330123ENST00000582539ZNF616chr19

52633754

-TRAPPC8chr18

29511486

-
5CDS-5UTRENST00000330123ENST00000584876ZNF616chr19

52633754

-TRAPPC8chr18

29511486

-
5CDS-5UTRENST00000596290ENST00000582513ZNF616chr19

52633754

-TRAPPC8chr18

29511486

-
5CDS-5UTRENST00000596290ENST00000582539ZNF616chr19

52633754

-TRAPPC8chr18

29511486

-
5CDS-5UTRENST00000596290ENST00000584876ZNF616chr19

52633754

-TRAPPC8chr18

29511486

-
5CDS-5UTRENST00000597013ENST00000582513ZNF616chr19

52633754

-TRAPPC8chr18

29511486

-
5CDS-5UTRENST00000597013ENST00000582539ZNF616chr19

52633754

-TRAPPC8chr18

29511486

-
5CDS-5UTRENST00000597013ENST00000584876ZNF616chr19

52633754

-TRAPPC8chr18

29511486

-
5CDS-5UTRENST00000600228ENST00000582513ZNF616chr19

52633754

-TRAPPC8chr18

29511486

-
5CDS-5UTRENST00000600228ENST00000582539ZNF616chr19

52633754

-TRAPPC8chr18

29511486

-
5CDS-5UTRENST00000600228ENST00000584876ZNF616chr19

52633754

-TRAPPC8chr18

29511486

-
Frame-shiftENST00000330123ENST00000283351ZNF616chr19

52633754

-TRAPPC8chr18

29511486

-
In-frameENST00000596290ENST00000283351ZNF616chr19

52633754

-TRAPPC8chr18

29511486

-
In-frameENST00000597013ENST00000283351ZNF616chr19

52633754

-TRAPPC8chr18

29511486

-
In-frameENST00000600228ENST00000283351ZNF616chr19

52633754

-TRAPPC8chr18

29511486

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000600228ZNF616chr1952633754-ENST00000283351TRAPPC8chr1829511486-600727427944241381
ENST00000596290ZNF616chr1952633754-ENST00000283351TRAPPC8chr1829511486-601227928444291381
ENST00000597013ZNF616chr1952633754-ENST00000283351TRAPPC8chr1829511486-599426126644111381

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000600228ENST00000283351ZNF616chr1952633754-TRAPPC8chr1829511486-0.0001974340.99980253
ENST00000596290ENST00000283351ZNF616chr1952633754-TRAPPC8chr1829511486-0.0001982850.9998017
ENST00000597013ENST00000283351ZNF616chr1952633754-TRAPPC8chr1829511486-0.0001945160.9998055

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Fusion Genomic Features for ZNF616-TRAPPC8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF616-TRAPPC8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:52633754/chr18:29511486)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF616chr19:52633754chr18:29511486ENST00000600228-247_844782.0DomainKRAB
HgeneZNF616chr19:52633754chr18:29511486ENST00000600228-24185_2074782.0Zinc fingerC2H2-type 1
HgeneZNF616chr19:52633754chr18:29511486ENST00000600228-24213_2354782.0Zinc fingerC2H2-type 2
HgeneZNF616chr19:52633754chr18:29511486ENST00000600228-24241_2634782.0Zinc fingerC2H2-type 3
HgeneZNF616chr19:52633754chr18:29511486ENST00000600228-24269_2914782.0Zinc fingerC2H2-type 4
HgeneZNF616chr19:52633754chr18:29511486ENST00000600228-24297_3194782.0Zinc fingerC2H2-type 5
HgeneZNF616chr19:52633754chr18:29511486ENST00000600228-24325_3474782.0Zinc fingerC2H2-type 6
HgeneZNF616chr19:52633754chr18:29511486ENST00000600228-24353_3754782.0Zinc fingerC2H2-type 7
HgeneZNF616chr19:52633754chr18:29511486ENST00000600228-24381_4034782.0Zinc fingerC2H2-type 8
HgeneZNF616chr19:52633754chr18:29511486ENST00000600228-24409_4314782.0Zinc fingerC2H2-type 9
HgeneZNF616chr19:52633754chr18:29511486ENST00000600228-24437_4594782.0Zinc fingerC2H2-type 10
HgeneZNF616chr19:52633754chr18:29511486ENST00000600228-24465_4874782.0Zinc fingerC2H2-type 11
HgeneZNF616chr19:52633754chr18:29511486ENST00000600228-24493_5154782.0Zinc fingerC2H2-type 12
HgeneZNF616chr19:52633754chr18:29511486ENST00000600228-24521_5434782.0Zinc fingerC2H2-type 13
HgeneZNF616chr19:52633754chr18:29511486ENST00000600228-24549_5714782.0Zinc fingerC2H2-type 14
HgeneZNF616chr19:52633754chr18:29511486ENST00000600228-24577_5994782.0Zinc fingerC2H2-type 15
HgeneZNF616chr19:52633754chr18:29511486ENST00000600228-24605_6274782.0Zinc fingerC2H2-type 16
HgeneZNF616chr19:52633754chr18:29511486ENST00000600228-24633_6554782.0Zinc fingerC2H2-type 17
HgeneZNF616chr19:52633754chr18:29511486ENST00000600228-24661_6834782.0Zinc fingerC2H2-type 18
HgeneZNF616chr19:52633754chr18:29511486ENST00000600228-24689_7114782.0Zinc fingerC2H2-type 19
HgeneZNF616chr19:52633754chr18:29511486ENST00000600228-24717_7394782.0Zinc fingerC2H2-type 20
HgeneZNF616chr19:52633754chr18:29511486ENST00000600228-24745_7674782.0Zinc fingerC2H2-type 21


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Fusion Gene Sequence for ZNF616-TRAPPC8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>102567_102567_1_ZNF616-TRAPPC8_ZNF616_chr19_52633754_ENST00000596290_TRAPPC8_chr18_29511486_ENST00000283351_length(transcript)=6012nt_BP=279nt
TGCGCCAGGGAAAGGCCTTATCGCTGTGTGTGTGTTTCAGTCTACGTGGATTAAACATTACTTCGCTCCGTCTGCCTGGATTAAACGTGC
ACTTTGCAGTCCTCACTTCTCCGTACCAGTGATCTGGGGATCGCTACGGACCTTAAAATACCCATAGCCCCTTCGCCCCTGCAACAGGCA
CTTCTCCCCACGTTTGATGTGTGAATAATTACATTGACTGAGAAAGAAACCCAGAAGAGGAAGAAGAGGAAGGAAAAGGAGTCAGTGATG
GCTACTCAGTTCACATGAGAGATCCTAATAATCAACTTCACGTAATTAAAAATTTGAAGATAGCAGTAAGCAACATTGTCACCCAGCCAC
CTCAGCCTGGAGCCATCCGGAAGCTTTTGAATGATGTTGTTTCTGGCAGTCAGCCTGCAGAAGGATTAGTAGCTAATGTGATTACAGCAG
GAGATTATGACCTTAACATCAGTGCCACTACTCCATGGTTTGAGTCTTACAGAGAAACCTTTCTTCAGTCGATGCCAGCATTGGATCATG
AATTTCTGAACCACTATTTAGCATGTATGTTGGTAGCGTCATCTAGTGAAGCTGAACCTGTGGAACAGTTTTCAAAGTTGTCACAAGAAC
AGCATCGAATTCAGCACAACAGTGATTATTCCTACCCCAAGTGGTTTATACCAAATACACTTAAATACTATGTACTTTTACATGATGTAA
GTGCAGGAGATGAACAGAGAGCTGAATCAATTTATGAAGAAATGAAACAGAAATATGGAACTCAGGGTTGCTATTTACTTAAAATTAATT
CTCGAACATCTAATCGAGCATCAGATGAACAGATACCAGATCCTTGGAGTCAGTATCTCCAGAAAAATAGTATTCAAAACCAGGAATCAT
ATGAAGATGGCCCTTGTACTATAACTTCAAATAAGAATTCTGATAATAACTTGCTTTCATTGGATGGATTAGATAACGAAGTCAAAGATG
GCTTACCAAATAACTTTAGAGCTCACCCACTTCAGTTGGAGCAATCCAGTGACCCTTCTAACAGTATTGATGGCCCAGATCATCTAAGAT
CTGCTTCATCGTTACATGAAACAAAGAAAGGAAATACTGGAATAATTCATGGTGCATGTTTAACACTTACTGATCATGATAGAATTCGAC
AGTTTATACAAGAGTTCACATTTCGGGGCCTTTTGCCACATATAGAGAAAACAATTAGGCAATTAAACGATCAGCTAATATCAAGAAAAG
GTTTGAGTCGATCTCTATTTTCTGCAACTAAAAAATGGTTTAGTGGCAGTAAAGTTCCAGAAAAGAGCATTAATGACCTGAAAAATACAT
CTGGCTTGCTGTATCCGCCGGAAGCACCAGAACTTCAAATCAGGAAAATGGCTGACTTATGTTTTTTGGTGCAGCATTATGATTTGGCTT
ACAGTTGCTATCATACTGCAAAGAAAGATTTTCTTAATGATCAAGCAATGCTTTATGCAGCTGGTGCCTTGGAAATGGCAGCAGTGTCTG
CTTTTCTTCAACCAGGAGCACCTAGGCCATATCCTGCTCATTACATGGATACAGCAATTCAGACATACAGAGATATCTGCAAGAATATGG
TGTTGGCTGAAAGATGTGTGTTGCTTAGTGCTGAACTTTTAAAAAGCCAAAGCAAATATTCAGAGGCTGCAGCTCTCCTAATACGGTTGA
CCAGTGAGGATTCTGATCTTCGAAGTGCACTTCTTTTGGAACAGGCAGCACATTGCTTTATAAACATGAAAAGTCCCATGGTTAGAAAAT
ATGCATTTCATATGATATTGGCAGGCCATCGATTTAGTAAAGCAGGGCAGAAAAAGCATGCTTTACGCTGTTATTGTCAAGCCATGCAAG
TTTACAAAGGAAAAGGCTGGTCTCTTGCAGAGGATCACATTAATTTCACTATTGGGCGCCAGTCCTATACTCTTAGACAGCTGGATAATG
CTGTGTCTGCTTTTAGGCATATTCTAATTAATGAAAGTAAACAATCTGCTGCTCAACAGGGGGCTTTCCTCAGAGAATATCTTTATGTTT
ACAAGAATGTAAGTCAGCTGTCACCAGATGGTCCTTTGCCACAGCTTCCTTTACCGTATATTAACAGTTCAGCAACACGGGTTTTTTTTG
GCCATGACAGACGACCAGCGGATGGTGAAAAACAAGCAGCTACTCATGTAAGTCTTGATCAAGAATATGATTCTGAATCCTCTCAGCAGT
GGCGAGAACTTGAGGAACAAGTTGTTTCTGTGGTTAACAAAGGAGTAATTCCATCCAATTTTCATCCCACACAATACTGTTTGAACAGTT
ACTCAGATAATTCAAGATTTCCACTTGCAGTTGTAGAAGAACCAATTACAGTGGAAGTGGCTTTTAGAAACCCTTTGAAAGTTCTACTTT
TGTTGACTGATTTGTCATTGCTTTGGAAGTTTCATCCTAAAGATTTCAGTGGAAAGGATAATGAAGAAGTTAAACAACTAGTTACAAGTG
AACCTGAAATGATTGGAGCTGAAGTTATTTCAGAGTTCTTAATTAATGGCGAAGAATCAAAAGTGGCAAGACTAAAGCTCTTTCCCCATC
ACATAGGGGAGCTGCATATTCTGGGAGTTGTTTATAATCTTGGCACTATTCAGGGCTCTATGACAGTAGATGGCATTGGTGCTCTTCCCG
GATGTCACACAGGAAAATATTCCTTGAGTATGTCAGTCCGAGGGAAGCAGGATTTAGAAATTCAAGGTCCTCGACTTAACAACACAAAAG
AAGAGAAAACATCTGTTAAATATGGCCCTGATCGACGTTTAGATCCCATAATCACAGAAGAAATGCCACTGTTGGAGGTGTTCTTTATAC
ATTTTCCTACAGGGCTTCTCTGTGGAGAAATCCGAAAAGCATATGTAGAATTTGTCAATGTCAGCAAATGTCCACTTACTGGATTGAAGG
TTGTTTCTAAACGTCCAGAGTTCTTTACTTTCGGTGGTAATACTGCTGTTCTAACACCACTAAGTCCCTCAGCTTCTGAGAATTGTAGTG
CTTACAAGACTGTTGTGACAGATGCTACCTCTGTGTGTACAGCACTCATATCATCAGCTTCTTCTGTAGACTTTGGCATTGGCACAGGAA
GTCAACCAGAGGTGATTCCTGTTCCCCTTCCTGACACTGTTCTTCTACCCGGAGCCTCAGTGCAGCTGCCAATGTGGTTACGTGGGCCTG
ATGAAGAAGGTGTCCATGAAATTAACTTTTTGTTTTACTATGAAAGTGTCAAAAAGCAGCCAAAAATACGGCACAGAATATTAAGACACA
CTGCAATTATTTGTACCAGTCGGTCTTTAAATGTACGGGCCACTGTCTGCAGAAGTAATTCTCTTGAAAATGAAGAAGGCAGAGGAGGCA
ATATGCTAGTCTTTGTGGATGTGGAAAATACCAATACTAGTGAAGCAGGCGTTAAGGAATTCCACATAGTGCAAGTATCAAGTAGTAGCA
AACACTGGAAGTTACAGAAATCTGTAAATCTTTCTGAAAACAAAGATACCAAACTTGCCAGTAGGGAGAAGGGAAAGTTTTGCTTTAAGG
CAATAAGATGTGAGAAAGAAGAAGCGGCCACACAGTCCTCTGAAAAATATACCTTTGCAGATATCATCTTTGGAAATGAACAGATAATAA
GTTCAGCAAGCCCATGTGCAGACTTCTTTTATCGAAGTTTATCTTCTGAATTGAAAAAACCACAAGCTCACTTGCCTGTGCATACAGAAA
AACAGTCAACAGAGGATGCTGTGAGATTGATTCAAAAATGCAGTGAGGTAGATTTGAATATTGTCATATTATGGAAGGCATACGTTGTGG
AAGACAGTAAACAGCTTATTTTGGAAGGTCAACATCATGTTATTCTTCGCACTATAGGAAAAGAAGCCTTTTCATATCCTCAGAAACAGG
AGCCACCAGAAATGGAACTATTGAAATTTTTCAGGCCAGAAAACATTACAGTTTCCTCAAGGCCATCAGTAGAGCAGCTTTCTAGTCTCA
TTAAAACGAGTCTTCACTACCCAGAATCATTTAATCATCCATTTCATCAAAAAAGCCTTTGTTTAGTACCAGTCACTCTTTTACTTTCCA
ATTGTTCTAAGGCTGATGTAGATGTCATAGTTGATCTTCGGCATAAAACAACAAGTCCAGAAGCACTGGAAATCCATGGATCATTCACAT
GGCTTGGACAAACACAGTATAAACTTCAACTTAAAAGCCAGGAGATTCACAGTCTGCAGCTGAAAGCATGCTTTGTTCATACAGGTGTTT
ATAACCTTGGAACTCCTAGGGTATTTGCCAAGTTATCGGACCAAGTTACAGTGTTTGAAACAAGTCAGCAGAATTCCATGCCTGCCCTGA
TCATCATCAGTAATGTGTGACAACTTGGAAATTTGTACTGAAATCCACAATAATCAGTTTTTGCTGGATGGGTTTTACAGCAGTATTTGA
TATACCTAACTTGTTATGGAGGTTGATTGATATCTGATCCCTGCAAAATACTTTGACTTGTCATTTTGTTGATGATGCAAAGCACGTTGG
ACTGAGAATACTTAACATTCTTTTTCTGTATTTCTTTAAACCCTGAGAATAATTTACATGCTCATAATACAGGATATCAGCATATTTGTG
CACCTTATTAAGCCCCATCTTAAGAAAACACAAAGTCTAAGTCTGCTGTTACAACTTGTCAATGGTATACGAATATTAGGAGATGATTCT
GAGAAAGGAAAGGCCTTGTTGGCAGTACTCCTGTTAAGCCATTAGTCTCTAAATTCCAGCTTTACTGTGAAGTTCTATAGAGTGTTAAAT
ACAAATTTTCCTGTCTTGCTTCACACAGTTCCTTAAAATCAGTTTTGAACTTTGGTCATAGAGTCTTCATATTTCAGTATTTGGTGGTCC
CTATGACTTATACATAACTTTGTAAAAAGAAAAAAAAATTTTTTCTGATGCTTTGAATATAGTTTTGAAAGGAGTTTTGACTTTTTTCCC
CTCATTCATCTCAGTATAGAGTGCGCTATTTCACAATACGATTTTTGTCATTAAAATTACCATATTCTTTATTATATAACGTTAACTATT
GAGTTGATCTGTTTAAAATATAAATCTCAAGTTAATTAAAAATAAGCTTTTCAAAAATGTATTATATTTATAACAAATATACTGTAAATA
GAATAAAGACATGCTATTCACTGTATAGCGTATTAGTATCTGTTGATTAGAAAGTCTGGTTTCAAAATATTTTTTTATTCAGAGAATGGG
CATTTGGACATAAGAAATTTCAATTCAGCCCTGCTGCAGATAGAGAAATGGGAGCAAGGTTGTTTCAATGAATATCTCTTGTCATTGGAG
AAGGAGGGAAGACAGGGTGTAGGAGTGGGTGGCAGGGAGTACAAGAGCCAGGGTCAGTCAAGTCTGGAGCAGATGGGGTCCTTGTGCCAT
TGACAGCTACCATGGTTTGTTCCAGTCTCAATCTCGGCACTAATCGGAGCAGACTGCACCAAAGTGGGGAGAGATCAAAAGACCCCGTTT
TCAGACTGAAGATTCCAAACCTGTACTTGGAACAACTCTTCTTGAGAGATGGGTGGCTAGTCTGTGTGCCTCTCTGCAACTGCTGCTTAT
GCTTCTGGATCTTAAGTGGGTCTCTGGCTTTTCAGCTCCTTCCACTCTGTGTCTTAGCAGGTGTGGGACAAGTTGGAGAGGAAGGTCACA
TTCTAAGGACACTCATTTCCTTCTTGAGAGTTTAGGGCCATGGGCTTATAAAAAGTCTGAGGAGGAAAGACAAGAATGAGGAGGCATAAT
CACAGTGGTATCTCATATTTAAACCACTCAGCTGAATATTAAATTGAACCGATTGTTAAACAGACACTAATAAAAAAATTAAACTATATA

>102567_102567_1_ZNF616-TRAPPC8_ZNF616_chr19_52633754_ENST00000596290_TRAPPC8_chr18_29511486_ENST00000283351_length(amino acids)=1381AA_BP=0
MRDPNNQLHVIKNLKIAVSNIVTQPPQPGAIRKLLNDVVSGSQPAEGLVANVITAGDYDLNISATTPWFESYRETFLQSMPALDHEFLNH
YLACMLVASSSEAEPVEQFSKLSQEQHRIQHNSDYSYPKWFIPNTLKYYVLLHDVSAGDEQRAESIYEEMKQKYGTQGCYLLKINSRTSN
RASDEQIPDPWSQYLQKNSIQNQESYEDGPCTITSNKNSDNNLLSLDGLDNEVKDGLPNNFRAHPLQLEQSSDPSNSIDGPDHLRSASSL
HETKKGNTGIIHGACLTLTDHDRIRQFIQEFTFRGLLPHIEKTIRQLNDQLISRKGLSRSLFSATKKWFSGSKVPEKSINDLKNTSGLLY
PPEAPELQIRKMADLCFLVQHYDLAYSCYHTAKKDFLNDQAMLYAAGALEMAAVSAFLQPGAPRPYPAHYMDTAIQTYRDICKNMVLAER
CVLLSAELLKSQSKYSEAAALLIRLTSEDSDLRSALLLEQAAHCFINMKSPMVRKYAFHMILAGHRFSKAGQKKHALRCYCQAMQVYKGK
GWSLAEDHINFTIGRQSYTLRQLDNAVSAFRHILINESKQSAAQQGAFLREYLYVYKNVSQLSPDGPLPQLPLPYINSSATRVFFGHDRR
PADGEKQAATHVSLDQEYDSESSQQWRELEEQVVSVVNKGVIPSNFHPTQYCLNSYSDNSRFPLAVVEEPITVEVAFRNPLKVLLLLTDL
SLLWKFHPKDFSGKDNEEVKQLVTSEPEMIGAEVISEFLINGEESKVARLKLFPHHIGELHILGVVYNLGTIQGSMTVDGIGALPGCHTG
KYSLSMSVRGKQDLEIQGPRLNNTKEEKTSVKYGPDRRLDPIITEEMPLLEVFFIHFPTGLLCGEIRKAYVEFVNVSKCPLTGLKVVSKR
PEFFTFGGNTAVLTPLSPSASENCSAYKTVVTDATSVCTALISSASSVDFGIGTGSQPEVIPVPLPDTVLLPGASVQLPMWLRGPDEEGV
HEINFLFYYESVKKQPKIRHRILRHTAIICTSRSLNVRATVCRSNSLENEEGRGGNMLVFVDVENTNTSEAGVKEFHIVQVSSSSKHWKL
QKSVNLSENKDTKLASREKGKFCFKAIRCEKEEAATQSSEKYTFADIIFGNEQIISSASPCADFFYRSLSSELKKPQAHLPVHTEKQSTE
DAVRLIQKCSEVDLNIVILWKAYVVEDSKQLILEGQHHVILRTIGKEAFSYPQKQEPPEMELLKFFRPENITVSSRPSVEQLSSLIKTSL
HYPESFNHPFHQKSLCLVPVTLLLSNCSKADVDVIVDLRHKTTSPEALEIHGSFTWLGQTQYKLQLKSQEIHSLQLKACFVHTGVYNLGT

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>102567_102567_2_ZNF616-TRAPPC8_ZNF616_chr19_52633754_ENST00000597013_TRAPPC8_chr18_29511486_ENST00000283351_length(transcript)=5994nt_BP=261nt
TATCGCTGTGTGTGTGTTTCAGTCTACGTGGATTAAACATTACTTCGCTCCGTCTGCCTGGATTAAACGTGCACTTTGCAGTCCTCACTT
CTCCGTACCAGTGATCTGGGGATCGCTACGGACCTTAAAATACCCATAGCCCCTTCGCCCCTGCAACAGGCACTTCTCCCCACGTTTGAT
GTGTGAATAATTACATTGACTGAGAAAGAAACCCAGAAGAGGAAGAAGAGGAAGGAAAAGGAGTCAGTGATGGCTACTCAGTTCACATGA
GAGATCCTAATAATCAACTTCACGTAATTAAAAATTTGAAGATAGCAGTAAGCAACATTGTCACCCAGCCACCTCAGCCTGGAGCCATCC
GGAAGCTTTTGAATGATGTTGTTTCTGGCAGTCAGCCTGCAGAAGGATTAGTAGCTAATGTGATTACAGCAGGAGATTATGACCTTAACA
TCAGTGCCACTACTCCATGGTTTGAGTCTTACAGAGAAACCTTTCTTCAGTCGATGCCAGCATTGGATCATGAATTTCTGAACCACTATT
TAGCATGTATGTTGGTAGCGTCATCTAGTGAAGCTGAACCTGTGGAACAGTTTTCAAAGTTGTCACAAGAACAGCATCGAATTCAGCACA
ACAGTGATTATTCCTACCCCAAGTGGTTTATACCAAATACACTTAAATACTATGTACTTTTACATGATGTAAGTGCAGGAGATGAACAGA
GAGCTGAATCAATTTATGAAGAAATGAAACAGAAATATGGAACTCAGGGTTGCTATTTACTTAAAATTAATTCTCGAACATCTAATCGAG
CATCAGATGAACAGATACCAGATCCTTGGAGTCAGTATCTCCAGAAAAATAGTATTCAAAACCAGGAATCATATGAAGATGGCCCTTGTA
CTATAACTTCAAATAAGAATTCTGATAATAACTTGCTTTCATTGGATGGATTAGATAACGAAGTCAAAGATGGCTTACCAAATAACTTTA
GAGCTCACCCACTTCAGTTGGAGCAATCCAGTGACCCTTCTAACAGTATTGATGGCCCAGATCATCTAAGATCTGCTTCATCGTTACATG
AAACAAAGAAAGGAAATACTGGAATAATTCATGGTGCATGTTTAACACTTACTGATCATGATAGAATTCGACAGTTTATACAAGAGTTCA
CATTTCGGGGCCTTTTGCCACATATAGAGAAAACAATTAGGCAATTAAACGATCAGCTAATATCAAGAAAAGGTTTGAGTCGATCTCTAT
TTTCTGCAACTAAAAAATGGTTTAGTGGCAGTAAAGTTCCAGAAAAGAGCATTAATGACCTGAAAAATACATCTGGCTTGCTGTATCCGC
CGGAAGCACCAGAACTTCAAATCAGGAAAATGGCTGACTTATGTTTTTTGGTGCAGCATTATGATTTGGCTTACAGTTGCTATCATACTG
CAAAGAAAGATTTTCTTAATGATCAAGCAATGCTTTATGCAGCTGGTGCCTTGGAAATGGCAGCAGTGTCTGCTTTTCTTCAACCAGGAG
CACCTAGGCCATATCCTGCTCATTACATGGATACAGCAATTCAGACATACAGAGATATCTGCAAGAATATGGTGTTGGCTGAAAGATGTG
TGTTGCTTAGTGCTGAACTTTTAAAAAGCCAAAGCAAATATTCAGAGGCTGCAGCTCTCCTAATACGGTTGACCAGTGAGGATTCTGATC
TTCGAAGTGCACTTCTTTTGGAACAGGCAGCACATTGCTTTATAAACATGAAAAGTCCCATGGTTAGAAAATATGCATTTCATATGATAT
TGGCAGGCCATCGATTTAGTAAAGCAGGGCAGAAAAAGCATGCTTTACGCTGTTATTGTCAAGCCATGCAAGTTTACAAAGGAAAAGGCT
GGTCTCTTGCAGAGGATCACATTAATTTCACTATTGGGCGCCAGTCCTATACTCTTAGACAGCTGGATAATGCTGTGTCTGCTTTTAGGC
ATATTCTAATTAATGAAAGTAAACAATCTGCTGCTCAACAGGGGGCTTTCCTCAGAGAATATCTTTATGTTTACAAGAATGTAAGTCAGC
TGTCACCAGATGGTCCTTTGCCACAGCTTCCTTTACCGTATATTAACAGTTCAGCAACACGGGTTTTTTTTGGCCATGACAGACGACCAG
CGGATGGTGAAAAACAAGCAGCTACTCATGTAAGTCTTGATCAAGAATATGATTCTGAATCCTCTCAGCAGTGGCGAGAACTTGAGGAAC
AAGTTGTTTCTGTGGTTAACAAAGGAGTAATTCCATCCAATTTTCATCCCACACAATACTGTTTGAACAGTTACTCAGATAATTCAAGAT
TTCCACTTGCAGTTGTAGAAGAACCAATTACAGTGGAAGTGGCTTTTAGAAACCCTTTGAAAGTTCTACTTTTGTTGACTGATTTGTCAT
TGCTTTGGAAGTTTCATCCTAAAGATTTCAGTGGAAAGGATAATGAAGAAGTTAAACAACTAGTTACAAGTGAACCTGAAATGATTGGAG
CTGAAGTTATTTCAGAGTTCTTAATTAATGGCGAAGAATCAAAAGTGGCAAGACTAAAGCTCTTTCCCCATCACATAGGGGAGCTGCATA
TTCTGGGAGTTGTTTATAATCTTGGCACTATTCAGGGCTCTATGACAGTAGATGGCATTGGTGCTCTTCCCGGATGTCACACAGGAAAAT
ATTCCTTGAGTATGTCAGTCCGAGGGAAGCAGGATTTAGAAATTCAAGGTCCTCGACTTAACAACACAAAAGAAGAGAAAACATCTGTTA
AATATGGCCCTGATCGACGTTTAGATCCCATAATCACAGAAGAAATGCCACTGTTGGAGGTGTTCTTTATACATTTTCCTACAGGGCTTC
TCTGTGGAGAAATCCGAAAAGCATATGTAGAATTTGTCAATGTCAGCAAATGTCCACTTACTGGATTGAAGGTTGTTTCTAAACGTCCAG
AGTTCTTTACTTTCGGTGGTAATACTGCTGTTCTAACACCACTAAGTCCCTCAGCTTCTGAGAATTGTAGTGCTTACAAGACTGTTGTGA
CAGATGCTACCTCTGTGTGTACAGCACTCATATCATCAGCTTCTTCTGTAGACTTTGGCATTGGCACAGGAAGTCAACCAGAGGTGATTC
CTGTTCCCCTTCCTGACACTGTTCTTCTACCCGGAGCCTCAGTGCAGCTGCCAATGTGGTTACGTGGGCCTGATGAAGAAGGTGTCCATG
AAATTAACTTTTTGTTTTACTATGAAAGTGTCAAAAAGCAGCCAAAAATACGGCACAGAATATTAAGACACACTGCAATTATTTGTACCA
GTCGGTCTTTAAATGTACGGGCCACTGTCTGCAGAAGTAATTCTCTTGAAAATGAAGAAGGCAGAGGAGGCAATATGCTAGTCTTTGTGG
ATGTGGAAAATACCAATACTAGTGAAGCAGGCGTTAAGGAATTCCACATAGTGCAAGTATCAAGTAGTAGCAAACACTGGAAGTTACAGA
AATCTGTAAATCTTTCTGAAAACAAAGATACCAAACTTGCCAGTAGGGAGAAGGGAAAGTTTTGCTTTAAGGCAATAAGATGTGAGAAAG
AAGAAGCGGCCACACAGTCCTCTGAAAAATATACCTTTGCAGATATCATCTTTGGAAATGAACAGATAATAAGTTCAGCAAGCCCATGTG
CAGACTTCTTTTATCGAAGTTTATCTTCTGAATTGAAAAAACCACAAGCTCACTTGCCTGTGCATACAGAAAAACAGTCAACAGAGGATG
CTGTGAGATTGATTCAAAAATGCAGTGAGGTAGATTTGAATATTGTCATATTATGGAAGGCATACGTTGTGGAAGACAGTAAACAGCTTA
TTTTGGAAGGTCAACATCATGTTATTCTTCGCACTATAGGAAAAGAAGCCTTTTCATATCCTCAGAAACAGGAGCCACCAGAAATGGAAC
TATTGAAATTTTTCAGGCCAGAAAACATTACAGTTTCCTCAAGGCCATCAGTAGAGCAGCTTTCTAGTCTCATTAAAACGAGTCTTCACT
ACCCAGAATCATTTAATCATCCATTTCATCAAAAAAGCCTTTGTTTAGTACCAGTCACTCTTTTACTTTCCAATTGTTCTAAGGCTGATG
TAGATGTCATAGTTGATCTTCGGCATAAAACAACAAGTCCAGAAGCACTGGAAATCCATGGATCATTCACATGGCTTGGACAAACACAGT
ATAAACTTCAACTTAAAAGCCAGGAGATTCACAGTCTGCAGCTGAAAGCATGCTTTGTTCATACAGGTGTTTATAACCTTGGAACTCCTA
GGGTATTTGCCAAGTTATCGGACCAAGTTACAGTGTTTGAAACAAGTCAGCAGAATTCCATGCCTGCCCTGATCATCATCAGTAATGTGT
GACAACTTGGAAATTTGTACTGAAATCCACAATAATCAGTTTTTGCTGGATGGGTTTTACAGCAGTATTTGATATACCTAACTTGTTATG
GAGGTTGATTGATATCTGATCCCTGCAAAATACTTTGACTTGTCATTTTGTTGATGATGCAAAGCACGTTGGACTGAGAATACTTAACAT
TCTTTTTCTGTATTTCTTTAAACCCTGAGAATAATTTACATGCTCATAATACAGGATATCAGCATATTTGTGCACCTTATTAAGCCCCAT
CTTAAGAAAACACAAAGTCTAAGTCTGCTGTTACAACTTGTCAATGGTATACGAATATTAGGAGATGATTCTGAGAAAGGAAAGGCCTTG
TTGGCAGTACTCCTGTTAAGCCATTAGTCTCTAAATTCCAGCTTTACTGTGAAGTTCTATAGAGTGTTAAATACAAATTTTCCTGTCTTG
CTTCACACAGTTCCTTAAAATCAGTTTTGAACTTTGGTCATAGAGTCTTCATATTTCAGTATTTGGTGGTCCCTATGACTTATACATAAC
TTTGTAAAAAGAAAAAAAAATTTTTTCTGATGCTTTGAATATAGTTTTGAAAGGAGTTTTGACTTTTTTCCCCTCATTCATCTCAGTATA
GAGTGCGCTATTTCACAATACGATTTTTGTCATTAAAATTACCATATTCTTTATTATATAACGTTAACTATTGAGTTGATCTGTTTAAAA
TATAAATCTCAAGTTAATTAAAAATAAGCTTTTCAAAAATGTATTATATTTATAACAAATATACTGTAAATAGAATAAAGACATGCTATT
CACTGTATAGCGTATTAGTATCTGTTGATTAGAAAGTCTGGTTTCAAAATATTTTTTTATTCAGAGAATGGGCATTTGGACATAAGAAAT
TTCAATTCAGCCCTGCTGCAGATAGAGAAATGGGAGCAAGGTTGTTTCAATGAATATCTCTTGTCATTGGAGAAGGAGGGAAGACAGGGT
GTAGGAGTGGGTGGCAGGGAGTACAAGAGCCAGGGTCAGTCAAGTCTGGAGCAGATGGGGTCCTTGTGCCATTGACAGCTACCATGGTTT
GTTCCAGTCTCAATCTCGGCACTAATCGGAGCAGACTGCACCAAAGTGGGGAGAGATCAAAAGACCCCGTTTTCAGACTGAAGATTCCAA
ACCTGTACTTGGAACAACTCTTCTTGAGAGATGGGTGGCTAGTCTGTGTGCCTCTCTGCAACTGCTGCTTATGCTTCTGGATCTTAAGTG
GGTCTCTGGCTTTTCAGCTCCTTCCACTCTGTGTCTTAGCAGGTGTGGGACAAGTTGGAGAGGAAGGTCACATTCTAAGGACACTCATTT
CCTTCTTGAGAGTTTAGGGCCATGGGCTTATAAAAAGTCTGAGGAGGAAAGACAAGAATGAGGAGGCATAATCACAGTGGTATCTCATAT
TTAAACCACTCAGCTGAATATTAAATTGAACCGATTGTTAAACAGACACTAATAAAAAAATTAAACTATATAAACCTACAACTGAATATA

>102567_102567_2_ZNF616-TRAPPC8_ZNF616_chr19_52633754_ENST00000597013_TRAPPC8_chr18_29511486_ENST00000283351_length(amino acids)=1381AA_BP=0
MRDPNNQLHVIKNLKIAVSNIVTQPPQPGAIRKLLNDVVSGSQPAEGLVANVITAGDYDLNISATTPWFESYRETFLQSMPALDHEFLNH
YLACMLVASSSEAEPVEQFSKLSQEQHRIQHNSDYSYPKWFIPNTLKYYVLLHDVSAGDEQRAESIYEEMKQKYGTQGCYLLKINSRTSN
RASDEQIPDPWSQYLQKNSIQNQESYEDGPCTITSNKNSDNNLLSLDGLDNEVKDGLPNNFRAHPLQLEQSSDPSNSIDGPDHLRSASSL
HETKKGNTGIIHGACLTLTDHDRIRQFIQEFTFRGLLPHIEKTIRQLNDQLISRKGLSRSLFSATKKWFSGSKVPEKSINDLKNTSGLLY
PPEAPELQIRKMADLCFLVQHYDLAYSCYHTAKKDFLNDQAMLYAAGALEMAAVSAFLQPGAPRPYPAHYMDTAIQTYRDICKNMVLAER
CVLLSAELLKSQSKYSEAAALLIRLTSEDSDLRSALLLEQAAHCFINMKSPMVRKYAFHMILAGHRFSKAGQKKHALRCYCQAMQVYKGK
GWSLAEDHINFTIGRQSYTLRQLDNAVSAFRHILINESKQSAAQQGAFLREYLYVYKNVSQLSPDGPLPQLPLPYINSSATRVFFGHDRR
PADGEKQAATHVSLDQEYDSESSQQWRELEEQVVSVVNKGVIPSNFHPTQYCLNSYSDNSRFPLAVVEEPITVEVAFRNPLKVLLLLTDL
SLLWKFHPKDFSGKDNEEVKQLVTSEPEMIGAEVISEFLINGEESKVARLKLFPHHIGELHILGVVYNLGTIQGSMTVDGIGALPGCHTG
KYSLSMSVRGKQDLEIQGPRLNNTKEEKTSVKYGPDRRLDPIITEEMPLLEVFFIHFPTGLLCGEIRKAYVEFVNVSKCPLTGLKVVSKR
PEFFTFGGNTAVLTPLSPSASENCSAYKTVVTDATSVCTALISSASSVDFGIGTGSQPEVIPVPLPDTVLLPGASVQLPMWLRGPDEEGV
HEINFLFYYESVKKQPKIRHRILRHTAIICTSRSLNVRATVCRSNSLENEEGRGGNMLVFVDVENTNTSEAGVKEFHIVQVSSSSKHWKL
QKSVNLSENKDTKLASREKGKFCFKAIRCEKEEAATQSSEKYTFADIIFGNEQIISSASPCADFFYRSLSSELKKPQAHLPVHTEKQSTE
DAVRLIQKCSEVDLNIVILWKAYVVEDSKQLILEGQHHVILRTIGKEAFSYPQKQEPPEMELLKFFRPENITVSSRPSVEQLSSLIKTSL
HYPESFNHPFHQKSLCLVPVTLLLSNCSKADVDVIVDLRHKTTSPEALEIHGSFTWLGQTQYKLQLKSQEIHSLQLKACFVHTGVYNLGT

--------------------------------------------------------------
>102567_102567_3_ZNF616-TRAPPC8_ZNF616_chr19_52633754_ENST00000600228_TRAPPC8_chr18_29511486_ENST00000283351_length(transcript)=6007nt_BP=274nt
CAGGGAAAGGCCTTATCGCTGTGTGTGTGTTTCAGTCTACGTGGATTAAACATTACTTCGCTCCGTCTGCCTGGATTAAACGTGCACTTT
GCAGTCCTCACTTCTCCGTACCAGTGATCTGGGGATCGCTACGGACCTTAAAATACCCATAGCCCCTTCGCCCCTGCAACAGGCACTTCT
CCCCACGTTTGATGTGTGAATAATTACATTGACTGAGAAAGAAACCCAGAAGAGGAAGAAGAGGAAGGAAAAGGAGTCAGTGATGGCTAC
TCAGTTCACATGAGAGATCCTAATAATCAACTTCACGTAATTAAAAATTTGAAGATAGCAGTAAGCAACATTGTCACCCAGCCACCTCAG
CCTGGAGCCATCCGGAAGCTTTTGAATGATGTTGTTTCTGGCAGTCAGCCTGCAGAAGGATTAGTAGCTAATGTGATTACAGCAGGAGAT
TATGACCTTAACATCAGTGCCACTACTCCATGGTTTGAGTCTTACAGAGAAACCTTTCTTCAGTCGATGCCAGCATTGGATCATGAATTT
CTGAACCACTATTTAGCATGTATGTTGGTAGCGTCATCTAGTGAAGCTGAACCTGTGGAACAGTTTTCAAAGTTGTCACAAGAACAGCAT
CGAATTCAGCACAACAGTGATTATTCCTACCCCAAGTGGTTTATACCAAATACACTTAAATACTATGTACTTTTACATGATGTAAGTGCA
GGAGATGAACAGAGAGCTGAATCAATTTATGAAGAAATGAAACAGAAATATGGAACTCAGGGTTGCTATTTACTTAAAATTAATTCTCGA
ACATCTAATCGAGCATCAGATGAACAGATACCAGATCCTTGGAGTCAGTATCTCCAGAAAAATAGTATTCAAAACCAGGAATCATATGAA
GATGGCCCTTGTACTATAACTTCAAATAAGAATTCTGATAATAACTTGCTTTCATTGGATGGATTAGATAACGAAGTCAAAGATGGCTTA
CCAAATAACTTTAGAGCTCACCCACTTCAGTTGGAGCAATCCAGTGACCCTTCTAACAGTATTGATGGCCCAGATCATCTAAGATCTGCT
TCATCGTTACATGAAACAAAGAAAGGAAATACTGGAATAATTCATGGTGCATGTTTAACACTTACTGATCATGATAGAATTCGACAGTTT
ATACAAGAGTTCACATTTCGGGGCCTTTTGCCACATATAGAGAAAACAATTAGGCAATTAAACGATCAGCTAATATCAAGAAAAGGTTTG
AGTCGATCTCTATTTTCTGCAACTAAAAAATGGTTTAGTGGCAGTAAAGTTCCAGAAAAGAGCATTAATGACCTGAAAAATACATCTGGC
TTGCTGTATCCGCCGGAAGCACCAGAACTTCAAATCAGGAAAATGGCTGACTTATGTTTTTTGGTGCAGCATTATGATTTGGCTTACAGT
TGCTATCATACTGCAAAGAAAGATTTTCTTAATGATCAAGCAATGCTTTATGCAGCTGGTGCCTTGGAAATGGCAGCAGTGTCTGCTTTT
CTTCAACCAGGAGCACCTAGGCCATATCCTGCTCATTACATGGATACAGCAATTCAGACATACAGAGATATCTGCAAGAATATGGTGTTG
GCTGAAAGATGTGTGTTGCTTAGTGCTGAACTTTTAAAAAGCCAAAGCAAATATTCAGAGGCTGCAGCTCTCCTAATACGGTTGACCAGT
GAGGATTCTGATCTTCGAAGTGCACTTCTTTTGGAACAGGCAGCACATTGCTTTATAAACATGAAAAGTCCCATGGTTAGAAAATATGCA
TTTCATATGATATTGGCAGGCCATCGATTTAGTAAAGCAGGGCAGAAAAAGCATGCTTTACGCTGTTATTGTCAAGCCATGCAAGTTTAC
AAAGGAAAAGGCTGGTCTCTTGCAGAGGATCACATTAATTTCACTATTGGGCGCCAGTCCTATACTCTTAGACAGCTGGATAATGCTGTG
TCTGCTTTTAGGCATATTCTAATTAATGAAAGTAAACAATCTGCTGCTCAACAGGGGGCTTTCCTCAGAGAATATCTTTATGTTTACAAG
AATGTAAGTCAGCTGTCACCAGATGGTCCTTTGCCACAGCTTCCTTTACCGTATATTAACAGTTCAGCAACACGGGTTTTTTTTGGCCAT
GACAGACGACCAGCGGATGGTGAAAAACAAGCAGCTACTCATGTAAGTCTTGATCAAGAATATGATTCTGAATCCTCTCAGCAGTGGCGA
GAACTTGAGGAACAAGTTGTTTCTGTGGTTAACAAAGGAGTAATTCCATCCAATTTTCATCCCACACAATACTGTTTGAACAGTTACTCA
GATAATTCAAGATTTCCACTTGCAGTTGTAGAAGAACCAATTACAGTGGAAGTGGCTTTTAGAAACCCTTTGAAAGTTCTACTTTTGTTG
ACTGATTTGTCATTGCTTTGGAAGTTTCATCCTAAAGATTTCAGTGGAAAGGATAATGAAGAAGTTAAACAACTAGTTACAAGTGAACCT
GAAATGATTGGAGCTGAAGTTATTTCAGAGTTCTTAATTAATGGCGAAGAATCAAAAGTGGCAAGACTAAAGCTCTTTCCCCATCACATA
GGGGAGCTGCATATTCTGGGAGTTGTTTATAATCTTGGCACTATTCAGGGCTCTATGACAGTAGATGGCATTGGTGCTCTTCCCGGATGT
CACACAGGAAAATATTCCTTGAGTATGTCAGTCCGAGGGAAGCAGGATTTAGAAATTCAAGGTCCTCGACTTAACAACACAAAAGAAGAG
AAAACATCTGTTAAATATGGCCCTGATCGACGTTTAGATCCCATAATCACAGAAGAAATGCCACTGTTGGAGGTGTTCTTTATACATTTT
CCTACAGGGCTTCTCTGTGGAGAAATCCGAAAAGCATATGTAGAATTTGTCAATGTCAGCAAATGTCCACTTACTGGATTGAAGGTTGTT
TCTAAACGTCCAGAGTTCTTTACTTTCGGTGGTAATACTGCTGTTCTAACACCACTAAGTCCCTCAGCTTCTGAGAATTGTAGTGCTTAC
AAGACTGTTGTGACAGATGCTACCTCTGTGTGTACAGCACTCATATCATCAGCTTCTTCTGTAGACTTTGGCATTGGCACAGGAAGTCAA
CCAGAGGTGATTCCTGTTCCCCTTCCTGACACTGTTCTTCTACCCGGAGCCTCAGTGCAGCTGCCAATGTGGTTACGTGGGCCTGATGAA
GAAGGTGTCCATGAAATTAACTTTTTGTTTTACTATGAAAGTGTCAAAAAGCAGCCAAAAATACGGCACAGAATATTAAGACACACTGCA
ATTATTTGTACCAGTCGGTCTTTAAATGTACGGGCCACTGTCTGCAGAAGTAATTCTCTTGAAAATGAAGAAGGCAGAGGAGGCAATATG
CTAGTCTTTGTGGATGTGGAAAATACCAATACTAGTGAAGCAGGCGTTAAGGAATTCCACATAGTGCAAGTATCAAGTAGTAGCAAACAC
TGGAAGTTACAGAAATCTGTAAATCTTTCTGAAAACAAAGATACCAAACTTGCCAGTAGGGAGAAGGGAAAGTTTTGCTTTAAGGCAATA
AGATGTGAGAAAGAAGAAGCGGCCACACAGTCCTCTGAAAAATATACCTTTGCAGATATCATCTTTGGAAATGAACAGATAATAAGTTCA
GCAAGCCCATGTGCAGACTTCTTTTATCGAAGTTTATCTTCTGAATTGAAAAAACCACAAGCTCACTTGCCTGTGCATACAGAAAAACAG
TCAACAGAGGATGCTGTGAGATTGATTCAAAAATGCAGTGAGGTAGATTTGAATATTGTCATATTATGGAAGGCATACGTTGTGGAAGAC
AGTAAACAGCTTATTTTGGAAGGTCAACATCATGTTATTCTTCGCACTATAGGAAAAGAAGCCTTTTCATATCCTCAGAAACAGGAGCCA
CCAGAAATGGAACTATTGAAATTTTTCAGGCCAGAAAACATTACAGTTTCCTCAAGGCCATCAGTAGAGCAGCTTTCTAGTCTCATTAAA
ACGAGTCTTCACTACCCAGAATCATTTAATCATCCATTTCATCAAAAAAGCCTTTGTTTAGTACCAGTCACTCTTTTACTTTCCAATTGT
TCTAAGGCTGATGTAGATGTCATAGTTGATCTTCGGCATAAAACAACAAGTCCAGAAGCACTGGAAATCCATGGATCATTCACATGGCTT
GGACAAACACAGTATAAACTTCAACTTAAAAGCCAGGAGATTCACAGTCTGCAGCTGAAAGCATGCTTTGTTCATACAGGTGTTTATAAC
CTTGGAACTCCTAGGGTATTTGCCAAGTTATCGGACCAAGTTACAGTGTTTGAAACAAGTCAGCAGAATTCCATGCCTGCCCTGATCATC
ATCAGTAATGTGTGACAACTTGGAAATTTGTACTGAAATCCACAATAATCAGTTTTTGCTGGATGGGTTTTACAGCAGTATTTGATATAC
CTAACTTGTTATGGAGGTTGATTGATATCTGATCCCTGCAAAATACTTTGACTTGTCATTTTGTTGATGATGCAAAGCACGTTGGACTGA
GAATACTTAACATTCTTTTTCTGTATTTCTTTAAACCCTGAGAATAATTTACATGCTCATAATACAGGATATCAGCATATTTGTGCACCT
TATTAAGCCCCATCTTAAGAAAACACAAAGTCTAAGTCTGCTGTTACAACTTGTCAATGGTATACGAATATTAGGAGATGATTCTGAGAA
AGGAAAGGCCTTGTTGGCAGTACTCCTGTTAAGCCATTAGTCTCTAAATTCCAGCTTTACTGTGAAGTTCTATAGAGTGTTAAATACAAA
TTTTCCTGTCTTGCTTCACACAGTTCCTTAAAATCAGTTTTGAACTTTGGTCATAGAGTCTTCATATTTCAGTATTTGGTGGTCCCTATG
ACTTATACATAACTTTGTAAAAAGAAAAAAAAATTTTTTCTGATGCTTTGAATATAGTTTTGAAAGGAGTTTTGACTTTTTTCCCCTCAT
TCATCTCAGTATAGAGTGCGCTATTTCACAATACGATTTTTGTCATTAAAATTACCATATTCTTTATTATATAACGTTAACTATTGAGTT
GATCTGTTTAAAATATAAATCTCAAGTTAATTAAAAATAAGCTTTTCAAAAATGTATTATATTTATAACAAATATACTGTAAATAGAATA
AAGACATGCTATTCACTGTATAGCGTATTAGTATCTGTTGATTAGAAAGTCTGGTTTCAAAATATTTTTTTATTCAGAGAATGGGCATTT
GGACATAAGAAATTTCAATTCAGCCCTGCTGCAGATAGAGAAATGGGAGCAAGGTTGTTTCAATGAATATCTCTTGTCATTGGAGAAGGA
GGGAAGACAGGGTGTAGGAGTGGGTGGCAGGGAGTACAAGAGCCAGGGTCAGTCAAGTCTGGAGCAGATGGGGTCCTTGTGCCATTGACA
GCTACCATGGTTTGTTCCAGTCTCAATCTCGGCACTAATCGGAGCAGACTGCACCAAAGTGGGGAGAGATCAAAAGACCCCGTTTTCAGA
CTGAAGATTCCAAACCTGTACTTGGAACAACTCTTCTTGAGAGATGGGTGGCTAGTCTGTGTGCCTCTCTGCAACTGCTGCTTATGCTTC
TGGATCTTAAGTGGGTCTCTGGCTTTTCAGCTCCTTCCACTCTGTGTCTTAGCAGGTGTGGGACAAGTTGGAGAGGAAGGTCACATTCTA
AGGACACTCATTTCCTTCTTGAGAGTTTAGGGCCATGGGCTTATAAAAAGTCTGAGGAGGAAAGACAAGAATGAGGAGGCATAATCACAG
TGGTATCTCATATTTAAACCACTCAGCTGAATATTAAATTGAACCGATTGTTAAACAGACACTAATAAAAAAATTAAACTATATAAACCT

>102567_102567_3_ZNF616-TRAPPC8_ZNF616_chr19_52633754_ENST00000600228_TRAPPC8_chr18_29511486_ENST00000283351_length(amino acids)=1381AA_BP=0
MRDPNNQLHVIKNLKIAVSNIVTQPPQPGAIRKLLNDVVSGSQPAEGLVANVITAGDYDLNISATTPWFESYRETFLQSMPALDHEFLNH
YLACMLVASSSEAEPVEQFSKLSQEQHRIQHNSDYSYPKWFIPNTLKYYVLLHDVSAGDEQRAESIYEEMKQKYGTQGCYLLKINSRTSN
RASDEQIPDPWSQYLQKNSIQNQESYEDGPCTITSNKNSDNNLLSLDGLDNEVKDGLPNNFRAHPLQLEQSSDPSNSIDGPDHLRSASSL
HETKKGNTGIIHGACLTLTDHDRIRQFIQEFTFRGLLPHIEKTIRQLNDQLISRKGLSRSLFSATKKWFSGSKVPEKSINDLKNTSGLLY
PPEAPELQIRKMADLCFLVQHYDLAYSCYHTAKKDFLNDQAMLYAAGALEMAAVSAFLQPGAPRPYPAHYMDTAIQTYRDICKNMVLAER
CVLLSAELLKSQSKYSEAAALLIRLTSEDSDLRSALLLEQAAHCFINMKSPMVRKYAFHMILAGHRFSKAGQKKHALRCYCQAMQVYKGK
GWSLAEDHINFTIGRQSYTLRQLDNAVSAFRHILINESKQSAAQQGAFLREYLYVYKNVSQLSPDGPLPQLPLPYINSSATRVFFGHDRR
PADGEKQAATHVSLDQEYDSESSQQWRELEEQVVSVVNKGVIPSNFHPTQYCLNSYSDNSRFPLAVVEEPITVEVAFRNPLKVLLLLTDL
SLLWKFHPKDFSGKDNEEVKQLVTSEPEMIGAEVISEFLINGEESKVARLKLFPHHIGELHILGVVYNLGTIQGSMTVDGIGALPGCHTG
KYSLSMSVRGKQDLEIQGPRLNNTKEEKTSVKYGPDRRLDPIITEEMPLLEVFFIHFPTGLLCGEIRKAYVEFVNVSKCPLTGLKVVSKR
PEFFTFGGNTAVLTPLSPSASENCSAYKTVVTDATSVCTALISSASSVDFGIGTGSQPEVIPVPLPDTVLLPGASVQLPMWLRGPDEEGV
HEINFLFYYESVKKQPKIRHRILRHTAIICTSRSLNVRATVCRSNSLENEEGRGGNMLVFVDVENTNTSEAGVKEFHIVQVSSSSKHWKL
QKSVNLSENKDTKLASREKGKFCFKAIRCEKEEAATQSSEKYTFADIIFGNEQIISSASPCADFFYRSLSSELKKPQAHLPVHTEKQSTE
DAVRLIQKCSEVDLNIVILWKAYVVEDSKQLILEGQHHVILRTIGKEAFSYPQKQEPPEMELLKFFRPENITVSSRPSVEQLSSLIKTSL
HYPESFNHPFHQKSLCLVPVTLLLSNCSKADVDVIVDLRHKTTSPEALEIHGSFTWLGQTQYKLQLKSQEIHSLQLKACFVHTGVYNLGT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZNF616-TRAPPC8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF616-TRAPPC8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF616-TRAPPC8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource