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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ZNF626-SBF1 (FusionGDB2 ID:102593)

Fusion Gene Summary for ZNF626-SBF1

Fusion gene summary

Fusion gene information	Fusion gene name: ZNF626-SBF1
	Fusion gene ID: 102593
		Hgene	Tgene
	Gene symbol	ZNF626	SBF1
	Gene ID	199777	6305
	Gene name	zinc finger protein 626	SET binding factor 1
	Synonyms	-	CMT4B3\|DENND7A\|MTMR5
	Cytomap	19p12	22q13.33
	Type of gene	protein-coding	protein-coding
	Description	zinc finger protein 626CTC-513N18.7	myotubularin-related protein 5DENN/MADD domain containing 7Ainactive phosphatidylinositol 3-phosphatase 5
	Modification date	20200313	20200328
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000291750, ENST00000601440,	ENST00000476293, ENST00000348911, ENST00000380817, ENST00000390679,
Fusion gene scores	* DoF score	7 X 4 X 5=140	6 X 5 X 6=180
	# samples	8	6
	** MAII score	log2(8/140*10)=-0.807354922057604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/180*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ZNF626 [Title/Abstract] AND SBF1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ZNF626(20844249)-SBF1(50887079), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across ZNF626 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SBF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-09-1670	ZNF626	chr19	20844249	-	SBF1	chr22	50887079	-

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Fusion Gene ORF analysis for ZNF626-SBF1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000291750	ENST00000476293	ZNF626	chr19	20844249	-	SBF1	chr22	50887079	-
5CDS-intron	ENST00000601440	ENST00000476293	ZNF626	chr19	20844249	-	SBF1	chr22	50887079	-
In-frame	ENST00000291750	ENST00000348911	ZNF626	chr19	20844249	-	SBF1	chr22	50887079	-
In-frame	ENST00000291750	ENST00000380817	ZNF626	chr19	20844249	-	SBF1	chr22	50887079	-
In-frame	ENST00000291750	ENST00000390679	ZNF626	chr19	20844249	-	SBF1	chr22	50887079	-
In-frame	ENST00000601440	ENST00000348911	ZNF626	chr19	20844249	-	SBF1	chr22	50887079	-
In-frame	ENST00000601440	ENST00000380817	ZNF626	chr19	20844249	-	SBF1	chr22	50887079	-
In-frame	ENST00000601440	ENST00000390679	ZNF626	chr19	20844249	-	SBF1	chr22	50887079	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000601440	ZNF626	chr19	20844249	-	ENST00000380817	SBF1	chr22	50887079	-	2931	150	147	788	213
ENST00000601440	ZNF626	chr19	20844249	-	ENST00000348911	SBF1	chr22	50887079	-	1125	150	147	788	213
ENST00000601440	ZNF626	chr19	20844249	-	ENST00000390679	SBF1	chr22	50887079	-	789	150	147	788	213
ENST00000291750	ZNF626	chr19	20844249	-	ENST00000380817	SBF1	chr22	50887079	-	2934	153	150	791	213
ENST00000291750	ZNF626	chr19	20844249	-	ENST00000348911	SBF1	chr22	50887079	-	1128	153	150	791	213
ENST00000291750	ZNF626	chr19	20844249	-	ENST00000390679	SBF1	chr22	50887079	-	792	153	150	791	213

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000601440	ENST00000380817	ZNF626	chr19	20844249	-	SBF1	chr22	50887079	-	0.13563699	0.86436296
ENST00000601440	ENST00000348911	ZNF626	chr19	20844249	-	SBF1	chr22	50887079	-	0.36374238	0.6362576
ENST00000601440	ENST00000390679	ZNF626	chr19	20844249	-	SBF1	chr22	50887079	-	0.4365557	0.56344426
ENST00000291750	ENST00000380817	ZNF626	chr19	20844249	-	SBF1	chr22	50887079	-	0.13604096	0.8639591
ENST00000291750	ENST00000348911	ZNF626	chr19	20844249	-	SBF1	chr22	50887079	-	0.35336614	0.64663386
ENST00000291750	ENST00000390679	ZNF626	chr19	20844249	-	SBF1	chr22	50887079	-	0.42131847	0.5786815

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Fusion Genomic Features for ZNF626-SBF1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF626-SBF1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:20844249/chr22:50887079)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SBF1

chr19:20844249

chr22:50887079

ENST00000380817

1762_1866

1681

1894.0

Domain

Tgene

SBF1

chr19:20844249

chr22:50887079

ENST00000390679

1762_1866

1655

1868.0

Domain

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ZNF626

chr19:20844249

chr22:50887079

ENST00000291750

4_75

93.0

Domain

KRAB

Hgene

ZNF626

chr19:20844249

chr22:50887079

ENST00000601440

4_75

529.0

Domain

KRAB

Hgene

ZNF626

chr19:20844249

chr22:50887079

ENST00000291750

173_195

93.0

Zinc finger

C2H2-type 1%3B degenerate

Hgene

ZNF626

chr19:20844249

chr22:50887079

ENST00000291750

201_223

93.0

Zinc finger

C2H2-type 2

Hgene

ZNF626

chr19:20844249

chr22:50887079

ENST00000291750

229_251

93.0

Zinc finger

C2H2-type 3

Hgene

ZNF626

chr19:20844249

chr22:50887079

ENST00000291750

257_279

93.0

Zinc finger

C2H2-type 4

Hgene

ZNF626

chr19:20844249

chr22:50887079

ENST00000291750

285_307

93.0

Zinc finger

C2H2-type 5

Hgene

ZNF626

chr19:20844249

chr22:50887079

ENST00000291750

313_335

93.0

Zinc finger

C2H2-type 6

Hgene

ZNF626

chr19:20844249

chr22:50887079

ENST00000291750

341_363

93.0

Zinc finger

C2H2-type 7

Hgene

ZNF626

chr19:20844249

chr22:50887079

ENST00000291750

369_391

93.0

Zinc finger

C2H2-type 8

Hgene

ZNF626

chr19:20844249

chr22:50887079

ENST00000291750

397_419

93.0

Zinc finger

C2H2-type 9

Hgene

ZNF626

chr19:20844249

chr22:50887079

ENST00000291750

425_447

93.0

Zinc finger

C2H2-type 10

Hgene

ZNF626

chr19:20844249

chr22:50887079

ENST00000291750

453_475

93.0

Zinc finger

C2H2-type 11

Hgene

ZNF626

chr19:20844249

chr22:50887079

ENST00000291750

481_503

93.0

Zinc finger

C2H2-type 12%3B degenerate

Hgene

ZNF626

chr19:20844249

chr22:50887079

ENST00000601440

173_195

529.0

Zinc finger

C2H2-type 1%3B degenerate

Hgene

ZNF626

chr19:20844249

chr22:50887079

ENST00000601440

201_223

529.0

Zinc finger

C2H2-type 2

Hgene

ZNF626

chr19:20844249

chr22:50887079

ENST00000601440

229_251

529.0

Zinc finger

C2H2-type 3

Hgene

ZNF626

chr19:20844249

chr22:50887079

ENST00000601440

257_279

529.0

Zinc finger

C2H2-type 4

Hgene

ZNF626

chr19:20844249

chr22:50887079

ENST00000601440

285_307

529.0

Zinc finger

C2H2-type 5

Hgene

ZNF626

chr19:20844249

chr22:50887079

ENST00000601440

313_335

529.0

Zinc finger

C2H2-type 6

Hgene

ZNF626

chr19:20844249

chr22:50887079

ENST00000601440

341_363

529.0

Zinc finger

C2H2-type 7

Hgene

ZNF626

chr19:20844249

chr22:50887079

ENST00000601440

369_391

529.0

Zinc finger

C2H2-type 8

Hgene

ZNF626

chr19:20844249

chr22:50887079

ENST00000601440

397_419

529.0

Zinc finger

C2H2-type 9

Hgene

ZNF626

chr19:20844249

chr22:50887079

ENST00000601440

425_447

529.0

Zinc finger

C2H2-type 10

Hgene

ZNF626

chr19:20844249

chr22:50887079

ENST00000601440

453_475

529.0

Zinc finger

C2H2-type 11

Hgene

ZNF626

chr19:20844249

chr22:50887079

ENST00000601440

481_503

529.0

Zinc finger

C2H2-type 12%3B degenerate

Tgene

SBF1

chr19:20844249

chr22:50887079

ENST00000380817

1121_1597

1681

1894.0

Domain

Myotubularin phosphatase

Tgene

SBF1

chr19:20844249

chr22:50887079

ENST00000380817

204_337

1681

1894.0

Domain

cDENN

Tgene

SBF1

chr19:20844249

chr22:50887079

ENST00000380817

339_440

1681

1894.0

Domain

dDENN

Tgene

SBF1

chr19:20844249

chr22:50887079

ENST00000380817

7_185

1681

1894.0

Domain

uDENN

Tgene

SBF1

chr19:20844249

chr22:50887079

ENST00000380817

881_969

1681

1894.0

Domain

GRAM

Tgene

SBF1

chr19:20844249

chr22:50887079

ENST00000390679

1121_1597

1655

1868.0

Domain

Myotubularin phosphatase

Tgene

SBF1

chr19:20844249

chr22:50887079

ENST00000390679

204_337

1655

1868.0

Domain

cDENN

Tgene

SBF1

chr19:20844249

chr22:50887079

ENST00000390679

339_440

1655

1868.0

Domain

dDENN

Tgene

SBF1

chr19:20844249

chr22:50887079

ENST00000390679

7_185

1655

1868.0

Domain

uDENN

Tgene

SBF1

chr19:20844249

chr22:50887079

ENST00000390679

881_969

1655

1868.0

Domain

GRAM

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Fusion Gene Sequence for ZNF626-SBF1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>102593_102593_1_ZNF626-SBF1_ZNF626_chr19_20844249_ENST00000291750_SBF1_chr22_50887079_ENST00000348911_length(transcript)=1128nt_BP=153nt
GGTTTCCGGGTTTGGTGCGGCCTTTGTCTCTCGCTGCAGTCAGAGCTCCAGGTCTGGTTCTTCTCCTAAAGGCCCAGGCTGTGTGGCCCC
GTGTCCTGCAGGTATTGGGAGATCCACAGCTAAGACACCGGGACCTCCTGGAAGCCAAAAATGGAGCTGCAGAGGCTGGAGACAGAGTTG
GGCCAACCCGCTGAGCGCTGGAAGGACACCTGGGACCGGGTGAAGGCTGCACAGCGCCTCGAGGGCCGGCCAGACGGCCGTGGCACCCCT
AGCTCCCTCCTTGTGTCCACCGCACCCCACCACCGTCGCTCGCTGGGTGTGTACCTGCAGGAGGGGCCCGTGGGCTCCACCCTGAGCCTC
AGCCTGGACAGCGACCAGAGTAGTGGCTCAACCACATCCGGCTCCCGTCAGGCTGCCCGCCGCAGCACCAGCACCCTGTACAGCCAGTTC
CAGACAGCAGAGAGTGAGAACAGGTCCTACGAGGGCACTCTGTACAAGAAGGGGGCCTTCATGAAGCCTTGGAAGGCCCGCTGGTTCGTG
CTGGACAAGACCAAGCACCAGCTGCGCTACTACGACCACCGTGTGGACACAGAGTGCAAGGGTGTCATCGACTTGGCGGAGGTGGAGGCT
GTGGCACCTGGCACGCCCACTATGGGTGCCCCTAAGACTGTGGACGAGAAGGCCTTCTTTGACGTGAAGACAACGCGTCGCGTTTACAAC
TTCTGTGCCCAGGACGTGCCCTCGGCCCAGCAGTGGGTGGACCGGATCCAGAGCTGCCTGTCGGACGCCTGAGCCTCCCAGCCCTGCCCG
GCTGCTCTGCTTCCGGTCGTTACCGACCACTAGGGGTGGGCAGGGCCGCCCCGGCCATGTTTACAGCCCCGGCCCTCGACAGTATTGAGG
CCCCGAGCCCCCAGCACTTGTGTGTACAGCCCCCGTCCCCGCCCCGCCCCGCCCGGCCGGCCCTAACTTATTTTGGCGTCACAGCTGAGC
ACCGTGCCGGGAGGTGGCCAAGGTACAGCCCGCAATGGGCCTGTAAATAGTCCGGCCCCGTCAGCGTGTGCTGGTCCAGCCAGCGGCTGC

>102593_102593_1_ZNF626-SBF1_ZNF626_chr19_20844249_ENST00000291750_SBF1_chr22_50887079_ENST00000348911_length(amino acids)=213AA_BP=1
MELQRLETELGQPAERWKDTWDRVKAAQRLEGRPDGRGTPSSLLVSTAPHHRRSLGVYLQEGPVGSTLSLSLDSDQSSGSTTSGSRQAAR
RSTSTLYSQFQTAESENRSYEGTLYKKGAFMKPWKARWFVLDKTKHQLRYYDHRVDTECKGVIDLAEVEAVAPGTPTMGAPKTVDEKAFF

--------------------------------------------------------------
>102593_102593_2_ZNF626-SBF1_ZNF626_chr19_20844249_ENST00000291750_SBF1_chr22_50887079_ENST00000380817_length(transcript)=2934nt_BP=153nt
GGTTTCCGGGTTTGGTGCGGCCTTTGTCTCTCGCTGCAGTCAGAGCTCCAGGTCTGGTTCTTCTCCTAAAGGCCCAGGCTGTGTGGCCCC
GTGTCCTGCAGGTATTGGGAGATCCACAGCTAAGACACCGGGACCTCCTGGAAGCCAAAAATGGAGCTGCAGAGGCTGGAGACAGAGTTG
GGCCAACCCGCTGAGCGCTGGAAGGACACCTGGGACCGGGTGAAGGCTGCACAGCGCCTCGAGGGCCGGCCAGACGGCCGTGGCACCCCT
AGCTCCCTCCTTGTGTCCACCGCACCCCACCACCGTCGCTCGCTGGGTGTGTACCTGCAGGAGGGGCCCGTGGGCTCCACCCTGAGCCTC
AGCCTGGACAGCGACCAGAGTAGTGGCTCAACCACATCCGGCTCCCGTCAGGCTGCCCGCCGCAGCACCAGCACCCTGTACAGCCAGTTC
CAGACAGCAGAGAGTGAGAACAGGTCCTACGAGGGCACTCTGTACAAGAAGGGGGCCTTCATGAAGCCTTGGAAGGCCCGCTGGTTCGTG
CTGGACAAGACCAAGCACCAGCTGCGCTACTACGACCACCGTGTGGACACAGAGTGCAAGGGTGTCATCGACTTGGCGGAGGTGGAGGCT
GTGGCACCTGGCACGCCCACTATGGGTGCCCCTAAGACTGTGGACGAGAAGGCCTTCTTTGACGTGAAGACAACGCGTCGCGTTTACAAC
TTCTGTGCCCAGGACGTGCCCTCGGCCCAGCAGTGGGTGGACCGGATCCAGAGCTGCCTGTCGGACGCCTGAGCCTCCCAGCCCTGCCCG
GCTGCTCTGCTTCCGGTCGTTACCGACCACTAGGGGTGGGCAGGGCCGCCCCGGCCATGTTTACAGCCCCGGCCCTCGACAGTATTGAGG
CCCCGAGCCCCCAGCACTTGTGTGTACAGCCCCCGTCCCCGCCCCGCCCCGCCCGGCCGGCCCTAACTTATTTTGGCGTCACAGCTGAGC
ACCGTGCCGGGAGGTGGCCAAGGTACAGCCCGCAATGGGCCTGTAAATAGTCCGGCCCCGTCAGCGTGTGCTGGTCCAGCCAGCGGCTGC
AGGCGAGTTTCTAGAACCAGAGTCTATATAAAGAGAGAACTAACGCCACGCTCCTGTGCCTGCCTTCCCCACTCCCCGGCTGCCTGCTCT
CGGCCTACCCAGAGGGTCCCATCTGCCCCTATCCAGGCCCACCTGGCGGGAGGTTGGCATCTTTCTCGTGAGCCTCTCCTGGTGCCTGGG
TCCACCCAGCTCGGCCTGCATGTCCCTGGGAGTGACTTTGCTCTGGGGGCGGATCGAGCAGGAGGCTTCACTGGGGACTTGCTTGATTCC
CTCCACGCCTCAGGGCTGGTCTAGGGGCCGGCACGGCTGGAGAGGAAGCCCCCATCCCTACCCAGGGGATGCAGAAGCTGACCTCACAGA
GGCTTGGGGGTGAAAGGGTGGGTGGTCATTTGACCCCAGAAGGCTGTTGCAGGTCCAGAGGACACTTGAGGTGGACGTCAGTTTCTGGCT
AGACCCGAGCTGAAGGGATGGAGGCCGGAGGCGGGGGGGGGGGGGGGACAGTGGGCTCCCAGGGGAATGCAGGTTGACCACATCTGGCTC
CTGCCAGGCAACGAGCAGCATCTGGCAGAGTAAGGGGCCAACGCCCATGGGGGATGGACCCTCTCAGTTCTTGGGAATTCTGCCCCAAAA
GTCCTTTCCCTGGGGTCTCAGAGGGCCCCCGTCCTTCCCTTCTTGGTGTCACTGTGGCCCCTCACTGCTCTTTTCCTATTCAAACCTGAG
TCCCACCAGGCCCAGGGCTTCACCTGCTGAGCTGTTGTGTCCTTGCCTGTGACGAGGCCTGGCCAGGGGTGCAGGAGCAGAAGGTGGGGA
GGGTTATAGACGCTGCAAAGGCCAAGAGAACATCTGAGAGTGGCAGCTGGTGACCTGGCCAGAGGGGCTGGTGAGGGGCAGAGAACCTGG
CTAGAGGCTGGGTCCCTCAGGTGGTCCTCTCAGGTGGGAGGCGAGCAGCAGGTGTGGGTGAGGGGAAGGTTCTGATGACAGCTGCAGAGG
CAGGGCCCAGTGCTGGCAGGTGGGGGGCCAAGACCCTCCCCTGGTGGGACGTTGAAGCCAAGGATGGCCTTGGACCCTGTCAGGCCCAGC
ATGGTCCCGCCACCTCCCCCACCCCACAGGTGGTGTTGGGACACCTGGGCGAGATGTGAGGGTGGGCTCACTTGAGCCACTGAAACCAGC
CAGGTCTTCCCTCAGGCCGGACAGATGGCGCCTGACCGAAGTTCCTGGCACCTGGAAAACCCACAGGTCAGAGTAAGGGGAGAAAGGACC
CTGCCCTCCCTGTTCCACGTCTGTGGGGGGAGAGGACAAATGCCAGGCACAGGGTAGGCGGCGAGAACAAGGCACTCAATGTGTAGCTGG
GGCAGAGACTCGGCCTCTGGGGAGCTGAGCGGGTTCCCTCCACCCCCAACCGTGGTGGAAAGACAAGCTCGCTGGGGCGGGGTGGGGGTC
TGGTCTCCACCTGCCCCTCCCACTCAGCCACTGAGGACAAGGTGGGGCCCAGGCTTCTGGGAGGGGGAGCTGGCACAAAAGGAAGTCCTG
GGGTTGATGTGTTTGAGCGTTAGGCGAAGTGGTTCCCCCCATCCCCCAAACGGAAAAATGTCAGTATTTGCTAAGCTGTAGAGACCTGAT
GCCGTGATGTGGCCTGTTCCGCCTCCACCCATTACACGGGGATAACGCTGGGGGGTGGCGGGCCCACAAAAGAGGTGCTGGAGGAGACTC
TCCCACCCCTGGCCGGGCCGGGGCTTTGGGGCCGGAAGGTTCACAGTACGCGGTTTGTCCGAACGTCACGGCTTTTATTGGGAGTTGGGG

>102593_102593_2_ZNF626-SBF1_ZNF626_chr19_20844249_ENST00000291750_SBF1_chr22_50887079_ENST00000380817_length(amino acids)=213AA_BP=1
MELQRLETELGQPAERWKDTWDRVKAAQRLEGRPDGRGTPSSLLVSTAPHHRRSLGVYLQEGPVGSTLSLSLDSDQSSGSTTSGSRQAAR
RSTSTLYSQFQTAESENRSYEGTLYKKGAFMKPWKARWFVLDKTKHQLRYYDHRVDTECKGVIDLAEVEAVAPGTPTMGAPKTVDEKAFF

--------------------------------------------------------------
>102593_102593_3_ZNF626-SBF1_ZNF626_chr19_20844249_ENST00000291750_SBF1_chr22_50887079_ENST00000390679_length(transcript)=792nt_BP=153nt
GGTTTCCGGGTTTGGTGCGGCCTTTGTCTCTCGCTGCAGTCAGAGCTCCAGGTCTGGTTCTTCTCCTAAAGGCCCAGGCTGTGTGGCCCC
GTGTCCTGCAGGTATTGGGAGATCCACAGCTAAGACACCGGGACCTCCTGGAAGCCAAAAATGGAGCTGCAGAGGCTGGAGACAGAGTTG
GGCCAACCCGCTGAGCGCTGGAAGGACACCTGGGACCGGGTGAAGGCTGCACAGCGCCTCGAGGGCCGGCCAGACGGCCGTGGCACCCCT
AGCTCCCTCCTTGTGTCCACCGCACCCCACCACCGTCGCTCGCTGGGTGTGTACCTGCAGGAGGGGCCCGTGGGCTCCACCCTGAGCCTC
AGCCTGGACAGCGACCAGAGTAGTGGCTCAACCACATCCGGCTCCCGTCAGGCTGCCCGCCGCAGCACCAGCACCCTGTACAGCCAGTTC
CAGACAGCAGAGAGTGAGAACAGGTCCTACGAGGGCACTCTGTACAAGAAGGGGGCCTTCATGAAGCCTTGGAAGGCCCGCTGGTTCGTG
CTGGACAAGACCAAGCACCAGCTGCGCTACTACGACCACCGTGTGGACACAGAGTGCAAGGGTGTCATCGACTTGGCGGAGGTGGAGGCT
GTGGCACCTGGCACGCCCACTATGGGTGCCCCTAAGACTGTGGACGAGAAGGCCTTCTTTGACGTGAAGACAACGCGTCGCGTTTACAAC

>102593_102593_3_ZNF626-SBF1_ZNF626_chr19_20844249_ENST00000291750_SBF1_chr22_50887079_ENST00000390679_length(amino acids)=213AA_BP=1
MELQRLETELGQPAERWKDTWDRVKAAQRLEGRPDGRGTPSSLLVSTAPHHRRSLGVYLQEGPVGSTLSLSLDSDQSSGSTTSGSRQAAR
RSTSTLYSQFQTAESENRSYEGTLYKKGAFMKPWKARWFVLDKTKHQLRYYDHRVDTECKGVIDLAEVEAVAPGTPTMGAPKTVDEKAFF

--------------------------------------------------------------
>102593_102593_4_ZNF626-SBF1_ZNF626_chr19_20844249_ENST00000601440_SBF1_chr22_50887079_ENST00000348911_length(transcript)=1125nt_BP=150nt
TTCCGGGTTTGGTGCGGCCTTTGTCTCTCGCTGCAGTCAGAGCTCCAGGTCTGGTTCTTCTCCTAAAGGCCCAGGCTGTGTGGCCCCGTG
TCCTGCAGGTATTGGGAGATCCACAGCTAAGACACCGGGACCTCCTGGAAGCCAAAAATGGAGCTGCAGAGGCTGGAGACAGAGTTGGGC
CAACCCGCTGAGCGCTGGAAGGACACCTGGGACCGGGTGAAGGCTGCACAGCGCCTCGAGGGCCGGCCAGACGGCCGTGGCACCCCTAGC
TCCCTCCTTGTGTCCACCGCACCCCACCACCGTCGCTCGCTGGGTGTGTACCTGCAGGAGGGGCCCGTGGGCTCCACCCTGAGCCTCAGC
CTGGACAGCGACCAGAGTAGTGGCTCAACCACATCCGGCTCCCGTCAGGCTGCCCGCCGCAGCACCAGCACCCTGTACAGCCAGTTCCAG
ACAGCAGAGAGTGAGAACAGGTCCTACGAGGGCACTCTGTACAAGAAGGGGGCCTTCATGAAGCCTTGGAAGGCCCGCTGGTTCGTGCTG
GACAAGACCAAGCACCAGCTGCGCTACTACGACCACCGTGTGGACACAGAGTGCAAGGGTGTCATCGACTTGGCGGAGGTGGAGGCTGTG
GCACCTGGCACGCCCACTATGGGTGCCCCTAAGACTGTGGACGAGAAGGCCTTCTTTGACGTGAAGACAACGCGTCGCGTTTACAACTTC
TGTGCCCAGGACGTGCCCTCGGCCCAGCAGTGGGTGGACCGGATCCAGAGCTGCCTGTCGGACGCCTGAGCCTCCCAGCCCTGCCCGGCT
GCTCTGCTTCCGGTCGTTACCGACCACTAGGGGTGGGCAGGGCCGCCCCGGCCATGTTTACAGCCCCGGCCCTCGACAGTATTGAGGCCC
CGAGCCCCCAGCACTTGTGTGTACAGCCCCCGTCCCCGCCCCGCCCCGCCCGGCCGGCCCTAACTTATTTTGGCGTCACAGCTGAGCACC
GTGCCGGGAGGTGGCCAAGGTACAGCCCGCAATGGGCCTGTAAATAGTCCGGCCCCGTCAGCGTGTGCTGGTCCAGCCAGCGGCTGCAGG

>102593_102593_4_ZNF626-SBF1_ZNF626_chr19_20844249_ENST00000601440_SBF1_chr22_50887079_ENST00000348911_length(amino acids)=213AA_BP=1
MELQRLETELGQPAERWKDTWDRVKAAQRLEGRPDGRGTPSSLLVSTAPHHRRSLGVYLQEGPVGSTLSLSLDSDQSSGSTTSGSRQAAR
RSTSTLYSQFQTAESENRSYEGTLYKKGAFMKPWKARWFVLDKTKHQLRYYDHRVDTECKGVIDLAEVEAVAPGTPTMGAPKTVDEKAFF

--------------------------------------------------------------
>102593_102593_5_ZNF626-SBF1_ZNF626_chr19_20844249_ENST00000601440_SBF1_chr22_50887079_ENST00000380817_length(transcript)=2931nt_BP=150nt
TTCCGGGTTTGGTGCGGCCTTTGTCTCTCGCTGCAGTCAGAGCTCCAGGTCTGGTTCTTCTCCTAAAGGCCCAGGCTGTGTGGCCCCGTG
TCCTGCAGGTATTGGGAGATCCACAGCTAAGACACCGGGACCTCCTGGAAGCCAAAAATGGAGCTGCAGAGGCTGGAGACAGAGTTGGGC
CAACCCGCTGAGCGCTGGAAGGACACCTGGGACCGGGTGAAGGCTGCACAGCGCCTCGAGGGCCGGCCAGACGGCCGTGGCACCCCTAGC
TCCCTCCTTGTGTCCACCGCACCCCACCACCGTCGCTCGCTGGGTGTGTACCTGCAGGAGGGGCCCGTGGGCTCCACCCTGAGCCTCAGC
CTGGACAGCGACCAGAGTAGTGGCTCAACCACATCCGGCTCCCGTCAGGCTGCCCGCCGCAGCACCAGCACCCTGTACAGCCAGTTCCAG
ACAGCAGAGAGTGAGAACAGGTCCTACGAGGGCACTCTGTACAAGAAGGGGGCCTTCATGAAGCCTTGGAAGGCCCGCTGGTTCGTGCTG
GACAAGACCAAGCACCAGCTGCGCTACTACGACCACCGTGTGGACACAGAGTGCAAGGGTGTCATCGACTTGGCGGAGGTGGAGGCTGTG
GCACCTGGCACGCCCACTATGGGTGCCCCTAAGACTGTGGACGAGAAGGCCTTCTTTGACGTGAAGACAACGCGTCGCGTTTACAACTTC
TGTGCCCAGGACGTGCCCTCGGCCCAGCAGTGGGTGGACCGGATCCAGAGCTGCCTGTCGGACGCCTGAGCCTCCCAGCCCTGCCCGGCT
GCTCTGCTTCCGGTCGTTACCGACCACTAGGGGTGGGCAGGGCCGCCCCGGCCATGTTTACAGCCCCGGCCCTCGACAGTATTGAGGCCC
CGAGCCCCCAGCACTTGTGTGTACAGCCCCCGTCCCCGCCCCGCCCCGCCCGGCCGGCCCTAACTTATTTTGGCGTCACAGCTGAGCACC
GTGCCGGGAGGTGGCCAAGGTACAGCCCGCAATGGGCCTGTAAATAGTCCGGCCCCGTCAGCGTGTGCTGGTCCAGCCAGCGGCTGCAGG
CGAGTTTCTAGAACCAGAGTCTATATAAAGAGAGAACTAACGCCACGCTCCTGTGCCTGCCTTCCCCACTCCCCGGCTGCCTGCTCTCGG
CCTACCCAGAGGGTCCCATCTGCCCCTATCCAGGCCCACCTGGCGGGAGGTTGGCATCTTTCTCGTGAGCCTCTCCTGGTGCCTGGGTCC
ACCCAGCTCGGCCTGCATGTCCCTGGGAGTGACTTTGCTCTGGGGGCGGATCGAGCAGGAGGCTTCACTGGGGACTTGCTTGATTCCCTC
CACGCCTCAGGGCTGGTCTAGGGGCCGGCACGGCTGGAGAGGAAGCCCCCATCCCTACCCAGGGGATGCAGAAGCTGACCTCACAGAGGC
TTGGGGGTGAAAGGGTGGGTGGTCATTTGACCCCAGAAGGCTGTTGCAGGTCCAGAGGACACTTGAGGTGGACGTCAGTTTCTGGCTAGA
CCCGAGCTGAAGGGATGGAGGCCGGAGGCGGGGGGGGGGGGGGGACAGTGGGCTCCCAGGGGAATGCAGGTTGACCACATCTGGCTCCTG
CCAGGCAACGAGCAGCATCTGGCAGAGTAAGGGGCCAACGCCCATGGGGGATGGACCCTCTCAGTTCTTGGGAATTCTGCCCCAAAAGTC
CTTTCCCTGGGGTCTCAGAGGGCCCCCGTCCTTCCCTTCTTGGTGTCACTGTGGCCCCTCACTGCTCTTTTCCTATTCAAACCTGAGTCC
CACCAGGCCCAGGGCTTCACCTGCTGAGCTGTTGTGTCCTTGCCTGTGACGAGGCCTGGCCAGGGGTGCAGGAGCAGAAGGTGGGGAGGG
TTATAGACGCTGCAAAGGCCAAGAGAACATCTGAGAGTGGCAGCTGGTGACCTGGCCAGAGGGGCTGGTGAGGGGCAGAGAACCTGGCTA
GAGGCTGGGTCCCTCAGGTGGTCCTCTCAGGTGGGAGGCGAGCAGCAGGTGTGGGTGAGGGGAAGGTTCTGATGACAGCTGCAGAGGCAG
GGCCCAGTGCTGGCAGGTGGGGGGCCAAGACCCTCCCCTGGTGGGACGTTGAAGCCAAGGATGGCCTTGGACCCTGTCAGGCCCAGCATG
GTCCCGCCACCTCCCCCACCCCACAGGTGGTGTTGGGACACCTGGGCGAGATGTGAGGGTGGGCTCACTTGAGCCACTGAAACCAGCCAG
GTCTTCCCTCAGGCCGGACAGATGGCGCCTGACCGAAGTTCCTGGCACCTGGAAAACCCACAGGTCAGAGTAAGGGGAGAAAGGACCCTG
CCCTCCCTGTTCCACGTCTGTGGGGGGAGAGGACAAATGCCAGGCACAGGGTAGGCGGCGAGAACAAGGCACTCAATGTGTAGCTGGGGC
AGAGACTCGGCCTCTGGGGAGCTGAGCGGGTTCCCTCCACCCCCAACCGTGGTGGAAAGACAAGCTCGCTGGGGCGGGGTGGGGGTCTGG
TCTCCACCTGCCCCTCCCACTCAGCCACTGAGGACAAGGTGGGGCCCAGGCTTCTGGGAGGGGGAGCTGGCACAAAAGGAAGTCCTGGGG
TTGATGTGTTTGAGCGTTAGGCGAAGTGGTTCCCCCCATCCCCCAAACGGAAAAATGTCAGTATTTGCTAAGCTGTAGAGACCTGATGCC
GTGATGTGGCCTGTTCCGCCTCCACCCATTACACGGGGATAACGCTGGGGGGTGGCGGGCCCACAAAAGAGGTGCTGGAGGAGACTCTCC
CACCCCTGGCCGGGCCGGGGCTTTGGGGCCGGAAGGTTCACAGTACGCGGTTTGTCCGAACGTCACGGCTTTTATTGGGAGTTGGGGGTT

>102593_102593_5_ZNF626-SBF1_ZNF626_chr19_20844249_ENST00000601440_SBF1_chr22_50887079_ENST00000380817_length(amino acids)=213AA_BP=1
MELQRLETELGQPAERWKDTWDRVKAAQRLEGRPDGRGTPSSLLVSTAPHHRRSLGVYLQEGPVGSTLSLSLDSDQSSGSTTSGSRQAAR
RSTSTLYSQFQTAESENRSYEGTLYKKGAFMKPWKARWFVLDKTKHQLRYYDHRVDTECKGVIDLAEVEAVAPGTPTMGAPKTVDEKAFF

--------------------------------------------------------------
>102593_102593_6_ZNF626-SBF1_ZNF626_chr19_20844249_ENST00000601440_SBF1_chr22_50887079_ENST00000390679_length(transcript)=789nt_BP=150nt
TTCCGGGTTTGGTGCGGCCTTTGTCTCTCGCTGCAGTCAGAGCTCCAGGTCTGGTTCTTCTCCTAAAGGCCCAGGCTGTGTGGCCCCGTG
TCCTGCAGGTATTGGGAGATCCACAGCTAAGACACCGGGACCTCCTGGAAGCCAAAAATGGAGCTGCAGAGGCTGGAGACAGAGTTGGGC
CAACCCGCTGAGCGCTGGAAGGACACCTGGGACCGGGTGAAGGCTGCACAGCGCCTCGAGGGCCGGCCAGACGGCCGTGGCACCCCTAGC
TCCCTCCTTGTGTCCACCGCACCCCACCACCGTCGCTCGCTGGGTGTGTACCTGCAGGAGGGGCCCGTGGGCTCCACCCTGAGCCTCAGC
CTGGACAGCGACCAGAGTAGTGGCTCAACCACATCCGGCTCCCGTCAGGCTGCCCGCCGCAGCACCAGCACCCTGTACAGCCAGTTCCAG
ACAGCAGAGAGTGAGAACAGGTCCTACGAGGGCACTCTGTACAAGAAGGGGGCCTTCATGAAGCCTTGGAAGGCCCGCTGGTTCGTGCTG
GACAAGACCAAGCACCAGCTGCGCTACTACGACCACCGTGTGGACACAGAGTGCAAGGGTGTCATCGACTTGGCGGAGGTGGAGGCTGTG
GCACCTGGCACGCCCACTATGGGTGCCCCTAAGACTGTGGACGAGAAGGCCTTCTTTGACGTGAAGACAACGCGTCGCGTTTACAACTTC

>102593_102593_6_ZNF626-SBF1_ZNF626_chr19_20844249_ENST00000601440_SBF1_chr22_50887079_ENST00000390679_length(amino acids)=213AA_BP=1
MELQRLETELGQPAERWKDTWDRVKAAQRLEGRPDGRGTPSSLLVSTAPHHRRSLGVYLQEGPVGSTLSLSLDSDQSSGSTTSGSRQAAR
RSTSTLYSQFQTAESENRSYEGTLYKKGAFMKPWKARWFVLDKTKHQLRYYDHRVDTECKGVIDLAEVEAVAPGTPTMGAPKTVDEKAFF

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ZNF626-SBF1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ZNF626-SBF1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ZNF626-SBF1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source