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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ZNF665-RANBP3L (FusionGDB2 ID:102674)

Fusion Gene Summary for ZNF665-RANBP3L

Fusion gene summary

Fusion gene information	Fusion gene name: ZNF665-RANBP3L
	Fusion gene ID: 102674
		Hgene	Tgene
	Gene symbol	ZNF665	RANBP3L
	Gene ID	79788	202151
	Gene name	zinc finger protein 665	RAN binding protein 3 like
	Synonyms	ZFP160L	-
	Cytomap	19q13.42	5p13.2
	Type of gene	protein-coding	protein-coding
	Description	zinc finger protein 665	ran-binding protein 3-like
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000396424, ENST00000598440, ENST00000600412,	ENST00000296604, ENST00000502994, ENST00000515759,
Fusion gene scores	* DoF score	5 X 5 X 3=75	3 X 1 X 2=6
	# samples	5	3
	** MAII score	log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/6*10)=2.32192809488736
Context	PubMed: ZNF665 [Title/Abstract] AND RANBP3L [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ZNF665(53678698)-RANBP3L(36271413), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across ZNF665 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RANBP3L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-FX-A2QS-01A	ZNF665	chr19	53678698	-	RANBP3L	chr5	36271413	-

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Fusion Gene ORF analysis for ZNF665-RANBP3L

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000396424	ENST00000296604	ZNF665	chr19	53678698	-	RANBP3L	chr5	36271413	-
In-frame	ENST00000396424	ENST00000502994	ZNF665	chr19	53678698	-	RANBP3L	chr5	36271413	-
In-frame	ENST00000396424	ENST00000515759	ZNF665	chr19	53678698	-	RANBP3L	chr5	36271413	-
intron-3CDS	ENST00000598440	ENST00000296604	ZNF665	chr19	53678698	-	RANBP3L	chr5	36271413	-
intron-3CDS	ENST00000598440	ENST00000502994	ZNF665	chr19	53678698	-	RANBP3L	chr5	36271413	-
intron-3CDS	ENST00000598440	ENST00000515759	ZNF665	chr19	53678698	-	RANBP3L	chr5	36271413	-
intron-3CDS	ENST00000600412	ENST00000296604	ZNF665	chr19	53678698	-	RANBP3L	chr5	36271413	-
intron-3CDS	ENST00000600412	ENST00000502994	ZNF665	chr19	53678698	-	RANBP3L	chr5	36271413	-
intron-3CDS	ENST00000600412	ENST00000515759	ZNF665	chr19	53678698	-	RANBP3L	chr5	36271413	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000396424	ZNF665	chr19	53678698	-	ENST00000296604	RANBP3L	chr5	36271413	-	2759	232	90	1538	482
ENST00000396424	ZNF665	chr19	53678698	-	ENST00000502994	RANBP3L	chr5	36271413	-	1935	232	90	1613	507
ENST00000396424	ZNF665	chr19	53678698	-	ENST00000515759	RANBP3L	chr5	36271413	-	1189	232	90	1106	338

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000396424	ENST00000296604	ZNF665	chr19	53678698	-	RANBP3L	chr5	36271413	-	0.000547876	0.9994522
ENST00000396424	ENST00000502994	ZNF665	chr19	53678698	-	RANBP3L	chr5	36271413	-	0.00122312	0.99877685
ENST00000396424	ENST00000515759	ZNF665	chr19	53678698	-	RANBP3L	chr5	36271413	-	0.000723897	0.9992761

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Fusion Genomic Features for ZNF665-RANBP3L

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF665-RANBP3L

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:53678698/chr5:36271413)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

RANBP3L

chr19:53678698

chr5:36271413

ENST00000296604

276_417

466.0

Domain

RanBD1

Tgene

RANBP3L

chr19:53678698

chr5:36271413

ENST00000502994

276_417

491.0

Domain

RanBD1

Tgene

RANBP3L

chr19:53678698

chr5:36271413

ENST00000515759

276_417

322.0

Domain

RanBD1

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ZNF665

chr19:53678698

chr5:36271413

ENST00000396424

8_83

679.0

Domain

KRAB

Hgene

ZNF665

chr19:53678698

chr5:36271413

ENST00000600412

8_83

614.0

Domain

KRAB

Hgene

ZNF665

chr19:53678698

chr5:36271413

ENST00000396424

178_200

679.0

Zinc finger

C2H2-type 1

Hgene

ZNF665

chr19:53678698

chr5:36271413

ENST00000396424

206_228

679.0

Zinc finger

C2H2-type 2

Hgene

ZNF665

chr19:53678698

chr5:36271413

ENST00000396424

234_256

679.0

Zinc finger

C2H2-type 3

Hgene

ZNF665

chr19:53678698

chr5:36271413

ENST00000396424

262_284

679.0

Zinc finger

C2H2-type 4

Hgene

ZNF665

chr19:53678698

chr5:36271413

ENST00000396424

290_312

679.0

Zinc finger

C2H2-type 5

Hgene

ZNF665

chr19:53678698

chr5:36271413

ENST00000396424

318_340

679.0

Zinc finger

C2H2-type 6

Hgene

ZNF665

chr19:53678698

chr5:36271413

ENST00000396424

346_368

679.0

Zinc finger

C2H2-type 7

Hgene

ZNF665

chr19:53678698

chr5:36271413

ENST00000396424

374_396

679.0

Zinc finger

C2H2-type 8

Hgene

ZNF665

chr19:53678698

chr5:36271413

ENST00000396424

402_424

679.0

Zinc finger

C2H2-type 9

Hgene

ZNF665

chr19:53678698

chr5:36271413

ENST00000396424

430_452

679.0

Zinc finger

C2H2-type 10

Hgene

ZNF665

chr19:53678698

chr5:36271413

ENST00000396424

458_480

679.0

Zinc finger

C2H2-type 11

Hgene

ZNF665

chr19:53678698

chr5:36271413

ENST00000396424

486_508

679.0

Zinc finger

C2H2-type 12

Hgene

ZNF665

chr19:53678698

chr5:36271413

ENST00000396424

514_536

679.0

Zinc finger

C2H2-type 13

Hgene

ZNF665

chr19:53678698

chr5:36271413

ENST00000396424

542_564

679.0

Zinc finger

C2H2-type 14

Hgene

ZNF665

chr19:53678698

chr5:36271413

ENST00000396424

570_592

679.0

Zinc finger

C2H2-type 15

Hgene

ZNF665

chr19:53678698

chr5:36271413

ENST00000396424

598_620

679.0

Zinc finger

C2H2-type 16

Hgene

ZNF665

chr19:53678698

chr5:36271413

ENST00000396424

626_648

679.0

Zinc finger

C2H2-type 17

Hgene

ZNF665

chr19:53678698

chr5:36271413

ENST00000396424

654_676

679.0

Zinc finger

C2H2-type 18

Hgene

ZNF665

chr19:53678698

chr5:36271413

ENST00000600412

178_200

614.0

Zinc finger

C2H2-type 1

Hgene

ZNF665

chr19:53678698

chr5:36271413

ENST00000600412

206_228

614.0

Zinc finger

C2H2-type 2

Hgene

ZNF665

chr19:53678698

chr5:36271413

ENST00000600412

234_256

614.0

Zinc finger

C2H2-type 3

Hgene

ZNF665

chr19:53678698

chr5:36271413

ENST00000600412

262_284

614.0

Zinc finger

C2H2-type 4

Hgene

ZNF665

chr19:53678698

chr5:36271413

ENST00000600412

290_312

614.0

Zinc finger

C2H2-type 5

Hgene

ZNF665

chr19:53678698

chr5:36271413

ENST00000600412

318_340

614.0

Zinc finger

C2H2-type 6

Hgene

ZNF665

chr19:53678698

chr5:36271413

ENST00000600412

346_368

614.0

Zinc finger

C2H2-type 7

Hgene

ZNF665

chr19:53678698

chr5:36271413

ENST00000600412

374_396

614.0

Zinc finger

C2H2-type 8

Hgene

ZNF665

chr19:53678698

chr5:36271413

ENST00000600412

402_424

614.0

Zinc finger

C2H2-type 9

Hgene

ZNF665

chr19:53678698

chr5:36271413

ENST00000600412

430_452

614.0

Zinc finger

C2H2-type 10

Hgene

ZNF665

chr19:53678698

chr5:36271413

ENST00000600412

458_480

614.0

Zinc finger

C2H2-type 11

Hgene

ZNF665

chr19:53678698

chr5:36271413

ENST00000600412

486_508

614.0

Zinc finger

C2H2-type 12

Hgene

ZNF665

chr19:53678698

chr5:36271413

ENST00000600412

514_536

614.0

Zinc finger

C2H2-type 13

Hgene

ZNF665

chr19:53678698

chr5:36271413

ENST00000600412

542_564

614.0

Zinc finger

C2H2-type 14

Hgene

ZNF665

chr19:53678698

chr5:36271413

ENST00000600412

570_592

614.0

Zinc finger

C2H2-type 15

Hgene

ZNF665

chr19:53678698

chr5:36271413

ENST00000600412

598_620

614.0

Zinc finger

C2H2-type 16

Hgene

ZNF665

chr19:53678698

chr5:36271413

ENST00000600412

626_648

614.0

Zinc finger

C2H2-type 17

Hgene

ZNF665

chr19:53678698

chr5:36271413

ENST00000600412

654_676

614.0

Zinc finger

C2H2-type 18

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Fusion Gene Sequence for ZNF665-RANBP3L

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>102674_102674_1_ZNF665-RANBP3L_ZNF665_chr19_53678698_ENST00000396424_RANBP3L_chr5_36271413_ENST00000296604_length(transcript)=2759nt_BP=232nt
AAACCCGGAAGCAGATCTCTTGGAGTGAAGGCTGTTAGTCGCCGCGTAGAACCCTGGAAGAAGAGGAAGAGGAAGGCAAAGGAGTCAGGG
ATGGCTCTTCCTCAGGGACAGTTGACATTCAAGGATGTGGCCATAGAATTCTCTCAGGAGGAGTGGACATGCCTGGACCCTGCTCAGAAG
ACTTTGTACAGGGACGTCATGTTGGAGAATTATAGGAACCTGGTCTCCCTGGAAAAATCTGTCATTGCTCAACCCATATTTGTTTTTGAA
AAGGGAGAACAAACTTTTAAGAGACCTGCAGAAGACACCCTGTATGAAGCAGCAGAACCAGAATGTAATGGTTTTCCAACAAAGCGTGTA
CGGTCTTCATCTTTTACTTTTCATATTACAGATTCTCAGTCCCAGGGAGTGAGGAAAAACAATGTTTTTATGACATCAGCTCTTGTGCAA
AGTAGTGTTGATATAAAGAGTGCTGAACAAGGTCCTGTGAAACATTCTAAACATGTTATTAGACCTGCTATTTTGCAGCTACCTCAAGCT
CGAAGTTGTGCAAAAGTAAGAAAAACATTTGGACACAAGGCACTGGAATCTTGCAAGACTAAAGAAAAAACAAATAATAAGATTTCTGAG
GGAAATTCCTATTTGTTAAGTGAAAATTTATCAAGGGCTAGAATTTCAGTCCAGCTGTCTACTAACCAGGACTTTTTAGGTGCAACATCA
GTAGGATGTCAACCAAATGAAGATAAATGTTCTTTTAAAAGCTGCAGTTCCAATTTTGTTTTTGGAGAAAACATGGTAGAAAGAGTTTTG
GGTACTCAAAAACTCACCCAGCCTCAACTTGAAAATGATTCATATGCCAAGGAAAAACCATTCAAATCCATTCCGAAATTTCCTGTCAAC
TTTTTAAGTTCAAGAACAGACTCTATTAAAAATACTTCCCTAATTGAATCAGCTGCTGCATTCTCTTCCCAACCATCACGAAAATGCTTG
CTGGAGAAAATTGATGTTATAACAGGGGAGGAAACAGAACATAATGTGTTAAAGATAAACTGCAAGCTTTTCATATTCAACAAAACAACA
CAATCCTGGATTGAAAGGGGCAGAGGAACGTTGAGACTGAATGACACAGCAAGCACTGACTGTGGAACATTACAGTCAAGACTAATTATG
CGCAATCAAGGCAGTCTAAGGCTGATCCTCAACAGCAAACTCTGGGCCCAAATGAAGATTCAAAGAGCAAACCACAAAAATGTACGAATA
ACAGCTACTGATTTAGAAGACTATAGCATCAAAATATTTTTAATTCAGGCCAGTGCCCAAGATACAGCATATTTGTATGCAGCAATACAT
CATCGTCTTGTTGCACTTCAAAGCTTCAATAAGCAGAGAGATGTCAATCAAGCTGAAAGCCTGTCAGAAACAGCCCAACAATTGAACTGC
GAAAGCTGTGATGAGAATGAGGATGATTTCATCCAAGTCACTAAAAATGGATCAGATCCTTCTAGTTGGACTCACAGACAGTCGGTTGCC
TGTTCATGAATACTACCTACTATAAACATGACATCTACAAAAAGAGGGGTCACCCTACTGAAAATACTAAACCACCCTAACTAATGAGAA
GATTCTATTCATTCCTTGAAGAGTTTTTATAGAAAAGTTTAAGAAATGTAATTTGTTGCAATTAACATTTTTATGTTTTACATTTTACAT
TTTGATTATTGTGCAGAAACTGACAGAATTTAAAAAAATGGACTTCAGAAGTTCAAAATTTATCATTTTTGAAGAAGTTTATTTAGAATA
GGATTTTATAACTAATTTGGACTCTTCATCACATTGATGGATATAATACTTAGAATTATAAATTGCTAGATTTGATAAATACCTAACAAA
ATGTTTATTTTTTTCAGTCATACTTGACCACAAAACAAATATTTTACTAAATTTCCAGAGTCATTTCTCTGAAAAATAGTATAATGGCAT
GATAACATTTCACTAAATCCTATTTATCTTCTGGGAAATATTTTAATTTAGCTTTTGGATTTCCTAATATGATAAGCTTATATATTCATG
GTATGAATTCCTTTAAAAAGAGCATCTGCTCTTGGACTTGTATCTGTTGCATCTTGTCAATGTTTGACTCATGGTCAGCATCCAATAGTT
GTTAAATGAATAAATAAAATATAATACATTACCTATGTATCAAAAAGCATGTGTAAGAAAGCCAAATATGTTAACTGTTCTACTTTATTT
ATGTAATTATATTTTCATTAGTATTTTAGTAGATGGGGCTGTATAGAAAAACAAATGTATCATATGTAGCCAAATGAATCTTTTTCTTAA
ATGATATTATTATAGTAGGCTACAGTAATTTCAACAATTTTACAATAGAGTTTTGATCCTCTTCTTTGCGATTTGTTTCAGAGACACCTC
ATGAATCACACAAGAAAATTAGTCTCAGTACTTATAGCCCTATTTCATTTTTCAATTCAGTTTTATCACACCATGGCTTCGAAGTGACTT
TGATTGTGACCCCTAAGCAATTATCTGATTAGGGGATAAAAATTCATAATTCCAAGATGTTTCTGAAAATGTTCTGAACAATGACAACAT
ATTTGGAATGAGGGCGTAATTTCACTAAGTGATGCTTCGAAGAACAATATTCATTTGGATATGCAAACACACATTTTCAAAAGTTATATT

>102674_102674_1_ZNF665-RANBP3L_ZNF665_chr19_53678698_ENST00000396424_RANBP3L_chr5_36271413_ENST00000296604_length(amino acids)=482AA_BP=47
MALPQGQLTFKDVAIEFSQEEWTCLDPAQKTLYRDVMLENYRNLVSLEKSVIAQPIFVFEKGEQTFKRPAEDTLYEAAEPECNGFPTKRV
RSSSFTFHITDSQSQGVRKNNVFMTSALVQSSVDIKSAEQGPVKHSKHVIRPAILQLPQARSCAKVRKTFGHKALESCKTKEKTNNKISE
GNSYLLSENLSRARISVQLSTNQDFLGATSVGCQPNEDKCSFKSCSSNFVFGENMVERVLGTQKLTQPQLENDSYAKEKPFKSIPKFPVN
FLSSRTDSIKNTSLIESAAAFSSQPSRKCLLEKIDVITGEETEHNVLKINCKLFIFNKTTQSWIERGRGTLRLNDTASTDCGTLQSRLIM
RNQGSLRLILNSKLWAQMKIQRANHKNVRITATDLEDYSIKIFLIQASAQDTAYLYAAIHHRLVALQSFNKQRDVNQAESLSETAQQLNC

--------------------------------------------------------------
>102674_102674_2_ZNF665-RANBP3L_ZNF665_chr19_53678698_ENST00000396424_RANBP3L_chr5_36271413_ENST00000502994_length(transcript)=1935nt_BP=232nt
AAACCCGGAAGCAGATCTCTTGGAGTGAAGGCTGTTAGTCGCCGCGTAGAACCCTGGAAGAAGAGGAAGAGGAAGGCAAAGGAGTCAGGG
ATGGCTCTTCCTCAGGGACAGTTGACATTCAAGGATGTGGCCATAGAATTCTCTCAGGAGGAGTGGACATGCCTGGACCCTGCTCAGAAG
ACTTTGTACAGGGACGTCATGTTGGAGAATTATAGGAACCTGGTCTCCCTGGAAAAATCTGTCATTGCTCAACCCATATTTGTTTTTGAA
AAGGGAGAACAAACTTTTAAGAGACCTGCAGAAGACACCCTGTATGAAGCAGCAGAACCAGAATGTAATGGTTTTCCAACAAAGCGTGTA
CGGTCTTCATCTTTTACTTTTCATATTACAGATTCTCAGTCCCAGGGAGTGTCAACCTTGTCTCAGAAGCAAATGAGATGTTCATCCGTC
ACTAACCTCCCAACCTTCCCCCATTCTGGGCCAGTGAGGAAAAACAATGTTTTTATGACATCAGCTCTTGTGCAAAGTAGTGTTGATATA
AAGAGTGCTGAACAAGGTCCTGTGAAACATTCTAAACATGTTATTAGACCTGCTATTTTGCAGCTACCTCAAGCTCGAAGTTGTGCAAAA
GTAAGAAAAACATTTGGACACAAGGCACTGGAATCTTGCAAGACTAAAGAAAAAACAAATAATAAGATTTCTGAGGGAAATTCCTATTTG
TTAAGTGAAAATTTATCAAGGGCTAGAATTTCAGTCCAGCTGTCTACTAACCAGGACTTTTTAGGTGCAACATCAGTAGGATGTCAACCA
AATGAAGATAAATGTTCTTTTAAAAGCTGCAGTTCCAATTTTGTTTTTGGAGAAAACATGGTAGAAAGAGTTTTGGGTACTCAAAAACTC
ACCCAGCCTCAACTTGAAAATGATTCATATGCCAAGGAAAAACCATTCAAATCCATTCCGAAATTTCCTGTCAACTTTTTAAGTTCAAGA
ACAGACTCTATTAAAAATACTTCCCTAATTGAATCAGCTGCTGCATTCTCTTCCCAACCATCACGAAAATGCTTGCTGGAGAAAATTGAT
GTTATAACAGGGGAGGAAACAGAACATAATGTGTTAAAGATAAACTGCAAGCTTTTCATATTCAACAAAACAACACAATCCTGGATTGAA
AGGGGCAGAGGAACGTTGAGACTGAATGACACAGCAAGCACTGACTGTGGAACATTACAGTCAAGACTAATTATGCGCAATCAAGGCAGT
CTAAGGCTGATCCTCAACAGCAAACTCTGGGCCCAAATGAAGATTCAAAGAGCAAACCACAAAAATGTACGAATAACAGCTACTGATTTA
GAAGACTATAGCATCAAAATATTTTTAATTCAGGCCAGTGCCCAAGATACAGCATATTTGTATGCAGCAATACATCATCGTCTTGTTGCA
CTTCAAAGCTTCAATAAGCAGAGAGATGTCAATCAAGCTGAAAGCCTGTCAGAAACAGCCCAACAATTGAACTGCGAAAGCTGTGATGAG
AATGAGGATGATTTCATCCAAGTCACTAAAAATGGATCAGATCCTTCTAGTTGGACTCACAGACAGTCGGTTGCCTGTTCATGAATACTA
CCTACTATAAACATGACATCTACAAAAAGAGGGGTCACCCTACTGAAAATACTAAACCACCCTAACTAATGAGAAGATTCTATTCATTCC
TTGAAGAGTTTTTATAGAAAAGTTTAAGAAATGTAATTTGTTGCAATTAACATTTTTATGTTTTACATTTTACATTTTGATTATTGTGCA
GAAACTGACAGAATTTAAAAAAATGGACTTCAGAAGTTCAAAATTTATCATTTTTGAAGAAGTTTATTTAGAATAGGATTTTATAACTAA

>102674_102674_2_ZNF665-RANBP3L_ZNF665_chr19_53678698_ENST00000396424_RANBP3L_chr5_36271413_ENST00000502994_length(amino acids)=507AA_BP=47
MALPQGQLTFKDVAIEFSQEEWTCLDPAQKTLYRDVMLENYRNLVSLEKSVIAQPIFVFEKGEQTFKRPAEDTLYEAAEPECNGFPTKRV
RSSSFTFHITDSQSQGVSTLSQKQMRCSSVTNLPTFPHSGPVRKNNVFMTSALVQSSVDIKSAEQGPVKHSKHVIRPAILQLPQARSCAK
VRKTFGHKALESCKTKEKTNNKISEGNSYLLSENLSRARISVQLSTNQDFLGATSVGCQPNEDKCSFKSCSSNFVFGENMVERVLGTQKL
TQPQLENDSYAKEKPFKSIPKFPVNFLSSRTDSIKNTSLIESAAAFSSQPSRKCLLEKIDVITGEETEHNVLKINCKLFIFNKTTQSWIE
RGRGTLRLNDTASTDCGTLQSRLIMRNQGSLRLILNSKLWAQMKIQRANHKNVRITATDLEDYSIKIFLIQASAQDTAYLYAAIHHRLVA

--------------------------------------------------------------
>102674_102674_3_ZNF665-RANBP3L_ZNF665_chr19_53678698_ENST00000396424_RANBP3L_chr5_36271413_ENST00000515759_length(transcript)=1189nt_BP=232nt
AAACCCGGAAGCAGATCTCTTGGAGTGAAGGCTGTTAGTCGCCGCGTAGAACCCTGGAAGAAGAGGAAGAGGAAGGCAAAGGAGTCAGGG
ATGGCTCTTCCTCAGGGACAGTTGACATTCAAGGATGTGGCCATAGAATTCTCTCAGGAGGAGTGGACATGCCTGGACCCTGCTCAGAAG
ACTTTGTACAGGGACGTCATGTTGGAGAATTATAGGAACCTGGTCTCCCTGGAAAAATCTGTCATTGCTCAACCCATATTTGTTTTTGAA
AAGGGAGAACAAACTTTTAAGAGACCTGCAGAAGACACCCTGTATGAAGCAGCAGAACCAGAATGTAATGGTTTTCCAACAAAGCGTGTA
CGGTCTTCATCTTTTACTTTTCATATTACAGATTCTCAGTCCCAGGGAGTGAGGAAAAACAATGTTTTTATGACATCAGCTCTTGTGCAA
AGTAGTGTTGATATAAAGAGTGCTGAACAAGGTCCTGTGAAACATTCTAAACATGTTATTAGACCTGCTATTTTGCAGCTACCTCAAGCT
CGAAGTTGTGCAAAAGTAAGAAAAACATTTGGACACAAGGCACTGGAATCTTGCAAGACTAAAGAAAAAACAAATAATAAGATTTCTGAG
GGAAATTCCTATTTGTTAAGTGAAAATTTATCAAGGGCTAGAATTTCAGTCCAGCTGTCTACTAACCAGGACTTTTTAGGTGCAACATCA
GTAGGATGTCAACCAAATGAAGATAAATGTTCTTTTAAAAGCTGCAGTTCCAATTTTGTTTTTGGAGAAAACATGGTAGAAAGAGTTTTG
GGTACTCAAAAACTCACCCAGCCTCAACTTGAAAATGATTCATATGCCAAGGAAAAACCATTCAAATCCATTCCGAAATTTCCTGTCAAC
TTTTTAAGTTCAAGAACAGACTCTATTAAAAATACTTCCCTAATTGAATCAGCTGCTGCATTCTCTTCCCAACCATCACGAAAATGCTTG
CTGGAGAAAATTGATGTTATAACAGGGGAGGAAACAGAACATAATGTGTTAAAGGTCTGTATATCATGTTTTACTCTTTCTGGTAGCATT
TACATACTTGGAATAAAGTTAACATGAGAAGAGGCATCTTTAAAAATACAGACAGAAGTATAGTTTTCATGGAGACTAAGTTGCTTAAAT

>102674_102674_3_ZNF665-RANBP3L_ZNF665_chr19_53678698_ENST00000396424_RANBP3L_chr5_36271413_ENST00000515759_length(amino acids)=338AA_BP=47
MALPQGQLTFKDVAIEFSQEEWTCLDPAQKTLYRDVMLENYRNLVSLEKSVIAQPIFVFEKGEQTFKRPAEDTLYEAAEPECNGFPTKRV
RSSSFTFHITDSQSQGVRKNNVFMTSALVQSSVDIKSAEQGPVKHSKHVIRPAILQLPQARSCAKVRKTFGHKALESCKTKEKTNNKISE
GNSYLLSENLSRARISVQLSTNQDFLGATSVGCQPNEDKCSFKSCSSNFVFGENMVERVLGTQKLTQPQLENDSYAKEKPFKSIPKFPVN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZNF665-RANBP3L

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ZNF665-RANBP3L

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ZNF665-RANBP3L

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source