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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF66-MLLT3 (FusionGDB2 ID:102680)

Fusion Gene Summary for ZNF66-MLLT3

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF66-MLLT3
Fusion gene ID: 102680
HgeneTgene
Gene symbol

ZNF66

MLLT3

Gene ID

7617

4300

Gene namezinc finger protein 66MLLT3 super elongation complex subunit
SynonymsZNF66PAF9|YEATS3
Cytomap

19p12

9p21.3

Type of geneprotein-codingprotein-coding
Descriptionputative zinc finger protein 66protein AF-9ALL1-fused gene from chromosome 9 proteinKMT2A/MLLT3 fusionKMT2A/MLLT3 fusion proteinYEATS domain-containing protein 3myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 3myeloid/lymphoid or mixed-lineage leu
Modification date2020031320200327
UniProtAcc.

P42568

Ensembl transtripts involved in fusion geneENST00000344519, ENST00000360204, 
ENST00000425625, ENST00000594534, 
ENST00000355930, ENST00000429426, 
ENST00000380321, ENST00000475957, 
ENST00000380338, 
Fusion gene scores* DoF score1 X 1 X 1=118 X 37 X 9=5994
# samples 135
** MAII scorelog2(1/1*10)=3.32192809488736log2(35/5994*10)=-4.09809225668125
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF66 [Title/Abstract] AND MLLT3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF66(20976684)-MLLT3(20448264), # samples:1
Anticipated loss of major functional domain due to fusion event.ZNF66-MLLT3 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ZNF66-MLLT3 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMLLT3

GO:0045893

positive regulation of transcription, DNA-templated

25417107|27105114

TgeneMLLT3

GO:0090090

negative regulation of canonical Wnt signaling pathway

19591803


check buttonFusion gene breakpoints across ZNF66 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MLLT3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-69-7980-01AZNF66chr19

20976684

+MLLT3chr9

20448264

-


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Fusion Gene ORF analysis for ZNF66-MLLT3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000344519ENST00000355930ZNF66chr19

20976684

+MLLT3chr9

20448264

-
5CDS-5UTRENST00000344519ENST00000429426ZNF66chr19

20976684

+MLLT3chr9

20448264

-
5CDS-5UTRENST00000360204ENST00000355930ZNF66chr19

20976684

+MLLT3chr9

20448264

-
5CDS-5UTRENST00000360204ENST00000429426ZNF66chr19

20976684

+MLLT3chr9

20448264

-
5CDS-5UTRENST00000425625ENST00000355930ZNF66chr19

20976684

+MLLT3chr9

20448264

-
5CDS-5UTRENST00000425625ENST00000429426ZNF66chr19

20976684

+MLLT3chr9

20448264

-
5CDS-5UTRENST00000594534ENST00000355930ZNF66chr19

20976684

+MLLT3chr9

20448264

-
5CDS-5UTRENST00000594534ENST00000429426ZNF66chr19

20976684

+MLLT3chr9

20448264

-
5CDS-intronENST00000344519ENST00000380321ZNF66chr19

20976684

+MLLT3chr9

20448264

-
5CDS-intronENST00000344519ENST00000475957ZNF66chr19

20976684

+MLLT3chr9

20448264

-
5CDS-intronENST00000360204ENST00000380321ZNF66chr19

20976684

+MLLT3chr9

20448264

-
5CDS-intronENST00000360204ENST00000475957ZNF66chr19

20976684

+MLLT3chr9

20448264

-
5CDS-intronENST00000425625ENST00000380321ZNF66chr19

20976684

+MLLT3chr9

20448264

-
5CDS-intronENST00000425625ENST00000475957ZNF66chr19

20976684

+MLLT3chr9

20448264

-
5CDS-intronENST00000594534ENST00000380321ZNF66chr19

20976684

+MLLT3chr9

20448264

-
5CDS-intronENST00000594534ENST00000475957ZNF66chr19

20976684

+MLLT3chr9

20448264

-
Frame-shiftENST00000344519ENST00000380338ZNF66chr19

20976684

+MLLT3chr9

20448264

-
Frame-shiftENST00000425625ENST00000380338ZNF66chr19

20976684

+MLLT3chr9

20448264

-
Frame-shiftENST00000594534ENST00000380338ZNF66chr19

20976684

+MLLT3chr9

20448264

-
In-frameENST00000360204ENST00000380338ZNF66chr19

20976684

+MLLT3chr9

20448264

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000360204ZNF66chr1920976684+ENST00000380338MLLT3chr920448264-7233102410632454463

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000360204ENST00000380338ZNF66chr1920976684+MLLT3chr920448264-0.0001710840.99982893

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Fusion Genomic Features for ZNF66-MLLT3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF66-MLLT3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:20976684/chr9:20448264)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MLLT3

P42568

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948, PubMed:25417107, PubMed:27105114, PubMed:27545619). Specifically recognizes and binds acylated histone H3, with a preference for histone H3 that is crotonylated (PubMed:25417107, PubMed:27105114, PubMed:27545619, PubMed:30374167, PubMed:30385749). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25417107, PubMed:27105114, PubMed:27545619). Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylated at 'Lys-18' (H3K18cr) (PubMed:27105114). Also recognizes and binds histone H3 acetylated and butyrylated at 'Lys-9' (H3K9ac and H3K9bu, respectively), but with lower affinity than crotonylated histone H3 (PubMed:25417107, PubMed:27105114, PubMed:30385749). In the SEC complex, MLLT3 is required to recruit the complex to crotonylated histones (PubMed:27105114, PubMed:27545619). Recruitment of the SEC complex to crotonylated histones promotes recruitment of DOT1L on active chromatin to deposit histone H3 'Lys-79' methylation (H3K79me) (PubMed:25417107). Plays a key role in hematopoietic stem cell (HSC) maintenance by preserving, rather than confering, HSC stemness (PubMed:31776511). Acts by binding to the transcription start site of active genes in HSCs and sustaining level of H3K79me2, probably by recruiting DOT1L (PubMed:31776511). {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:25417107, ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:27545619, ECO:0000269|PubMed:30374167, ECO:0000269|PubMed:30385749, ECO:0000269|PubMed:31776511}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF66chr19:20976684chr9:20448264ENST00000344519+344_7575574.0DomainKRAB
TgeneMLLT3chr19:20976684chr9:20448264ENST00000380338211149_19492569.0Compositional biasNote=Poly-Ser
TgeneMLLT3chr19:20976684chr9:20448264ENST00000380338211383_39192569.0Compositional biasNote=Poly-Ser
TgeneMLLT3chr19:20976684chr9:20448264ENST00000380338211466_46992569.0Compositional biasNote=Poly-Pro
TgeneMLLT3chr19:20976684chr9:20448264ENST00000380338211295_30092569.0MotifNuclear localization signal
TgeneMLLT3chr19:20976684chr9:20448264ENST00000380338211106_10892569.0RegionHistone H3K9cr binding
TgeneMLLT3chr19:20976684chr9:20448264ENST00000380338211106_10992569.0RegionInhibitor XL-07i binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF66chr19:20976684chr9:20448264ENST00000344519+34145_16775574.0Zinc fingerC2H2-type 1%3B atypical
HgeneZNF66chr19:20976684chr9:20448264ENST00000344519+34171_19575574.0Zinc fingerC2H2-type 2
HgeneZNF66chr19:20976684chr9:20448264ENST00000344519+34201_22375574.0Zinc fingerC2H2-type 3
HgeneZNF66chr19:20976684chr9:20448264ENST00000344519+34229_25175574.0Zinc fingerC2H2-type 4
HgeneZNF66chr19:20976684chr9:20448264ENST00000344519+34257_27975574.0Zinc fingerC2H2-type 5
HgeneZNF66chr19:20976684chr9:20448264ENST00000344519+34285_30775574.0Zinc fingerC2H2-type 6
HgeneZNF66chr19:20976684chr9:20448264ENST00000344519+34313_33575574.0Zinc fingerC2H2-type 7
HgeneZNF66chr19:20976684chr9:20448264ENST00000344519+34341_36375574.0Zinc fingerC2H2-type 8
HgeneZNF66chr19:20976684chr9:20448264ENST00000344519+34369_39175574.0Zinc fingerC2H2-type 9
HgeneZNF66chr19:20976684chr9:20448264ENST00000344519+34397_41975574.0Zinc fingerC2H2-type 10
HgeneZNF66chr19:20976684chr9:20448264ENST00000344519+34425_44775574.0Zinc fingerC2H2-type 11
HgeneZNF66chr19:20976684chr9:20448264ENST00000344519+34453_47575574.0Zinc fingerC2H2-type 12
HgeneZNF66chr19:20976684chr9:20448264ENST00000344519+34481_50375574.0Zinc fingerC2H2-type 13
HgeneZNF66chr19:20976684chr9:20448264ENST00000344519+34509_53175574.0Zinc fingerC2H2-type 14
HgeneZNF66chr19:20976684chr9:20448264ENST00000344519+34537_55975574.0Zinc fingerC2H2-type 15
TgeneMLLT3chr19:20976684chr9:20448264ENST000003803382111_13892569.0DomainYEATS
TgeneMLLT3chr19:20976684chr9:20448264ENST0000038033821156_5892569.0RegionInhibitor XL-07i binding
TgeneMLLT3chr19:20976684chr9:20448264ENST0000038033821178_8092569.0RegionHistone H3K9cr binding


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Fusion Gene Sequence for ZNF66-MLLT3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>102680_102680_1_ZNF66-MLLT3_ZNF66_chr19_20976684_ENST00000360204_MLLT3_chr9_20448264_ENST00000380338_length(transcript)=7233nt_BP=1024nt
GTCTCTCCCTGCAGCTGGAGCTCCAGGTCGTCTGTTCACTGCTCTCTGTCTTCTTCTCCTAGAGGCCCAGCCTCTGTGGCCCTGTGTCCT
GCAGGTATTGGGAGATCCACAGCTAAGACGCCAGGACCCCCTGGAAGCCTAGAAATGGTGAGAGTGCCGGTCCAGCATCCCGAGAGAGGG
GCCATTGCAATTTAGAGATGTGGCCATAGAATTCTCTCTGGAGGAGTGGCATTGCCTGGACATGGCACAGCGGAATTTATATAGGGATGT
GATGTTAGAGAACTACAGAAACCTGGTCTTTCTTGGTAGGTGTGAGTGAAAATGAATACAACAGACAACACAGTAAGAAGTCCAAGGTCA
AAAAGAAAGCCAGTCCTTAAGGTGTGATTCTGGAAGCTGTGTTCCAAAGGAACTTCTGGGCAGCTGTTTTTTTTGTTTTTTGTTTTTGTT
TTTGTTGTTTTAAATTTTGCTGTCACAAAGGGGCATATTGTCTTATGCTTCTAAATTCTCTAAAAATTCTACTTTTCTCTCAGTGAGCTT
CCTTCACATTCACAGTGAGAGCCAAAGTCCTCTTCATGACATATAAGAGACAGCACAATCCAGCTGCTTTTTCATTGTTTTGGGGACACA
CAAATATCTTCCTAATTTTGAGAAACTGAAACTATTTTTTAGTTTTCTTTTTGTATCCGGTCTGAAATTTGTGAGAGTAGTAGTTTCTGT
TGCATTTTTTTTTGTTCATTTTTGTGCACAGTCCATTCTATTTTTATTACTATATAGTCTTGAAATATAGTTTGAAATTGTAAGTACGAT
ATTCTGTTTTCTTCTTTTTCCTCAAGATTGCTTTGGCTATTCAAAGTTTATTTTAGTTTCATGTAAATTTTAGAATTGTATTTTCCATTA
TTGTAAAAAAAAACACTGCAATTTTAATAGGAAGATTATTGAGTCTGTAAATCACTTTGGATAATATGATTCTTTAATAATATTTATTCT
TTTAATTCATTGACATAAAATATTTTAAAATTAAGAAGAACCTAGGAAAGTCCGCTTTGATTATGACTTATTCCTGCATCTTGAAGGCCA
TCCACCAGTGAATCACCTCCGCTGTGAAAAGCTAACTTTCAACAACCCCACAGAGGACTTTAGGAGAAAGTTGCTGAAGGCAGGAGGGGA
CCCTAATAGGAGTATTCATACCAGCAGCAGCAGCAGCAGCAGCAGTAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGTAGCAGCAGCAG
CAGCAGCAGCAGCAGCAGCAGTAGCAGCAGCAGTAGCAGCAGCAGCAGCAGCAGTAGTACCAGTTTTTCAAAGCCTCACAAATTAATGAA
GGAGCACAAGGAAAAACCTTCTAAAGACTCCAGAGAACATAAAAGTGCCTTCAAAGAACCTTCCAGGGATCACAACAAATCTTCCAAAGA
ATCCTCTAAGAAACCCAAAGAAAATAAACCACTGAAAGAAGAGAAAATAGTTCCTAAGATGGCCTTCAAGGAACCTAAACCCATGTCAAA
AGAGCCAAAACCAGATAGTAACTTACTCACCATCACCAGTGGACAAGATAAGAAGGCTCCTAGTAAAAGGCCGCCCATTTCAGATTCTGA
AGAACTCTCAGCCAAAAAAAGGAAAAAGAGTAGCTCAGAGGCTTTATTTAAAAGTTTTTCTAGCGCACCACCACTGATACTCACTTGTTC
TGCTGACAAAAAACAGATAAAAGATAAATCTCATGTCAAGATGGGAAAGGTCAAAATTGAAAGTGAGACATCAGAGAAGAAGAAATCAAC
GTTACCGCCATTTGATGATATTGTGGATCCCAATGATTCAGATGTGGAGGAGAATATATCCTCTAAATCTGATTCTGAACAACCCAGTCC
TGCCAGCTCCAGCTCCAGCTCCAGCTCCAGCTTCACACCATCCCAGACCAGGCAACAAGGTCCTTTGAGGTCTATAATGAAAGATCTGCA
TTCTGATGACAATGAGGAGGAATCAGATGAAGTGGAGGATAACGACAATGACTCTGAAATGGAGAGGCCTGTAAATAGAGGAGGCAGCCG
AAGTCGCAGAGTTAGCTTAAGTGATGGCAGCGATAGTGAAAGCAGTTCTGCTTCTTCACCCCTACATCACGAACCTCCACCACCCTTACT
AAAAACCAACAACAACCAGATTCTTGAAGTGAAAAGTCCAATAAAGCAAAGCAAATCAGATAAGCAAATAAAGAATGGTGAATGTGACAA
GGCATACCTAGATGAACTGGTAGAGCTTCACAGAAGGTTAATGACATTGAGAGAAAGACACATTCTGCAGCAGATCGTGAACCTTATAGA
AGAAACTGGACACTTTCATATCACAAACACAACATTTGATTTTGATCTTTGCTCGCTGGACAAAACCACAGTCCGTAAACTACAGAGTTA
CCTGGAAACATCTGGAACATCCTGAGGATATAACAACTGGATGCATCAAGAACTATTGTGTTTTTTTTTTTTGGTTTTTTTTTTTTTTGG
TTGTGATTTTTTGTTCTTGTTGTTTATATGAAAACACTCAAAATGATGCAACCAAAAGGGAAAAAATAAAAATCAAACAACCTTCAGCTT
TATTTTTCTTTAAAGCCAGTCATCATCTCTTGATAAAGGAGAGGTTAAAGCAAACCAGCCTCAGCGGACCACTCTTCTCTCCAAGGAAAT
CCCCGGGAAGAGTTAGCCTGGATAGCCTTGAAAACAAACAAATCAAACACAACACAAGAAAACTCAAAGAATGTGTATGGTATCATGTAT
CTCTCTGTGGTGGTTCATTCCACAGGACGAATGCATATTCAACACACTGCCTTATTACATAACTGATCTATTTATTATCGCATACAGATA
TTCTAAGTCGTTGAGGGAATGACACCATCAGACATTATAAGTACTTGGTCCCGTGGATGCTCTTTCAATGCAGCACCCTTGCCATCCCAA
GCCCAGTGACCTTACTCGTATACCGTGCCACTTTCCACCAACTTTTTCCAAGTCCTTTAACTCGTTGCAGTCTGTATTTTCCACCTTTTG
TTTTTCCAGTTCCAGGACACAGATTATCAACTGGGGGGACCAAATAGCCACCTTGATTTTCTTCTTTGTGGTCTTTTTCCTGAAAGTTGG
GGCCCAGTCCTTGGCTGTATCCATGTAATGATCTTGGACCATGGTAGAAAATGCACCAAATAGGATCATATGAATTGCTGTCTAGCCTTA
GTCAATAAACTTGTAGGACTTTTAAACAAAAGTGTACCTGTAAATGTCCTGAATCCAGCATTGTTGAGCTGTCATCAACATTCTTGTGTC
TGTTTTACTGTTACAATATTAGGTGAATATGGAAGTAAAGGCATTCCACAGGATCATCATTTAAAAAAAAAGAATTCTGGTCCTGTTTTC
TAAAAAAAAAAACTGTTGTAGAAATTCTTAATTTGGATCTATTTATTAGTCAGAGTTTCAGCTTTCTTCAGCTGCCAGTGTGTTACTCAT
CTTTATCCTAAAAATCTGGAATCAGAGATTTTTGTTTGTTCACATATGATTCTCTTAGACACTTTTATATTTGAAAAAATTAAAATCTTT
CTTTGGGGAAAAATTCTTGGTTATTCTGCCATAACAGATTATGTATTAACTTGTAGATTCAGTGGTTCAATACCTGTTTAGTTGCTTGCT
AATATTTCCAGAAGGATTTCTTGTATTGGTGAAAGACGGTTGGGGATGGGGGGATTTTTTTGTTCTTGTTGTACCCTTGTTTTGAAACTA
GAAATCTGTCCTGTGGCATGCAAAAGAAAGCAAATTATTTTTAAAAGAAAAAAACCAAAGTACTTTTGGTGTCATTATTCCATCTTCTCC
ATAAGTGGAGAAATGAAAAGTAAGAACAGCTCATCTTCAAAGTTTTTACTAGAAATTCAGCCGAAAAGAAGAGAAATGAAGAAATACTTC
TGGATCCAAAGGTTCGTCACTGGATCAGCCTTAAGAAAGTCTCTATGTGTGCTAATAGACCAGTATCTCCCTTGTTTGTTCCCATGCCAG
ATGCTGTCTTTTCATACAGAGATTAACTAGTGTCTGTACAGAAAATGGTCTTTCCAGACCCATTCTTTTGGGCAGTTATATAAATGCAGA
TTGATAATGGAGTTATTTCTGCATTTTAAAAAGGGGATTTTTTACACTGTTTCTTTCTATCCAAAGAAACTATTTTTCCTTTAAAAAATT
ATAATACAGCCATGCTCCTTGTAAATTATTTCTCTGAAGCGTCCTCCCAGAGGACAAGTGTACTTTCTCAATAATGTTATGATTCTTAAT
GACGATTGGCATGAACCGTACTTGAAGCATTTGTTGTATTGTCCACTTCTTGATGTGCAGAGAAACTTTGAGTCATTTTGGACATTAGGT
GATTGATGAATTGTGTGGTTTCAGTTGCGTTTTGTTTTTAACTTTATAGCTGGAAGGGGAGGGTAATGTTTATATGGAAATGTTGCAAAT
TTTTAAAATATTTTAAAATTTCTAACTGCTAACACATATTCTGATCAAGCCAGAAGTTTATGTGATTTAATATATCTGTGTAGTTTAACT
AGAAACGTATATATGTAGTTTGGGCCATTTTTATTTCTGTAACTAAATTGTGGGGCAAAAAATATGATTTGCCAATGTAAAAATTTTTTC
CTTTAAGTTACTAACCAAGAAGCTAGGTAAGATAAGAAATGACCAAACAAAAATAATGATAAGAAGGACAGCTATTATATGATAAACTTT
AGACTTGAAAATTAGGTAATAAAGTTAATTTCTTCAGAATATCCTAAAATGTAAGTTTGTAAATTGATAAAGTTCAGAAAAACTTATCCA
TCTTCTACTCATCAAGATAGCAAAGTAAGTTTTTCACAAAATTAAGACTGAGAGTTACGTTATTTTTTTTGAAGTGGTAATCTTGCTCTC
ATCTAATTTTTAAATACAGAAATAAAAAGATCCCTTTGAATTAATTTCAAGTAGTTTTAATACCTCTCTTAAAGTAACCCCTTCAGTTCT
GTCACATTTATATACACCCAACTTTGAAGCCTATTAAGAATATCTTTGACATGTGAGTACCCTAACAGTGGCTCTGGTTTCTTAAGCACA
AAGGGAAAATGGCAGGGTTTAATTTCTTTGGTGTACATATATAAATAGATGTTTCAAATAAAATTAATTGGGTAAATGTGAATATGGTTT
GAACCAGCCAGAGTATGATAAACTTTTAAAAAATTTTTCCTCAGTGATCAGCCAGGGGAAAAAATATATGTACAGAGCTCCTGCCCCTCT
GCCCCCTTATAACTTAGCTTTTGCCTCTGGTTTTGCAGCAGGATGTGTGTTGGTGGGTTTGGGGTTCCTTCTGTCTTCGGATGTAACAGT
CATGTTAGCAACAATATTTTGCAGTTACTTCACCATCCTCAGCATAATCTGCCTCTCTCTCAATCTTAATACAGACAAATAGGTATGTCT
ATAAATGCGTTCATATAGTGTCAAGGTAGGGAAGACTATAAAAACTTCAGATCAGGAAAAAAATATCTCTTAAGAGAGTGTCTTAAACAT
TTTAAATTGCTAGGCAATTTAAATCTCTCTAATCTGAATATTCACCTTTTGGTGGAAAGAGCCAGTAATATTGGTTTTCTTCCACTAAAA
AGTTTCTTCAAAATTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGCCGATATCTTTTACAGGCCCACCTAATCTTTAAAAAAAAGAGAAG
AAACAATTTTAGGCCTGTATAACATCCTATTTACTACTTCAAGCTCCACAAATGTAGTTAATATATTTGTTTAAGAGAGACTTTACTCTT
AAATGTTTTAACTTTGCCTACTTAATGGAGTTGGATGTCCAGTGTTGGAAACAGTCAGTGTCTGTTTGGTGGCTCGTGTTTATTTTTGTC
ACTGTAGAAGTGATCTGCTCTGGAGTAATTTGCTGTATGCTTATTACTTTCCACCTTTAGCGTTTTGTGTACTAATGCTATGTACTGCTC
CTATATTTATATATACATATATATATATATATACACATATATATTATCAGAGTAATCTTGCTTTGGACTGTTGCTCTAAAACTATGAATA
TGATGTAGAGACTACTACAGCTGCAGTGAATGTTAAGGAGTCAATTCCCATGGTTTAGTTTAGTCTCGGGCTGGAAGTCTACATCTTTTG
ACCTCTTTTGTTTTATATGATGCTTTTTATTATGTAGGCACTGCCATCCCTGAATATTCCTTGTAAAGATGCAGTGAAGAAGTCAATTTA
AAAGGAAGACAAAGCCACCGCTGTCTGTAAACTGTAAATGTGTATTTTGGCACTTGTACTCCAGTATTCTGAAAATAGAGTTATGATGGA
AATGCTGACAGATCCTTAATGGTGGCCAGAGCTACCATGCAGTGCAAAAATAAATTAAGTGAAAATGTATTATTGAGATTAACAGTGCAA
GGCCAATACATTTTATAAATCTGTCAGTATCTTTTTAATGGACTGTGTATGTGTAGTTATGTTGAAAGATACATTGTGTATGTGTACATG
CTTTTGTGTGAATTCAAGGCACACTGTAAGATGTATTTCCCTTCTCTAAAATCCATGTTGAAATGTAAGTACAGATTGATAGAAATAGGT
GTTTTACTTAAACTCATATAATCTGTTTCAGCACCTTTTTTAAAATGTATAATTGTACTGATTTGCTGAGAGTCATTTGACCAAAGTTTG
GCTTTATTTTGCATACAGGAAAAATTAGCCCCTAGCCTTTTCTCAAGAAGTGATGCTGTTTCTAAAGAAGAATAGATGGGGAGATCTGAG
ACATCCAGAGAGAGGACAATGTGTCCAAAACCAGCTGAAGGCAGAGAGTCCATGCCTCATTCATTTTAGGAGTCCCTCATGTCTAACACC
ATCTTCTGTGTCCTAAAGCCAGTATATATATAATATTTTTAAAACTCTGCAAAGATTGGAACAAGAAGTGGTGGGATACATTTTTTGGCA
TAAACTGGGCTATGTGTGCCCGGTATTTTTTCTTTCCCCCCTATTTCTTTGGAGGGTTTTGTTCAGAAACAATGTGCTATAGCCAGAGAG
AGTCGATCTTACAAAGTCCCTGCATTTACTTTCACAGCAAGAACTGCTACCTTGATTAGACAGGAAGGAGAACAACTACTACAACAAAGA

>102680_102680_1_ZNF66-MLLT3_ZNF66_chr19_20976684_ENST00000360204_MLLT3_chr9_20448264_ENST00000380338_length(amino acids)=463AA_BP=
MHLEGHPPVNHLRCEKLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSK
PHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENKPLKEEKIVPKMAFKEPKPMSKEPKPDSNLLTITSGQDKKAPSKRP
PISDSEELSAKKRKKSSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSTLPPFDDIVDPNDSDVEENISSKSD
SEQPSPASSSSSSSSSFTPSQTRQQGPLRSIMKDLHSDDNEEESDEVEDNDNDSEMERPVNRGGSRSRRVSLSDGSDSESSSASSPLHHE
PPPPLLKTNNNQILEVKSPIKQSKSDKQIKNGECDKAYLDELVELHRRLMTLRERHILQQIVNLIEETGHFHITNTTFDFDLCSLDKTTV

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Fusion Gene PPI Analysis for ZNF66-MLLT3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF66-MLLT3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF66-MLLT3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource